electrophysiological assessment of neuromuscular transmission
DESCRIPTION
The Presentation discusses the detailed aspects of the Electrophysiological Aspects of Neuromuscular transmission, as well as the diagnostic features of the various types of NMJ Disorders.TRANSCRIPT
Acetyl co A +Choline
Cholineacetylase
Ach synthesis
Main store
Mobilization pool
Immediately available pool
Depolarisation->EPP->MAP
ACh->Acetic acid+choline
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Myasthenia GravisRepetitive Nerve Stimulation
baseline
Post exercise
2 minutes
3 minutes
Repeat exercise
Single Fiber EMGMyasthenia Gravis
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Ca2+ channel structure
2
1
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
Synapticcleft
Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft.
The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell.
An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh.
Appearance of an action potential in the sarcolemma
ACh binding at the motor and plateRelease of acetylcholine
Arrival of an action potential at the synaptic terminal
Sarcolemma ofmotor end plate
Arriving action potential
Vesicles
ACh
AChE molecules
AChreceptorsite
Action potential
Synaptic terminal
Axon
Sarcolemma
Musclefiber
Actionpotential
Na+
Na+
Na+
SCS
Choline acetyl transferase deficiency
20 Hz
Summary
