emf biological effects: proposed mechanisms fileoxidation and antioxidant depletion ... static...

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EMF and Biological Effects: Proposed Mechanisms EFFECTS ON MOLECULAR BONDS EFFECTS IN GENE FUNCTION AND STRUCTURE EFFECTS ON SPECIFIC SUBCELLULAR ELEMENTS EFFECTS AT LEVEL OF MEMBRANE GROUP CELL BEHAVIOR ELECTRICAL EFFECTS ON CELLS, SYNAPSES PULSED, MAGNETIC EFFECTS ON CELLS, SYNAPSES EFFECTS ON PROTEINS, HORMONES, NEUROTRANSMITTERS SPECIES EFFECTS, TROPHIC CASCADE EFFECTS, LOSS OF BIODIVERSITY "N o kno wn mec hanism" -- "So What?" Indir ect Effect : Med. De vice int er fer ence BREAKAGE, OXIDATION NOS, oxi . stress Oxidative stress , RF Oxidative DNA damage ELF-MF , oxidative stress, cell death LIVING ANTENNAS, ARTIFICIAL EMF GENETIC FUNCTIONAL CHANGES, DAMAGE FREE RADICAL DAMAGE, NUTRIENT DEPLETION DNA as a fractal antenna HAARP interference with bee homing Altered gene expression Sperm damage : structural, functional Oxidation and antioxidant depletion Osmolarity af fects threshold EF ef fects T riage nutrients diverted, stress response MAGNETIC FIELD EFFECT ON MAGNETITE ELECTRO-MECHANICAL TRANSDUCTION BY CALCITE EMF, INTERFACIAL WATER CHANGES TO CRYPTOCHROME MOLECULE ATP FORMATION AND MAGNETIC SPIN HOT "NANO SPOTS" ELF , m agnetite in human tissues Cell death, ferromagnetic transduction Pineal calcite sensitive to MW/RF Overview: Ramazzini Institute Mae-W an Ho , coherent domains Susak: EMF , soliton , water struct ure Cell hydration as EMF biomarker for bio-ef fects Cryptochromes EMF Cryptochrome mediates magnetosensitivity Heroux Unified Theory , MF and A TP Hot " Nano spots" in heterogeneous tissues BLOOD FLOW, VESSEL DAMAGE STATIC MAGNETIC FIELD PLUS EMF PUSHING MOLECULES CALCIUM EFFLUX, MEMBRANE/RECEPTOR EFFECTS INTRODUCTION OF "NOISE" Disrupted cerebral blood flow Albumin leakage, barrier breech Induction of cyclotron resonance Calcium ion, cyclotron resonance, MF Electroporation RF , receptor clustering Rouleau formation , MW Ion channel transduction Membrane nanopore formation EM Biocompatibility: Compensatory Magnetic Oscillation Induction of stochastic resonance Stochastic resonance, voltage-gated channels, EMF THERMOELASTIC WAVE EFFECT ORGAN AND TISSUE FUNCTION INTERFERENCE WITH NEURONAL OSCILLATIONS CIRCADIAN EFFECTS Microwave auditory ef fect Thermoelastic theory , MW MW , heart rate variability Decrease in band coherence Appearance of EEG slow waves More anterior alpha, less posterior Neuronal network firing/burst rate changes Chrononodisruptive ef fects Disrupted EM interaction between organisms, environment INDUCED E CURRENTS, INCREASED BODY VOLTAGE CHANGES IN POLARIZATION, SYNAPSES DENSITY OF PHOTONS EFFECT Body voltage information Induced electric currents , A.L.S. T ransients, BV , altered gradients, gap junctions Electrical fields, polarization of neurons Polarization, dif ference natural/unnatural V oltage gated calcium channels sensitive V oltage transients interfere with gap junctions EM uncoupling of signal transduction in water Gap junction altered, melatonin , tumor promotion High photon density, dielectric ef fect of MW Bioelectric phenomena and photon aggregation EFFECT ON NON-EXCITABLE CELLS PEMF mechanisms Mitotic spindle disruption , nonlinear , AM ALTERATION OF MATRIX DEFICIENCY OF NATURAL EMF HEAT SHOCK PROTEINS DENATURATION OF PROTEINS Melatonin hypothesis ELF , Increased beta-amyloid Alteration of blood parameters Increased production, release, histamine Change in enzyme kinetics , catalyzed reactions Digital stress,global EM toxicity Cancer , mitochondria , altered natural field Stress protein synthesis Hsp70 , mobile phone stress marker EMF and the folding of protein ELF-MF , protein proton relaxation EFFECTS ON BEES, POLLINATORS EFFECTS ON TREES, OTHER PLANTS Barrie T rower , Bees, 2010 Massive destruction of nature by EMF EMF and T ree Damage RF , tomato plants, stress mRNA ELF , pea roots, calcium disruption HOW DO ARTIFICIAL NON-IONIZING ELECTROMAGNETIC FIELDS INTERFERE WITH BIOLOGICAL TISSUE FUNCTIONS AND STRUCTURES? MANY MECHANISMS HAVE BEEN PROPOSED. THEY ARE NOT EXCLUSIVE OF EACH OTHER. THEY ARE NOT EQUALLY WELL STUDIED OR SUPPORTED. SOME OF THE EFFECTS ARE MORE UPSTREAM PHYSIOLOGICALLY, AND THEREFORE CAUSE OTHERS. THE EFFECTS ON ANY GIVEN INDIVIDUAL DEPEND UPON THE TYPE OF EXPOSURE AS WELL AS THE SPECIES, GENDER, HEALTH, AGE OR TISSUE(S) INVOLVED. MECHANISMS DIFFER FROM SIGNS OF PATHOLOGY OR SYMPTOMS OF ILLNESS; RATHER, THEY EXPLAIN HOW SIGNS AND SYMPTOMS ARE INITIATED. Home: Oscillatorium Newest version this map Date of this update: 05-19-16 CELLULAR FUNCTIONS AND BEHAVIORS Orientation of magnetite "Switching" of cryptochrome molecule Enzyme functions, methionine synthase Gene expression, stress proteins, apoptosis Clumping of some cells, movements of others CELLULAR STRUCTURES Molecular bonds of DNA, RNA Alterations in ATP production, different mechanisms Membranes, cellular, subcellular Resonance changes within fluid compartments Receptors/channels within membranes Concentrations of ions, molecules, nutrients TISSUE EFFECTS Decreased integrity of blood-brain barrier Brain dysfunction: brainwaves, sensory disturbance Brain developmental issues: autism Brain structural changes, beta-amyloid, tumors Brain function, cognitive effects, abnormal proteins Circadian changes in hormonal releases Cardiovascular rhythm changes Immune response alterations CASCADING MECHANISMS MOLECULAR TO MULTI-SPECIES Free radical cascades Calcium influx and cellular activity Field reorientation of ions, cells Single species gene pool disruptions Multi-species trophic cascade

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Page 1: EMF Biological Effects: Proposed Mechanisms fileOxidation and antioxidant depletion ... STATIC MAGNETIC FIELD PLUS EMF PUSHING MOLECULES ... RF, tomato plants, stress mRNA

EMFand

Biological Effects:Proposed Mechanisms

EFFECTS ON MOLECULAR BONDS

EFFECTS IN GENE FUNCTION AND STRUCTURE

EFFECTS ON SPECIFIC SUBCELLULAR ELEMENTS

EFFECTS AT LEVEL OF MEMBRANE

GROUP CELL BEHAVIOR

ELECTRICAL EFFECTS ON CELLS, SYNAPSES

PULSED, MAGNETIC EFFECTS ON CELLS, SYNAPSES

EFFECTS ON PROTEINS, HORMONES, NEUROTRANSMITTERS

SPECIES EFFECTS, TROPHIC CASCADE EFFECTS, LOSS OF BIODIVERSITY

"No known mechanism" -- "So What?"

Indirect Effect:Med. Device interference

BREAKAGE, OXIDATION NOS, oxi. stress

Oxidative stress, RF

Oxidative DNA damage

ELF-MF, oxidative stress, cell death

LIVING ANTENNAS, ARTIFICIAL EMF

GENETIC FUNCTIONALCHANGES, DAMAGE

FREE RADICAL DAMAGE, NUTRIENT DEPLETION

DNA as a fractal antenna

HAARP interference with bee homing

Altered gene expression

Sperm damage: structural, functional

Oxidation and antioxidant depletion

Osmolarity affects threshold EF effects

Triage nutrients diverted, stress responseMAGNETIC FIELD EFFECT ON MAGNETITE

ELECTRO-MECHANICALTRANSDUCTION BY CALCITE

EMF, INTERFACIAL WATER

CHANGES TO CRYPTOCHROME MOLECULE

ATP FORMATION AND MAGNETIC SPIN

HOT "NANO SPOTS"

ELF, magnetite in human tissues

Cell death, ferromagnetic transduction

Pineal calcite sensitive to MW/RF

Overview: Ramazzini Institute

Mae-Wan Ho, coherent domains

Susak: EMF, soliton, water structure

Cell hydration as EMF biomarker for bio-effects

Cryptochromes EMF

Cryptochrome mediates magnetosensitivity

Heroux Unified Theory, MF and ATP

Hot "Nano spots" in heterogeneous tissues

BLOOD FLOW, VESSEL DAMAGE

STATIC MAGNETIC FIELDPLUS EMF PUSHING MOLECULES

CALCIUM EFFLUX,MEMBRANE/RECEPTOR EFFECTS

INTRODUCTION OF "NOISE"

Disrupted cerebral blood flow

Albumin leakage, barrier breech

Induction of cyclotron resonance

Calcium ion, cyclotron resonance, MF

Electroporation

RF, receptor clustering

Rouleau formation, MW

Ion channel transduction

Membrane nanopore formation

EM Biocompatibility: Compensatory Magnetic Oscillation

Induction of stochastic resonance

Stochastic resonance, voltage-gated channels, EMF

THERMOELASTIC WAVE EFFECT

ORGAN AND TISSUE FUNCTION

INTERFERENCE WITH NEURONAL OSCILLATIONS

CIRCADIAN EFFECTS

Microwave auditory effect

Thermoelastic theory, MW

MW, heart rate variability

Decrease in band coherence

Appearance of EEG slow waves

More anterior alpha, less posterior

Neuronal network firing/burst rate changes

Chrononodisruptive effects

Disrupted EM interaction between organisms, environment

INDUCED E CURRENTS,INCREASED BODY VOLTAGE

CHANGES INPOLARIZATION, SYNAPSES

DENSITY OF PHOTONS EFFECT

Body voltage information

Induced electric currents, A.L.S.

Transients, BV, altered gradients, gap junctions

Electrical fields, polarization of neurons

Polarization, difference natural/unnatural

Voltage gated calcium channels sensitive

Voltage transients interfere with gap junctions

EM uncoupling of signal transduction in water

Gap junction altered, melatonin, tumor promotion

High photon density, dielectric effect of MW

Bioelectric phenomena and photon aggregation

EFFECT ON NON-EXCITABLE CELLSPEMF mechanisms

Mitotic spindle disruption, nonlinear, AM

ALTERATION OF MATRIX

DEFICIENCY OF NATURAL EMF

HEAT SHOCK PROTEINS

DENATURATION OF PROTEINS

Melatonin hypothesis

ELF, Increased beta-amyloid

Alteration of blood parameters

Increased production, release, histamine

Change in enzyme kinetics, catalyzed reactions

Digital stress,global EM toxicity

Cancer, mitochondria, altered natural field

Stress protein synthesis

Hsp70, mobile phone stress marker

EMF and the folding of protein

ELF-MF, protein proton relaxation EFFECTS ON BEES, POLLINATORS

EFFECTS ON TREES, OTHER PLANTS

Barrie Trower, Bees, 2010

Massive destruction of nature by EMF

EMF and Tree Damage

RF, tomato plants, stress mRNA

ELF, pea roots, calcium disruption

HOW DO ARTIFICIAL NON-IONIZING ELECTROMAGNETIC FIELDS INTERFERE WITH BIOLOGICAL TISSUE FUNCTIONS AND STRUCTURES? MANY MECHANISMS HAVE BEEN PROPOSED. THEY ARE NOT EXCLUSIVE OF EACH OTHER. THEY ARE NOT EQUALLY WELL STUDIED OR SUPPORTED. SOME OF THE EFFECTS ARE MORE UPSTREAM PHYSIOLOGICALLY, AND THEREFORE CAUSE OTHERS. THE EFFECTS ON ANY GIVEN INDIVIDUAL DEPEND UPON THE TYPE OF EXPOSURE AS WELL AS THE SPECIES, GENDER, HEALTH, AGE OR TISSUE(S) INVOLVED. MECHANISMS DIFFER FROM SIGNS OF PATHOLOGY OR SYMPTOMS OF ILLNESS; RATHER, THEY EXPLAIN HOW SIGNS AND SYMPTOMS ARE INITIATED.

Home: OscillatoriumNewest version this mapDate of this update: 05-19-16

CELLULAR FUNCTIONS AND BEHAVIORS

Orientation of magnetite"Switching" of cryptochrome molecule

Enzyme functions, methionine synthaseGene expression, stress proteins, apoptosis

Clumping of some cells, movements of others

CELLULAR STRUCTURES

Molecular bonds of DNA, RNAAlterations in ATP production, different mechanisms

Membranes, cellular, subcellularResonance changes within fluid compartments

Receptors/channels within membranesConcentrations of ions, molecules, nutrients

TISSUE EFFECTS

Decreased integrity of blood-brain barrierBrain dysfunction: brainwaves, sensory disturbance

Brain developmental issues: autismBrain structural changes, beta-amyloid, tumors

Brain function, cognitive effects, abnormal proteinsCircadian changes in hormonal releases

Cardiovascular rhythm changesImmune response alterations

CASCADING MECHANISMSMOLECULAR TO MULTI-SPECIES

Free radical cascadesCalcium influx and cellular activity

Field reorientation of ions, cellsSingle species gene pool disruptions

Multi-species trophic cascade