effect of vitamin a on severity of acute.pptx

8/11/2019 Effect of vitamin A on severity of acute.pptx

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JOURNALREADING

EFFECTOFVITAMINA ON

SEVERITYOFACUTEDIARRHEAIN

CHILDRENMarlisye Marpaung, Supriatmo, Atan Baas Sinuhaji

Paediatrica Indonesiana, Vol. 53, No. 3, May 2013

Eggi Erlangga

1015061

Preceptor:dr. H. Tisna Sukarna, Sp.A., MBA, M.KOM


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BACKGROUND

In Indonesia, diarrhea remains a major cause of

death in infant and children.

In the GI tract, vitamin A deficiency is both a cause

and a consequence of diarrheal disease.

Many studies have been conducted on the effect of

vitamin A on acute diarrheal management, but the

outcomes remain inconclusive.


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OBJECTIVE

To determine the effectiveness of vitamin A in

reducing the severity of acute diarrhea in children.


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METHOD

Randomized controlled trial in the Secanggang District,Langkat, North Sumatra.

August 2009-January 2010

Children aged 6 months to 5 years with acute diarrhea.

Exclusion: severe dehydration, cholera, severemalnutrition, encephalitis, meningitis, sepsis,bronchopneumonia, TBC, vitamin A consumer in 4months.

Subjects were randomized into two groups.

Given single dose of vitamin A in group 1, with doses of100.000 IU for subjects aged 6-11 months or with bodyweights 12months or > 10 kg


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Group 2 was given placebo.

All subjects were monitored every 3 days until

recovery.

Recovery from diarrhea was defined as a frequencyof defecation less than 3 times a day, loose or soft

stool consistency becoming normal, and stool

volume becoming normal (less than 200 mL per

day)


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RESULTS


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DISCUSSION

These results support previous findings about lower

concentration of vitamin A in children with diarrhea

that its supplementation may reduce the risk of

diarrhea.

Diarrhea disease may cause VAD by several

mechanisms. First, steatorrhea can lead to a

generalized loss of fat-soluble vitamins. Second,

damage to the brush border may inhibit the function

of brush border retinyl esterases, which contributesto the intestinal absorption of vitamin A.


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A deficiency adversely affects the epithelial lining,

leading to decreased mucous secretion and

weakened local barriers to infection.

Vitamin A deficiency may also lead to goblet cell

depletion, abnormal villous architecture and villous

atrophy, as well as adversely affecting humoral and

cellular immune functions.


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CONCLUSION

Vitamin A supplementation is effective in reducing

the severity of acute diarrhea in children under five

years of age.


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THANKYOU

effect of vitamin a on severity of acute.pptx

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