ethics & prec prin 10/31/08 a small dose of toxicology a small dose of ethics uniting science,...
TRANSCRIPT
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
A Small Dose of Ethics
Uniting Science, Ethics, and Policy to Protect
Public Health
Steven G. Gilbert, PhD, DABTwww.asmalldoseof.org
www.toxipedia.org
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Child Health
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
• Vision of Child Health
• Knowledge of Reproductive and Developmental Toxicology
• Policy Approach within an ethical framework• Social responsibilities• No technical solutions• Restriction of freedoms• Precautionary Principle
Convergence of Issues
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
WHO Vision for Child Health
A World Fit for Children • Promoting healthy lives• Providing quality education• Protecting against abuse,
exploitation and violence• Combating HIV/AIDS.
http://www.unicef.org/why/why_worldgoals.html
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
CDC Vision for Child Health
“Environmental Health at CDC strives to promote health and quality of life by preventing or controlling those diseases or deaths that result from interactions between people and their environment.”
http://www.cdc.gov/node.do?id=0900f3ec8000e044
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
American Academy of Pediatrics
Mission and vision
To attain optimal physical, mental and social health and well-being for all infants, children, adolescents and young adults.
http://www.aap.org/member/memcore.htm
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
American Academy of Pediatrics
The APA goes on to state: “To this purpose, the AAP and its members dedicate their efforts and resources.
The vision: 1) to advocate for infants, children, adolescents, and young adults and provide for their care; 2) to collaborate with others to assure child health; and ….
http://www.aap.org/member/memcore.htm
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
“Children can develop and mature in an
environment that allows them to reach and maintain their full
potential.”
Vision for Child Health
Steven G. Gilbert, 1999
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
“Conditions that ensure that all living things have the best opportunity to reach and maintain their full genetic potential.” Steven G. Gilbert, 1999
Human & Environmental Health
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Are we ??
Are we adequately protecting our children and wild life by preventing exposures to harmful agents?
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
So Many Chemicals so Little Data
2863 above 1 Million pounds
78.2% no data
21.4% some data
12 or 0.4% good data
www.preventingharm.org
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
"All scientific work is incomplete - whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have or postpone the action that it appears to demand at a given time. "
Sir Austin Bradford Hill (1965)
Sir Austin Bradford Hill
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
1. Strength of association
2. Consistency of findings
3. Biological gradient
4. Temporal sequence
5. Biologic or theoretical plausibility
6. Coherence with established knowledge
7. Specificity of association
Sir Austin Bradford Hill (1965)
Determining Causation
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
ELSI
Ethical Legal / Regulatory Social Implications or Issues What is unsaid or missing? Science Values Politics
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Socially responsible white guys?
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Doubt / Uncertainty
"Doubt is our product since it is the best means of competing with the 'body of fact' that exists in the mind of the general public.“
1969 an executive at Brown & Williamson owned by R. J. Reynolds Tobacco Company
(Doubt Is Their Product by David Michaels in Scientific American, June 15, 2005)
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
David Michaels
“Doubt is their product – How Industry’s Assault on Science Threatens Your Health”
2008 - Oxford
Tobacco, Chromium 6, second hand smoke ….
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
"A thing is right when it tends to preserve the integrity, stability, and beauty of the biotic community. It is wrong when it tends otherwise." -
Aldo Leopold, 1949, A Sand County Almanac
The First Bioethicist
---------- 1887 - 1948 ----------
Aldo Leopold
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
“An ethic, ecologically, is a limitation on freedom of action in the struggle for
existence”Aldo Leopold
Limits on Freedom
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
“The Commons”
The Tragedy of the CommonsBy Garrett Hardin, Science, 1968
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Technical Solutions
“It is our considered professional judgment that
this dilemma has no technical solution.”
The Tragedy of the CommonsBy Garrett Hardin, Science, 1968
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Problems – Solutions?
Lead and kids Fetal alcohol syndrome Nuclear disarmament Bioterrorism Ocean Fisheries Persistent chemicals The Commons
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Ethics
NOT about Morals
Ethics are a generalized conceptual frame work
for decision making.
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Morals
Morals are an individual frame work for decision making that
includes personal values.
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Biomedical Ethics
• Respect for Autonomy• Nonmaleficence
• Beneficence• Justice
Beauchamp and Childress, 1994
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Respect for Autonomy
• B&C – a norm of respecting the decision making capacities of autonomous persons– Support decisions of clients– No right or wrong– Optimal use of information– Education– Honesty – tell the facts– (not truth, not right or wrong)
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Non-maleficence
• B&C – a norm of avoiding the causation of harm– Do no harm (the Hippocratic Oath)
– Truth telling to avoid harm
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Beneficence
• B&C – a group of norms for providing benefits and balancing benefits against risks and cost– Do good
– Golden rule of Christian tradition – do unto others
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Justice
• B&C – a group of norms for distributing benefits, risks and cost fairly– Equal Access
– Right to medical care
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
“When an activity raises threats of harm to human health or the environment,
precautionary measures should be take even if some cause and effect relationships are not
fully established scientifically.”
Wingspread Conference, 1998.
Precautionary Principle
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
FDA regulations of Drugs (1938) FDA regulations of Dietary
Supplements (Dietary Supplement Health and Education Act of 1994 (DSHEA))
Ephedra present an unreasonable risk of illness or injury (Dec, 2003)
Safety & Efficacy vs Harm
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
• Setting goals (Health indicators)• Taking preventive action in the face of
uncertainty• Shifting the burden of responsibility to the
proponents of an activity (Who benefits?)• Exploring a wide range of alternatives to
possibly harmful actions (Is it necessary?)• Increasing public participation in decision
making (transparency of information & environmental justice)
Central components
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
1) Respect - for the needs and rights of this and future generations as well as others who cannot speak for themselves
2) Humility - towards the natural world and our ability to understand it through science
3) Democracy - giving people a voice in matters that affect their lives
4) Responsibility - government’s public trust responsibility to manage the commonwealth for this and future generations.
- Individuals’ including industry, obligation to take responsibility for their actions in the world.
Values of the precautionary principle
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Guiyu, China 2001 Guiyu, China 2001
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Accra, Ghana 2007Accra, Ghana 2007
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Available from: www.ban.org
The Digital Dump:
Exporting Re-use and Abuse to Africa
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Basel Basel ConventioConventionn
Adopted Adopted March March 19891989
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Basel Convention and Ban stand as Landmark Agreements for Cost Internalization and Environmental Justice
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Basel Ban
Adopted March 1995
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Basel Convention on the Control of Transboundary Movements of
Hazardous Waste and their Disposal
March 1989, to 118 nations signingTo date, 170 countries have ratified
the treaty.Not ratified by United States
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Conclusion
• We have the knowledge• We recognize our ethical
responsibility• We can be thoughtful public
health advocates• Its time for action to protect child
health
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
The Potential of Children
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Ethics and the Precautionary Principle
Questions or Comments?
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
Additional Information
The Science and Environmental Health Network (SEHN) (www.sehn.org)
Late lessons from early warnings: the precautionary principle 1896-2000 – European Environment Agency (free)
(http://reports.eea.eu.int/environmental_issue_report_2001_22/en)
Garrett Hardin - The Tragedy of the Commons (Science, 1968)
Ethics and Environmental Health – Mini Monograph - Environmental Health Perspectives (November 2003)
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
1860’s - Scientific method in medicine, Gregor Mendel
1928 - Penicillin discovered – widely used WWII
1920’s - Lead in gasoline, lead in paint
1931 - 30 states had sterilization laws on books
1932 - Tuskegee syphilis study initiated
1947 - Nuremberg - The Doctors Trial
1952 - First open heart surgery & Chlorpromazine
1953 - Structure of DNA – Watson & Crick
Ethics and Science
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
60’s - Thalidomide, mercury, chronic hemodialysis, amniocentesis, informed consent, IRB’s
70’s - Hastings Center founded, bioethics defined, Tuskegee noticed, Belmont Report (3 principles), Genentech Inc. founded, awareness of FAS, sensitivity of developing CNS
80’s - Recombinant microorganism could be patented, lead is harmful to developing brain
90’s - molecular biology, sequencing of human genome (other species), Jurassic Park
00’s - US stem cell research restricted
03 - Human cloned?
Ethics and Science
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Ethics & Prec Prin 10/31/08 A Small Dose of Toxicology
• Children have a right to a safe, fair and healthy environment
• Ethical Responsibility to share and use of knowledge
• Duty to promote health and well being of children
• Thoughtful public health advocate
Knowledge - Responsibility