epivax_ispri_non_confidential_june2014_bio2014
DESCRIPTION
EpiVax's in-silico immunogenicity prediction platform, ISPRI: • ISPRI: Unparalleled cloud-based epitope mapping toolset. Screen and compare unlimited protein therapeutics for immunogenicity. De-immunization algorithms also available (OptiMatrix). Used by scientists at the top biopharma companies. • PreDeFT Report: A comprehensive “FDA ready” in-silico immunogenicity analysis performed by experts at EpiVax (we use ISPRI for you). Often used in IND filings.TRANSCRIPT
ISPRI Interactive Protein Screening and Reengineering Interface
ISPRI Related Videos/Demos Here:
https://www.youtube.com/user/EpiVaxInc/
videos
EpiVax Mananiusment
Team www.epivax.com/about/management-team/
2
In Vivo In Vitro In Silico
Modify sequences to reduce
immunogenicity
Screen multiple therapeutic candidates
Human SCID
Mouse Model
HLA Transgenic
Mouse Model
Either
Examine:
• Non-sequence-
driven
immunogenicity
• Natural antigen
processing and
by DCs
• Peptide/MHC
stability
• T cell activation
thresholds
• Post-
translational
modification
• Formulation-
induced changes
Perform HLA Binding and T Cell
Assays with proteins /
target epitopes
Rank for immunogenicity
based on predicted
epitope content
Proceed to Drug
Development
Investigate artificial LN
Vary Ratio of T cells to dendritic
cells
Test PBMC Responses
The EpiVax Approach to Immunogenicity Screening
From: http://bit.ly/The_TCWP - T cell “White Paper”
ISPRI is an integrated, interactive set of tools
specifically designed for immunogenicity
analysis. ISPRI provides the depth of analysis
that is necessary to accurately predict clinical
immunogenicity
ISPRI vs. IEDB in silico services
Epitope Mapping
Cluster Analysis
ARB
NN-align
SMM align
Protein Re-engineering
Epitope Ranking
Epitope Mapping
EpiMatrix
ClustiMer /EpiBar
OptiMatrix
iTEM
Immunogenicity Scale
DeFT (OptiMatrix)
In Vitro / In vivo Assays
JanusMatrix
JMX-Adjusted Score
Target Selection
Tregitope Tolerization
IEDB is a collection of tools that are not integrated in any
coherent fashion. Epitope prediction is possible, but
seamless immunogenicity screening and protein re-
engineering is not.
Non-Confidential EpiVax
ISPRI: Developed for Biologics Available Tools
4
• EpiMatrix – Screen the protein sequences of product candidates for the presence of putative T cell epitopes.
• Immunogenicity Protein Scale – Rate the immunogenic potential of each submitted sequence on a normalized scale and compare
each protein to other immunogenic proteins and antibodies
• Tregitope Analysis – Identify within each submitted sequence putative regulatory T-cell epitopes (i.e. sub-regions
contained within the submitted sequences which may relate to natural regulatory T cells and which
may help to dampen the immune potential of the submitted antibody sequence)
• ClustiMer / EpiBar – Identify T-cell epitope clusters contained within product candidates
• Immunogenic Cluster Scale – Rate the immunogenic potential of each T-cell epitope cluster on a normalized scale and compare
each T-cell epitope cluster to other well-known immunogenic epitope clusters
• BlastiMer / JanusMatrix – Blast: Compare epitope clusters against the non-redundant protein or patent database at GenBank
– Homology: Compare epitopes to human genome epitopes that have the same TCR face.
• OptiMatrix – The protein re-design algorithm that provides a list of critical amino acid residues and potential
amino acid substitutions that are conserved in existing databases (based on published seque-
nces) and that do not introduce new epitopes.
Epitope Prediction EpiVax
6
•EpiVax uses EpiMatrix to predict epitopes
–matrix based prediction algorithm
•Can predict either class I or class II MHC binding
–MHC binding is a prerequisite for immunogenicity
–Full suite of HLA-based predictions are available; Class II usually used for biologics.
–Separate website available for vaccine design: iVAX
–http://www.epivax.com/vaccine-design-redesign/ivax-web-based-vaccine-design/
Mature
APC
MHC II Pocket
Epitope
Protein
Non-Confidential EpiVax
ISPRI EpiMatrix Protein Report
7
Frame Frame DRB1*0101 DRB1*0301 DRB1*0401 DRB1*0701 DRB1*0801 DRB1*1101 DRB1*1301 DRB1*1501
Start Stop Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score
1 DIQMTQSPS 9 0.91 0.17 0.35 0.06 0.09 0.86 -0.08 -0.01 0
2 IQMTQSPSS 10 2.15 1.35 2.26 1.58 2.17 1.88 2.24 2.52 6
3 QMTQSPSSL 11 1.11 0.28 0.5 0.96 0.29 0.39 0.9 0.4 0
4 MTQSPSSLS 12 1.87 2.26 2.02 1.88 1.06 1.66 1.79 2.05 7
5 TQSPSSLSA 13 0.51 0.28 1.31 0.69 -0.04 0.54 1.09 1.05 0. . . . . . . . . . . .. . . . . . . . . . . .
46 LLIYAASTL 54 1.41 1.08 0.99 2.16 1.54 0.85 2.28 2.3 3
47 LIYFASTLQ 55 1.91 1.85 2.46 2.07 1.79 1.08 1.79 2.1 7
48 IYFASTLQS 56 1.73 2.01 2.68 1.26 1.58 1.82 2.11 2.07 6
49 YFASTLQSG 57 0.64 1.6 0.59 0.32 1.42 1.28 0.04 1.09 0. . . . . . . . . . . .. . . . . . . . . . . .
98 FGQGKTVEI 106 0.7 1.9 -0.02 0.2 0.93 0.34 1.41 1.12 1
99 GQGKTVEIK 107 -0.28 -0.84 0.31 0.01 0.03 -0.57 -0.47 -1.24 0
DRB1*0101 DRB1*0301 DRB1*0401 DRB1*0701 DRB1*0801 DRB1*1101 DRB1*1301 DRB1*1501 Total
2.4 2.26 2.8 3.11 2.41 2.29 2.28 2.52 --
23.41 12.17 15.96 18.16 10.2 13.2 16.47 16.99 126.56
12 6 7 9 5 7 8 8 62
Deviation from Expectation: 38.46 Deviation per 1000 AA: 48.56
Adjusted for Regulatory Epitopes Deviation from Expectation: -21.24 Deviation per 1000 AA: -26.82
Total Assessments Performed: 792
EpiMatrix ReportAccession: YOUR_PROTEIN - Sequence: YOUR_PROTEIN
Maximum Single Z score
Sum of Significant Z scores
Count of Significant Z Scores
AA Sequence Hits
Summarized Results
Assessment
Hit EpiBar
EpiMatrix Immunogenicity Score
EpiMatrix Tregitope-adjusted Score
De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol. 2009 May;131(2):189-201
Comparison Data Taken From:
Wang P, Sidney J, Dow C, Mothé B, Sette A, et al. (2008) A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a
Consensus Approach. PLoS Comput Biol 4(4): e1000048. Doi:10.1371/journal.pcbi.1000048
Epitope Prediction Accuracy vs. IEDB
8
Perfect =100% Random = 50%
On average, EpiMatrix predicts T cell epitopes more accurately than IEDB.
9
Cluster Tools EpiVax - ClustiMer
DRB1*0101
DRB1*0301
DRB1*0401
DRB1*0701
DRB1*0801
DRB1*1101
DRB1*1301
DRB1*1501
• T cell epitopes are not randomly distributed throughout protein sequences but instead tend to cluster in specific regions.
– These clusters can be very powerful. One or more dominant T-cell epitope clusters can enable significant immune responses to even otherwise low scoring proteins.
• ClustiMer is used to identify T-cell epitope clusters. It identifies polypeptides predicted to bind to an unusually large number of HLA alleles.
• T-cell epitope clusters make excellent vaccine candidates:
– compact; relatively easy to deliver as peptides; highly reactive in-vivo
Non-Confidential EpiVax
Immunogenicity Scale
10
- 80 -
- 70 -
- 60 -
- 50 -
- 40 -
- 30 -
- 20 -
- 10 -
- 00 -
- -10 -
- -20 -
- -30 -
- -40 -
- -50 -
- -60 -
- -70 -
- -80 -
Thrombopoietin
Erythropoietin
IgA
Fibrinogen-Gamma
Albumin
IgG FC Region
GMCSF
Follitropin-Beta
Fibrinogen-Alpha
Beta-2-Microglobulin
Interferon-Beta
GHRH
Tetanus Toxin
Influenza-HA
Tetanus Toxin (825-850)
HCV NPC NS3 (1248-1267)
Influenza HA (306-319)
Tetanus Toxin (947-967)
Human CLIP
EBV BHRF1(171-189)
20-mer Theoretical Minimum
- +40 -
- -
- +30 -
- -
- +20 -
- -
- +10 -
- -
- 0.0 -
- -
- -10 -
Your Protein Here
Your Peptide or
Cluster Here
EpiVax has developed an immunogenicity scale to compare predicted immunogenicity across
whole proteins, clusters and antibodies. This allows for easy comparison between different
sequences of different lengths and to known compounds.
Non-Confidential EpiVax
• iTEM uses HLA-specific EpiMatrix scores to
measure potential for response to peptide antigen
Can be used to predict which patients (with which
HLA) will develop an antibody response in a
clinical trial…
. . . Immunopharmacogenomics
iTEM Analysis
Individualized T cell Epitope Measure
11
A Method for Individualizing the Prediction
of Immunogenicity of Protein Vaccines and
Biologic Therapeutics: Individualized T Cell
Epitope Measure (iTEM), Apr 2010
Non-Confidential EpiVax
Epitope can be either
effector or regulatory
Presence of Epitope Indicates Immune Potential
Mature
APC
T reg T eff
12 Non-Confidential EpiVax
What is Tregitope?
• Short, linear peptide sequences that activate regulatory T cells
• Highly conserved in IgG across species
• Tregitope role: to suppress inflammation
• Co-formulated or attached to proteins to provide antigen-specific tolerance
• Discovered and patented by Annie De Groot and Bill Martin at EpiVax
• First in class therapeutic
• Wide range of applications
De Groot A.S., et al., Activation of Natural Regulatory T cells by IgG Fc-derived Peptide
“Tregitopes”. Blood, 2008,112: 3303. http://tinyurl.com/ASDeGroot-Blood-2008
http://bit.ly/Treg1 EpiVax Non-Confidential 13
Correlation to observed Immunogenicity before accounting for Tregitopes
R2=0.17
Non-Confidential EpiVax 14
Tregitope Inclusion
Improves Prediction Accuracy
Accounting for Tregitopes results in more accurate predictions.
Correlation to observed immunogenicity after accounting for Tregitopes
R2=0.76
Tregitope Inclusion
Improves Prediction Accuracy
15
EpiVax discovered and patented sequences called Tregitopes, promiscuous T cell epitopes that
have been shown to activate regulatory T cells. In the EpiVax immunogenicity analysis the
presence of a Tregitope decreases the potential for immunogenicity.
The inclusion of Tregitopes in predictions is particularly crucial in comparing antibodies, which often contain Tregitope sequences. Non-Confidential EpiVax
Better Antibody Analysis - 80 -
- 70 -
- 60 -
- 50 -
- 40 -
- 30 -
- 20 -
- 10 -
- 00 -
- -10 -
- -20 -
- -30 -
- -40 -
- -50 -
- -60 -
- -70 -
- -80 -
IgG FC Region
Nuvion (0%)
Avastin (0%)
AB01 (EPX Adjusted Score: -46.98)
AB02 (EPX Adjusted Score: -44.48)AB03 (EPX Adjusted Score: -44.81)AB04 (EPX Adjusted Score: -45.81)AB05 (EPX Adjusted Score: -45.88)
AB06 (EPX Adjusted Score: -47.85)
AB07 (EPX Adjusted Score: -46.99)
AB08 (EPX Adjusted Score: -46.30)
AB09 (EPX Adjusted Score: -47.40)
AB10 (EPX Adjusted Score: -45.88)
AB11 (EPX Adjusted Score: -47.40)
Synagis (1%)
Simulect (1.4%)Humira (12%)
Bivatuzumab (6.7%)
Remicade (26%)
Rituxan (27%)
Campath (45%)
Humicade (7%)
Reopro (5.8%)
Tysabri (7%)
LeukArrest (0%)
Herceptin (0.1%)
New drug
Due to the presence of Tregitopes, antibodies tend to fall lower
on the immunogenicity scale.
We have developed a refined method using regression
analysis to predict the immunogenicity of antibody sequences
based on observed clinical responses.
We have found that a balance in favor of Tregitope (regulatory)
content over neo-epitope (effector) content is correlated with
reduced clinical immunogenicity.
Ne
o E
pito
pe
Co
nte
nt
Tregitope Content
High Low Low
Avastin (0%)
Herceptin (0%)
Mylotarg (3%)
Simulect (1%)
Synagis (1%)
Hig
h
Campath (45%) Remicade (26%)
Rituxan (27%)
16 Non-Confidential EpiVax
MHC
TCR
A New Way to Analyze Homology:
JanusMatrix
JanusMatrix is designed to predict the
potential for cross reactivity between epitope
clusters and the human genome, based on
conservation of TCR-facing residues in their
putative HLA ligands.
17 Non-Confidential EpiVax
HCV_G1_1605
HCV_G1_DEXDC_1246
HCV_G1_NS5A_1988
HCV_G1_NS4B_1725
HCV_G1_2898
HCV_G1_2913
HCV_G1_ENV_359
HCV_G1_2941
HCV_G1_NS4B_1910
HCV_G1_ENV_255
HCV_G1_2440
HCV_G1_NS2_732
HCV_G1_NS2_748
HCV_G1_2840
HCV_G1_1941
HCV_G1_NS4B_1769
HCV_G1_NS2_909
HCV_G1_2485
HCV_G1_NS4b_1798 HCV_G1_NS4B_1790
HCV_G1_NS4B_1876
HCV_G1_2879
All induced Teff response
Example: HCV Vaccine
22/23 epitopes vs. human proteome
18 Non-Confidential EpiVax
646897107
LRHM_1393
fibronectin-b ind ing
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644328538
HMPREF0530_2361
fibronectin
b ind ing prote in
A [Lactobacillus
paracasei ATCC
25302]
643123048
BACDOR_03958
ABC-type
multidrug
transport
system, ATPase
and permease
components
[Bacteroides
dorei DSM
17855]
643926407
Lparp8_010100002015
fibronectin-b ind ing
prote in
[Lactobacillus
paracasei
8700:2]
644392137
HMPREF0539_1504
fibronectin
b ind ing prote in
A [Lactobacillus
rhamnosus
LMS2-1]
650063005
HMPREF0864_03563
PTS protein
[Enterobacteriaceae
bacterium
9_2_54FAA]
650576916
CK1_14550
hypothetical
prote in
[Ruminococcus
sp. SR1/5]
643138141
DESPIG_00923
Glycogen
debranching
enzyme
[Desulfovibrio
piger ATCC
29098]
650018804
HMPREF1004_00251
twin-arg in ine
translocation
pathway signal
[Ralstonia sp.
5_7_47FAA]
645282591
B2_010100019185
hypothetical
prote in
[Bacteroides sp.
2_1_7]
648908601
HMPREF9008_03392
RagB/SusD
hypothetical
prote in
[Bacteroides sp.
20_3]
648889725
HMPREF0104_03558
RagB/SusD
domain-conta in ing
prote in
[Bacteroides sp.
3_1_19]
643155446
PRABACTJOHN_01075
RagB, SusD and
hypothetical
proteins.
[Parabacteroides
johnsonii DSM
18315]
646289358
HMPREF0619_03868
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
650533738
CLS_16740
TRAP
transporter,
DctM subunit
[Clostridium cf.
saccharolyticum
K10] 651551911
HMPREF9538_05675
LysR substrate
b ind ing domain
prote in
[Klebsiella sp.
MS 92-3]
647938759
HMPREF0485_01635
transcription
regulator
protein, MDR
efflux pump
cluster
[Klebsiella sp.
1_1_55]
651312886
HMPREF0240_01840
shikimate
kinase
[Clostridium sp.
D5]
650592773
CL3_32810
TRAP
transporter,
DctM subunit
[Clostridiales
sp. SM4/1]
643916645
Cbac1_010100015578
PTS system, IIB
component
[Clostridiales
sp. 1_7_47FAA]
648576449
HMPREF9541_02931
conserved
hypothetical
prote in
[Escherichia coli
MS 116-1]
643917888
Cbac1_010100021787
hypothetical
prote in
[Clostridiales
sp. 1_7_47FAA]
646213459
BSBG_01768
ABC transporter
ATP-bind ing
prote in
[Bacteroides sp.
9_1_42FAA]
647369118
EDWATA_01849
threonine-phosphate
decarboxylase
[Edwardsiella
tarda ATCC
23685]
650063271
HMPREF0864_03827
UDP-N-acetylglucosamine
d iphosphorylase/g lucosamine-1-phosphate
N-acetyltransferase
[Enterobacteriaceae
bacterium
9_2_54FAA]
644328486
HMPREF0530_2309
ATP-dependent
deoxyribonuclease,
subunit A
[Lactobacillus
paracasei ATCC
25302]
647855848
HMPREF0847_00391
hypothetical
prote in
[Streptococcus
sp. 2_1_36FAA]
644392182
HMPREF0539_1549
ATP-dependent
deoxyribonuclease,
subunit A
[Lactobacillus
rhamnosus
LMS2-1]
647369715
EDWATA_02446
integral
membrane
prote in
[Edwardsiella
tarda ATCC
23685]
646897150
LRHM_1436
ATP-dependent
exonuclease
subunit A
[Lactobacillus
rhamnosus GG,
ATCC 53103]
643926359
Lparp8_010100001765
ATP-dependent
exoDNAse
(exonuclease V)
beta subunit
[Lactobacillus
paracasei
8700:2]
651373768
HMPREF0127_04622
hypothetical
prote in
[Bacteroides sp.
1_1_30]
648881902
HMPREF9007_00606
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
1_1_14]
648892415
HMPREF0106_01939
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
D22]
647459210
CW1_1639 RNA
polymerase
sigma-70 factor
[Bacteroides
ovatus SD CC
2a]
646275464
BSIG_02296
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
1_1_6]
644270816
ROSEINA2194_02314
TrpR-related
prote in
YerC/YecD
[Roseburia
inulinivorans
DSM 16841]
651312216
HMPREF0240_01166
TrpR-like
prote in
[Clostridium sp.
D5]
651333144
HMPREF0988_02534
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651346833
HMPREF0993_02418
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
650583643
RTO_16000
TrpR-related
prote in
YerC/YecD
[Ruminococcus
torques L2-14]
651366495
HMPREF1025_00393
TrpR protein
YerC/YecD
[Lachnospiraceae
bacterium
3_1_46FAA]
650577568
CK1_22230
TrpR-related
prote in
YerC/YecD
[Ruminococcus
sp. SR1/5]
650567742
ROI_38070
TrpR-related
prote in
YerC/YecD
[Roseburia
intestinalis
M 50/1]
651343264
HMPREF0994_05806
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650570318
RO1_26580
TrpR-related
prote in
YerC/YecD
[Roseburia
intestinalis
XB6B4]
644156939
RUMHYD_02612
TrpR-related
prote in
YerC/YecD
[Blautia
hydrogenotrophica
DSM 10507]
651328108
HMPREF0990_00344
TrpR protein
YerC/YecD
[Lachnospiraceae
bacterium
1_1_57FAA]
650580572
CK5_17800
TrpR-related
prote in
YerC/YecD
[Ruminococcus
obeum A2-162]
650047371
HMPREF1026_00070
TrpR/YerC/YecD
prote in
[Lachnospiraceae
bacterium sp.
8_1_57FAA] 643112515
CLONEX_00021
TrpR-related
prote in
YerC/YecD
[Clostridium
nexile DSM
1787]
650538389
CC1_32850
TrpR-related
prote in
YerC/YecD
[Coprococcus
catus GD/7]
644101358
COPCOM_01077
TrpR-related
prote in
YerC/YecD
[Coprococcus
comes ATCC
27758]
651337064
HMPREF0991_03195
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650042220
HMPREF1016_01813
dolichyl-phosphate-mannose-prote in
mannosyltransferase
[Bacteroides
eggerthii
1_2_48FAA]
650528931
BIL_14850
hypothetical
prote in
[Bifidobacterium
longum longum
F8]
647513128
HMPREF0493_1391
cytidylate
kinase
[Lactobacillus
amylolyticus
DSM 11664]
644165764
BACCELL_00927
4-amino-4-deoxy-L-arabinose
transferase and
related
glycosyltransferases
of PMT family
[Bacteroides
cellulosilyticus
DSM 14838]
644284103
HMPREF0496_0349
adenylylsulfate
reductase
[Lactobacillus
brevis
gravesensis
ATCC 27305]
651542515
HMPREF9446_00260
dolichyl-phosphate-mannose-prote in
mannosyltransferase
[Bacteroides
fluxus YIT
12057]
644158474
HOLDEFILI_00216
Predicted
transcriptional
regulators
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
646262918
HRAG_00601
thymidylate
kinase
[Helicobacter
bilis ATCC
43879] 643140215
DESPIG_02998
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Desulfovibrio
piger ATCC
29098]
643145692
PROVALCAL_01369
Transcriptional
regulator
[Providencia
alcalifaciens
DSM 30120]
648927374
HMPREF0326_02088
type VI
secretion
prote in ,
VC_A0114
family
[Desulfovibrio
sp. 3_1_syn3]
651541957
HMPREF9445_03033
dolichyl-phosphate-mannose-prote in
mannosyltransferase
[Bacteroides
clarus YIT
12056]
643095437
BACEGG_00204
4-amino-4-deoxy-L-arabinose
transferase and
related
glycosyltransferases
of PMT family
[Bacteroides
eggerthii DSM
20697]
650569022
RO1_11940
hypothetical
prote in
[Roseburia
intestinalis
XB6B4]
650087839
HMPREF9464_01029
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
644159799
HOLDEFILI_01543
hypothetical
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
651361870
HMPREF1018_00744
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
651383622
HMPREF9477_00885
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA] 646269512
BSHG_00932
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
651312463
HMPREF0240_01414
AMP-dependent
synthetase and
ligase
[Clostridium sp.
D5]
644160607
HOLDEFILI_02351
Na -driven
multidrug efflux
pump
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
647885571
HMPREF0101_02623
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
651567871
HMPREF9413_2216
Beta-eliminating
lyase
[Paenibacillus
sp. HGF7]
650538330
CC1_32230
ATPase, P-type
(transporting),
HAD
superfamily,
subfamily IC
[Coprococcus
catus GD/7]
650045277
HMPREF1023_00949
luxR family
Bacterial
regulatory
prote in
[Eggerthella sp.
1_3_56FAA]
643925771
HpulM9_010100009425
thymidylate
kinase
[Helicobacter
pullorum MIT
98-5489]
643140200
DESPIG_02983
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
650571179
RO1_37110
tRNA(Ile)-lysidine
synthetase,
N-terminal
domain/tRNA(Ile)-lysidine
synthetase,
C-terminal
domain
[Roseburia
intestinalis
XB6B4]
646006646
BacD2_010100019909
hypothetical
prote in
[Bacteroides sp.
D2]
651516796
HMPREF9412_0783
Beta-eliminating
lyase
[Paenibacillus
sp. HGF5] 646224770
BSCG_03288
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
647880008
HMPREF0102_01882
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
647460066
CW1_4644
conserved
domain prote in
[Bacteroides
ovatus SD CC
2a]
646219274
BSAG_02634
conserved
hypothetical
prote in
[Bacteroides sp.
D1]
648905787
HMPREF9010_03609
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_23]
647442302
CW3_4406
conserved
domain prote in
[Bacteroides
xylanisolvens
SD CC 1b]
647455517
CUY_1326
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
648890757
HMPREF0106_00282
hypothetical
prote in
[Bacteroides sp.
D22]
648564978
HMPREF9530_02421
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 21-1]
648597116
HMPREF9549_02183
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 185-1]
648552428
HMPREF9534_00065
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 69-1]
648547530
HMPREF9531_00512
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 45-1]
650543286
ENC_32680
ABC-type Fe3
-siderophore
transport
system,
permease
component
[Enterobacter
cloacae cloacae
NCTC 9394]
646207500
ESAG_01227
iron ABC
transporter
permease
[Escherichia sp.
3_2_53FAA]
648588094
HMPREF9553_04319
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 200-1]
648590015
HMPREF9551_00793
iron chelate
uptake ABC
transporter,
FeCT family,
permease
prote in
[Escherichia coli
MS 196-1]
646243637
CSAG_00020
predicted
prote in
[Citrobacter sp.
30_2]
650087745
HMPREF9464_00950
crp/Fnr family
Transcriptional
regulator
[Sutterella
wadsworthensis
3_1_45B]
650539665
CCU_15010
hypothetical
prote in
[Coprococcus
sp. ART55/1]
650013489
HMPREF0983_02062
putative
diarrheal toxin
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650320841
HMPREF9420_2035
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
651572855
HMPREF9413_5814
arylsulfatase
[Paenibacillus
sp. HGF7]
650045118
HMPREF1023_00790
luxR family
Bacterial
regulatory
prote in
[Eggerthella sp.
1_3_56FAA]
650061657
HMPREF0864_02232
alpha amylase
[Enterobacteriaceae
bacterium
9_2_54FAA]
650352274
HMPREF9443_02055
CRISPR-associated
protein, Csn1
family
[Phascolarctobacterium
sp. YIT 12067]
644226848
EUBHAL_01293
Phosphate
starvation-inducib le
protein PhoH,
predicted
ATPase
[Eubacterium
hallii DSM 3353]
651360094
HMPREF1017_04090
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
646224828
BSCG_03346
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
646259551
OFAG_01507
chaperone SurA
[Oxalobacter
formigenes
HOxBLS]
647449747
CUW_1263 DNA
topoisomerase
IV, A subunit
[Turicibacter
sanguinis
PC909]
648587459
HMPREF9553_03683
hypothetical
prote in
[Escherichia coli
MS 200-1]
644097630
PROPEN_02340
AAA domain
(Cdc48
subfamily).
[Proteus penneri
ATCC 35198]
646247184
CSAG_03511
Sua5/YciO/YrdC/YwlC
family protein
[Citrobacter sp.
30_2]
643139396
DESPIG_02179
Outer
membrane
prote in
(OmpH-like).
[Desulfovibrio
piger ATCC
29098]
650088265
HMPREF9464_01439
flp p ilus
assembly
prote in
[Sutterella
wadsworthensis
3_1_45B]
644270805
ROSEINA2194_02303
Serine/threonine
protein kinase
[Roseburia
inulinivorans
DSM 16841]
646035840
ChatD1_010100007516
hypothetical
prote in
[Clostridium
hathewayi DSM
13479]
650598591
CK3_33190
TrpR-related
prote in
YerC/YecD
[Clostridiales
sp. SS3/4]
644177756
CLOSTASPAR_02371
TrpR-related
prote in
YerC/YecD
[Clostridium
asparagiforme
DSM 15981] 651517389
HMPREF9412_5440
transcriptional
regulator, LuxR
family
[Paenibacillus
sp. HGF5]
643917094
Cbac1_010100017829
TrpR like
prote in ,
YerC/YecD
[Clostridiales
sp. 1_7_47FAA] 651678006
HMPREF9418_0568
transcriptional
regulator Anr
[Neisseria
macacae ATCC
33926]
646304999
HMPREF0026_02442
primosomal
protein N
[Acinetobacter
junii SH205]
643098504
BACEGG_03273
Mg-dependent
DNase
[Bacteroides
eggerthii DSM
20697]
650537523
CC1_22940
Uncharacterized
conserved
protein (some
members
contain a von
Willebrand
factor type A
(vWA) domain)
[Coprococcus
catus GD/7]
650041378
HMPREF1016_00978
Mg-dependent
DNase
[Bacteroides
eggerthii
1_2_48FAA]
648688861
HMPREF9521_00708
histidine kinase
[Enterococcus
faecalis
TX2134]
647988365
HMPREF0874_00617
methylmalonyl-CoA
epimerase
[Veillonella sp.
6_1_27]
644294383
HMPREF0348_1204
possible
histidine kinase
[Enterococcus
faecalis
TX0104]
650588611
ENT_26790
Signal
transduction
histidine kinase
[Enterococcus
sp. 7L76]
645347505
ShiD9_010100016841
cell wall
shape-determin ing
protein [Shigella
sp. D9]
648572234
HMPREF9535_03818
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 78-1]
648531274
HMPREF9536_05721
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 84-1]
651549390
HMPREF9538_03152
rod
shape-determin ing
protein RodA
[Klebsiella sp.
MS 92-3]
648541752
HMPREF9548_05239
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 182-1]
648577976
HMPREF9541_04458
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 116-1]
648556685
HMPREF9534_04323
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 69-1] 648535600
HMPREF9540_04218
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 115-1]
648598735
HMPREF9549_03804
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 185-1]
646206839
ESAG_00573
rod
shape-determin ing
protein RodA
[Escherichia sp.
3_2_53FAA]
648927142
HMPREF0326_01859
RNA
modification
enzyme,
MiaB-family
[Desulfovibrio
sp. 3_1_syn3]
646261147
OFBG_00955
FAD/FMN-containing
dehydrogenase
[Oxalobacter
formigenes
OXCC13]
644209508
CLOSTMETH_03465
Predicted Zn
peptidase
[Clostridium
methylpentosum
R2, DSM 5476]
646265889
HWAG_01253
conserved
hypothetical
prote in
[Helicobacter
winghamensis
ATCC BAA-430]
650351527
HMPREF9443_01307
L-asparaginase
[Phascolarctobacterium
sp. YIT 12067]
643124383
ANHYDRO_00256
Cna protein
B-type domain.
[Anaerococcus
hydrogenalis
DSM 7454]
644098715
PROPEN_03428
translation
factor SUA5
[Proteus penneri
ATCC 35198]
651546256
HMPREF9538_00017
negative
regulator of
genetic
competence
ClpC/MecB
[Klebsiella sp.
MS 92-3]
651337471
HMPREF0994_00057
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
647986504
HMPREF0873_00628
methylmalonyl-CoA
epimerase
[Veillonella sp.
3_1_44]
648531805
HMPREF9540_00421
ATPase family
prote in
[Escherichia coli
MS 115-1]
650020839
HMPREF1004_02304
ATP-dependent
Clp protease,
ATP-bind ing
subunit ClpC
[Ralstonia sp.
5_7_47FAA]
650319738
HMPREF9420_0951
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
651342555
HMPREF0994_05103
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
648534834
HMPREF9540_03452
ATPase family
prote in
[Escherichia coli
MS 115-1]
646266598
ESCG_01087
ATPase with
chaperone
activity
[Escherichia sp.
1_1_43]
648583660
HMPREF9547_04869
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 175-1]
648551221
HMPREF9531_04206
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 45-1]
645350729
E4_010100010287
cell wall
shape-determin ing
prote in
[Escherichia sp.
4_1_40B]
648588765
HMPREF9553_04990
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 200-1]
647939288
HMPREF0485_02161
rod
shape-determin ing
protein RodA
[Klebsiella sp.
1_1_55]
648593936
HMPREF9551_04716
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 196-1]
648561740
HMPREF9550_03789
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 187-1]
648565362
HMPREF9530_02805
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 21-1]
646244048
CSAG_00429
cell wall
shape-determin ing
prote in
[Citrobacter sp.
30_2]
648524970
HMPREF9552_05139
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 198-1]
644160019
HOLDEFILI_01763
Predicted
transcriptional
regulators
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
643922089
HcinC1_010100003150
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
647371096
EDWATA_03829
dipeptide ABC
transporter,
ATP-bind ing
protein DppD
[Edwardsiella
tarda ATCC
23685]
650021631
HMPREF1004_03094
DNA
polymerase III
subunit alpha
[Ralstonia sp.
5_7_47FAA]
647513266
HMPREF0493_1501
hypothetical
prote in
[Lactobacillus
amylolyticus
DSM 11664]
646896283
LRHM_0608
putative
multidrug ABC
transporter
ATP-bind ing
component
[Lactobacillus
rhamnosus GG,
ATCC 53103]
650062929
HMPREF0864_03487
yrdC
domain-conta in ing
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
648926945
HMPREF0326_01668
4-(cytid ine
5 '-d iphospho)-2-C-methyl-D-erythr ito l
kinase
[Desulfovibrio
sp. 3_1_syn3]
644316707
HMPREF0545_1139
ribonuclease HI
[Lactobacillus
salivarius
HO66, ATCC
11741]
650012947
HMPREF0983_01497
putative
aspartate
aminotransferase
[Erysipelotrichaceae
bacterium sp.
3_1_53]
644102280
COPCOM_02000
Transcriptional
regulators
[Coprococcus
comes ATCC
27758]
643147789
PROVALCAL_03476
Predicted
membrane
prote in
[Providencia
alcalifaciens
DSM 30120]
647857524
HMPREF0847_02056
ATP-bind ing
transporter
ComA
[Streptococcus
sp. 2_1_36FAA]
650073316
HMPREF9488_01292
ABC transporter
[Coprobacillus
sp. 29_1]
650565850
ROI_15910
tRNA(Ile)-lysidine
synthetase,
N-terminal
domain/tRNA(Ile)-lysidine
synthetase,
C-terminal
domain
[Roseburia
intestinalis
M 50/1]
643116437
CLONEX_03946
ABC-type
n itra te/su lfonate/b icarbonate
transport
system, ATPase
component
[Clostridium
nexile DSM
1787]
643139916
DESPIG_02699
GTP
cyclohydrolase
subunit MoaA
[Desulfovibrio
piger ATCC
29098]
651516013
HMPREF9412_5193
transcriptional
regulator, AraC
family
[Paenibacillus
sp. HGF5]
644143876
BACCOPRO_00205
Uncharacterized
conserved
prote in
[Bacteroides
coprophilus
DSM 18228]
651367701
HMPREF1025_01578
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
643928977
Lparp8_010100014860
tetracycline
resistance
structural
protein TetA
[Lactobacillus
paracasei
8700:2]
644095308
PROPEN_00011
Arabinose efflux
permease
[Proteus penneri
ATCC 35198]
643113002
CLONEX_00508
Arabinose efflux
permease
[Clostridium
nexile DSM
1787]
648520000
HMPREF9552_00166
transporter,
major facilitator
family protein
[Escherichia coli
MS 198-1]
643923830
HcinC1_010100012020
tetracycline
resistance
structural
protein TetA
[Helicobacter
cinaedi CCUG
18818]
643137611
DESPIG_00391
Arabinose efflux
permease
[Desulfovibrio
piger ATCC
29098]
643158899
PRABACTJOHN_04529
Arabinose efflux
permease
[Parabacteroides
johnsonii DSM
18315]
648579514
HMPREF9547_00720
transporter,
major facilitator
family protein
[Escherichia coli
MS 175-1]
643919673
Cbac1_010100030692
tetracycline
resistance
structural
protein TetA
[Clostridiales
sp. 1_7_47FAA]
643147537
PROVALCAL_03223
Predicted
membrane
prote in
[Providencia
alcalifaciens
DSM 30120]
650060234
HMPREF0864_00824
sulfatase
[Enterobacteriaceae
bacterium
9_2_54FAA]
650353954
HMPREF9444_01560
conserved
domain prote in
[Succinatimonas
hippei YIT
12066]
646272574
BSHG_03947
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
650008741
HMPREF1007_00969
hypothetical
prote in
[Bacteroides sp.
4_1_36]
650560164
FPR_30930
Restriction
endonuclease S
subunits
[Faecalibacterium
prausnitzii
SL3/3]
650087089
HMPREF9464_00302
polar amino
acid ABC
transporter
[Sutterella
wadsworthensis
3_1_45B]
648534633
HMPREF9540_03250
peptidase, M48
family
[Escherichia coli
MS 115-1]
646227427
BSCG_05908
tetracycline
resistance
prote in
[Bacteroides sp.
2_2_4]
646216467
BSBG_04744
tetracycline
resistance
prote in
[Bacteroides sp.
9_1_42FAA]
648545499
HMPREF9543_03552
transporter,
major facilitator
family protein
[Escherichia coli
MS 146-1]
643911330
BbifN4_010100009360
tetracycline
resistance
structural
protein TetA
[Bifidobacterium
bifidum NCIMB
41171]
645283147
B2_010100021971
tetracycline
resistance
prote in
[Bacteroides sp.
2_1_7]
643913320
BloniC5_010100009852
tetracycline
resistance
structural
protein TetA
[Bifidobacterium
longum longum
CCUG 52486]
644288259
HMPREF0497_1383
conserved
hypothetical
prote in
[Lactobacillus
buchneri ATCC
11577] 648538536
HMPREF9548_02020
transporter,
major facilitator
family protein
[Escherichia coli
MS 182-1]
644100297
COPCOM_00016
Arabinose efflux
permease
[Coprococcus
comes ATCC
27758]
646228165
BSEG_00669
ABC transporter
ATP-bind ing
prote in
[Bacteroides
dore i
5_1_36/D4]
644286383
HMPREF0496_2581
conserved
hypothetical
prote in
[Lactobacillus
brevis
gravesensis
ATCC 27305]
651363233
HMPREF1018_02096
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
646240811
MBAG_00648
predicted
prote in
[Coprobacillus
sp. D7]
647893735
HMPREF9024_01405
transcription
accessory
prote in
[Pediococcus
acidilactici 7_4]
644156633
RUMHYD_02306
Pyruvate:ferredoxin
oxidoreductase
and related
2-oxoacid:ferredoxin
oxidoreductases,
gamma subunit
[Blautia
hydrogenotrophica
DSM 10507]
650198262
HMPREF0623_0974
YhgF like
prote in
[Pediococcus
acidilactici DSM
20284]
647457612
CW1_2658
efflux ABC
transporter,
permease
prote in
[Bacteroides
ovatus SD CC
2a]
645345968
ShiD9_010100009122
hypothetical
protein [Shigella
sp. D9]
646267454
ESCG_00515
conserved
hypothetical
prote in
[Escherichia sp.
1_1_43]
648588066
HMPREF9553_04291
hypothetical
prote in
[Escherichia coli
MS 200-1]
651357900
HMPREF1017_01928
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
648597143
HMPREF9549_02210
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
648538381
HMPREF9548_01865
hypothetical
prote in
[Escherichia coli
MS 182-1]
646207525
ESAG_01252
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
647456123
CW1_3815
efflux
transporter,
outer
membrane
factor
lipoprote in ,
NodT family
[Bacteroides
ovatus SD CC
2a]
648582903
HMPREF9547_04111
hypothetical
prote in
[Escherichia coli
MS 175-1]
651369358
HMPREF0127_00262
hypothetical
prote in
[Bacteroides sp.
1_1_30]
648529403
HMPREF9536_03850
hypothetical
prote in
[Escherichia coli
MS 84-1]
651373678
HMPREF0127_04532
hypothetical
prote in
[Bacteroides sp.
1_1_30]
648589991
HMPREF9551_00769
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
648569110
HMPREF9535_00693
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
646895903
LRHM_0232
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644328023
HMPREF0530_1852
conserved
hypothetical
prote in
[Lactobacillus
paracasei ATCC
25302]
643927741
Lparp8_010100008715
Predicted
membrane
prote in
[Lactobacillus
paracasei
8700:2]
647856891
HMPREF0847_01428
GNAT family
acetyltransferase
[Streptococcus
sp. 2_1_36FAA]
644391441
HMPREF0539_0815
permease
[Lactobacillus
rhamnosus
LMS2-1]
644390750
HMPREF0539_0126
permease
[Lactobacillus
rhamnosus
LMS2-1]
647453271
CUY_5065
efflux
transporter,
outer
membrane
factor
lipoprote in ,
NodT family
[Bacteroides
ovatus SD CMC
3f]
646227380
BSCG_05865
outer
membrane
efflux prote in
oprM
[Bacteroides sp.
2_2_4]
648903495
HMPREF9010_01082
outer
membrane
efflux prote in
OprM
[Bacteroides sp.
3_1_23]
648894940
HMPREF0106_04483
outer
membrane
efflux prote in
OprM
[Bacteroides sp.
D22]
646220831
BSAG_04177
outer
membrane
efflux prote in
oprM
[Bacteroides sp.
D1]
646007548
BacD2_010100024426
outer
membrane
efflux prote in
oprM precursor
[Bacteroides sp.
D2]
647879744
HMPREF0102_01619
outer
membrane
efflux prote in
oprM
[Bacteroides sp.
2_1_22]
647442660
CW3_4757
efflux
transporter,
outer
membrane
factor
lipoprote in ,
NodT family
[Bacteroides
xylanisolvens
SD CC 1b]
648562067
HMPREF9550_04116
conserved
hypothetical
prote in
[Escherichia coli
MS 187-1]
645351388
E4_010100013599
hypothetical
prote in
[Escherichia sp.
4_1_40B] 648547556
HMPREF9531_00538
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
648532122
HMPREF9540_00738
conserved
hypothetical
prote in
[Escherichia coli
MS 115-1]
648525212
HMPREF9552_05381
conserved
hypothetical
prote in
[Escherichia coli
MS 198-1]
648577642
HMPREF9541_04124
conserved
hypothetical
prote in
[Escherichia coli
MS 116-1]
648552447
HMPREF9534_00084
conserved
hypothetical
prote in
[Escherichia coli
MS 69-1]
648564996
HMPREF9530_02439
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
648585757
HMPREF9553_01980
hypothetical
prote in
[Escherichia coli
MS 200-1]
648532850
HMPREF9540_01467
conserved
hypothetical
prote in
[Escherichia coli
MS 115-1]
648528279
HMPREF9536_02724
hypothetical
prote in
[Escherichia coli
MS 84-1]
648570808
HMPREF9535_02392
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
648583178
HMPREF9547_04386
hypothetical
prote in
[Escherichia coli
MS 175-1]
647941767
HMPREF0485_04604
yeaL [Klebsiella
sp. 1_1_55] 648578226
HMPREF9541_04708
conserved
hypothetical
prote in
[Escherichia coli
MS 116-1]
645344919
ShiD9_010100003853
conserved inner
membrane
protein [Shigella
sp. D9]
651552290
HMPREF9538_06054
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
646244643
CSAG_01006
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
648590236
HMPREF9551_01014
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
648542647
HMPREF9543_00699
conserved
hypothetical
prote in
[Escherichia coli
MS 146-1]
648557349
HMPREF9534_04988
conserved
hypothetical
prote in
[Escherichia coli
MS 69-1]
645349504
E4_010100004179
conserved inner
membrane
prote in
[Escherichia sp.
4_1_40B]
647456249
CW1_1394
response
regulator
receiver domain
prote in
[Bacteroides
ovatus SD CC
2a]
646225070
BSCG_03588
two-component
system sensor
histidine
kinase/response
regulator
[Bacteroides sp.
2_2_4]
646004545
BacD2_010100009346
two-component
system sensor
histidine
kinase/response
regulator,
hybrid
('one-component
system')
[Bacteroides sp.
D2]
647442704
CW3_1134
response
regulator
receiver domain
prote in
[Bacteroides
xylanisolvens
SD CC 1b]
647453329
CUY_0572
response
regulator
receiver domain
prote in
[Bacteroides
ovatus SD CMC
3f]
648905375
HMPREF9010_04162
two-component
system sensor
histidine
kinase/response
regulator,
hybrid
(one-component
system)
[Bacteroides sp.
3_1_23]
651358611
HMPREF1017_02631
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
643119573
BACDOR_00482
Uncharacterized
prote in
conserved in
bacteria
[Bacteroides
dorei DSM
17855]
646218672
BSAG_02040
two-component
system sensor
histidine
kinase/response
regulator
[Bacteroides sp.
D1]
647878135
HMPREF0102_00037
two-component
system sensor
histidine
kinase/response
regulator
[Bacteroides sp.
2_1_22]
648599701
HMPREF9549_04771
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
646208752
ESAG_02468
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648552154
HMPREF9531_05139
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
648522984
HMPREF9552_03152
conserved
hypothetical
prote in
[Escherichia coli
MS 198-1]
648566267
HMPREF9530_03710
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
648558944
HMPREF9550_00991
conserved
hypothetical
prote in
[Escherichia coli
MS 187-1]
648539477
HMPREF9548_02962
hypothetical
prote in
[Escherichia coli
MS 182-1]
646209587
ESAG_03285
su lfa te/th iosulfa te
transporter
subunit CysT
[Escherichia sp.
3_2_53FAA]
648572039
HMPREF9535_03623
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 78-1]
648600222
HMPREF9549_05292
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 185-1]
648546527
HMPREF9543_04581
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 146-1]
643145990
PROVALCAL_01668
sulfate ABC
transporter,
permease
protein CysT
[Providencia
alcalifaciens
DSM 30120]
646245885
CSAG_02233
su lfa te/th iosulfa te
transporter
subunit CysT
[Citrobacter sp.
30_2]
645344307
ShiD9_010100000825
su lfa te/th iosulfa te
transporter
subunit
[Shigella sp. D9]
650059859
HMPREF0864_00463
sulfate ABC
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
648543645
HMPREF9543_01698
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 146-1]
648521295
HMPREF9552_01462
conserved
domain prote in
[Escherichia coli
MS 198-1]
648555205
HMPREF9534_02842
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 69-1]
648578693
HMPREF9541_05175
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 116-1]
648591303
HMPREF9551_02082
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 196-1]
648595378
HMPREF9549_00444
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 185-1]
648526848
HMPREF9536_01291
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 84-1]
648567644
HMPREF9530_05088
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 21-1]
647937242
HMPREF0485_00139
sulfate ABC
transporter,
permease CysT
[Klebsiella sp.
1_1_55] 648589103
HMPREF9553_05328
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 200-1]
645348824
E4_010100000800
su lfa te/th iosulfa te
transporter
subunit
[Escherichia sp.
4_1_40B]
651551663
HMPREF9538_05427
sulfate ABC
transporter,
permease
protein CysT
[Klebsiella sp.
MS 92-3]
648536354
HMPREF9540_04974
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 115-1]
648536927
HMPREF9548_00411
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 182-1]
648549444
HMPREF9531_02427
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 45-1]
648558895
HMPREF9550_00942
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 187-1]
648581795
HMPREF9547_03002
sulfate ABC
transporter,
permease
protein CysT
[Escherichia coli
MS 175-1]
647882180
HMPREF0102_04029
ABC transporter
permease
[Bacteroides sp.
2_1_22] 648904642
HMPREF9010_02237
ABC transporter
permease
[Bacteroides sp.
3_1_23]
646218952
BSAG_02315
ABC transporter
permease
[Bacteroides sp.
D1] 648894402
HMPREF0106_03941
ABC transporter
permease
[Bacteroides sp.
D22]
647441067
CW3_3396
efflux ABC
transporter,
permease
prote in
[Bacteroides
xylanisolvens
SD CC 1b]
646006126
BacD2_010100017240
ABC transporter
permease
[Bacteroides sp.
D2]
651540529
HMPREF9445_01605
efflux ABC
transporter,
permease
prote in
[Bacteroides
clarus YIT
12056]
647454327
CUY_0145
efflux ABC
transporter,
permease
prote in
[Bacteroides
ovatus SD CMC
3f]
651373142
HMPREF0127_04005
hypothetical
prote in
[Bacteroides sp.
1_1_30]
644103941
COPCOM_03663
hypothetical
prote in
[Coprococcus
comes ATCC
27758]
646231370
BSEG_03838
carbohydrate
esterase family
12 prote in
[Bacteroides
dore i
5_1_36/D4]
647437567
CUU_2038
GDSL-like
prote in
[Bacteroides
vulgatus PC510] 647530872
HMPREF0219_2871
ABC superfamily
ATP binding
cassette
transporter
superfamily
prote in
[Clostridium
difficile NAP07]
644271963
ROSEINA2194_03461
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
647888687
HMPREF0105_1086
carbohydrate
esterase family
12 prote in
[Bacteroides sp.
3_1_33FAA]
650005282
HMPREF9011_03782
hypothetical
prote in
[Bacteroides sp.
3_1_40A] 643122470
BACDOR_03380
Predicted
xylanase/chitin
deacetylase
[Bacteroides
dorei DSM
17855]
647940528
HMPREF0485_03374
oxaloacetate
decarboxylase,
beta subunit
[Klebsiella sp.
1_1_55]
648882423
HMPREF9007_01172
hypothetical
prote in
[Bacteroides sp.
1_1_14]
647510160
HMPREF0220_2248
ABC superfamily
ATP binding
cassette
transporter
superfamily
prote in
[Clostridium
difficile NAP08]
647876401
HMPREF0103_2298
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
645280677
B2_010100009578
putative 2',
3 '-cyclic
nucleotide
2'-phosphodiesterase
[Bacteroides sp.
2_1_7]
646221796
BSCG_00343
ABC transporter
permease
[Bacteroides sp.
2_2_4]
646288901
HMPREF0619_03414
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
648909135
HMPREF9008_02106
5'-nucleotidase
family protein
[Bacteroides sp.
20_3]
647455213
CUY_4106
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
648888683
HMPREF0104_02520
5'-nucleotidase
family protein
[Bacteroides sp.
3_1_19]
651359502
HMPREF1017_03509
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
645278865
B2_010100000532
putative
endonuclease/exonuclease/phosphatase
family protein
[Bacteroides sp.
2_1_7]
647938774
HMPREF0485_01650
transcription
regulatory
protein opdE
[Klebsiella sp.
1_1_55]
646222275
BSCG_00818
peptidase
[Bacteroides sp.
2_2_4]
650010945
HMPREF1007_03145
hypothetical
prote in
[Bacteroides sp.
4_1_36]
644391106
HMPREF0539_0481
xre family
transcriptional
regulator
[Lactobacillus
rhamnosus
LMS2-1]
650596784
CK3_12330
Uncharacterized
MobA-re la ted
prote in
[Clostridiales
sp. SS3/4]
647896910
HMPREF0969_00842
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
648539013
HMPREF9548_02498
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 182-1]
646209840
ESAG_03538
formate-dependent
nitrite reductase
[Escherichia sp.
3_2_53FAA] 645346635
ShiD9_010100012465
formate-dependent
nitrite reductase
complex
subunit NrfF
[Shigella sp. D9]
648529913
HMPREF9536_04360
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 84-1]
645351940
E4_010100016373
formate-dependent
nitrite reductase
complex
subunit NrfF
[Escherichia sp.
4_1_40B]
646266352
ESCG_00846
conserved
hypothetical
prote in
[Escherichia sp.
1_1_43]
648532193
HMPREF9540_00809
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 115-1]
648560726
HMPREF9550_02773
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 187-1]
648547681
HMPREF9531_00663
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 45-1]
648573260
HMPREF9535_04845
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 78-1]
648589640
HMPREF9551_00418
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 196-1]
648582054
HMPREF9547_03262
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 175-1]
648585326
HMPREF9553_01549
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 200-1]
648573823
HMPREF9541_00303
cytochrome C
biogenesis
prote in
[Escherichia coli
MS 116-1]
650543885
ENC_40020
hypothetical
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
650590255
ES1_16010 ATP
synthase
subunit C.
[Eubacterium
siraeum
V10Sc8a] 651550612
HMPREF9538_04375
transporter,
small
conductance
mechanosensitive
ion channel
MscS family
prote in
[Klebsiella sp.
MS 92-3]
646898472
LRHM_2731
transcriptional
regulator
[Lactobacillus
rhamnosus GG,
ATCC 53103]
648585077
HMPREF9553_01300
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 200-1]
648527680
HMPREF9536_02124
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 84-1]
648567341
HMPREF9530_04785
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 21-1]
645353128
E4_010100022326
guanosine
pentaphosphate
phosphohydrolase
[Escherichia sp.
4_1_40B]
648560308
HMPREF9550_02355
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 187-1]
648524543
HMPREF9552_04712
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 198-1] 648550453
HMPREF9531_03437
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 45-1]
648574481
HMPREF9541_00961
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 116-1]
648554706
HMPREF9534_02343
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 69-1]
648544703
HMPREF9543_02756
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 146-1]
648579916
HMPREF9547_01122
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 175-1]
648536501
HMPREF9540_05121
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 115-1]
648596347
HMPREF9549_01414
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 185-1]
645348414
ShiD9_010100021332
guanosine
pentaphosphate
phosphohydrolase
[Shigella sp. D9]
646268262
ESCG_02094
guanosine-5 '-triphosphate,3 '-d iphosphate
pyrophosphatase
[Escherichia sp.
1_1_43]
648594024
HMPREF9551_04804
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 196-1]
648538001
HMPREF9548_01485
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 182-1]
646211240
ESAG_04930
guanosine-5 '-triphosphate,3 '-d iphosphate
pyrophosphatase
[Escherichia sp.
3_2_53FAA]
648568952
HMPREF9535_00535
Ppx/GppA
phosphatase
family protein
[Escherichia coli
MS 78-1]
648593289
HMPREF9551_04069
n itrite
transporter
[Escherichia coli
MS 196-1]
648545466
HMPREF9543_03519
n itrite
transporter
[Escherichia coli
MS 146-1]
648523666
HMPREF9552_03834
n itrite
transporter
[Escherichia coli
MS 198-1]
648580565
HMPREF9547_01772
n itrite
transporter
[Escherichia coli
MS 175-1]
648556756
HMPREF9534_04394
n itrite
transporter
[Escherichia coli
MS 69-1]
645350063
E4_010100006994
n itra te/n itrite
transporter
[Escherichia sp.
4_1_40B]
644102766
COPCOM_02487
electron
transport
complex,
RnfABCDGE
type, D subunit
[Coprococcus
comes ATCC
27758]
651383456
HMPREF9477_00720
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
651349687
HMPREF0992_01853
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
651328774
HMPREF0990_00997
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
651330706
HMPREF0988_00134
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651335340
HMPREF0991_01506
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA] 650047805
HMPREF1026_00500
Na-translocating
NADH-quinone
reductase
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651368271
HMPREF1025_02141
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
646208194
ESAG_01916
n itrite extrusion
prote in 1
[Escherichia sp.
3_2_53FAA]
648588549
HMPREF9553_04774
n itrite
transporter
[Escherichia coli
MS 200-1]
648570380
HMPREF9535_01964
n itrite
transporter
[Escherichia coli
MS 78-1]
648578787
HMPREF9541_05269
n itrite
transporter
[Escherichia coli
MS 116-1]
648541116
HMPREF9548_04602
n itrite
transporter
[Escherichia coli
MS 182-1] 648530378
HMPREF9536_04825
n itrite
transporter
[Escherichia coli
MS 84-1]
648547244
HMPREF9531_00226
n itrite
transporter
[Escherichia coli
MS 45-1]
648595901
HMPREF9549_00967
n itrite
transporter
[Escherichia coli
MS 185-1]
648558056
HMPREF9550_00103
n itrite
transporter
[Escherichia coli
MS 187-1]
648566899
HMPREF9530_04343
n itrite
transporter
[Escherichia coli
MS 21-1]
645345425
ShiD9_010100006402
n itra te/n itrite
transporter
[Shigella sp. D9]
648584330
HMPREF9553_00553
hypothetical
prote in
[Escherichia coli
MS 200-1]
651334690
HMPREF0991_00859
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
648530292
HMPREF9536_04739
hypothetical
prote in
[Escherichia coli
MS 84-1]
643147786
PROVALCAL_03473
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Providencia
alcalifaciens
DSM 30120]
647442144
CW3_0806
conserved
hypothetical
prote in
[Bacteroides
xylanisolvens
SD CC 1b]
647450958
CUY_4616
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
648892251
HMPREF0106_01775
conserved
hypothetical
prote in
[Bacteroides sp.
D22]
651369650
HMPREF0127_00550
hypothetical
prote in
[Bacteroides sp.
1_1_30]
646223825
BSCG_02356
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
644180003
CLOSTASPAR_04620
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
asparagiforme
DSM 15981]
650188158
HMPREF9436_01896
putative KDP
operon
transcriptional
regulatory
protein KdpE
[Faecalibacterium
cf. prausnitzii
KLE1255]
650027072
HMPREF1011_00516
response
regulator
receiver
domain-conta in ing
prote in
[Anaerostipes
sp. 3_2_56FAA]
650556253
FP2_19490
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Faecalibacterium
prausnitzii
L2-6]
643184261
EUBIFOR_01499
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
biforme DSM
3989]
650559857
FPR_27460
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Faecalibacterium
prausnitzii
SL3/3]
644158263
HOLDEFILI_00005
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650562669
MHY_04970
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Megamonas
hypermegale
ART12/1]
646241223
MBAG_01060
conserved
hypothetical
prote in
[Coprobacillus
sp. D7]
643112755
CLONEX_00261
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
nexile DSM
1787] 644096990
PROPEN_01698
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Proteus
penneri ATCC
35198]
651350965
HMPREF0987_00485
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
644227085
EUBHAL_01530
electron
transport
complex,
RnfABCDGE
type, D subunit
[Eubacterium
hallii DSM 3353]
646108045
HMPREF0494_0359
conserved
hypothetical
prote in
[Lactobacillus
antri DSM
16041]
643115410
CLONEX_02919
electron
transport
complex,
RnfABCDGE
type, D subunit
[Clostridium
nexile DSM
1787]
647938633
HMPREF0485_01509
hypothetical
prote in
[Klebsiella sp.
1_1_55]
651550285
HMPREF9538_04048
fimbria l prote in
[Klebsiella sp.
MS 92-3]
650540371
CCU_24070
Predicted
integral
membrane
prote in
[Coprococcus
sp. ART55/1]
648582837
HMPREF9547_04045
general
secretion
pathway protein
L [Escherichia
coli MS 175-1]
650565199
ROI_08320
Predicted
hydrolase
(metallo-beta-lactamase
superfamily)
[Roseburia
intestinalis
M 50/1]
647489320
HMPREF0281_00213
glutamate
transport
ATP-bind ing
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
651516134
HMPREF9412_2818
HD domain
prote in
[Paenibacillus
sp. HGF5]
645274522
Bfra3_010100003045
putative
esterase
[Bacteroides
fragilis 3_1_12]
650521373
AL1_09950
hypothetical
prote in
[Alistipes shahii
WAL 8301]
648535729
HMPREF9540_04347
PRD domain
prote in
[Escherichia coli
MS 115-1]
648926749
HMPREF0326_01475
rhomboid family
prote in
[Desulfovibrio
sp. 3_1_syn3]
643148124
PROVALCAL_03811
hypothetical
prote in
[Providencia
alcalifaciens
DSM 30120]
651348165
HMPREF0992_00365
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
644157867
RUMHYD_03541
putative efflux
protein, MATE
family [Blautia
hydrogenotrophica
DSM 10507]
647513117
HMPREF0493_1380
Na /H
antiporter
[Lactobacillus
amylolyticus
DSM 11664]
643135786
COLSTE_01150
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Collinsella
stercoris DSM
13279]
646040106
ChatD1_010100029034
b ind ing-prote in-dependent
transport
systems inner
membrane
component
[Clostridium
hathewayi DSM
13479]
648927399
HMPREF0326_02114
CDP-alcohol
phosphatidyltransferase
family protein
[Desulfovibrio
sp. 3_1_syn3]
646222494
BSCG_01035
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
647876593
HMPREF0103_2485
ABC transporter
permease
[Bacteroides sp.
2_1_33B] 646273445
BSIG_00304
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
650351311
HMPREF9443_01091
hypothetical
prote in
[Phascolarctobacterium
sp. YIT 12067]
650274500
HMPREF9406_1660
hypothetical
prote in
[Clostridium sp.
HGF2]
651351291
HMPREF0987_00810
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA] 651516803
HMPREF9412_0790
pyridine
nucleotide-d isu lfide
oxidoreductase
[Paenibacillus
sp. HGF5]
646213523
BSBG_01832
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
651558500
HMPREF9442_03238
hypothetical
prote in
[Paraprevotella
xylaniphila YIT
11841]
650560145
FPR_30670
conserved
hypothetical
prote in
TIGR00043
[Faecalibacterium
prausnitzii
SL3/3]
644182000
CLOSTASPAR_06618
CAAX amino
terminal
protease family.
[Clostridium
asparagiforme
DSM 15981]
650187840
HMPREF9436_01578
conserved
hypothetical
prote in
TIGR00043
[Faecalibacterium
cf. prausnitzii
KLE1255]
647448781
CUW_0440
DNA-bind ing
prote in
[Turicibacter
sanguinis
PC909]
648925517
HMPREF0326_00253
iron-su lfur
cluster-b ind ing
prote in
[Desulfovibrio
sp. 3_1_syn3] 643913915
Cbac1_010100001995
diguanylate
cyclase/phosphodiesterase
[Clostridiales
sp. 1_7_47FAA]
650521177
AL1_07600
Predicted
hydrolase of the
metallo-beta-lactamase
superfamily
[Alistipes shahii
WAL 8301]
651570860
HMPREF9413_1869
putative
aliphatic
sulfonates
transport
permease
protein SsuC
[Paenibacillus
sp. HGF7]
648564583
HMPREF9530_02026
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 21-1]
646003609
BacD2_010100004621
putative
transmembrane
mobilisation
prote in
[Bacteroides sp.
D2]
651352667
HMPREF0987_02151
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
650186455
HMPREF9436_00192
TraG/TraD
family protein
[Faecalibacterium
cf. prausnitzii
KLE1255]
650545835
EC1_18790
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
cylindroides
T2-87]
650558585
FPR_13180
Type IV
secretory
pathway, VirD4
components
[Faecalibacterium
prausnitzii
SL3/3]
647369369
EDWATA_02100
putative ABC
transporter,
permease
prote in
[Edwardsiella
tarda ATCC
23685]
650187466
HMPREF9436_01203
TraG/TraD
family protein
[Faecalibacterium
cf. prausnitzii
KLE1255]
647941285
HMPREF0485_04125
fimbria l
morphology
[Klebsiella sp.
1_1_55]
651551067
HMPREF9538_04831
ABC
transporter,
substrate-b ind ing
protein, family
5 [Klebsiella sp.
MS 92-3]
651543799
HMPREF9446_01544
polysaccharide
biosynthesis
prote in
[Bacteroides
fluxus YIT
12057] 650055436
HMPREF0177_01823
ribosomal L5P
family protein
[Bifidobacterium
sp.
12_1_47BFAA]
650528031
BIL_04240 LSU
ribosomal
protein L5P
[Bifidobacterium
longum longum
F8]
643913229
BloniC5_010100009395
50S ribosomal
protein L5
[Bifidobacterium
longum longum
CCUG 52486]
651382993
HMPREF9477_00264
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
643911022
BbifN4_010100007817
50S ribosomal
protein L5
[Bifidobacterium
bifidum NCIMB
41171]
646252343
FSAG_01313
conserved
hypothetical
prote in
[Fusobacterium
sp. 2_1_31]
646240441
MBAG_00279
two-component
system
transcriptional
regulator
[Coprobacillus
sp. D7]
643914832
Cbac1_010100006573
auxin efflux
carrier
[Clostridiales
sp. 1_7_47FAA]
647881619
HMPREF0102_03473
DNA
topoisomerase I
[Bacteroides sp.
2_1_22]
643114071
CLONEX_01578
hypothetical
prote in
[Clostridium
nexile DSM
1787]
645351468
E4_010100013999
putative
MFS-family
transport
prote in
[Escherichia sp.
4_1_40B]
647367772
EDWATA_00503
th iamin
metabolism
associated
prote in
[Edwardsiella
tarda ATCC
23685]
647875464
HMPREF0103_1383
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
648908282
HMPREF9008_01652
putative
endonuclease/exonuclease/phosphatase
family protein
[Bacteroides sp.
20_3]
648887083
HMPREF0104_00922
endonuclease/exonuclease/phosphatase
[Bacteroides sp.
3_1_19]
646286485
HMPREF0619_01034
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
651551905
HMPREF9538_05669
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
644393128
HMPREF0539_2484
CPA2 family
monovalent
cation:proton (H
) antiporter-2
[Lactobacillus
rhamnosus
LMS2-1]
651554871
HMPREF9439_02418
permease,
YjgP/YjgQ
family
[Parasutterella
excrementihominis
YIT 11859]
644158927
HOLDEFILI_00670
hypothetical
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
646897627
LRHM_1901 Na
/H antiporter
[Lactobacillus
rhamnosus GG,
ATCC 53103]
648925050
HMPREF0189_02116
permease
YjgP/YjgQ
[Burkholderiales
bacterium
1_1_47]
644328470
HMPREF0530_2293
g lycine--tRNA
ligase
[Lactobacillus
paracasei ATCC
25302]
650082280
HMPREF9475_01584
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
644355109
HMPREF0352_2149
ABC superfamily
ATP binding
cassette
transporter,
membrane
prote in
[Enterococcus
faecium
TX1330]
650559696
FPR_25620
Predicted
membrane
prote in
[Faecalibacterium
prausnitzii
SL3/3]
650077654
HMPREF9474_01708
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
644098745
PROPEN_03458
Uncharacterized
membrane-associated
protein [Proteus
penneri ATCC
35198]
646006165
BacD2_010100017435
hypothetical
prote in
[Bacteroides sp.
D2]
647454257
CUY_0074 PKD
domain prote in
[Bacteroides
ovatus SD CMC
3f]
651357858
HMPREF1017_01886
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
651356872
HMPREF1017_00908
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
643926344
Lparp8_010100001688
Glycyl-tRNA
synthetase beta
subunit
(Glycine--tRNA
ligase beta
subunit) (GlyRS)
[Lactobacillus
paracasei
8700:2]
646007290
BacD2_010100023154
putative phage
integrase
[Bacteroides sp.
D2]
651369250
HMPREF0127_00159
hypothetical
prote in
[Bacteroides sp.
1_1_30]
646221716
BSCG_00263
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
647445068
CUO_1612 ABC
transporter,
permease
prote in
[Enterococcus
faecalis PC4.1]
650521882
AL1_16290
hypothetical
prote in
[Alistipes shahii
WAL 8301]
646274622
BSIG_01466
peptidyl-pro lyl
cis-trans
isomerase
[Bacteroides sp.
1_1_6]
643156423
PRABACTJOHN_02052
putative efflux
protein, MATE
family
[Parabacteroides
johnsonii DSM
18315]
646260622
OFBG_00434
AraJ protein
[Oxalobacter
formigenes
OXCC13]
650063509
HMPREF0864_04057
hypothetical
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
643145705
PROVALCAL_01382
Uncharacterized
membrane-associated
prote in
[Providencia
alcalifaciens
DSM 30120]
644327138
HMPREF0530_0979
ApbE protein
[Lactobacillus
paracasei ATCC
25302]
647879967
HMPREF0102_01841
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
646219318
BSAG_02678
conserved
hypothetical
prote in
[Bacteroides sp.
D1]
646210728
ESAG_04421
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
646224746
BSCG_03264
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
651517449
HMPREF9412_4232
peptidase
propeptide and
YpeB domain
prote in
[Paenibacillus
sp. HGF5]
648894538
HMPREF0106_04079
transcriptional
regulator
[Bacteroides sp.
D22]
648905767
HMPREF9010_03587
transcriptional
regulator
[Bacteroides sp.
3_1_23]
646006668
BacD2_010100020019
putative
regulatory
prote in
[Bacteroides sp.
D2]
650568357
RO1_04000
hypothetical
prote in
[Roseburia
intestinalis
XB6B4]
646289055
HMPREF0619_03567
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
647877251
HMPREF0103_3135
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
648889363
HMPREF0104_03199
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_19]
648924658
HMPREF0189_01578
putative
membrane
prote in
[Burkholderiales
bacterium
1_1_47]
648910841
HMPREF9008_01966
conserved
hypothetical
prote in
[Bacteroides sp.
20_3]
651557268
HMPREF9442_02006
hypothetical
prote in
[Paraprevotella
xylaniphila YIT
11841]
645282361
B2_010100018018
hypothetical
prote in
[Bacteroides sp.
2_1_7]
651554194
HMPREF9439_01741
putative
membrane
prote in
[Parasutterella
excrementihominis
YIT 11859]
651516359
HMPREF9412_4202
transporter,
major facilitator
family protein
[Paenibacillus
sp. HGF5]
648553070
HMPREF9534_00707
conserved
hypothetical
prote in
[Escherichia coli
MS 69-1]
648550252
HMPREF9531_03236
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
646266592
ESCG_01081
peptidase M48
[Escherichia sp.
1_1_43]
648599190
HMPREF9549_04259
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
650273052
HMPREF9406_4121
PRD domain
prote in
[Clostridium sp.
HGF2]
647367697
EDWATA_00428
zinc transporter
ZupT
[Edwardsiella
tarda ATCC
23685] 651384306
HMPREF9477_01558
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
HCV_G1_NS2_794
650020844
HMPREF1004_02309
peptidase M48,
Ste24p
[Ralstonia sp.
5_7_47FAA]
646218492
BSAG_01861
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
D1]
647881767
HMPREF0102_03619
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
2_1_22]
647883902
HMPREF0101_00984
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
651360546
HMPREF1017_04536
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
645275408
Bfra3_010100007497
putative
transmembrane
prote in
[Bacteroides
fragilis 3_1_12]
647454856
CUY_1999
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
648907305
HMPREF9010_04537
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_23]
650044528
HMPREF1023_00208
polysaccharide
biosynthesis
prote in
[Eggerthella sp.
1_3_56FAA]
645278739
Bfra3_010100024112
tetracycline
resistance
prote in
[Bacteroides
fragilis 3_1_12]
650542340
ENC_20750 cell
elongation-specific
peptidoglycan
biosynthesis
regulator RodA
[Enterobacter
cloacae cloacae
NCTC 9394]
644156218
RUMHYD_01891
Arabinose efflux
permease
[Blautia
hydrogenotrophica
DSM 10507]
648542579
HMPREF9543_00631
rod
shape-determin ing
protein RodA
[Escherichia coli
MS 146-1]
643928190
Lparp8_010100010965
ApbE protein
[Lactobacillus
paracasei
8700:2]
643138176
DESPIG_00958
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
647876176
HMPREF0103_2074
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
646270890
BSHG_02296
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
651363368
HMPREF1018_02230
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
646005869
BacD2_010100015975
hypothetical
prote in
[Bacteroides sp.
D2]
647490485
HMPREF0281_01379
cytochrome D
ubiqu ino l
oxidase,
subunit II
[Corynebacterium
ammoniagenes
DSM 20306]
651359699
HMPREF1017_03702
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
648903362
HMPREF9010_00950
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_23]
646002846
BacD2_010100000783
hypothetical
prote in
[Bacteroides sp.
D2]
647784406
HMPREF5045_01842
conserved
hypothetical
prote in
[Lactobacillus
crispatus
125-2-CHN]
646034906
ChatD1_010100002831
PTS system,
mannose-specific
enzyme II, D
component
[Clostridium
hathewayi DSM
13479]
646218180
BSAG_01555
conserved
hypothetical
prote in
[Bacteroides sp.
D1]
643927434
Lparp8_010100007170
UpsA
[Lactobacillus
paracasei
8700:2]
644326193
HMPREF0530_0040
major facilitator
superfamily
permease
[Lactobacillus
paracasei ATCC
25302]
651337790
HMPREF0994_00373
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1] 644156544
RUMHYD_02217
putative efflux
protein, MATE
family [Blautia
hydrogenotrophica
DSM 10507]
646234740
BSFG_02729
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
4_3_47FAA]
647881107
HMPREF0102_02969
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
650559870
FPR_27590 Mg
chelatase-related
prote in
[Faecalibacterium
prausnitzii
SL3/3]
647449446
CUW_2006
hypothetical
prote in
[Turicibacter
sanguinis
PC909]
643135661
COLSTE_01024
PTS system IID
component
[Collinsella
stercoris DSM
13279]
643138931
DESPIG_01714
ABC-type
transport
system involved
in cytochrome c
biogenesis,
permease
component
[Desulfovibrio
piger ATCC
29098] 651569421
HMPREF9413_4458
spore
germination
protein (amino
acid permease)
[Paenibacillus
sp. HGF7]
644161740
HOLDEFILI_03484
hypothetical
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650274220
HMPREF9406_3205
conserved
hypothetical
prote in
[Clostridium sp.
HGF2]
650012078
HMPREF0983_00571
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
647996332
HMPREF0405_00591
PTS system, IIA
component
[Fusobacterium
sp. 3_1_27]
650003490
HMPREF9011_02013
RNA polymerase
ECF-type sigma
factor
[Bacteroides sp.
3_1_40A]
643138613
DESPIG_01396
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
651554749
HMPREF9439_02296
polysulphide
reductase, NrfD
[Parasutterella
excrementihominis
YIT 11859]
648924456
HMPREF0189_01255
molybdopterin
oxidoreductase,
membrane
subunit
[Burkholderiales
bacterium
1_1_47]
650041938
HMPREF1016_01531
hypothetical
prote in
[Bacteroides
eggerthii
1_2_48FAA]
646243192
MBAG_02968
predicted
prote in
[Coprobacillus
sp. D7]
643096126
BACEGG_00893
Predicted thiol
oxidoreductase
[Bacteroides
eggerthii DSM
20697]
643125394
ANHYDRO_01270
Predicted
acyltransferases
[Anaerococcus
hydrogenalis
DSM 7454]
646245037
CSAG_01398
co iled-co il
structure
[Citrobacter sp.
30_2] 644096682
PROPEN_01389
hypothetical
protein [Proteus
penneri ATCC
35198]
650018825
HMPREF1004_00273
ribose transport
system
permease
protein RbsC
[Ralstonia sp.
5_7_47FAA]
648568025
HMPREF9530_05469
hypothetical
prote in
[Escherichia coli
MS 21-1]
651570443
HMPREF9413_3376
stage III
sporulation
protein AE
[Paenibacillus
sp. HGF7]
646239875
CSBG_03190
ferrous ion
transporter
[Clostridium sp.
7_2_43FAA]
647513250
HMPREF0493_1485
undecaprenyl-phosphate
N-acetylglucosaminyl
1-phosphate
transferase
[Lactobacillus
amylolyticus
DSM 11664]
651344887
HMPREF0993_00518
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA] 651514029
HMPREF9412_5634
hypothetical
prote in
[Paenibacillus
sp. HGF5]
647441205
CW3_2556 RNA
polymerase
sigma-70 factor
[Bacteroides
xylanisolvens
SD CC 1b]
643158410
PRABACTJOHN_04040
ABC-type Fe3
-siderophore
transport
system,
permease
component
[Parabacteroides
johnsonii DSM
18315]
647513229
HMPREF0493_1465
glycerophosphodiester
phosphodiesterase
[Lactobacillus
amylolyticus
DSM 11664]
650352655
HMPREF9444_00233
DNA repair
protein RadA
[Succinatimonas
hippei YIT
12066]
646246505
CSAG_02843
zinc transporter
ZupT
[Citrobacter sp.
30_2]
646240298
MBAG_00136
response
regulator gtcR
[Coprobacillus
sp. D7]
651334321
HMPREF0991_00492
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
646034843
ChatD1_010100002516
two component
transcriptional
regulator
[Clostridium
hathewayi DSM
13479]
650078170
HMPREF9474_02222
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
650529019
BIL_15830
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Bifidobacterium
longum longum
F8]
643911655
BloniC5_010100001597
two component
transcriptional
regulator,
winged helix
family protein
[Bifidobacterium
longum longum
CCUG 52486]
650053971
HMPREF0177_00401
response
regulator
receiver
domain-conta in ing
prote in
[Bifidobacterium
sp.
12_1_47BFAA]
643152183
BIFCAT_01601
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Bifidobacterium
catenulatum
DSM 16992]
650018713
HMPREF1004_00160
DNA-bind ing
response
regulator BaeS
[Ralstonia sp.
5_7_47FAA]
646211739
BSBG_00068
two-component
system
response
regulator
[Bacteroides sp.
9_1_42FAA]
651335675
HMPREF0991_01838
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
651516506
HMPREF9412_1462
response
regulator
receiver domain
prote in
[Paenibacillus
sp. HGF5]
650072112
HMPREF9488_00103
regulatory
protein VanR
[Coprobacillus
sp. 29_1]
651328980
HMPREF0990_01202
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
650583550
RTO_14940
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
torques L2-14]
651352652
HMPREF0987_02136
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
643916040
Cbac1_010100012595
two component
transcriptional
regulator
[Clostridiales
sp. 1_7_47FAA]
651334302
HMPREF0991_00473
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650048577
HMPREF1026_01264
regulatory
protein VanR
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
644158210
RUMHYD_03885
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
650273899
HMPREF9406_2869
putative alkaline
phosphatase
synthesis
transcriptional
regulatory
protein SphR
[Clostridium sp.
HGF2] 650538248
CC1_31290
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
catus GD/7]
650083770
HMPREF9475_03059
two component
transcriptional
regulator
[Clostridium
symbiosum
WAL-14673]
644175565
CLOSTASPAR_00179
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
asparagiforme
DSM 15981]
647888822
HMPREF0105_1221
two-component
system
response
regulator
[Bacteroides sp.
3_1_33FAA]
643910965
BbifN4_010100007552
Putative
response
regulator
[Bifidobacterium
bifidum NCIMB
41171] 650550824
ERE_21470
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
recta le M104/1]
651327783
HMPREF0990_00024
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
651368750
HMPREF1025_02614
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
647454002
CUY_1159
TonB-dependent
receptor
[Bacteroides
ovatus SD CMC
3f]
648906153
HMPREF9010_02532
putative
TonB-linked
outer
membrane
prote in
[Bacteroides sp.
3_1_23]
651679153
HMPREF9418_1688
hypothetical
prote in
[Neisseria
macacae ATCC
33926]
647490056
HMPREF0281_00949
DNA-bind ing
response
regulator RegX3
[Corynebacterium
ammoniagenes
DSM 20306]
650014312
HMPREF0983_02941
DNA-bind ing
response
regulator
[Erysipelotrichaceae
bacterium sp.
3_1_53]
644345527
HMPREF0175_0217
response
regulator
[Bifidobacterium
longum longum
ATCC 55813]
651359077
HMPREF1017_03091
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
647370267
EDWATA_02998
transporter, bile
acid/Na
symporter
family
[Edwardsiella
tarda ATCC
23685]
651352346
HMPREF0987_01835
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
651549998
HMPREF9538_03761
a lpha-2-macroglobulin
family protein
[Klebsiella sp.
MS 92-3] 648596161
HMPREF9549_01227
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 185-1]
648535710
HMPREF9540_04328
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 115-1]
648549529
HMPREF9531_02512
a lpha-2-macroglobulin
family protein
[Escherichia coli
MS 45-1]
648578596
HMPREF9541_05078
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 116-1]
646245963
CSAG_02311
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
648590646
HMPREF9551_01425
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 196-1]
646209669
ESAG_03367
lipoprote in
YfhM
[Escherichia sp.
3_2_53FAA]
648573133
HMPREF9535_04718
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 78-1]
647937160
HMPREF0485_00057
a lpha-2-macroglobulin
domain-conta in ing
prote in
[Klebsiella sp.
1_1_55]
648589185
HMPREF9553_05410
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 200-1]
648541614
HMPREF9548_05101
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 182-1]
648567542
HMPREF9530_04986
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 21-1]
648546704
HMPREF9543_04758
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 146-1]
648583332
HMPREF9547_04541
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 175-1]
648527945
HMPREF9536_02390
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 84-1]
648522384
HMPREF9552_02552
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 198-1]
650543681
ENC_37380
Large
extracellular
alpha-helical
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
647437874
CUU_1065
sensor histidine
kinase/response
regulator
[Bacteroides
vulgatus PC510]
647451638
CUY_1056
ATPase/histidine
kinase/DNA
gyrase B/HSP90
domain prote in
[Bacteroides
ovatus SD CMC
3f]
651338089
HMPREF0994_00670
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1] 646007225
BacD2_010100022829
putative
two-component
system sensor
histidine kinase
[Bacteroides sp.
D2]
651356933
HMPREF1017_00969
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
644327032
HMPREF0530_0873
MFS family
major facilitator
transporter,
multidrug:cation
symporter
[Lactobacillus
paracasei ATCC
25302]
646226323
BSCG_04820
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
643928297
Lparp8_010100011512
Permease of the
major facilitator
superfamily
prote in
[Lactobacillus
paracasei
8700:2]
648903824
HMPREF9010_01407
putative
two-component
system sensor
histidine kinase
[Bacteroides sp.
3_1_23]
650353805
HMPREF9444_01402
transcriptional
regulatory
protein QseB
[Succinatimonas
hippei YIT
12066]
645344213
ShiD9_010100000355
hypothetical
protein [Shigella
sp. D9] 648556405
HMPREF9534_04042
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 69-1]
648560404
HMPREF9550_02451
a lpha-2-macroglobulin
family region
[Escherichia coli
MS 187-1] 644327776
HMPREF0530_1607
NhaP family Na
/H and K /H
antiporter
[Lactobacillus
paracasei ATCC
25302]
644161907
HOLDEFILI_03651
Membrane
protein involved
in the export o f
O-antigen and
teichoic acid
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
643928669
Lparp8_010100013371
YvgP
[Lactobacillus
paracasei
8700:2]
646283834
FVAG_02657
conserved
hypothetical
prote in
[Fusobacterium
varium ATCC
27725]
650087411
HMPREF9464_00619
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
646002803
BacD2_010100000568
N-acetylmuramoyl-L-a lan ine
amidase
[Bacteroides sp.
D2]
650574998
RUM_15990
putative efflux
protein, MATE
family
[Ruminococcus
sp. 18P13]
646242026
MBAG_01837
predicted
prote in
[Coprobacillus
sp. D7]
650541405
ENC_08520
Uncharacterized
prote in
conserved in
bacteria
[Enterobacter
cloacae cloacae
NCTC 9394]
650543850
ENC_39510
Signal
transduction
histidine kinase
[Enterobacter
cloacae cloacae
NCTC 9394]
643915962
Cbac1_010100012205
two component
transcriptional
regulator
[Clostridiales
sp. 1_7_47FAA]
647856605
HMPREF0847_01147
conserved
hypothetical
prote in
[Streptococcus
sp. 2_1_36FAA]
643140230
DESPIG_03013
Di- and
tricarboxylate
transporters
[Desulfovibrio
piger ATCC
29098] 648924183
HMPREF0189_02183
sodium/g lutamate
symporter
[Burkholderiales
bacterium
1_1_47]
643137621
DESPIG_00401
ABC-type
d ipeptide
transport
system,
periplasmic
component
[Desulfovibrio
piger ATCC
29098]
644227147
EUBHAL_01592
Na -dependent
transporters of
the SNF family
[Eubacterium
hallii DSM 3353]
644155082
RUMHYD_00756
hypothetical
protein [Blautia
hydrogenotrophica
DSM 10507]
650543663
ENC_37180
transcriptional
antiterminator,
BglG family
[Enterobacter
cloacae cloacae
NCTC 9394]
650012796
HMPREF0983_01339
ABC
transporter,
permease
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
644169926
BACCELL_05090
Non-ribosomal
peptide
synthetase
modules and
related proteins
[Bacteroides
cellulosilyticus
DSM 14838]
650576721
CK1_12190 Na
-dr iven
multidrug efflux
pump
[Ruminococcus
sp. SR1/5]
650020206
HMPREF1004_01668
transcriptional
regulatory
protein QseB
[Ralstonia sp.
5_7_47FAA]
651678342
HMPREF9418_0897
response
regulator
[Neisseria
macacae ATCC
33926]
643137894
DESPIG_00676
ABC-type
uncharacterized
transport
system,
periplasmic
component
[Desulfovibrio
piger ATCC
29098]
643099872
BACPEC_00871
cysteine
desulfurase NifS
[Bacteroides
pectinophilus
ATCC 43243]
645276838
Bfra3_010100014649
putative
transmembrane
prote in
[Bacteroides
fragilis 3_1_12]
650566001
ROI_17670 IgA
Peptidase M64.
[Roseburia
intestinalis
M 50/1]
650575422
RUM_20860
hypothetical
prote in
[Ruminococcus
sp. 18P13]
648903849
HMPREF9010_01433
polysaccharide
biosynthesis
prote in domain
prote in
[Bacteroides sp.
3_1_23]
651678855
HMPREF9418_1399
hypothetical
prote in
[Neisseria
macacae ATCC
33926]
651338131
HMPREF0994_00712
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650013732
HMPREF0983_02316
transcriptional
regulator, MarR
family
[Erysipelotrichaceae
bacterium sp.
3_1_53]
647887857
HMPREF0105_0268
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_33FAA]
643909662
BbifN4_010100001047
hypothetical
prote in
[Bifidobacterium
bifidum NCIMB
41171]
643913009
BloniC5_010100008329
hypothetical
prote in
[Bifidobacterium
longum longum
CCUG 52486]
643910289
BbifN4_010100004190
hypothetical
prote in
[Bifidobacterium
bifidum NCIMB
41171] 646898052
LRHM_2325
transporter
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
650534858
CLS_30740 Na
-dependent
transporters of
the SNF family
[Clostridium cf.
saccharolyticum
K10]
651553786
HMPREF9439_01333
sodium/g lutamate
symporter
[Parasutterella
excrementihominis
YIT 11859]
650350886
HMPREF9443_00666
Sodium:neurotransmitter
symporter
family protein
[Phascolarctobacterium
sp. YIT 12067]
650350909
HMPREF9443_00689
Sodium:neurotransmitter
symporter
family protein
[Phascolarctobacterium
sp. YIT 12067]
646270278
BSHG_01689
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
644315843
HMPREF0545_0288
ABC superfamily
ATP binding
cassette
transporter,
membrane
prote in
[Lactobacillus
salivarius
HO66, ATCC
11741]
650005166
HMPREF9011_03669
sensor protein
[Bacteroides sp.
3_1_40A]
651517808
HMPREF9412_3949
N-acetylmuramoyl-L-a lan ine
amidase
[Paenibacillus
sp. HGF5]
647857235
HMPREF0847_01769
conserved
hypothetical
prote in
[Streptococcus
sp. 2_1_36FAA]
647448658
CUW_2547 ABC
transporter,
permease
prote in
[Turicibacter
sanguinis
PC909]
647370121
EDWATA_02852
inner membrane
protein YfcA
[Edwardsiella
tarda ATCC
23685]
646002946
BacD2_010100001283
putative
mobilization
protein TraG
family
[Bacteroides sp.
D2]
646277193
BSIG_04012
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
650273398
HMPREF9406_3683
ABC
transporter,
permease
prote in
[Clostridium sp.
HGF2]
651558188
HMPREF9442_02925
hypothetical
prote in
[Paraprevotella
xylaniphila YIT
11841]
650319166
HMPREF9420_0389
GPH family
glycoside-pentoside-hexuronide:cation
symporter
[Prevotella
salivae DSM
15606]
651340874
HMPREF0994_03446
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1] 650073106
HMPREF9488_01082
hypothetical
prote in
[Coprobacillus
sp. 29_1]
650272338
HMPREF9406_1825
putative
membrane
prote in
[Clostridium sp.
HGF2]
648927663
HMPREF0326_02374
methyltransferase
GidB
[Desulfovibrio
sp. 3_1_syn3] 650352605
HMPREF9444_00183
ABC
transporter,
permease
prote in
[Succinatimonas
hippei YIT
12066]
647938792
HMPREF0485_01668
abrB; protein
AbrB [Klebsiella
sp. 1_1_55]
646037866
ChatD1_010100017714
ethanolamine
utilization
protein EutH
[Clostridium
hathewayi DSM
13479]
648927385
HMPREF0326_02100
sodium Bile acid
symporter
family protein
[Desulfovibrio
sp. 3_1_syn3]
651333681
HMPREF0988_03059
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
650073271
HMPREF9488_01247
major facilitator
superfamily
transporter
[Coprobacillus
sp. 29_1]
646304761
HMPREF0026_02212
th iamine-monophosphate
kinase
[Acinetobacter
junii SH205]
644164937
BACCELL_00099
hypothetical
prote in
[Bacteroides
cellulosilyticus
DSM 14838]
648883933
HMPREF9007_02764
glycosyl
hydrolase,
family 88
[Bacteroides sp.
1_1_14]
648524244
HMPREF9552_04413
flagella basal
body P-ring
formation
protein FlgA
[Escherichia coli
MS 198-1]
650521300
AL1_09070
Site-specific
recombinase
XerD [Alistipes
shahii WAL
8301]
651345375
HMPREF0993_00993
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
646266056
HWAG_01420
conserved
hypothetical
prote in
[Helicobacter
winghamensis
ATCC BAA-430]
650085017
HMPREF9459_00062
monovalent
cation:proton
antipor ter -2
family
transporter
[Streptococcus
anginosus
1_2_62CV]
650530980
CIY_18160
electron
transport
complex,
RnfABCDGE
type, C
subunit/e lectron
transport
complex,
RnfABCDGE
type, D subunit
[Butyrivibrio
fibrisolvens
16/4]
650557766
FPR_04100
conserved
hypothetical
integral
membrane
prote in
TIGR02206
[Faecalibacterium
prausnitzii
SL3/3]
644208299
CLOSTMETH_02255
Na -driven
multidrug efflux
pump
[Clostridium
methylpentosum
R2, DSM 5476]
644097941
PROPEN_02651
1-acyl-sn-g lycero l-3-phosphate
acyltransferase
[Proteus penneri
ATCC 35198]
643919984
HcanM9_010100001108
putative integral
membrane
prote in
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
646034930
ChatD1_010100002951
hypothetical
prote in
[Clostridium
hathewayi DSM
13479] 651330971
HMPREF0988_00398
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651330960
HMPREF0988_00387
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
644157490
RUMHYD_03164
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
650274308
HMPREF9406_1465
putative
membrane
prote in
[Clostridium sp.
HGF2]
646274062
BSIG_00909
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
647370430
EDWATA_03161
putative inner
membrane or
exported
[Edwardsiella
tarda ATCC
23685]
651357034
HMPREF1017_01070
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
644177488
CLOSTASPAR_02103
Predicted
membrane
prote in
[Clostridium
asparagiforme
DSM 15981]
643928701
Lparp8_010100013541
hypothetical
prote in
[Lactobacillus
paracasei
8700:2]
646108401
HMPREF0494_0710
amino acid ABC
superfamily ATP
binding cassette
transporter,
membrane
prote in
[Lactobacillus
antri DSM
16041]
650352148
HMPREF9443_01929
hypothetical
prote in
[Phascolarctobacterium
sp. YIT 12067]
650060347
HMPREF0864_00937
basic amino
acid/po lyamine
antiporter
family
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
644168281
BACCELL_03444
TonB dependent
receptor.
[Bacteroides
cellulosilyticus
DSM 14838]
647370380
EDWATA_03110
glutamate/aspartate
ABC
transporter,
periplasmic
g lu tamate/aspartate-b ind ing
prote in
[Edwardsiella
tarda ATCC
23685] 651312936
HMPREF0240_01890
DNA-bind ing
response
regulator RegX3
[Clostridium sp.
D5]
646211741
BSBG_00070
AcrB/AcrD/AcrF
family protein
[Bacteroides sp.
9_1_42FAA]
648883341
HMPREF9007_02132
uracil permease
[Bacteroides sp.
1_1_14]
651384533
HMPREF9477_01784
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
643114547
CLONEX_02055
carbohydrate
ABC transporter
membrane
protein 1, CUT1
family (TC
3.A.1.1.-)/carbohydrate
ABC transporter
membrane
protein 2, CUT1
family (TC
3.A.1.1.-)
[Clostridium
nexile DSM
1787]
643156266
PRABACTJOHN_01895
ABC-type
antimicrobial
peptide
transport
system,
permease
component
[Parabacteroides
johnsonii DSM
18315]
647888824
HMPREF0105_1223
acriflavin
resistance
prote in
[Bacteroides sp.
3_1_33FAA]
644157725
RUMHYD_03399
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
647491191
HMPREF0281_02085
putative
microtubule-associated
prote in 4
[Corynebacterium
ammoniagenes
DSM 20306]
651369194
HMPREF0127_00103
hypothetical
prote in
[Bacteroides sp.
1_1_30]
644155105
RUMHYD_00778
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
651371030
HMPREF0127_01919
hypothetical
prote in
[Bacteroides sp.
1_1_30]
647457759
CW1_1769
glycosyl
hydrolase family
16 [Bacteroides
ovatus SD CC
2a]
648537017
HMPREF9548_00501
hypothetical
prote in
[Escherichia coli
MS 182-1]
648592355
HMPREF9551_03134
SWIM zinc
finger prote in
[Escherichia coli
MS 196-1]
647441096
CW3_0437
glycosyl
hydrolase family
16 [Bacteroides
xylanisolvens
SD CC 1b]
650046216
HMPREF1023_01875
luxR family
Bacterial
regulatory
prote in
[Eggerthella sp.
1_3_56FAA]
648892132
HMPREF0106_01655
two-component
system sensor
histidine kinase
[Bacteroides sp.
D22]
644435123
HMPREF0535_0306
APC family
amino
acid-polyamine-organocation
transporter
[Lactobacillus
reuteri MM2-3]
646219602
BSAG_02956
conserved
hypothetical
prote in
[Bacteroides sp.
D1]
647878259
HMPREF0102_00158
beta-glucanase
[Bacteroides sp.
2_1_22]
648891192
HMPREF0106_00709
cation efflux
system protein
CzcA
[Bacteroides sp.
D22]
648569652
HMPREF9535_01235
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
647441650
CW3_4761
ATPase/histidine
kinase/DNA
gyrase B/HSP90
domain prote in
[Bacteroides
xylanisolvens
SD CC 1b]
647436778
CUU_0850 TraG
family protein
[Bacteroides
vulgatus PC510]
647879635
HMPREF0102_01515
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
650538649
CCU_01460
Histidine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Coprococcus
sp. ART55/1]
650028232
HMPREF1011_01667
hypothetical
prote in
[Anaerostipes
sp. 3_2_56FAA]
651334915
HMPREF0991_01083
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
651312711
HMPREF0240_01665
response
regulator
[Clostridium sp.
D5]
646239102
CSBG_02440
DNA repair
protein RecO
[Clostridium sp.
7_2_43FAA]
648568745
HMPREF9535_00328
SWIM zinc
finger prote in
[Escherichia coli
MS 78-1]
645349143
E4_010100002372
zinc finger
SWIM
domain-conta in ing
prote in
[Escherichia sp.
4_1_40B]
648598446
HMPREF9549_03515
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
648525975
HMPREF9536_00418
SWIM zinc
finger prote in
[Escherichia coli
MS 84-1]
648534362
HMPREF9540_02979
conserved
hypothetical
prote in
[Escherichia coli
MS 115-1]
648542746
HMPREF9543_00799
SWIM zinc
finger prote in
[Escherichia coli
MS 146-1]
648568334
HMPREF9530_05779
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
648548423
HMPREF9531_01405
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
645346412
ShiD9_010100011362
hypothetical
protein [Shigella
sp. D9]
644344746
HMPREF0534_1621
APC family
amino
acid-polyamine-organocation
transporter
[Lactobacillus
reuteri
CF48-3A]
644226941
EUBHAL_01386
hypothetical
prote in
[Eubacterium
hallii DSM 3353]
646238388
CSBG_01728
uracil-xanth ine
permease
[Clostridium sp.
7_2_43FAA]
651544460
HMPREF9446_02206
TonB-dependent
receptor plug
domain prote in
[Bacteroides
fluxus YIT
12057]
643914384
Cbac1_010100004332
hypothetical
prote in
[Clostridiales
sp. 1_7_47FAA]
651538931
HMPREF9445_00006
hypothetical
prote in
[Bacteroides
clarus YIT
12056]
650574631
RUM_11900
hypothetical
prote in
[Ruminococcus
sp. 18P13]
650541359
ENC_07840
n itrite extrusion
protein (nitrite
facilitator)
[Enterobacter
cloacae cloacae
NCTC 9394]
650086700
HMPREF9459_01697
hypothetical
prote in
[Streptococcus
anginosus
1_2_62CV]
650321086
HMPREF9420_2279
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
643925469
HpulM9_010100007901
putative integral
membrane
prote in
[Helicobacter
pullorum MIT
98-5489]
650319672
HMPREF9420_0886
endoglucanase
A [Prevotella
salivae DSM
15606]
648927110
HMPREF0326_01827
uracil permease
[Desulfovibrio
sp. 3_1_syn3]
651331235
HMPREF0988_00659
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
650046221
HMPREF1023_01880
luxR family
Bacterial
regulatory
prote in
[Eggerthella sp.
1_3_56FAA]
647371092
EDWATA_03825
putative
cytoplasmic
prote in
[Edwardsiella
tarda ATCC
23685] 644272099
ROSEINA2194_03598
Major Facilitator
Superfamily.
[Roseburia
inulinivorans
DSM 16841]
647940954
HMPREF0485_03799
prote in
transporter
HofQ [Klebsiella
sp. 1_1_55]
651339791
HMPREF0994_02365
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650560384
GPA_02860
Domain of
unknown
function
(DUF1836).
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
646282847
FVAG_01366
conserved
hypothetical
prote in
[Fusobacterium
varium ATCC
27725]
647987131
HMPREF0873_01246
major facilitator
family
transporter
[Veillonella sp.
3_1_44]
647989100
HMPREF0874_01337
major facilitator
family
transporter
[Veillonella sp.
6_1_27]
643095923
BACEGG_00690
hypothetical
prote in
[Bacteroides
eggerthii DSM
20697]
650041550
HMPREF1016_01145
hypothetical
prote in
[Bacteroides
eggerthii
1_2_48FAA]
651571285
HMPREF9413_3486
hypothetical
prote in
[Paenibacillus
sp. HGF7] 651548263
HMPREF9538_02025
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
646238812
CSBG_02151
MATE efflux
family protein
[Clostridium sp.
7_2_43FAA]
648923907
HMPREF0189_00826
inner membrane
protein YhaI
[Burkholderiales
bacterium
1_1_47]
651554582
HMPREF9439_02129
hypothetical
prote in
[Parasutterella
excrementihominis
YIT 11859]
648563701
HMPREF9530_01144
flagella basal
body P-ring
formation
protein FlgA
[Escherichia coli
MS 21-1]
645965778
FulcA4_010100005665
putative sugar
metabolism
repressor
[Fusobacterium
ulcerans ATCC
49185]
650022960
HMPREF1004_04413
transmembrane
sensor histidine
kinase
transcription
regulator
prote in
[Ralstonia sp.
5_7_47FAA]
644208944
CLOSTMETH_02901
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
methylpentosum
R2, DSM 5476]
643139324
DESPIG_02107
methenyltetrahydrofolate
cyclohydrolase
(EC
3.5.4.9)/5 ,10-methylenetetrahydrofo la te
dehydrogenase
(NADP ) (EC
1.5.1.5)
[Desulfovibrio
piger ATCC
29098]
647784252
HMPREF5045_01691
conserved
hypothetical
prote in
[Lactobacillus
crispatus
125-2-CHN]
650544491
ENC_47750
Arabinose efflux
permease
[Enterobacter
cloacae cloacae
NCTC 9394]
647368731
EDWATA_01462
conserved
hypothetical
prote in
[Edwardsiella
tarda ATCC
23685]
646041475
ChatD1_010100035847
amino-acid ABC
transporter
permease
prote in
[Clostridium
hathewayi DSM
13479]
646262401
HRAG_00091
sodium/g lutamate
symporter
[Helicobacter
bilis ATCC
43879]
644177962
CLOSTASPAR_02577
Transcriptional
regulator
[Clostridium
asparagiforme
DSM 15981]
646109773
HMPREF0494_2036
response
regulator
[Lactobacillus
antri DSM
16041]
644344776
HMPREF0534_1649
response
regulator
[Lactobacillus
reuteri
CF48-3A]
650063304
HMPREF0864_03860
hypothetical
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
651369162
HMPREF0127_00071
hypothetical
prote in
[Bacteroides sp.
1_1_30]
647892601
HMPREF9024_00285
osmoprotectant
transport
system
substrate-b ind ing
prote in
[Pediococcus
acidilactici 7_4]
650580105
CK5_12560
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
obeum A2-162]
644435160
HMPREF0535_0341
response
regulator
[Lactobacillus
reuteri MM2-3] 650198397
HMPREF0623_1105
g lycine/beta ine/carn itine/choline
ABC superfamily
ATP binding
cassette
transporter,
b ind ing prote in
[Pediococcus
acidilactici DSM
20284]
647897256
HMPREF0969_01185
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
651568999
HMPREF9413_6023
transcriptional
regulatory
protein WalR
[Paenibacillus
sp. HGF7]
646244390
CSAG_00757
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
647529889
HMPREF0219_1902
ABC superfamily
ATP binding
cassette
transporter,
permease
prote in
[Clostridium
difficile NAP07]
648895073
HMPREF0106_04612
hypothetical
prote in
[Bacteroides sp.
D22]
650081787
HMPREF9475_01093
DNA repair
protein RadC
[Clostridium
symbiosum
WAL-14673]
646038385
ChatD1_010100020340
DNA repair
protein RadC
[Clostridium
hathewayi DSM
13479]
651368926
HMPREF1025_02790
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
651345128
HMPREF0993_00747
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
647509401
HMPREF0220_1492
ABC superfamily
ATP binding
cassette
transporter,
permease
prote in
[Clostridium
difficile NAP08]
648892107
HMPREF0106_01630
polysaccharide
biosynthesis
prote in domain
prote in
[Bacteroides sp.
D22]
650079975
HMPREF9474_04000
DNA repair
protein RadC
[Clostridium
symbiosum
WAL-14163]
651327857
HMPREF0990_00095
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
650597584
CK3_21470
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridiales
sp. SS3/4]
650579334
CK5_03260
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
obeum A2-162]
651366247
HMPREF1025_00147
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
645958586
BcroD2_010100003712
two component
transcriptional
regulator
[Butyrivibrio
crossotus DSM
2876]
651334829
HMPREF0991_00997
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650049714
HMPREF1026_02380
DNA-bind ing
response
regulator SrrA
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
650574051
RUM_05360
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. 18P13]
644156492
RUMHYD_02165
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
648574891
HMPREF9541_01372
response
regulator
receiver domain
prote in
[Escherichia coli
MS 116-1]
648521171
HMPREF9552_01338
response
regulator
receiver domain
prote in
[Escherichia coli
MS 198-1]
644168836
BACCELL_04000
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Bacteroides
cellulosilyticus
DSM 14838]
645965953
FulcA4_010100006540
transcriptional
regulatory
prote in
[Fusobacterium
ulcerans ATCC
49185] 648526019
HMPREF9536_00462
response
regulator
receiver domain
prote in
[Escherichia coli
MS 84-1]
648536628
HMPREF9548_00112
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 182-1]
650533248
CLS_10620
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium cf.
saccharolyticum
K10]
644103778
COPCOM_03500
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
comes ATCC
27758]
646006297
BacD2_010100018123
two component
transcriptional
regulator,
winged helix
family protein
[Bacteroides sp.
D2]
647368444
EDWATA_01175
DNA-bind ing
response
regulator BaeS
[Edwardsiella
tarda ATCC
23685]
645344636
ShiD9_010100002452
DNA-bind ing
transcriptional
regulator BaeR
[Shigella sp. D9]
651314744
HMPREF0240_03709
DNA-bind ing
response
regulator
[Clostridium sp.
D5]
648536526
HMPREF9548_00010
response
regulator
receiver domain
prote in
[Escherichia coli
MS 182-1]
651367621
HMPREF1025_01498
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
648532322
HMPREF9540_00938
response
regulator
receiver domain
prote in
[Escherichia coli
MS 115-1]
648566915
HMPREF9530_04359
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 21-1]
645350078
E4_010100007069
outer
membrane
lipoprotein LolB
[Escherichia sp.
4_1_40B]
645345439
ShiD9_010100006474
outer
membrane
lipoprotein LolB
[Shigella sp. D9] 648594459
HMPREF9551_05239
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 196-1]
648546575
HMPREF9543_04629
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 146-1]
651366282
HMPREF1025_00182
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
648535454
HMPREF9540_04072
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 115-1]
644208050
CLOSTMETH_02005
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
methylpentosum
R2, DSM 5476]
648530395
HMPREF9536_04842
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 84-1]
646208177
ESAG_01899
outer
membrane
lipoprotein LolB
[Escherichia sp.
3_2_53FAA]
644427974
HMPREF0555_0092
response
regulator
[Leuconostoc
mesenteroides
cremoris ATCC
19254]
646283006
FVAG_01525
transcription
regulator
[Fusobacterium
varium ATCC
27725]
644289553
HMPREF0497_2646
response
regulator
[Lactobacillus
buchneri ATCC
11577]
646109630
HMPREF0494_1896
DNA-bind ing
response
regulator
[Lactobacillus
antri DSM
16041]
645962027
F3_010100008131
two component
transcriptional
regulator
[Fusobacterium
sp. 3_1_5R]
644343636
HMPREF0534_0531
response
regulator
[Lactobacillus
reuteri
CF48-3A]
647446465
CUO_1493
response
regulator
receiver domain
prote in
[Enterococcus
faecalis PC4.1] 647856183
HMPREF0847_00726
transcriptional
regulatory
protein CiaR
[Streptococcus
sp. 2_1_36FAA]
644353468
HMPREF0352_0544
response
regulator
[Enterococcus
faecium
TX1330]
650588927
ENT_30770
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Enterococcus
sp. 7L76] 644434909
HMPREF0535_0093
response
regulator
[Lactobacillus
reuteri MM2-3]
644294135
HMPREF0348_0957
response
regulator
[Enterococcus
faecalis
TX0104]
650197423
HMPREF0623_0160
response
regulator
[Pediococcus
acidilactici DSM
20284]
646248560
FMAG_00145
two-component
response
regulator
[Fusobacterium
mortiferum
ATCC 9817]
646897378
LRHM_1662
two-component
response
regulator
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644392418
HMPREF0539_1784
response
regulator
[Lactobacillus
rhamnosus
LMS2-1] 644429265
HMPREF0555_1351
response
regulator
[Leuconostoc
mesenteroides
cremoris ATCC
19254]
648689315
HMPREF9521_01162
response
regulator
receiver domain
prote in
[Enterococcus
faecalis
TX2134]
644286481
HMPREF0496_2678
response
regulator
[Lactobacillus
brevis
gravesensis
ATCC 27305]
650085340
HMPREF9459_00386
transcriptional
regulatory
protein ciaR
[Streptococcus
anginosus
1_2_62CV]
644315637
HMPREF0545_0084
response
regulator
[Lactobacillus
salivarius
HO66, ATCC
11741]
644328285
HMPREF0530_2110
response
regulator
[Lactobacillus
paracasei ATCC
25302]
645969647
FgonA2_010100008298
two component
transcriptional
regulator
[Fusobacterium
gonidiaformans
ATCC 25563]
647892925
HMPREF9024_00608
two-component
system, OmpR
family, KDP
operon
response
regulator KdpE
[Pediococcus
acidilactici 7_4]
643926956
Lparp8_010100004776
Response
regulator
[Lactobacillus
paracasei
8700:2]
646250976
FMAG_02517
two-component
system
response
regulator
[Fusobacterium
mortiferum
ATCC 9817]
651349499
HMPREF0992_01668
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
650568182
RO1_01950
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Roseburia
intestinalis
XB6B4]
650075668
HMPREF9488_03598
winged helix
family Two
component
transcriptional
regulator
[Coprobacillus
sp. 29_1]
651327892
HMPREF0990_00130
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
648561171
HMPREF9550_03220
response
regulator
receiver domain
prote in
[Escherichia coli
MS 187-1]
650013542
HMPREF0983_02119
DNA-bind ing
response
regulator
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650582295
RTO_00490
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
torques L2-14]
648542156
HMPREF9543_00208
response
regulator
receiver domain
prote in
[Escherichia coli
MS 146-1]
648548833
HMPREF9531_01815
response
regulator
receiver domain
prote in
[Escherichia coli
MS 45-1]
650047615
HMPREF1026_00312
DNA-bind ing
response
regulator ResD
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
644162228
HOLDEFILI_03973
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650047581
HMPREF1026_00278
regulatory
protein VanR
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651344589
HMPREF0993_00224
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
650575801
CK1_00830
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. SR1/5]
647937496
HMPREF0485_00385
two-component
system, OmpR
family, response
regulator BaeR
[Klebsiella sp.
1_1_55]
650543945
ENC_40880
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Enterobacter
cloacae cloacae
NCTC 9394]
645349178
E4_010100002547
DNA-bind ing
transcriptional
regulator BaeR
[Escherichia sp.
4_1_40B]
648588565
HMPREF9553_04790
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 200-1]
651515558
HMPREF9412_6107
response
regulator
receiver domain
prote in
[Paenibacillus
sp. HGF5]
650581958
CK5_33360
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
obeum A2-162]
646255759
FSDG_00204
two-component
response
regulator
[Fusobacterium
sp. 7_1]
644155523
RUMHYD_01196
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
647825319
HMPREF0406_00317
phosphate
regulon
transcriptional
regulatory
protein PhoB
[Fusobacterium
sp. 3_1_33]
648558561
HMPREF9550_00608
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 187-1]
650198560
HMPREF0623_1268
response
regulator
[Pediococcus
acidilactici DSM
20284]
651567601
HMPREF9413_4557
response
regulator
receiver domain
prote in
[Paenibacillus
sp. HGF7]
644391130
HMPREF0539_0505
response
regulator
[Lactobacillus
rhamnosus
LMS2-1]
650577460
CK1_20980
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. SR1/5]
644326217
HMPREF0530_0064
response
regulator
[Lactobacillus
paracasei ATCC
25302]
647892446
HMPREF9024_00130
two-component
system, OmpR
family, response
regulator VicR
[Pediococcus
acidilactici 7_4] 644316783
HMPREF0545_1212
response
regulator
[Lactobacillus
salivarius
HO66, ATCC
11741]
651354183
HMPREF0401_00927
DNA-bind ing
response
regulator ArlR
[Fusobacterium
sp. 11_3_2]
648595883
HMPREF9549_00949
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 185-1]
644355451
HMPREF0352_2490
VicR family
response
regulator
[Enterococcus
faecium
TX1330]
645354663
PrD11_010100006731
two-component
response
regulator
[Fusobacterium
sp. D11]
647446259
CUO_0862
response
regulator
receiver domain
prote in
[Enterococcus
faecalis PC4.1]
651382034
HMPREF0404_01292
hypothetical
prote in
[Fusobacterium
sp. 21_1A]
646898447
LRHM_2706
two-component
response
regulator
[Lactobacillus
rhamnosus GG,
ATCC 53103]
645959424
BcroD2_010100007878
two component
transcriptional
regulator
[Butyrivibrio
crossotus DSM
2876]
643927411
Lparp8_010100007055
Putative
response
regulator
[Lactobacillus
paracasei
8700:2]
648578503
HMPREF9541_04985
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 116-1]
650541340
ENC_07580
outer
membrane
lipoprotein LolB
[Enterobacter
cloacae cloacae
NCTC 9394]
648580272
HMPREF9547_01478
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 175-1]
648520745
HMPREF9552_00911
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 198-1]
648570397
HMPREF9535_01981
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 78-1]
648552414
HMPREF9534_00051
outer
membrane
lipoprotein LolB
[Escherichia coli
MS 69-1]
646245234
CSAG_01593
outer-membrane
lipoprotein lolB
[Citrobacter sp.
30_2]
648881468
HMPREF9007_00157
TraG family
prote in
[Bacteroides sp.
1_1_14]
644346240
HMPREF0175_0912
ribosomal
protein L5
[Bifidobacterium
longum longum
ATCC 55813]
646244540
CSAG_00903
TonB-dependent
ferric aerobactin
receptor
[Citrobacter sp.
30_2]
650350272
HMPREF9443_00052
putative stage V
sporulation
protein B
[Phascolarctobacterium
sp. YIT 12067]
651331585
HMPREF0988_01004
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
644167961
BACCELL_03124
Acetyl esterase
(deacetylase)
[Bacteroides
cellulosilyticus
DSM 14838]
643183074
EUBIFOR_00310
hypothetical
prote in
[Eubacterium
biforme DSM
3989] 650013400
HMPREF0983_01968
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
643918050
Cbac1_010100022597
ATPase, P-type
(transporting),
HAD
superfamily,
subfamily IC
[Clostridiales
sp. 1_7_47FAA]
648926935
HMPREF0326_01658
th io l-d isu lfide
oxidoreductase
ResA
[Desulfovibrio
sp. 3_1_syn3]
643120559
BACDOR_01468
Protein of
unknown
function
DUF262.
[Bacteroides
dorei DSM
17855]
650028024
HMPREF1011_01461
electron
transport
complex
[Anaerostipes
sp. 3_2_56FAA]
650577629
CK1_22980
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. SR1/5]
643125657
ANHYDRO_01532
Transcriptional
regulators
[Anaerococcus
hydrogenalis
DSM 7454]
645347140
ShiD9_010100015005
flagella basal
body P-ring
formation
protein FlgA
[Shigella sp. D9]
648545315
HMPREF9543_03368
flagella basal
body P-ring
formation
protein FlgA
[Escherichia coli
MS 146-1]
644269017
ROSEINA2194_00513
electron
transport
complex,
RnfABCDGE
type, D subunit
[Roseburia
inulinivorans
DSM 16841]
650532492
CLS_01480
hypothetical
prote in
[Clostridium cf.
saccharolyticum
K10]
643158602
PRABACTJOHN_04232
ABC-type
transport
system,
involved in
lipoprote in
release,
permease
component
[Parabacteroides
johnsonii DSM
18315]
647941898
HMPREF0485_04735
yciW [Klebsiella
sp. 1_1_55]
647371191
EDWATA_03924
putative outer
membrane
lipoprote in
[Edwardsiella
tarda ATCC
23685]
650556336
FP2_20450 Na
-dr iven
multidrug efflux
pump
[Faecalibacterium
prausnitzii
L2-6]
650575275
RUM_19190
Major Facilitator
Superfamily.
[Ruminococcus
sp. 18P13]
646276919
BSIG_03740
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
650042047
HMPREF1016_01642
hypothetical
prote in
[Bacteroides
eggerthii
1_2_48FAA]
648884758
HMPREF9007_03609
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_14]
651542009
HMPREF9445_03085
conserved
domain prote in
[Bacteroides
clarus YIT
12056]
643117308
CLOHIR_00518
Abortive
in fection
bacteriophage
resistance
prote in
[Clostridium
hiranonis
TO-931 DSM
13275]
644206274
CLOSTMETH_00227
Na -dependent
transporters of
the SNF family
[Clostridium
methylpentosum
R2, DSM 5476]
651344078
HMPREF0994_06610
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
651339789
HMPREF0994_02363
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
643102079
BACPEC_03081
Na /H
antiporter NhaC
[Bacteroides
pectinophilus
ATCC 43243]
648926836
HMPREF0326_01561
CgeB family
prote in
[Desulfovibrio
sp. 3_1_syn3]
646240785
MBAG_00622
MATE efflux
family protein
[Coprobacillus
sp. D7]
650573908
RUM_03770
Predicted
meta l-dependent
enzyme
[Ruminococcus
sp. 18P13]
647997509
HMPREF0400_02241
conserved
hypothetical
prote in
[Fusobacterium
sp. 1_1_41FAA]
646230664
BSEG_03137
predicted
prote in
[Bacteroides
dore i
5_1_36/D4]
646207468
ESAG_01195
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648597081
HMPREF9549_02148
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
648562108
HMPREF9550_04157
conserved
hypothetical
prote in
[Escherichia coli
MS 187-1]
648577600
HMPREF9541_04082
conserved
hypothetical
prote in
[Escherichia coli
MS 116-1]
648538424
HMPREF9548_01908
hypothetical
prote in
[Escherichia coli
MS 182-1]
648554934
HMPREF9534_02571
conserved
hypothetical
prote in
[Escherichia coli
MS 69-1]
648543331
HMPREF9543_01384
conserved
hypothetical
prote in
[Escherichia coli
MS 146-1]
646246516
CSAG_02854
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
648525255
HMPREF9552_05424
conserved
hypothetical
prote in
[Escherichia coli
MS 198-1]
648547495
HMPREF9531_00477
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
648584824
HMPREF9553_01047
hypothetical
prote in
[Escherichia coli
MS 200-1]
648532625
HMPREF9540_01242
conserved
hypothetical
prote in
[Escherichia coli
MS 115-1]
647940344
HMPREF0485_03192
SH3
domain-conta in ing
prote in
[Klebsiella sp.
1_1_55]
648582946
HMPREF9547_04154
hypothetical
prote in
[Escherichia coli
MS 175-1]
646267494
ESCG_00555
conserved
hypothetical
prote in
[Escherichia sp.
1_1_43]
648569067
HMPREF9535_00650
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
645351348
E4_010100013397
putative signal
transduction
prote in
[Escherichia sp.
4_1_40B]
648548303
HMPREF9531_01285
n itrite
transporter
[Escherichia coli
MS 45-1]
648589432
HMPREF9551_00210
n itrite
transporter
[Escherichia coli
MS 196-1]
648529351
HMPREF9536_03798
hypothetical
prote in
[Escherichia coli
MS 84-1]
648590379
HMPREF9551_01157
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
645345208
ShiD9_010100005322
n itra te/n itrite
transporter
[Shigella sp. D9]
648534018
HMPREF9540_02635
n itrite
transporter
[Escherichia coli
MS 115-1]
648542691
HMPREF9543_00744
n itrite
transporter
[Escherichia coli
MS 146-1]
648559818
HMPREF9550_01865
n itrite
transporter
[Escherichia coli
MS 187-1]
648568629
HMPREF9535_00212
n itrite
transporter
[Escherichia coli
MS 78-1]
648584503
HMPREF9553_00726
n itrite
transporter
[Escherichia coli
MS 200-1]
648595742
HMPREF9549_00808
n itrite
transporter
[Escherichia coli
MS 185-1]
645349811
E4_010100005734
n itra te/n itrite
transporter
[Escherichia sp.
4_1_40B]
648530814
HMPREF9536_05261
n itrite
transporter
[Escherichia coli
MS 84-1]
648566494
HMPREF9530_03937
n itrite
transporter
[Escherichia coli
MS 21-1] 648540453
HMPREF9548_03939
n itrite
transporter
[Escherichia coli
MS 182-1]
648580757
HMPREF9547_01964
n itrite
transporter
[Escherichia coli
MS 175-1]
651548707
HMPREF9538_02469
SH3 domain
prote in
[Klebsiella sp.
MS 92-3]
648564949
HMPREF9530_02392
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
645345932
ShiD9_010100008932
putative signal
transduction
protein [Shigella
sp. D9]
647439152
CUU_0391
Ser/Thr
phosphatase
family protein
[Bacteroides
vulgatus PC510]
646272940
BSHG_04310
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
645280207
B2_010100007225
hypothetical
prote in
[Bacteroides sp.
2_1_7]
647453003
CUY_3090
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
647457856
CW1_1136
conserved
hypothetical
prote in
[Bacteroides
ovatus SD CC
2a]
646245001
CSAG_01362
n itra te
extrusion
prote in
[Citrobacter sp.
30_2]
648520759
HMPREF9552_00925
n itrite
transporter
[Escherichia coli
MS 198-1]
648575191
HMPREF9541_01672
n itrite
transporter
[Escherichia coli
MS 116-1]
648556869
HMPREF9534_04507
n itrite
transporter
[Escherichia coli
MS 69-1]
646208459
ESAG_02177
n itrite extrusion
prote in 2
[Escherichia sp.
3_2_53FAA]
648577453
HMPREF9541_03935
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 116-1]
645346273
ShiD9_010100010671
b ifunctional
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Shigella sp. D9] 650353365
HMPREF9444_00949
putative
response
regulator ArlR
[Succinatimonas
hippei YIT
12066]
648543763
HMPREF9543_01816
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 146-1]
648537902
HMPREF9548_01386
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 182-1]
648530149
HMPREF9536_04596
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 84-1]
648592206
HMPREF9551_02985
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 196-1] 648561497
HMPREF9550_03546
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 187-1]
645351648
E4_010100014899
b ifunctional
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia sp.
4_1_40B]
648582667
HMPREF9547_03875
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 175-1]
648569570
HMPREF9535_01153
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 78-1]
646267158
ESCG_00221
2-acyl-g lycerophospho-ethanolamine
acyltransferase
[Escherichia sp.
1_1_43]
648535354
HMPREF9540_03972
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 115-1]
648592313
HMPREF9551_03092
response
regulator
receiver domain
prote in
[Escherichia coli
MS 196-1]
651314684
HMPREF0240_03647
DNA-bind ing
response
regulator
[Clostridium sp.
D5]
648585695
HMPREF9553_01918
response
regulator
receiver domain
prote in
[Escherichia coli
MS 200-1]
651550858
HMPREF9538_04621
response
regulator
receiver domain
prote in
[Klebsiella sp.
MS 92-3]
651349568
HMPREF0992_01734
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
648579802
HMPREF9547_01008
response
regulator
receiver domain
prote in
[Escherichia coli
MS 175-1]
648554547
HMPREF9534_02184
response
regulator
receiver domain
prote in
[Escherichia coli
MS 69-1]
644270601
ROSEINA2194_02099
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Roseburia
inulinivorans
DSM 16841]
647490427
HMPREF0281_01320
DNA-bind ing
response
regulator MtrA
[Corynebacterium
ammoniagenes
DSM 20306]
651348001
HMPREF0992_00201
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
651384516
HMPREF9477_01767
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
643146297
PROVALCAL_01976
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Providencia
alcalifaciens
DSM 30120]
648564170
HMPREF9530_01613
response
regulator
receiver domain
prote in
[Escherichia coli
MS 21-1]
646209165
ESAG_02873
transcriptional
response
regulatory
prote in
[Escherichia sp.
3_2_53FAA]
651314733
HMPREF0240_03698
DNA-bind ing
response
regulator
[Clostridium sp.
D5] 646245584
CSAG_01938
transcriptional
response
regulatory
prote in
[Citrobacter sp.
30_2]
648572731
HMPREF9535_04315
response
regulator
receiver domain
prote in
[Escherichia coli
MS 78-1] 651331560
HMPREF0988_00979
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651569949
HMPREF9413_5486
transcriptional
regulatory
protein ResD
[Paenibacillus
sp. HGF7]
650565712
ROI_14320
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Roseburia
intestinalis
M 50/1]
643114390
CLONEX_01898
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
nexile DSM
1787]
651330086
HMPREF0990_02291
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
651342293
HMPREF0994_04848
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
648597747
HMPREF9549_02816
response
regulator
receiver domain
prote in
[Escherichia coli
MS 185-1]
650061421
HMPREF0864_01997
response
regulator
receiver
domain-conta in ing
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
650049957
HMPREF1026_02608
Sodium:neurotransmitter
symporter
family protein
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651517794
HMPREF9412_5414
ABC
transporter,
permease
prote in
[Paenibacillus
sp. HGF5]
643913669
Cbac1_010100000750
sodium/chloride-dependent
transporter
[Clostridiales
sp. 1_7_47FAA]
651330547
HMPREF0990_02737
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
644104095
COPCOM_03817
Na -dependent
transporters of
the SNF family
[Coprococcus
comes ATCC
27758]
647938212
HMPREF0485_01088
AAT family
amino acid
transporter
[Klebsiella sp.
1_1_55]
651312387
HMPREF0240_01338
sodium:neurotransmitter
symporter
family protein
[Clostridium sp.
D5]
650011347
HMPREF1007_03542
MATE efflux
family protein
[Bacteroides sp.
4_1_36]
646245025
CSAG_01386
L-asparagine
permease
[Citrobacter sp.
30_2]
651332283
HMPREF0988_01691
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA] 650541479
ENC_09510
Gamma-aminobutyrate
permease and
related
permeases
[Enterobacter
cloacae cloacae
NCTC 9394]
643113667
CLONEX_01173
Na -dependent
transporters of
the SNF family
[Clostridium
nexile DSM
1787]
651547377
HMPREF9538_01138
putative
pro line-specific
permease ProY
[Klebsiella sp.
MS 92-3]
651347990
HMPREF0992_00190
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
651384033
HMPREF9477_01286
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
646224671
BSCG_03189
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
650027058
HMPREF1011_00502
response
regulator
receiver
domain-conta in ing
prote in
[Anaerostipes
sp. 3_2_56FAA]
644159264
HOLDEFILI_01008
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650572933
RBR_14290
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
bromii L2-63]
646235435
BSFG_03417
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
644147332
BACCOPRO_03663
hypothetical
prote in
[Bacteroides
coprophilus
DSM 18228]
648894922
HMPREF0106_04465
surface layer
protein B
[Bacteroides sp.
D22]
651365908
HMPREF1018_04726
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647884079
HMPREF0101_01154
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
651369528
HMPREF0127_00428
hypothetical
prote in
[Bacteroides sp.
1_1_30]
651365947
HMPREF1018_04765
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647442742
CW3_2189
conserved
hypothetical
prote in
[Bacteroides
xylanisolvens
SD CC 1b]
645275543
Bfra3_010100008171
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
645281706
B2_010100014727
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
2_1_7] 651360105
HMPREF1017_04100
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
647456770
CW1_3795
GHMP kinase,
N-terminal
domain prote in
[Bacteroides
ovatus SD CC
2a]
647899093
HMPREF0969_02994
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
D20]
646231869
BSEG_04331
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides
dore i
5_1_36/D4]
651370204
HMPREF0127_01098
hypothetical
prote in
[Bacteroides sp.
1_1_30]
648909507
HMPREF9008_00024
putative GHMP
kinase putative
ATP-bind ing
prote in
[Bacteroides sp.
20_3]
646287887
HMPREF0619_02416
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Parabacteroides
sp. D13]
648890713
HMPREF0106_00238
GHMP kinase
ATP-bind ing
prote in
[Bacteroides sp.
D22]
651363845
HMPREF1018_02692
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
643121543
BACDOR_02452
Predicted kinase
related to
galactokinase
and mevalonate
kinase
[Bacteroides
dorei DSM
17855]
648881630
HMPREF9007_00322
GHMP kinase
ATP-bind ing
prote in
[Bacteroides sp.
1_1_14]
646224780
BSCG_03298
fucose kinase
[Bacteroides sp.
2_2_4]
650001445
HMPREF9011_00002
hypothetical
prote in
[Bacteroides sp.
3_1_40A]
648888708
HMPREF0104_02545
GHMP kinase
ATP-bind ing
prote in
[Bacteroides sp.
3_1_19]
647874334
HMPREF0103_0269
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
2_1_33B]
651558620
HMPREF9442_03358
GHMP kinase
prote in
[Paraprevotella
xylaniphila YIT
11841]
646234122
BSFG_02119
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
4_3_47FAA]
646219262
BSAG_02623
fucose kinase
[Bacteroides sp.
D1]
647880019
HMPREF0102_01892
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
647892174
HMPREF0105_4529
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
3_1_33FAA]
646006637
BacD2_010100019869
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
D2]
646276480
BSIG_03305
fucose kinase
[Bacteroides sp.
1_1_6]
650010334
HMPREF1007_02538
L-fucokinase
[Bacteroides sp.
4_1_36]
645351411
E4_010100013714
phosphate
transporter
[Escherichia sp.
4_1_40B]
651546269
HMPREF9538_00030
ferric
enterobactin
transport
system
permease
protein FepD
[Klebsiella sp.
MS 92-3]
646247385
CSAG_03712
phosphate
transporter
[Citrobacter sp.
30_2]
648550203
HMPREF9531_03187
phosphate
transporter
family protein
[Escherichia coli
MS 45-1]
646207550
ESAG_01277
inorganic
phosphate
transporter
[Escherichia sp.
3_2_53FAA]
648538353
HMPREF9548_01837
phosphate
transporter
family protein
[Escherichia coli
MS 182-1] 648554055
HMPREF9534_01692
phosphate
transporter
family protein
[Escherichia coli
MS 69-1]
648589963
HMPREF9551_00741
phosphate
transporter
family protein
[Escherichia coli
MS 196-1]
647884729
HMPREF0101_01789
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
2_1_16]
646216100
BSBG_04378
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
9_1_42FAA]
647438712
CUU_3740
GHMP kinase,
N-terminal
domain prote in
[Bacteroides
vulgatus PC510]
643157158
PRABACTJOHN_02787
Predicted kinase
related to
galactokinase
and mevalonate
kinase
[Parabacteroides
johnsonii DSM
18315] 647439816
CW3_3143
GHMP kinase,
N-terminal
domain prote in
[Bacteroides
xylanisolvens
SD CC 1b]
648905795
HMPREF9010_03616
putative GHMP
kinase putative
ATP-bind ing
prote in
[Bacteroides sp.
3_1_23]
651545943
HMPREF9446_03689
GHMP kinase
prote in
[Bacteroides
fluxus YIT
12057]
645276000
Bfra3_010100010446
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides
fragilis 3_1_12]
647455532
CUY_1341
GHMP kinase,
N-terminal
domain prote in
[Bacteroides
ovatus SD CMC
3f]
644144364
BACCOPRO_00693
Predicted kinase
related to
galactokinase
and mevalonate
kinase
[Bacteroides
coprophilus
DSM 18228]
646272728
BSHG_04101
b ifunctional
fucokinase/L-fucose-1-P-guanylyltransferase
[Bacteroides sp.
3_2_5]
643923624
HcinC1_010100010991
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
651335281
HMPREF0991_01447
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
645346024
ShiD9_010100009414
GspL-like
protein [Shigella
sp. D9]
648529469
HMPREF9536_03916
general
secretion
pathway protein
L [Escherichia
coli MS 84-1]
648542305
HMPREF9543_00357
general
secretion
pathway protein
L [Escherichia
coli MS 146-1] 648547620
HMPREF9531_00602
general
secretion
pathway protein
L [Escherichia
coli MS 45-1]
648577709
HMPREF9541_04191
general
secretion
pathway protein
L [Escherichia
coli MS 116-1]
648597206
HMPREF9549_02273
general
secretion
pathway protein
L [Escherichia
coli MS 185-1] 648589926
HMPREF9551_00704
general
secretion
pathway protein
L [Escherichia
coli MS 196-1]
648552499
HMPREF9534_00136
putative general
secretion
pathway protein
L [Escherichia
coli MS 69-1]
648524170
HMPREF9552_04339
general
secretion
pathway protein
L [Escherichia
coli MS 198-1]
645351444
E4_010100013879
GspL-like
prote in
[Escherichia sp.
4_1_40B]
646207583
ESAG_01310
general
secretion
pathway protein
L [Escherichia
sp. 3_2_53FAA]
648562002
HMPREF9550_04051
general
secretion
pathway protein
L [Escherichia
coli MS 187-1]
648588004
HMPREF9553_04229
general
secretion
pathway protein
L [Escherichia
coli MS 200-1]
648538318
HMPREF9548_01802
general
secretion
pathway protein
L [Escherichia
coli MS 182-1]
646267403
ESCG_00464
general
secretion
pathway protein
GspL
[Escherichia sp.
1_1_43]
647988972
HMPREF0874_01219
hydroxylamine
reductase
[Veillonella sp.
6_1_27]
647986996
HMPREF0873_01121
hydroxylamine
reductase
[Veillonella sp.
3_1_44]
648925521
HMPREF0326_00257
hydroxylamine
reductase
[Desulfovibrio
sp. 3_1_syn3]
643140242
DESPIG_03025
hydroxylamine
reductase
[Desulfovibrio
piger ATCC
29098]
643148133
PROVALCAL_03820
hydroxylamine
reductase
[Providencia
alcalifaciens
DSM 30120]
647939014
HMPREF0485_01888
ybaE [Klebsiella
sp. 1_1_55]
650002896
HMPREF9011_01426
hypothetical
prote in
[Bacteroides sp.
3_1_40A]
646229982
BSEG_02464
predicted
prote in
[Bacteroides
dore i
5_1_36/D4]
646233096
BSFG_01103
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
650569834
RO1_20980
Predicted
hydrolase
(metallo-beta-lactamase
superfamily)
[Roseburia
intestinalis
XB6B4]
647436376
CUU_2644
putative
membrane
prote in
[Bacteroides
vulgatus PC510]
648593429
HMPREF9551_04209
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
650080762
HMPREF9475_00071
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
647940874
HMPREF0485_03719
inner membrane
protein yhhT
[Klebsiella sp.
1_1_55]
650543429
ENC_34360
Uncharacterized
prote in
conserved in
bacteria
[Enterobacter
cloacae cloacae
NCTC 9394]
651552043
HMPREF9538_05807
YeeE/YedE
family protein
[Klebsiella sp.
MS 92-3]
646247358
CSAG_03685
PerM family
permease
[Citrobacter sp.
30_2] 651547639
HMPREF9538_01400
autoinducer 2
exporter TqsA
[Klebsiella sp.
MS 92-3]
647899543
HMPREF0969_03438
predicted
prote in
[Bacteroides sp.
D20]
648570177
HMPREF9535_01761
general
secretion
pathway protein
L [Escherichia
coli MS 78-1]
643150736
BIFCAT_00151
Predicted
membrane
prote in
[Bifidobacterium
catenulatum
DSM 16992]
650009119
HMPREF1007_01337
CobD/Cbib
prote in
[Bacteroides sp.
4_1_36] 644101395
COPCOM_01114
hydroxylamine
reductase
[Coprococcus
comes ATCC
27758]
651547936
HMPREF9538_01698
low-affin ity
inorganic
phosphate
transporter 1
[Klebsiella sp.
MS 92-3]
646267937
ESCG_01610
p itA prote in
[Escherichia sp.
1_1_43]
648542279
HMPREF9543_00331
phosphate
transporter
family protein
[Escherichia coli
MS 146-1]
648577672
HMPREF9541_04154
phosphate
transporter
family protein
[Escherichia coli
MS 116-1]
648552474
HMPREF9534_00111
phosphate
transporter
family protein
[Escherichia coli
MS 69-1]
648524207
HMPREF9552_04376
phosphate
transporter
family protein
[Escherichia coli
MS 198-1]
648547583
HMPREF9531_00565
phosphate
transporter
family protein
[Escherichia coli
MS 45-1] 648587016
HMPREF9553_03240
phosphate
transporter
family protein
[Escherichia coli
MS 200-1]
648582874
HMPREF9547_04082
phosphate
transporter
family protein
[Escherichia coli
MS 175-1]
648529431
HMPREF9536_03878
phosphate
transporter
family protein
[Escherichia coli
MS 84-1]
645352783
E4_010100020596
phosphate
transporter,
low-affin ity
[Escherichia sp.
4_1_40B]
648532150
HMPREF9540_00766
phosphate
transporter
family protein
[Escherichia coli
MS 115-1] 648599141
HMPREF9549_04210
phosphate
transporter
family protein
[Escherichia coli
MS 185-1]
648569137
HMPREF9535_00720
phosphate
transporter
family protein
[Escherichia coli
MS 78-1]
648577773
HMPREF9541_04255
phosphate
transporter
family protein
[Escherichia coli
MS 116-1]
648588041
HMPREF9553_04266
phosphate
transporter
family protein
[Escherichia coli
MS 200-1]
646210786
ESAG_04479
phosphate
transporter
[Escherichia sp.
3_2_53FAA]
645347765
ShiD9_010100018120
phosphate
transporter,
low-affin ity
[Shigella sp. D9]
648544002
HMPREF9543_02055
phosphate
transporter
family protein
[Escherichia coli
MS 146-1]
647940848
HMPREF0485_03693
PiT family
inorganic
phosphate
transporter
[Klebsiella sp.
1_1_55]
648565398
HMPREF9530_02841
phosphate
transporter
family protein
[Escherichia coli
MS 21-1]
648541316
HMPREF9548_04802
phosphate
transporter
family protein
[Escherichia coli
MS 182-1] 648530851
HMPREF9536_05298
phosphate
transporter
family protein
[Escherichia coli
MS 84-1]
648559972
HMPREF9550_02019
phosphate
transporter
family protein
[Escherichia coli
MS 187-1] 648531830
HMPREF9540_00446
phosphate
transporter
family protein
[Escherichia coli
MS 115-1]
648562038
HMPREF9550_04087
phosphate
transporter
family protein
[Escherichia coli
MS 187-1]
648597169
HMPREF9549_02236
phosphate
transporter
family protein
[Escherichia coli
MS 185-1]
648573957
HMPREF9541_00437
conserved
domain prote in
[Escherichia coli
MS 116-1]
647939228
HMPREF0485_02101
iron-enterobactin
transporter
membrane
prote in
[Klebsiella sp.
1_1_55]
648572651
HMPREF9535_04235
phosphate
transporter
family protein
[Escherichia coli
MS 78-1]
645352828
E4_010100020821
hypothetical
prote in
[Escherichia sp.
4_1_40B]
648522755
HMPREF9552_02923
phosphate
transporter
family protein
[Escherichia coli
MS 198-1]
648581383
HMPREF9547_02590
conserved
domain prote in
[Escherichia coli
MS 175-1]
648581919
HMPREF9547_03126
phosphate
transporter
family protein
[Escherichia coli
MS 175-1]
648591388
HMPREF9551_02167
phosphate
transporter
family protein
[Escherichia coli
MS 196-1]
648532449
HMPREF9540_01066
conserved
hypothetical
prote in
[Escherichia coli
MS 115-1]
648908371
HMPREF9008_01739
TraG family
prote in
[Bacteroides sp.
20_3]
646216024
BSBG_04302
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
647456489
CW1_4444 TraG
family protein
[Bacteroides
ovatus SD CC
2a]
647874675
HMPREF0103_0606
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B] 647441509
CW3_3210 TraG
family protein
[Bacteroides
xylanisolvens
SD CC 1b]
648911216
HMPREF9008_02788
TraG family
prote in
[Bacteroides sp.
20_3]
643095695
BACEGG_00462
hypothetical
prote in
[Bacteroides
eggerthii DSM
20697]
650043387
HMPREF1016_02962
hypothetical
prote in
[Bacteroides
eggerthii
1_2_48FAA]
647452814
CUY_2315 TraG
family protein
[Bacteroides
ovatus SD CMC
3f]
647451456
CUY_2517 TraG
family protein
[Bacteroides
ovatus SD CMC
3f]
651546204
HMPREF9446_03950
glycosyltransferase,
group 2 family
prote in
[Bacteroides
fluxus YIT
12057]
648911104
HMPREF9008_03941
polysaccharide
export outer
membrane
prote in
[Bacteroides sp.
20_3]
647896700
HMPREF0969_00643
two-component
system sensor
histidine
kinase/response
regulator
[Bacteroides sp.
D20]
646287521
HMPREF0619_02052
polysaccharide
export outer
membrane
prote in
[Parabacteroides
sp. D13]
645281841
B2_010100015396
polysaccharide
export outer
membrane
prote in
[Bacteroides sp.
2_1_7]
644169125
BACCELL_04289
Glycosyltransferases,
probably
involved in cell
wall biogenesis
[Bacteroides
cellulosilyticus
DSM 14838]
650008916
HMPREF1007_01141
glycosyl
transferase
family 2
[Bacteroides sp.
4_1_36]
648889861
HMPREF0104_03691
polysaccharide
export outer
membrane
prote in
[Bacteroides sp.
3_1_19]
646215145
BSBG_03427
NADH
dehydrogenase
subunit I N
[Bacteroides sp.
9_1_42FAA]
650005860
HMPREF9011_04355
NADH
dehydrogenase
subunit I N
[Bacteroides sp.
3_1_40A]
647888556
HMPREF0105_0957
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_33FAA]
651362598
HMPREF1018_01466
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
646230887
BSEG_03359
NADH
dehydrogenase
subunit I N
[Bacteroides
dore i
5_1_36/D4]
648904339
HMPREF9010_01931
TraG family
prote in
[Bacteroides sp.
3_1_23]
643122432
BACDOR_03341
NADH
dehydrogenase
subunit N (EC
1.6.5.3)
[Bacteroides
dorei DSM
17855]
650319837
HMPREF9420_1050
peptide-transporting
ATPase
[Prevotella
salivae DSM
15606]
647891240
HMPREF0105_3604
NADH
dehydrogenase
subunit I N
[Bacteroides sp.
3_1_33FAA]
648554506
HMPREF9534_02143
SWIM zinc
finger prote in
[Escherichia coli
MS 69-1]
645344598
ShiD9_010100002262
hypothetical
protein [Shigella
sp. D9]
651545422
HMPREF9446_03168
ABC
transporter,
ATP-bind ing
prote in
[Bacteroides
fluxus YIT
12057]
646234681
BSFG_02670
NADH
dehydrogenase
subunit I N
[Bacteroides sp.
4_3_47FAA]
647437678
CUU_0673
proton-translocating
NADH-quinone
oxidoreductase,
chain N
[Bacteroides
vulgatus PC510]
648559570
HMPREF9550_01617
SWIM zinc
finger prote in
[Escherichia coli
MS 187-1] 648576949
HMPREF9541_03431
heme exporter
protein CcmB
[Escherichia coli
MS 116-1]
646209303
ESAG_03010
heme exporter
protein B
[Escherichia sp.
3_2_53FAA] 648585563
HMPREF9553_01786
heme exporter
protein CcmB
[Escherichia coli
MS 200-1]
648533998
HMPREF9540_02615
heme exporter
protein CcmB
[Escherichia coli
MS 115-1]
645349066
E4_010100001992
heme exporter
subunit,
membrane
component o f
ABC superfamily
prote in
[Escherichia sp.
4_1_40B] 648564295
HMPREF9530_01738
heme exporter
protein CcmB
[Escherichia coli
MS 21-1]
648560673
HMPREF9550_02720
heme exporter
protein CcmB
[Escherichia coli
MS 187-1]
648521774
HMPREF9552_01941
heme exporter
protein CcmB
[Escherichia coli
MS 198-1]
648571821
HMPREF9535_03405
heme exporter
protein CcmB
[Escherichia coli
MS 78-1]
648597879
HMPREF9549_02948
heme exporter
protein CcmB
[Escherichia coli
MS 185-1]
648525893
HMPREF9536_00336
heme exporter
protein CcmB
[Escherichia coli
MS 84-1]
648545549
HMPREF9543_03602
heme exporter
protein CcmB
[Escherichia coli
MS 146-1]
645344518
ShiD9_010100001865
heme exporter
subunit,
membrane
component o f
ABC superfamily
protein [Shigella
sp. D9]
648540842
HMPREF9548_04328
heme exporter
protein CcmB
[Escherichia coli
MS 182-1]
648539167
HMPREF9548_02652
SWIM zinc
finger prote in
[Escherichia coli
MS 182-1] 648532278
HMPREF9540_00894
SWIM zinc
finger prote in
[Escherichia coli
MS 115-1]
646245707
CSAG_02060
heme exporter
protein B
[Citrobacter sp.
30_2]
648591509
HMPREF9551_02288
heme exporter
protein CcmB
[Escherichia coli
MS 196-1]
648581437
HMPREF9547_02644
heme exporter
protein CcmB
[Escherichia coli
MS 175-1]
648555287
HMPREF9534_02924
heme exporter
protein CcmB
[Escherichia coli
MS 69-1]
648549758
HMPREF9531_02742
heme exporter
protein CcmB
[Escherichia coli
MS 45-1]
648570316
HMPREF9535_01900
tetratricopeptide
repeat protein
[Escherichia coli
MS 78-1]
648579257
HMPREF9547_00463
tetratricopeptide
repeat protein
[Escherichia coli
MS 175-1]
648528547
HMPREF9536_02992
tetratricopeptide
repeat protein
[Escherichia coli
MS 84-1]
647369730
EDWATA_02461
TPR domain
prote in
[Edwardsiella
tarda ATCC
23685]
648590888
HMPREF9551_01667
tetratricopeptide
repeat protein
[Escherichia coli
MS 196-1]
644099427
PROPEN_04140
Predicted
N-acetylglucosaminyl
transferase
[Proteus penneri
ATCC 35198]
648521407
HMPREF9552_01574
tetratricopeptide
repeat protein
[Escherichia coli
MS 198-1]
648545707
HMPREF9543_03760
tetratricopeptide
repeat protein
[Escherichia coli
MS 146-1]
651548272
HMPREF9538_02034
tetratricopeptide
repeat protein
[Klebsiella sp.
MS 92-3]
648575407
HMPREF9541_01888
tetratricopeptide
repeat protein
[Escherichia coli
MS 116-1]
650060968
HMPREF0864_01550
TPR
repeat-conta in ing
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
648563004
HMPREF9530_00446
tetratricopeptide
repeat protein
[Escherichia coli
MS 21-1]
648595197
HMPREF9549_00263
tetratricopeptide
repeat protein
[Escherichia coli
MS 185-1]
648534559
HMPREF9540_03176
tetratricopeptide
repeat protein
[Escherichia coli
MS 115-1]
648552677
HMPREF9534_00314
tetratricopeptide
repeat protein
[Escherichia coli
MS 69-1]
648547212
HMPREF9531_00194
tetratricopeptide
repeat protein
[Escherichia coli
MS 45-1]
648558120
HMPREF9550_00167
tetratricopeptide
repeat protein
[Escherichia coli
MS 187-1]
648583829
HMPREF9553_00051
tetratricopeptide
repeat protein
[Escherichia coli
MS 200-1]
645349968
E4_010100006529
tetratricopeptide
repeat protein
[Escherichia sp.
4_1_40B]
647941891
HMPREF0485_04728
yciM [Klebsiella
sp. 1_1_55]
643147148
PROVALCAL_02831
Predicted
N-acetylglucosaminyl
transferase
[Providencia
alcalifaciens
DSM 30120]
646245154
CSAG_01515
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
645345368
ShiD9_010100006122
tetratricopeptide
repeat protein
[Shigella sp. D9] 648541183
HMPREF9548_04669
tetratricopeptide
repeat protein
[Escherichia coli
MS 182-1]
646208317
ESAG_02035
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648551588
HMPREF9531_04573
AMP-bind ing
enzyme
[Escherichia coli
MS 45-1]
647511091
HMPREF0220_3160
transcriptional
regulator FeuP
[Clostridium
difficile NAP08]
650003859
HMPREF9011_02382
polysaccharide
biosynthesis
prote in
[Bacteroides sp.
3_1_40A]
648893001
HMPREF0106_02542
TraG family
prote in
[Bacteroides sp.
D22] 647528089
HMPREF0219_0113
transcriptional
regulator FeuP
[Clostridium
difficile NAP07]
646209019
ESAG_02727
peptide
synthetase
[Escherichia sp.
3_2_53FAA]
648600192
HMPREF9549_05262
AMP-bind ing
enzyme
[Escherichia coli
MS 185-1]
644392680
HMPREF0539_2037
MFS family
major facilitator
transporter,
multidrug:cation
symporter
[Lactobacillus
rhamnosus
LMS2-1] 646235611
BSFG_03591
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
648586622
HMPREF9553_02846
AMP-bind ing
enzyme
[Escherichia coli
MS 200-1]
647508129
HMPREF0220_0229
response
regulator
[Clostridium
difficile NAP08]
645274141
Bfra3_010100001149
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
651361276
HMPREF1018_00158
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647531299
HMPREF0219_3297
response
regulator
[Clostridium
difficile NAP07]
646237176
CSBG_00519
alkaline
phosphatase
synthesis
transcriptional
regulatory
protein phoP
[Clostridium sp.
7_2_43FAA]
651346676
HMPREF0993_02261
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
646269325
BSHG_00747
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
647884886
HMPREF0101_01946
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
646270233
BSHG_01644
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5] 643098430
BACEGG_03199
SSS sodium
solute
transporter
superfamily
[Bacteroides
eggerthii DSM
20697]
646896937
LRHM_1223
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644391958
HMPREF0539_1325
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
651678939
HMPREF9418_1481
beta-lactamase
[Neisseria
macacae ATCC
33926]
650041439
HMPREF1016_01038
sodium
symporter
family protein
[Bacteroides
eggerthii
1_2_48FAA]
651362043
HMPREF1018_00915
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647885748
HMPREF0101_02798
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
651382443
HMPREF0404_01697
hypothetical
prote in
[Fusobacterium
sp. 21_1A]
645354015
PrD11_010100003381
two component
transcriptional
regulator
[Fusobacterium
sp. D11]
647826024
HMPREF0406_01019
OmpR family
response
regulator
[Fusobacterium
sp. 3_1_33]
646257610
FSDG_02023
response
regulator arlR
[Fusobacterium
sp. 7_1]
645965242
FulcA4_010100002977
two component
transcriptional
regulator
[Fusobacterium
ulcerans ATCC
49185]
646284703
FVAG_00491
OmpR family
response
regulator
[Fusobacterium
varium ATCC
27725]
651355328
HMPREF0401_02049
DNA-bind ing
response
regulator ArlR
[Fusobacterium
sp. 11_3_2]
647998970
HMPREF0400_01462
DNA-bind ing
response
regulator YycF
[Fusobacterium
sp. 1_1_41FAA]
651357959
HMPREF1017_01987
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
651370551
HMPREF0127_01444
hypothetical
prote in
[Bacteroides sp.
1_1_30]
646215335
BSBG_03617
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
650005922
HMPREF9011_04415
hypothetical
prote in
[Bacteroides sp.
3_1_40A]
646220753
BSAG_04100
conserved
hypothetical
prote in
[Bacteroides sp.
D1]
643098299
BACEGG_03068
hypothetical
prote in
[Bacteroides
eggerthii DSM
20697]
646214608
BSBG_02896
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
648588492
HMPREF9553_04717
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 200-1]
647940132
HMPREF0485_02982
acyl-acyl-carrier
prote in
synthetase
[Klebsiella sp.
1_1_55]
651550411
HMPREF9538_04174
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Klebsiella sp.
MS 92-3]
646207788
ESAG_01513
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648563815
HMPREF9530_01258
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 21-1] 648549133
HMPREF9531_02115
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 45-1]
648598291
HMPREF9549_03360
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 185-1]
648557881
HMPREF9534_05520
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 69-1]
646227021
BSCG_05508
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
643120727
BACDOR_01636
hypothetical
prote in
[Bacteroides
dorei DSM
17855]
647441463
CW3_3748 TraG
family protein
[Bacteroides
xylanisolvens
SD CC 1b]
648894488
HMPREF0106_04028
TraG family
prote in
[Bacteroides sp.
D22]
646288220
HMPREF0619_02746
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
647879821
HMPREF0102_01696
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
648909105
HMPREF9008_04719
TraG family
prote in
[Bacteroides sp.
20_3]
647886482
HMPREF0101_03527
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
645278618
Bfra3_010100023517
putative
mobilization
prote in
[Bacteroides
fragilis 3_1_12]
645282960
B2_010100021036
putative
mobilization
prote in
[Bacteroides sp.
2_1_7]
648889389
HMPREF0104_03225
TraG family
prote in
[Bacteroides sp.
3_1_19]
643156167
PRABACTJOHN_01796
hypothetical
prote in
[Parabacteroides
johnsonii DSM
18315]
647458859
CW1_4453 TraG
family protein
[Bacteroides
ovatus SD CC
2a]
651363951
HMPREF1018_02798
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
643099979
BACPEC_00978
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Bacteroides
pectinophilus
ATCC 43243]
644100326
COPCOM_00045
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
comes ATCC
27758]
643915948
Cbac1_010100012135
two component
transcriptional
regulator
[Clostridiales
sp. 1_7_47FAA] 650015994
HMPREF0996_00537
response
regulator
receiver
domain-conta in ing
prote in
[Lachnospiraceae
bacterium sp.
5_1_63FAA]
650080818
HMPREF9475_00124
winged helix
family Two
component
transcriptional
regulator
[Clostridium
symbiosum
WAL-14673]
650074085
HMPREF9488_02064
KDP operon
transcriptional
regulatory
protein KdpE
[Coprobacillus
sp. 29_1]
651330768
HMPREF0988_00196
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
650593337
CL2_04920
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridiales
sp. SSC/2]
651367222
HMPREF1025_01108
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
644207991
CLOSTMETH_01946
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
methylpentosum
R2, DSM 5476]
650015966
HMPREF0996_00509
response
regulator
receiver
domain-conta in ing
prote in
[Lachnospiraceae
bacterium sp.
5_1_63FAA] 650270898
HMPREF9406_0650
KDP operon
transcriptional
regulatory
protein KdpE
[Clostridium sp.
HGF2]
651343625
HMPREF0994_06162
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650076586
HMPREF9474_00653
winged helix
family Two
component
transcriptional
regulator
[Clostridium
symbiosum
WAL-14163]
651330765
HMPREF0988_00193
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651349473
HMPREF0992_01642
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
646036788
ChatD1_010100012309
two component
transcriptional
regulator
[Clostridium
hathewayi DSM
13479]
646240937
MBAG_00774
conserved
hypothetical
prote in
[Coprobacillus
sp. D7]
643101664
BACPEC_02665
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Bacteroides
pectinophilus
ATCC 43243]
650049331
HMPREF1026_02002
winged helix
family Two
component
transcriptional
regulator
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
646040207
ChatD1_010100029539
two component
transcriptional
regulator
[Clostridium
hathewayi DSM
13479]
651343322
HMPREF0994_05863
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
651312557
HMPREF0240_01510
KDP operon
transcriptional
regulatory
protein KdpE
[Clostridium sp.
D5]
646257657
FSDG_02070
predicted
prote in
[Fusobacterium
sp. 7_1]
645354066
PrD11_010100003636
hypothetical
prote in
[Fusobacterium
sp. D11]
651362114
HMPREF1018_00984
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
651382491
HMPREF0404_01745
hypothetical
prote in
[Fusobacterium
sp. 21_1A]
647882922
HMPREF0101_00013
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
650546775
EUR_08760
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
rectale DSM
17629]
645274204
Bfra3_010100001454
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
646269260
BSHG_00684
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
643923060
HcinC1_010100008193
two-component
system
response
regulator
[Helicobacter
cinaedi CCUG
18818]
643921314
HcanM9_010100007794
response
regulator OMPR
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
643925271
HpulM9_010100006915
response
regulator OMPR
[Helicobacter
pullorum MIT
98-5489]
646263929
HRAG_01598
two-component
system
response
regulator
[Helicobacter
bilis ATCC
43879]
646265858
HWAG_01225
response
regulator ompR
[Helicobacter
winghamensis
ATCC BAA-430]
645968057
FgonA2_010100000355
chloride channel
prote in
[Fusobacterium
gonidiaformans
ATCC 25563]
645961304
F3_010100004610
chloride channel
prote in
[Fusobacterium
sp. 3_1_5R]
648522123
HMPREF9552_02290
acyl-[acyl
carrier protein]
synthetase/2-acylglycerophosphoethanolamine
acyltransferase
[Escherichia coli
MS 198-1]
645963812
FuD12_010100007350
chloride channel
prote in
[Fusobacterium
sp. D12]
646224577
BSCG_03096
d ipeptidyl
peptidase IV
[Bacteroides sp.
2_2_4]
647450514
CUY_3404
d ipeptidyl
peptidase IV
N-terminal
domain prote in
[Bacteroides
ovatus SD CMC
3f]
648903066
HMPREF9010_00648
putative
d ipeptidyl
aminopeptidase
IV [Bacteroides
sp. 3_1_23]
650578818
CK1_37380
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. SR1/5]
646005160
BacD2_010100012441
d ipeptidyl
peptidase IV
[Bacteroides sp.
D2]
651356487
HMPREF1017_00530
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
650084465
HMPREF9475_03738
KDP operon
transcriptional
regulatory
protein KdpE
[Clostridium
symbiosum
WAL-14673]
650077344
HMPREF9474_01403
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
644158025
RUMHYD_03700
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
651329278
HMPREF0990_01497
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
651343627
HMPREF0994_06164
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
651311342
HMPREF0240_00291
DNA-bind ing
response
regulator KdpE
[Clostridium sp.
D5]
650593354
CL2_05090
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridiales
sp. SSC/2]
644181641
CLOSTASPAR_06259
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
asparagiforme
DSM 15981]
643910179
BbifN4_010100003645
acyltransferase
3
[Bifidobacterium
bifidum NCIMB
41171]
650590076
ES1_13950
hypothetical
prote in
[Eubacterium
siraeum
V10Sc8a]
643138945
DESPIG_01728
Histidine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Desulfovibrio
piger ATCC
29098]
650552813
EUS_07170
NfeD-like.
[Eubacterium
siraeum 70/3]
648928143
HMPREF0326_02850
conserved
hypothetical
prote in
[Desulfovibrio
sp. 3_1_syn3]
650011008
HMPREF1007_03208
ABC transporter
[Bacteroides sp.
4_1_36]
647937874
HMPREF0485_00755
n itrite extrusion
prote in 1
[Klebsiella sp.
1_1_55] 647874190
HMPREF0103_0127
polysaccharide
export outer
membrane
prote in
[Bacteroides sp.
2_1_33B]
650061438
HMPREF0864_02014
n itrite
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
651550535
HMPREF9538_04298
n itrite extrusion
prote in 1
[Klebsiella sp.
MS 92-3]
650549868
ERE_10560
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
recta le M104/1]
647896993
HMPREF0969_00925
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
644391080
HMPREF0539_0455
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
646898498
LRHM_2757
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
650522730
AL1_26840
hypothetical
prote in
[Alistipes shahii
WAL 8301]
650013809
HMPREF0983_02402
DNA-bind ing
response
regulator
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650273641
HMPREF9406_0406
putative
response
regulator
protein GraR
[Clostridium sp.
HGF2]
651340845
HMPREF0994_03417
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
648922818
HMPREF0189_02304
putative cationic
amino acid
transporter
[Burkholderiales
bacterium
1_1_47]
648924939
HMPREF0189_02006
cytochrome c
assembly family
prote in
[Burkholderiales
bacterium
1_1_47]
645959761
BcroD2_010100009592
two component
transcriptional
regulator,
winged helix
family protein
[Butyrivibrio
crossotus DSM
2876]
650008092
HMPREF1007_00334
glycosyl
hydrolase family
3 C terminal
domain-conta in ing
prote in
[Bacteroides sp.
4_1_36]
647897641
HMPREF0969_01564
glycosyl
hydrolase family
3 prote in
[Bacteroides sp.
D20]
650012858
HMPREF0983_01406
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650580226
CK5_13910
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
obeum A2-162]
651554032
HMPREF9439_01579
cytochrome c
assembly
prote in
[Parasutterella
excrementihominis
YIT 11859]
648531811
HMPREF9540_00427
Hsp20/a lpha
crystallin family
prote in
[Escherichia coli
MS 115-1]
651345459
HMPREF0993_01075
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
650351919
HMPREF9443_01699
citrate
transporter
[Phascolarctobacterium
sp. YIT 12067]
650019999
HMPREF1004_01459
integral
membrane
prote in
[Ralstonia sp.
5_7_47FAA]
643097117
BACEGG_01886
hypothetical
prote in
[Bacteroides
eggerthii DSM
20697]
651553279
HMPREF9439_00826
putative
membrane
prote in
[Parasutterella
excrementihominis
YIT 11859]
648928234
HMPREF0326_02941
conserved
hypothetical
prote in
[Desulfovibrio
sp. 3_1_syn3]
643157625
PRABACTJOHN_03254
hypothetical
prote in
[Parabacteroides
johnsonii DSM
18315]
650273303
HMPREF9406_3588
hypothetical
prote in
[Clostridium sp.
HGF2]
647855659
HMPREF0847_00203
conserved
hypothetical
prote in
[Streptococcus
sp. 2_1_36FAA]
647995643
HMPREF0405_01419
conserved
hypothetical
prote in
[Fusobacterium
sp. 3_1_27]
651513153
HMPREF9412_5059
ABC superfamily
ATP binding
cassette
transporter
[Paenibacillus
sp. HGF5]
645277230
Bfra3_010100016598
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
650086058
HMPREF9459_01097
ABC transporter
permease
[Streptococcus
anginosus
1_2_62CV]
647367686
EDWATA_00417
putative
membrane
prote in
[Edwardsiella
tarda ATCC
23685]
650088427
HMPREF9464_01598
winged helix
family Two
component
transcriptional
regulator
[Sutterella
wadsworthensis
3_1_45B]
650062342
HMPREF0864_02909
SH3
domain-conta in ing
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
651539958
HMPREF9445_01033
glycosyltransferase,
group 2 family
prote in
[Bacteroides
clarus YIT
12056]
650561199
GPA_16530
Protein of
unknown
function
(DUF1648).
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
648927678
HMPREF0326_02389
collagen
alpha-1(III)
chain
[Desulfovibrio
sp. 3_1_syn3]
646211612
ESAG_06860
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
647369522
EDWATA_02253
conserved
hypothetical
prote in
[Edwardsiella
tarda ATCC
23685]
645277377
Bfra3_010100017347
putative
glycosyltransferase
[Bacteroides
fragilis 3_1_12]
643922306
HcinC1_010100004280
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
646266226
HWAG_01590
conserved
hypothetical
prote in
[Helicobacter
winghamensis
ATCC BAA-430]
648926600
HMPREF0326_01329
arg in ine/orn ith ine
antiporter
[Desulfovibrio
sp. 3_1_syn3]
646109916
HMPREF0494_2171
conserved
hypothetical
prote in
[Lactobacillus
antri DSM
16041]
651553853
HMPREF9439_01400
hypothetical
prote in
[Parasutterella
excrementihominis
YIT 11859] 650521699
AL1_13920
hypothetical
prote in
[Alistipes shahii
WAL 8301]
650014816
HMPREF0983_03519
putative AP
endonuclease,
family 2
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650046057
HMPREF1023_01716
luxR family
Bacterial
regulatory
prote in
[Eggerthella sp.
1_3_56FAA]
644207829
CLOSTMETH_01784
Uncharacterized
prote in
conserved in
bacteria
[Clostridium
methylpentosum
R2, DSM 5476] 643145410
PROVALCAL_01086
Protein of
unknown
function
(DUF1434).
[Providencia
alcalifaciens
DSM 30120]
644165615
BACCELL_00778
hypothetical
prote in
[Bacteroides
cellulosilyticus
DSM 14838]
651332154
HMPREF0988_01564
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
651340292
HMPREF0994_02865
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
651518774
HMPREF9412_0243
conserved
domain prote in
[Paenibacillus
sp. HGF5]
644181889
CLOSTASPAR_06507
CAAX amino
terminal
protease family.
[Clostridium
asparagiforme
DSM 15981]
650062478
HMPREF0864_03041
drug resistance
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
644168895
BACCELL_04059
hypothetical
prote in
[Bacteroides
cellulosilyticus
DSM 14838]
651344936
HMPREF0993_00565
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA] 651679915
HMPREF9418_2435
DnaJ domain
prote in
[Neisseria
macacae ATCC
33926] 645276438
Bfra3_010100012620
RagB/SusD
domain-conta in ing
prote in
[Bacteroides
fragilis 3_1_12]
647369804
EDWATA_02535
putative
membrane
prote in
[Edwardsiella
tarda ATCC
23685]
644155938
RUMHYD_01611
hypothetical
protein [Blautia
hydrogenotrophica
DSM 10507] 648926222
HMPREF0326_00952
hypothetical
prote in
[Desulfovibrio
sp. 3_1_syn3]
650011985
HMPREF0983_00460
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
643138627
DESPIG_01410
Cation/multidrug
efflux pump
[Desulfovibrio
piger ATCC
29098]
646261819
OFBG_01605
n itrogen
fixation prote in
VnfA
[Oxalobacter
formigenes
OXCC13]
651544231
HMPREF9446_01977
TonB-dependent
receptor plug
domain prote in
[Bacteroides
fluxus YIT
12057]
644144984
BACCOPRO_01314
Glycosyltransferases,
probably
involved in cell
wall biogenesis
[Bacteroides
coprophilus
DSM 18228]
645962494
FuD12_010100000640
hypothetical
prote in
[Fusobacterium
sp. D12]
646240110
CSBG_03414
CAAX amino
terminal
protease
[Clostridium sp.
7_2_43FAA]
643921062
HcanM9_010100006525
sodium/pro line
permease
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
644096136
PROPEN_00841
putative
2-aminoethylphosphonate
ABC transport
system,
permease
protein [Proteus
penneri ATCC
35198]
644208047
CLOSTMETH_02002
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Clostridium
methylpentosum
R2, DSM 5476]
644100025
PROPEN_04742
ATPases
involved in
chromosome
partition ing
[Proteus penneri
ATCC 35198]
650007926
HMPREF1007_00168
two component
regulator
propeller
[Bacteroides sp.
4_1_36]
647367973
EDWATA_00704
nucleoside
permease NupG
[Edwardsiella
tarda ATCC
23685]
646304708
HMPREF0026_02159
GGDEF family
prote in
[Acinetobacter
junii SH205]
643913698
Cbac1_010100000895
hypothetical
prote in
[Clostridiales
sp. 1_7_47FAA]
650060612
HMPREF0864_01199
hypothetical
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
647450600
CUY_3722
conserved
domain prote in
[Bacteroides
ovatus SD CMC
3f]
644155214
RUMHYD_00887
Transglutaminase-like
superfamily.
[Blautia
hydrogenotrophica
DSM 10507]
648926128
HMPREF0326_00858
sodium/hydrogen
exchanger
family protein
[Desulfovibrio
sp. 3_1_syn3]
650541879
ENC_14850
Predicted
membrane
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
645958449
BcroD2_010100003039
hypothetical
prote in
[Butyrivibrio
crossotus DSM
2876]
647371054
EDWATA_03787
sodium-dependent
symporter
family protein
[Edwardsiella
tarda ATCC
23685]
643145059
PROVALCAL_00734
RND family
e fflux
transporter,
MFP subunit
[Providencia
alcalifaciens
DSM 30120]
651349457
HMPREF0992_01626
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
650573222
RBR_17750
bacterial
peptide chain
release factor 2
(bRF-2)
[Ruminococcus
bromii L2-63]
651337671
HMPREF0994_00257
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650021660
HMPREF1004_03123
multidrug
resistance
transporter,
Bcr/CflA family
[Ralstonia sp.
5_7_47FAA]
650273756
HMPREF9406_2722
conserved
hypothetical
prote in
[Clostridium sp.
HGF2]
648928182
HMPREF0326_02889
polysaccharide
biosynthesis
prote in
[Desulfovibrio
sp. 3_1_syn3]
646226165
BSCG_04670
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
644101287
COPCOM_01006
DnaJ domain.
[Coprococcus
comes ATCC
27758]
646235293
BSFG_03276
predicted
prote in
[Bacteroides sp.
4_3_47FAA]
643139728
DESPIG_02511
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
644156431
RUMHYD_02104
ATP-dependent
metalloprotease
FtsH [Blautia
hydrogenotrophica
DSM 10507]
650578052
CK1_28000
hypothetical
prote in
[Ruminococcus
sp. SR1/5]
646272499
BSHG_03872
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
651677787
HMPREF9418_0349
DNA
topoisomerase
[Neisseria
macacae ATCC
33926]
651680067
HMPREF9418_2581
cell division
protein FtsQ
[Neisseria
macacae ATCC
33926]
643922248
HcinC1_010100003975
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
647896304
HMPREF0969_00252
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
650534252
CLS_23260
hypothetical
prote in
[Clostridium cf.
saccharolyticum
K10]
651371466
HMPREF0127_02351
hypothetical
prote in
[Bacteroides sp.
1_1_30]
648828941
HMPREF9399_1071
conserved
hypothetical
prote in
[Campylobacter
coli JV20]
651515401
HMPREF9412_5766
HAMP domain
prote in
[Paenibacillus
sp. HGF5]
650043165
HMPREF1016_02743
carbohydrate
b ind ing module
[Bacteroides
eggerthii
1_2_48FAA]
651334355
HMPREF0991_00526
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
648591976
HMPREF9551_02755
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 196-1]
645350912
E4_010100011223
putative
transporter
subunit:
perip lasmic-b ind ing
component o f
ABC superfamily
prote in
[Escherichia sp.
4_1_40B]
646207008
ESAG_00741
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648555338
HMPREF9534_02975
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 69-1]
648545848
HMPREF9543_03901
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 146-1]
648526979
HMPREF9536_01422
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 84-1]
651329612
HMPREF0990_01822
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
645347335
ShiD9_010100015975
hypothetical
protein [Shigella
sp. D9]
651337342
HMPREF0991_03462
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650048856
HMPREF1026_01537
hypothetical
prote in
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
648582525
HMPREF9547_03733
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 175-1]
646288175
HMPREF0619_02701
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
648550815
HMPREF9531_03800
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 45-1]
648538851
HMPREF9548_02336
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 182-1]
648524389
HMPREF9552_04558
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 198-1]
648560493
HMPREF9550_02540
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 187-1]
648598564
HMPREF9549_03633
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 185-1]
648574982
HMPREF9541_01463
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 116-1]
648573396
HMPREF9535_04981
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 78-1]
648588952
HMPREF9553_05177
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 200-1]
648533351
HMPREF9540_01968
bacterial
extracellular
so lu te-b ind ing
protein, family
5 [Escherichia
coli MS 115-1]
643145438
PROVALCAL_01114
ABC-type Fe3
-siderophore
transport
system,
permease
component
[Providencia
alcalifaciens
DSM 30120]
643154667
PRABACTJOHN_00296
hypothetical
prote in
[Parabacteroides
johnsonii DSM
18315]
651545687
HMPREF9446_03433
protein AraJ
[Bacteroides
fluxus YIT
12057]
650042862
HMPREF1016_02451
major facilitator
superfamily
transporter
[Bacteroides
eggerthii
1_2_48FAA]
646273068
BSHG_04437
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
648909847
HMPREF9008_00361
putative outer
membrane
prote in
[Bacteroides sp.
20_3]
647896717
HMPREF0969_00660
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
643097732
BACEGG_02501
Arabinose efflux
permease
[Bacteroides
eggerthii DSM
20697]
647446644
CUO_0327
putative
membrane
prote in
[Enterococcus
faecalis PC4.1]
644392857
HMPREF0539_2214
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
650567474
ROI_34950
Predicted
permease.
[Roseburia
intestinalis
M 50/1]
646896508
LRHM_0799
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644391571
HMPREF0539_0943
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
650570767
RO1_32240
Predicted
permease.
[Roseburia
intestinalis
XB6B4]
650061804
HMPREF0864_02378
prote in-P-II
uridylyltransferase
[Enterobacteriaceae
bacterium
9_2_54FAA]
646273248
BSIG_00108
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
651315025
HMPREF0240_03987
sodium/proton
antiporter ShaA
[Clostridium sp.
D5]
648882467
HMPREF9007_01216
TolQ-type
transporter
[Bacteroides sp.
1_1_14]
647368895
EDWATA_01626
disulfide bond
formation
protein B
[Edwardsiella
tarda ATCC
23685]
650560030
FPR_29340
Esterase/lipase
[Faecalibacterium
prausnitzii
SL3/3]
644156873
RUMHYD_02546
Bacterial
membrane
protein YfhO.
[Blautia
hydrogenotrophica
DSM 10507]
644158016
RUMHYD_03691
D-a lanyl-D-a lan ine
carboxypeptidase
[Blautia
hydrogenotrophica
DSM 10507]
651567121
HMPREF9413_1823
transporter,
major facilitator
family protein
[Paenibacillus
sp. HGF7]
650023008
HMPREF1004_04461
transcriptional
regulator, LysR
family
[Ralstonia sp.
5_7_47FAA]
648828402
HMPREF9399_0546
amino acid ABC
superfamily ATP
binding cassette
transporter,
b ind ing prote in
[Campylobacter
coli JV20]
646265967
HWAG_01331
cdp-diacylglycerol-phosphatidyltransferase
[Helicobacter
winghamensis
ATCC BAA-430]
646248071
CSAG_04396
conserved
hypothetical
prote in
[Citrobacter sp.
30_2]
643145266
PROVALCAL_00941
Arabinose efflux
permease
[Providencia
alcalifaciens
DSM 30120] 648925493
HMPREF0326_00229
putative
membrane
prote in
[Desulfovibrio
sp. 3_1_syn3]
643140076
DESPIG_02859
Arabinose efflux
permease
[Desulfovibrio
piger ATCC
29098]
644177906
CLOSTASPAR_02521
diguanylate
cyclase (GGDEF)
domain
[Clostridium
asparagiforme
DSM 15981]
650059422
HMPREF0864_00037
cytochrome c
[Enterobacteriaceae
bacterium
9_2_54FAA]
651341629
HMPREF0994_04198
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1] 644180825
CLOSTASPAR_05442
hypothetical
prote in
[Clostridium
asparagiforme
DSM 15981]
648523482
HMPREF9552_03650
conserved
hypothetical
prote in
[Escherichia coli
MS 198-1]
648562833
HMPREF9530_00275
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
646206404
ESAG_00155
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
645345598
ShiD9_010100007279
putative
autoagglutination
protein [Shigella
sp. D9]
648558722
HMPREF9550_00769
conserved
hypothetical
prote in
[Escherichia coli
MS 187-1]
648555665
HMPREF9534_03302
conserved
hypothetical
prote in
[Escherichia coli
MS 69-1]
648537326
HMPREF9548_00810
hypothetical
prote in
[Escherichia coli
MS 182-1]
648547736
HMPREF9531_00718
conserved
hypothetical
prote in
[Escherichia coli
MS 45-1]
647368175
EDWATA_00906
prote in-P-II
uridylyltransferase
[Edwardsiella
tarda ATCC
23685] 647856300
HMPREF0847_00843
ABC transporter
permease/ATP-binding
prote in
[Streptococcus
sp. 2_1_36FAA]
647939494
HMPREF0485_02353
soluble aldose
sugar
dehydrogenase
yliI [Klebsiella
sp. 1_1_55]
647883376
HMPREF0101_00462
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
645279885
B2_010100005620
hypothetical
prote in
[Bacteroides sp.
2_1_7]
650568824
RO1_09730
Transcriptional
regulator
containing an
amidase domain
and an
AraC-type
DNA-bind ing
HTH domain
[Roseburia
intestinalis
XB6B4]
645274738
Bfra3_010100004121
putative
permease
component o f
ABC transporter
[Bacteroides
fragilis 3_1_12]
650566291
ROI_21290
Transcriptional
regulator
containing an
amidase domain
and an
AraC-type
DNA-bind ing
HTH domain
[Roseburia
intestinalis
M 50/1]
648889056
HMPREF0104_02893
outer
membrane
prote in
[Bacteroides sp.
3_1_19]
646268769
BSHG_00198
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5] 651362731
HMPREF1018_01597
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
643157887
PRABACTJOHN_03517
hypothetical
prote in
[Parabacteroides
johnsonii DSM
18315]
644391469
HMPREF0539_0843
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
651350742
HMPREF0987_00263
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
646305419
HMPREF0026_02860
riboflavin
biosynthesis
protein RibF
[Acinetobacter
junii SH205]
650533133
CLS_09200
hypothetical
prote in
[Clostridium cf.
saccharolyticum
K10]
644146645
BACCOPRO_02976
N-acetylmuramoyl-L-a lan ine
amidase
[Bacteroides
coprophilus
DSM 18228]
647369234
EDWATA_01965
hemin ABC
transporter,
permease
prote in
[Edwardsiella
tarda ATCC
23685]
647937786
HMPREF0485_00667
multiple sugar
transport
system
permease
[Klebsiella sp.
1_1_55]
644144802
BACCOPRO_01132
hypothetical
prote in
[Bacteroides
coprophilus
DSM 18228]
650541849
ENC_14510
ABC-type
uncharacterized
transport
system,
permease
component
[Enterobacter
cloacae cloacae
NCTC 9394]
646304295
HMPREF0026_01762
GGDEF
domain-conta in ing
prote in
[Acinetobacter
junii SH205]
643921452
HcanM9_010100008473
hypothetical
prote in
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
644355609
HMPREF0352_2647
Lysyl-tRNA
synthetase
(class II)
[Enterococcus
faecium
TX1330]
644393507
HMPREF0539_2860
amino acid ABC
superfamily ATP
binding cassette
transporter,
b ind ing prote in
[Lactobacillus
rhamnosus
LMS2-1]
647938769
HMPREF0485_01645
hypothetical
prote in
[Klebsiella sp.
1_1_55]
648927260
HMPREF0326_01973
phospho-N-acetylmuramoyl-pentapeptide-
transferase
[Desulfovibrio
sp. 3_1_syn3]
646110909
HMPREF0518_0932
conserved
hypothetical
prote in
[Lactobacillus
helveticus DSM
20075]
644184655
CATMIT_02396
hypothetical
prote in
[Catenibacterium
mitsuokai DSM
15897]
643147926
PROVALCAL_03613
Arabinose efflux
permease
[Providencia
alcalifaciens
DSM 30120]
647450447
CUY_1619
hypothetical
prote in
[Bacteroides
ovatus SD CMC
3f]
644184317
CATMIT_02058
g lu tamine-- fructose-6-phosphate
transaminase
[Catenibacterium
mitsuokai DSM
15897]
650559697
FPR_25630 K
-dependent Na
/Ca exchanger
re la ted-prote in
[Faecalibacterium
prausnitzii
SL3/3]
651338222
HMPREF0994_00802
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
643138732
DESPIG_01515
Uncharacterized
membrane
prote in ,
required for
N- linked
glycosylation
[Desulfovibrio
piger ATCC
29098]
643156689
PRABACTJOHN_02318
Na /H
antiporter
[Parabacteroides
johnsonii DSM
18315]
644155148
RUMHYD_00821
Protein of
unknown
function
(DUF1393).
[Blautia
hydrogenotrophica
DSM 10507]
650271811
HMPREF9406_1382
ABC
transporter,
ATP-bind ing
prote in
[Clostridium sp.
HGF2]
650544017
ENC_41870
Arabinose efflux
permease
[Enterobacter
cloacae cloacae
NCTC 9394]
651315568
HMPREF0240_04526
sodium/proton
antiporter ShaA
[Clostridium sp.
D5]
651358654
HMPREF1017_02673
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
646896226
LRHM_0551
ABC transporter
substrate
b ind ing
component
[Lactobacillus
rhamnosus GG,
ATCC 53103]
651571392
HMPREF9413_5141
hypothetical
prote in
[Paenibacillus
sp. HGF7]
650274461
HMPREF9406_1621
putative
ferrichrome
transport
system
permease
protein FhuG
[Clostridium sp.
HGF2]
650353917
HMPREF9444_01519
exodeoxyribonuclease
V, alpha subunit
[Succinatimonas
hippei YIT
12066]
644161227
HOLDEFILI_02971
Uncharacterized
conserved
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
651540249
HMPREF9445_01325
TonB-dependent
receptor plug
domain prote in
[Bacteroides
clarus YIT
12056]
648556808
HMPREF9534_04446
transporter,
major facilitator
family protein
[Escherichia coli
MS 69-1]
651351227
HMPREF0987_00746
precorrin-2
C20-methyltransferase
[Lachnospiraceae
bacterium
9_1_43BFAA]
650576263
CK1_06500
precorrin-2
C20-methyltransferase
/cobalt-factor II
C20-methyltransferase
[Ruminococcus
sp. SR1/5]
646289081
HMPREF0619_03593
conserved
hypothetical
prote in
[Parabacteroides
sp. D13]
650587698
ENT_15200
carbohydrate
ABC transporter
membrane
protein 2, CUT1
family (TC
3.A.1.1.-)
[Enterococcus
sp. 7L76]
644293268
HMPREF0348_0105
sugar ABC
superfamily ATP
binding cassette
transporter,
membrane
prote in
[Enterococcus
faecalis
TX0104]
644392932
HMPREF0539_2288
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
651550195
HMPREF9538_03958
putative
membrane
prote in
[Klebsiella sp.
MS 92-3]
646270525
BSHG_01934
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
648889338
HMPREF0104_03174
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_19]
645282388
B2_010100018153
hypothetical
prote in
[Bacteroides sp.
2_1_7]
651366751
HMPREF1025_00648
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
650570082
RO1_23840
StbA protein.
[Roseburia
intestinalis
XB6B4]
647877277
HMPREF0103_3161
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
651333534
HMPREF0988_02914
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
647448797
CUW_0252
transporter,
major facilitator
family protein
[Turicibacter
sanguinis
PC909]
644182194
CLOSTASPAR_06812
Predicted
membrane
meta l-b ind ing
prote in
[Clostridium
asparagiforme
DSM 15981]
651678351
HMPREF9418_0906
hypothetical
prote in
[Neisseria
macacae ATCC
33926]
644317643
HMPREF0548_0052
conserved
hypothetical
prote in
[Lactobacillus
ultunensis DSM
16047]
647997559
HMPREF0400_00025
conserved
hypothetical
prote in
[Fusobacterium
sp. 1_1_41FAA]
646258556
OFAG_00533
xanth ine/uracil/vitamin
C permease
[Oxalobacter
formigenes
HOxBLS]
644183810
CATMIT_01549
hypothetical
prote in
[Catenibacterium
mitsuokai DSM
15897]
651567294
HMPREF9413_3548
transporter,
major facilitator
family protein
[Paenibacillus
sp. HGF7]
650351334
HMPREF9443_01114
conserved
domain prote in
[Phascolarctobacterium
sp. YIT 12067] 647826153
HMPREF0406_01148
polysaccharide
biosynthesis
prote in
[Fusobacterium
sp. 3_1_33]
643122844
BACDOR_03755
hypothetical
prote in
[Bacteroides
dorei DSM
17855]
651539874
HMPREF9445_00950
protein AraJ
[Bacteroides
clarus YIT
12056]
644391415
HMPREF0539_0789
ABC superfamily
ATP binding
cassette
transporter,
permease
prote in
[Lactobacillus
rhamnosus
LMS2-1]
647856728
HMPREF0847_01266
sodium
transporter
[Streptococcus
sp. 2_1_36FAA]
644358646
HMPREF0492_0928
ABC superfamily
ATP binding
cassette
transporter,
g lu tamine-b ind ing
prote in
[Lactobacillus
acidophilus
ATCC 4796]
650320838
HMPREF9420_2032
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
651364680
HMPREF1018_03521
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647886079
HMPREF0101_03127
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16] 646897892
LRHM_2165
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
651346621
HMPREF0993_02206
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA] 650555973
FP2_16130
Predicted
membrane
prote in
[Faecalibacterium
prausnitzii
L2-6]
647938366
HMPREF0485_01242
hypothetical
prote in
[Klebsiella sp.
1_1_55] 644154795
RUMHYD_00468
ABC-type
transport
system involved
in cytochrome
bd biosynthesis,
ATPase and
permease
components
[Blautia
hydrogenotrophica
DSM 10507]
650561206
GPA_16640
g lutamate-1-semia ldehyde
2,1-aminomutase
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
651337809
HMPREF0994_00392
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
648905331
HMPREF9010_04119
putative
pectinesterase/pectate
lyase protein
[Bacteroides sp.
3_1_23]
644147319
BACCOPRO_03650
hypothetical
prote in
[Bacteroides
coprophilus
DSM 18228]
643136159
COLSTE_01523
cell
elongation-specific
peptidoglycan
biosynthesis
regulator RodA
[Collinsella
stercoris DSM
13279]
650029167
HMPREF1011_02591
polysaccharide
biosynthesis
prote in
[Anaerostipes
sp. 3_2_56FAA]
647371174
EDWATA_03907
AsmA family
prote in
[Edwardsiella
tarda ATCC
23685]
646265867
HWAG_01234
deth iob iotin
synthetase
[Helicobacter
winghamensis
ATCC BAA-430]
651557704
HMPREF9442_02442
urea transporter
[Paraprevotella
xylaniphila YIT
11841]
644101423
COPCOM_01142
Mg2
transporter
(mgtE)
[Coprococcus
comes ATCC
27758]
648925507
HMPREF0326_00243
carbon
monoxide-induced
hydrogenase,
membrane
anchor subunit
[Desulfovibrio
sp. 3_1_syn3]
643099131
BACPEC_00129
TRAP
transporter,
DctM subunit
[Bacteroides
pectinophilus
ATCC 43243]
651545814
HMPREF9446_03560
GDSL-like
prote in
[Bacteroides
fluxus YIT
12057]
644166787
BACCELL_01950
Permeases of
the
drug/metabolite
transporter
(DMT)
superfamily
[Bacteroides
cellulosilyticus
DSM 14838]
643917894
Cbac1_010100021817
cytosine
permease
[Clostridiales
sp. 1_7_47FAA]
650350420
HMPREF9443_00200
hypothetical
prote in
[Phascolarctobacterium
sp. YIT 12067]
643918098
Cbac1_010100022837
type II secretion
system protein
[Clostridiales
sp. 1_7_47FAA]
646238919
CSBG_02258
conserved
hypothetical
prote in
[Clostridium sp.
7_2_43FAA]
651518159
HMPREF9412_0421
putative
sporulation
protein YpjB
[Paenibacillus
sp. HGF5]
644207193
CLOSTMETH_01146
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
644180263
CLOSTASPAR_04880
Arabinose efflux
permease
[Clostridium
asparagiforme
DSM 15981]
650013381
HMPREF0983_01948
putative
transporter
[Erysipelotrichaceae
bacterium sp.
3_1_53]
650088162
HMPREF9464_01344
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
650087050
HMPREF9464_00263
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
650085033
HMPREF9459_00078
hypothetical
prote in
[Streptococcus
anginosus
1_2_62CV]
643919812
HcanM9_010100000276
two-component
response
regulator
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
644435795
HMPREF0535_0965
LIVCS family
branched chain
amino
acid:cation
symporter
[Lactobacillus
reuteri MM2-3]
644345142
HMPREF0534_2010
LIVCS family
branched chain
amino
acid:cation
symporter
[Lactobacillus
reuteri
CF48-3A]
648528486
HMPREF9536_02931
transporter,
major facilitator
family protein
[Escherichia coli
MS 84-1]
651369922
HMPREF0127_00818
hypothetical
prote in
[Bacteroides sp.
1_1_30]
644161179
HOLDEFILI_02923
Chromate
transport
protein ChrA
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
648541105
HMPREF9548_04591
transporter,
major facilitator
family protein
[Escherichia coli
MS 182-1]
651361274
HMPREF1018_00156
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
648894094
HMPREF0106_03631
MATE efflux
family protein
[Bacteroides sp.
D22]
651551839
HMPREF9538_05603
transporter,
major facilitator
family protein
[Klebsiella sp.
MS 92-3]
648572378
HMPREF9535_03962
transporter,
major facilitator
family protein
[Escherichia coli
MS 78-1]
648546545
HMPREF9543_04599
site-specific
recombinase,
phage integrase
family
[Escherichia coli
MS 146-1]
648572059
HMPREF9535_03643
site-specific
recombinase,
phage integrase
family
[Escherichia coli
MS 78-1]
646305420
HMPREF0026_02861
te llurite
resistance
prote in
[Acinetobacter
junii SH205]
643183217
EUBIFOR_00453
ATP-dependent
RNA helicase
DbpA (EC
5.99.1.-)
[Eubacterium
biforme DSM
3989]
644145212
BACCOPRO_01542
PAP2
superfamily.
[Bacteroides
coprophilus
DSM 18228]
650016532
HMPREF0996_01052
hypothetical
prote in
[Lachnospiraceae
bacterium sp.
5_1_63FAA]
648927950
HMPREF0326_02656
conjugal
transfer protein
TraG
[Desulfovibrio
sp. 3_1_syn3] 647938569
HMPREF0485_01445
MFS
transporter,
YNFM family,
membrane
transporter
[Klebsiella sp.
1_1_55]
644176182
CLOSTASPAR_00796
ABC-type sugar
transport
systems,
permease
components
[Clostridium
asparagiforme
DSM 15981]
650059457
HMPREF0864_00072
membrane
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
650046229
HMPREF1023_01888
H antiporter-1
family protein
[Eggerthella sp.
1_3_56FAA]
647782759
HMPREF5045_00213
conserved
hypothetical
prote in
[Lactobacillus
crispatus
125-2-CHN]
651570311
HMPREF9413_5001
putative
membrane
prote in
[Paenibacillus
sp. HGF7]
645278013
Bfra3_010100020500
exported
prote in ,
ATP/GTP-binding
[Bacteroides
fragilis 3_1_12]
648828211
HMPREF9399_0357
polysaccharide
biosynthesis
prote in
[Campylobacter
coli JV20]
648541674
HMPREF9548_05161
TraF-like
prote in
[Escherichia coli
MS 182-1]
643137389
DESPIG_00169
Na /pro line
symporter
[Desulfovibrio
piger ATCC
29098]
644269157
ROSEINA2194_00653
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
650088952
HMPREF9464_02108
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
643922344
HcinC1_010100004470
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
644209340
CLOSTMETH_03297
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
646041470
ChatD1_010100035822
predicted
transcriptional
regulator
[Clostridium
hathewayi DSM
13479]
651341657
HMPREF0994_04220
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
647368309
EDWATA_01040
sodium:solute
symporter
family protein
[Edwardsiella
tarda ATCC
23685]
651515165
HMPREF9412_3870
HAMP domain
prote in
[Paenibacillus
sp. HGF5]
643915953
Cbac1_010100012160
cation
transporter
[Clostridiales
sp. 1_7_47FAA]
644097801
PROPEN_02511
Phosphatidylglycerophosphate
synthase
[Proteus penneri
ATCC 35198]
650088028
HMPREF9464_01212
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
651556540
HMPREF9442_01278
TonB-dependent
receptor
[Paraprevotella
xylaniphila YIT
11841]
650522664
AL1_26000
Hydrogenase 4
membrane
component (E)
[Alistipes shahii
WAL 8301]
650556174
FP2_18570
Esterase/lipase
[Faecalibacterium
prausnitzii
L2-6]
646247627
CSAG_03952
potassium
transporter Kup
[Citrobacter sp.
30_2]
651571056
HMPREF9413_0020
amino acid
permease
[Paenibacillus
sp. HGF7]
651347380
HMPREF0993_02961
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
643928530
Lparp8_010100012669
hypothetical
prote in
[Lactobacillus
paracasei
8700:2]
643138169
DESPIG_00951
Uncharacterized
conserved
prote in
[Desulfovibrio
piger ATCC
29098]
650573097
RBR_16260
Predicted
membrane
prote in
[Ruminococcus
bromii L2-63]
650062167
HMPREF0864_02737
entericidin
EcnA/B family
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
643137546
DESPIG_00326
deth iob iotin
synthase/adenosylmeth ion ine-8-amino-7-oxononanoate
transaminase
[Desulfovibrio
piger ATCC
29098]
650020855
HMPREF1004_02321
signal peptide
prote in
[Ralstonia sp.
5_7_47FAA]
647367548
EDWATA_00279
hypothetical
prote in
[Edwardsiella
tarda ATCC
23685]
651553935
HMPREF9439_01482
putative
membrane
prote in
[Parasutterella
excrementihominis
YIT 11859]
643158778
PRABACTJOHN_04408
Na /H
-d icarboxylate
symporters
[Parabacteroides
johnsonii DSM
18315] 644097111
PROPEN_01819
Predicted
permeases
[Proteus penneri
ATCC 35198]
644169322
BACCELL_04486
hypothetical
prote in
[Bacteroides
cellulosilyticus
DSM 14838]
650588852
ENT_29880
hypothetical
prote in
[Enterococcus
sp. 7L76]
647370288
EDWATA_03019
CAAX amino
protease family
prote in
[Edwardsiella
tarda ATCC
23685]
646041552
ChatD1_010100036226
hypothetical
prote in
[Clostridium
hathewayi DSM
13479]
644270540
ROSEINA2194_02038
Permeases of
the
drug/metabolite
transporter
(DMT)
superfamily
[Roseburia
inulinivorans
DSM 16841]
650019126
HMPREF1004_00579
GGDEF
domain-conta in ing
prote in
[Ralstonia sp.
5_7_47FAA]
643138742
DESPIG_01525
4-amino-4-deoxy-L-arabinose
transferase and
related
glycosyltransferases
of PMT family
[Desulfovibrio
piger ATCC
29098]
650274495
HMPREF9406_1655
TRAP
transporter,
DctM subunit
[Clostridium sp.
HGF2]
643918400
Cbac1_010100024347
sugar ABC
transporter
permease
[Clostridiales
sp. 1_7_47FAA]
651544261
HMPREF9446_02007
polygalacturonase
[Bacteroides
fluxus YIT
12057]
650017184
HMPREF0996_01702
b ind ing-prote in-dependent
transport
system inner
membrane
component
[Lachnospiraceae
bacterium sp.
5_1_63FAA]
646006427
BacD2_010100018787
Beta-galactosidase
[Bacteroides sp.
D2]
650063340
HMPREF0864_03896
ribonuclease PH
[Enterobacteriaceae
bacterium
9_2_54FAA]
650198334
HMPREF0623_1042
brp/Blh family
beta-carotene
15,15 '-monooxygenase
[Pediococcus
acidilactici DSM
20284]
647937864
HMPREF0485_00745
n itra te
regulatory
prote in
[Klebsiella sp.
1_1_55]
643923391
HcinC1_010100009851
3-deoxy-D-manno-octu losonic-acid
transferase
[Helicobacter
cinaedi CCUG
18818]
651550155
HMPREF9538_03918
glucose/Sorbosone
dehydrogenase
[Klebsiella sp.
MS 92-3] 651550709
HMPREF9538_04472
general
secretion
pathway protein
F [Klebsiella sp.
MS 92-3]
646038734
ChatD1_010100022102
hypothetical
prote in
[Clostridium
hathewayi DSM
13479]
651313558
HMPREF0240_02523
cadmium-exporting
ATPase
[Clostridium sp.
D5]
647941902
HMPREF0485_04739
amino acid ABC
transporter,
permease
[Klebsiella sp.
1_1_55]
650571918
RBR_02450
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
bromii L2-63] 646240939
MBAG_00776
two-component
system
transcriptional
regulator
[Coprobacillus
sp. D7]
650539785
CCU_16700
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
sp. ART55/1]
644269791
ROSEINA2194_01288
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
644182064
CLOSTASPAR_06682
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
asparagiforme
DSM 15981]
643916363
Cbac1_010100014181
two component
transcriptional
regulator
[Clostridiales
sp. 1_7_47FAA]
644293683
HMPREF0348_0509
response
regulator
[Enterococcus
faecalis
TX0104]
643112764
CLONEX_00270
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridium
nexile DSM
1787]
644228419
EUBHAL_02865
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Eubacterium
hallii DSM 3353] 644178706
CLOSTASPAR_03321
hypothetical
prote in
[Clostridium
asparagiforme
DSM 15981]
650553422
EUS_14430
AraC-type
DNA-bind ing
domain-conta in ing
proteins
[Eubacterium
siraeum 70/3] 648550989
HMPREF9531_03974
putative
dipeptide ABC
transporter,
permease
protein DppC
[Escherichia coli
MS 45-1]
650558694
FPR_14420
AraC-type
DNA-bind ing
domain-conta in ing
proteins
[Faecalibacterium
prausnitzii
SL3/3]
650584779
RTO_28680
AraC-type
DNA-bind ing
domain-conta in ing
proteins
[Ruminococcus
torques L2-14]
648588296
HMPREF9553_04521
putative
dipeptide ABC
transporter,
permease
protein DppC
[Escherichia coli
MS 200-1]
646209847
ESAG_03545
ABC transporter
permease
[Escherichia sp.
3_2_53FAA]
650576006
CK1_03350
AraC-type
DNA-bind ing
domain-conta in ing
proteins
[Ruminococcus
sp. SR1/5]
643121531
BACDOR_02440
Na -dependent
transporters of
the SNF family
[Bacteroides
dorei DSM
17855]
646231845
BSEG_04308 Na
-dependent
transporter
[Bacteroides
dore i
5_1_36/D4]
647885336
HMPREF0101_02393
Na -dependent
transporter
[Bacteroides sp.
2_1_16]
651540609
HMPREF9445_01685
Sodium:neurotransmitter
symporter
family protein
[Bacteroides
clarus YIT
12056]
647438882
CUU_1648
sodium:neurotransmitter
symporter
family protein
[Bacteroides
vulgatus PC510]
646215966
BSBG_04244 Na
-dependent
transporter
[Bacteroides sp.
9_1_42FAA]
650001466
HMPREF9011_00022
Na -dependent
transporter
[Bacteroides sp.
3_1_40A]
645276432
Bfra3_010100012590
putative
sodium-dependent
transporter
[Bacteroides
fragilis 3_1_12]
651546757
HMPREF9538_00518
lipopolysaccharide
export system
protein LptC
[Klebsiella sp.
MS 92-3]
644156163
RUMHYD_01836
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
648894167
HMPREF0106_03705
outer
membrane
prote in
[Bacteroides sp.
D22] 646241239
MBAG_01076
predicted
prote in
[Coprobacillus
sp. D7]
646262004
OFBG_01788
leader
peptidase
[Oxalobacter
formigenes
OXCC13] 650019552
HMPREF1004_01008
ggdef domain
prote in
[Ralstonia sp.
5_7_47FAA]
647489856
HMPREF0281_00749
meth ion ine--tRNA
ligase
[Corynebacterium
ammoniagenes
DSM 20306]
651329542
HMPREF0990_01752
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
644159298
HOLDEFILI_01042
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
647940501
HMPREF0485_03347
hypothetical
prote in
[Klebsiella sp.
1_1_55]
650537852
CC1_26620
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
catus GD/7]
651351319
HMPREF0987_00838
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
650528013
BIL_04020
hypothetical
prote in
[Bifidobacterium
longum longum
F8]
650008912
HMPREF1007_01137
peptidase M16
inactive
domain-conta in ing
prote in
[Bacteroides sp.
4_1_36]
650048926
HMPREF1026_01607
KDP operon
transcriptional
regulatory
protein KdpE
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
650578796
CK1_37130
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
sp. SR1/5]
650583654
RTO_16110
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
torques L2-14]
650580216
CK5_13800
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Ruminococcus
obeum A2-162]
648599993
HMPREF9549_05063
conserved
hypothetical
prote in
[Escherichia coli
MS 185-1]
648586060
HMPREF9553_02283
hypothetical
prote in
[Escherichia coli
MS 200-1]
648571724
HMPREF9535_03308
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
646234141
BSFG_02137 Na
-dependent
transporter
[Bacteroides sp.
4_3_47FAA]
648530239
HMPREF9536_04686
transposase, IS4
family
[Escherichia coli
MS 84-1]
648558321
HMPREF9550_00368
transposase, IS4
family
[Escherichia coli
MS 187-1]
650004974
HMPREF9011_03478
secreted protein
[Bacteroides sp.
3_1_40A]
648542016
HMPREF9543_00068
transposase, IS4
family
[Escherichia coli
MS 146-1]
645968767
FgonA2_010100003988
heavy
meta l-transporting
ATPase
[Fusobacterium
gonidiaformans
ATCC 25563]
646228939
BSEG_01439
conserved
hypothetical
prote in
[Bacteroides
dore i
5_1_36/D4]
648573647
HMPREF9541_00127
transposase, IS4
family
[Escherichia coli
MS 116-1]
646233437
BSFG_01440
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
647889277
HMPREF0105_1672
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_33FAA]
647437736
CUU_1008 YngK
prote in
[Bacteroides
vulgatus PC510]
646212204
BSBG_00529
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
648580001
HMPREF9547_01207
transposase, IS4
family
[Escherichia coli
MS 175-1]
643113370
CLONEX_00876
Adenine specific
DNA methylase
Mod
[Clostridium
nexile DSM
1787]
646266909
ESCG_02217
InsL [Escherichia
sp. 1_1_43]
648589417
HMPREF9551_00195
transposase, IS4
family
[Escherichia coli
MS 196-1]
643101854
BACPEC_02855
Adenine specific
DNA methylase
Mod
[Bacteroides
pectinophilus
ATCC 43243]
648532258
HMPREF9540_00874
transposase, IS4
family
[Escherichia coli
MS 115-1]
645353336
E4_010100023361
putative
transposase
insL for
insertion
sequence IS186
[Escherichia sp.
4_1_40B]
645352053
E4_010100016948
DNA methylase
N -4/ N -6
[Escherichia sp.
4_1_40B]
643916727
Cbac1_010100015988
KDP operon
transcriptional
regulatory
protein KdpE
[Clostridiales
sp. 1_7_47FAA]
647940040
HMPREF0485_02893
su lfonate/n itra te/taurine
transport
system
substrate-b ind ing
prote in
[Klebsiella sp.
1_1_55]
651361089
HMPREF1017_05071
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
646003414
BacD2_010100003649
putative
to lQ-type
transport
prote in
[Bacteroides sp.
D2]
651551256
HMPREF9538_05019
conserved
domain prote in
[Klebsiella sp.
MS 92-3]
648596695
HMPREF9549_01762
putative
dipeptide ABC
transporter,
permease
protein DppC
[Escherichia coli
MS 185-1]
648521659
HMPREF9552_01826
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 198-1]
648537004
HMPREF9548_00488
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 182-1]
648549508
HMPREF9531_02491
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 45-1]
645344230
ShiD9_010100000440
hypothetical
protein [Shigella
sp. D9]
647892213
HMPREF0105_4567
Na -dependent
transporter
[Bacteroides sp.
3_1_33FAA]
646209648
ESAG_03346
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648556383
HMPREF9534_04020
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 69-1]
648546685
HMPREF9543_04739
MASE1 domain
prote in
[Escherichia coli
MS 146-1]
646269757
BSHG_01171 Na
-dependent
transporter
[Bacteroides sp.
3_2_5]
651361547
HMPREF1018_00427
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
648591379
HMPREF9551_02158
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 196-1]
648578616
HMPREF9541_05098
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 116-1]
648572135
HMPREF9535_03719
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 78-1]
648560385
HMPREF9550_02432
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 187-1]
648527205
HMPREF9536_01648
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 84-1]
648595442
HMPREF9549_00508
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 185-1]
648536433
HMPREF9540_05053
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 115-1]
645348753
E4_010100000445
putative inner
membrane
prote in
[Escherichia sp.
4_1_40B]
648589163
HMPREF9553_05388
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 200-1]
648583350
HMPREF9547_04559
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 175-1]
648567566
HMPREF9530_05010
cyclic
diguanylate
phosphodiesterase
domain prote in
[Escherichia coli
MS 21-1]
651336364
HMPREF0991_02514
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
645965099
FulcA4_010100002262
hypothetical
prote in
[Fusobacterium
ulcerans ATCC
49185]
650569158
RO1_13440
hypothetical
prote in
[Roseburia
intestinalis
XB6B4]
650566525
ROI_24090
hypothetical
prote in
[Roseburia
intestinalis
M 50/1]
645963779
FuD12_010100007175
hypothetical
prote in
[Fusobacterium
sp. D12]
647436103
CUU_1828
efflux
transporter,
RND family, MFP
subunit
[Bacteroides
vulgatus PC510]
646234714
BSFG_02703
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
646109266
HMPREF0494_1536
LIVCS family
branched chain
amino
acid:cation
symporter
[Lactobacillus
antri DSM
16041] 650564545
ROI_00740
hypothetical
prote in
[Roseburia
intestinalis
M 50/1]
648586973
HMPREF9553_03197
hypothetical
prote in
[Escherichia coli
MS 200-1]
645968028
FgonA2_010100000210
hypothetical
prote in
[Fusobacterium
gonidiaformans
ATCC 25563]
651311721
HMPREF0240_00666
ABC
transporter,
permease/ATP-binding
prote in
[Clostridium sp.
D5]
645961332
F3_010100004750
hypothetical
prote in
[Fusobacterium
sp. 3_1_5R]
648564064
HMPREF9530_01507
conserved
hypothetical
prote in
[Escherichia coli
MS 21-1]
650078473
HMPREF9474_02524
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
646223246
BSCG_01784
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
643117815
CLOHIR_01027
branched-chain
amino acid
uptake carrier
[Clostridium
hiranonis
TO-931 DSM
13275]
644326810
HMPREF0530_0654
conserved
hypothetical
prote in
[Lactobacillus
paracasei ATCC
25302]
651384582
HMPREF9477_01824
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
648906397
HMPREF9010_02779
putative
fasciclin domain
prote in
[Bacteroides sp.
3_1_23]
646282449
FVAG_02876
conserved
hypothetical
prote in
[Fusobacterium
varium ATCC
27725]
650539055
CCU_06860
SpoIVB
peptidase S55.
[Coprococcus
sp. ART55/1]
650273290
HMPREF9406_3575
hypothetical
prote in
[Clostridium sp.
HGF2]
651514044
HMPREF9412_4420
urea ABC
transporter,
permease
protein UrtC
[Paenibacillus
sp. HGF5]
644158986
HOLDEFILI_00729
Bacterial Ig-like
domain (group
2). [Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
644288721
HMPREF0497_1839
conserved
hypothetical
prote in
[Lactobacillus
buchneri ATCC
11577]
650557758
FPR_04000
Competence-damaged
prote in .
[Faecalibacterium
prausnitzii
SL3/3]
650583155
RTO_10200
aspartyl/glutamyl-tRNA(Asn/Gln)
amidotransferase
subunit A
[Ruminococcus
torques L2-14]
644326872
HMPREF0530_0716
conserved
hypothetical
prote in
[Lactobacillus
paracasei ATCC
25302]
644285718
HMPREF0496_1938
conserved
hypothetical
prote in
[Lactobacillus
brevis
gravesensis
ATCC 27305]
646275368
BSIG_02200
sugar
phosphate
isomerase/epimerase
[Bacteroides sp.
1_1_6]
648892965
HMPREF0106_02506
conserved
hypothetical
prote in
[Bacteroides sp.
D22]
650083941
HMPREF9475_03230
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
650551013
ERE_23450
Transcriptional
regulator
containing an
amidase domain
and an
AraC-type
DNA-bind ing
HTH domain
[Eubacterium
recta le M104/1]
650546225
EUR_02670
Transcriptional
regulator
containing an
amidase domain
and an
AraC-type
DNA-bind ing
HTH domain
[Eubacterium
rectale DSM
17629]
650565954
ROI_17180
uracil-xanth ine
permease
[Roseburia
intestinalis
M 50/1]
643922687
HcinC1_010100006295
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
651351813
HMPREF0987_01318
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
647937719
HMPREF0485_00600
copper
resistance
protein D
[Klebsiella sp.
1_1_55]
650546270
EUR_03130
ATP-dependent
metalloprotease
FtsH
[Eubacterium
rectale DSM
17629]
647449914
CUW_0001
putative
membrane
prote in
[Turicibacter
sanguinis
PC909]
651516201
HMPREF9412_5992
putative ATP
synthase F0, A
subunit
[Paenibacillus
sp. HGF5]
650083273
HMPREF9475_02563
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
646241256
MBAG_01093
conserved
hypothetical
prote in
[Coprobacillus
sp. D7]
643927671
Lparp8_010100008355
hypothetical
prote in
[Lactobacillus
paracasei
8700:2]
650557314
FP2_31380
Gluconolactonase
[Faecalibacterium
prausnitzii
L2-6]
650350748
HMPREF9443_00528
conserved
domain prote in
[Phascolarctobacterium
sp. YIT 12067]
651546300
HMPREF9538_00061
ABC
transporter,
substrate-b ind ing
protein, family
5 [Klebsiella sp.
MS 92-3]
643922183
HcinC1_010100003620
deth iob iotin
synthetase
[Helicobacter
cinaedi CCUG
18818]
644208916
CLOSTMETH_02873
ATPases with
chaperone
activity,
ATP-bind ing
subunit
[Clostridium
methylpentosum
R2, DSM 5476]
650555477
FP2_10410
Predicted
phosphohydrolases
[Faecalibacterium
prausnitzii
L2-6]
645966872
FulcA4_010100011126
hypothetical
prote in
[Fusobacterium
ulcerans ATCC
49185]
643138297
DESPIG_01079
Predicted
permeases
[Desulfovibrio
piger ATCC
29098]
643115076
CLONEX_02585
Signal
transduction
histidine kinase
[Clostridium
nexile DSM
1787]
646240924
MBAG_00761
MATE efflux
family protein
[Coprobacillus
sp. D7]
651552214
HMPREF9538_05978
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
651335509
HMPREF0991_01675
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650579963
CK5_10860
hypothetical
prote in
[Ruminococcus
obeum A2-162]
644166250
BACCELL_01413
Beta-glucosidase-related
glycosidases
[Bacteroides
cellulosilyticus
DSM 14838]
648884299
HMPREF9007_03137
ABC transporter
permease
[Bacteroides sp.
1_1_14]
650542098
ENC_17620
Uncharacterized
conserved
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
646259609
OFAG_01565
conserved
hypothetical
prote in
[Oxalobacter
formigenes
HOxBLS]
644293751
HMPREF0348_0576
cardiolipin
synthetase
[Enterococcus
faecalis
TX0104]
651549468
HMPREF9538_03230
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
650076779
HMPREF9474_00843
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
644346263
HMPREF0175_0934
conserved
hypothetical
prote in
[Bifidobacterium
longum longum
ATCC 55813]
650082470
HMPREF9475_01774
superoxide
reductase
[Clostridium
symbiosum
WAL-14673] 648690841
HMPREF9521_02689
putative
cardiolipin
synthase
[Enterococcus
faecalis
TX2134]
650080568
HMPREF9474_04577
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
647938433
HMPREF0485_01309
hypothetical
prote in
[Klebsiella sp.
1_1_55]
646278009
BSIG_04821
ABC transporter
permease
[Bacteroides sp.
1_1_6]
648907716
HMPREF9008_03651
hypothetical
prote in
[Bacteroides sp.
20_3]
646303417
HMPREF0026_00899
cytochrome d
ubiqu ino l
oxidase,
subunit II
[Acinetobacter
junii SH205]
645274251
Bfra3_010100001693
putative
lipoprote in
[Bacteroides
fragilis 3_1_12]
647784138
HMPREF5045_01579
protein tyrosine
phosphatase
[Lactobacillus
crispatus
125-2-CHN]
650043321
HMPREF1016_02896
hypothetical
prote in
[Bacteroides
eggerthii
1_2_48FAA]
650561289
GPA_18000
Formate-dependent
n itrite
reductase,
membrane
component
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
644143867
BACCOPRO_00196
cell division
protein FtsX
[Bacteroides
coprophilus
DSM 18228]
651540721
HMPREF9445_01797
hypothetical
prote in
[Bacteroides
clarus YIT
12056]
644319375
HMPREF0548_1758
protein tyrosine
phosphatase
[Lactobacillus
ultunensis DSM
16047]
646110639
HMPREF0518_0666
conserved
hypothetical
prote in
[Lactobacillus
helveticus DSM
20075]
651516797
HMPREF9412_0784
cadmium,
cobalt and
zinc/H( )-K( )
antiporter
[Paenibacillus
sp. HGF5]
644156045
RUMHYD_01718
ATPase, P-type
(transporting),
HAD
superfamily,
subfamily IC
[Blautia
hydrogenotrophica
DSM 10507]
651314405
HMPREF0240_03368
putative
transcriptional
regulator, AraC
family with
Parallel
beta-helix
repeat
[Clostridium sp.
D5]
644177904
CLOSTASPAR_02519
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Clostridium
asparagiforme
DSM 15981]
644269238
ROSEINA2194_00735
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
647941746
HMPREF0485_04583
drug:H
antipor ter -1
(DHA2) family
drug resistance
MFS transporter
[Klebsiella sp.
1_1_55]
646035400
ChatD1_010100005286
hypothetical
prote in
[Clostridium
hathewayi DSM
13479]
643925354
HpulM9_010100007336
thioesterase
family protein
[Helicobacter
pullorum MIT
98-5489]
644355615
HMPREF0352_2653
possible
transcription
regulation
prote in
[Enterococcus
faecium
TX1330]
651545501
HMPREF9446_03247
peptidase M16
inactive domain
prote in
[Bacteroides
fluxus YIT
12057]
651571513
HMPREF9413_5263
glycosyltransferase,
group 2 family
prote in
[Paenibacillus
sp. HGF7]
648925577
HMPREF0326_00313
tricarboxylate
transporter
family protein
[Desulfovibrio
sp. 3_1_syn3]
644166741
BACCELL_01904
Signal
transduction
histidine kinase
[Bacteroides
cellulosilyticus
DSM 14838]
644166785
BACCELL_01948
Uncharacterized
protein related
to the
periplasmic
component o f
the Tol
b iopolymer
transport
system
[Bacteroides
cellulosilyticus
DSM 14838]
651346374
HMPREF0993_01961
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
648527839
HMPREF9536_02283
hypothetical
prote in
[Escherichia coli
MS 84-1]
650538903
CCU_04910
Colicin V
production
prote in .
[Coprococcus
sp. ART55/1]
651516561
HMPREF9412_5906
integral
membrane
protein, YkoY
family
[Paenibacillus
sp. HGF5]
646039383
ChatD1_010100025396
b ind ing-prote in-dependent
transport
systems inner
membrane
component
[Clostridium
hathewayi DSM
13479]
646896646
LRHM_0935
multidrug ABC
transporter
permease
component
[Lactobacillus
rhamnosus GG,
ATCC 53103]
650088580
HMPREF9464_01747
hypothetical
prote in
[Sutterella
wadsworthensis
3_1_45B]
648925442
HMPREF0326_00178
cobalamin
biosynthesis
protein CobD
[Desulfovibrio
sp. 3_1_syn3]
650188693
HMPREF9436_02431
K -dependent
Na /Ca
exchanger-like
prote in
[Faecalibacterium
cf. prausnitzii
KLE1255]
643098877
BACEGG_03646
Beta-1,4-xylanase
[Bacteroides
eggerthii DSM
20697]
650559170
FPR_19820
Uncharacterized
prote in
conserved in
bacteria
[Faecalibacterium
prausnitzii
SL3/3]
647449441
CUW_2001
transporter,
anaerobic
C4-dicarboxylate
uptake C (DcuC)
family protein
[Turicibacter
sanguinis
PC909]
650544312
ENC_45500 PTS
system IID
component,
Man family (TC
4.A.6)
[Enterobacter
cloacae cloacae
NCTC 9394]
646303900
HMPREF0026_01375
serine/threonine
protein kinase
[Acinetobacter
junii SH205]
650521502
AL1_11560
hypothetical
prote in
[Alistipes shahii
WAL 8301]
643147686
PROVALCAL_03373
NADH
dehydrogenase
subunit M (EC
1.6.5.3)
[Providencia
alcalifaciens
DSM 30120]
647941147
HMPREF0485_03991
conserved
hypothetical
prote in
[Klebsiella sp.
1_1_55] 643927222
Lparp8_010100006088
1-phosphofructokinase
[Lactobacillus
paracasei
8700:2]
647491523
HMPREF0281_02417
conserved
hypothetical
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
648689544
HMPREF9521_01391
conserved
domain prote in
[Enterococcus
faecalis
TX2134]
650561307
GPA_18340
ABC-type
n itra te/su lfonate/b icarbonate
transport
system,
permease
component
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378] 647370976
EDWATA_03709
thiosulfate
reductase
cytochrome B
subunit
[Edwardsiella
tarda ATCC
23685]
650023239
HMPREF1004_04694
type-IV
secretion
system protein
TraC [Ralstonia
sp. 5_7_47FAA]
651558046
HMPREF9442_02784
Sodium:neurotransmitter
symporter
family protein
[Paraprevotella
xylaniphila YIT
11841]
644144178
BACCOPRO_00507
Outer
membrane
prote in
[Bacteroides
coprophilus
DSM 18228]
646259860
OFAG_01814
predicted
prote in
[Oxalobacter
formigenes
HOxBLS]
647370556
EDWATA_03289
cytochrome
c- type
biogenesis
protein CcmF
[Edwardsiella
tarda ATCC
23685]
651344880
HMPREF0993_00512
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
647437107
CUU_3814
hypothetical
prote in
[Bacteroides
vulgatus PC510]
646037232
ChatD1_010100014526
Type IV
secretory
pathway VirB4
components-like
prote in
[Clostridium
hathewayi DSM
13479]
650197303
HMPREF0623_0041
possible xylan
esterase
[Pediococcus
acidilactici DSM
20284] 644393637
HMPREF0539_2989
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
650522450
AL1_23340
Domain of
unknown
function
(DUF303).
[Alistipes shahii
WAL 8301]
650533518
CLS_14030
prote in
translocase
subunit
secF/protein
translocase
subunit secD
[Clostridium cf.
saccharolyticum
K10]
650047005
HMPREF1023_02647
VanW like
prote in
[Eggerthella sp.
1_3_56FAA]
644096976
PROPEN_01684
Arabinose efflux
permease
[Proteus penneri
ATCC 35198]
650188140
HMPREF9436_01878
periplasmic
b ind ing prote in
[Faecalibacterium
cf. prausnitzii
KLE1255]
643124257
ANHYDRO_00130
Signal
transduction
histidine kinase
[Anaerococcus
hydrogenalis
DSM 7454]
650520823
AL1_03040
Protein of
unknown
function
(DUF1469).
[Alistipes shahii
WAL 8301]
644326778
HMPREF0530_0622
transposase
[Lactobacillus
paracasei ATCC
25302]
651352883
HMPREF0987_02365
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
650542559
ENC_23760
diguanylate
cyclase (GGDEF)
domain
[Enterobacter
cloacae cloacae
NCTC 9394]
646260623
OFBG_00435
major Facilitator
Superfamily
prote in
[Oxalobacter
formigenes
OXCC13]
650570361
RO1_27120
Predicted
membrane
protein involved
in D-alanine
export
[Roseburia
intestinalis
XB6B4]
650544764
EC1_03750
CDP-diglyceride
synthetase
[Eubacterium
cylindroides
T2-87]
650003019
HMPREF9011_01542
hypothetical
prote in
[Bacteroides sp.
3_1_40A]
643116434
CLONEX_03943
ABC-type
multidrug
transport
system, ATPase
and permease
components
[Clostridium
nexile DSM
1787]
650014539
HMPREF0983_03196
putative sensory
transducer
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
643923429
HcinC1_010100010041
hypothetical
prote in
[Helicobacter
cinaedi CCUG
18818]
644161423
HOLDEFILI_03167
Na -dependent
transporters of
the SNF family
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
646007832
BacD2_010100025854
hypothetical
prote in
[Bacteroides sp.
D2]
650187593
HMPREF9436_01330
PASTA domain
prote in
[Faecalibacterium
cf. prausnitzii
KLE1255]
648924593
HMPREF0189_02295
Na /H
antiporter
family protein
[Burkholderiales
bacterium
1_1_47]
647939199
HMPREF0485_02072
peptide/n icke l
transport
system
permease
[Klebsiella sp.
1_1_55]
651546302
HMPREF9538_00063
putative
D,D-d ipeptide
transport
system
permease
protein DdpC
[Klebsiella sp.
MS 92-3]
650567784
ROI_38610
Predicted
membrane
protein involved
in D-alanine
export
[Roseburia
intestinalis
M 50/1]
644392194
HMPREF0539_1561
ABC superfamily
ATP binding
cassette
transporter ABC
prote in
[Lactobacillus
rhamnosus
LMS2-1]
646897162
LRHM_1448
putative
multidrug ABC
transporter
ATP-bind ing
and permease
components
[Lactobacillus
rhamnosus GG,
ATCC 53103]
647782851
HMPREF5045_00304
branched-chain
amino acid
transport
system II carrier
prote in
[Lactobacillus
crispatus
125-2-CHN]
651554072
HMPREF9439_01619
Na /H
antiporter
family protein
[Parasutterella
excrementihominis
YIT 11859]
647370970
EDWATA_03703
intracellular
growth
attenuator
protein IgaA
[Edwardsiella
tarda ATCC
23685]
650542976
ENC_28940
hypothetical
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
644154414
RUMHYD_00087
hypothetical
protein [Blautia
hydrogenotrophica
DSM 10507]
646239619
CSBG_02941
polyA
polymerase
[Clostridium sp.
7_2_43FAA]
648926006
HMPREF0326_00736
sun protein
[Desulfovibrio
sp. 3_1_syn3]
643156491
PRABACTJOHN_02120
Uncharacterized
conserved
prote in
[Parabacteroides
johnsonii DSM
18315]
648925549
HMPREF0326_00285
RIP
metalloprotease
RseP
[Desulfovibrio
sp. 3_1_syn3]
650320148
HMPREF9420_1354
a lpha-1,2-mannosidase
[Prevotella
salivae DSM
15606]
650012057
HMPREF0983_00548
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
651678289
HMPREF9418_0845
monovalent
cation:proton
antipor ter -2
family
transporter
[Neisseria
macacae ATCC
33926]
643927681
Lparp8_010100008405
taurine
transport
system
permease
protein tauC
[Lactobacillus
paracasei
8700:2]
647449692
CUW_2143
tetratricopeptide
repeat protein
[Turicibacter
sanguinis
PC909]
647941425
HMPREF0485_04265
general
secretion
pathway protein
F [Klebsiella sp.
1_1_55]
644326372
HMPREF0530_0219
1-phosphofructokinase
[Lactobacillus
paracasei ATCC
25302]
650076976
HMPREF9474_01040
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
651571493
HMPREF9413_5243
putative ATP
synthase F0, A
subunit
[Paenibacillus
sp. HGF7]
651337213
HMPREF0991_03342
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
648881601
HMPREF9007_00293
regulatory
protein SusR
[Bacteroides sp.
1_1_14]
647490731
HMPREF0281_01625
putative
membrane
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
647899077
HMPREF0969_02978
phosphate ABC
transporter
[Bacteroides sp.
D20] 650062836
HMPREF0864_03394
L-seryl-tRNA
selenium
transferase
[Enterobacteriaceae
bacterium
9_2_54FAA]
650534888
CLS_31100 Na
-dependent
transporters of
the SNF family
[Clostridium cf.
saccharolyticum
K10]
644293876
HMPREF0348_0701
cell wall surface
anchor family
prote in
[Enterococcus
faecalis
TX0104]
645961708
F3_010100006629
heavy
meta l-transporting
ATPase
[Fusobacterium
sp. 3_1_5R]
650270920
HMPREF9406_0672
Sodium:neurotransmitter
symporter
family protein
[Clostridium sp.
HGF2] 650081705
HMPREF9475_01010
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
646277633
BSIG_04449
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
647370679
EDWATA_03412
L-seryl-tRNA
selenium
transferase
[Edwardsiella
tarda ATCC
23685] 651544877
HMPREF9446_02623
hypothetical
prote in
[Bacteroides
fluxus YIT
12057]
650085865
HMPREF9459_00906
GNAT family
acetyltransferase
[Streptococcus
anginosus
1_2_62CV]
643096993
BACEGG_01762
ABC-type
transport
system,
involved in
lipoprote in
release,
permease
component
[Bacteroides
eggerthii DSM
20697]
651551224
HMPREF9538_04987
undecaprenyl-phosphate
alpha-N-acetylglucosaminyl
1-phosphatetransferase
[Klebsiella sp.
MS 92-3]
647939573
HMPREF0485_02432
hypothetical
prote in
[Klebsiella sp.
1_1_55]
646273200
BSIG_00060
peptidase
[Bacteroides sp.
1_1_6]
648690047
HMPREF9521_01895
cell wall surface
anchor family
prote in
[Enterococcus
faecalis
TX2134]
651551792
HMPREF9538_05555
hypothetical
prote in
[Klebsiella sp.
MS 92-3]
651344728
HMPREF0993_00360
hypothetical
prote in
[Lachnospiraceae
bacterium
5_1_57FAA]
647942117
HMPREF0485_04950
undecaprenyl-phosphate
alpha-N-acetylglucosaminyl
1-phosphatetransferase
[Klebsiella sp.
1_1_55] 650019204
HMPREF1004_00658
branched-chain
amino acid ABC
transporter,
periplasmic
amino
acid-b ind ing
prote in
[Ralstonia sp.
5_7_47FAA]
646234738
BSFG_02727
predicted
prote in
[Bacteroides sp.
4_3_47FAA]
644159996
HOLDEFILI_01740
hypothetical
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650003492
HMPREF9011_02015
hypothetical
prote in
[Bacteroides sp.
3_1_40A]
651337630
HMPREF0994_00216
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
644358212
HMPREF0492_0511
protein tyrosine
phosphatase
[Lactobacillus
acidophilus
ATCC 4796]
651331793
HMPREF0988_01208
hypothetical
prote in
[Lachnospiraceae
bacterium
1_4_56FAA]
644160891
HOLDEFILI_02635
hypothetical
prote in
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650010369
HMPREF1007_02573
phosphate
b ind ing prote in
[Bacteroides sp.
4_1_36]
651344266
HMPREF0994_06797
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
651544199
HMPREF9446_01945
hypothetical
prote in
[Bacteroides
fluxus YIT
12057]
643927254
Lparp8_010100006250
subtilisin-like
serine protease
[Lactobacillus
paracasei
8700:2] 650273309
HMPREF9406_3594
putative
membrane
prote in
[Clostridium sp.
HGF2]
646259351
OFAG_01314
major facilitator
transporter
[Oxalobacter
formigenes
HOxBLS]
648881978
HMPREF9007_00685
sugar
phosphate
isomerase/epimerase
[Bacteroides sp.
1_1_14]
650558421
FPR_11360
Permeases of
the
drug/metabolite
transporter
(DMT)
superfamily
[Faecalibacterium
prausnitzii
SL3/3]
647370821
EDWATA_03554
ECA
biosynthesis
protein WzyE
[Edwardsiella
tarda ATCC
23685]
646259662
OFAG_01618
FtsL cell division
prote in
[Oxalobacter
formigenes
HOxBLS]
647938121
HMPREF0485_00997
inner membrane
transporter
YdhC [Klebsiella
sp. 1_1_55]
651546370
HMPREF9538_00131
oxaloacetate
decarboxylase
beta chain
[Klebsiella sp.
MS 92-3]
650553532
EUS_15730 ATP
synthase
subunit C.
[Eubacterium
siraeum 70/3]
647939460
HMPREF0485_02319
hypothetical
prote in
[Klebsiella sp.
1_1_55]
648885772
HMPREF9007_04662
5-nucleotidase
[Bacteroides sp.
1_1_14]
646278032
BSIG_04844
5'-nucleotidase
[Bacteroides sp.
1_1_6]
650045849
HMPREF1023_01512
DUF218
domain-conta in ing
prote in
[Eggerthella sp.
1_3_56FAA]
651552163
HMPREF9538_05927
drug resistance
transporter,
Bcr/CflA
subfamily
[Klebsiella sp.
MS 92-3]
643139456
DESPIG_02239
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
650571311
RO1_38640
uracil-xanth ine
permease
[Roseburia
intestinalis
XB6B4]
650574266
RUM_07790
tRNA(Ile)-lysidine
synthetase,
N-terminal
domain/tRNA(Ile)-lysidine
synthetase,
C-terminal
domain
[Ruminococcus
sp. 18P13]
650319420
HMPREF9420_0641
BexD/CtrA/VexA
family
polysaccharide
export prote in
[Prevotella
salivae DSM
15606]
650550966
ERE_22950
ATP-dependent
metalloprotease
FtsH
[Eubacterium
recta le M104/1]
644390884
HMPREF0539_0260
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus
LMS2-1]
650189149
HMPREF9436_02887
transporter,
auxin efflux
carrier family
prote in
[Faecalibacterium
cf. prausnitzii
KLE1255]
647446650
CUO_0333
conserved
domain prote in
[Enterococcus
faecalis PC4.1]
644182612
CATMIT_00348
Carbon
starvation
prote in ,
predicted
membrane
prote in
[Catenibacterium
mitsuokai DSM
15897]
644208104
CLOSTMETH_02059
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
647938374
HMPREF0485_01250
urea
carboxylase-associated
prote in 2
[Klebsiella sp.
1_1_55]
651514721
HMPREF9412_6624
hypothetical
prote in
[Paenibacillus
sp. HGF5]
650321164
HMPREF9420_2355
hypothetical
prote in
[Prevotella
salivae DSM
15606]
643915667
Cbac1_010100010730
putative Na(
)/H( ) antiporter
[Clostridiales
sp. 1_7_47FAA]
650578714
CK1_36100
Signal
transduction
histidine kinase
[Ruminococcus
sp. SR1/5]
646304719
HMPREF0026_02170
urea ABC
transporter,
permease UrtC
[Acinetobacter
junii SH205] 651541603
HMPREF9445_02679
glycosyl
hydrolase,
family 88
[Bacteroides
clarus YIT
12056]
650022163
HMPREF1004_03627
cytochrome c
oxidase
accessory
protein CcoG
[Ralstonia sp.
5_7_47FAA]
645965675
FulcA4_010100005140
ABC
transporter,
permease
prote in ,
putative
[Fusobacterium
ulcerans ATCC
49185]
645960293
BcroD2_010100012253
hypothetical
prote in
[Butyrivibrio
crossotus DSM
2876]
650019780
HMPREF1004_01238
n itrogen
regulatory
protein P-II 2
[Ralstonia sp.
5_7_47FAA]
648544462
HMPREF9543_02515
YhhN-like
prote in
[Escherichia coli
MS 146-1]
648573934
HMPREF9541_00414
YhhN-like
prote in
[Escherichia coli
MS 116-1] 648586996
HMPREF9553_03220
YhhN-like
prote in
[Escherichia coli
MS 200-1]
648599168
HMPREF9549_04237
YhhN-like
prote in
[Escherichia coli
MS 185-1]
648522805
HMPREF9552_02973
YhhN-like
prote in
[Escherichia coli
MS 198-1]
645347742
ShiD9_010100018005
conserved inner
membrane
protein [Shigella
sp. D9]
648530874
HMPREF9536_05321
YhhN-like
prote in
[Escherichia coli
MS 84-1] 648564039
HMPREF9530_01482
YhhN-like
prote in
[Escherichia coli
MS 21-1]
646110916
HMPREF0518_0939
conserved
hypothetical
prote in
[Lactobacillus
helveticus DSM
20075]
644358248
HMPREF0492_0547
phosphoglycerol
transferase/alkaline
phosphatase
superfamily
prote in
[Lactobacillus
acidophilus
ATCC 4796]
644319328
HMPREF0548_1711
phosphoglycerol
transferase/alkaline
phosphatase
superfamily
prote in
[Lactobacillus
ultunensis DSM
16047]
651328088
HMPREF0990_00325
precorrin-2
C20-methyltransferase
[Lachnospiraceae
bacterium
1_1_57FAA]
650047391
HMPREF1026_00089
precorrin-2
C(20)-methyltransferase
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651364566
HMPREF1018_03408
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
646269098
BSHG_00522
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
647883085
HMPREF0101_00176
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
651362270
HMPREF1018_01140
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
646272142
BSHG_03524
exported
prote in
[Bacteroides sp.
3_2_5]
647886379
HMPREF0101_03424
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
645274382
Bfra3_010100002348
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
647489394
HMPREF0281_00287
putative
membrane
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
646271468
BSHG_02857
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5] 647438234
CUU_0085
efflux ABC
transporter,
permease
prote in
[Bacteroides
vulgatus PC510]
646230960
BSEG_03432 cell
division protein
FtsX
[Bacteroides
dore i
5_1_36/D4]
647889548
HMPREF0105_1939
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_33FAA]
646215285
BSBG_03567
cell division
protein FtsX
[Bacteroides sp.
9_1_42FAA] 650001812
HMPREF9011_00364
cell division
protein FtsX
[Bacteroides sp.
3_1_40A]
643121090
BACDOR_01999
cell division
protein FtsX
[Bacteroides
dorei DSM
17855]
644098035
PROPEN_02745
HlyD family
secretion
prote in .
[Proteus penneri
ATCC 35198]
644347006
HMPREF0175_1665
conserved
hypothetical
prote in
[Bifidobacterium
longum longum
ATCC 55813]
645276801
Bfra3_010100014464
putative
lipoprote in
[Bacteroides
fragilis 3_1_12]
650528479
BIL_09630
hypothetical
prote in
[Bifidobacterium
longum longum
F8]
648599465
HMPREF9549_04535
type I secretion
membrane
fusion protein,
HlyD family
[Escherichia coli
MS 185-1]
651365636
HMPREF1018_04460
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647886344
HMPREF0101_03390
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
643913068
BloniC5_010100008604
hypothetical
prote in
[Bifidobacterium
longum longum
CCUG 52486] 646270239
BSHG_01650
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
650055257
HMPREF0177_01646
hypothetical
prote in
[Bifidobacterium
sp.
12_1_47BFAA]
648553093
HMPREF9534_00730
YhhN-like
prote in
[Escherichia coli
MS 69-1]
648561195
HMPREF9550_03244
YhhN-like
prote in
[Escherichia coli
MS 187-1]
648590550
HMPREF9551_01328
YhhN-like
prote in
[Escherichia coli
MS 196-1]
646210757
ESAG_04450
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
648541348
HMPREF9548_04834
YhhN-like
prote in
[Escherichia coli
MS 182-1] 648550230
HMPREF9531_03214
YhhN-like
prote in
[Escherichia coli
MS 45-1]
648532426
HMPREF9540_01043
YhhN-like
prote in
[Escherichia coli
MS 115-1]
645352808
E4_010100020721
conserved inner
membrane
prote in
[Escherichia sp.
4_1_40B]
648572618
HMPREF9535_04202
YhhN-like
prote in
[Escherichia coli
MS 78-1]
648581405
HMPREF9547_02612
YhhN-like
prote in
[Escherichia coli
MS 175-1]
646267909
ESCG_01582
conserved
hypothetical
prote in
[Escherichia sp.
1_1_43]
646226823
BSCG_05317
prismane
prote in
[Bacteroides sp.
2_2_4]
647451529
CUY_0947
hydroxylamine
reductase
[Bacteroides
ovatus SD CMC
3f]
651369104
HMPREF0127_00013
hydroxylamine
reductase
[Bacteroides sp.
1_1_30]
651363439
HMPREF1018_02300
hydroxylamine
reductase
[Bacteroides sp.
2_1_56FAA]
645275636
Bfra3_010100008636
hydroxylamine
reductase
[Bacteroides
fragilis 3_1_12]
647884195
HMPREF0101_01270
hydroxylamine
reductase
[Bacteroides sp.
2_1_16]
646270994
BSHG_02399
prismane
prote in
[Bacteroides sp.
3_2_5]
646274061
BSIG_00908
prismane
prote in
[Bacteroides sp.
1_1_6] 650580713
CK5_19310
hydroxylamine
reductase
[Ruminococcus
obeum A2-162]
647460228
CW1_2906
hydroxylamine
reductase
[Bacteroides
ovatus SD CC
2a]
648892050
HMPREF0106_01573
hydroxylamine
reductase
[Bacteroides sp.
D22]
648883342
HMPREF9007_02133
hydroxylamine
reductase
[Bacteroides sp.
1_1_14] 647879553
HMPREF0102_01433
hydroxylamine
reductase
[Bacteroides sp.
2_1_22]
646007131
BacD2_010100022347
hydroxylamine
reductase
[Bacteroides sp.
D2]
651357033
HMPREF1017_01069
hydroxylamine
reductase
[Bacteroides
ovatus
3_8_47FAA]
647440467
CW3_4816
putative
hydroxylamine
reductase
[Bacteroides
xylanisolvens
SD CC 1b]
646219522
BSAG_02876
prismane
prote in
[Bacteroides sp.
D1]
651365205
HMPREF1018_04036
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
651366475
HMPREF1025_00374
precorrin-2
C20-methyltransferase
[Lachnospiraceae
bacterium
3_1_46FAA] 644327219
HMPREF0530_1059
possible biotin
biosynthesis
prote in
[Lactobacillus
paracasei ATCC
25302]
643928111
Lparp8_010100010575
Putative biotin
synthase
[Lactobacillus
paracasei
8700:2]
644392888
HMPREF0539_2244
possible biotin
synthase
[Lactobacillus
rhamnosus
LMS2-1]
648911629
HMPREF9008_04272
putative
tetratricopeptide
repeat protein
[Bacteroides sp.
20_3]
644176794
CLOSTASPAR_01409
Tryptophan-rich
sensory protein
(mitochondrial
benzodiazepine
receptor
homolog)
[Clostridium
asparagiforme
DSM 15981]
650319846
HMPREF9420_1059
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
646304161
HMPREF0026_01634
conserved
hypothetical
prote in
[Acinetobacter
junii SH205]
646038740
ChatD1_010100022132
Na /H
antiporter
NhaD-like
permease
[Clostridium
hathewayi DSM
13479]
647491796
HMPREF0281_02690
Na /H
antiporter
family protein
[Corynebacterium
ammoniagenes
DSM 20306]
650054180
HMPREF0177_00600
hypothetical
prote in
[Bifidobacterium
sp.
12_1_47BFAA]
647447821
CUW_0891
chloride
transporter, ClC
family
[Turicibacter
sanguinis
PC909]
643115587
CLONEX_03096
CDP-diglyceride
synthetase
[Clostridium
nexile DSM
1787]
647997621
HMPREF0400_00089
rhodanese-related
sulfurtransferase
[Fusobacterium
sp. 1_1_41FAA]
643926778
Lparp8_010100003875
Alpha-galactosidase
[Lactobacillus
paracasei
8700:2]
644354020
HMPREF0352_1070
cardiolipin
synthetase
[Enterococcus
faecium
TX1330]
651513819
HMPREF9412_2468
putative
membrane
prote in
[Paenibacillus
sp. HGF5]
647887047
HMPREF0101_04085
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
644161968
HOLDEFILI_03713
DNA
segregation
ATPase
FtsK/SpoIIIE and
related proteins
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
647447277
CUO_1890
putative
cardiolipin
synthase
[Enterococcus
faecalis PC4.1]
644209452
CLOSTMETH_03409
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
645274352
Bfra3_010100002198
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
650049410
HMPREF1026_02079
hypothetical
prote in
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651356305
HMPREF1017_00349
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
651550831
HMPREF9538_04594
peroxidase-like
prote in
[Klebsiella sp.
MS 92-3]
647450063
CUW_2306
putative
internalin A
[Turicibacter
sanguinis
PC909]
648893490
HMPREF0106_03031
sodium/g lucose
cotransporter 2
[Bacteroides sp.
D22]
644154799
RUMHYD_00472
Na -dependent
transporters of
the SNF family
[Blautia
hydrogenotrophica
DSM 10507] 650022537
HMPREF1004_03994
RND efflux
transporter,
hydrophobe/amphiphile
efflux-1 (HAE1)
family
[Ralstonia sp.
5_7_47FAA]
643124123
BACDOR_05034
hypothetical
prote in
[Bacteroides
dorei DSM
17855]
650521465
AL1_11100
Arabinose efflux
permease
[Alistipes shahii
WAL 8301]
647369253
EDWATA_01984
putative integral
membrane
prote in
[Edwardsiella
tarda ATCC
23685]
643139192
DESPIG_01975
small
GTP-binding
prote in
domain/GTP-bind ing
conserved
hypothetical
prote in
[Desulfovibrio
piger ATCC
29098]
650046182
HMPREF1023_01841
b ind ing-prote in-dependent
transport
system inner
membrane
component
[Eggerthella sp.
1_3_56FAA]
650351852
HMPREF9443_01632
hypothetical
prote in
[Phascolarctobacterium
sp. YIT 12067]
646251817
FSAG_00798
pyridine
nucleotide-d isu lph ide
oxidoreductase
[Fusobacterium
sp. 2_1_31]
648543230
HMPREF9543_01283
SPFH domain /
Band 7 family
prote in
[Escherichia coli
MS 146-1]
650561330
GPA_18790
hypothetical
prote in
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
650047243
HMPREF1023_02880
hypothetical
prote in
[Eggerthella sp.
1_3_56FAA]
650321440
HMPREF9420_2628
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
647783966
HMPREF5045_01409
glycosyltransferase
[Lactobacillus
crispatus
125-2-CHN]
651315319
HMPREF0240_04280
hypothetical
prote in
[Clostridium sp.
D5]
643912528
BloniC5_010100005960
hypothetical
prote in
[Bifidobacterium
longum longum
CCUG 52486]
651347915
HMPREF0992_00118
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
646265946
HWAG_01310
conserved
hypothetical
prote in
[Helicobacter
winghamensis
ATCC BAA-430]
651342429
HMPREF0994_04977
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650521072
AL1_06190
hypothetical
prote in
[Alistipes shahii
WAL 8301]
650520900
AL1_04050
NADH:ubiquinone
oxidoreductase,
Na(
)-translocating,
C subunit
[Alistipes shahii
WAL 8301]
646898340
LRHM_2599
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
644429756
HMPREF0555_1823
ABC superfamily
ATP binding
cassette
transporter
permease
[Leuconostoc
mesenteroides
cremoris ATCC
19254]
644268748
ROSEINA2194_00244
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Roseburia
inulinivorans
DSM 16841]
647367760
EDWATA_00491
hypothetical
prote in
[Edwardsiella
tarda ATCC
23685]
648533405
HMPREF9540_02022
transporter,
major facilitator
family protein
[Escherichia coli
MS 115-1]
648589004
HMPREF9553_05229
transporter,
major facilitator
family protein
[Escherichia coli
MS 200-1]
648563955
HMPREF9530_01398
transporter,
major facilitator
family protein
[Escherichia coli
MS 21-1]
645350963
E4_010100011478
MFS transport
protein AraJ
[Escherichia sp.
4_1_40B]
648524330
HMPREF9552_04499
transporter,
major facilitator
family protein
[Escherichia coli
MS 198-1]
646207060
ESAG_00793
AraJ MFS
transporter
[Escherichia sp.
3_2_53FAA] 648582470
HMPREF9547_03678
conserved
domain prote in
[Escherichia coli
MS 175-1]
648538792
HMPREF9548_02277
transporter,
major facilitator
family protein
[Escherichia coli
MS 182-1]
648573454
HMPREF9535_05039
conserved
domain prote in
[Escherichia coli
MS 78-1]
645347281
ShiD9_010100015705
MFS transport
protein AraJ
[Shigella sp. D9]
648550869
HMPREF9531_03854
transporter,
major facilitator
family protein
[Escherichia coli
MS 45-1]
648545792
HMPREF9543_03845
transporter,
major facilitator
family protein
[Escherichia coli
MS 146-1]
648560553
HMPREF9550_02600
transporter,
major facilitator
family protein
[Escherichia coli
MS 187-1]
648575036
HMPREF9541_01517
transporter,
major facilitator
family protein
[Escherichia coli
MS 116-1] 648598508
HMPREF9549_03577
transporter,
major facilitator
family protein
[Escherichia coli
MS 185-1]
648592031
HMPREF9551_02810
conserved
domain prote in
[Escherichia coli
MS 196-1]
644180528
CLOSTASPAR_05145
ABC-type sugar
transport
system,
permease
component
[Clostridium
asparagiforme
DSM 15981]
648527034
HMPREF9536_01477
transporter,
major facilitator
family protein
[Escherichia coli
MS 84-1]
648549393
HMPREF9531_02376
type I secretion
membrane
fusion protein,
HlyD family
[Escherichia coli
MS 45-1]
648690994
HMPREF9521_02842
ABC
transporter,
permease
prote in
[Enterococcus
faecalis
TX2134]
648584278
HMPREF9553_00501
type I secretion
membrane
fusion protein,
HlyD family
[Escherichia coli
MS 200-1]
646257468
FSDG_01881
polysaccharide
biosynthesis
prote in
[Fusobacterium
sp. 7_1]
646895845
LRHM_0174
taurine ABC
transporter
permease
component
[Lactobacillus
rhamnosus GG,
ATCC 53103]
645279647
B2_010100004428
hypothetical
prote in
[Bacteroides sp.
2_1_7]
651569249
HMPREF9413_4285
putative
membrane
prote in
[Paenibacillus
sp. HGF7]
646227247
BSCG_05733
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
648690988
HMPREF9521_02836
hypothetical
prote in
[Enterococcus
faecalis
TX2134]
646285558
HMPREF0619_00126
conserved
hypothetical
prote in
[Parabacteroides
sp. D13] 648907095
HMPREF9010_04846
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_23]
644293262
HMPREF0348_0099
lipoprote in
[Enterococcus
faecalis
TX0104]
648552821
HMPREF9534_00458
type I secretion
membrane
fusion protein,
HlyD family
[Escherichia coli
MS 69-1]
645275902
Bfra3_010100009957
decarboxylating
precorrin-6y
C5,15-methyltransferase
[Bacteroides
fragilis 3_1_12]
647884587
HMPREF0101_01653
decarboxylating
precorrin-6y
C5,15-methyltransferase
[Bacteroides sp.
2_1_16]
646271287
BSHG_02683
decarboxylating
precorrin-6y
C5,15-methyltransferase
[Bacteroides sp.
3_2_5]
651363771
HMPREF1018_02623
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
650010102
HMPREF1007_02308
NodT family
e fflux
transporter
[Bacteroides sp.
4_1_36]
644154523
RUMHYD_00196
precorrin-2
C20-methyltransferase
(EC
2.1.1.130)/cobalt-factor
II
C20-methyltransferase
(EC 2.1.1.151)
[Blautia
hydrogenotrophica
DSM 10507]
646302802
HMPREF0026_00295
uroporphyrin-III
C-methyltransferase
[Acinetobacter
junii SH205]
646897801
LRHM_2075
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
647899331
HMPREF0969_03230
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
648927664
HMPREF0326_02375
putative
membrane
prote in
[Desulfovibrio
sp. 3_1_syn3]
651513018
HMPREF9412_4924
putative protein
LplC
[Paenibacillus
sp. HGF5]
650013289
HMPREF0983_01850
transporter,
major facilitator
family
[Erysipelotrichaceae
bacterium sp.
3_1_53]
651350923
HMPREF0987_00443
hypothetical
prote in
[Lachnospiraceae
bacterium
9_1_43BFAA]
647938258
HMPREF0485_01134
peroxidase
[Klebsiella sp.
1_1_55]
648829319
HMPREF9399_1439
RND efflux
system,
membrane
fusion protein
CmeA
[Campylobacter
coli JV20]
646003302
BacD2_010100003087
hypothetical
prote in
[Bacteroides sp.
D2]
647899577
HMPREF0969_03471
cobalamin
biosynthesis
protein CobD
[Bacteroides sp.
D20]
650572108
RBR_04600
Predicted
integral
membrane
prote in
[Ruminococcus
bromii L2-63]
645281052
B2_010100011449
hypothetical
prote in
[Bacteroides sp.
2_1_7]
647449396
CUW_1198
aspartate-alanine
antiporter
[Turicibacter
sanguinis
PC909]
644270535
ROSEINA2194_02033
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
643098869
BACEGG_03638
Outer
membrane
receptor
proteins, mostly
Fe transport
[Bacteroides
eggerthii DSM
20697]
648558914
HMPREF9550_00961
site-specific
recombinase,
phage integrase
family
[Escherichia coli
MS 187-1]
650083594
HMPREF9475_02883
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
643100426
BACPEC_01426
hypothetical
prote in
[Bacteroides
pectinophilus
ATCC 43243]
650045822
HMPREF1023_01486
membrane
transporter
[Eggerthella sp.
1_3_56FAA]
644144648
BACCOPRO_00978
hypothetical
prote in
[Bacteroides
coprophilus
DSM 18228]
650319820
HMPREF9420_1033
alpha-glucosidase
[Prevotella
salivae DSM
15606]
646283244
FVAG_01763
serine racemase
[Fusobacterium
varium ATCC
27725]
644271888
ROSEINA2194_03387
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
650061843
HMPREF0864_02415
FecCD
transporter
[Enterobacteriaceae
bacterium
9_2_54FAA]
650076913
HMPREF9474_00977
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
650013918
HMPREF0983_02520
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
644178859
CLOSTASPAR_03474
transcriptional
regulator, AraC
family
[Clostridium
asparagiforme
DSM 15981]
650186757
HMPREF9436_00494
transcriptional
regulator, AraC
family
[Faecalibacterium
cf. prausnitzii
KLE1255]
644287996
HMPREF0497_1140
DMT
superfamily
drug/metabolite
transporter
[Lactobacillus
buchneri ATCC
11577]
644285029
HMPREF0496_1275
DMT
superfamily
drug/metabolite
transporter
[Lactobacillus
brevis
gravesensis
ATCC 27305]
650082637
HMPREF9475_01941
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
643925820
HpulM9_010100009667
multifunctional
tRNA
nucleotidyl
transferase/2'3'-cyclic
phosphodiesterase/2'nucleotidase/phosphatase
[Helicobacter
pullorum MIT
98-5489]
651516733
HMPREF9412_2079
ABC
transporter,
permease
prote in
[Paenibacillus
sp. HGF5]
647436538
CUU_3150
putative
membrane
prote in
[Bacteroides
vulgatus PC510]
643154924
PRABACTJOHN_00553
Signal
transduction
histidine
kinase/Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Parabacteroides
johnsonii DSM
18315]
650026875
HMPREF1011_00323
extracellular
so lu te-b ind ing
prote in
[Anaerostipes
sp. 3_2_56FAA]
644208176
CLOSTMETH_02131
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
648572594
HMPREF9535_04178
conserved
hypothetical
prote in
[Escherichia coli
MS 78-1]
648544440
HMPREF9543_02493
conserved
hypothetical
prote in
[Escherichia coli
MS 146-1]
648541371
HMPREF9548_04857
hypothetical
prote in
[Escherichia coli
MS 182-1]
645347720
ShiD9_010100017895
hypothetical
protein [Shigella
sp. D9]
646267888
ESCG_01561
conserved
hypothetical
prote in
[Escherichia sp.
1_1_43]
650542781
ENC_26380
Protein of
unknown
function
(DUF2756).
[Enterobacter
cloacae cloacae
NCTC 9394]
648590527
HMPREF9551_01305
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
648522829
HMPREF9552_02997
conserved
hypothetical
prote in
[Escherichia coli
MS 198-1]
648530899
HMPREF9536_05346
hypothetical
prote in
[Escherichia coli
MS 84-1]
648561218
HMPREF9550_03267
conserved
hypothetical
prote in
[Escherichia coli
MS 187-1]
646220667
BSAG_04014
N-acetylglucosamine-6-sulfatase
[Bacteroides sp.
D1]
646277128
BSIG_03948
N-acetylglucosamine-6-sulfatase
[Bacteroides sp.
1_1_6]
651359275
HMPREF1017_03285
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
646222577
BSCG_01117
N-acetylglucosamine-6-sulfatase
[Bacteroides sp.
2_2_4]
651371812
HMPREF0127_02692
hypothetical
prote in
[Bacteroides sp.
1_1_30] 647455685
CUY_2828
arylsulfatase
[Bacteroides
ovatus SD CMC
3f]
648906901
HMPREF9010_03285
mucin-desulfa ting
sulfatase
(N-acetylglucosamine-6-sulfatase)
[Bacteroides sp.
3_1_23]
648882254
HMPREF9007_00992
mucin-desulfa ting
sulfatase
(N-acetylglucosamine-6-sulfatase)
[Bacteroides sp.
1_1_14]
644328950
HMPREF0530_2770
alpha-galactosidase
[Lactobacillus
paracasei ATCC
25302]
646897863
LRHM_2137
conserved
hypothetical
prote in
[Lactobacillus
rhamnosus GG,
ATCC 53103]
651366839
HMPREF1025_00735
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
648543529
HMPREF9543_01582
conserved
hypothetical
prote in
[Escherichia coli
MS 146-1]
645350223
E4_010100007794
putative
autoagglutination
prote in
[Escherichia sp.
4_1_40B]
651329852
HMPREF0990_02061
hypothetical
prote in
[Lachnospiraceae
bacterium
1_1_57FAA]
647439972
CW3_3626
arylsulfatase
[Bacteroides
xylanisolvens
SD CC 1b]
647880403
HMPREF0102_02274
N-acetylglucosamine-6-sulfatase
[Bacteroides sp.
2_1_22]
647459935
CW1_3400
conserved
domain prote in
[Bacteroides
ovatus SD CC
2a]
646253921
FSCG_00563
conserved
hypothetical
prote in
[Fusobacterium
sp. 4_1_13]
647785203
HMPREF0946_00518
conserved
hypothetical
prote in
[Fusobacterium
sp. 3_1_36A2]
645353606
PrD11_010100001265
hypothetical
prote in
[Fusobacterium
sp. D11]
651381461
HMPREF0404_00719
hypothetical
prote in
[Fusobacterium
sp. 21_1A]
647825791
HMPREF0406_00786
conserved
hypothetical
prote in
[Fusobacterium
sp. 3_1_33]
650522673
AL1_26140
hypothetical
prote in
[Alistipes shahii
WAL 8301]
646256457
FSDG_00902
conserved
hypothetical
prote in
[Fusobacterium
sp. 7_1]
651353483
HMPREF0401_00227
hypothetical
prote in
[Fusobacterium
sp. 11_3_2]
650008585
HMPREF1007_00819
NSS family
neurotransmitter
Na symporter
[Bacteroides sp.
4_1_36]
643098788
BACEGG_03557
Na -dependent
transporters of
the SNF family
[Bacteroides
eggerthii DSM
20697]
651545553
HMPREF9446_03299
Sodium:neurotransmitter
symporter
family protein
[Bacteroides
fluxus YIT
12057]
647898167
HMPREF0969_02083
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
644145564
BACCOPRO_01894
Na -dependent
transporters of
the SNF family
[Bacteroides
coprophilus
DSM 18228]
646232256
BSFG_00282 cell
division protein
FtsX
[Bacteroides sp.
4_3_47FAA]
647878024
HMPREF0103_3895
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
648908822
HMPREF9008_04365
putative
TonB-dependent
receptor
[Bacteroides sp.
20_3]
646289546
HMPREF0619_04052
conserved
hypothetical
prote in
[Parabacteroides
sp. D13] 648895438
HMPREF0106_04970
mucin-desulfa ting
sulfatase
(N-acetylglucosamine-6-sulfatase)
[Bacteroides sp.
D22]
650080440
HMPREF9474_04457
ABC transporter
sugar permease
[Clostridium
symbiosum
WAL-14163]
650045779
HMPREF1023_01447
hypothetical
prote in
[Eggerthella sp.
1_3_56FAA]
650588308
ENT_23020
ABC-type
transport
system,
involved in
lipoprote in
release,
permease
component
[Enterococcus
sp. 7L76]
650083619
HMPREF9475_02908
hypothetical
prote in
[Clostridium
symbiosum
WAL-14673]
645283106
B2_010100021766
TonB-dependent
receptor,
putative
[Bacteroides sp.
2_1_7]
648890051
HMPREF0104_03882
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_19]
650560075
FPR_29850
hypothetical
prote in
[Faecalibacterium
prausnitzii
SL3/3]
650076643
HMPREF9474_00707
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
647996458
HMPREF0405_00719
conserved
hypothetical
prote in
[Fusobacterium
sp. 3_1_27]
650041114
HMPREF1016_00716
NSS family
neurotransmitter
Na symporter
[Bacteroides
eggerthii
1_2_48FAA]
648577047
HMPREF9541_03529
conserved
hypothetical
prote in
[Escherichia coli
MS 116-1]
648594693
HMPREF9551_05473
conserved
hypothetical
prote in
[Escherichia coli
MS 196-1]
645959478
BcroD2_010100008158
hypothetical
prote in
[Butyrivibrio
crossotus DSM
2876]
646111776
HMPREF0518_1782
conserved
hypothetical
prote in
[Lactobacillus
helveticus DSM
20075]
643910375
BbifN4_010100004619
CDP-diacylg lycero l--g lycero l-3-
phosphate
3-phosphatidyl-transferase
[Bifidobacterium
bifidum NCIMB
41171]
643921167
HcanM9_010100007050
tRNA
nucleotidyl
transferase
[Helicobacter
canadensis MIT
98-5491, ATCC
700968]
645277050
Bfra3_010100015703
hypothetical
prote in
[Bacteroides
fragilis 3_1_12]
644181109
CLOSTASPAR_05727
ABC-type
d ipeptide/o ligopeptide/n icke l
transport
systems,
permease
components
[Clostridium
asparagiforme
DSM 15981]
651557817
HMPREF9442_02555
O-antigen
polymerase
[Paraprevotella
xylaniphila YIT
11841] 650321329
HMPREF9420_2520
conserved
hypothetical
prote in
[Prevotella
salivae DSM
15606]
647856970
HMPREF0847_01507
CAAX amino
terminal
protease family
prote in
[Streptococcus
sp. 2_1_36FAA]
650080416
HMPREF9474_04433
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
644293921
HMPREF0348_0745
ABC superfamily
ATP binding
cassette
transporter,
membrane
prote in
[Enterococcus
faecalis
TX0104]
643927878
Lparp8_010100009410
Na( )/H( )
antiporter
[Lactobacillus
paracasei
8700:2]
648584255
HMPREF9553_00478
hypothetical
prote in
[Escherichia coli
MS 200-1]
648690006
HMPREF9521_01854
efflux ABC
transporter,
permease
prote in
[Enterococcus
faecalis
TX2134]
650015432
HMPREF0983_04194
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
648923123
HMPREF0189_00062
cytochrome D
ubiqu ino l
oxidase,
subunit II
[Burkholderiales
bacterium
1_1_47]
650015430
HMPREF0983_04192
hypothetical
prote in
[Erysipelotrichaceae
bacterium sp.
3_1_53]
651555197
HMPREF9439_02744
cytochrome d
ubiqu ino l
oxidase,
subunit II
[Parasutterella
excrementihominis
YIT 11859]
644327579
HMPREF0530_1410
Na( )/H( )
antiporter
[Lactobacillus
paracasei ATCC
25302]
644165781
BACCELL_00944
hypothetical
prote in
[Bacteroides
cellulosilyticus
DSM 14838]
650562217
GPA_34440
Response
regulator
containing a
CheY-like
receiver domain
and an HTH
DNA-bind ing
domain
[Gordonibacter
pamelaeae
7-10-1-bT ,
DSM 19378]
644101558
COPCOM_01277
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Coprococcus
comes ATCC
27758]
650587298
ENT_09730
Arabinose efflux
permease
[Enterococcus
sp. 7L76]
646229460
BSEG_01948
two-component
system sensor
histidine
kinase/response
regulator
[Bacteroides
dore i
5_1_36/D4]
646304464
HMPREF0026_01923
competence
protein F
[Acinetobacter
junii SH205]
651514649
HMPREF9412_6552
transcriptional
regulatory
protein WalR
[Paenibacillus
sp. HGF5]
651338530
HMPREF0994_01109
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
644227541
EUBHAL_01986
uracil-xanth ine
permease
[Eubacterium
hallii DSM 3353]
643112942
CLONEX_00448
uracil-xanth ine
permease
[Clostridium
nexile DSM
1787]
646222543
BSCG_01083
conserved
hypothetical
prote in
[Bacteroides sp.
2_2_4]
650353364
HMPREF9444_00948
histidine kinase
A domain
prote in
[Succinatimonas
hippei YIT
12066]
645965181
FulcA4_010100002672
exoenzyme
regulatory
protein aepA
precursor
[Fusobacterium
ulcerans ATCC
49185]
650018603
HMPREF1004_00050
cobalt-zinc-cadmium
resistance
protein CzcI
(Cation
effluxsystem
protein czcI)
[Ralstonia sp.
5_7_47FAA]
643121787
BACDOR_02695
Predicted
esterase of the
a lpha-beta
hydrolase
superfamily
[Bacteroides
dorei DSM
17855]
647438519
CUU_3874
phospholipase,
patatin family
[Bacteroides
vulgatus PC510] 647458554
CW1_2101
polysaccharide
biosynthesis
prote in
[Bacteroides
ovatus SD CC
2a]
646207949
ESAG_01672
conserved
hypothetical
prote in
[Escherichia sp.
3_2_53FAA]
646214423
BSBG_02713
conserved
hypothetical
prote in
[Bacteroides sp.
9_1_42FAA]
646229826
BSEG_02311
conserved
hypothetical
prote in
[Bacteroides
dore i
5_1_36/D4]
647890224
HMPREF0105_2599
conserved
hypothetical
prote in
[Bacteroides sp.
3_1_33FAA]
647443342
CW3_2581
polysaccharide
biosynthesis
prote in
[Bacteroides
xylanisolvens
SD CC 1b]
644156549
RUMHYD_02222
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
647491552
HMPREF0281_02446
membrane
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
651348681
HMPREF0992_00872
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
648887860
HMPREF0104_01705
ATP-dependent
DNA helicase
PcrA
[Bacteroides sp.
3_1_19]
648688706
HMPREF9521_00553
transporter,
major facilitator
family protein
[Enterococcus
faecalis
TX2134]
645280412
B2_010100008262
putative
helicase
[Bacteroides sp.
2_1_7]
648910294
HMPREF9008_00800
ATP-dependent
DNA helicase
PcrA
[Bacteroides sp.
20_3]
646303802
HMPREF0026_01281
sodium/b ile
acid symporter
family protein
[Acinetobacter
junii SH205]
646270638
BSHG_02045
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
644294954
HMPREF0348_1756
MFS family
major facilitator
transporter
[Enterococcus
faecalis
TX0104]
651364794
HMPREF1018_03634
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
647885962
HMPREF0101_03012
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16] 651539259
HMPREF9445_00334
ABC
transporter,
ATP-bind ing
prote in
[Bacteroides
clarus YIT
12056]
644100217
PROPEN_04934
apolipoprotein
N-acyltransferase
[Proteus penneri
ATCC 35198]
646241868
MBAG_01684
conserved
hypothetical
prote in
[Coprobacillus
sp. D7]
651340131
HMPREF0994_02704
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1] 651568032
HMPREF9413_0940
acyltransferase
[Paenibacillus
sp. HGF7] 643914239
Cbac1_010100003607
inner-membrane
translocator
[Clostridiales
sp. 1_7_47FAA]
647490700
HMPREF0281_01594
putative
membrane
prote in
[Corynebacterium
ammoniagenes
DSM 20306]
651336032
HMPREF0991_02185
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA] 643146512
PROVALCAL_02194
transcriptional
antiterminator,
BglG family/PTS
system IIA
component
[Providencia
alcalifaciens
DSM 30120]
650533314
CLS_11430
putative efflux
protein, MATE
family
[Clostridium cf.
saccharolyticum
K10]
647875042
HMPREF0103_0968
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_33B]
651349618
HMPREF0992_01784
hypothetical
prote in
[Lachnospiraceae
bacterium
6_1_63FAA]
650047686
HMPREF1026_00380
MATE efflux
family protein
[Lachnospiraceae
bacterium sp.
8_1_57FAA]
651383759
HMPREF9477_01022
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_46FAA]
646287048
HMPREF0619_01585
ATP-dependent
DNA helicase
PcrA
[Parabacteroides
sp. D13]
651366176
HMPREF1025_00079
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
646240911
MBAG_00748
major facilitator
superfamily
transporter
[Coprobacillus
sp. D7]
646265588
HWAG_00962
g lutath ione-regulated
potassium-efflux
system protein
KefB
[Helicobacter
winghamensis
ATCC BAA-430]
645965094
FulcA4_010100002237
MATE efflux
family protein
[Fusobacterium
ulcerans ATCC
49185]
648529146
HMPREF9536_03593
hypothetical
prote in
[Escherichia coli
MS 84-1]
643114899
CLONEX_02408
hypothetical
prote in
[Clostridium
nexile DSM
1787]
643118148
CLOHIR_01360
Predicted
membrane
protein involved
in D-alanine
export
[Clostridium
hiranonis
TO-931 DSM
13275]
644146465
BACCOPRO_02796
NADH
dehydrogenase
subunit N (EC
1.6.5.3)
[Bacteroides
coprophilus
DSM 18228]
651568979
HMPREF9413_6003
putative sensory
transduction
protein RegX3
[Paenibacillus
sp. HGF7]
644170454
BACCELL_05618
Na -driven
multidrug efflux
pump
[Bacteroides
cellulosilyticus
DSM 14838]
644208763
CLOSTMETH_02720
hypothetical
prote in
[Clostridium
methylpentosum
R2, DSM 5476]
647782808
HMPREF5045_00261
cadmium-translocating
P-type ATPase
[Lactobacillus
crispatus
125-2-CHN]
646040243
ChatD1_010100029719
hypothetical
prote in
[Clostridium
hathewayi DSM
13479]
650351903
HMPREF9443_01683
putative stage V
sporulation
protein B
[Phascolarctobacterium
sp. YIT 12067]
646243919
CSAG_00301
ABC transporter
integral
membrane
prote in
[Citrobacter sp.
30_2]
651336522
HMPREF0991_02662
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
650350700
HMPREF9443_00480
FtsK/SpoIIIE
family protein
[Phascolarctobacterium
sp. YIT 12067]
650550088
ERE_13120
Histidine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Eubacterium
recta le M104/1]
646242203
MBAG_02014
diguanylate
cyclase
[Coprobacillus
sp. D7]
644177523
CLOSTASPAR_02138
transporter,
CPA2 family
(2.A.37)
[Clostridium
asparagiforme
DSM 15981]
644226964
EUBHAL_01409
Cell
wall-associated
hydrolases
(invasion-associated
proteins)
[Eubacterium
hallii DSM 3353]
650542908
ENC_28030
Uncharacterized
iron-regulated
membrane
prote in
[Enterobacter
cloacae cloacae
NCTC 9394]
644145598
BACCOPRO_01928
hypothetical
prote in
[Bacteroides
coprophilus
DSM 18228]
647369615
EDWATA_02346
transport
prote in
[Edwardsiella
tarda ATCC
23685]
646040376
ChatD1_010100030384
xanth ine
permease
[Clostridium
hathewayi DSM
13479]
648925962
HMPREF0326_00692
response
regulator
[Desulfovibrio
sp. 3_1_syn3]
647899552
HMPREF0969_03447
conserved
hypothetical
prote in
[Bacteroides sp.
D20]
651571802
HMPREF9413_4024
putative
membrane
prote in
[Paenibacillus
sp. HGF7]
650544091
ENC_42820
Arabinose efflux
permease
[Enterobacter
cloacae cloacae
NCTC 9394]
648691048
HMPREF9521_02896
glycosyl
hydrolase family
25
[Enterococcus
faecalis
TX2134]
644157232
RUMHYD_02905
a lpha-1,4-g lucan:a lpha-1,4-g lucan
6-glycosyltransferase
[Blautia
hydrogenotrophica
DSM 10507]
647449955
CUW_0043
MATE efflux
family protein
[Turicibacter
sanguinis
PC909]
650045209
HMPREF1023_00881
hypothetical
prote in
[Eggerthella sp.
1_3_56FAA] 644177011
CLOSTASPAR_01626
hypothetical
prote in
[Clostridium
asparagiforme
DSM 15981] 644145549
BACCOPRO_01879
Uncharacterized
protein involved
in outer
membrane
biogenesis
[Bacteroides
coprophilus
DSM 18228]
651517676
HMPREF9412_1948
putative protein
LplC
[Paenibacillus
sp. HGF5]
651547410
HMPREF9538_01171
n itrite extrusion
prote in 2
[Klebsiella sp.
MS 92-3]
651568669
HMPREF9413_0248
methyl-accepting
chemotaxis
prote in
signaling
domain prote in
[Paenibacillus
sp. HGF7]
650575472
RUM_21390
Archaeal/vacuolar-type
H -ATPase
subunit I
[Ruminococcus
sp. 18P13]
646273991
BSIG_00838
conserved
hypothetical
prote in
[Bacteroides sp.
1_1_6]
651339575
HMPREF0994_02150
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650542442
ENC_22200 PTS
system,
glucose-like IIB
component
[Enterobacter
cloacae cloacae
NCTC 9394]
651567462
HMPREF9413_1447
stage V
sporulation
protein B
[Paenibacillus
sp. HGF7]
650574138
RUM_06270
Stage II
sporulation
protein E
(SpoIIE).
[Ruminococcus
sp. 18P13]
650352082
HMPREF9443_01863
bacterial type
II/III secretion
system short
domain prote in
[Phascolarctobacterium
sp. YIT 12067]
646003309
BacD2_010100003122
putative
transmembrane
prote in
[Bacteroides sp.
D2]
646038272
ChatD1_010100019755
major facilitator
superfamily
permease
[Clostridium
hathewayi DSM
13479]
647370136
EDWATA_02867
cytochrome
c- type
biogenesis
protein CcmF
[Edwardsiella
tarda ATCC
23685]
650022855
HMPREF1004_04308
response
regulator
[Ralstonia sp.
5_7_47FAA]
650320660
HMPREF9420_1857
flippase
[Prevotella
salivae DSM
15606]
650045819
HMPREF1023_01483
membrane
transporter
[Eggerthella sp.
1_3_56FAA]
648912016
HMPREF9008_04562
TraG family
prote in
[Bacteroides sp.
20_3] 643123818
BACDOR_04729
hypothetical
prote in
[Bacteroides
dorei DSM
17855]
650088494
HMPREF9464_01665
cytochrome bd
ubiqu ino l
oxidase subunit
I [Sutterella
wadsworthensis
3_1_45B]
644159132
HOLDEFILI_00875
Na -dependent
transporters of
the SNF family
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
650353181
HMPREF9444_00763
transporter,
major facilitator
family protein
[Succinatimonas
hippei YIT
12066]
643925642
HpulM9_010100008780
folylpolyglutamate
synthase
[Helicobacter
pullorum MIT
98-5489]
644272231
ROSEINA2194_03730
hypothetical
prote in
[Roseburia
inulinivorans
DSM 16841]
643921791
HcinC1_010100001645
cell division
membrane
prote in
FtsW/MrdB/SpoVE
[Helicobacter
cinaedi CCUG
18818]
647367858
EDWATA_00589
2-acylglycerophosphoethanolamine
acyltransferase/Acyl-[acyl-carrier-protein]
synthetase
[Edwardsiella
tarda ATCC
23685]
648928021
HMPREF0326_02726
molybdenum
cofactor
biosynthesis
protein B
[Desulfovibrio
sp. 3_1_syn3]
646287720
HMPREF0619_02250
TraG/TraD
family
mobilization
prote in
[Parabacteroides
sp. D13]
650043889
HMPREF1016_03453
glycosyltransferase
sugar-b ind ing
reg ion
containing DXD
domain-conta in ing
prote in
[Bacteroides
eggerthii
1_2_48FAA]
646265400
HWAG_00775
predicted
prote in
[Helicobacter
winghamensis
ATCC BAA-430]
646211598
ESAG_06846
predicted
prote in
[Escherichia sp.
3_2_53FAA]
651569563
HMPREF9413_1569
putative
transmembrane
permease MsmF
[Paenibacillus
sp. HGF7]
643145856
PROVALCAL_01535
hypothetical
prote in
[Providencia
alcalifaciens
DSM 30120]
650541884
ENC_14920
Putative
hemolysin
[Enterobacter
cloacae cloacae
NCTC 9394]
650019251
HMPREF1004_00705
DNA-bind ing
response
regulator
[Ralstonia sp.
5_7_47FAA]
651335090
HMPREF0991_01256
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
647450909
CUY_5307 type
I restriction
modification
DNA specificity
domain prote in
[Bacteroides
ovatus SD CMC
3f]
648690949
HMPREF9521_02797
ABC
transporter,
ATP-bind ing
prote in
[Enterococcus
faecalis
TX2134]
648925411
HMPREF0326_00147
precorrin-6Y
C5,15-methyltransferase
(decarboxylating)
[Desulfovibrio
sp. 3_1_syn3]
650062175
HMPREF0864_02745
mechanosensitive
ion channel
prote in
[Enterobacteriaceae
bacterium
9_2_54FAA]
646258712
OFAG_00688
predicted
prote in
[Oxalobacter
formigenes
HOxBLS]
646263286
HRAG_00966
predicted
prote in
[Helicobacter
bilis ATCC
43879]
646302773
HMPREF0026_00266
phosphate
regulon
transcriptional
regulatory
protein PhoB
[Acinetobacter
junii SH205] 646245985
CSAG_02333
stationary phase
inducible
protein CsiE
[Citrobacter sp.
30_2]
644327808
HMPREF0530_1639
conserved
hypothetical
prote in
[Lactobacillus
paracasei ATCC
25302]
648927401
HMPREF0326_02116
phosphatidate
cytidylyltransferase
[Desulfovibrio
sp. 3_1_syn3]
651341427
HMPREF0994_03996
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
647893390
HMPREF9024_01070
xylose-proton
symporter
[Pediococcus
acidilactici 7_4]
644166259
BACCELL_01422
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase./Response
regulator
receiver
domain./Two
component
regulator
propeller./Bacterial
regulatory
he l ix- turn-hel ix
proteins, AraC
family./Y_Y_Y
domain.
[Bacteroides
cellulosilyticus
DSM 14838]
647448178
CUW_0602
electron
transport
complex,
RnfABCDGE
type, D subunit
[Turicibacter
sanguinis
PC909]
646245210
CSAG_01569
major facilitator
superfamily
transporter
n itrite extrusion
prote in
[Citrobacter sp.
30_2]
644159851
HOLDEFILI_01595
Signal
transduction
histidine kinase
[Holdemania
filiformis VPI
J1-31B-1, DSM
12042]
646216963
BSAG_00356
d ipeptidyl
peptidase IV
[Bacteroides sp.
D1]
650078037
HMPREF9474_02090
hypothetical
prote in
[Clostridium
symbiosum
WAL-14163]
650198073
HMPREF0623_0793
response
regulator
[Pediococcus
acidilactici DSM
20284]
646304662
HMPREF0026_02113
glycerol
metabolism
activator
[Acinetobacter
junii SH205]
650082601
HMPREF9475_01905
transcriptional
regulatory
protein CutR
[Clostridium
symbiosum
WAL-14673]
647893557
HMPREF9024_01234
two-component
system, OmpR
family, response
regulator
[Pediococcus
acidilactici 7_4]
651344275
HMPREF0994_06806
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
648895179
HMPREF0106_04714
d ipeptidyl
aminopeptidase
IV [Bacteroides
sp. D22]
647457052
CW1_0738
d ipeptidyl
peptidase IV
N-terminal
domain prote in
[Bacteroides
ovatus SD CC
2a] 647878707
HMPREF0102_00604
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_22]
651370684
HMPREF0127_01576
hypothetical
prote in
[Bacteroides sp.
1_1_30]
651361498
HMPREF1018_00379
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
645276477
Bfra3_010100012818
putative
exported
beta-glucosidase
[Bacteroides
fragilis 3_1_12]
646269824
BSHG_01237
periplasmic
beta-glucosidase
[Bacteroides sp.
3_2_5]
647885284
HMPREF0101_02342
periplasmic
beta-glucosidase
[Bacteroides sp.
2_1_16]
647444376
CW3_2034
d ipeptidyl
peptidase IV
N-terminal
domain prote in
[Bacteroides
xylanisolvens
SD CC 1b]
644269555
ROSEINA2194_01052
Type IV
secretory
pathway, VirD4
components
[Roseburia
inulinivorans
DSM 16841]
643115290
CLONEX_02799
Type IV
secretory
pathway, VirD4
components
[Clostridium
nexile DSM
1787]
644268671
ROSEINA2194_00167
Type IV
secretory
pathway, VirD4
components
[Roseburia
inulinivorans
DSM 16841]
650573469
RBR_20630
Type IV
secretory
pathway, VirD4
components
[Ruminococcus
bromii L2-63]
651366701
HMPREF1025_00598
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_46FAA]
651343784
HMPREF0994_06319
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
650555387
FP2_09410
Type IV
secretory
pathway, VirD4
components
[Faecalibacterium
prausnitzii
L2-6]
650592616
CL3_29540
Type IV
secretory
pathway, VirD4
components
[Clostridiales
sp. SM4/1]
650047273
HMPREF1023_02910
hypothetical
prote in
[Eggerthella sp.
1_3_56FAA]
647884485
HMPREF0101_01555
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
650016069
HMPREF0996_00613
electron
transport
complex
[Lachnospiraceae
bacterium sp.
5_1_63FAA]
644289708
HMPREF0497_2796
response
regulator
[Lactobacillus
buchneri ATCC
11577]
644286064
HMPREF0496_2264
NhaP family Na
/H and K /H
antiporter
[Lactobacillus
brevis
gravesensis
ATCC 27305] 644286630
HMPREF0496_2822
response
regulator
[Lactobacillus
brevis
gravesensis
ATCC 27305]
646271171
BSHG_02571
conserved
hypothetical
prote in
[Bacteroides sp.
3_2_5]
650559216
FPR_20270
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Faecalibacterium
prausnitzii
SL3/3]
651363661
HMPREF1018_02517
hypothetical
prote in
[Bacteroides sp.
2_1_56FAA]
651554529
HMPREF9439_02076
hypothetical
prote in
[Parasutterella
excrementihominis
YIT 11859]
647370778
EDWATA_03511
3-deoxy-D-manno-octu losonic-acid
transferase
[Edwardsiella
tarda ATCC
23685]
650027667
HMPREF1011_01104
response
regulator
receiver
domain-conta in ing
prote in
[Anaerostipes
sp. 3_2_56FAA]
650543120
ENC_30710
Acyl-CoA
synthetases
(AMP-forming)/AMP-acid
ligases II
[Enterobacter
cloacae cloacae
NCTC 9394]
646246335
CSAG_02675
RecN
[Citrobacter sp.
30_2]
650073639
HMPREF9488_01617
mate efflux
family protein
[Coprobacillus
sp. 29_1]
644095634
PROPEN_00337
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Proteus
penneri ATCC
35198]
646233933
BSFG_01933
conserved
hypothetical
prote in
[Bacteroides sp.
4_3_47FAA]
651312573
HMPREF0240_01526
hypothetical
prote in
[Clostridium sp.
D5]
643158721
PRABACTJOHN_04351
Major Facilitator
Superfamily.
[Parabacteroides
johnsonii DSM
18315]
650077893
HMPREF9474_01946
efflux pump
component MtrF
[Clostridium
symbiosum
WAL-14163]
650083560
HMPREF9475_02849
efflux pump
component MtrF
[Clostridium
symbiosum
WAL-14673]
644293633
HMPREF0348_0459
TraG/TraD
family protein
[Enterococcus
faecalis
TX0104]
650582723
RTO_05270
Site-specific
recombinases,
DNA invertase
Pin homologs
[Ruminococcus
torques L2-14]
650352384
HMPREF9443_02165
hypothetical
prote in
[Phascolarctobacterium
sp. YIT 12067]
651313322
HMPREF0240_02285
TraG family
prote in
[Clostridium sp.
D5]
643919620
Cbac1_010100030427
putative
conjugal
transfer protein
[Clostridiales
sp. 1_7_47FAA]
651333849
HMPREF0991_00028
hypothetical
prote in
[Lachnospiraceae
bacterium
2_1_58FAA]
646035541
ChatD1_010100006011
putative
conjugal
transfer protein
[Clostridium
hathewayi DSM
13479]
651343233
HMPREF0994_05778
hypothetical
prote in
[Lachnospiraceae
bacterium
3_1_57FAA_CT1]
647453979
CUY_1136
heavy metal
e fflux pump,
CzcA family
[Bacteroides
ovatus SD CMC
3f]
644289056
HMPREF0497_2152
NhaP-type Na
/H and K /H
antiporter
[Lactobacillus
buchneri ATCC
11577]
650029832
HMPREF1011_03236
response
regulator
receiver
domain-conta in ing
prote in
[Anaerostipes
sp. 3_2_56FAA]
650003718
HMPREF9011_02241
integral
membrane
prote in
[Bacteroides sp.
3_1_40A]
644156166
RUMHYD_01839
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain [Blautia
hydrogenotrophica
DSM 10507]
650593988
CL2_12300
electron
transport
complex,
RnfABCDGE
type, D subunit
[Clostridiales
sp. SSC/2]
648925701
HMPREF0326_00435
FolD
b ifunctional
prote in
[Desulfovibrio
sp. 3_1_syn3]
648909320
HMPREF9008_02286
ABC transporter
permease
[Bacteroides sp.
20_3]
650319173
HMPREF9420_0396
sialic
acid-specific
9-O-acetylesterase
[Prevotella
salivae DSM
15606]
644287890
HMPREF0497_1034
hypothetical
prote in
[Lactobacillus
buchneri ATCC
11577]
643123401
BACDOR_04312
His Kinase A
(phosphoacceptor)
domain./Histid ine
kinase-, DNA
gyrase B-, and
HSP90-like
ATPase.
[Bacteroides
dorei DSM
17855]
646213174
BSBG_01486
two-component
system sensor
histidine kinase
[Bacteroides sp.
9_1_42FAA]
650596955
CK3_14330
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Clostridiales
sp. SS3/4]
650187136
HMPREF9436_00872
response
regulator
receiver domain
prote in
[Faecalibacterium
cf. prausnitzii
KLE1255]
646234983
BSFG_02970
two-component
system sensor
histidine kinase
[Bacteroides sp.
4_3_47FAA]
646227814
BSEG_00324
two-component
system sensor
histidine kinase
[Bacteroides
dore i
5_1_36/D4]
650556613
FP2_23710
Response
regulators
consisting of a
CheY-like
receiver domain
and a
winged-helix
DNA-bind ing
domain
[Faecalibacterium
prausnitzii
L2-6]
644294701
HMPREF0348_1506
conserved
hypothetical
prote in
[Enterococcus
faecalis
TX0104]
648924416
HMPREF0189_01216
conserved
hypothetical
prote in
[Burkholderiales
bacterium
1_1_47]
651356962
HMPREF1017_00998
hypothetical
prote in
[Bacteroides
ovatus
3_8_47FAA]
647451611
CUY_1029
polysaccharide
biosynthesis
prote in
[Bacteroides
ovatus SD CMC
3f]
647886305
HMPREF0101_03351
conserved
hypothetical
prote in
[Bacteroides sp.
2_1_16]
648691360
HMPREF9521_03208
hypothetical
prote in
[Enterococcus
faecalis
TX2134]
vs. human proteome vs. human microbiome
Induced Treg response
Example: HCV Vaccine
One “special” epitope: cross-reactive
19 EpiVax - Non-Confidential
Protein Group A, Variant 3
Protein Group A, Variant 1
Application to Protein Engineering
Protein Group A, Variant 2
Variant 3 Adjusted for
Tregitope and HG XR
Variant 1 Adjusted for
Tregitope and HG XR
Variant 2 Adjusted for
Tregitope and HG XR
Non-Confidential EpiVax
DeImmunization EpiVax - OptiMatrix
21
Select a different amino acid and see its effect immediately
EpiVax’s OptiMatrix tool allows the user to:
• Decrease potential immunogenicity of T cell epitopes by weakening “agretope” (interface with
HLA molecule)
• identify and iteratively modify key AA residues
• OptiMatrix provides a logo report which shows the contribution of each amino acid to overall
immunogenicity of the peptide
• Change any amino acid and see its affect on immunogenicity in real time
• “Best Single Change” function auto calculated the AA modification that results in the most
drastic decrease in predicted immunogenicity
http://bit.ly/EpiDeFT Non-Confidential EpiVax
OptiMatrix Interactive Peptide Deimmunization
22
Frame Frame DRB1*0101 DRB1*0301 DRB1*0401 DRB1*0701 DRB1*0801 DRB1*1101 DRB1*1301 DRB1*1501
Start Stop Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score Z-Score
254 PRGYFKIRT 262 -0.23 0
255 RGYFKIRTG 263 -0.2 0
256 GYFKIRTGK 264 -0.19 0
257 YFKIRTGKT 265 -0.9 2.38 2.41 2.51 1.4 2.2 1.98 5
258 FKIRTGKTT 266 -0.83 2.41 2.13 1.69 1.32 1.53 3
259 KIRTGKTTI 267 -0.14 1.44 0
260 IRTGKTTIM 268 0 1.97 1.42 1.48 1
261 RTGKTTIMR 269 -0.21 1.33 0
DRB1*0101 DRB1*0301 DRB1*0401 DRB1*0701 DRB1*0801 DRB1*1101 DRB1*1301 DRB1*1501 Total
2.41 1.97 2.41 2.51 1.69 2.2 1.48 1.98 --
4.79 1.97 2.41 4.64 1.69 2.2 0 1.98 19.68
2 1 1 2 1 1 0 1 9
Scores Adjusted for Tregitope: -- EpiMatrix Score: 13.08 EpiMatrix Score (w/o flanks): 16.05
Sum of Significant Z scores
Count of Significant Z Scores
Total Assessments Performed: 64 Hydrophobicity: -0.84 EpiMatrix Score: 13.08 EpiMatrix Score (w/o flanks): 16.05
AA SequenceHydro-
phobicityHits
Summarized Results (25-SEP-2009)
Maximum Single Z score
OptiMatrix:
22 http://bit.ly/EpiDeFT Non-Confidential EpiVax
OptiMatrix See the effects of amino acid substitution in real-time
Confidential 23
OptiMatrix:
Click multiple times to continue deimmunizing
23 http://bit.ly/EpiDeFT Non-Confidential EpiVax
24
High Throughput Analysis EpiVax
The High-Throughput analysis allows users to compare a large number potential
antibody candidates by ranking the immunogenicity of heavy and light chains.
http://www.epivax.com/immunogenicity-screening/ht_report/ Non-Confidential EpiVax
Expert Consulting Services EpiVax
25
Algorithms only go so far in immunogenicity prediction – immunoinformatics
expertise is the greatest tool contained in the ISPRI system. We have worked with
the ISPRI tools since 1998 and can help interpret the data for your team.
Annie De Groot, MD (CEO) William Martin (CIO)
http://www.epivax.com/about/epivax-team/ Non-Confidential EpiVax
In Silico Immunogenicity
Screening Services
26
ISPRI Website: Cloud-based Interactive Protein Screening and Reengineering
Interface, leased to large pharma world-wide. Your scientists use ISPRI to predict
overall and regional immunogenicity. Available for annual lease for a set number of
protein sequences (Limited) or Unlimited Sequences. Includes continued
consultation and training with experts at EpiVax. http://bit.ly/ISPRI
PreDeFT: Highly detailed in silico immunogenicity analysis covering overall and
regional immunogenic potential of a protein therapeutic. Delivered as a “FDA
ready” report. EpiVax “IMF” team uses ISPRI for you. http://bit.ly/PreDeFT
HT Screening: High-throughput immunogenicity screening of large sets of
antibody heavy-light chain combinations, for overall and comparative immunogenic
potential. http://bit.ly/PreDeFTht
DeFT: (Deimmunization of a Functional Therapeutic) is a tested process of
analysis, reengineering and confirmation. http://bit.ly/EpiDeFT
Sales contacts: [email protected] (US/other) or [email protected] (EUR)
Published Validation
27
Correlation of EpiMatrix Scores and Immunogenicity in Human studies
40%
37%
21.97
FPX 1
0%
9.3%
-111.25
FPX 5
NA 0.5% 12% Neutralizing
Antibodies
5.6% 7.8% 53% Binding Antibodies
-1.76 1.62 34.37 EpiMatrix score
FPX 4 FPX 3 FPX 2 Protein
Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein (2007). PDF HERE
Negative score indicates presence of Treg epitope
ISPRI Validation in Print (A Sample)
29
Koren E, De Groot AS, Jawa V, Beck KD, Boone T, Rivera D, Li L, Mytych D,
Koscec M, Weeraratne D, Swanson S, Martin W. Clinical validation of the “in
silico” prediction of immunogenicity of a human recombinant therapeutic protein
Clin Immunol. 2007 Jul. http://bit.ly/epiClinVal
De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less
immunogenic protein therapeutics. Clin Immunol. 2009 May;131(2):189-201.
http://bit.ly/epiClinIm
Jawa, V., Cousens, L., & De Groot, A. S. (2013). Immunogenicity of Therapeutic
Fusion proteins: Contributory Factors and Clinical Experience. Fusion Protein
Technologies for Biopharmaceuticals: Applications and Challenges, 75-90.
http://bit.ly/epiFcFuse
Jawa V, Cousens LP, Awwad M, Wakshull E, Kropshofer H, De Groot AS. T-cell
dependent immunogenicity of protein therapeutics: Preclinical assessment and
mitigation http://bit.ly/The_TCWP
Non-Confidential EpiVax
30
1: De Groot AS, Ardito M, Terry F, Levitz L, Ross T, Moise L, Martin W. Low immunogenicity predicted for emerging avian-origin H7N9:
implication for influenza vaccine design. Hum Vaccin Immunother. 2013 May;9(5):950-6. doi: 10.4161/hv.24939. Epub 2013 May 1. PubMed PMID:
23807079; PubMed Central PMCID: PMC3899161.
2: Cousens LP, Tassone R, Mazer BD, Ramachandiran V, Scott DW, De Groot AS. Tregitope update: mechanism of action parallels IVIg.
Autoimmun Rev. 2013 Jan;12(3):436-43. doi: 10.1016/j.autrev.2012.08.017. Epub 2012 Aug 28. Review. PubMed PMID: 22944299.
3: De Groot AS, Cousens L, Mingozzi F, Martin W. Tregitope peptides: the active pharmaceutical ingredient of IVIG? Clin Dev Immunol.
2013;2013:493138. doi: 10.1155/2013/493138. Epub 2013 Dec 25. PubMed PMID: 24454476; PubMed Central PMCID: PMC3886585.
4: Cou5sens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS. In
vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity.
J Clin Immunol. 2013 Jan;33 Suppl 1:S43-9. doi: 10.1007/s10875-012-9762-4. Epub 2012 Sep 2. Review. PubMed PMID: 22941509; PubMed
Central PMCID: PMC3538121.
5: Jawa V, Cousens LP, Awwad M, Wakshull E, Kropshofer H, De Groot AS. T-cell dependent immunogenicity of protein therapeutics:
Preclinical assessment and mitigation. Clin Immunol. 2013 Dec;149(3):534-55. doi: 10.1016/j.clim.2013.09.006. Epub 2013 Sep 25. Review.
PubMed PMID: 24263283.
6: De Groot AS, Terry F, Cousens L, Martin W. Beyond humanization and de-immunization: tolerization as a method for reducing the
immunogenicity of biologics. Expert Rev Clin Pharmacol. 2013 Nov;6(6):651-62. doi: 10.1586/17512433.2013.835698. PubMed PMID:
24164613.
7: Hui DJ, Basner-Tschakarjan E, Chen Y, Davidson RJ, Buchlis G, Yazicioglu M, Pien GC, Finn JD, Haurigot V, Tai A, Scott DW, Cousens LP, Zhou
S, De Groot AS, Mingozzi F. Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes. Mol Ther. 2013
Sep;21(9):1727-37. doi:
8.1038/mt.2013.166. Epub 2013 Jul 16. PubMed PMID: 23857231. 4: Su Y, Rossi R, De Groot AS, Scott DW. Regulatory T cell epitopes
(Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se. J Leukoc Biol. 2013 Aug;94(2):377-83. doi:
10.1189/jlb.0912441. Epub 2013 May 31. PubMed PMID: 23729499.
9: Moise L, Gutierrez AH, Bailey-Kellogg C, Terry F, Leng Q, Abdel Hady KM, VerBerkmoes NC, Sztein MB, Losikoff PT, Martin WD, Rothman AL,
De Groot AS. The two-faced T cell epitope: examining the host-microbe interface with JanusMatrix. Hum Vaccin Immunother. 2013 Jul;9(7):1577-
86. doi: 10.4161/hv.24615. Epub 2013 Apr 12. PubMed PMID.
10: Cousens LP, Su Y, McClaine E, Li X, Terry F, Smith R, Lee J, Martin W, Scott DW, De Groot AS. Application of IgG-derived natural Treg
epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes. J Diabetes Res. 2013;2013:621693.
doi: 10.1155/2013/621693. Epub 2013 Apr 23. PubMed PMID: 23710469; 11: Elfaki ME, Khalil EA, De Groot AS, Musa AM, Gutierrez A, Younis BM,
Salih KA, El-Hassan AM. Immunogenicity and immune modulatory effects of in silico predicted L. donovani candidate peptide vaccines. Hum
Vaccin Immunother. 2012 Dec 1;8(12):1769-74. doi: 10.4161/hv.21881. Epub 2012 Aug 24. PubMed PMID: 22922767; PubMed Central
12: Cousens LP, Mingozzi F, van der Marel S, Su Y, Garman R, Ferreira V, Martin W, Scott DW, De Groot AS. Teaching tolerance: New
approaches to enzyme replacement therapy for Pompe disease. Hum Vaccin Immunother. 2012 Oct;8(10):1459-64. doi: 10.4161/hv.21405.
Epub 2012 Oct 1. PubMed PMID: 23095864; PubMed
13. Gutiérrez AH, Moise L, De Groot AS. Of [Hamsters] and men: a new perspective on host cell proteins. Hum Vaccin Immunother. 2012
Sep;8(9):1172-4. doi: 10.4161/hv.22378. Epub 2012 Sep 1. PubMed PMID: 23124469; PubMed Central PMCID: PMC3579895.
14: van der Marel S, Majowicz A, Kwikkers K, van Logtenstein R, te Velde AA, De Groot AS, Meijer SL, van Deventer SJ, Petry H, Hommes DW,
Ferreira V. Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World J Gastroenterol. 2012 Aug
28;18(32):4288-99. doi: 10.3748/wjg.v18.i32.4288. PubMed PMID: 22969191.
15: Moise L, Song C, Martin WD, Tassone R, De Groot AS, Scott DW. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in
vivo. Clin Immunol. 2012 Mar;142(3):320-31. doi: 10.1016/j.clim.2011.11.010. Epub 2011 Dec 8. PubMed PMID: 22222093; PubMed Central
PMCID: PMC3288193.
16: Inaba H, Martin W, Ardito M, De Groot AS, De Groot LJ. The role of glutamic or aspartic acid in position four of the epitope binding motif and
thyrotropin receptor-extracellular domain epitope selection in Graves' disease. J Clin Endocrinol Metab. 2010 Jun;95(6):2909-16. doi:
10.1210/jc.2009-2393. Epub 2010 Apr 14. PubMed PMID: 20392871; PubMed Central
17: De Groot AS, Baker M, Cohen T. Species neutral correlates of immunogenicity for vaccines and protein therapeutics: fact or science fiction.
Hum Vaccin. 2010 May;6(5):371.
18: Scott DW, De Groot AS. Can we prevent immunogenicity of human protein drugs? Ann Rheum Dis. 2010 Jan;69 Suppl 1:i72-76. doi:
10.1136/ard.2009.117564. Review.
19: Cohen T, Moise L, Ardito M, Martin W, De Groot AS. A method for individualizing the prediction of immunogenicity of protein vaccines and
biologic therapeutics: individualized T cell epitope measure (iTEM). J Biomed Biotechnol. 2010;2010. pii: 961752. doi: 10.1155/2010/961752. Epub
2010 Jul 18. PubMed PMID: 20706613; PubMed Central PMCID:
20: De Groot AS. Exploring the immunome: A brave new world for human vaccine development. Hum Vaccin. 2009 Dec;5(12):790-3. Epub 2009 Dec
15. PubMed PMID: 20009527.
21: Weber CA, Mehta PJ, Ardito M, Moise L, Martin B, De Groot AS. T cell epitope: friend or foe? Immunogenicity of biologics in context. Adv Drug
Deliv Rev. 2009 Sep 30;61(11):965-76. doi: 10.1016/j.addr.2009.07.001. Epub 2009 Jul 18. Review. PubMed PMID: 19619593.
22: De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol. 2009
May;131(2):189-201. doi: 10.1016/j.clim.2009.01.009. Epub 2009 Mar 6. Review. PubMed PMID: 19269256. 23: De Groot AS, Moise L, McMurry JA,
Wambre E, Van Overtvelt L, Moingeon P, Scott DW, Martin W. Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes". Blood.
2008 Oct 15;112(8):3303-11. doi: 10.1182/blood-2008-02-138073. Epub 2008 Jul 25. .
24: De Groot AS, McMurry J, Moise L. Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates. Curr Opin Pharmacol. 2008
Oct;8(5):620-6. doi: 10.1016/j.coph.2008.08.002. Epub 2008 Sep 19. Review. PubMed PMID: 18775515.
25: De Groot AS, Scott DW. Immunogenicity of protein therapeutics. Trends Immunol. 2007 Nov;28(11):482-90. Epub 2007 Oct 25. Review.
PubMed PMID: 17964218. 26: De Groot AS, Moise L. Prediction of immunogenicity for therapeutic proteins: state of the art. Curr Opin Drug Discov
Devel. 2007 May;10(3):332-40. Review. PubMed PMID: 17554860.
27: De Groot AS, Goldberg M, Moise L, Martin W. Evolutionary deimmunization: an ancillary mechanism for self-tolerance? Cell Immunol. 2006
Dec;244(2):148-53. Epub 2007 Apr 18. 28: De Groot AS. Immunomics: discovering new targets for vaccines and therapeutics. Drug Discov Today.
2006 Mar;11(5-6):203-9. Review. PubMed PMID: 6580597.
29: De Groot AS, Knopp PM, Martin W. De-immunization of therapeutic proteins by T-cell epitope modification. Dev Biol (Basel). 2005;122:171-94.
Review. PubMed PMID: 16375261.
30: De Groot AS, Rayner J, Martin W. Modelling the immunogenicity of therapeutic proteins using T cell epitope mapping. Dev Biol (Basel).
2003;112:71-80. PubMed PMID: 12762506.
Published Validation EpiVax: > 60 Publications in Protein Therapeutics
http://www.epivax.com/publications/
EpiVax Services
31 http://www.epivax.com/ Non-Confidential EpiVax
32
CIO/DIRECTOR OF BIOINFORMATICS Bill Martin [email protected]
BIOINFORMATICS PROGRAM MANAGER Frances Terry [email protected]
BIOINFORMATICS PROGRAMMER/ANALYST Jacob Tivin [email protected]
EpiVax “Genius” Team
BDA – SALES INQUIRES Anthony Marcello [email protected] Phoebe De Groot De [email protected]
Accessing the Tools Contact Jason Del Pozzo: [email protected]
Confidential 33
PreDeFT: Fee for service in silico immunogenicity analysis. Performed on a protein by protein basis. Pricing based on length of sequence(s).
Limited ISPRI Website: Limited access to EpiVax’ Interactive Protein Screening and Reengineering Interface. Available for set numbers of proteins.
Unlimited ISPRI Website: Unlimited access to EpiVax’ Interactive Protein Screening and Reengineering Interface. Available in three year lease periods.
Fee for Service: HLA Binding Assays, HLA Transgenic Mice, ELISpot Assays.