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of advanced fibrosis in these pericentral gradient; iron is found predominantly in parenchymal

cells, and Kupffer cells are spared._ Absolute: active pathological bleeding (ICH, PUD)Heparin

Side eects: bleeding, thro!boc"topeniaContraindications_ Absolute: severe thro!boc"topenia

Avoid anticoagulation and #Pllb$llla inhibitorsAvoid non%steroidal agents&reat!ent 'or chest pain (does not respond to nitrogl"cerin)ed rest (si!ilar to acute I)onitor and treat 'or arrh"th!ias

specifc therapyn$a

ollow-upn$a

complications and prognosis*entricular aneur"s!+ate rupture

CADIAC &U-S

CADIAC &U-SPISCI++A HSU., D

history & physicalPrimary Cardiac Tumors / 012 benign, re!ainder are !alignantenign:Atrial !"3o!a_ !ost co!!on pri!ar" cardiac

_ Absolute: signi4cant aspirin allerg"ClopidogrelSide eects: bleeding, rash, rare neutropenia

Contraindicationst present, if patients have an elevated transferrin saturation or ferritin level,

genetic testing should be performed; if they are a C282Y homozygote or a compoundheterozygote (C282Y!"#$%, the diagnosis is confirmed. &f liver enzymes (alanine

aminotransferase ')*+, aspartate aminotransferase '*+% are elevated or the ferritin is

-/// 0g), the patient should be considered for liver biopsy because there is an increased

fre1uency of advanced fibrosis in these individuals. &f liver biopsy is performed, iron

deposition is found in a periportal distribution ith a periportal to pericentral gradient; iron is

found predominantly in parenchymal cells, and Kupffer cells are spared._ Absolute: active pathological bleeding (ICH, PUD)HeparinSide eects: bleeding, thro!boc"topenia

Contraindications_ Absolute: severe thro!boc"topenia

Avoid anticoagulation and #Pllb$llla inhibitorsAvoid non%steroidal agents&reat!ent 'or chest pain (does not respond to nitrogl"cerin)ed rest (si!ilar to acute I)onitor and treat 'or arrh"th!ias

specifc therapyn$a

ollow-upn$a

complications and prognosis*entricular aneur"s!+ate rupture

CADIAC &U-SPISCI++A HSU., D

history & physicalPrimary Cardiac Tumors / 012 benign, re!ainder are !alignantenign:

Atrial !"3o!a

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_ !ost co!!on pri!ar" cardiac

_ Absolute: signi4cant aspirin allerg"ClopidogrelSide eects: bleeding, rash, rare neutropeniaContraindications_ Absolute: active pathological bleeding (ICH, PUD)HeparinSide eects: bleeding, thro!boc"topenia

underta5e diagnostic studies6.arl" in'usion o' 'actor a'ter an" bleed reduces !orbidit"67oint bleeds do not re8uire aspiration unless pain and s9elling aresevere or unless sepsis is suspected6

specifc therapyanage!ent o' acute bleeding episodes in severe he!ophiliaAssess 9hether bleed is li'e%threatening (intracranial, retroperitoneal6retrophar"ngeal 9ith co!pro!ise o' air9a", !aortrau!a, !aor surger"), !aor (severe oint or so't tissue bleed,severe trau!a 9ithout evidence o' bleed, #I bleeding), or !inor(!ost oint and so't tissue bleeds, epista3is, dental bleeding)6

+i'e%threatening bleeds, replace to ;