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DuPont Asana ® XL insecticide DuPont™ Asana ® XL insecticide controls a wide range of insect pests that have economic impact on major field, vegetable, tree fruit and nut crops. Technical Bulletin

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DuPont™ Asana® XLinsecticide

DuPont™ Asana® XL insecticide controls a wide range of insect pests that

have economic impact on major field, vegetable, tree fruit and nut crops.

Technical Bulletin

Table of ContentsIntroduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1Formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1Pyrethroid Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2DuPont™ Asana® XL Insecticide Physical and Chemical Properties . . . . . . . . . . . .3Mode of Action on Insects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4

Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4Direct Contact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4Ingestion of Sprayed Foliage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4

Partial Listing of Insects Controlled by Asana® XL . . . . . . . . . . . . . . . . . . . . . . . .5–7Current U.S. Tolerances for Asana® XL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8Performance Characteristics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9

Longer Residual Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10–12Improved Formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13–14Resistance to Washoff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15High Temperature Effectiveness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16Crop Safety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16

Compatibility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16Mixes in Water . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16Mixes in Vegetable Oils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16Tank Stability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17

Ecological Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18Environmental Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18Environmental Hazards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18Toxicity to Fish . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18Toxicity to Bees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19Environmental Fate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19Metabolism of Esfenvalerate in Plants and Animals . . . . . . . . . . . . . . . . . . . . .19

Asana® XL Toxicology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20Acute Toxicity Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21Subchronic, Chronic and Neurotoxicity Studies . . . . . . . . . . . . . . . . . . . . . . . .21Mutagenicity and Genetic Toxicity Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21Carcinogenicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21

Material Safety Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21Health, Safety and Handling Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21Hazardous Reactivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22Fire and Explosion Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22Special Fire Fighting Instructions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22Other Physical Hazards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22NFPA Rating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22Spills, Leaks or Releases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23Waste Disposal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23Shipping Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23Returnable Bulk Container Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24Storage Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24

Personal Precautions, Symptoms and Treatment . . . . . . . . . . . . . . . . . . . . . . . . . .24Health Hazards and Protection Information . . . . . . . . . . . . . . . . . . . . . . . . . . . .24

Effects of Overexposure/First Aid Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Ingestion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Inhalation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Eye Contact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Skin Contact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Medical Emergencies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .26

IntroductionDuPont™ Asana® XL insecticide controls a wide range of insect pests that have economic impact on major field, vegetable, tree fruit and nut crops. Moreover,insect control is accomplished without phytotoxicity. The U.S. label includes more than 50 crops.

Each gallon of Asana® XL is formulated with approximately 2 quarts of cottonseed oil.Research on this formulation has demonstrated that the addition of cottonseed oilextends residual activity and makes Asana® XL more resistant to washoff.

For the grower, these attributes can contribute to improved financial returns. In addition, the low dosage rates and longer spray intervals minimize the amount of chemical introduced into the environment.

Asana® XL is an environmentally sound insecticide. It is a synthetic version ofpyrethrin, a naturally occurring insecticide derived from chrysanthemums.

FormulationAsana® XL insecticide is formulated as an emulsifiable concentrate (EC) containing0.66 pound of active ingredient (esfenvalerate) per gallon.

Active ingredient — esfenvalerate (by weight): 8.4 percent

Inert ingredients (by weight): 91.6 percent

Environmental Protection Agency (EPA) Reg. No. 352-515

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Pyrethroid ChemistryThe insecticidal properties of pyrethrins, which are derived from the flowers ofChrysanthemum cinerariaefolium and several other members of the same genus,have been known for more than 100 years. Figure 1 shows the chemical structureof a major component in natural pyrethrins.

Pyrethrins boast several distinctions — low mammalian toxicity, high toxicity to abroad spectrum of insects at very low dosages and minor environmental impact.Commercial uses range from household to industrial insect control.

Unfortunately, pyrethrins are costly and therefore are frequently formulated with a synergist (e.g., piperonyl butoxide) to reduce application rates. The rapid pho-todegradation of pyrethrins further limits their agricultural use. However, the desir-able properties of natural pyrethrins encouraged scientists to synthesize economi-cal, sunlight-stable, chemically related compounds (pyrethroids) that would exhibitsimilarly favorable low mammalian toxicity and high insecticidal activity.

After the initial success of allethrin in 1949, scientists strived to improve pyrethroidchemistry. Worldwide efforts culminated in the commercial development of severalcompounds for agricultural use, including permethrin, cypermethrin, deltamethrin,tralomethrin and fenvalerate.

Further investigation of fenvalerate chemistry led to the identification of the mostinsecticidally active isomer that would improve desired attributes. These attributesincluded much lower use rates for broader crop applications, no crop injury to sensi-tive crops, sunlight stability and effectiveness over wide temperature variations. Thisisomer, called esfenvalerate, is the insecticidal ingredient of DuPont™ Asana® XL.

In today’s highly competitive pyrethroid market, some manufacturers promote theirproduct as a “new generation” pyrethroid. This is a marketing tool that is used tomake their product appear newer and better. Most of the pyrethroids currently on themarket in the United States were patented before 1981 — more than 20 years ago!

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FIGURE 1:

NATURAL PYRETHRIN

Pyrethroid insecticidesCommon name Brand namesEsfenvalerate Asana® XLBifenthrin Capture, Brigade, Empower, DisciplineCyfluthrin Baythroid, Renounce, Tempo, AztecCypermethrin Ammo, UP-Cyde, Fury*, Mustang*, Mustang Max*, DemonCyhalothrin Karate**, Warrior**, ProAxis†, Silencer**Permethrin Pounce, Ambush, Waylay, Perm-UPDeltamethrin Decis

* Fury, Mustang and Mustang Max are zeta-cypermethrin.** Karate, Silencer and Warrior are lambda-cyhalothrin.

† ProAxis is gamma-cyhalothrin.

DuPont™ Asana® XL insecticide Physical and Chemical Properties Trade Name . . . . . . . . . . . . . . . . . . . . . . . . . . . .Asana® XL insecticide

Common Name . . . . . . . . . . . . . . . . . . . . . . . . .Esfenvalerate (BSI, ISO)

Chemical Name . . . . . . . . . . . . . . . . . . . . . . . . .(S)-cyano(3-phenoxyphenyl)methyl(S)-4-chloro-alpha-(1 methylethyl)-benzeneacetate

CAS Registry Number . . . . . . . . . . . . . . . . . . . .66230-04-4

Structural Formula

Empirical Formula . . . . . . . . . . . . . . . . . . . . . . .C25H22CINO3

Molecular Weight . . . . . . . . . . . . . . . . . . . . . . .419.9

Concentration . . . . . . . . . . . . . . . . . . . . . . . . . .0.66 lb ai/gal

Physical Form . . . . . . . . . . . . . . . . . . . . . . . . . .Clear liquid

Color . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Straw to light amber

Odor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Oily/aromatic

Density . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7.8 lbs/gal at 20°C (68°F)0.93 gm/ml at 20°C (68°F)

pH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5.14 (1% V emulsion in Type I reagent water)

Emulsibility (Concentration – 0.025 lb ai/gal)

In Soft Water (32 ppm as CaCO3) . . . . . . . . . .Good

In Medium Hard Water (342 ppm as CaCO3) . .Good

In Hard Water (900 ppm as CaCo3) . . . . . . . . .Good

Miscibility with Vegetable Oils . . . . . . . . . . . . .Miscible and stable in nonvolatile, refined vegetable oils

Formulation Stability . . . . . . . . . . . . . . . . . . . . .Stable for more than 21⁄2 years at room temperature (18–24°C or 65–75°F); for fourweeks at 54°C (130°F); for 26 weeks at 38°C(100°F), and ten weeks at 0°C (32°F) (basedon standard duration stability tests).

pH Stability . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Stable to hydrolytic degradation at environ-mentally relevant pH (pH 5–9)

log Kow (log Pow) . . . . . . . . . . . . . . . . . . . . . . .6.5

Vapor Pressure . . . . . . . . . . . . . . . . . . . . . . . . . .1.5 x 10-9 mm Hg @ 25°C

Water Solubility . . . . . . . . . . . . . . . . . . . . . . . . .0.002 mg/L @ 25°C

Koc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .251,700 mL/g 3

ACID FRAGMENT ALCOHOL FRAGMENT

FIGURE 2:

ESFENVALERATE

Mode of Action on InsectsSymptomsInsects sprayed with DuPont™ Asana® XL exhibit symptoms such as the following:

■ Hyperexcitation

■ Tremors

■ Convulsions

■ Lethargy

■ Paralysis

As the symptoms suggest, Asana® XL affects the insect’s nervous system. Asana® XLbinds to the sodium channel in the nerve cell and locks the channel open. Thisresults in repetitive firing of the nerves leading to the symptoms listed above.The insect is disoriented and its bodily functions fail because it cannot feed or move into protected areas. The exact type of symptoms that occur are linked to factors such as susceptibility of the insect species, the length of time betweenspraying and contact with the residue, and whether the exposure results fromdirect spraying, surface contact or ingestion.

Direct ContactAsana® XL can enter the insect directly through its cuticle, intersegmental membranes or other vulnerable areas, for example, the sensory structures on the exterior surface of the body. Direct contact with spray droplets is the mosteffective method of control because the insect is exposed to fresh, unaged residues.

Insects not contacted by the spray are exposed to residual spray deposits on thetreated crop foliage. Insects vary in the amount of contact they have with the plantduring their normal activities. This may partially explain the variations that exist inthe susceptibility of different species to Asana® XL.

Ingestion of Sprayed FoliageThe primary route of insecticidal entry is through direct contact with Asana® XLresidues during feeding. However, ingestion of treated crops adds to the intoxicationprocess, serving as another means of exposure.

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Partial Listing of Insects Controlled byAsana® XLThe following chart provides a partial listing of the common and scientific names of the pests controlled. Please consult the package label for complete registration information.

Common name Scientific name

Alfalfa caterpillar Colias eurytheme

Alfalfa looper Autographa californica

Apple aphid Aphis pomi

Apple maggot Rhagoletis pomonella

Armyworm Pseudaletia unipuncta

Artichoke plume moth Platyptilia carduidactyla

Aster leafhopper Macrosteles quadrilineatus

Banded cucumber beetle Diabrotica balteata

Banded sunflower moth Cochylis hospes

Bean leaf beetle Cerotoma trifurcata

Beet webworm Loxostege sticticalis

Black cherry aphid Myzus cerasi

Black cutworm Agrotis ipsilon

Black vine weevil Otiorhynchus sulcatus

Blueberry maggot Rhagoletis mendax

Blueberry spanworm Itame argillacearia

Boll weevil Anthonomus grandis grandis

Cabbage looper Trichoplusia ni

Celery looper Anagrapha falcifera

Cherry fruit fly Rhagoletis cingulata

Chinch bug Blissus leucopterus leucopterus

Codling moth Cydia pomonella

Colorado potato beetle Leptinotarsa decemlineata

Corn earworm Helicoverpa zea (formerly Heliothis zea)

Corn leaf aphid Rhopalosiphum maidis

Corn rootworm (adult) Diabrotica spp.

Corn silk fly Euxesta stigmatias

Cotton bollworm Helicoverpa zea

Cotton leafperforator Bucculatrix thurberiella

Cotton leafworm Alabama argillacea

Cranberry fruitworm Acrobasis vaccinii

Cucumber beetle Acalymna spp.

European corn borer Ostrinia nubilalis

Filbertworm Cydia latiferreana

Flea beetle Subfamily: Alticinae

Partial Listing of Insects Controlled by DuPont™ Asana® XL(continued)Common name Scientific name

Fleahopper (cotton) Pseudatomoscelis seriatus

Granulate cutworm Agrotis subterranea

Grasshoppers Family: Acrididae (key genus Melanoplus)

Green cloverworm Plathypena scabra

Green fruitworm Lithophane antennata

Green stink bug Acrosternum hilare

Heliothis Heliothis virescens

Hickory shuckworm Cydia caryana

Imported cabbageworm Pieris rapae

Japanese beetle (adult) Popillia japonica

Lesser appleworm Grapholita prunivora

Lesser peachtree borer Synanthedon pictipes

Lygus bugs Lygus spp.

Mexican bean beetle Epilachna varivestis

Mullein plant bug Campylomma verbasci

Nantucket pine tip moth Rhyacionia frustrana

Navel orangeworm Amyelois transitella

Oat-bird cherry aphid Rhopalosiphum padi

Obliquebanded leafroller Choristoneura rosaceana

Orange tortrix Argyrotaenia citrana

Oriental fruit moth Grapholita molesta

Painted lady butterfly (larvae) Vanessa cardui

Pea aphid Acyrthosiphon pisum

Pea weevil Bruchus pisorum

Peachtree borer Synanthedon exitiosa

Peach twig borer Anarsia lineatella

Pear psylla Cacopsylla pyricola

Pecan aphid (black/yellow) Melanocallis caryaefoliae/Monelliopsis pecanis

Pecan nut casebearer Acrobasis nuxvorella

Pecan phylloxera Phylloxera devastatrix

Pecan spittlebug Clastoptera achatina

Pecan weevil Curculio caryae

Periodical cicada Magicicada septendecim

Pickleworm Diaphania nitidalis

Plum curculio Conotrachelus nenuphar

Potato leafhopper Empoasca fabae

Redbanded leafroller Argyrotaenia velutinana

Rednecked peanutworm Stegasta bosqueella

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Partial Listing of Insects Controlled by Asana® XL (continued)

Common name Scientific name

Rindworm [complex] – Diaphania spp./and some species ofConsidered any caterpillar Family: Noctuidaethat feeds on melon rinds

Rosy apple aphid Dysaphis plantaginea

Saltmarsh caterpillar Estigmene acrea

Sap beetle [dusky] (adult) Carpophilus lugubris

Sorghum midge Contarinia sorghicola

Southern armyworm Spodoptera eridania

Southern green stink bug Nezara viridula

Southwestern corn borer Diatraea grandiosella

Soybean aphid Aphis glycines

Spittle bug Family: Cercopidae

Spotted tentiform leafminer Phyllonorycter blancardella

Squash bug Anasa tristis

Squash vine borer Melittia cucurbitae

Stalk borer Papaiema nebris

Stink bug Family: Pentatomidae

Sugarcane borer Diatraea saccharalis

Sunflower beetle Zygogramma exclamationis

Sunflower maggot Strauzia longipennis

Sunflower moth Homoeosoma electellum

Sunflower seed weevil Smicronyx spp.

Sunflower stem weevil Cylindrocopturus adspersus

Tarnished plant bug Lygus lineolaris

Tentiform leafminer [spotted] Phyllonorycter blancardella

Threecornered alfalfa hopper Spissistilus festinus

Tobacco budworm Heliothis virescens

Tobacco hornworm Manduca sexta

Tomato fruitworm Helicoverpa zea

Tomato hornworm Manduca quinquemaculata

Tomato pinworm Keiferia lycopersicella

Tufted apple bud moth Platynota idaeusalis

Variegated leafhopper Erthroneura variabilis

Velvetbean caterpillar Anticarsia gemmatalis

Walnut aphid Chromaphis juglandicola

Walnut husk fly Rhagoletis completa

Western bean cutworm Loxagrotis albicosta

Western cherry fruit fly Rhagoletis indifferens

White apple leafhopper Typhocyba pomaria

Woollybear caterpillar Family: Arctiidae7

Current U.S. Tolerances for DuPont™ Asana® XLThe following chart provides the current EPA-established tolerances for residues of Asana® XL in or on raw agricultural commodities (RAC’s). Tolerances are indicated in parts per million (ppm) of all isomers.

RAC PPM RAC PPM

Almond hulls 15.0 Kiwi 0.5

Almonds 0.2 Kohlrabi 2.0

Apples 2.0 Muskmelons 1.0

Artichokes 1.0 Mustard greens 5.0

Beans, dried 0.25 Peanuts 0.02

Beans, snap 2.0 Peanut hulls 0.1

Broccoli 2.0 Pears 2.0

Blueberries 3.0 Peas 1.0

Cabbage 10.0 Peas, dried 0.25

Caneberries 3.0 Pecans 0.2

Cantaloupes 1.0 Peppers 1.0

Carrots 0.5 Potatoes 0.02

Cauliflower 0.5 Pumpkins 1.0

Collards 10.0 Radish, roots 0.3

Corn, grain 0.02 Radish, tops 8.0

Corn, fodder 50.0 Sorghum, grain 5.0

Corn, forage 50.0 Sorghum, forage and fodder 10.0

Corn, sweet Soybeans 0.05

Kernels and cobs 0.1 Stone fruits 10.0

Cottonseed 0.2 Sugar beet, pulp 2.5

Cucumbers 0.5 Sugar beet, root 0.5

Currants 3.0 Sugar beet, tops 5.0

Eggplant 1.0 Sugarcane 2.0

Elderberries 3.0 Summer squash 0.5

English walnuts 0.2 Sunflower seeds 1.0

Filberts 0.2 Tomatoes 1.0

Gooseberries 3.0 Turnip, roots 0.5

Head lettuce 5.0 Turnip, tops 20.0

Honeydew melons 1.0 Watermelons 1.0

Huckleberries 3.0 Winter squash 1.0

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Performance CharacteristicsInsects exposed to Asana® XL stop feeding almost immediately, thus preventingfurther damage to the crop. However, the lethal effects of Asana® XL may not beapparent until 72 hours after application. Because of this performance characteristic,premature evaluation of Asana® XL treatments can lead to the erroneous conclusionthat insect control has not been achieved. Conduct post-treatment scouting 72 hours after an application to avoid unnecessary retreatment.

Some insects are known to develop resistance to products used repeatedly forcontrol. For example, Heliothis virescens (tobacco budworm) has developed someresistance to pyrethroid insecticides in certain areas. The use of Asana® XL shouldconform to resistance management strategies established in the use area. Due toresistance in some areas, a pyrethroid alone may not provide adequate control. If youexperience difficulty with insect control while using this product, consult your localDuPont representative, agricultural advisor or university Extension specialist forspecific control recommendations.

The judicious use of pesticides demands adopting a sensible integrated pest management (IPM) approach. Consider the condition and stage of crop growth in conjunction with the levels of insects present — both pests and beneficial species.

In some crops, beneficial insects are able to keep pest populations below the economic threshold. Frequent and detailed observations are needed to determinewhen economic thresholds are exceeded and chemical control is required. Thecombination of label information and detailed scouting will indicate if and whenAsana® XL needs to be applied and the appropriate rate.

It is generally accepted that variable rates of Asana® XL may be used, dependingupon timing and insect pressure. Rigid spray schedules are not recommendedbecause they are not sound economical or ecological practices. Rational timing ofAsana® XL treatments and use of a sufficient dosage, within label recommendations,to bring pest populations under control are essential. Insect control objectivesshould be set at a level that achieves the maximum economic return while minimizingenvironmental impact.

For cotton, sweet corn, cole crops and other crops that require multiple applicationsover a period of several weeks to control insect populations, make the initial one or two applications of Asana® XL at intermediate to high labeled rates. This practiceestablishes a residual deposit on the plants that will control heavy insect infestations.After insect populations are under control, the use of lower labeled rates usuallycontrols light to moderate infestations. Also consider rotating to an insecticide in a different class of chemistry (such as DuPont™ Lannate®, Avaunt® or Steward®)with a different mode of action to minimize the potential for developing insect populations that are resistant to pyrethroids.†

† DuPont™ Lannate®, Avaunt® and Steward® are not labeled for use on all crops mentioned above. You must refer to the product label for each product for a complete listing of crop/pest combinationscontrolled or suppressed.

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Longer Residual Activity Although a number of factors can affect pyrethroid performance (e.g., rainfall and temperature), research studies have documented that the ultraviolet (UV) rays in sunlight are the primary cause of pyrethroid breakdown. Compared to other pyrethroid products, the chemical structure of DuPont™ Asana® XL offers anadvantage in the area of photostability.

All pyrethroids consist of an alcohol fragment or moiety that is combined with anacid fragment. The reaction of the alcohol fragment (ending in –OH) with the acidfragment (carboxyl or COOH) releases water and forms a very stable ester molecule.

The structure of the alcohol moiety is similar in most commercial pyrethroid products.However, there are important differences between Asana® XL and other pyrethroidsin terms of the chemical structure of the acid fragment. Specifically, the arrange-ment of the Asana® XL molecule makes it much more stable and less vulnerable to UV degradation.

Permethrin (Ambush and Pounce), Cypermethrin (Cymbush and Ammo), Baythroid,Capture, Decis, Fury, Karate, Mustang and Warrior all bond the alcohol fragmentwith a vinyl substituted cyclopropyl acid. This vinyl cyclopropyl acid fragment ofthe molecule is characterized by a carbon-to-carbon double bond. This chemistry,while insecticidally active, is susceptible to UV degradation. Because of the instabilityof the vinyl cyclopropyl double bond region when exposed to sunlight, the moleculebreaks apart at this point. The UV-chemical reaction then denatures the pyrethroidmolecule.

In Asana® XL, the acid-alcohol bond is achieved using an isopropyl benzyl acid.This unit lacks the carbon-to-carbon double bond present in Ambush, Pounce,Baythroid, Capture, Decis, Fury, Karate, Mustang, Warrior and Cypermethrin.Although the acid fragment of the molecule is still vulnerable to sunlight breakdown,the process is much slower due to the lack of the double bond.

Figure 3 shows the results of a DuPont trial that compared the photostability ofAsana® XL and competitive pyrethroids. The chemical half-life of Asana® XL isalmost twice as long as any of its competitors when they are applied to glassplates and exposed to artificial sunlight.

10

0

20

40

60

80

100FIGURE 3:

STABILITY OF ASANA® XLINSECTICIDE AND COMPETI-TIVE PYRETHROIDS EXPOSEDTO ARTIFICIAL (XENON ARC)SUNLIGHT (APPLIED ATINSECTICIDALLY EQUIVALENTRATES).

ESTIMATED HALF-LIFE, DAYS

ASANA® XL 13.5CAPTURE 7.8BAYTHROID 4.0KARATE 2.5 P

ERC

ENTA

GE

OF

AP

PLI

ED A

.I. R

EMA

ININ

G

EXPOSURE TIME, DAYS (24 HOURS)

0 2 4 6 8 10 12 14

ASANA® XLCAPTUREBAYTHROIDKARATE

Figures 4 and 5 show the results of laboratory/greenhouse trials conducted with anumber of commercial pyrethroid formulations to determine comparative residualactivity. In Figure 4, paired soybean plants were treated at insecticidally equivalentrates. After the spray deposits had dried, half the plants were bioassayed at 24 hoursafter treatment. A second set of plants was held for 7 days and then bioassayed. All plants were bioassayed for control of corn earworm (Helicoverpa zea) larvae. The loss of activity after 7 days was calculated by comparing the toxicity of thedeposit remaining on the plant 24 hours after application versus the toxicity of thedeposit on the plants held for 7 days. The results were expressed as the percent of active residue remaining after 7 days for each product. Warrior was the most affected after 7 days, losing at least 75 percent of its original activity. Asana® XL wasleast affected after 7 days with more than 50 percent of the original activity remaining.

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FIGURE 4:

RESIDUAL ACTIVITY OF ASANA® XL AND COM-PETITIVE PYRETHROIDS ONCORN EARWORM.

PYRETHROID RESIDUALCorn Earworm LC50

Percent active residue remaining at 7 days

ASANA® XL

CAPTURE

AMMO

FURY

BAYTHROID

WARRIOR

STINE HASKELL RESEARCH CENTER2001 DATA

0 10 20 30 40 50

Figure 5 shows the results for a similar trial conducted with cabbage looper (Trichoplusia ni) on cabbage plants. In this trial Pounce and Ammo were the most affected after 7 days, losing more than 90 percent of their original activity. DuPont™ Asana® XL was least affected, retaining more than 25 percent of its original activity.

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FIGURE 5:

RESIDUAL ACTIVITY OF ASANA® XL AND COMPETITIVE PYRETHROIDSON CABBAGE LOOPER.

PYRETHROID RESIDUALCabbage Looper LC50

Percent active residue remaining at 7 days

ASANA® XL

CAPTURE

AMMO

FURY

BAYTHROID

WARRIOR

STINE HASKELL RESEARCH CENTER2001 DATA

0 10 20 30 40

POUNCE

Improved FormulationIn efforts to improve photostability, DuPont researchers experimented with a number of different formulations, trying to block the effects of the sun’s rays. They discovered that formulating it with cottonseed oil (CSO), which has a sunscreen-like effect, could extend the residual life of Asana® XL.

The fatty acids in cottonseed oil absorb UV light, protecting Asana® XL from certain wavelengths that break it down. Other ingredients that act as a sunscreenalso are included in the formulation. As noted in Figure 6, DuPont research shows the Asana® XL formulation with cottonseed oil is much more resistant to sunlightbreakdown than an earlier formulation of the same compound (Asana® 1.9) or conventional EC formulations of similar products.

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0

20

40

60

80

100

FIGURE 6:

STABILITY OF ASANA® XLINSECTICIDE AND COMPETITIVEPYRETHROIDS ON GLASS PLATESEXPOSED TO NATURAL SUN-LIGHT (APPLIED AT INSECTICI-DALLY EQUIVALENT RATES).

ESTIMATED HALF-LIFE, DAYSASANA® XL 7.5ASANA® 1.9 2.3CYMBUSH 0.5AMMO 1.1BAYTHROID 0.5SCOUT 0.9P

ERC

ENTA

GE

OF

AP

PLI

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.I. R

EMA

ININ

G

EXPOSURE TIME, DAYS (24 HOURS)

0 2 4 6 8 10 12

ASANA® XLASANA® 1.9AMMOSCOUTCYMBUSHBAYTHROID

Figure 7 shows the results of a DuPont laboratory/greenhouse trial conducted withsix commercial pyrethroid formulations to determine comparative UV (ultraviolet) light stability. Paired cotton plants were treated at insecticidally equivalent rates.After the spray deposits had dried, half the plants were held in a dark growthchamber while the other half were exposed to 24 hours of high-intensity, simulatedsunlight (equivalent to three days exposure in the field). All plants were then bioassayed for control of tobacco budworm larvae (Heliothis virescens). The loss of activity was calculated by comparing the toxicity of the deposit remainingon the plant exposed to simulated sunlight versus the toxicity of the deposit on the plants held in the dark. The results are expressed as the percent of original activityremaining after 24 hours of simulated sunlight for each product. Baythroid and Warrior were most affected by exposure to simulated sunlight, losing at least 30 percent of their original activity. DuPont™ Asana® XL was least affected by the simulated sunlight with more than 85 percent of the original activity remaining.

Similar results have been reported from comparative photostability tests on cottonplant leaves exposed to natural sunlight. The improved residual performance ofAsana® XL helps growers reduce the number of spray applications, with the benefitsof lower labor, equipment and chemical costs.

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FIGURE 7:

ASANA® XL RESISTANCE TOUV DEGRADATION

INSECTICIDAL ACTIVITY OFTHE DEPOSIT REMAINING ONTHE PLANT AFTER EXPOSURETO 24 HOURS OF SIMULATEDSUNLIGHT.

PYRETHROID UV STABILITYPercent of original activity remaining

after 24 hours in UV chamber

ASANA® XL

CAPTURE

AMMO

FURY

BAYTHROID

WARRIOR

STINE HASKELL RESEARCH CENTER2001 DATA

50 60 70 80 90 100

Resistance to WashoffAnother important criterion for the Asana® XL formulation is resistance to washoff.Ongoing field and laboratory tests have verified that adding cottonseed oil to theformulation not only increases photostability but also helps the insecticide adhereto plant foliage.

As individual spray droplets of Asana® XL dry, a protective film of cottonseed oil andAsana® XL forms. This protective film, which is extremely resistant to water, ensuresthat the insecticidally active pyrethroid residues will remain on the plant. Once thespray deposit has dried, Asana® XL resists washoff from rainfall, dew or irrigationbetter than competitive pyrethroids formulated with petroleum-based solvents.

Figure 8 shows the results of a laboratory/greenhouse trial conducted with sixcommercial pyrethroid formulations to determine resistance to washoff. Paired cotton plants were treated at insecticidally equivalent rates. After the spray depositshad dried, half the plants were exposed to a 2-inch simulated rainfall (applied at 1 inch per hour). All plants were then bioassayed for control of tobacco budworm larvae (Heliothis virescens). The loss of activity was calculated by comparing thetoxicity of the deposit remaining on the plant exposed to rainfall versus the toxicityof the deposit on the plant not exposed to rainfall. The results are expressed as thepercent of original activity remaining after 2 inches of simulated rainfall for eachproduct. Fury and Warrior were most affected by washoff, losing more than 65 percent of their efficacy. Asana® XL was least affected by the simulated rainfallwith more than 50 percent of the original activity remaining. Field entomologistshave also observed that the insect control properties of Asana® XL are maintainedeven if treatments are followed by sprinkler irrigation or heavy rainfall.

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FIGURE 8:

ASANA® XL RESISTANCE TO WASHOFF

INSECTICIDAL ACTIVITY OF THESPRAY DEPOSIT REMAININGON THE PLANT AFTER EXPOSURE TO A 2-INCH SIMULATED RAINFALL.

PYRETHROID WASHOFFPercent of original activity remaining after

2 inches simulated rainfall

ASANA® XL

CAPTURE

AMMO

FURY

BAYTHROID

WARRIOR

STINE HASKELL RESEARCH CENTER2001 DATA

10 20 30 40 50 60

High Temperature EffectivenessIn field applications on cotton, DuPont™ Asana® XL has demonstrated outstandingactivity over a wide range of temperatures and climatic conditions. Observationsindicate that even at high temperatures Asana® XL maintains its effectiveness.

Crop SafetyAsana® XL has been shown to be noninjurious to a wide range of field, tree andvegetable crops when used in accordance with the label. Multiple applications,even at maximum labeled rates, are not phytotoxic to leaves or fruit.

CompatibilityMixes in WaterAsana® XL may be tank mixed in a water carrier with most other pesticides, includingDuPont™ Avaunt®, Lannate®, Steward® and Vydate® insecticides, or with certain herbicides when insect populations require control concurrent with the need forweed control. Laboratory evaluations indicate that most other pesticides likely tobe tank mixed in a water carrier will be compatible with Asana® XL. Always checkall applicable labels and conduct a test for physical compatibility before makingand applying field mixtures.

To conduct a test for compatibility, add proportionate amounts of Asana® XL andeach ingredient of the intended tank mixture to a pint or quart jar. After capping the jar, shake it and allow the mixture to stand for 15 minutes. If precipitates formthat are not readily redispersed, the mixture is incompatible and should not be used.

Mixes in Vegetable OilsThe growing practice of ultra-low-volume (ULV) oil application techniques hasraised questions about pesticide tank-mix compatibility in vegetable oils. To date,laboratory evaluations show that most pesticides sold as emulsible concentrateswill be compatible with Asana® XL in vegetable oil.

Mixtures of solid formulations, water-dispensable suspensions and certain solutionformulations in water-miscible solvents are likely to generate mixing, homogeneityand spraying problems with Asana® XL in vegetable oil. This is a function of the solidpesticide formulations and oil and is not a problem brought about by the presence ofAsana® XL in the mixture. Again, it is good practice to perform the standard physicalcompatibility test described above before mixing large volumes in a spray tank.

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Tank StabilityAsana® XL should be applied as soon as possible following preparation to avoidthe possibility of product degradation. However, equipment breakdown, suddenrain, high winds and other environmental factors can delay or interrupt insecticideapplications. When a job must be postponed, the unused spray solution is left sitting in the equipment until the situation improves enough to continue with theapplication. This can extend into a period of days, during which time the tank mix can decompose and be ineffective when spraying is resumed.

The chemical stability of a pesticide in a tank mix is primarily dependent on thetemperature and the tank mix pH. The pH of the tank mix is not necessarily thesame as the source water since most formulations contain chemicals that willchange the pH. Knowing the pH and temperature of the tank mix during the delay,the following graph can be used to determine the approximate percent of Asana® XLremaining after the delay. Asana® XL exhibits excellent tank stability under a widerange of tank pH (see Figure 9). In addition, spray tank temperature does not affectAsana® XL stability appreciably over the standard tested range of 32º F to 113º F.Many insecticides do not exhibit this degree of stability.

The graph only represents the activity of Asana® XL in water and does not apply toany added tank-mix partner. In all cases, tank mixes should be thoroughly agitatedbefore spraying is resumed. This information is intended as a guide for understandingthe tank stability of Asana® XL and is not to be used to determine if, or how much,pesticide should be added to an existing tank mix after a time delay, or as a guideto determine how far in advance a tank mix can be prepared.

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100

72

76

80

84

88

92

96

320 1

STABILITY OF ASANA® XL

PER

CEN

T A

SA

NA

®X

L R

EMA

ININ

G

DAYS

pH=9pH=7pH=5

FIGURE 9:

TANK STABILITY

SUMMARY OF PERCENTASANA® XL REMAINING INTANK DEPENDENT UPON pH.

Ecological EffectsEnvironmental ImpactToxicological and environmental fate data indicate that esfenvalerate has a minimalenvironmental impact on both man and the environment when applied at recommended use rates in accordance with label directions. Phytotoxicity fromesfenvalerate has not been observed in any plant studies. The compound is chemically very stable and degrades to known and understood metabolites. Esfenvalerate binds very tightly to soil, and its binding properties increase proportionally to the organic content of the soil (average Koc=251,700). The compound is very insoluble in water (less than 2 ppb). These factors make it highly unlikely that DuPont™ Asana® XL will move into groundwater or wash off-site to surface waters.

Environmental HazardsAsana® XL is a restricted-use pesticide because it is extremely toxic to fish andaquatic invertebrates. Use with care when applying in the vicinity of any body ofwater. Do not apply directly to water or when weather conditions favor drift fromtreated areas. Do not apply Asana® XL by ground within 25 feet, or by air within150 feet of lakes, reservoirs, rivers, permanent streams, marshes, natural ponds,estuaries or commercial fish-farm ponds. Increase the buffer zone to 450 feet when ultra-low volume (ULV) application is made. Do not contaminate water whendisposing of equipment wash waters. Do not apply to blooming crops if bees arevisiting the treatment area. Apply this product only as specified on the label.

Toxicity to Fish Although laboratory tests have demonstrated that Asana® XL is extremely toxic tofish and aquatic invertebrates, these tests were conducted under conditions wherethe concentrations of Asana® XL were maintained throughout the test. Under naturalconditions, the level of Asana® XL is likely to decrease rapidly due to the very highbinding affinity of Asana® XL for organic matter in water, soil or sediment, therebydecreasing its availability to fish and zooplankton. Rapidly diminishing concentrationsof Asana® XL mitigate the level and duration of potential toxicity of fish and aquaticinvertebrates in aquatic habitats.

Large-scale field mesocosm studies using quarter-acre ponds have confirmed thatunder natural conditions, toxicity of Asana® XL to fish and aquatic invertebrates is lower than predicted from laboratory studies. When ponds containing naturalassemblages of algae, invertebrates and fish were treated with repeated applicationsof Asana® XL simulating both drift (up to 20 percent of the maximum field use rate)and runoff (up to 37 percent of the maximum field use rate), no detrimental effectswere observed for algae or fish. The populations of some aquatic invertebrates inthe ponds were negatively affected, but the effects were transient and longer-termeffects were only seen for sediment-dwelling invertebrates and then only at thehighest concentrations tested.

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Toxicity to BeesAsana® XL is highly toxic to bees directly exposed to applications. However, oncethe foliar residues have dried, the hazard is insignificant. Thus, Asana® XL can beused on a blooming crop if applied when bees are not actively foraging. The besttime for treatment is either early morning or evening. Due to the bee repellenteffect, bee visitations can be expected to drop slightly for one day and then return tonormal. By following these application guidelines, growers will see effective insectcontrol with little or no interruption of bee activity to pollination-dependent crops.

Research has confirmed that bees do not carry Asana® XL back to the hive in quantities that either weaken the hive or predispose it to loss during the winter. In addition, dried spray residues of Asana® XL will not become resuspended or dissolved in dew, unlike some other pesticides, further reducing the hazard ofAsana® XL to bees.

Environmental FateWater: Esfenvalerate is stable in acid or neutral water but degrades via hydrolysisin alkaline water. When aqueous solutions were exposed to light, it degraded rapidlywith a half-life of 4 days in summer and 13 to 15 days in winter.

Soil: In soils, the rate of degradation is dependent on the nature of the soil. Lightfurther assists the degradation of esfenvalerate in soil. Half-lives averaging 10 dayswere observed in soil photolysis experiments. Due to its affinity for organic material,there is no leaching of this compound in soil.

Metabolism of Esfenvalerate in Plants and AnimalsThe metabolism of esfenvalerate has been extensively studied in plants and animals.In plants, esfenvalerate showed very little systemic absorption and translocationafter foliar application. Esfenvalerate that does enter the plant, degrades by photolyticdecarboxylation reaction, ester cleavage and subsequent conjugation of the cleavedproducts with glucose. In animals, esfenvalerate is extensively metabolized andrapidly excreted. The major metabolic reaction is ester cleavage and hydroxylationat the alcohol moiety.

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DuPont™ Asana® XL ToxicologyEPA Toxicity

Acute Toxicology1,2 Asana® XL Category

Acute OralLD50 Rat 458 mg/kg (moderately toxic) II

Acute DermalLD50 Rabbit >2000 mg/kg (moderately toxic) III

Acute InhalationLC50 Rat >2.93 mg/L (4 hours — moderately toxic) III

Eye ContactRabbit minimally irritating IV

Skin ContactRabbit not an irritant IVGuinea pig not a sensitizer

Avian Asana® Technical (mg/kg)

Mallard duckLD50 >2250 (very low to slightly toxic)

Bobwhite quailLD50 381 (moderately toxic)

Aquatic Asana® Technical (ug/L, ppb)

Rainbow troutLC50 0.26 (96 hours — extremely toxic)

Bluegill sunfishLC50 0.26 (96 hours — extremely toxic)

CarpLC50 1.34 (48 hours — extremely toxic)

Daphnia magnaLC50 0.90 (48 hours — extremely toxic)

1LD50 is the dose of chemical per kilogram of body weight that is lethal to 50 percent of the animals tested.2LC50 is the concentration of material in air or water that is lethal to 50 percent of the animals tested.

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Acute Toxicity StudiesAsana® XL is moderately toxic via oral, dermal and inhalation exposures. Exposureto near lethal concentrations has produced neurological effects in laboratory animals.Such exposures are not reached when the product is used in accordance with theproduct label. Contact with the concentrate produced minimal eye irritation thathad reversed in three days. It is not a primary skin irritant nor a sensitizer. However,contact with skin has resulted in a transient burning or prickling sensation that maylast from a few minutes to approximately 24 hours. This sensation is usually notaccompanied by visible irritation or a rash and is common to many pyrethroidinsecticides. Vitamin E oil or cream has been shown to offer relief from this effect.

Subchronic, Chronic and Neurotoxicity StudiesEsfenvalerate has been thoroughly evaluated in laboratory toxicity tests. Esfen-valerate does not produce any significant target organ toxicity in animals following repeated dosing by feeding or application to the skin. It has not beendemonstrated to be a reproductive toxin or a developmental toxin in laboratory animals. These tests were also negative for neurological lesions or significanteffects on other tissues.

Mutagenicity and Genetic Toxicity StudiesEsfenvalerate does not produce genetic damage. It was negative in all tests for thiseffect, including gene mutation tests in S. typhimurium (Ames Test), E. coli and inChinese hamster ovary (CHO) cells; in vitro chromosome aberration test in CHOcells; mouse micronucleus test; and the unscheduled DNA assay in HeLa cells.

CarcinogenicityLifetime studies in rodents with fenvalerate or esfenvalerate were negative for carcinogenic effects. Esfenvalerate has been classified by the EPA as: evidence of noncarcinogenicity for humans.

Material Safety InformationConsult the Material Safety Data Sheet (MSDS) for more information.

Health, Safety and Handling InformationOnly certified applicators or persons working under their direct supervision can useAsana® XL. Only those uses covered by the certified applicator’s certification arepermitted. Safety in handling, storing and applying Asana® XL is the responsibility ofeach individual who works with it. Prior to using Asana® XL, refer to the productlabel for more information on its use. In addition, observe the precautions outlinedin the following sections whenever you are working with Asana® XL.

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Hazardous Reactivity Instability: Stable at normal temperatures and storage conditions.

Decomposition: Hydrogen cyanide may be formed by thermal decomposition orreaction with alkaline materials.

Polymerization: Polymerization will not occur.

Incompatibility: Avoid heat, flame and contact with strong oxidizing agents.

Fire and Explosion DataThe flash point for DuPont™ Asana® XL is 150º F (TCC). Heating can release vaporsthat can be ignited. Hazardous gases/vapors produced in fire are toxic and mayinclude hydrogen cyanide. Extinguishing media are water spray, water fog, drychemical and CO2.

Special Fire Fighting Instructions■ Evacuate personnel to a safe area.

■ Wear self-contained breathing apparatus.

■ Wear full protective equipment.

■ Use water spray; cool tank/container with water spray.

Other Physical Hazards■ Use explosion-proof ventilation as required to control vapor concentrations.

■ Keep liquid and vapor away from heat, sparks or flame. Hot surfaces may igniteliquid product even in the absence of sparks or flame.

■ Extinguish pilot lights and cigarettes; turn off other sources of ignition prior touse and until all vapors are gone.

■ Do not cut, drill, grind, or weld on or near container. Emptied containers cancontain explosive vapors.

NFPA RatingHealth 1

Flammability 2

Reactivity 0

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Spills, Leaks or Releases*

Small Spills

■ Soak up with absorbent material and place in nonleaking containers for proper disposal.

■ Do not use alkaline absorbent because Asana® XL can react to form hydrogencyanide.

■ Use diking to ensure that water sources are not contaminated.

Large Spills

■ Eliminate potential sources of ignition.

■ Wear appropriate respirator and other protective clothing.

■ Shut off source of leak only if safe to do so.

■ Dike and contain. Remove with vacuum trucks or pump to storage/salvage vessels.

■ Soak up residue with an absorbent such as clay, sand or other suitable material.Place in nonleaking containers and seal tightly for proper disposal.

■ Do not use alkaline absorbent because Asana® XL can react to form hydrogencyanide.

■ Flush area with water to remove trace residue; dispose of flush solution asdescribed above.

* Note: Review the sections on “FIRE AND EXPLOSION DATA” and “HEALTH HAZARDS” before proceeding with clean up. CAUTION — COMBUSTIBLE!

In case of a significant spill, call CHEMTREC: 1-800-424-9300

Waste Disposal■ Place in a disposal facility approved under Resource Conservation and Recovery

Act (RCRA) Regulations for hazardous waste.

■ Use nonleaking containers, seal tightly and label properly.

Improper disposal of excess pesticide, spray mixture, or rinsate is a violation offederal law. If these wastes cannot be disposed of according to label instructions,contact your State Pesticide or Environmental Control Agency or the hazardouswaste representative at the nearest EPA Regional Office for guidance.

Shipping InformationAsana® XL is classified by the Department of Transportation (DOT) as: Pesticide Liq-uid, Toxic, N.O.S. (esfenvalerate), 6.1., UN 2902, PG111. If shipped by water or bulk(more than 119 gallons per single package), add: Marine Pollutant.

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Returnable Bulk Container SystemsTo assist in the task of proper handling and disposal of containers, DuPont offersDuPont™ Asana® XL in 14- and 110-gallon returnable container systems.

The 14-gallon stainless steel container is equipped with a Micromatic Macro-Valvedry-break male fitting. The 110-gallon plastic returnable tank is equipped with aMicromatic Drum Valve dry-break male fitting. Both systems are evacuated usingcustomer-owned pump and meter systems. For low volume users, the Tuthill/SoteraSeries 35 volumetric hand pump is recommended. For high volume users, the Murray Tru-Force 12-volt electric pump/meter system is recommended. Otherpump/meter systems have also been used successfully. Due to the Asana® XL formulation, all pump systems should use Viton gaskets for maximum longevity.

After the 14- or 110-gallon container is empty, simply return it to DuPont throughan approved agrichemical supplier. This eliminates the time-consuming and expensive decontamination and disposal process now faced by consumers.

Storage Conditions■ Store Asana® XL in a secure, dry and temperate area in the original container.

■ Keep the container closed when not in use.

■ Do not use or store around the home or near food or feed.

■ Avoid contact with water.

Asana® XL insecticide is shelf-stable for more than 21⁄2 years under normal storageconditions. This period is accurate both with respect to retention of active componentand maintenance of acceptable emulsibility properties.

Personal Precautions, Symptoms and TreatmentHealth Hazards and Protection Information Warning! Asana® XL may be fatal if swallowed and harmful if inhaled.(Please see page 21 for Acute Toxicity Study information)

■ Avoid breathing vapors or mist; do not get in eyes, on skin or on clothing.

■ Use Asana® XL only with adequate ventilation. Wear goggles or a face shield,protective clothing and rubber gloves (as specified by the label) when handling.

■ Wash thoroughly with soap and water after handling and before eating, drinking,chewing gum, using tobacco or using the toilet.

■ Wash contaminated clothing before reuse; discard shoes if contaminated.

■ Do not consume food, drink or tobacco in areas where they may become contaminated.

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Effects of Overexposure/First AidResponse IngestionReactions may initially include nonspecific discomfort, such as nausea, vomiting,headache or weakness; temporary nervous system effects, such as muscular weakness, tremors and incoordination may also occur.

IF SWALLOWED: Call poison control center or doctor immediately for treatmentadvice. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person. If vomitingoccurs spontaneously, keep head below hips to prevent aspiration of liquid into thelungs. Aspiration of vomitus into the lungs must be avoided because even a smallamount may result in aspiration pneumonitis. Get medical attention.

InhalationMay result in difficulty breathing.

IF INHALED: Move person to fresh air. If person is not breathing, call 911 or anambulance, then give artificial respiration, preferably by mouth-to-mouth, if possible.Call a poison control center or doctor for further treatment advice.

Eye ContactReactions may initially include eye irritation with discomfort, tearing or blurring of vision.

IF IN EYES: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

Skin ContactReactions may initially include a transient (several minutes up to approximately 24 hours), persistent burning or prickling sensation, usually not accompanied byvisible irritation or rash.

IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediatelywith plenty of water for 15 to 20 minutes. Call a poison control center or doctor fortreatment advice.

Note to Physician — Wash with soap and water immediately. After drying, apply vitamin E cream or oil (12,000 international units of vitamin E per fluid ounce, available at drug stores and supermarkets). If vitamin E cream or oil is not available, liberally apply vegetable oil over any painful areas; the oil or cream may be used repeatedly until relief is achieved. Relief may come within minutes;symptoms usually disappear after several hours. Contains xylene range aromaticsolvent — vomiting may cause aspiration pneumonia.

Medical EmergenciesFor medical emergencies involving DuPont™ Asana® XL insecticide and related formulations of any other DuPont agrichemical product, call toll free: 1-800-441-3637.

This is a 24-hour DuPont product information and emergency response number in Wilmington, Del. Caller should state, “This is a medical emergency.”

The caller will be placed in contact with a poison control center. Caller should beprepared to state the name of the DuPont product involved and the attendingphysician’s name, address and phone number.

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Notes

Notes

Asana® XL, Lannate®, Vydate®, Ambush, Ammo, Aztec, Baythroid, Brigade, Capture, Cymbush, Decis, Discipline, Empower, Fury, Karate, Mustang, Mustang Max, Perm-UP, Pounce, ProAxis, Renounce, Silencer, Tempo, UP-Cyde, Warrior and Waylay are restricted-use pesticides.This reference guide is not intended as a substitute for the product label for the products referenced herein. Product labels for the referencedproducts contain important precautions, directions for use and product warranty and liability limitations that must be read before using theproduct. Applicators must be in possession of the product label at the time of application. Always read and follow all label directions and precautions for use.The DuPont Oval Logo, DuPont™, The miracles of science™, Asana®, Avaunt®, Lannate®, Steward® and Vydate® are trademarks or registeredtrademarks of DuPont or its affiliates.Ambush, Cymbush, Karate and Warrior are trademarks or registered trademarks of Syngenta Crop Protection. Ammo, Brigade, Capture, Fury, Mustang and Pounce are registered trademarks of FMC Corporation. Aztec, Baythroid, Decis, Renounce, Scout and Tempo are trademarks or registered trademarks of Bayer CropScience. Empower is a trademark of Helena Chemical Company. Discipline is aregistered trademark of AMVAC Chemical Corporation. ProAxis is a registered trademark of PytechChemicals Gmbh. Silencer is a trademark of Makhteshim Chemical Works LTD.Copyright © 2002-2006 E.I. du Pont de Nemours and Company. All Rights Reserved. 2/06Reorder No.: K-09355 (Replaces H-95335)