effect of ivermectin on anopheles aquasalis, a malaria vector from south america marcus lacerda md,...
TRANSCRIPT
Effect of ivermectin onAnopheles aquasalis, a malaria vector
from South America
Marcus Lacerda MD, PhDFundação de Medicina Tropical Dr. Heitor Vieira Dourado
Instituto Leônidas & Maria Deane (FIOCRUZ-AM)
Effect on survival-6 volunteers (3 male and 3 female)-Blood sample (5mL)-100 mosquitos/sample/time-Observation at 24 hours intervals-Dead mosquitos removed and counted
METHODSPatient diagnosed with
helminthiasis with ivermectin indication
D0 D2 D4 D7
- IC signature- New sample after 4h
- Patient returns for new samples
D14
Analysis including all the 6 volunteers samples (males and females)
P < 0.001
RESULTS
14 days post-ingestion effect
- LC50 calculation- Evaluate the effect on the flight capacity- Evaluate the effect on the reproductive capacity- Evaluate the effect on the mosquito infection (P. vivax)- Verify the in vitro effect on P. vivax- Verify the mosquito gene expression profile under
ivermectin effect- Perform the same studies with Anopheles darlingi (from
the field), the major vector in South America- Evaluate ivermectin to massive drug administration
(MDA) trials under discussion in the Brazilian Amazon
FUTURE PERSPECTIVES