end-replication problem

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End- replication problem

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End-replication problem. Repetición telomérica : TTAGGG. Mecanismo de acción de la telomerasa. Extremo 3´ DNA telomérico. Actividad de telomerasa: Ensayo TRAP. Actividad de telomerasa: Ensayo TRAP. Límite de Hayflick. Determinación del largo del telómero. - PowerPoint PPT Presentation

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End-replication problem

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Repetición telomérica: TTAGGG

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Mecanismo de acción de la telomerasa

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Extremo 3´ DNA telomérico

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Actividad de telomerasa:

Ensayo TRAP

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Actividad de telomerasa:

Ensayo TRAP

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Límite de Hayflick

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Determinación del largo del telómero

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Reducción telómerica en sucesivas generaciones

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Estabilización del telómero por la telomerasa

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Cancer and telomerase

What price immortality?

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Blasco (2005) Nature Reviews Genetics 6, 611-622

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Extensión de la vida de células somáticas por expresión de

telomerasa

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¿Qué pasa con estos ratones?

• mRT -/-• p16INK4a -/- ; ARF -/-• mRT -/- ; p16INK4a -/- ; ARF -/-• p53 -/-• p53 -/- ; mRT -/-

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