A Liquid/Video AFM study of MMR

A Fluid/Video AFM study of MMREries LabZimeng Li2012-2-29ContentQuestionsFeasibilityProblems and SolutionsVideo/Fluid AFMQuestionsSliding clamp modelImprove image resolutionStudy orders in the pathwayDifferentiation of protein complexWhat else?FeasibilityPhysical blockageAFM scanning speed

Same DNA, or not the same DNA, during DNA movement image comparison4Known Problems and SolutionsWater constantly dryingInjection of reactantsConstant translational movementWater constantly dryingClosed Fluid CellDrop water

Injection of reactantsClosed Fluid CellNeedle Injection

Constant translational movement

Constant translational movementGlueMagnetSimultaneously move scan area

Video AFMFluid AFM

Video AFM

Fluid AFMSamples still attached to surfaceTips interacting with sampleCantilever drive frequency is coupled with fluid relaxation frequency

Dependent on fluid condition12To-dos