etb funding success case: starlab - eurotransbio funding success case: starlab aureli soria-frisch...
TRANSCRIPT
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Starlab Neuroscience
ETB Funding Success Case: Starlab Aureli Soria-Frisch (PhD)
Senior Researcher and Neuroscience Research Program Manager
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Starlab – a brief introduction
• A private R&D company based in Barcelona
•We transform Science into Technologies for our Clients
•We develop new products and services with profound and positive social impact
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE3
| STARLAB BARCELONA | LIVING SCIENCE ! STARLAB NEUROSCIENCE!
Starlab – a brief introduction!
3!
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products
• snow detec+on• jellyfish predic+on• smart irriga+on
• electrophysiology• electrical brain s+mula+on
R+D
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Neuroscience Research – What we offer
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Less of this ...
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Neuroscience Research – What we offer
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Less of this ...More of this!
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Neuroscience Research – What we offer
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Less of this ...More of this!
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Neuroscience Research – What we offer
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Physiological Data Analysis• Protocol defini+on• Data collec+on• Data cleaning and ar+fact removal• Feature extrac+on and valida+on• Effect classifica+on• Study valida+on• Data Analysis Support for Experimental Work and Clinical Trials
Physiological Sensor Systems• Requirements analysis• Electronic design• Industrial design• Fast prototyping• Test and valida+on
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Algorithms• Signal Processing• Computa+onal Intelligence• Machine Learning• Data-‐mining• Modeling and simula+on• Data fusion and integra+on
| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE8
NeuroscienceNeuroscience - Know-how
Hardware• Fast prototyping• Sensor technologies• Embedded systems• Wireless communica+ons• Industrial design
EEGtCS
SUENO
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE8
Funded Research
• Building prototypes• Ideas harves@ng• Exploring new territories
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
NeuroscienceFunded Research
user state
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BCI
physiologicalbiometrics
Application Areas
brain sCmulaCon
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE11
CombinationBCI withAssistive Technologies
• Motor imagery• SSVEP• EOG, EMG based
Brain Computer Interfaces
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Biometry
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Brain Electrical Stimulation
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE14
Changes in the Comma Recovery Scale aEer tDCS
Brain Electrical Stimulation
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE15
EEG biomarkers
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
EEG biomarkers
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We use EEG features to predict Parkinson’s 10years in advance
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
User State
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
User State
• Emotional state• Stress• Sleep\Alertness• Mental Workload
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
SUENO project - goals
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• Sleep analysis through electrophysiological signals‣ Automate algorithms for sleep
analysis‣ Further development of
electrophysiological sensor device
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
SUENO project - work plan
WP1SoA and
requirements
WP2Algorithms development
WP3Device
development
WP4Experimental valida+on
WP5Market analysis
WP6Project
management
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
WP3 Device development
• Original electrophysiological device - Enobio• Frontal electrodes• Band cap for electrode positioning• System was not suitable for sleep studies
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
• First development - Enobio 2G• New electrode design in order to allow hair areas positioning• New electrode cap for full scalp monitoring
WP3 Device development
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
WP4 Validation
• Recording campaigns‣ Sleep Dept. Sabadell Hospital – C.S. Parc Taulí‣ Siesta Group
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
• Validation proposed improvements‣ Improve communication stability‣ Place somewhere else electronic box‣ Improve electrode holder to avoid contact loss during night‣ Nice to have dry electrodes to reduce preparation time
WP3 Device development
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
• Final validation ‣ System is validated for detection of sleep macrostructure -
performance equal to standard systems‣ For sleep microstructures detection further improvements are
needed• Final device features - Enobio 3G
‣ Standard Bluetooth communication‣ Larger capability - 20 channels at 500 Hz‣ Improved and more flexible electrode cap‣ Dry electrodes
WP4 Validation
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Enobio 3G
• Wearable• Wireless• Easy to Use
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Neuroelectrics in a nutshell…
Date of foundation: May 2011.
Headquarters: Barcelona, Spain.
CEO: Ana Maiques.
Staff: 4.
Aim: Investigate, develop and market products in the neuroscience area.
Mission:
“To become the trusted leader in Brain Health treatment by providing measurement tools and
making neuromodulation affordable and available for every patient in need”.
General facts
The company has two products:• Enobio: a wireless electroencefalograpy
system, monitoring brain activity in an easy way and already in the market
• Starstim: a novel neurostimulator using tDCS-transcraneal direct current stimulation to treat, amongst others:
• Chronic Pain• Post-Stroke Rehabilitation
Company focus
2
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE28
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Enobio new family of products.
4
TARGET MARKETS: Research (CE since Feb 2012) and Medical (CE Medical since April 2012)
20832 on the pipeline
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Signals you can trustFaithful reproduction of the raw EEG signal.Get the reliability of a wired system without the wiresCapture all the data you need
Quality EEG made easyStart recording in less than one minuteEasily visualize and manage your dataRecord where and when you want
Advanced development toolsWork with raw dataBuild your own applicationsSafeguard and organize your research
Features
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NIC visualization and analysis software:• User-friendly EEG visualization• Intuitive time-frequency analysis• Customizable user interface
Software
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE32
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
EEG biomarkers
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Parkinsonʼs
Alzheimerʼs
ADHD
Schizophrenia
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
EEG biomarkers
33
Parkinsonʼs
Alzheimerʼs
ADHD
Schizophrenia
Diagnosis
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
EEG biomarkers
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Parkinsonʼs
Alzheimerʼs
ADHD
Schizophrenia
Diagnosis
Prognosis
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Physiological Data Consulting Service
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data
largest informa+onat reduced costs
automate knowledgegenera+on
summaryreport
hypothesislaunching
Data analysis partnerfor pharma industry
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Cognitive Enhancement
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Study at Oxford University: tDCS for math skill boos+ng
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Cognitive Enhancement
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Demen@a
Study at Oxford University: tDCS for math skill boos+ng
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Cognitive Enhancement
35
Demen@amTBI
Study at Oxford University: tDCS for math skill boos+ng
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Cognitive Enhancement
35
Demen@amTBIHealthy subjects?
Study at Oxford University: tDCS for math skill boos+ng
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Cognitive Enhancement
35
Demen@amTBIHealthy subjects?Study aid?
Study at Oxford University: tDCS for math skill boos+ng
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Sports Performance
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
Neuromarketing
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Mul+-‐modal emo+on recogni+on: We gather emo+onal response of subjects by using electrophysiological sensors and facial expression recogni+on
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
tCS Applications enter mainstream
• Chronic pain• Depression• Post-stroke rehabilitation• Dementia• Addiction• …
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Pilot using tDCS for stroke rehabilita+on by our partners at Burke Rehabilita+on Centre
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| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE
tCS Applications enter mainstream
• Chronic pain• Depression• Post-stroke rehabilitation• Dementia• Addiction• …
• Improve therapies– Non-invasive– Safe– No known side effects– Precise targets
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Pilot using tDCS for stroke rehabilita+on by our partners at Burke Rehabilita+on Centre