escalamiento en biorreactores
TRANSCRIPT
3.
AG
ITA
TIO
NO
FB
IOR
EA
CTO
RS
YS
TEM
S
●F
ig.
3.1
sh
ow
s t
he
dim
en
sio
ns
of
wh
at
is c
alle
da
“s
tan
da
rd” s
tirr
ed
ta
nk
bio
rea
cto
r v
es
se
lw
ith
B
aff
les.
FIG
.3.1
.S
tan
dard
Sti
rred
Tan
kB
iore
acto
r G
eom
etr
y[A
dop
ted
from
S.
Aib
a,
A.E
.H
um
ph
rey
an
dN
.F.
Millis.
“B
ub
ble
Aerati
on
an
dM
ech
an
icalA
git
ati
on
”.
In B
ioch
em
icalEn
gin
eeri
ng
,2
nd
Ed
.,A
cad
em
ic
Ge
om
etr
icR
atio
s f
or
a S
tand
ard
Bio
rea
cto
r
Ve
sse
lIm
peller
Di/D
tH
L/D
tL
i/Di
Wi/D
iH
b/D
iW
b/D
tN
o.
Baff
les
Typ
e
Fla
t-B
lad
e0.3
31
.00
.25
0.2
1.0
0.1
4
Tu
rbin
e
Pad
dle
0.
33
1.0
-0
.25
1.0
0.1
4
imp
eller
Mari
ne
0.3
31.0
pit
ch
=D
i1.0
0.1
4
Pro
peller
Wh
ere:
Dt=
tan
kd
iam
ete
r,
HL=
liq
uid
heig
ht
Di=
imp
eller
dia
mete
r
Hb=
im
peller
dis
tan
ce
from
bott
om
of
vessel
FIG
. 3.2
A.
Dif
fere
nt
Imp
eller
Typ
es.
(a)
Mari
ne-t
yp
ep
rop
ellers
;(b
)Fla
t-b
lad
etu
rbin
e,
Wi=
Di/5.
© D
isk f
lat-
bla
de
turb
ine,
Wi=
Di/5,
Di=
2D
t/3,
Li=
Di/4;
(d)
Cu
rved
-
bla
de
turb
ine,
Wi=
Di/3;
(e)
Pit
ch
ed
-bla
de
turb
ine,
Wi=
Di/8;
FIG
.3.2
B.
Mix
ing
Patt
ern
sfo
r Fla
t-B
lad
eTu
rbin
e I
mp
eller.
Eff
ect
of
Baff
les.
Liq
uid
ag
itati
on
in
pre
sen
ce o
fa
gas-l
iqu
idin
terf
ace,
wit
h
an
dw
ith
ou
tw
ail
baff
les:
(a)
Mari
ne im
peller
an
d(b
)D
isk
flat-
bla
de
turb
ines;
(c)
infu
llvessels
wit
hou
ta
gas-l
iqu
idin
terf
ace (
con
tin
uou
sfl
ow
)an
dw
ith
ou
t b
aff
les.
3.1
Mix
ing
an
d P
ow
er
Req
uir
em
en
tsfo
r N
ew
ton
ian
Flu
ids
ina
Sti
rred
Tan
k
FIG
.3.3
NP
vs.
NR
e;
the
pow
er
ch
ara
cte
risti
cs
are
sh
ow
nb
yth
ep
ow
er
nu
mb
er,
NP,
an
dth
em
od
ifie
dR
eyn
old
sn
um
ber,
NR
e,
of
sin
gle
imp
ellers
on
ash
aft
.[A
dop
ted
from
S.
Aib
a,
A.E
.H
um
ph
rey
an
dN
.F.
Millis.
“B
ub
ble
Aerati
on
an
dM
ech
an
icalA
git
ati
on
”.
In B
ioch
em
ical
En
gin
eeri
ng
,2n
dEd
.,A
cad
em
icP
ress,
Inc.,
New
York
(1973)
174].
Fig
.3.3
sh
ow
sre
lati
on
sh
ipb
etw
een
NPan
d
NRe
at
thre
ed
iffe
ren
tfl
ow
reg
imes:
●Lam
inar
●Tra
nsie
nt
●Fu
lly
Tu
rbu
len
t
for
thre
e d
iffe
ren
t im
peller
typ
es:
●S
ix-b
lad
ed
flat
bla
de t
urb
ine
●P
ad
dle
imp
eller
●M
ari
ne
Pro
peller
Th
e p
ow
er
nu
mb
er
isg
iven
by
Eq
u.
3.1
NP=
Pg
c/n
3 Di5 ρ
……
……
……
……
…(3
.1)
Th
eim
peller
Reyn
old
s
nu
mb
er
is g
iven
by
Eq
u.
3.2
NRe
= n
Di2 ρ
/µ…
……
……
....
....
....
....
..(3
.2)
Wh
ere
:N
=d
imen
sio
nle
ss
Reyn
old
s