endovascular treatment of the aorta - nmsuite...endovascular treatment of the aorta with fenestrated...
TRANSCRIPT
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Endovascular Treatment of the Aortawith Fenestrated and Branched Grafts
Eric LG Verhoeven,MD, PhD, A. Katsargyris, MDVascular and Endovascular Surgery,
Paracelsus Medical University, Nuremberg, Germany
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Disclosures
• William Cook Europe/Cook Inc.
– Consultant & Research grants
• W.L. Gore & Associates
– Consultant & Research grants
• Atrium Maquet
– Consultant
• Siemens
– Consultant
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Vascular surgery has changed…
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Purpose of F & B grafts
• To treat complex AAA and TAAA byendovascular means
• Important basic rule: strong fixation andsealing proximally
• Custom made, individually tailored grafts
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F&B Procedures per year
0
20
40
60
80
100
120
140
160
01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 17 18
TAAA
All Cases
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Lay-out
• Complex Abdominal Aortic Aneurysms
• Thoraco-abdominal Aneurysms
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Complex Abdominal Aneurysms
• AAA with shorter
proximal neck
• Juxtarenal AAA
• Suprarenal AAA
• Thoraco-abdominal
aneurysms (TAAA)
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Complex Abdominal Aneurysms
• AAA with shorter
proximal neck
• Juxtarenal AAA
• Suprarenal AAA
• Thoraco-abdominal
aneurysms (TAAA)
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Solution: Fenestrated Grafts
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Fenestrated EVARGoal
• Achieve sealing in short or absent neck
• Position of first sealing stent
– better portion aorta
– completely in neck
• Turn a short/no neck into a long neck...
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Fenestrated TechniqueMaturity
• Catheterization of target vessels
• Stenting of small fenestrations
– Atrium covered stents
• Technical tricks:
– Tilting, Flairing, Relining
• Long overlap between components
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Fenestrated TechniqueComposite System
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Bridging Stent-grafts
• Balloon-expandable
– Atrium V12
– Life Stream
– Bentley
– Jotec
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2x, 3x, or 4x FEVARChoice According to Landing Zone
JVS 2015;62:319-25
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Evolution of Stent-graft Design
8165 68 64
5025
10 4 2
1935 32 36
5075
90 96 98
0
20
40
60
80
100
120
2010 2011 2012 2013 2014 2015 2016 2017 2018
2x FEVAR (%) 3x-4x FEVAR (%)
↑ Use of 3x-4x FEVAR over the years…
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F-EVAR Technique
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Indication?
• Cardio-Pulmonary Contra-Indications
• Hostile abdomen
• Redo Aortic surgery
– After EVAR
– After Open Surgery
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Indication?
• Cardio-Pulmonary Contra-Indications
• Hostile abdomen
• Redo Aortic surgery
– After EVAR
– After Open Surgery
• “Normal risk patients”
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Results Expert Centers
• Follow-up up to 10 years
• Early mortality: <2%
• Target vessel patency at 2 years: > 90%
• Dialysis during follow-up: < 2%
• Decrease of renal function: 10-20%
• Very few endoleaks type I
• No late rupture
•Greenberg et al. J Vasc Surg. 2009;50(4):730-737.
•Verhoeven et al. Eur J Vasc Endovasc Surg 2010;39(5):529-536.
•Amiot, Haulon, et al. Eur J Vasc Endovasc Surg 2010;39(5):537-44.
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• 5-years experience with FEVAR
• 281 pts
• Mortality 0.7%
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Thoraco-abdominal Aneurysms
• AAA with shorter
proximal neck
• Juxtarenal AAA
• Suprarenal AAA
• Thoraco-abdominal
aneurysms (TAAA)
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Open repair for TAAA
Coselli et al. Ann Thorac Surg 2002
Safi et al. J Vasc Surg 1998
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Acute/Ruptured TAAA
Zenith t-Branch prosthesis
• The only off-the-shelf endovascular stent graft indicated to treat thoracoabdominalaneurysms
• Suitable for a wide range of TAAA anatomy
•Modular system
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TAB054
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TAB054Postop CTA
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Nuremberg Experience
• 300 Consecutive pts F&B stent-grafts for TAAA
• April 2004 – January 2017
• Suprarenal aortic aneurysms excluded
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Stent-graft Design
• Branches only
– N=93 (31.0%)
• Fenestrations only
– N=92 (30.7%)
• Branches + Fenestrations
– N=115 (38.3%)
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Postoperative Data
• Mortality
– 30d: N=18 (6.0%)
– In-hospital: N=21 (7.0%)
– ↑ in ASA IV vs. ASA ≤ III pts (25% vs 6.2%, p=0.006)
• Major complications
– N=78 (26.0%)
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Late Mortality
• All cause late mortality: N=42
– 2 Related deaths (aortoesophageal fistula, graft infection)
– ↑ Late mortality in ASA IV vs ASA ≤ III pts (50% vs 13.4%, p=0.004)
Estimated Survival83.2 ± 3% at 1 year79.1 ± 3.3% at 2 years70 ± 5.4% at 5 years
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• Avoid treating ASA IV?
• Or:
– Only if good anatomy?
– Evaluate Co-M better?
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Conclusion - TAAA
• Endovascular repair of TAAA
– Feasible
– ↓ M & M vs Open surgery
• ↓ SCI
– ↑ Reinterventions (endovascular)
– First choice in the great majority of pts
– Limitations….
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Prerequisites for EndovascularRepair of TAAA
• Team
• Set-up
– Hybrid room
– Stock
• High volume
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Conclusions
• Complex Abdominal AAA: endovascular firstchoice
• TAAA: endovascular whenever possible
• Our task is to select the best option (and graft/technique) for each patient, irrespectiveof……
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Endovascular Treatment of the Aortawith Fenestrated and Branched Grafts
Eric LG Verhoeven,MD, PhD, A. Katsargyris, MDVascular and Endovascular Surgery,
Paracelsus Medical University, Nuremberg, Germany