Enzogenol® improves brain function – A clinical trial

Brain Sciences Institute, Swinburne University, Melbourne

Enzogenol significantly improved cognitive performanceafter only 5 weeks of supplementation

ENZOGENOLENZOGENOL®®

Indications for use in:

1. Antioxidant 6. Nervous System Support

2. Heart Care 7. Brain Function7. Brain Function

3. Blood Circulation 8. Wound Healing

4. Diabetes Support 9. Skin Health

5. Eye Support 10. Beauty Applications

Enzogenol is a proanthocyanidin-rich polyphenol extract from the bark of New

Zealand grown Pinus Radiata trees produced by ENZO Nutraceuticals Ltd with patented

pure water extraction technology

Dosage : 100 - 1000 mg/day (depending on condition

& severity)

Brain Function Clinical StudyRandomized, double blind, controlled study

• 42 male subjects• Age 50-65 years• 5 week supplementation, daily:

Treatment: 960 mg of Enzogenol + 120 mg vitamin C

Control: 120 mg vitamin C

• Baseline, 5 weeks• Subjects: sedentary occupation, do not

exercise much, BMI > 26, non-smokers

Parameters measured1. Computerized Cognitive Testing

Testing performance of working memory using computer based tasks (response time and accuracy)

Spatial Working Memory Task (SWM)

Immediate Recognition Memory Task (IRM)

Target

Ready

Ready

yes no no yes

no no yes

ControlTreatment

20.00

0.00

-20.00

-40.00

-60.00

-80.00

Mea

n C

hang

e in

Res

pons

e Ti

me

(ms)

Ses

sion

2 -

Ses

sion

1

ImmediateRecognition

SpatialWorkingMemory

Error bars:+/- 1.00 SE

Ch

an

ge

in

Re

sp

on

se

Tim

e (

ms

)

Treatment Control

SWM IRM

SWM IRM

Enzogenol improves brain performance5 weeks of Enzogenol improved response times on Spatial Working Memory (SWM) by 64 ms & Immediate Recognition Memory (IRM) by 60 ms (p<0.05).

=> Reducing brain age by 7- 12 years

Parameters measured2. Brain Electrical Activity Testing /

Coherence AnalysesAnalyzing brain electrical activities and interactionof brain regions during working memory tasks

Can Enzogenol improve brain region communication ?

Brain Neuroimaging Analysis

Brain Activityon Correct Trial Performance

Comparing correct and incorrect trials shows:

Correct trial performance is strongly associated with long-range cortical decoupling (p<0.001)

Enzogenol improves brain communication5 weeks of Enzogenol changed brain activity patterns with a significant increase in long-range cortical decoupling that is strongly associated with correct decision making on these cognitive tests.

Retrieval Memory Task

Object Working Memory Task

=> Increased Brain Efficiency