eric bonnet computational systems biology of cancer institut curie - inserm u900 - mines paristech
DESCRIPTION
BiNoM 2.0, a versatile tool for accessing and analyzing pathways using standard systems biology formats. Eric Bonnet Computational Systems Biology of Cancer Institut Curie - INSERM U900 - Mines ParisTech http://sysbio.curie.fr Workshop NUS-IBENS 30/05/2013. Pathway databases. - PowerPoint PPT PresentationTRANSCRIPT
BiNoM 2.0, a versatile tool for accessing and analyzing pathways using standard systems biology formats
Eric BonnetComputational Systems Biology of Cancer
Institut Curie - INSERM U900 - Mines ParisTech
http://sysbio.curie.fr
Workshop NUS-IBENS 30/05/2013
Pathway databases
Molecular reactions maps
RB / E2F map
Standard formats
BiNoM, a Biological Network Manager
• Supports standard systems biology formats (BioPAX, CellDesigner, etc.).
• Facilitates the visualization and manipulation of biological networks.
• Help the user to analyze, extract and condense network information.
BiNoM Utilities
BiNoM Structure analysis
BiNoM BioPAX Query
BiNoM I/O
BiNoM BioPAXUtilities
BiNoM Modules
Use of data from public pathway databases for modelling purposes (from Bauer-Mehren et al., Pathway databases and tools for their exploitatation: benefits, current limitations and challenges. 2009 Molecular Systems Biology 5:290).
BiNoM
Modular representation
RB / E2F network, 70+ proteins, 160+ reactions, 350 publications
Modular representation
Invasive cancersNon-invasive cancers
• Influence graph G.• Input nodes I1, I2.• Output (target) node O1.
I1 -> B -> C -> O1I1 -> E -> C -> O1I2 -> E -> C -> O1
• Combinations of Interventions:
{C}, {E, B}, {I1, I2}
• Application of OCSANA: candidate drug targets discovery.
OCSANA: Optimal Combinations of Interventions for Network Analysis
OCSANA CI search algorithms
• Finding CIs is a combinatorial problem.
• Berge’s algorithm (1989)
• Recursive calculation of transervals on a hypergraph.
• Exact and complete, but do not scale well for networks 50+ nodes.
• Approximation solution.
• Use a score to reduce the search space.
• Score is based on the network structure.
BiNoM Team
Laurence Calzone
Daniel Rovera
Gautier Stoll
Paola Vera-Licona
Emmanuel Barillot
Andrei Zinovyev
http://binom.curie.fr
http://apps.cytoscape.org/apps/binom