endoplasmic reticulum stress visualization …...despite a half century of structural, biophysical...

Biomedicine springer.com/NEWSonline

18

P. Agostinis, K.U.Leuven, Belgium; S. Afshin, National University of Ireland, Galway, Ireland (Eds.)

Endoplasmic Reticulum Stress in Health and DiseaseContents Preface. Part I: Cellular responses to ER stress.-1 Biology of the endoplasmic reticulum.-2 A tight-knit group: protein glycosylation, endoplas-mic reticulum stress and the unfolded protein response.-3 ER stress signaling pathways in cell survival and death.-4. Eendoplasmic reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection.-5 ER stress and upr through dysregulated er ca2+ homeostasis and signaling.-6 Regulation of ER stress responses by micrornas.-7 ER stress as modulator of autophagy pathways.-8 physiological ER stress: the model of insulin-secreting pancreatic β-cells.Part II: ER stress in physiological & pathological conditions.-9 Pathological ER stress in b cells.-10 Endoplasmic reticulum stress and the unfolded protein response in lipid metabolism and obesi-ty.-11 ER stress and inflammation.-12 ER stress in intestinal inflammatory disease.-13 Role of ER stress in dysfunction of the nervous system.-14 Endoplasmic reticulum (ER) stress in amyotrophic lateral sclerosis (als).-15 Cardiovascular disease and endoplasmic reticulum stress.-16 Signaling the unfolded protein response in cancer.-17 Upr activation in cancer cells: a double-edged sword.-18 Contribution of ER stress to immuno-genic cancer cell death.-19 current advances in ER stress intervention therapies. Index

Fields of interestsBiomedicine general; Molecular Medicine; Cell Biology

Target groupsResearch

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2012. I, 349 p. 37 illus., 24 in color. Hardcover7 $209.00ISBN 978-94-007-4350-2

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E. Badoer, RMIT University, Bundoora, VIC, Australia (Ed.)

Visualization TechniquesFrom Immunohistochemistry to Magnetic Resonance Imaging

Features 7 Covers the top methods of visualizing neuro-chemistry 7 Features step-by-step procedures to guide readers through key experiments 7 Inclu-des key tips and detailed implementation advice to ensure quality results

Contents Multiple Immunohistochemical Labelling of Peri-pheral Neurons.- Combined In Situ Hybridization and Immunohistochemistry in Tat Brain Tissue Using Digoxigenin Labelled Riboprobes.- In Situ Hybridization within the CNS Tissue: Combining In Situ Hybridization with Immunofluorescence.- Visualizing GABAB Receptor Internalization and Intracellular Trafficking.- Using Total Internal Reflection Fluorescence Microscopy (TIRFM) to Visualize Insulin Action.- Live-Cell Quantification of Mitochondrial Functional Parameters.- Func-tional Imaging Using Two-Photon Microscopy in Living Tissue.- Calcium Imaging Techniques In Vitro to Explore the Role of Dendrites in Signaling Physiological Action Potential Patterns.- Juxtacel-lular Labeling in Combination with Other His-tological Techniques to Determine Phenotype of Physiologically Identified Neurons.- Visualization of Activated Neurons Involved in Endocrine and Dietary Pathways Using GFP-Expressing Mice.- Use and Visualization of Neuroanatomical Viral Transneuronal Tracers.- Visualization of Thermal Changes in Freely Moving Animals.- Perfusion Magnetic Resonance Imaging Quantification in the Brain.

Fields of interestsNeurosciences; Neurochemistry; Diagnostic Radiology

Target groupsProfessional/practitioner

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Due June 2012

2012. XVII, 355 p. 80 illus., 56 in color. (Neuromethods, Volume 70) Hardcover7 $139.00ISBN 978-1-61779-896-2

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C. S. Carter, University of California at Davis, Sacramento, CA, USA; J. W. Dalley, University of Cambridge, UK (Eds.)

Brain Imaging in Behavioral NeuroscienceFeatures 7 An up-to-date and comprehensive survey of brain imaging studies in health and di-sease 7 Contributions from world leading authorities on magnetic resonance imaging and positron emission tomography 7 Strong focus on recent conceptual and methodological advan-ces in neuroimaging research

Contents From the contents.- Preface.- Food and drug reward: overlapping circuits in human obesity and addiction.- Nonhuman Primate Models of Addiction and PET Imaging: Dopamine System Dysregulation.- Neural and behavioral endophe-notypes in ADHD.- Experimental protocols for behavioral imaging: Seeing animal models of drug abuse in a new light.- Molecular Imaging and the Neuropathologies of Parkinson’s disease.- Imaging of Seasonal Affective Disorder and Seasonality effects on serotonin and dopamine function in the Human Brain.- Magnetic resonance spectroscopic methods for the assessment of metabolic functions in the diseased brain.- MR Spectroscopic Studies of the Brain in Psychiatric Disorders.- fMRI As A Measure of Cognition Related Brain Circuit-ry In Schizophrenia.- MRI studies in Late-Life Mood Disorders.- The role of diffusion tensor imaging in the study of cognitive aging.- Structu-ral, functional and spectroscopic MRI studies of Methamphetamine addiction.- Pharmacological MRI Approaches to Understanding Mechanisms of Drug Action.

Fields of interestsNeurosciences; Imaging / Radiology; Nuclear Medicine


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2012. Approx. 500 p. (Current Topics in Behavioral Neurosciences, Volume 11) Hardcover7 approx. $239.00ISBN 978-3-642-28710-7

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www.springer.com/978-94-007-4350-2



News 4/2012 Biomedicine

19

A. R. Coates, University of London, UK (Ed.)

Antibiotic ResistanceThis book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resis-tance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a coll-ection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria.

Features 7 This book provides views about antibiotic resistance from world experts in the field 7 The book has constructive ways in which to combat resistance,such as combinations of antibiotics, and targeting non-multiplying bacteria 7 It provides an outline of the challenges of the future, namely the need for a rebirth of the golden age of antibiotics in the mid-20th Century when 20 new classes of antibiotics reached the market

Contents Preface.- Introduction to antibiotic resistance.- Origins of antibiotic resistance.- Surveillance Programs and Antibiotic Resistance: Worldwide and Regional Monitoring of Antibiotic Resistance Trends.- Current and future challenges in the de-velopment of antimicrobial agents.- Resistance in Gram-negative bacteria.- Non-multiplying bacte-ria are profoundly tolerant to antibiotics.- Preven-tion of drug resistance by multidrug treatment of tuberculosis.- Persister cells–molecular mecha-nisms related to antibiotic tolerance.- Antimicro-bial textiles.- Efflux – how bacteria use pumps to control their micro-environment.- Antibiotics in Phase II and III clinical trials.

Fields of interestsPharmacology/Toxicology; Drug Resistance; Medical Microbiology


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2012. Approx. 350 p. 40 illus. (Handbook of Experimental Pharmacology, Volume 211) Hardcover7 approx. $419.00ISBN 978-3-642-28950-7

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New SeriesNanobioengineering SeriesNanobioengineering is a new, truly multidis-ciplinary discipline comprising very diverse backgrounds such as chemistry, physics, material science, electronic engineering, pharmacy and molecular biology. The “Nanobioengineering Series” welcomes state-of-the-art, current studies and new developments in topics such as: - Apply-ing nanotechnology to the development of new biomedical systems and devices; - Physical and chemical functionalization of materials for the study of biomolecule and cell interactions and for the development of new biosensors; - Protocols, methods, instrumentation, and applications of nanotechnology in biology; - Tissue engineering; - Legal doctrines relevant to nanotechnology commercialization; - Societal implications and economical impacts of nanotechnology; among others.

F. Crespilho, Universidade Federal do ABC (UFABC), Santo André-SP, Brazil (Ed.)

NanobioelectrochemistryNanobioelectrochemistry covers the modern aspects of bioelectrochemistry, nanoscience and materials science. The combination of nanostruc-tured materials and biological molecules enables the development of biodevices capable to detect specific substances. Furthermore, by using the bioelectrochemistry approach, the interaction between bio-systems and nanostructured mate-rials can be studied at the molecular level, where several mechanisms of molecular behavior are elucidate from redox reactions. The combination of biological molecules and novel nanomaterials components is of great importance in the process of developing new nanoscale devices for future biological, medical and electronic applications.

Features 7 Covers modern aspects of bioelectroche-mistry 7 Describes different electrochemical techniques for patterning electrode surfaces with biomimetic systems 7 Written by leading experts and pioneers in the field

Contents Nanoscience-based electrochemical sensors and arrays for detection of cancer biomarker proteins.- Nanomaterials for Biosensors and Implantable Biodevices.- Nanomaterials for enzyme biofuel cells.- Biosensors based on Field-Effect De-vices.- Using supramolecular chemistry strategy for mapping electrochemical phenomena on the nanoscale.- DNA AND ENZYME-BASED ELECTROCHEMICAL BIOSENSORS: ELEC-TROCHEMISTRY AND AFM SURFACE CHA-RACTERIZATION.- Electrochemical-Surface Plasmon Resonance: Concept and Bioanalytical Applications.

Fields of interestScience, general


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2012. 350 p. (Nanobioengineering Series) Hardcover7 approx. $179.00ISBN 978-3-642-29249-1

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20

V. A. Erdmann, Free University of Berlin, Germany; J. Barciszewski, Polish Academy of Sciences, Poznan, Poland (Eds.)

From Nucleic Acids Sequences to Molecular MedicineDespite a half century of structural, biophysical and biochemical investigations of ribonucleic acids, they are still mysterious. RNAs stand at fer-tile crossroads of disciplines, integrating concepts from genomics, proteomics, dynamics as well as biochemistry and molecular biology.

Features 7 The book covers hot topics such as small inter-ference RNAs for gene silencing in molecular bio-logy and medicine 7 Written by leading experts in the field 7 With numerous illustrations

Contents From the contents.- Preface.- RNA (center of the) World. Non-coding RNAs: Identification of Cancer-Associated microRNAs. Antisense Oligonucleotides in the Treatment of Malignant Gliomas. The diverse active sites in splicing, de-branching and microRNA processing around RNA phosphodiester bonds. Activation and Deactiva-tion of Antisense Function with Light. Targeting catalytic RNAs into mitochondria for functional analyses and inverse genetics. Ribozymes as molecular biology reagents. Natural antisense transcripts mediate regulation of gene expression. Hammerhead ribozymes against virus and viroid RNAs. Chemical modification of short shRNAs. Antisense for treatment of cancer: the present and the future. Targeting non-coding RNAs for cancer therapy. Suppression of hepatitis C viral genome replication with Functional Antisense Oligonucle-otides. Antisense-mediated reduction of eukary-otic non-coding RNAs.

Fields of interestsMolecular Medicine; Nucleic Acid Chemistry; Human Genetics


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2012. VI, 695 p. 120 illus., 46 in color. (RNA Technologies) Hardcover7 $239.00ISBN 978-3-642-27425-1

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M. Ergüven, Yeni Yüzyıl University Faculty of Medicine, Turkey; T. Muramatsu, Aichi Gakuin University, Japan; A. Bilir, Istanbul University Faculty of Medicine, Turkey (Eds.)

Midkine: From Embryogenesis to Pathogenesis and TherapyContents PART I: General aspects of mıdkıne.-1 General information on midkine.-2The role of midkine in neural development and patterning.-3Midkine- A player in innate immunity.-4 Midkine/p63 axis in regulation of epithelial-mesenchymal transition.-5 Immunochemical methods for the detection of midkine in samples of human origin.-6 Circu-lating midkine in malignant, inflammatory, and infectious diseases: a systematic review.II Mıdkıne and ınflammatıon.-7 Midkine in inflammation and inflammatory diseases.-8 Rheumatoid arthri-tis and midkin.III Mıdkıne and the cardıovascular system.-9 Midkine and heart failure.-10 Vascular restenosis and midkine.-11 The potential of MK through the renin-angiotensin system.IV Mıdkıne and the nervous system.-12 Midkine and Multiple sclerosis.-13 MK gene transfer in brain infarc-tion.-14 Midkine in psychiatric and neurodegene-rative diseases.V Mıdkıne and the urogenıtal sys-tem, reproductıon and agıng.-15 Role of midkine in nephrogenesis and kidney Disease.-16 Midkine, a factor promoting cytoplasmic maturation of oo-cytes.-17 Endometriosis may be promoted by mid-kine: possible involvement of ovarian follicles.-18 Stem cells and midkine.-19 Midkine in skeletal physiology.VI Mıdkıne and cancer.-20 Midkine and chemotherapy resistance in cancers.-21 A gene medicine with the midkine transcriptional regulation as new cancer therapeutics.-22 Midki-ne as a tumor shared antigen.-23 Midkine in pros-tate cancer.-24 Midkine is a potential therapeutic target of hepatocellular carcinoma. [...]

Fields of interestsBiomedicine general; Medicine/Public Health, general; Life Sciences, general


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2012. X, 380 p. 54 illus., 24 in color. Hardcover7 $209.00ISBN 978-94-007-4233-8

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New SeriesSpringerBriefs in Biochemistry and Molecular BiologySpringer Briefs in Biochemistry and Molecular Biology are a series of slim high quality publi-cations encompassing the entire spectrum of biochemistry and molecular biology. Each indi-vidual proposal will be evaluated by hand-picked external reviewers to ensure publication of Sprin-ger Briefs of the highest standard. Springer Briefs published in the series represent the cutting edge in biochemistry and molecular biology research in a format intersecting the traditional review and the scientific book volume.




21

D. Escors, University College London, UK; K. Breckpot, Free University Brussels, Jette, Belgium; F. Arce, University College London, UK; G. Kochan, University of Oxford, UK; H. Stephenson, University College London, UK

Lentiviral Vectors and Gene TherapyContents 1 Introduction to gene therapy.- 1.1 The concept of gene therapy.- 1.2 Origins of gene therapy.- 1.3 Gene therapy in the 1970s.- 1.4 Gene therapy in the 1980s.- 1.5 The breakthroughs in gene therapy from the 1990s and 2000s.- 1.6 Current human gene therapy and lentiviral vectors.- 1.7. Conclu-ding remarks.- 2 Development of retroviral and lentiviral vectors.- 2.1 Retrovirus biology.- 2.2 Vectors based on γ -retroviruses.- 2.3 Vectors based on lentiviruses.- 2.4 Summary and conclu-sions.- 3 Cell and tissue gene targeting with lenti-viral vectors.- 3.1 Introduction.- 3.2 Modification of lentivector tropism by pseudotyping (surface targeting).- 3.3 Transcriptional targeting.- 3.4 Post-transcriptional targeting.- 3.5 Conclusions.- 4 Immunomodulation by genetic modification using lentiviral vectors.- 4.1 Introduction to genetic immunotherapy.- 4.2 Lentivector gene therapy for immunization.- 4.3 Lentivector gene therapy for the treatment of autoimmune disease.- 4.4 Con-clusions.- 5 Clinical grade lentiviral vectors.- 5.1 Introduction.- 5.2 Good manufacturing practise guidelines and clinical grade vector preparations.- 5.3 Scaling-up lentivector production for clinical application.- 5.4 Purity of clinical grade lentivec-tors.- 5.5 Biosafety.- 5.6 Final considerations and conclusions.- 6 Human gene therapy with retrovi-rus and lentivirus vectors.- 6.1 Introduction.- 6.2 Correction of Severe Combined Immunodefici-ency-X1.- 6.3 Correction of X-linked chronic gra-nulomatous disease.- 6.4 Correction of X-linked adrenoleukodystrophy. [...]

Fields of interestsGene Therapy; Immunology; Genetic Engineering


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Available

2012. IX, 104 p. 10 illus., 9 in color. (SpringerBriefs in Biochemistry and Molecular Biology) Softcover7 $49.95ISBN 978-3-0348-0401-1

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A. A. Galoyan, Armenian Academy of Sciences, Yerevan, Armenia

Brain Immune System Signal Molecules in Protection From Aerobic and Anaerobic InfectionsFeatures 7 Written by a pioneer of the specialized field of neuroimmunology 7 Presents a full overview of the neuroimmune system 7 Useful to academics, researchers, and PhD students in neuroscience and neurobiology

Contents The Cytokine System.- The Discovery of the Brain Immunomodulalors.- Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines by NSO and NPV of Hypo-thalamus.- Antibacterial and Antiviral Activity of Galarmin (PRP-1) and Some Immunological Me-chanisms of its Action.- Treatment and Prophy-laxis of Anthrax by Galarmin: Receptor Tyrosine Kinase is a Target of Galarmin.- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Infection by Galarmin and D-15 Galarmin in Vivo.- Treatment of Clostridium Perfringens-Induced Gas Gangrene by New Cy-tokines of Brain.- Investigation of Protective and Immunogenic Properties of Hypothalamic Proline Polypeptides Galarmin and Gx-NH2 Against Mycobacterium Tuberculosis.- Brain - Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone-Marrow Progenitor Cells.- Antioxidant-Antiradical and Electron Donating Functions of Galarmin and Gx-NH2.- Discussion.- Summary.Galarmin and Gx-NH2.- Discussion.- Summary.

Fields of interestsNeurosciences; Neurobiology


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Due May 2012

2012. X, 300 p. 80 illus., 44 in color. (Advances in Neurobiology, Volume 6) Hardcover7 $189.00ISBN 978-1-4614-3666-9

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M. Hayat, Kean University, NJ, USA (Ed.)

Stem Cells and Cancer Stem Cells, Volume 7Therapeutic Applications in Disease and Injury

Contents Preface. I. Regenerative medicine.-1Mesenchymal stem cell expansion for therapeutic application.-6 Mobilization of pluripotent stem cells in patients with myocardial ischemia: from the bench to bedside.-2 Role of induced pluripotent stem cells in regenerative medicine.-3 Sulforaphane as new therapeutic agent for targeting of cancer stem cells with focus to prostate and pancreatic cancer.-4 Technology platforms for heart regenerative therapy using pluripotent stem cells.-5 Myocardial regeneration of adipose tissue-derived stem cells: differentiation, paracrine, fusion mechanisms.-7 Mammary regeneration using embryonic stem cell engraftment.-8 Recovery of the bone marrow in lethally irradiated host: role of hyper-activated stem cell factor receptor.-9 Potential of bone marrow-derived stem cells in treatment of genetic diseases of the liver.-10 Propagation of human bone marrow stem cells for craniofacial applica-tions.-11 Maintenance of pluripotency in mouse stem cells: use of hyaluronan in the long-term cul-ture.-12 Initiation of soft tissue sarcomas: muscle stem/progenitor cells as targets.-13 Mesenchymal stem cells: complex players in lung repair & injury.II. Tissue engineering.-14 Human embryo-nic stem cell-derived mesodermal progenitors for bone engineering.-15 The role of chondrogenic factors in differentiation of bone marrow stromal cells to the cartilage lineage.-16 Chondrogenic differentation of human mesenchymal stem cells: effect of electromagnetic fields. [...]

Fields of interestsCancer Research; Oncology; Stem Cells


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2012. X, 296 p. 49 illus., 38 in color. (Stem Cells and Cancer Stem Cells, Volume 7) Hardcover7 $209.00ISBN 978-94-007-4284-0

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22

R. A. Huml, Quintiles, Durham, NC, USA

Pharmaceutical Competitive Intelligence for the Regulatory Affairs ProfessionalThis Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry. It provides an overview of processes that the regulatory affairs profes-sional must take into account when evaluating data impacting product-based risk evaluations. These apply particularly to evaluations that focus on outputs such as regulatory approval, or the commercial impact of product labeling on the sales forecast over a limited timeframe. The Brief also provides an overview of intellectual property assessment that can impact a product’s lifespan on the market due to patent protection itself (or loss of patent protection) or via regulatory exclusivity. Case examples are discussed to illustrate the im-portance of keeping up with the ever-changing regulations, and how to interpret them in the con-text of CI. In addition, there is a section on virtual data rooms (VDRs) which currently function as the cornerstone of due diligence investigations.

Feature 7 Provides a broad overview of the topic

Contents Introduction to Competitive Intelligence.- Overall Perspective of Due Diligence Investigations and Processes.- The Regulatory Functional Review – Primary Roles.- The On-Site Due Diligence/Data Room Meeting and Interactions with other Func-tional Area Experts.- Intellectual Property.- The Final Report.- Competitive Intelligence Summary.

Fields of interestPharmaceutical Sciences/Technology


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Due May 2012

2012. VI, 82 p. 3 illus., 2 in color. (SpringerBriefs in Pharmaceutical Science & Drug Development) Softcover7 $49.95ISBN 978-1-4614-3681-2

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B. Kadenbach, Philipps-University, Marburg, Germany (Ed.)

Mitochondrial Oxidative PhosphorylationNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

Contents Preface.- Introduction.- Mitochondrial Dynamics: The Intersection of Form and Function.- Biogene-sis of Mitochondrial Proteins.- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology.- Su-pramolecular Organization of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phospho-rylation.- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain.- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins.- Evolution of the Couple Cytochrome C and Cytochrome C Oxidase in Primates.- Reaction Mechanism of Mammalian Mitochondrial Cytochrome C Oxida-se.- Phosphorylation of Mammalian Cytochrome C and Cytochrome C Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease.- Individual Biochemical Behavior Versus Biological Robustness: Spotlight on the Regulation of Cytochrome C Oxidase.- Bigenomic Regulation of Cytochrome C Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism.- Cytochrome C Oxidase and its Role in Neurodegeneration and Neuroprotec-tion.- The Many Clinical Faces of Cytochrome C Oxidase Deficiency.- Index.

Fields of interestsHuman Genetics; Gene Expression; Cell Biology


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Due June 2012

2012. XIV, 380 p. 33 illus., 27 in color. (Advances in Experimental Medicine and Biology, Volume 748) Hardcover7 $209.00ISBN 978-1-4614-3572-3

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K. C. Keiler, Pennsylvania State University, PA, USA (Ed.)

Bacterial Regulatory RNAMethods and Protocols

Contents Bioinformatic Discovery of Bacterial Regulatory RNAs using SIPH.-How to Identify CRISPRs in Sequencing Data.-A Strategy for Identifying Non-coding RNAs using Whole-genome Tiling Arrays.-Genetic Screens to Identify Bacterial sRNA Regulators.-Competition Assays Using Barcoded Deletion Strains to Gain Insight Into Small RNA Function.-Use of Semi-quantitative Northern Blot Analysis to Determine Relative Quantities of Bacterial CRISPR Transcripts.-RNA Visualization in Bacteria by Fluorescence in Situ Hybridization.-RNA Structure Predic-tion: An Overview of Methods.-Crystallization of RNA-Protein Complexes: From Synthesis and Purification of Individual Components to Crystals.-Analysis of RNA Folding and Ligand Binding by Conventional and High-Throughput Calorimetry.-Use of Aptamer Tagging to Identify in vivo Protein Binding Partners of Small Regu-latory RNAs.-Gel Mobility Shift Assays to Detect Protein-RNA Interactions.-RNase Footprinting of Protein Binding Sites on an mRNA Target of Small RNAs.-Computational Identification of sRNA Targets.-Detection of sRNA-mRNA Interactions by Electrophoretic Mobility Shift Assay.-Activity of Small RNAs on the Stability of Targeted mRNAs in vivo.-Native Gel Electrophoresis to Study the Binding and Release of RNA Polymerase by 6S RNA.-Ribosome Purification Approaches for Studying Interactions of Regulatory Proteins and RNAs with the Ribosome.-Analysis of Aminoacyl- and Peptidyl-tRNAs by Gel Electrophoresis.- In vitro trans-translation Assays.

Fields of interestsHuman Genetics; Microbial Genetics and Geno-mics


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Due June 2012

2012. 285 p. 54 illus., 10 in color. (Methods in Molecular Biology, Volume 905) Hardcover7 $119.00ISBN 978-1-61779-948-8

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23

L. J. Langman, C. L. Snozek, Mayo Clinic, Rochester, MN, USA (Eds.)

LC-MS in Drug AnalysisMethods and Protocols

Contents An Introduction to Drug Testing – The Expanding Role of Mass Spectrometry.- LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Tech-nology for Drug Screening Assays.- LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices.- Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry.- Opi-ate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques.- Synthetic Opioid Analysis by LC-MS/MS.- The Determina-tion of Cannabinoids Using Liquid Chromatogra-phy with Mass Spectrometric Detection.- Cocaine and Metabolites by LC-MS/MS.- Quantitation of Amphetamine Type Stimulants by LC-MS/MS.- Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control.- LC-MS/MS Screen for Xenobiotics and Metabolites.- Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS.- Hypoglycemic Agent Screening by LC-MS/MS.- LC-MS/MS Method for the Detection of Common Laxatives.- Simultaneous Determination of Cyclosporine, Sirolimus and Ta-crolimus in Whole Blood Using Liquid Chroma-tography – Tandem Mass Spectrometry (LC-MS/MS).- Quantification of Tricyclic Antidepressants Using UPLC-MS/MS.- Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS.- Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry.- Therapeutic Drug Monito-ring of Tamoxifen Using LC-MS/MS..

Fields of interestsPharmacology/Toxicology; Spectroscopy/Spec-trometry


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Due July 2012

2012. 210 p. 38 illus., 4 in color. (Methods in Molecular Biology, Volume 902) Hardcover7 approx. $119.00ISBN 978-1-61779-933-4

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B. Pascal, University of Glasgow, UK; S. Campanella, Brugmann University Hospital, Brussels, Belgium; T. Ethofer, University of Tubingen, Germany (Eds.)

Integrating Face and Voice in Person PerceptionContents Multisensory Recognition in Vertebrates (Espe-cially Primates).- Cross-Modal representation in Humans and Non-Human Animals: A Compara-tive Perspective.- Representation and Integration of Faces and Vocalizations in the Primate Ventral Prefrontal Cortex.- Intersensory Perception of Faces and Voices in Infants.- The Early Develop-ment of Processing Emotions in Face and Voice.- Audiovisual Integration in Speaker Identification.- Cross-Modal Integration of Identity and Gender Information Through Faces and Voices Involves a Similar Cortical Network.- Neurophysiological Correlates of Face and Voice Integration.- Integra-tion of Face and Voice During Emotion Percepti-on: Is There Anything Gained for the Perceptual System Beyond Stimulus Modality Redundancy?.- Cross-Modal Modulation of Spatial Attention by Emotion.- Audiovisual Integration of Emotional Information from Voice and Face.- Audiovisual Integration of Emotional Information from Voice and Face.- Crossmodal Integration of Emotional Stimuli in Alcohol Dependence.- The Role of Audition in Audiovisual Perception of Speech and Emotion in Children With Hearing Loss.- The Role of Audition in Audiovisual Perception of Speech and Emotion in Children With Hearing Loss.

Fields of interestsNeurosciences; Cognitive Psychology; Neurology


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Due June 2012

2012. Approx. 450 p. 48 illus., 34 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-3584-6

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G. Proetzel, The Jackson Laboratory, Bar Harbor, ME, USA; H. Ebersbach, Novartis Pharma AG, Basel, Switzerland (Eds.)

Antibody Methods and ProtocolsFeatures 7 Covers general considerations about an-tibody generation, antibody formats, and platforms 7 Highlights innovative approa-ches 7 Features expert tips on troubleshooting and avoiding known experimental pitfalls

Contents Antigen Presentation for the Generation of Binding Molecules.- Recombinant Antibodies and In Vitro Selection Technologies.- Phage Display.- Generation of Human Fab Libraries for Phage Display.- Selection of Human Fab Libraries by Phage Display.- Ribosome Display.- Hybridoma Technology for the Generation of Monoclonal An-tibodies.- The Application of Transgenic Mice for Therapeutic Antibody Discovery.- Production of Human or Humanized Antibodies in Mice.- Im-mortalization of Human B Cells: Analysis of B Cell Repertoire and Production of Human Monoclonal Antibodies.- Kinetic Screening in the Antibody Development Process.- Temperature-Dependent Antibody Kinetics as a Tool in Antibody Lead Se-lection.- Determination of Antibody Glycosylation by Mass Spectrometry.- Cloning, Expression, and Purification of Monoclonal Antibodies in scFv-Fc Format.- PEGylation of Antibody Fragments for Half-Life Extension.- Bispecific Antibody Derivatives Based on Full-Length IgG Formats.- Generation of Fluorescent IgG Fusion Proteins in Mammalian Cells.- Methods to Engineer and Identify IgG1 Variants with Improved FcRn Bin-ding or Effector Function.- Class-Specific Effector Functions of Therapeutic Antibodies.

Fields of interestsImmunology; Antibodies


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Due June 2012

2012. X, 374 p. 55 illus., 16 in color. (Methods in Molecular Biology, Volume 901) Hardcover7 $139.00ISBN 978-1-61779-930-3

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24

M. S. Rao, Invitrogen Corporation, Frederick, MD, USA; M. Carpenter, Carpenter Group Consulting, Inc., Black Diamond, WA, USA; M. C. Vemuri, Life Technologies, Frederick, MD, USA (Eds.)

Neural Development and Stem CellsThis expanded and updated edition reflects the enormous increase in our knowledge of the deve-lopment of the nervous system and the use of neu-ral stem cells in clinical applications. Integrating new information about the use of development of neural stem cells for clinical applications, Drs.

Features 7 Includes new information about develop-ment of neural stem cells for clinical applica-tions 7 Offers new chapters on neural trans-plantation and development of neural stem cells using reprogramming technologies 7 Describes derivation of neural cells from embryonic stem cells and induced pluripotent stem cells

Contents Defining Neural Stem Cells and Their Role in Nor-mal Development of the Nervous System.- Emb-ryonic Stem Cells and Neurogenesis.- The Cellular and Molecular Properties of Multipotent Neural Stem Cells.- Multipotent Stem Cells in the Emb-ryonic Nervous System.- Neural Crest Formation and Diversification.- Glial Nature of Adult Neural Stem Cells: Neurogenic Competence in Adult Astrocytes.- Neural Stem Cell Death Regulation in Nervous System Development and Disease.- Stem Cells of the Adult Olfactory Epithelium.- Retinal Stem Cells.- Transdifferentiation in the Nervous System.- Neural and Dopaminergic Differentiation of Human Pluripotent Stem Cells.- Mobilization of Neural stem cells in the Adult Central Nervous System.- Stem Cell Pathways in Brain Tumors.

Fields of interestNeurosciences


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Due July 2012

3rd ed. 2012. VIII, 317 p. 27 illus., 14 in color. (Stem Cell Biology and Regenerative Medicine) Hardcover7 approx. $209.00ISBN 978-1-4614-3800-7

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Reviews of Physiology, Biochemistry and PharmacologySeries editors: S. G. Amara, R. Jahn, R. Lill, B. Nilius, O. H. Petersen, T. Gudermann, S. Offermanns

Volume 162

B. Nilius, KU Leuven, Belgium; S. G. Amara, University of Pittsburgh, PA, USA; T. Gudermann, Walther-Straub-Institut für Pharmakologie und Toxikologie, München., Germany; R. Jahn, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany; R. Lill, University of Marburg, Germany; S. Offermanns, Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim, Germany; O. H. Petersen, Cardiff School of Biosciences, UK (Eds.)

Reviews of Physiology, Biochemistry and PharmacologyVolume 162

Cardiac ion channels and mechanisms for protection against atrial fibrillation. Intrinsically photosensitive retinal ganglion cells. Quantifying and modeling the temperature-dependent gating of TRP channels.

Fields of interestHuman Physiology


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Available

2012. X, 125 p. 19 illus., 15 in color. Hardcover7 approx. $139.00ISBN 978-3-642-29255-2

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R. F. Schmidt, University of Würzburg, Germany; G. F. Gebhart, University of Pittsburgh, PA, USA (Eds.)

Encyclopedia of PainThis is the most comprehensive overview available anywhere on the broad, multi-faceted and com-plex topic of pain – and the rapidly evolving scien-tific and medical disciplines that seek to under-stand, assess and treat pain. The second edition of the Encyclopedia of Pain is fully updated and has been expanded by over 100 new essays.It includes more than 3,000 entries and provides clear, de-tailed and up-to-date coverage of the current state of research, and treatment of pain.

Features 7 Expanded - Now contains over 3,000 entries – keynotes, in-depth essays and reviews 7 Clearly structured essays with extensive cross-references between keywords and related articles 7 Elect-ronic edition available on SpringerReference with links to all relevant related publications

Fields of interestsNeurosciences; Pain Medicine; Psychiatry


Discount groupMR

Available

Print 2nd ed. 2013 2013. Approx. 3200 p. 1000 illus., 500 in color. (In 4 volumes, not available separately) 7 approx. $2050.00ISBN 978-3-642-28752-7

9<HTOGPC=cihfch> eReference7 approx. $2050.00ISBN 978-3-642-28753-4

9<HTOGPC=cihfde> Print + eReference7 approx. $2550.00ISBN 978-3-642-28754-1

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25

A. T. Slominski, University of Tennessee, Health Science Center, Memphis, TN, USA; M. A. Zmijewski, Medical University of Gdansk, Poland; C. Skobowiat, B. Zbytek, R. M. Slominski, J. D. Steketee, University of Tennessee, Health Science Center, Memphis, TN, USA

Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin‘s Neuroendocrine SystemThe skin, the body’s largest organ, is strategically located at the interface with the external environ-ment where it detects, integrates and responds to a diverse range of stressors, including solar radiati-on. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), bio-logical factors (infectious and non-infectious) and other physical and chemical agents.

Contents Introduction.- Biogenic amines in the skin.- Me-latoninergic system in the skin.- Cutaneous cho-linergic system.- Corticotropin signaling system in the skin.- Steroidogenesis in the skin.- Equivalent of hypothalamo-pituitary adrenal axis in the skin.- Cutaneous secosteroidal system.- Equivalent of hypthalamic-pituitary-thyroid axis.- Cutaneous opioid system.- Cutaneous endocannabinoid sys-tem.- Perspectives.- References.- Subject index.

Fields of interestsNeurosciences; Dermatology


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2012. X, 135 p. 23 illus., 17 in color. (Advances in Anatomy, Embryology and Cell Biology, Volume 212) Softcover7 $139.00ISBN 978-3-642-19682-9

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W. H. Sommer, R. Spanagel, Central Institute of Mental Health (ZI) Mannheim, Germany (Eds.)

Behavioral Neurobiology of Alcohol AddictionBesides contributing a comprehensive collection of reference material accompanied by critical discussions for the seasoned scholars, Current Topics in Behavioral Neurobiology of Alcohol Addiction aims towards new disciples in addiction research as well as interested readers from other fields of study by providing lucid presentations of these topics that are written by an assembly of highly distinguished experts and leaders in their respective research areas.

Features 7 Covers the latest insights into alcohol addiction research and provides effective treatment solu-tions 7 Written by highly distinguished experts and leaders in the field 7 With numerous illustrations

Contents From the contents.- Preface.- Part 1: Mechanistic aspects underlying alcoholism.- Part 2: Genetics.- Part 3: Clinical phenotypes and preclinical models thereof.- Part 4: Novel insights from brain ima-ging.- Part 5: Translational aspects and medication development.

Fields of interestsNeurosciences; Psychiatry; Psychopharmacology


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2012. Approx. 450 p. (Current Topics in Behavioral Neurosciences, Volume 13) Hardcover7 approx. $239.00ISBN 978-3-642-28719-0

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K. Suhre, Weill Cornell Medical College, Doha, State of Qatar (Ed.)

Genetics Meets Metabolomicsfrom Experiment to Systems Biology

Contents Introduction.- Pre-conditions for high quality biobanking in large human epidemiological cohorts for metabolomics and other -omics studies.- Assay Tools for Metabolomics.- Statistical methods in genetic and molecular epidemiology and their application in studies with metabolic phenotypes.- Ultrahigh resolution mass spectro-metry based non-targeted microbial metabolo-mics.- etabolomic systems biology of protozoan parasites.- Mouse genetics and metabolic mouse phenotyping.- Metabolomics in animal breeding.- Metabolomics applications in human nutrition.- Metabolomics for the individualized therapy of androgen deficiency syndrome in male adults.- Systems biology resources arising from the human metabolome project.- Understanding cancer metabolism through global metabolomics.- Gene-tic and metabolic determinants of fatty acid chain length and desaturation, their incorporation into lipid classes and their effects on risk of vascular and metabolic disease.- Mapping metabolomic quantitative trait loci (mQTL) – A link between metabolome-wide association studies and systems biology.- Metabolic traits as intermediate phe-notype.- Genome-wide association studies with metabolomics.- Systems biology meets metabo-lism.- Index.

Fields of interestsHuman Genetics; Metabolomics; Systems Biology


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Due May 2012

2012. XXV, 332 p. 76 illus., 47 in color. Hardcover7 $209.00ISBN 978-1-4614-1688-3

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26

R. Toman, Slovak Academy of Sciences, Bratislava, Slovakia; R. A. Heizen, National Institutes of Health, Hamilton, MT, USA; J. E. Samuel, Texas A&M, College Station, TX, USA; J.-L. Mege, Université de la Méditerranée, Marseille, France (Eds.)

Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever BacteriumContents 1. History and prospects of Coxiella burnetii research. - 2. Phylogenetic diversity, virulence and comparative genomics. - 3. Defense mechanisms against oxidative stress in Coxiella burnetii: Adap-tation to a unique intracellular niche. - 4. Lipopo-lysaccharide of Coxiella burnetii. - 5. Components of protective immunity. - 6. Proteome of Coxiella burnetii. - 7. Coxiella subversion of intracellular host signaling. - 8. The Coxiella burnetii parasito-phorous vacuole. - 9. Coxiella burnetii secretion systems. - 10. Role of lipids in Coxiella burnetii infection. - 11. Axenic growth of Coxiella burnetii. - 12. Developmental biology of Coxiella burnetii. - 13. Genetic manipulation of Coxiella burnetii. - 14. Role of innate and adaptive immunity in the control of Q fever. - 15. Immune response and Co-xiella burnetii invasion. - 16. Antigenic analysis for vaccines and diagnostics. - 17. Epidemic Q Fever in humans in the Netherlands. - 18. Coxiella-like endosymbionts. - 19. Molecular typing of Coxiella burnetii (Q fever).

Fields of interestsBiomedicine general; Cell Biology; Genetic Engi-neering


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2012. X, 430 p. 36 illus., 22 in color. Hardcover7 $209.00ISBN 978-94-007-4314-4

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V. Voynov, MedImmune, LLC, Gaithersburg, MD, USA; J. A. Caravella, Biogen Idec, Cambridge, MA, USA (Eds.)

Therapeutic ProteinsMethods and Protocols

Contents Therapeutic Proteins.- Synthetic Antibody Lib-raries.- The Construction of ‘Phylomer’ Peptide Libraries as a Rich Source of Potent Inhibitors of Protein/Protein Interactions.- Ribosome Display and Screening for Protein Therapeutics.- Yeast Display of Engineered Antibody Domains.- De-sign, Expression, Purification, and Characteri-zation of Engineered Antibody CH2 and VH Domains.- Engineering of Affibody Molecules for Therapy and Diagnostics.- Protein Design for Diversity of Sequences and Conformations Using Dead-End Elimination.- Design and Generati-on of DVD-IgTM Molecules for Dual-Specific Targeting.- Engineering and Expression of Bibody and Tribody Constructs in Mammalian Cells and in the Yeast Pichia pastoris.- Use of E. coli for the Production of a Single Protein.- Folding Enginee-ring Strategies for Efficient Membrane Protein Production in E. coli.- Transient Expression Technologies: Past, Present, and Future.- Stable Transfection Pools for Large Quantity of Protein Production.- Mammalian Stable Expression of Biotherapeutics.- Transgenic Expression of Therapeutic Proteins in Arabidopsis thaliana Seed.- Methods for Chromatographic Removal of Endotoxin.- Effectiveness of Various Processing Steps for Viral Clearance of Therapeutic Proteins: Database Analyses of Commonly-Used Steps.- High-Throughput Quantitative N-Glycan Analysis of Glycoproteins.- High-Throughput Multimodal Strong Anion Exchange Purification and N-Gly-can Characterization of Endogenous Glycoprotein Expressed in Glycoengineered Pichia pastoris.- Databases and Tools in Glycobiology. [...]

Fields of interestsPharmacology/Toxicology; Proteomics


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Due June 2012

2nd ed. 2012. XVI, 504 p. 107 illus., 50 in color. (Methods in Molecular Biology, Volume 899) Hardcover7 $139.00ISBN 978-1-61779-920-4

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endoplasmic reticulum stress visualization …...despite a half century of structural, biophysical...

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