electroceuticals industry landscape€¦ · pharma market is huge!! chronic pain treatment market...
TRANSCRIPT
![Page 1: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/1.jpg)
Electroceuticals Industry Landscape
This work was created in an open classroom environment as part of a program within the Sutardja Center for Entrepreneurship & Technology and led by Prof. Ikhlaq Sidhu at UC Berkeley. There should be no proprietary information contained in this paper. No information contained in this paper is intended to affect or influence public relations with any firm affiliated with any of the authors. The views represented are those of the authors alone and do not reflect those of the University of California Berkeley.
Rajesh Ramanujam, Saurabh Chopra, Rainer Unterguggenberger, Xumin Wu
![Page 2: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/2.jpg)
Electroceuticals
● Medical Devices
● Read and modify electrical signals passing along nerves
● Offer treatment for a wide variety of health conditions
![Page 3: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/3.jpg)
Pharma Market is Huge!!
Chronic pain treatment market is expected to reach $105.9 billion by 2024PRNewswire, Feb2019
Global Rheumatoid Arthritis Drugs Market $50.5 Billion by 2025iHealthCareAnalyst, Nov2019 Global Allergy Drugs Market $4.8
Billion by 2023MarketResearchFuture, Mar2020
![Page 4: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/4.jpg)
Nevro: Managing Chronic Back Pain
● Back pain is No.1 cause of disability around the world.
● Costs U.S. economy > $100 billion
● Electrical pulses to spinal cord achieve a significant reduction in severe back and leg pain
● Alternative to Painkillers (Opioids)
www.nevro.com
![Page 5: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/5.jpg)
Setpoint Medical: Chronic Inflammation
● Pacemaker for Brain
● Chronic Inflammation Management
● Unlock Restorative Power of Inflammatory reflex
● Intersecting & manipulating signaling from the Brain through Vagus nerve
www.setpointmedical.com
![Page 6: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/6.jpg)
Explosive Growth of Electroceuticals
Min-Invasive
Source: BBC Publishing, 2019Source: Grandviewresearch, 2019
30-40B$ Expected Market in FY24-25Double digits CAGR
Invasive
![Page 7: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/7.jpg)
StimWave
LivaNova
Invasive & Min-Invasive Electroceuticals
Nevro
Bioelectronics
Setpoint
Cala HealthElectroCoreLivaNova
Medtronic
Cochlear
Sonova
Several minimally invasive products popping up
![Page 8: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/8.jpg)
Market Breakdown: Segments (<2010)
Traditional Pharma
Electroceuticals Both
![Page 9: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/9.jpg)
Market Breakdown: Segments (2020)
More Big-Pharma companies investing in Electroceuticals
Traditional Pharma
Electroceuticals Both
![Page 10: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/10.jpg)
Market Breakdown: Geography
SonovaElectroCore
Setpoint Med.
Medtronic
Stimwave
Nevro
Cala Health
Cochlear
GalvaniLivaNova
Bioelectronics
Companies specializing in Electroceuticals springing up across the world
![Page 11: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/11.jpg)
Electroceuticals Ecosystem
DataDevices
Data Analytics
FDA & Regulation
PatientDoctors
Surgeons
● All six parts of ecosystem interdependent
● More complex systems require advances in all areas
![Page 12: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/12.jpg)
Challenges
- Complexity
- 86 Billion neurons
- 150 Trillion Synapses
![Page 13: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/13.jpg)
Challenges
- Complexity
- Safety- Infection(1.5~2%)
- Reliability
- Interference
![Page 14: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/14.jpg)
Challenges
- Complexity
- Safety
- Regulations
- A central registry
- Ethics
NIH ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397644/
![Page 15: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/15.jpg)
Electroceuticals Industry SWOT AnalysisStrengths• Medical breakthroughs & Semiconductor
advancements:- Mapping Neural response, Miniaturization, Low power connectivity
• Strong VC, Funding interests in Health care
Opportunities• Ready to take on >100B pharmaceutical industry
• Patient compliance, improved quality of care
• Big Data/ML:- Improved response, patient care
Threats• Regulatory Compliance
• Security, Privacy concerns
• Business model scalability
Weakness• Long term efficacy, Patient acceptance
• Surgical intervention creating barriers
• Diverse ecosystem players with conflicting business models
![Page 16: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/16.jpg)
Pre 2010: Challenge is Selectivity of Stimulus “The best way to predict the future is to study the past”● Electroceuticals approved for seizures,
depression, Obesity, pain management ● Problem is selectivity:
○ Side effects from non-selective stimulation, limits treatment option to only ⅓ of patients
● Future: Miniaturization enables Closed-Loop Control
○ Controlled stimulation by recording whole organ function
● Big data/ML to continuously improve selectivity ○ Huge advantage over pharmaceutical options with little side
effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586833
![Page 17: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/17.jpg)
Future Landscape Predictions● Electroceuticals will be mainstay treatment for Chronic disease management
taking on pharma industry due to recent technology breakthroughs.
● Next big wave of advances/products will come post changes in regulation and
public policy
● Players with strengths on multiple ecosystem components & established
business scale through partnerships will win.
○ GSK/Galvani, Verily/Google is primed to lead this industry
○ Pharmaceutical industry majors (eg: Pfizer, J&J) will acquire/partner with
electroceuticals startups
![Page 18: Electroceuticals Industry Landscape€¦ · Pharma Market is Huge!! Chronic pain treatment market is expected to reach $105.9 billion by 2024 PRNewswire, Feb2019 Global Rheumatoid](https://reader035.vdocument.in/reader035/viewer/2022070108/6038ec279b7de636c6235152/html5/thumbnails/18.jpg)