ETPGAH UK Mirror Group

Progress report

Phil Sketchley - Chief ExecutiveNational Office of Animal Health Ltd

UK Mirror Group

> Structure and functioning (stakeholders, chair, secretariat, meetings, etc.)

> Action plan and selection of priorities

> Communication at national level

> Directing national funding

> Work programme for 2008

Structure of UK Mirror Group> Secretariat: VMD (Veterinary Medicines Directorate)

– Professor Steve Dean – Chief Executive– Dr Jack Kay – VMD-R&D and Science Policy Manager– Gemma Adams – secretary

> Chair: Phil Sketchley - NOAH – National Office of Animal Health – representing UK animal medicines industry.

> Current stakeholders:– Professor Quintin McKellar - Dean RVC- Royal Vet College– Professor Julie FitzPatrick - Chief Executive, Moredun Research

Institute.– Dr John Preston MRCVS – VMD Board.– Catherine McLaughlin – Animal Health and Welfare, National

Farmers Union,– Dr Alex Morrow – Defra Animal Health and Welfare and Eurogap.– Professor Jim Scudamore – Liverpool Vet School & ETPGAH

consultant.– Invitation to CVO (vacant)

Progress of UK Mirror Group

> 2 meetings held so far –hosted by Defra> July 2007 and Jan 2008

> Key Actions @ first meeting:ESTABLISHING GAPS in Research

> To assist in developing a common priority list, it was agreed each member would submit details of their perceived priorities:

– 7 most important exotic diseases– 7 most important endemic diseases– 7 most important zoonotic diseases– 7 most important products for treatment– 7 most important areas for further research

Exotic Diseases Priorities

> Avian influenza

> Foot and Mouth

> Blue tongue disease

> Newcastle disease

> Veterinary Laboratories Agency;

> Institute for Animal Health, Compton; Centre for Infections,

> Health Protection Agency

> Institute for Animal Health, Pirbright

> Institute for Animal Health, Pirbright

> Veterinary Laboratories Agency;

> Scottish Agricultural College

Disease UK groups with expertiseDisease UK groups with expertise

Endemic Diseases Priorities

> Mastitis (multi-agent)

> Tuberculosis (and diagnostic tuberculins)

> Parasitic gastroenteritis

> Lameness

> University of Bristol;

> Veterinary Laboratories Agency, Moredun, > AFBI Stormont,> Imperial College; > Institute for Animal Health, Compton

> Moredun Research Institute

> University of Bristol;> Royal Veterinary College; > University of Liverpool;> Scottish Agricultural College; > University of Bristol

Disease UK groups with expertiseDisease UK groups with expertise

Zoonotic Disease Priorities

> VTEC 0157

> Campylobacter

> Salmonella

> Antimicrobial resistance

> Veterinary Laboratories Agency;> Health Protection Agency; > University of Edinburgh; > Imperial College

> Veterinary Laboratories Agency, > Institute for Animal Health, Compton; > University of Bristol;> University of Cambridge;> University of Nottingham; University of Oxford

> Veterinary Laboratories Agency, > Institute for Animal Health, Compton; > Institute of Food Research, Norwich; > University of Bristol; > University of Cambridge; > University of Nottingham

> Veterinary Laboratories Agency; > University of Birmingham; > Health Protection Agency; > University of Bristol; > Royal Veterinary College

Disease UK groups with expertiseDisease UK groups with expertise

SummaryDisease type Disease UK groups with expertise Exotic Avian influenza Veterinary Laboratories Agency; Institute for Animal Health,

Compton; Centre for Infections, Health Protection Agency Foot and mouth Institute for Animal Health, Pirbright Blue tongue disease Institute for Animal Health, Pirbright Newcastle disease Veterinary Laboratories Agency; Scottish Agricultural College Endemic Mastitis (multi-agent) University of Bristol; Tuberculosis (and diagnostic tuberculins) Veterinary Laboratories Agency, Moredun, AFBI Stormont,

Imperial College; Institute for Animal Health, Compton Parasitic gastroenteritis Moredun Research Institute Lameness University of Bristol; Royal Veterinary College; University of

Liverpool; Scottish Agricultural College; University of Bristol Zoonotic VTEC 0157 Veterinary Laboratories Agency; Health Protection Agency;

University of Edinburgh; Imperial College Campylobacter Veterinary Laboratories Agency, Institute for Animal Health,

Compton; University of Bristol; University of Cambridge; University of Nottingham; University of Oxford

Salmonella Veterinary Laboratories Agency, Institute for Animal Health, Compton; Institute of Food Research, Norwich; University of Bristol; University of Cambridge; University of Nottingham

Antimicrobial resistance Veterinary Laboratories Agency; University of Birmingham; Health Protection Agency; University of Bristol; Royal Veterinary College

Others?> West Nile Fever> Echinococcus

multilocularis> Classical swine fever> African Horse Sickness> Leishmaniasis (via

PETS)> Heartworm (dirofilaria

immitis)> Fascioloiasis> Anthrax> Cryptosporidiosis> Toxoplasmosis> Leptospirosis

> Toxoplasmosis> Sheep scab> African Swine Fever> Bovine viral diarrhoea> Porcine reproductive

and respiratory syndrome

> Tick-borne diseases> Necrotic enteritis> Infectious bronchitis> Gumboro & Mareks> Brachyspira> Neospora

> Cat Flu (emerging virulent strains and novel approaches to control)

> Border’s disease

> Strangles

> Feline Immunodeficiency Virus

> Mycoplasma

> Feline Infectious Peritonitis

> Myxomatosis

> Angiostrongylus vasorum

> E. Cuniculli

> Pasterellosis (rabbits)

> Rabies

> Nosema ceranae infestation

> Equine protozoal myeloencephalitis

> Porcine Multisystemic Wasting disease (PMWS) pigs

> Transmissable Spongiform Encephalopathies

> Caseous Lymphadenitis (sheep)

> Clostridium botulinum

ANNEX: ADDITIONAL DISEASES AND ISSUES OF IMPORTANCE TO UK TO BE KEPT UNDER REVIEW

> Infectious pancreatic disease (IPN) salmon

> Bovine abortion

> Bovine respiratory disease

> Swine respiratory disease

> Poultry coccidiosis/ colisepticaemia

> Varroa destructor infestation

> Digitial Dermatitis

> Neopspora vaccine

> Anthelmintic resistance (sheep mainly)

> Caseous Lymphadenitis (sheep)

> RabiesOrf/ringworm

> Listeriosis

> Lyme Borreliosis

> Blackhead (turkeys)

> Bee products – Small Hive Beetle, etc.

> Anticancer medicines for companion animals

> Antibiotic to treat nosema (both apis and ceranae forms)

> Fish infectious diseases and issues (e.g. ERM, PKD, sea lice)

ANNEX: ADDITIONAL DISEASES AND ISSUES OF IMPORTANCE TO UK TO BE KEPT UNDER REVIEW

ANNEX: ADDITIONAL DISEASES AND ISSUES OF IMPORTANCE TO UK TO BE KEPT UNDER REVIEW

> Anthelmintics (new mode of action chemical family and vaccines)

> Alternatives to animal challenge tests for vaccines> DIVA vaccines> Risk based methodology for re-testing veterinary

vaccines> DNA vaccines> Coccidiosis> Chlamydiosis> Equine viruses> Brucellosis> Ruminant respiratory viruses> TSEs

Centres of expertise for collaboration with UK Mirror Group-summary

> Institute for Animal Health (Pirbright) - FMD, Bluetongue

> Institute for Animal Health (Compton) - Salmonella, Campylobacter, Mareks Disease, Coccidiosis

> VLA (veterinary Laboratories Agency) - TB, Rabies, AI

> Moredun - Parasitic gastroenteritis, Chlamydiosis, ParaTB

> University of Bristol - Campylobacter, Salmonella

> University of Cambridge - Salmonella, Campylobacter

> RVC - influenza (epi), Lameness, Antimicrobial resistance.

> AHT (Animal Health Trust) - equine viruses

> Stormont - Brucellosis, ruminant respiratory viruses

Communication at national level

> So far just within immediate group

> Now we intend to embrace a larger audience of research establishments

Directing national funding

> No specific actions initiated yet.

> This will be addressed at our next meeting in April

> Also to determine a detailed work programme after identifying collaboration with other national mirror groups