echo to guide percutaneous interventions · 2014-12-14 · echo to guide percutaneous interventions...
TRANSCRIPT
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Echo to Guide Percutaneous
Interventions
Richard A. Grimm, DO, FACC, FASE
Director, Echocardiography
Department of Cardiovascular Medicine
Heart & Vascular Institute
Cleveland Clinic
Cleveland, Ohio, USA
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Echocardiography in Guiding Percutaneous
Interventions
•Myxomatous mitral valve disease
•Aortic valve disease
•Per-valvular regurgitation
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Cribier-Edwards
Percutaneous Heart Valve SYSTEM
24 Fr sheath
FlexCath Crimper
Valve
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Transcatheter Heart Valve
• Balloon expendable
• Stainless steel stent
• Bovine (equine) pericardium
• Optimal hemodynamics
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RCA LM
Patent Coronary Arteries
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Left main ostium Left main ostium
Left cusp
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Patient #1 R.M.
90 yo Man
• 90 year-old male
• Severe aortic stenosis with NYHA Class III symptoms
• Past Medical History:
–Coronary Artery Disease with CABGx4 in 1998
–Right Carotid Endarterectomy
–Atrial fibrillation
–Hypertension
–Marked Thoracic Kyphosis
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Echocardiography
21 mm
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Echocardiogram
• LVEF 50%
• Stage II Diastolic Dysfunction
• Mild left ventricular hypertrophy
• Severe Aortic Stenosis (57/33 mmHg) valve
area 0.7cm2. 1-2+ AI.
• 1-2+ Mitral Regurgitation
• RVSP 69mm Hg
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Balloon Valvuloplasty
Used to Predilate the Valve
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Valve Deployment
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Result
Patient is playing golf 1 year later!
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3D TEE in guiding PAVR
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Placing device relative to valve during PAV
Live 3D Guidance of PAVR
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Rapid pacing balloon inflation of bioprosthesis
Live 3D Guidance of PAVR
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Leaflet motion after PAVR
Post-Deployment Assessment
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1+ AR, Δp = 12/8 mmHg 2-3+ AR, Δp = 54/38 mmHg
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Symptomatic Severe Aortic Stenosis
ASSESSMENT: High Risk AVR Candidate
3105 Total Patients Screened
PARTNER Study Design
High Risk TA
ASSESSMENT:
Transfemoral Access
TAVI
Trans
femoral
Surgical
AVR
High Risk TF
Primary Endpoint: All Cause Mortality (1 yr)
(Non-inferiority)
TAVI
Trans
femoral
Surgical
AVR
1:1 Randomization 1:1 Randomization
VS VS
Standard
Therapy
(usually BAV)
ASSESSMENT:
Transfemoral Access
Not In Study
TAVI
Trans
femoral
Primary Endpoint: All Cause Mortality over length of
trial (Superiority)
1:1 Randomization
VS
Total = 1058 patients
2 Parallel Trials:
Individually Powered High Risk n= 700 Inoperable n=358
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Primary Endpoint
• All-cause mortality over the duration of the study
• Hierarchical composite of all-cause mortality and repeat
hospitalization over the duration of the study
Co-Primary Endpoint
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Procedural Outcomes TAVI (179 patients)
• 6 (3.4%) pts did not receive TAVI
2 died before scheduled implant
2 unsuccessful transfemoral access
2 intra-procedural annulus measurement too large and procedure
aborted
• After randomization, median time to TAVI was 6 days (inter-
quartile range 3 - 11 days)
• During TAVI (first 24 hours)
2 (1.1%) deaths
3 (1.7%) major strokes
1 (0.6%) valve embolization
2 (1.1%) pts with multiple (≥ 2) valve implants
• In the first 30 days, 11 (6.4%) pts receiving TAVI died
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All Cause Mortality
0 6 12 18 24
Numbers at Risk
TAVI 179 138 122 67 26
Standard Rx 179 121 83 41 12
∆ at 1 yr = 20.0%
NNT = 5.0 pts
Standard Rx
TAVI
All-
cause m
ort
alit
y
(%)
Months
0
20
40
60
80
100
50.7%
30.7% HR [95% CI] =
0.54 [0.38, 0.78]
P (log rank) < 0.0001
46% RR reduction in mortality
63% RR reduction in CV mortality
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0 6 12 18 24
Standard Rx
TAVI
All-
cause m
ort
alit
y o
r
Repeat
Hospitaliz
ation
(%)
Months
0
20
40
60
80
100
Numbers at Risk
TAVI 179 117 102 56 22
Standard Rx 179 121 49 23 4
∆ at 1 yr = 29.1%
NNT = 3.4 pts
71.6%
42.5%
Mortality or Repeat Hosp
HR [95% CI] =
0.46 [0.35, 0.59]
P (log rank) < 0.0001
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AV
A (
cm
2)
1.5
1.0
0.5
0
2.0
2.5
Baseline
N=163
30 Day
N=143
6 Months
N=100
1 Year
N=89
Me
an
Gra
die
nt
(mm
Hg
)
50
40
30
20
60
70
10
0
Error bars = ± 1 Std Dev
AVA and Mean Gradients All TAVI patients
0.64
1.53
1.61
1.57
12.1 11.3 10.8
44.6
P < 0.0001
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Clinical Outcomes at 30 Days and 1 Year
Major Stroke
P = 0.06 P = 0.18
6.7
10.6
1.7 4.5
30 Days 1 Year
All Stroke or TIA
P = 0.03 P = 0.04
TAVI (n=179) Standard Rx (n=179)
per
cent
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0 6 12 18 24
Mortality or Major Stroke
Standard Rx
TAVI
All-
cause m
ort
alit
y o
r
Majo
r S
troke (
%)
Months
0
20
40
60
80
100
Numbers at Risk
TAVI 179 132 118 56 25
Standard Rx 179 118 83 41 12
∆ at 1 yr = 18.3%
NNT = 5.5 pts
51.3%
33.0% HR [95% CI] =
0.58 [0.43, 0.78]
P (log rank) = 0.0003
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Conclusions
In patients with severe AS and symptoms, who are not
suitable candidates for surgery…
• TAVI was accomplished with acceptable safety
• TAVI markedly reduced the rate of…
all-cause mortality by 46%
all-cause mortality & hospitalization by 54%,
• TAVI improved cardiac symptoms
• TAVI resulted in more frequent complications
major vascular complications
major bleeding episodes
major strokes
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Clinical Implications
• Balloon-expandable TAVI should be the new standard of
care for patients with aortic stenosis who are not suitable
candidates for surgery!
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Echo to Guide Clinical Management in
Patients with Mitral Regurgitation
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Morphology
Rheumatic Myxomatous
LV Normal/Small Dilated
MV Thick/restricted
Thick/hypermobile
Chordae Short Long
AV involved Often Rare
Ca++ +++ +
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Courtesy Dr. J. Veinot
Myxomatous Mitral Valve Disease
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Quantitation of Mitral Regurgitation by Echo
• Color jet area
• PISA
• Vena contracta
• Volumetric Assessment
• Jet density by CW Doppler
• Chamber Size
• Pulmonary veins
Regurgitant Orifice Area > 0.4 cm2 = Severe
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Proximal Flow Convergence Method
r
0
-42
42 cm/s
Q = 2pr2v
ROA = Q/v0
Flow: Q
Orifice vel: v0
Aliasing velocity: v (= 42 cm/s)
Aliasing radius: r
Flow thru any isovelocity shell is equal to instantaneous orifice flow
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Indications for Transthoracic Echocardiography
CLASS I
• 1. TTE is indicated for baseline evaluation of LV size and function. RV and left atrial size, pulmonary artery pressure and severity of MR (Table 4) in any patient suspected of having MR, (Level of Evidence: C)
• 2. TTE is indicated for delineation of the mechanism of MR. (Level of Evidence: B).
• 3. TTE is indicated for annual or semiannual surveillance of LV function (estimated by ejection fraction and end-systolic dimension) in asymptomatic patients with moderate to severe MR. (Level of Evidence: C)
• 4. TTE is indicated in patients with MR to evaluate the MV apparatus and LV function after a change in signs or symptoms. (Level of Evidence: C)
• 5. TTE is indicated to evaluate LV size and function and MV hemodynamics in the initial evaluation after MVR or MV repair. (Level of Evidence: C)
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INDICATIONS FOR TEE
CLASS I
• 1. Preoperative or intraoperative TEE is indicated to establish the
anatomic basis for severe MR in patients in whom surgery is
recommended to assess feasibility of repair and to guide repair
(Level of Evidence: B)
• 2. TEE is indicated for evaluation of MR patients in whom TTE
provides non-diagnostic information regarding severity of MR,
mechanism of MR and/or status of LV function. (Level of Evidence
B)
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TTE apical LAX
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TTE
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Mechanisms of MR
This echo evaluation shows ?
a. Anterior lealfet prolapse due to myxomatous valve
disease
b. Restriction of posterior leaflet due to RHD
c. Restriction of posterior leaflet due to RCA scar
d. Bileaflet prolapse with anterior prolapse > posterior
prolapse?
e. Restriction of posterior leaflet due to anorexigen
induced valvular disease
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Pre Intraoperative TEE
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Mechanisms of Mitral Regurgitation
• Excessive Leaflet Motion
– Prolapse
– Leaflet, chordal, or papillary muscle disruption
• Normal Leaflet Motion
– Perforation
• Restricted Leaflet Motion
– Rheumatic
– Ischemic
– Anorexigen Inducd
– Mitral annular calcification
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Feasibility of Repair - by MR mechanism Stewart WJ: Intraoperative Echocardiography. Chap 54 in Topol’s Cardiology Textbook
0
20
40
60
80
100
EXC
ALL
EXC
post
EXC
ant
EXC
both RES
NORM
DCM TOTAL
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Papillary Muscle Dysfunction
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Repair or Replace?
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Repair or Replace?
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Repair or Replace
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Repair or Replace?
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Repair or Replace?
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What is the Pathology?
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Mechanism?
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Stress Echo
Rest Stress
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LVOT Gradients
Rest Stress
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Repair or Replace?
Rest Stress
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Bonow, R. O. et al. J Am Coll Cardiol 2008;52:e1-e142
Management of Patients With Chronic Severe MR
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Timing of Surgery: LV Function
Enriquez-Sarano Circulation 1994; 90: 830-837
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Frequency of Echo Follow-up for Mitral Regurgitation
MR Severity LV Function Frequency
Mild Normal ESD & EF Q 5 yr
Moderate Normal ESD & EF Q 1-2 yr
Moderate ESD >40 mm
or EF < 65%
Q1 yr
Severe Normal ESD & EF Q 1yr
Severe ESD > 40 mm
or EF < 65%
Q 6 mo
Catherine Otto NEJM 2005