electrical signals within the nervous system ( lec 2)
DESCRIPTION
Electrical Signals within the Nervous System ( lec 2). Electrical Signals within the NS. 1-Action potential 2-Electrotonic(graded) potential. Fig. 12.13. Myelination increase membrane resistance & decrease membrane capacitance . . Classification for Peripheral Fibers. - PowerPoint PPT PresentationTRANSCRIPT
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Electrical Signals within the Nervous System (lec 2)
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Electrical Signals within the NS
1-Action potential2-Electrotonic(graded) potential
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Fig. 12.13
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Myelination increase membrane resistance & decrease membrane capacitance.
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Classification for Peripheral Fibers
Nolte 9-21
Major afferent
Major efferent
Fiber size: I, II, III, IVConduction velocity: A, B, C
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Susceptibility of Different Types of Fibers toConduction Block by Various Agents
Most susceptible Effect Least susceptible
Block by hypoxia B A C
Block by pressure A B C
Block by local anesthetics
C B A
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Absolute & Relative Refractory Period
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Refractory period
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Action potential• Regenerative,• Threshold• Move along axon• Voltage gated channels• Propagates• All or None • Amplitude above 100 mv• Short duration• Depolarizing then repolarizing• Refractory period• No summation.• Function: carries information faithfully unchanged from one end of neuron to
other, without decrement.
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Convulsion/Fit/Seizure
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Effect of ionic composition on nerve fiber excitability:
Hypercalcaemia & HypokalemiaDecrease n.f. excitability.
Hypocalcaemia increase n.f. excitability