editorial biomarker and translational prostate ... - hindawi

Editorial Biomarker and Translational Prostate Cancer Research Andreas Doll, 1 Jeremy Clark, 2 and Colleen Nelson 3 1 Biomedical and Translational Oncology Research Unit, Institut de Recerca Vall d’Hebron, Edifici Collserola, Passeig de la Vall d’Hebron, 119-129 Barcelona, Spain 2 Cancer Genetics, University of East Anglia, Norwich, Norfolk NR4 s7TJ, UK 3 Australian Prostate Cancer Research Centre, Brisbane, QLD 4102, Australia Correspondence should be addressed to Andreas Doll; [email protected] Received 17 November 2014; Accepted 17 November 2014 Copyright © 2015 Andreas Doll et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. e existing clinical biomarkers for prostate cancer (PCa) are not ideal, since they cannot specifically differentiate between those patients who should be treated immediately and those who should avoid overtreatment. Current screening tech- niques lack specificity, and a decisive diagnosis of PCa is based on prostate biopsy. Although PCa screening is widely utilized nowadays, two-thirds of the biopsies performed are still unnecessary. us, the discovery of noninvasive PCa biomarkers remains an urgent unmet medical need. Once metastasized, there is still no curative therapy. A better understanding of sustained androgen receptor signalling in castration resistant prostate cancer (CRPC) has now led to the development of more effective therapies. We need a better understanding of the molecular and cellular aspects of prostate carcinogenesis and progression. Identification of cancer initiating cells and therapies against these populations is a promising way forward to fight this disease. Acknowledgments e editors thank the authors for their efforts and time spent for each manuscript. e lead editor would like to thank all editors for the time spent in reviewing, assigning reviews, and commenting on submitted manuscripts. e editors hope that this special issue will prove useful to investigators, policy makers, and veterinarians involved in the study of respiratory diseases of small ruminants. At last but not least, the expertise and cooperation of editorial team are highly acknowledged. Andreas Doll Jeremy Clark Colleen Nelson Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 309851, 1 page http://dx.doi.org/10.1155/2015/309851

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Page 1: Editorial Biomarker and Translational Prostate ... - Hindawi

EditorialBiomarker and Translational Prostate Cancer Research

Andreas Doll,1 Jeremy Clark,2 and Colleen Nelson3

1Biomedical and Translational Oncology Research Unit, Institut de Recerca Vall d’Hebron, Edifici Collserola,Passeig de la Vall d’Hebron, 119-129 Barcelona, Spain2Cancer Genetics, University of East Anglia, Norwich, Norfolk NR4 s7TJ, UK3Australian Prostate Cancer Research Centre, Brisbane, QLD 4102, Australia

Correspondence should be addressed to Andreas Doll; [email protected]

Received 17 November 2014; Accepted 17 November 2014

Copyright © 2015 Andreas Doll et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The existing clinical biomarkers for prostate cancer (PCa) arenot ideal, since they cannot specifically differentiate betweenthose patients who should be treated immediately and thosewho should avoid overtreatment. Current screening tech-niques lack specificity, and a decisive diagnosis of PCa isbased on prostate biopsy. Although PCa screening is widelyutilized nowadays, two-thirds of the biopsies performed arestill unnecessary. Thus, the discovery of noninvasive PCabiomarkers remains an urgent unmet medical need. Oncemetastasized, there is still no curative therapy. A betterunderstanding of sustained androgen receptor signalling incastration resistant prostate cancer (CRPC) has now led tothe development of more effective therapies. We need abetter understanding of the molecular and cellular aspectsof prostate carcinogenesis and progression. Identification ofcancer initiating cells and therapies against these populationsis a promising way forward to fight this disease.

Acknowledgments

The editors thank the authors for their efforts and time spentfor each manuscript. The lead editor would like to thank alleditors for the time spent in reviewing, assigning reviews,and commenting on submittedmanuscripts.The editors hopethat this special issue will prove useful to investigators, policymakers, and veterinarians involved in the study of respiratorydiseases of small ruminants. At last but not least, the expertiseand cooperation of editorial team are highly acknowledged.

Andreas DollJeremy Clark

Colleen Nelson

Hindawi Publishing CorporationBioMed Research InternationalVolume 2015, Article ID 309851, 1 pagehttp://dx.doi.org/10.1155/2015/309851