evaluation of cbc
DESCRIPTION
Evaluation of CBC. Evaluate type of WBCs Reticulocyte count RBC size, shape, color MCV: size RBC color (hypo or normo -chromic) Mean corpuscular hemoglobin concentration (MCHC) Mean corpuscular hemoglobin (MCH). Other labs. PT, PTT (APTT) Bleeding time Platelet agglutination. - PowerPoint PPT PresentationTRANSCRIPT
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Evaluation of CBC
• Evaluate type of WBCs• Reticulocyte count• RBC size, shape, color– MCV: size– RBC color (hypo or normo-chromic)• Mean corpuscular hemoglobin
concentration (MCHC)• Mean corpuscular hemoglobin
(MCH)
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Other labs
• PT, PTT (APTT)• Bleeding time• Platelet agglutination
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Hematopoiesis
• Liver– Blood clotting factors– Vit K
• Bone marrow – Major hematopoietic organ– Erythropoitin secreted by kidneys
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Spleen
• Immunologic function until age 5• Stores platelets• Destroys aged RBC’s• Filters blood
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Nutritional requirements for erythropoiesis
• Protein• Vit B12
• Folic acid• Vitamin B6• Vitamin C• Iron
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Iron
• Iron necessary synthesis of Hgb• Hgb carries oxygen to tissues• Iron absorbed from small intestine• Binds with transferrin for transport• 30% stored as ferritin
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AnemiaAnemia: a reduction of RBCs and/or Hgb
concentration from age norm.Causes• Excess loss of blood• Excess RBC destruction• Insufficient RBC production• Morphology problem (size, shape, color of
RBCs)
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Clinical Manifestations: Anemia• Pallor• Tachycardia• Fatigue/lethargy• Muscle weakness• Irritability • Decreased pulses/cap refill
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Iron Deficiency Anemia• Anemia d/t lack of adequate iron to meet
needs for Hgb formationDiagnostic labs:• CBC– Hgb, Hct, retic count
• Serum iron• TIBC (total iron binding capacity)• Serum ferritin
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Consequences of IDA
• More susceptible to infection• Developmental & behavioral delays• Lifetime behavior & learning problems• Increases lead absorption
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Causes of Iron Deficiency
• Insufficient intake or blood loss• Neonatal stores of iron • Premature infants• Cow’s milk• Adolescent growth spurt• Female puberty
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Health Promotion• Prenatal nutrition• Iron fortified formula• Iron fortified foods after 6 mo• Limit cows milk• Screening • Iron supplements• Foods rich in iron (“Parents Want to Know”)
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Proper administration of iron supplements
• Dosage based on elemental iron• Empty stomach w/fruit juice– Vit C helps w/absorption– Take with straw
• Calcium binds w/iron• Teach about side effects• Safe storage
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Nursing Diagnoses IDA
• Knowledge deficit• Activity intolerance• Altered nutrition: < body requirements• High risk for altered growth & development
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Leadthe problem:– Competes for iron-binding sites– Cellular injury all organs– Children absorb more readily
Symptoms of lead poisoning:– Non-specific– Behavior & learning problems– Slowed growth– Hearing problems– Headaches– Anemia
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Lead Poisoning: sources
• Lead based paint• Soil, water pipes • Pottery (improper glaze)• Parent’s clothes• Traditional medicines• Toddlers & preschoolers more at risk
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Lead Poisoning:• Primary Prevention– Education– Screening– Hand washing– Foods high in iron, calcium & Vit C– Damp mop– Clean toys/pacifier – soapy water
• secondary prevention– Chelation
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Sickle Cell Disease-Intro
• Hereditary hemoglobinopathies• Normal Hgb replaced by sickle-shaped Hgb S• Neonates: Hgb F
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General Clinical Manifestations
• Possible growth retardation• Chronic anemia• Possible delayed puberty• Susceptibility to sepsis• Pain: acute & chronic
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Complications of Sickle Cell Disease
• Vasoocclusive crisis– Painful episode– Acute chest syndrome– Dactylitis (hand-and-foot syndrome)– Priapism (persistent erection of the penis)– Cerebrovascular accident
• Acute sequestration crisis• Aplastic crisis
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Triggers: Vaso-occlusive Crisis• Hypoxia• Dehydration• Infection• Stress - physiological & emotional• Cold
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Therapeutic Management:Vaso-occlusive Crisis
• Fluids (hydration)• Analgesics ATC• Heat to painful site• Oxygen – prn• Rest• Blood transfusions• Emotional support
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Therapeutic Management SCD
• Prevent crisis• Splenectomy• Hydroxyurea• Others under investigation– Nitrous oxide– Stem cell transplant
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Nursing Diagnoses
• Risk for infection• Impaired physical mobility• Altered family process• Pain• Altered tissue perfusion• Knowledge deficit
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Hemophilia – Intro• Coagulation deficiency factor VIII, IX, XI• Hereditary; X-linked recessive• Group of disorders– hemophilia A most common– Factor VIII deficiency
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Diagnosis
• History, presenting sx, lab• Lab– Prolonged PTT– Decreased Factor VIII or IX– Normal PT, thrombin time, fibrinogen, & platelet
count.
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Nursing Diagnoses
• Risk for Injury (internal)• Pain• Impaired physical mobility• Knowledge deficit
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Risk for Injury (internal)
Outcome:Interventions:• No rectal temps• Injury protection with activities• Any head injury: check for SDH• Administer necessary factor• Transfuse – whole blood or FFP• DDAVP (desmopressin acetate)
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Therapeutic Intervention: Deficient Knowledge
Outcome: • Medic Alert bracelet • Injury prevention appropriate for age• CMs of internal bleeding• Soft toothbrush; regular checkups• Avoid meds w/ASA• Med administration & storage
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Common Problem: Hemarthrosis
Clinical Manifestations
• Impaired ROM• Pain• Swelling
Treatment• Immobilization• Elevation• Ice• Appropriate clotting
factor• Control pain• Maintain Mobility
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Overview of Childhood Cancers• 1% of all cancers; 2nd leading cause of
childhood deaths (McKinney)
• Leukemia, Brain & spinal tumors, lymphoma – most common
• Treatment challenge:– Minimize treatment-related side effects– Maintain normal growth & development
• Fight for palliative care and hospice when indicated.
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Cardinal Signs and Symptoms of Cancer in Children
• Overt signs– A mass– Purpura– Pallor– Weight loss– Whitish reflex in the eye– Vomiting in early morning – Recurrent or persistent fever
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Cardinal Signs and Symptoms of Cancer in Children (cont’d)
• Signs and symptoms that may be covert– Bone pain– Headache – Persistent lymphadenopathy– Change in balance, gait, or personality– Fatigue, malaise
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Neuroblastoma
• Originate from neural crest cells• Can be present wherever sympathetic
nervous tissue is found• Exclusively in infants & children• Usually in abdomen• Infringes on adjacent normal tissue & organs
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Treatment
• No metastasis: surgical excision• Later stages:– Tumor debulking– Chemo &/or radiation– Surgery if chemo/radiation reduces tumor size– Stem cell transplant
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Brain tumor
• most common solid tumor in children• present w/signs increased ICP• Tx: surgery, chemo, radiation
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