Black Cyan Magenta Yellow CUTTER GUIDE DO NOT PRINT

DSM Nutritional Products

RONOZYME® NPThe better phytase

DSM Nutritional Products Ltd PO Box 2676

CH-4002 Basel

Switzerland

www.dsmnutritionalproducts.com

For DSM, quality is a way of life. This is the core of Quality for Life™.

Quality for Life™ is the mark of quality, reliability and traceability. It means that DSM customers are getting the best

nutrition & health ingredients, knowing the source on which they depend.

Quality for Life™ means sustainability. It symbolizes our commitment to our environment, consumer, our business

partners, our people and the regulatory framework that governs our operations.

With the Quality for Life™ seal, we provide peace of mind for you and for your customers.

Unlimited.DSM

TM

52000

© D

SM

Nut

ritiona

l Pro

duc

ts L

td• Produced by Mardle Consulting • D

esigned by mono design • www.monodesign.co.uk • 10/2009

Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the

accuracy, reliability, or completeness of the information. The information provided herein is for informational purposes and is intended for business to business use

only. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, either

expressly or implied. In no event shall DSM be liable for any damages arising from the reader's reliance upon, or use of, these materials. The reader shall be solely

responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contact

your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlands

and/or other countries.

Reducing feed costs withoutcompromising the performanceof animals with high genetic po-tential is a major profit driver inlivestock farming systems. Asglobal market forces increasethe variability of cost of feed in-gredients, so increasing effi-ciency and flexibility becomesthe prime objective.

This is as true for phosphorous as forenergy and protein. Phosphorus is an essential mineral in the nutrition of allclasses of livestock. However most com-mercial diets are based on cereals andoilseeds in which the bioavailability ofphosphorus is poor.

The reason the naturally occurring phos -phorus is unavailable to animals is that itis present as phytate phosphorus whichis a largely indigestible molecule. It is indigestible because the digestivetracts of monogastric species do nothave adequate concentrations of the phytase enzymes capable of releasing the phosphorus.

To ensure adequate available phospho-rus, it has been traditional and cost effec-tive to add sources of inorganicphosphorus. This has two consequences.The first is that its highly volatile price in-creases feed costs. The second is that allthe unavailable phosphorus is excretedleading to increased environmental pollu-tion with phosphates.

Feeding supplementary microbial phy -tases can increase the digestibility andutilization of phosphorus in cereals andoilseeds, therefore reducing feed costsand environmental pollution.

RONOZYME® NP is a new phytase offering from DSM Nutritional Productsand Novozymes which is proven to deliver outstanding results in a rangeof monogastric production systems.

Introduction

2

3

What is RONOZYME®

NP?

RONOZYME® NP - The better phytase

RONOZYME® NP...

...better phytase efficacy...

...better heat stability...

...better cost efficacy...

...for higher profits

RONOZYME® NP is the latest phytaseoffering of the RONOZYME® feedenzyme portfolio designed to meet thedemands of modern productionsystems. It allows a higher release ofphytate phosphorus, so allows greaterreduction in feed costs through lowerinclusion rates of inorganic phosphate.

Following extensive trials RONOZYME®NPis proven in pig and poultry systems, toimprove phosphorus metabolism andperformance. In addition, other mineralssuch as calcium, magnesium and traceminerals that are bound to the phytic acidare released for absorption. The higherintrinsic heat stability allows to survive inthe digestive tract during feeding. It haseven been shown to deliver higher costeffective results at levels in excess oftraditional inclusion rates, offering thechance to further reduce inorganicphosphate supplementation rates for better cost saving.

RONOZYME® NP combines thisexceptional effectiveness withoutstanding ease of use. The CT form isthe most heat stable, able to withstandthe harsh conditions experienced inanimal feed manufacture.

Available in three different forms, it canbe easily incorporated into any feedmanufacturing system while its flow andmixing characteristics mean finished feed quality is not compromised. It meets industry standards forhomogeneity and safety in premix and feed production.

What does RONOZYME® NP do?

• Increases the availability of phosphorusfrom cereals and oilseeds

• Reduces the need for inorganicphosphate supplementation

• Increases performance in pigs and poultry

• Reduces environmental phosphatepollution

• More effective at higher inclusion ratesthan usual - so maximising increases in phosphate digestion

RONOZYME®

NP – better phytase efficacy

Improvement in phosphorusand calcium digestion in pigs

70

60

50

40

300

P Ca

150g/t 300g/t

Improvement in phosphorusand calcium digestion in layers

90

80

70

60

50

40

300

RONOZYME® NP CT addition g/t60g/t 90g/t 120g/t

50

45

40Control

Tibia ash (%)

Digestibility (%

)Digestibility (%

)

Ronozyme® NPat classic dose

Phytase P

4

Improved phosphorusutilizationAnimals fed RONOZYME® NPuse phosphorus more effectively

Bone mineralisation, usually analyzed byassessing tibia ash content, is recognizedas an effective measure of phosphorusutilization. Trials comparing RONOZYME®

NP to control diets and a competitorproduct show significantly higher bonemineralization, and therefore betterphosphorus utilization.

Results from trials demonstrate the beneficial effect of RONOZYME® NP in pig and poultry units.

DSM France (CRNA), 2006

Germany, 2007

DSM France (CRNA), 2007

Improved phosphorusand calcium digestibilityAnimals absorb more and waste less

Trials with pigs and broilers show anincrease in the absorption of both calciumand phosphorus with an increasinginclusion rate of RONOZYME® NP. Cost effective responses are achieved at inclusion rates of 150ppm and higher suggestinghigher inclusion rates will improveproducer profits. At current lowmarket prices for inorganicfeed phosphates, LCFprograms recommend aminimum of 200 ppm formeat poultry and pigs.

P Ca

Improvement in utilization of phosphorus in broilers

Example calculation based on full matrix valueincluding: Minerals, Amino Acids and Energy

12

11

10

9

8

7

Turkey/Broiler

150g/t RONOZYME® NP 200g/t RONOZYME® NP

Layer* Pig Piglet

1000

500

0 1.4

1.6

0RONOZYME® NP CT addition, g/t

150g/t 200g/t

1.8

2

Improved financialperformanceAnimals fed RONOZYME® NPgive better margins.

Diets containing RONOZYME® NP showpositive cost benefits across a range ofmatrix values and ingredient prices. Thesesavings increase at higher inclusion ratesof RONOZYME® NP with a today clearlyinteresting inclusion rate of 200g/tcompared to the classic dose of 150g/t.

Weight gain FCR

Weight gain in

the period, gram

FCR, Kg/Kg

500

450

400

350

300

250 1

1.2

0

RONOZYME® NP CT addition, g/t

150g/t 200g/t

1.4

1.6

Weight gain FCR

Weight gain in

the period, gram

FCR, Kg/Kg

France, 2007

100

80

60

40

2075°C

RONOZYME® NP Phytase P Phytase N

85°C 90°C 95°C

Recovery (%)

Cost savings

€/t feed

Denmark: 2009

Performance increase in turkeys

Performance increase in piglets

Improved animalperformanceAnimals fed RONOZYME® NPare more efficient

Daily liveweight gain and feed conversionratio (Kg feed/Kg lwt gain) are widelyaccepted measures of animalperformance in pig and poultry units withmore efficient animals achieving highweight gains and a better feed conversion.

Trials with RONOZYME® NP show thatsupplemented animals grew faster andwith superior feed conversion tounsupplemented animals. The advantages were more apparent at higher inclusion rates.

Better heat stabilityRONOZYME® NP is able to work in the animal.

Under the harsh conditionsexperienced in feed manufacture,

some enzymes can be degraded or destroyed.RONOZYME® NP (CT) with its improved CTformulation has outstanding heat stability upto 95°C. In addition it withstands attack bydigestive enzymes in the gut of the animal. It gets to where it benefits the animal.

RONOZYME® NP - The better phytase

Additional cost savingfrom 150g/t to 200g/t of

feed from 5% to 15%

5

* 60% of Broiler dose

RONOZYME®NP (CT) is the ideal choicefor pelleted feeds as it is the most heatstable phytase available. It has superiorhandling properties being virtually dustfree with excellent flowability andmixability.

RONOZYME®NP (M) is formulated forsystems where feed is mildly processed.It is safe and easy to handle for yourworkers, flows and mixes easily and isvirtually dust free. It is 5 times moreconcentrated than RONOZYME® NP (CT).

RONOZYME®NP (L) is the liquid form ofthe product which is ideally suited to postpelleting liquid applications. It is 2 timesmore concentrated than RONOZYME® NP(CT).

RONOZYME®

NP - the choice is yours

Recommended Inclusion Levels

RONOZYME® NP is available in three different forms, making it ideal for use inthe full range of feed manufacturing systems.

Additional regulatory information is available from DSM Nutritional Products´ eCommerce website:

https://webshop.dsm.com/wwwasera/html

6

The optimal dose of RONOZYME®NP may vary dependent on the species and stage of production. Please contact your DSM representative for further details.

RONOZYME®NP (CT) RONOZYME® NP (M) RONOZYME® NP (L)g/t feed g/t feed g/t feed

Broilers 150-300 30-60 75-150

Layers 90-150 18-30 45-75

Layer breeders 90-150 18-30 45-75

Ducks 150-300 30-60 75-150

Piglets 150-300 30-60 75-150

Growing/finishing pigs 150-300 30-60 75-150

Turkeys 150-300 30-60 75-150

Black Cyan Magenta Yellow CUTTER GUIDE DO NOT PRINT

DSM Nutritional Products

RONOZYME® NPThe better phytase

DSM Nutritional Products Ltd PO Box 2676

CH-4002 Basel

Switzerland

www.dsmnutritionalproducts.com

For DSM, quality is a way of life. This is the core of Quality for Life™.

Quality for Life™ is the mark of quality, reliability and traceability. It means that DSM customers are getting the best

nutrition & health ingredients, knowing the source on which they depend.

Quality for Life™ means sustainability. It symbolizes our commitment to our environment, consumer, our business

partners, our people and the regulatory framework that governs our operations.

With the Quality for Life™ seal, we provide peace of mind for you and for your customers.

Unlimited.DSM

TM

52000

© D

SM

Nut

ritiona

l Pro

duc

ts L

td• Produced by Mardle Consulting • D

esigned by mono design • www.monodesign.co.uk • 10/2009

Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the

accuracy, reliability, or completeness of the information. The information provided herein is for informational purposes and is intended for business to business use

only. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, either

expressly or implied. In no event shall DSM be liable for any damages arising from the reader's reliance upon, or use of, these materials. The reader shall be solely

responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contact

your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlands

and/or other countries.