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Naturalskin care

PsoriodermWWW.PSORIODERM.COM

EDITED BY: DR. GYÖNGYIKE BELEZNAY - DR. ZOLTÁN NAGY

Monograph of

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26PSORIODERM

PRODUCT LINE

Psoriasis is a chronic, immune-mediated dis-order that results from a polygenic predispo-sition combined with environmental triggers, e.g. trauma, infections or medications.

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KNOW MORE ABOUT

THE SKIN

PSORIAIS ADULTSAND CHILDHOOD

PSYCHOLOGICAL SYMPTOMS

The outer covering of human body is the skin, which is com-posed of three main layers: epidermis, der-mis and subcutaneous tissue.

The touch, the caress are important part of human relationships, and of emotional expressions. Wheth-er mother–child or male-female relation-ship.

The members of the Psorioderm product line are good for care about the psoriasis, eczema, skin showing signs of seborrhoea; and for the highly dan-druff, psoriasis, sebor-rhoea, itchy, sensitive scalp daily care.

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68POST MARKETING

SURVAY

NATURALINGREDIENTS

CLINICAL STUDY

PSORIODERM SENSITIVE

PRODUCT LINE

359 Dermatologist and Pharmacist’s opinion was collected from Hungary, Slovakia and Romania (2010 - 2011) by continuous routine application of Psorioderm® products in subjects with mild to moderate plaque psori-asis and atopic dermati-tis (AD) disease.

Natural ingedients, of Psorioderm, and Psorioderm Sensitive.

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The Hungarian Quality Product Award honored, paraben- and salicylic acid-free Psorioderm® Sensitive Product Line is good for eczema, atopic, psoriasis and seborrheic skin for dai-ly care, even under the age of 3. They contain jojoba and honey ex-tracts, contents of Shea butter plus vitamin E.

Overall, daily used Psorioderm® cream can alleviate the psoriatic symptoms. Consequent-ly, Psorioderm® cream may reduce the require-ments (application fre-quency) therefore the side effects of topical steroids, which are the most commonly used topical agents in psoria-sis.

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BRIEFLY ABOUT PSORIASISThe psoriasis from the chronic skin diseases are the most prevalent and non-commu-nicable, which produces a variety of changes in the appearance on the skin, nails and very rare on mucous membrane. It is chronic, long-term and recurrence prone disease. Psoriasis is a genetic taint with increased skin production and chronic inflammation, what appears because of some external or internal influences. At the same time, psoriasis is not only the skin disease, as it is an immune system disorder, it effects the whole body. To the serious skin problems may associate serious symptoms , reduced mobility caused due to small joint gout and the inflammation. Those psoriasis spots which disfigure the skin; they cause also not just unpleasant ithc-ing, but can generate soul and self acceptance problems as well Psoriasis does not threaten the life, in the same time it is one of the skin diseases what destructs so much the quality of life.

PSORIASIS

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KNOW MORE ABOUT THE SKIN:

The outer covering of human body is the skin, which is com-posed of three main layers: EPIDERMIS, DERMIS AND SUBCUTANEOUS tissue. Our skin is one of the largest and most important track, which is straight-away shown to the world. Our lifestyle, diet, mood these effect on its state. It is a continuously renewing protection, what defends you from the sun, wind, various physical and biological impact.The outer covering of human body is the skin, which is com-posed of three main layers: epidermis, dermis and subcutane-ous tissue. Our skin is one of the largest and most important track, which is straight-away shown to the world. Our life-style, diet, mood these effect on its state. It is a continuously renewing protection, what defends you from the sun, wind, various physical and biological impact.

The skin epidermis is thin, transparent, multi-segmented horny layer what is continuously regenerated. The lowest layer of the epidermis is composed by a 1-2 microns sized thin cell line, this part ensures the constant supply of the new cells. The lowest, fissiparous and youngest cells are located in the malpighian layer, through they can take their nutrients. The nutrient uptake goes through the tiny blood vessels in the dermis. The cells divide at the malpighian layer continu-ously, then they come off and the new ones press them to the body surface. These epithelial cells need 28 days to reach from the bottom layer to the top layer of the epidermis. The thickness of the horny cell layer (stratum corneum) is different on everybody zones, in the bends are the thinnest. Usually 20 cell lines are 50-200 microns sized. On the sole it is the thickest, can be in up to 1 mm or in case of the calluses it can be either 2 mm. On the sedimentary rock top layer of the epidermis the cells are totally hard, dead, and constantly wear, slough. In other words, the stratum corneum layer is used the most compare with the other layers of epidermis

The next layer of the skin is the dermis. A 60 kg adult human has approx. 3-4 kg dermis. The high tensile strength collagen and elastic protein called elastin make the skin re-sistant and flexible, and available for physical activity. You can find the papillary region is composed of loose areolar connective tissue. This is named for its finger-like projec-tions called papillae, it extends toward the epidermis. The papillae provides the dermis with a „bumpy” surface that interdigitates with the epidermis, strengthening the connec-tion between the two layers of skin. On the hand skin the swells are clearly visible, they make the fingerprints. The main tasks of the dermis: mechanical protection, the regu-lation of immune system and the salt-water balance of the body. In the dermis you can find the hair follicles and the and sebaceous glands, what supply the skin. If the damage reaches the dermis, it causes irreversible clues, heals with scars.

STRUCTURE OF A NORMAL SKIN

OUR SKIN IS VALUABLE – NO MATTER HOW OLD WE ARE

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The main tasks of the subcutaneous tissue, what is the bottom insulation of the skin, are: the regulation of energy production and taking off the edge for the mechanical effects. The subcu-taneous tissue is connected to the dermis above with relatively large connective tissue fibers, below is bounded by the muscle fibers. In the loose connective tissue layer you can find the fat cells, they are from big fat droplets. They compose the cellulite as round units. This layer is mainly composed of fatty tissues; it is the power warehouse of the body, what can be used if it is necessary. During the weight loss this fat disappears first. If it is damaged, it can heal with scars.

Except the palms and soles the almost entire surface of the skin is covered by hair. It is responsible for the protection. The hair colour depends on the presence of melanin pigment . The hair is composed from keratin, or alias from horn, it has root deep in the dermis. The blood vessels and the nerves run into the hair follicle, to the bottom of the root. The hair does not just grow, but also is replaced, a healthy person lose daily 50-60 hair, then instead of them new grow.

The nail grows out from the crease of the dermis and from the nail matrix. The lower part of the nail fits to the nail bed, what is situated on the terminal phalanx. The vital part of the nail, what continuously grows, is the root and has slightly bright half-moon shaped area. The name of it is lunala and can be found at the base of the nail, you can see when the skin does not grow on it. You can find several kinds of sebaceous gland and sweat-gland in the skin. The sebaceous glands from the dermis have the same exit with hair follicles. These glands product oily material, tallow what protects the skin and make it flexible, these productions grease the hair in the main time the hair grows slowly and supply the lubricant to the surface of the skin. From there we disperse that with the hands, by body movements and by combing. The tallow is composed from wax, fatty acid, cholesterol, and mixtures of residues of dead cells. There are 2-4 million sweat glands in the dermis, they produce a completely different fluids. Their responsibil-ities are the selection of the toxins and cooling by evapora-tion. During the really warm days they can evaporate several litres of fluids by keeping the surface of the body moist.

PSORIASIS adult and childhood

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ABOUT

PSORIASISNot deadly

Not infectiousNot be cured

PSORIASIS, SEBORRHEIC DERMATITIS, PITYRIASIS

ROSEA, AND LICHEN PLANUS ARE DISEASES THAT

PRESENT WITH PAPULOSQUAMOUS LESIONS (scaly

papules and plaques). Although these diseases may have a

similar morphology, their underlying etiologies vary. Sec-

ondary syphilis, cutaneous T-cell lymphomas, and con-

nective tissue disease may also present with papulosqua-

mous lesions and should be included in the differential

diagnosis.

KEY FEATURES:

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic pre-disposition combined with environmental triggers, e.g. trauma, infections or medi-cations. The underlying pathophysiology involves T cells and their interactions with dendritic cells and cells involved in innate immunity, including keratinocytes. Identi-fication of susceptibility genes has pointed to a major role for both the innate and the adaptive immune systems. Sharply demar-cated, scaly, erythematous plaques chrater-ize the most common form of psoriasis; oc-casionally, sterile pustules are seen. The most common sites of involvement are the scalp, elbows and knees, followed by the nails, hands, feet and trunk (including the interglu-teal fold) Typical histologic findings include acanthosis with elongated rete ridges, hypogranulosis, hyper- and parakerato-sis, dilated blood vessels and a perivascular infiltrate of lym-phocytes with neutrophils singly or within aggregates in the epidermis. Psoriatic arthritis is the major associated systemic manifestation and the most common presentation is asym-metric oligoarthritis of the small joints of the hands and feet; other comorbidities include cardiovascular disease in patients with moderate to severe disease. Phototherapy, methotrexate, cyclosporine and “biologic” therapies that target key immune effector cells and cytokines lead tosignificant clinical im-provement.

INTRODUCTION:

Psoriasis is an immune-mediated polygenic skin disorder. Various environmental triggering factors, e.g. trauma, infe tions or medications, may elicit disease in predisposed indi-viduals (1). The characteristic lesion is a sharply demarcated erythematous plaque with micaceous scale, and the plaques may be localized or widespread in distribution. Histological-ly, hyperkeratosis, parakeratosis, acanthosis of the epidermis,

tortuous and dilated vessels, and an inflammatory infiltrate composed primarily of lymphocytes are observed.Psoriasis is a systemic disease process in which up to 20 - 30% of the patients have or will develop psoriatic arthritis. In addition, in patients with moderate to severe psoriasis, there is an increased relative risk for metabolic syndrome and atherosclerotic cardiovascular disease. Psoriasis also has a si nificant impact on patients’ quality of life (2), and in surveys, patients feel that the current treatments, although often effec-tive, do not provide a satisfactory long-term solution.

EPIDEMIOLOGY AND GENETICS:

In most reviews, the prevalence of psoriasis is said to be 2% of the world’s population. However, in the US and Canada, prevalences as high as 4.6% and 4.7% have been reported, respectively. This contrasts with frequencies in Africans, Af-rican-Americans, Norwegian Lapps, and Asians of between 0.4% and 0.7% (2). Brandrup and Green (3) reported that two-thirds of affected individuals were suffering from mild psoriasis, while one-third had more severe involvement. In one large group of patients with psoriasis (n = 1728), 79% had nail changes (4). Psoriatic arthritis has been found to af-fect 5–30% of patients with cutaneous psoriasis in different series (2).

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Psoriasis can first appear at any age, from infancy to the eighth decade of life. Two peaks in age of onset have been reported: one at 20–30 years of age and a second peak at 50–60 years. In approximately 75% of patients, the onset is before the age of 40 years5–7, and in 35–50%, it is before the age of 20 years. Although the age of onset is earlier in women than in men, the natural history is similar – chronic with intermittent remissions. In one epidemiologic study, 39% of the patients stated they had experienced remissions of 1–54 years (7).In Europe, the overall prevalence rate for juvenile psoriasis was found to be ~0.7% (8,9,) with an increase from 0.37–0.55% in those 0 to 9 years of age to 1.01–1.37% in those 10-19 years of age (8–10). Plaque psoriasis is the most frequent form of the disease in children, followed by guttate psoriasis (11).

GENETIC FACTORS

Depending upon the series, a positive family history has been reported by 35% to 90% of patients with psoriasis. Based on a large survey-based study in Germany, if both parents had psoriasis, the risk of their child developing psoriasis was 41%, whereas if only one parent were affected, the risk was 14%; the risk was 6% if just one sibling had psoriasis (12). Analysis of concordance rates among monozygotic and diz gotic twins is another method for examining the influence of genetic factors on a disease. Farber and Nall (13) reviewed the published data from twin pair studies in psoriasis. Of 141 monozygotic twin pairs, 82 were concordant for psoriasis and 59 were discordant; of 155 dizygotic twin pairs, only 31 were concordant and 124 were discordant for psoriasis.Thus, there is a two- to threefold increased risk of psoriasis in monozygotic twins as compared to dizygotic twins (7), im-plying that genetic factors are important. The distribution of the lesions, the severity, and the age of onset were similar in the monozygotic twin pairs, whereas these features differed in the dizygotic twin pairs. This observation suggested that genetic factors also play a role in the clinical course of pso-riasis.

HLA STUDIES

Histocompatibility antigens (HLA) are surface antigens on h man cells, and the corresponding chromosomal region is called the major histocompatibility complex (MHC). It is situated on the short arm (p) of chromosome 6. Psoriasis is associated with HLA-Cw6, with the presence of HLA-Cw6 conferring a relative risk of 13 for developing psoriasis in the Caucasian population and 25 in the Japanese. HLA-Cw6 is strongly linked to the age of onset of psoriasis. In one series, HLA-Cw6 was expressed in 90% of the patients with early-onset psoriasis, in 50% of those with late-onset psoriasis, and only in 7% of a control population.

A specific MHC class II antigen (DRB1*0701/2) also appeared to be associated with early-onset psoriasis, and the psoriasis-as-sociated HLA alleles were often in an extended haplotype: Cw6-B57-DRB1*0701-DQA1*0201-DQB1*030314. Individuals carrying this haplotype were found to have a 26-fold increased risk of developing early-onset psoriasis. As a result, some clinicians have designated patients with early-onset pso-riasis, a positive family history of psoriasis, and expression of HLA-Cw6 as having type I psoriasis and those with late-onset disease, no family history, and a lack of expression of HLA-Cw6 as having type II psoriasis15. Other HLA alleles may be associ-ated with different psoriasis variants and related conditions. For example, the HLA-B27 allele is a marker for sacroiliitis-associ-ated psoriasis and reactive arthritis.

GENOME-WIDE ASSOCIATION STUDIES

Classic genome-wide linkage analysis has identified at least nine psoriasis susceptibility regions (PSORS1–9) in different chromosomal locations (16). By far the most important genet-ic region is PSORS1 (on chromosome 6p), which is estimated to account for up to 50% of psoriasis risk. PSORS1 contains genes such as HLA-C (with the HLACw6 risk allele; see above) and corneodesmosin (CDSN). Due to high linkage disequilib-rium in PSORS1 (i.e. genes within this region are inherited as a block), it has been challenging to determine which gene(s) within PSORS1 contribute to psoriasis pathogenesis. Use of genomewide association studies (GWAS) has recently provided new insights into the genetic basis of psoriasis. In GWAS, hun-dreds of thousands of single nucleotide polymorphisms (SNPs) across the entire human genome are examined in thousands of patients (17) (see Ch. 54). Several conclusions regarding the ge-netic fa tors in psoriasis can be drawn from recent GWAS18, (19). First, most of the genes that have been implicated have immune-related functions, underscoring the importance of the innate and adaptive immune systems in the pathogenesis of pso-riasis; in contrast, relatively few genes that encode skin-specific proteins have been associated with psoriasis. Second, thus far surprisingly few interactions among the genetic variants have been identified (with the exception of HLA-Cw6 and ERAP-1; see below). Third, associated genes encode proteins with roles in particular immunologic and signaling pathways, especially those involving tumor necrosis factor (TNF), NF-κB, interfer-ons (IFN) and interleukin (IL)-23/Th17 cells (see IMMUNO-PATHOGENESIS) (19,20). Lastly, the ERAP1 gene encoding an aminopeptidase involved in MHC class I antigen process-ing is only associated with psoriasis risk in individuals carrying the HLA-Cw6 risk allele, providing evidence for the role of an MHC-restricted antigen and its presentation through HLA-C in the pathogenesis of psoriasis.

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FUNCTIONAL GENOMIC STUDIES

Microarray technology has been utilized to obtain a compr hensive picture of the genes expressed in psoriatic skin (21). More than 1300 genes were found to be differentially ex-pressed when compared to normal human skin. This group of genes included known markers of psoriasis in the skin, but it also contained numerous genes not known to be expressed in the skin. These analyses confirmed the known involvement, on a genomic scale, of T cells and dendritic cells (DCs), providing evidence for sustained chronic T-cell activation and persistence in psoriatic epidermis. Microarray-based comparison between the transcriptome of lesional skin from patients with psoriasis versus atopic dermatitis have revealed not only differences in expression of genes with immune function, but also differences in genes expressed by keratino-cytes. For example, skin-derived ant microbial proteins were expressed at high levels in psoriatic skin but at low levels in skin affected by atopic dermatitis (22).

PATHOGENESIS OF PSORIASIS

Because it primarily affects the interfollicular epidermis, psoriasis was long regarded as an epidermal disease in which the biochemical or cellular defect resided within the keratinocyte. Accordingly, prior to the early 1980s (23), a number of biochemical mediators, enzymes and pathways involved in epidermal function were incriminated as being abnormal in psoriasis, including cyclic AMP, eicosanoids, protein kinase C, phospholipase C, polyamines and tran forming growth factor (TGF)-α.Although associated immunologic abnormalities were re-ported in the late 1970s (24) , a major paradigm shift oc-curred when T-cell suppressive agents such as cyclosporine were found to result in significant improvement of psoriasis (25). For the past two decades, psoriasis has been regarded as a T-cell-driven disease (25). The role of lymphocyte sub-sets as well as cytokines involved in chemotaxis, homing and activation of inflammatory cells has been extensively inves-tigated, culminating in the development of novel therapeutic approaches (25). Although some regard psoriasis as an autoimmune disease, to date no true autoantigen has been definitively identified.

IMMUNOPATHOGENESISROLE OF T CELLS AND DENDRITIC CELLS:

The association of psoriasis with particular MHC alleles, such as HLA-Cw6, and (in individuals carrying such alleles) variants in the ERAP1 gene encoding an aminopeptidase in-

volved in antigen processing strongly suggests a pathogenet-ic role for antigenpresenting cells and T cells. The presence of specific T-cell subsets within the epidermis and dermis of lesional skin is well documented. In addition, a number of compounds that affect T-cell function (e.g. by targeting the IL-2 receptor, CD2, CD11a and CD4) were found to result in clinical improvement of psoriasis (25).Another argument supporting involvement of the adaptive immune system is the disappearance or development of psoriasis following hematopoietic stem cell transplantation (26,27). In addition, analysis of lesional T cells has shown oligoclonality, indicating potential antigenspecific expansion of T-cell subpopulations, possibly triggered by exogenous microbial or viral antigens or cross-reacting autoantigens, e.g. keratins (28).In humans, several cell types have been implicated in the initiation and maintenance of psoriatic lesions. Most of the epidermal T cells are CD8+, whereas the dermal infiltrate is a mixture of CD4+ and CD8+ cells. The majority of the cells in both locations are memory T cells that express cutaneous lymphocyte antigen (CLA; the skin homing receptor) and chemokine receptors such as CCR4. Natural killer (NK) T cells represent another subset of T cells that are part of the in-nate immune system and are found in psoriatic skin lesions; they interact with CD1d on keratinocytes. The resulting pro-duction of IFN-γ could contribute to additional immune stim-ulation (32)

CYTOKINES AND CHEMOKINES

Psoriasis is considered to be a disease with prominent in-volv ment of helper T-cell subsets and their secreted cyto-kines (40). Increased amounts of Th1 cytokines (IFN-γ and IL-2) are observed, whereas levels of the anti-inflammato-ry cytokine IL-10 are reduced. Based on animal studies and measurements in lesional skin, IL-12, IL-23 and IL-15 are likely to contribute to the disease. Of note, circulating lev-els of IL-22 correlate with disease severity. It has also been proposed that there is a distinct subset of IL-22-producing helper T cells (Th22 cells) that contribute to the pathogenesis of psoriasis (42,43). The IL-17-producing T cells in psoriat-ic epidermis might have a cytotoxic phenotype, qualifying them as Tc17 cells (44). IFN-γ is released by activated T cells and NK T cells in the epidermis, and it activates members of the STAT transcription factor family, which drive the expres-sion of a large number of immune-related genes that have roles in psoriasis pathogenesis. The innate immune cytokines IL-1, IL-6 and TNF-α are upregulated in psoriatic skin. TNF-α is a particularly relevant cytokine and its importance is underscored by the therapeutic efficacy of TNF-α inhibi-tors. Chemokines are important mediators in the trafficking of leukocytes, and the increased presence of several chemok-ines and their cognate receptors in psoriatic lesions has been extensively documented

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Initiation phase Plaque progression

CCL19

CCL17CCL27

M

NKT

CCL20CXCL9–11

NO

CXCL1CXCL3CXCL5CXCL8

β-defensin 1/2S100A7/8/9

Collagen IV

ROSα-defensinCXCL8CCL20

VEGFbFGFAng

Lymphvessel

LC

N

DNARNA

IL-1βIL-6IL-12IL-17A/FIL-22IL-23IFN-αIFN-γTGF-βTNF-α

KGFEGF

FGFs

Chemerin

Fibroblasts

CollagenProteoglycans

Stressedcells

Trigger

EnvironmentImiquimod

MicroorganismsDrugs

Trauma

Genotype

HLA-CIL23R

LL37

dDC

iDCpDC

Th1Th22

Th22

Th22

Th22

Th17

Naive T

Th17

Th17

Tc1

Th1

E-selectin

DC

dDC

CLA

CXCR3

CCR4

CCR6

CCR7

CCR10

VLA-1

CD45RO

IMMUNOPATHOGENESIS OF PSORIASIS.

The occurrence of triggering environmental factors in genetically predisposed individuals, carrying susceptibility alleles of psoriasis-asso-ciated genes, results in disease development. During the initiation phase, stressed keratinocytes can release self DNA and RNA, which formcomplexes with the cathelicidin LL37 that then induce interferon-α (IFN-α) production by plasmacytoid dendritic cells (pDCs; recruited into the skin via fibroblastreleased chemerin), thereby activating dermal DCs (dDCs). Keratinocyte-derived interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) also contribute to the activation of dDCs. Activated dDCs then migrate to the skin-draining lymph nodes to present an as-yet-unknown antigen (either of self or of microbial origin) to naive T cells and (via secretion of different types of cytokines by DCs) promote their differentiation into T helper 1 (Th1), Th17 and Th22 cells. Th1 cells (expressing cutaneous lymphocyte antigen [CLA], CXC-chemokine receptor 3 [CXCR3] and CC-chemokine receptor 4 [CCR4]), Th17 cells (expressing CLA, CCR4 and CCR6) and Th22 cells (expressing CCR4 and CCR10) migrate via lymphatic and blood vessels into psoriatic dermis, attracted by the keratinocyte-de-rived chemokines CCL20, CXCL9–11 and CCL17; this ultimately leads to the formation of a psoriatic plaque. Th1 cells release IFN-γ and TNF-α, which amplify the inflammatory cascade, acting on keratinocytes and dDCs. Th17 cells secrete IL-17A and IL-17F (and also IFN-γ and IL-22), which stimulate keratinocyte proliferation and the release of β-defensin 1/2, S100A7/8/9 and the neutrophil-recruiting chemokines CXCL1, CXCL3, CXCL5 and CXCL8. Neutrophils (N) infiltrate the stratum corneum and produce reactive oxygen species (ROS) and α-defensin with antimicrobial activity, as well as CXCL8, IL-6 and CCL20. Th22 cells secrete IL-22, which induces further release of keratinocyte-derived T cell-recruiting chemokines. Moreover, inflammatory DCs (iDCs) produce IL-23, nitric oxide (NO) radi-cals and TNF-α, while natural killer T (NKT) cells release TNF-α and IFN-γ. Keratinocytes also release vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and angiopoietin (Ang), thereby promoting neoangiogenesis. Macrophage (M)-derived chemokine CCL19 promotes clustering of Th cells expressing chemokine receptor CCR7 with DC in the proximity of blood vessels, with further T-cell activation. At the dermal–epidermal junction, memory CD8+ cytotoxic T cells (Tc1) expressing very-late antigen-1 (VLA-1) bind to collagen IV, allowing entry into the epidermis and contributing to disease pathogenesis by releasing both Th1 and Th17 cytokines. Cross-talk between keratinocytes, producing TNF-α, IL-1β and transforming growth factor-β (TGF-β), and fibroblasts, which in turn release keratinocyte growth factor (KGF), epidermal growth factor (EGF) and TGF-β, and possibly Th22 cells releasing FGFs, contribute to tissue reorganization and deposition of extracellular matrix (e.g. collagen, proteoglycans). LC, Langerhans cell (Courtesy, Dr Paola DiMeglio)

INNATE IMMUNITY AND ROLE OF KERATI-NOCYTES:

In the skin, various cell types are involved in innate (non-adaptive) immune response pathways. These include DCs (myeloid DCs and pDCs), NK T cells and neutrophils, as well as epidermal keratinocytes. For example, keratino-cytes constitutively express antimicrobial proteins such as β-defensin-1 (hBD1) and secretory leukocyte protease inhib-itor (SLPI), which have direct antimicrobial activity against a broad spectrum of pathogens. In addition, keratinocytes canbe stimulated to express a wide variety of other inducible antimicrobials such as hBD2, the cathelicidin LL37, and SKALP/elafin (46). In addition to these effector molecules, keratinocytes express TLRs and secrete signaling molecules such as IL-1, IL-6, IL-8 and TNF-α. Interestingly, the antimicrobial effector protein hBD2 was also shown to have chemotactic activity via CCR6 and to bind to TLR-4. Since most of these proteins are highly expressed in lesional psoriatic skin, it is likely that they are involved in the initiation or control of the inflam-matory process; however, their precise roles remain to be determined.

Any model of the pathogenesis of psoriasis also has to account for the dramatically increased proliferation rate of keratinocytes. The cytokines and chemokines found in lesional skin are generally not mitogenic for keratinocytes. For example, IFN-γ, a prominent Th1 cytokine, is itself an-tiproliferative, but it was found to be a crucial factor in su-pernatants of lesion-derived T-cell clones that could drive keratinocyte stem cell proliferation (47).Keratinocytes within psoriatic plaques express STAT-3, sug-gesting that this transcription factor might be of pathogenetic importance. In a transgenic animal model, epidermal expres-sion of STAT-3 (in cooperation with T cells) was found to induce psoriasis-like lesions in mice (48). STAT-3 induced the upregulation of a number of genes rel-evant for psoriasis, such as those encoding ICAM-1 and TGF-α; the latter has been shown to stimulate proliferation of keratinocytes in psoriasis via an autocrine loop. As STAT-3 is activated by a variety of cytokines including IL-22 as well as IL-6, IL-20 and IFN-γ, this could represent a link between keratinocyte activation and immune cells in the developmentof the psoriatic lesion.

TRIGGER FACTORS

Triggering factors, both external (directly interacting with the skin) and systemic, can elicit psoriasis in genetically predisposed individuals. External triggering factors: The Koebner phenomenon, i.e. the elicitation of psoriatic lesions by injury to the skin, is observed in approximately 25% of patients with psoriasis. A particular patient may be “Koeb-ner-negative” at one point in time and later become “Koeb-

ner-positive”. The Koebner phenomenon suggests that psori-asis is a systemic disease that can be triggered locally in the skin. Psoriatic lesions can also be induced by other formsof cutaneous injury, e.g. sunburn, morbilliform drug erup-tion, viral exanthem. The lag time between the trauma and the appearance of skin lesions is usually 2–6 weeks.

Systemic triggering factors Infections, particularly bacte-rial infections, may induce or aggravate psoriasis. Provok-ing infections have been observed in up to 45% of psoriatic patients. Streptococcal infections, especially pharyngitis, are the most common offenders (49). Streptococci can also be isolated from other sites, e.g. dental abscesses, perianal cellulitis, impetigo. HIV infection has also been shown to aggravate psoriasis (78).Endocrine factors: Hypocalcemia has been reported to be a triggering factor for generalized pustular psoriasis. Although active vitamin D3 analogues improve psoriasis, abnormal vi-tamin D3 levels have not been shown to induce psoriasis. Pregnancy may alter disease activity, e.g. 50% of the pa-tients in one series reported improvement. However, preg-nant women may develop pustular psoriasis, also referred to as impetigo herpetiformis, sometimes in association with hypocalcemia. Psychogenic stress is a well-established sys-temic triggering factor in psoriasis (50). It has been associ-ated with initial presentations of the disease as well as flares of pre-existing psoriasis. In a prospective study, cognitive and behavioral patterns of worrying and scratching were both independently related to an increase in disease severity and pruritus 4 weeks later (51).Several drugs have been incriminated as inducers of pso-riasis, in particular lithium, IFNs, β-blockers and antimalari-als. Rapid taper of systemic corticosteroids can induce pustu-lar psoriasis as well as flares of plaque psoriasis.Obesity, increased alcohol consumption, and smoking have all been associated with psoriasis. In one analysis, smoking appeared to have a role in the onset of psoriasis, while obesity appeared to be a consequence of psoriasis(52), whereas other studies have suggested that weight gain often proceeds the development of psoriasis. Some studies have found that the prevalence of psoriasis in a population of in-dividuals who stop smoking or who lose weight eventually reverts to background levels

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CLINICAL FEATURES

Chronic plaque psoriasis, the most common variant of psoriasis vulgaris, is characterized by sharply demarcated and erythematous papulosquamous lesions. Less often, nearly all of the body surface is involved (“erythro-dermic psoriasis”) or numerous, small, widely disseminated papules and plaques are seen (“guttate psoriasis”). Occasionally, there are obvious macrosco ic pustules, as in generalized pustular psoriasis or pustulosis of the palms and soles.

From a clinical perspective, psoriasis can present with a spectrum of cutaneous mani-festations. At any one point in time, different variants may coexist in a particular individu-al, but the skin lesions all share the same im-portant hallmarks: erythema, thickening and scale. As noted in the section on Epidemi-ology and Genetics, there is also significant interindividual variability. For example, in patients with chronic plaque psoriasis, those with type I disease (HLA-Cw6+) have an earlier onset, more widespread disease and fr quent recurrences, compared to those with type II psoriasis.

Although the size of a lesion may vary from a pinpoint papule to over 20 cm in diameter, the outline of the lesion is usually circular, oval or polycyclic (the latter indi-cating that the lesion is derived from several smaller units). The configuration of psoriatic lesions due to the Koebner phenomenon reflects the etiology of the trauma. In addition to their highly characteristic sharp demarcation, psoriatic lesions are sometimes surrounded by a pale blanching ring, which is referred to as Woronoff ’s ring.The classic findings of erythema, thickening and scale are reflections of the histologic findings of elongated dilated cap-illaries that are close to the skin surface, epidermal acantho-sis plus cellular infiltrates, and abnormal keratinization, re-spectively. If the superficial silvery white scales are removed via curettage (grattage method), a characteristic coherence is observed, as if one has scratched on a wax candle (“signe de la tache de bougie”). Subsequently, a surface membrane is seen,which will also come off as a whole. If the latter is removed, then a wet surface is seen with characteristic pinpoint blee-ing. This finding, called Auspitz sign, is the clinical reflec-tion of elongated vessels in the dermal papillae together with thinning of the suprapapillary epidermis.During exacerbations, psoriatic lesions often itch. Pinpoint

papules surrounding existing psoriatic plaques indicate that the patient is in an unstable phase of the disease. In addition, expanding psoriatic lesions are characterized by an active edge with a more intense erythema. Inflamed lesions may be slightly tender. The involution of a lesion usually starts in its center, resulting in annular psoriatic lesions.

THE KEY DIAGNOSTIC CLINICAL FEATURES

The key diagnostic clinical features of psoriasis are red to pink plaques with silvery white scale on the elbows, knees, scalp, and lower back and legs. The lesions of psoriasis are distinctive. They begin as red, scaling papules that co-alesce to form round-to-oval plaques, which can easily be distinguished from the surrounding normal skin. The scale is adherent and silvery white, and reveals bleeding points when removed (Auspitz sign). Scale may become extremely dense, especially on the scalp. Scale forms but is macerated and dispersed in intertriginous areas; therefore the psoriatic plaques of skin folds appear as smooth, red plaques with a macerated surface. The most common site for an intertrig-inous plaque is the intergluteal fold; this is referred to as gluteal pinking. The deep, rich red color is another charac-teristic feature and remains constant in all areas.

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CHRONIC PLAQUE PSORIASISPsoriasis Vulgaris

Psoriasis vulgaris is the most common form of psoriasis, seen in approximately 90% of patients. Red, scaly, symmetrical-ly distributed plaques are characteristical-ly localized to the extensor aspects of the extremities, particularly the elbows and knees, along with scalp, lower lumbosa-cral, buttocks, and genital involvement.Other sites of predilection include the um-bilicus and the intergluteal cleft. The extent of involvement varies widely from patient to patient. There is constant production of large amounts of scale with little altera-tion in shape or distribution of individual plaques. Single small lesions may become confluent, forming plaques in which the borders resemble a land map (psoriasis geographica). Lesions may extend later-ally and become circinate because of the confluence of several plaques (psoriasis gyrata). Occasionally, there is partial cen-tral clearing, resulting in ring-like lesions (annular psoriasis).This is usually associated with lesional clearing and portends a good prognosis. Other clinical variants of plaque psoria-sis have been described depending on the morphology of the lesions; particularly those associated with gross hyperkerato-sis. Rupioid psoriasis refers to lesions in the shape of a cone or limpet. Ostraceous psoriasis, an in-frequently used term, refers to a ring-like, hyperkeratotic concave lesion, resembling an oyster shell. Finally, elephan-tine psoriasis is an uncommon form characterized by thickly scaling, large plaques, usually on the lower extremities. A hypopigmented ring (Woronoff ring) surrounding individ-ual psoriatic lesions may occasionally be seen and is usually associated with treatment, most commonly UV radiation ortopical corticosteroids. The pathogenesis is not well under-stood but may result from inhibition of prostaglandin syn-thesis.

In chronic plaque psoriasis, there is a relatively symmetric distributionof sharply defined, erythematous, scaly plaques the degree of body surface area involvement can vary, from limited to extensive. The scalp, elbows, knees and presacrum are sites of predilection, as are the hands and feet . The gen-

italia are involved in up to 45% of patients Plaques may persist for months to years at the same locations. Although the course of this disease is chronic, periods of complete re-mission do occur and remissions of 5 years have been report-ed in approximately 15% of patients.

Because the percentage of body surface area involved does not reflect the severity of the individual lesions with respect to erythema, induration and scaling, the Psoriasis Area and Severity Index (PASI) was formulated. This is a single score calculated from the body surface area involved (utilizing a seven-point score for involvement in each of four anatomic areas – head, upper extremities, trunk and lower extremities) and from the scores for erythema, induration and scaling(each scored using a five-point score from 0 to 4). The PASI is a cumbersome calculation and is more commonly utilized for clinical trials than for the routine management of patients with psoriasis. A score for nail involvement has also been proposed, known as the Nail Psoriasis Severity Index (NAP-SI), but it has not been widely utilized.

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GUTTATE PSORIASISEruptive Psoriasis

More than 30% of psoriatic patients have their fi rst episodebefore age 20; in many instances, an ep-isode of guttate psoriasis is the fi rst in-dication of the patient’s propensity for the disease. Streptococcal pharyngitis or a viral upper respiratory tract infection may precede the eruption by 1 or 2 weeks. Guttate psoriasis occurs in less than 2% of cases, but it is a common psoriatic subtype in young adults. Guttate psoriasis (from the Latin gutta, meaning “a drop”) is char-acterized by eruption of small (0.5–1.5 cm in diameter) papules over the upper trunk and proximal extremities. It typically man-ifests at an early age and as such is found frequently in young adults. This form of psoriasis has the strongest association to HLACw6,26 and streptococcal throat infection frequently precedes or is concomitant with the onset or flare of guttate psoriasis. However, antibiotic treatment has not been shown to be beneficial or to shorten the disease course. Patients with a history of chronic plaque psoriasis may develop guttate lesions, with or wit out worsening of their chronic plaques. Guttate psoriasis is more commonly seen in children and ad-olescents and is frequently preceded by an upper respirato-

ry tract infection. In over half of the patients, an elevated antistreptolysin O, anti-DNase B or streptozyme titer is found, indicating a recent streptococcal infection The dis-tribution is often similar to that of classic pityriasis rosea, favoring the trunk, abdomen, and upper thighs and fading toward the acral surfaces and sparing the palms and soles

SMALL PLAQUE PSORIASIS. Small plaque psoriasis re-sembles guttate psoriasis clinically, but can be distinguished by its onset in older patients, by its chronicity, and by having somewhat larger lesions (typically 1–2 cm) that are thicker and scalier than in guttate disease. It is said to be a com-mon adult-onset presentation of psoriasis in Korea and other Asian countries.

INVERSE PSORIASISFlexural Psoriasis

The gluteal fold, axillae, groin, submam-mary folds, retroauricular fold, and the glans of the uncircumcised penis may be affected. The deep red, smooth, glistening plaques may extend to and stop at the junc-tion of the skin folds, as with intertrigo or Candida infections. The surface is moistand contains macerated white debris. In-fection, friction, and heat may induce flex-ural psoriasis, a Koebner phenomenon. Cracking and fissures are common at the base of the crease, particularly in the groin, gluteal cleft, and superior and posterior auricular folds Scaling is usually minimal or absent, and the lesions show a glossy sharply demarcated erythema, which is often localized to areas of skin-to-skin contact. Sweating is impaired in affected areas. Flexural lesions are characterized by shiny, pink to red, sharply demarcated thin plaques. There

is much less scale than in untreated chronic plaque psoria-sis. Often a central fissure is seen. The most common sites of involvement are the axillae, inguinal crease, intergluteal cleft, inframammary region and retroauricular folds. When flexural areas are the only sites of involvement, the term “in-

verse” psoriasis is sometimes used. Localized dermatophyte, candidal or bacterial infections can be a trigger for flexural psoriasis.

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ERYTHRODERMIC PSORIASIS

This variant of psoriasis is characterized by generalized erythema and scaling, and its onset can be gradual or acute. Al-though there are many causes of erythro-derma, clues to the diagnosis of psoriatic erythroderma include previous plaques in classic locations, characteristic nail chang-es, and facial sparing. Psoriatic erythroder-ma represents the generalized form of the disease that affects all body sites, includ-ing the face, hands, feet, nails, trunk, and extremities. Although all the symptoms of psoriasis are present, erythema is the most prominent feature, and scaling is different compared with chronic stationary psoria-sis. Instead of thick, a herent, white scale there is superficial scaling. Patients with erythrodermic pso-riasis lose excessive heat because of generalized vasodilata-tion, and this may cause hypothermia. Patients may shiver in an attempt to raise their body temperature. Psoriatic skin is often hypohidrotic due to occlusion of the sweat ducts, and there is an attendant risk of hyperthermia in warm climates. Lower extremity edema is common secondary to vasodila-tation and loss of protein from the blood vessels into the tis-

sues. High-output cardiac failure and impaired hepatic and renal function may also occur. Psoriatic erythroderma has a variable presentation, but two forms are thought to exist. In the first form, chronic plaque psoriasis may worsen to

involve most or all of the skin surface, and patients remain relatively responsive to therapy. In the second form, gener-alized erythroderma may present suddenly and unexpectedly or result from nontolerated external treatment (e.g., UVB, anthralin), thus representing a generalized Koebner reaction. Generalized pustular psoriasis “von Zumbusch” may revert to erythroderma with diminished or absent pustule forma-tion. Occasional diagnostic problems may arise in differenti-ating psoriatic erythroderms from other causes.

PUSTULAR PSORIAISZumbusch

Several clinical variants of pustular pso-riasis exist: generalized pustular psoriasis (von Zumbusch type), annular pustular psoriasis, impetigo herpetiformis, and two variants of localized pustular psoriasis, pustulosis palmaris et plantaris and acro-dermatitis continua of Hallopeau. In children, pustular psoriasis can be com-plicated by sterile, lytic lesions of bones and can be a manifestation of the SAPHO syndrome (synovitis, acne, pustulosis, hy-perostosis, osteitis). Generalized pustular psoriasis (von Zumbusch) is a distinctive acute variant of psoriasis. It is usually preceded by other forms of the disease. Attacks are characterized by fever that lasts several days and a sudden generalized eruption of sterile pustules 2–3 mm in diameter. The pustules are disseminated over the trunk and extremities, including the nail beds, palms, and soles. The pustules usually arise on highly erythematous

skin, first as patches and then becoming confluent as the dis-ease becomes more severe. With prolonged disease, the fin-

gertips may become atrophic. The erythema that surrounds the pustules often spreads and becomes confluent, leading to erythroderma. Characteristically, the disease occurs in waves of fevers and pustules. The etiology of generalized psoriasis von Zumbusch type is unknown.

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PUSTULOSIS OF THE PALMS AND SOLES

Deep pustules first appear on the middle portion of the palms and insteps of the soles; they may either remain localized or spread. The pustules do not rupture but turn dark brown and scaly as they reach the surface. The surrounding skin becomes pink, smooth, and tender. A thick crust may later cover the affected area. The course is chronic, lasting for years while the patientendures periods of partial remission fol-lowed by exacerbations so painful that mobility is affected. There is a consider-ably higher prevalence of smoking in these patients. Pustulosis of the palms and soles is characterized by “sterile” pustules of the palmoplantar surfaces admixed with yel-low–brown macules scaly erythematous plaques may also be seen. A minority of patients have chronic plaque psoriasis elsewhere. In contrast to the natural history of generalized pustular psoriasis, the pustules remain localized to the pal-moplantar surfaces and the course of this disease is chronic.

Focal infections and stress have been reported as triggering factors and smoking may aggravate the condition. Pustulosis of the palms and soles is one of the entities most commonly associated with sterile inflammatory bone lesions, for which

there are several names: chronic recurrent multifocal osteo-myelitis, pustulotic arthro-osteitis, and SAPHO syndrome, which consists of synovitis, acne, pustulosis, hyperostosis and osteitis. Several neutrophilic dermatoses are associated with SAPHO.

SCALP PSORIASISPlaques, sharply marginated, with thick adherent scales. Of-ten very pruritic. Psoriasis of the scalp does not lead to hairloss. Scalp psoriasis may be part of generalized psoriasis or the only site involved. The scalp is one of the most common sites for psoriasis. Un-less there is complete confluence, the indi-vidual lesions are discrete, in contrast to the less well-defined areas of involvement in seborrheic dermatitis. At times, however, it is not possible to distinguish seborrheic dermatitis from psoriasis, and the two dis-orders may coexist. The lesions of psoria-sis often advance onto the periphery of the face, the retroauricular areas and the upper neck. The scales sometimes have an asbes-toslike appearance and can be attached for some distance to the scalp hairs (pityriasis amiantacea). Although pityriasis amianta-cea can also be seen in patients with sebor-rheic dermatitis, secondarily infected atopic dermatitis and tinea capitis, psoriasis is the most common cause. Alopecia occasionally develops within involved areas. In addition,patients with dermatomyositis involving the scalp may havelesions that resemble psoriasis.

SEBOPSORIASIS: A common clinical entity, sebopsoriasispresents with erythematous plaques with greasy scales lo-calized to seborrheic areas (scalp, glabella, nasolabial folds, perioral and presternal areas, and intertriginous areas). In the absence of typical findings of psoriasis elsewhere, dis-

tinction from seborrheic dermatitis is difficult. Sebopsoriasis may represent a modification of seborrheic dermatitis by the genetic background of psoriasis and is relatively resistant totreatment.

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PSORIASIS OF THE PALMS AND SOLES

May be the only areas involved. There is massive silvery white or yellowish hyper-keratosis, which is not easily removed. The inflammatory plaque at the base is always sharply demarcated. There may be crack-ing, painful fissures and bleeding.The palms and soles may be involved as part of a generalized eruption, or they may be the only locations involved in the man-ifestation of the disease. There are several presentations. Superficial red plaques with thick brown scale may be indistinguisha-ble from chronic eczema. Smooth, deep red plaques are similar to those found in the flexural area.

PSORIASIS OF THE NAILS

Nail changes are characteristic of psoriasis and the nails ofpatients should be examined. These changes offer support-ing evidence for the diagnosis of psoriasis when skin changes are equivocal or absent. Nail involvement has been reported in 10–80% of psoriatic patients, depend-ing upon the series. The fingernails are more often affected than the toenails. In a survey from the Netherlands, 79% of pa-tients reported involvement of their nails, with 52% experiencing associated pain and 14% major restrictions in daily life due to the nail changes. Patients with nail involvement appear to have an increased incidence of psoriatic arthritis. Psoriasis affects the nail matrix, nail bed and hypon-ychium. Small parakeratotic foci in the proximal portion of the nail matrix lead to pits in the nails. Leukonychia and loss of transparency (less common findings) are due to involvement of the mid portion of the matrix. If the whole nail matrix is involved, a whitish, crumbly, poorly adherent “nail” is seen. Psoriatic changes of the nail bed result in the “oil spot” or “oil drop” phenom-

enon, which reflects exocytosis of leukocytes beneath the nail plate. Splinter hemorrhages are the result of increased capillary fragility, and subungual hyperkeratosis and distal onycholysis are due to parakeratosis of the distal nail bed. Vigorous removal of distal subungual debris may be an ex-acerbating factor. Fingernails and toenails frequently (25%)

involved, especially with concomitant arthritis. Nail chang-es include pitting, subungual hyperkeratosis, onycholysis, and yellowish-brown spots under the nail plate—the oil spot (pathognomonic).

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PSORIASIS IN CHILDHOOD

The Psoriasis can occur in any age, half of the cases start at puberty or early adult-hood. However, it is not rare in children, and even psoriatic disease begins in infan-cy. Psoriasis in children most often appears on the scalp, the diaper area, the armpits and elbows and knees surface. Psoriasis in children, there is another form: in tod-dlers on the diaper area. In this case these plaques do not appear; it makes more diffi-cult for non-professional people to identify the disease. Often they confuse with diaper rash, and infants can get wrong treatment. It is important that dermatologist can see

the little patient.

ATOPIC SYMPTOMS ANDATYPICAL APPEARANCE IN

INFANCY

The atopic symptoms: persistent, red, scaly skin inflamma-tion are primarily around the joints, knees, over ankles and scalp. In childhood not just the atypical symptoms occur, which make it difficult to recognize the disease for non-spe-cialists. In infantile, psoriasis appears as most often on the diaper area with the symptoms: persistent, with convention-al treatment does not heal, bright red, crisp edges discrete inflammation (diaper psoriasis). It occurs also on the folds (armpits, naval - psoriasis inverse) and the scalp (psoriasis capitis, corona psoriasis arthritis). In childhood, scalp disor-ders are also common, as well as everywhere on the body, specially around the torso 0.5-2 cm diameter scaly, itchy symptoms, they are often mild scattered ( psoriasis guttate). In children psoriasis disorders often appear on the face. In children the most frequent type of psoriasis is plaque (74%), and approximately 14% is guttate, while erythrodermic and pustular types occur rarely. At the same time children’s pso-riasis skin is thinner then the adult’s and peel less. Psoriasis in children, nail disorders are very frequent, the pitting of the nails is the most typical, around 70% of the occurences. Nail diseases go before skin problems. Hyperkeratosis is often as-sociated with pitting of the nails.

The Psorioasis guttate occurs approxiametly at 14% in childhood. The spotted psoriasis is a type occures in child-hood or young adulthood. The word (spotted) has Latin ori-gin, meaning „drop.” At this psoriasis, tiny red spotscover the patient’s skin. The sores appear usually on the patient’s torso and limbs, and the spots are not as extensive as the wounds of

the stained psoriasis. The spotted psoriasis comes out often quite suddenly. There are several conditions what result the development of psoriasis: upper respiratory infections, strep-tococcal infections, tonsillitis, stress, injury on the skin, cer-

tain medications (including beta-blockers and anti-malaria drugs). A streptococcal pharyngitis is frequently evocative in the psoriasis spotted.

INHERITANCEThe Psoriasis in infant or children, inheritance is a high prob-ability factors. The psoriasis taint is innate, the taint is en-coded in our genes; which we inherite from our parents. (In identical twins, if one of the twin has psoriasis, the n it is 90% chance the other will have also). If both parents have it, then it is 60-75% chance that the child will have it. So one or botheof the parent have it or carry the defective genes.

A STRONG CORRELATION WITH CHILDHOOD OBESITY!According to analytical view there is link between the psori-asis and the overweight, 93% of the children have increased obesity before the appearance of psoriasis. In addition, 78 percent of patients have obesity before the onset of psoriasis. Obesity, hypertension, hyperlipidemia, and diabetes occurred more frequently in children suffering from psoriasis, but the closest relationship is obesity!

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“PSYCHOLOGICAL SYMPTOMS ASSOCIATED WITH SKIN

DISEASES”

A skin lesion is often accompanied by shame, depression. With the suitable prod-ucts and the harmonic environment pro-motes healing. Everyone needs to live a meaningful life without a sense of shame and without psychological complaints.

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HUMAN RELATIONSHIP

The touch, the caress are important part of human relation-ships, and of emotional expressions. Whether mother–child or male-female relationship. A disturbing skin condition can blast them in the intimate coexistence. What skin diseases can be accompanied with mental complaints, which may make it harder each and every day?

ATOPY AND ECZEMA

The inflamed, sore body surface area is not a pretty vision, to touch could cause pain. In additionally if it appears to on a place what cannot be covered with a cloth, the frustration can intensify. Furthermore, the genetic predisposition, the stress also plays a major role in formation of the skin diseases with the origin of the allergic reaction. From the very early child-hood the psychological difficulties may begin to accumulate, the continuous failure only increases the chances of skin le-sions. The dry and very itchy and sore skin in the folds and extremities are the most common. However, special creams can make the skin asymptomatic. In addition, it is important to identify and resolve the psychological problems behind the skin disease.

PSORIASIS

Psoriasis which occurs with inflammatory skin symptoms and with dry itchy skin it makes difficulties for the affected people not only physically, but also spiritually because of the visible and tangible signs. Trauma, long time restlessness, stress can cause the presence of the psoriasis. The disease is exacerbated by constant tension. A peeling, red, scaly, itchy scalp undermines self esteem. Psoriasis usually appears at the border of the forehead and the scalp, but it can occur also in the folds. Fortunately, there are plenty of methods of treat-ment, so the diseases can be remediable. For the scalp treat-ment it is important to use the correct product, what does not make the hair pallid, unmanageable, oily, and in the mean-time also eliminates the itching. The scratching enhances the feeling that causes avoiding the social life.

Important! Head-to-toe, the continuous body care is impor-tant for youngs and elders as well. Do not wait until a prob-lem domineers. Pay attention with great care to pamper the sensitive, deficient of nutrient and got dry skin caused of the winter . It is important to incorporate the everyday routine ofhydration, and the treatment of inflammation. The cosmetics containing plant extracts, vitamins, minerals are excellent, because they calm and nourish the skin. It is never enough just to care about the visible spots, but the whole body should be puttyed.

WHAT THE IDEAL PRODUCTS CAN:

During the selection of the natural materials we look for the soothing, anti-inflammatory, regenerative, antibacterial and anti-fungal effects; we prefer the active ingredients, which nurture, nourish and protect the dry inflamed skin; their re-freshing invigorating ingredients will enhance the growth of cells, such: Soothed the irritated skin, attenuate, eliminate the itching, the irritation, reduce the skin peeling, because of the high moisture content, they regenerate the dry cracked skin, effectively replace the lacking fat of the skin, if it is possible, they do not contain any sulfur, tar or steroids.

WHAT DOES THE DERMATOLOGIST SUGGEST?

In summary, we can say that although psoriasis cannot be cured, but with suitable individualized treatment, the skin disease can be maintained well that needs dermatologist care and the patient-physician good co-operation. The eczema, atopic and sensitive skin mostly tolerates the salicylic-acid free products because in theese cases the most important is to smooth the skin. Although it is not easy, but we must try to re-duce the stress, deliberately use relaxation techniques, con-sciously slow down the pace. With therapeutic tools and fine methods we care about our soul, but our body needs physical care. With more and more care about your skin, it will benefit from maintenance, then the the soul may have take off eas-ier the armor. Paraben and salicylic acid free Psorioderm ® Sensitive Products are recommended for the eczema, atopic, psoriasis and seborrheic skin for daily care, even un-der the age of 3. They contain jojoba and honey extracts, contents of Shea butter plus vitamin E. It is satisfaction that Hungarian innovated products are available and they suc-cessfully take up the fight against the plaque psoriasis. The Psorioderm ® Product Line contains only natural products, and in 2012 and 2013, a professional jury honoured them for Hungarian Quality Product Award! For plaques peeling, the Psorioderm ® products contain salicylic acid that is why it is not recommended for use under the age of 3. For babies and adults with sensitive skin, we suggest the salicylic acid-free Psorioderm Sensitive ® product line that with added jojoba and honey extracts make your skin soften! The Sensitive Psorioderm product line in 2013 won the Hungarian Quality Product Award! At the Derma-Art Dermatology Clinic, we recommend the Psorioderm Sensitive product line for sensi-tive skin, and for under three years of age. For children over three years old, and adults can already use the Psorioderm product line! In summary, we can say that although psoriasis cannot be cured, but with suitable individualized treatment, the skin disease can be maintained well that needs derma-tologist care and the patient - physician good co-operation.

Dr. Gyöngyike Beleznay. Dermatologist.Member of American Academy Of Dermatology

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“HIDING IS NOT AN OPTION”Emotional distancing, alienation ... Psoriasis is a highly visible disease that affects about 2 percent of the population, and cannot pick between men and women. Struggling with lesions on the skin, people face difficulty, when other look at them due to the visible lesions.

WHAT MAKES WOMEN MORE AFRAID OF PSORIASIS?

After the research from America, the detection of the disease causes more serious spiritual crisis at the women, then the men. Due to the spectacular symptoms of the disease can be a block among the effected women and her loved ones. The physical separation is considered, an emotional separation by time it destroys the relationships with family and close friends. According to the study the not coverable spots cause the biggest emotional hurt at the women, those spots are not viewable can lead to psychological injury later. The psoriasis on the head and around the hair disturb women mostly, be-cause it may create the appearance of undemanding. The sur-veyed doctors say about the research, that these feelings ap-pear at men as well as women, but women are more likely to cry and freak-out even in the office, during their visits at the dermatologist. It was interesting what the surveyed doctors noticed, that not the seriousness of the disease overturning emotional intensity, but the visibility of the disease. In addi-tion, psoriasis patients’ partners often accept the disease, the intimate together will not disappear because of the healthy half, but because of the patients who rejects these occasions, they can not accept themselves.

INSTEAD OF COVER, CARE ABOUT IT

In today’s fast-paced world the biggest platitudes becoming the soullessness, the superficiality and stolidity living area. Here, the sensitive man “grows” armour, and wears costume or mask. In psoriasis, many people labour under a delusion. The biggest disbelief is that it is infectious, and we cannot do anything about it. However, many external factors play a role in the development and severity of symptoms, which can be influenced. There is a chance to keep the symptoms at bay by lifestyle change and the right decisions regarding the care of the disease. Especially important in the case of skin diseases that our body can contact with good quality products, what contain active substances. The gradual improvement increas-es the self-confidence and the soul rejuvenation.It is better the lasting improvement instead of the rapid: The conventional medicine prefers the steroid solutions which improvements can be shortly spectacular. But after leaving the steroid you can see setback, the immune system can pro-duce stronger and stronger symptoms, due to the negative effects of the steroids, what weakens more and more our protector system. Without a holistic approach, you cannot control. First, next to the physical symptom management, psychological care is needed, as at almost all patients; the de-velopment of symptoms is associated with the psychological factors. On the other hand, the holistic approach also means that we do not only deal with problematic skin, but we care about the body with products containing specific active in-gredients. Not enough the oily, it should be nutritious: The

only fat creams help in softening the scales, but did not care the inflammation skin under the horny layer. In addition, the fats the body needs suitable ingredients extracted from nat-ural active, what contribute to the skin nutrition, hydration; to calm, and to remove the unnecessary epidermal layers as well.

HUNGARIAN QUALITY THAT HELPS YOU LIVE BETTER QUALITY LIVE

The good news is that you can find in home (Hungary) lo-cally produced quality domestic cosmetics for psoriatic skin. At the Dermatology Clinic of the University of Debrecen, DEOEC the research confirmed the effectiveness our prod-ucts. The comparative study was partially placebo-con-trolled, double-blind parallel-label, with the mild to moderate plaque psoriasis patients. The research showed that by the Hungarian Psorioderm Laboratories Ltd. developed cosmet-ics can significantly relieve symptoms and reduce the fre-quency of the steroids needs for psoriasis patients. Thanks to its active-rich ingredients what can make the positive change during the daily care. The Psorioderm products are composed from carefully selected natural ingredients, they are fragrance-free, paraben-free, tar-free and all the other “negative” matter-free. Due to the herbal extracts, Dead Sea salts, natural plant oils, vitamins, and minerals our products help to nourish the skin properly, hydrate, soothe, and help to remove redundant skin tissues.

WHAT DOES THE DERMATOLOGIST SUGGEST?

It is satisfaction that Hungarian innovated products are avail-able and they successfully take up the fight against the plaque psoriasis. The Psorioderm ® Product Line contains only natural products, and in 2012 and 2013, a professional jury honoured them for Hungarian Quality Product Award! For plaques peeling, the Psorioderm ® products contain salicylic acid that is why it is not recommended for use under the age of 3. For babies and adults with sensitive skin, we suggest the salicylic acid-free Psorioderm Sensitive ® product line that with added jojoba and honey extracts make your skin soften! The Sensitive Psorioderm product line in 2013 won the Hun-garian Quality Product Award! At the Derma-Art Dermatol-ogy Clinic, we recommend the Psorioderm Sensitive product line for sensitive skin, and for under three years of age. For children over three years old, and adults can already use the Psorioderm product line! In summary, we can say that al-though psoriasis cannot be cured, but with suitable individu-alized treatment, the skin disease can be maintained well that needs dermatologist care and the patient - physician good co-operation.

Dr. Gyöngyike Beleznay. Dermatologist.Member of American Academy Of Dermatology

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The essence of ancient cures, or naturally skincare.The Hungarian Quality Product Award honoured Psorioderm line’s effect is proven by clinical trials!The members of the product line are good for care about the psoriasis, eczema, skin showing signs of seborrhoea; and for the highly dandruff, psoriasis, seborrhoea, itchy, sensitive scalp daily care.

PSORIODERM

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PSORIODERMPRODUCT LINE

After a two-year- research in 2010 Pezomed Group developed and introduced to the market Psorioderm product line which recommended for psoriasis, eczematous and atopic skin. The Hungarian Quality Product Award hon-oured Psorioderm line’s effect is proven by clinical trials!The members of the product line are good for care about the psoriasis, eczema, skin showing signs of seborrhoea; and for the highly dandruff, psoriasis, seborrhoea, itchy, sensitive scalp daily care. You can use several times the Psorioderm ® products during the daily skin care. The products are composed of attentively selected natural ingre-dients and help to make your skin healthier. This uniquely developed product line is made of the finest materials: they are rich in nourishing ingredients, like plant extracts and oils, Dead Sea salt, vitamins, minerals. The products soothe the irritated skin, soothe itching and reduce skin peeling. Due to its high moisture content regenerate dry chappy skin. They has positive effect on the general condition of the inflamed skin. The special and active ingre-dients prevent the exfoliation process and eliminate irritation, itching.

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PSORIODERM CREAM (50ml, 100ml, 200ml)

The Hungarian Quality Product Award honoured Psorioderm cream, its effect is proven by clinical trials! For psoriasis, seborrhoea skin care. It is composed of attentively select-ed natural ingredients, vitamins, trace elements. Intensive nourishing cream for everyday use. Due to the substances, it has effective and natural nurse for dry, sensitive and irri-tated, psoriasis, eczema skin. Special ingredients moisturise the skin and help in getting back the lost fluid and improve the comfort of the skin. Suitable for daily care for the skin has symptoms of psoriasis, eczema, seborrhoea dermatitis. Due to its high moisture content, it helps to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral content of the skin, increasing the resistance. It effectively helps to fill in the missing fatties of the skin, interferre the fluid loss, soothes and nourishes the skin during the hole the day. Paraben-free, dermatologically tested. It does not con-tain any artificial colours, fragrances do not contain any al-lergenic ingredients.

PSORIODERM SHAMPOO (250ml)

The Hungarian Quality Product Award honoured Psorioderm shampoo, its effect is proven by clinical trials! For psoria-sis, seborrhoea skin care. Psorioderm shampoo is composed of attentively selected natural ingredients, vitamins, trace elements. Intensive nourishing shampoo for everyday use. Suitable for the very scaly, psoriasis, seborrhoeic, itchy, es-pecially sensitive scalp care.It has haircare, conditioner and intensive soothing effects. The active ingredients of the Psorioderm shampoo effec-tively help replace the missing fat of the skin, the comfort feeling of the scalp is improved, and avoided the dry skin. Paraben-free, dermatologically tested. The special and active ingredients of Psorioderm shampoo prevent the exfoliation process and eliminate irritation, itching.Psorioderm Shampoo enriched with vegetable oils, such as suggested at least twice in a row to wash the scalp, then rinse thoroughly. Externally applied. Not recommended under 3 year old because of salicylic acid content. It is important psoriasis and seborrhoea appear on the scalp, not on the hair. Therefore, use two to three times a week, or even daily care of the scalp.

PSORIODERM BODY LOTION (250ml)

The Hungarian Quality Product Award honoured Psorioderm body lotion; its effect is proven by clinical trials! For psori-asis, seborrhoea skin care. The body lotion is composed of attentively selected natural ingredients, vitamins, trace ele-ments. Intensive nourishing body lotion for everyday use. Due to the substances, it has effective and natural nurse for dry, sensitive and irritated, psoriasis, eczema skin. Intensive nourishing body lotion for everyday use. Special ingredients moisturise the skin and help in getting back the lost fluid and improve the comfort of the skin.The Psorioderm body lotion is suitable for daily care for the skin has symptoms of psoriasis, eczema, seborrhoea derma-titis. Due to its high moisture content, it help to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral content of the skin, increasing the resistance. It effec-tively helps to fill in the missing fatties of the skin, interferre the fluid loss, soothes and nourishes the skin during the hole the day. It has soothing, nourishing effect. Paraben-free, dermatologically tested. It does not contain any artificial col-ours, fragrances do not contain any allergenic ingredients.

PSORIODERM SHOWER GEL (250ml)

The Hungarian Quality Product Award honoured Psorioderm Shower gel; its effect is proven by clinical trials! For pso-riasis, seborrhoea skin care. It is composed of attentively selected natural ingredients, vitamins, trace elements. In-tensive nourishing shower gel for everyday use. Due to the substances, it has effective and natural nurse for dry, sensi-tive and irritated, psoriasis, eczema skin. Special ingredients moisturise the skin and help in getting back the lost fluid.The Psorioderm Shower gel gently cleanses the skin and in the same time to store its oils to prevent the dehydration. During the shower it replaces the missing fat of the skin, thereby inhibiting the fluid loss by this it can help prevent the skin from drying out. The Dead Sea salt regulates the mineral content of the skin, increasing the resistance. The Psorioderm shower gel nourishes the skin during the hole the day. Paraben-free, dermatologically tested. It does not contain any artificial colours, fragrances do not contain any allergenic ingredients.

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In 2012 year it was 15th time, when the ceremony of the Hungarian Quality Product Award was or-ganized. This award symbolizes the continuously controlled, extremely high quality products and related services. Those products, ser-vices and enterprises can get the honourable title, who are committed to the high-qual-ity services and high quality products

The Hungarian owned group company developed the prod-uct with two years of research work, then in 2010 introduced that to the Hungarian market. This developed product line is good for psoriasis, seborrhea, atopy and eczema care, in September of 2012 it won the Hungarian Quality Product Award.

Psoriasis is a chronic, currently incurable skin disease. Not only physically, but also because of the vis-

ible and tangible signs it makes the life more difficult for the effected pa-

tients. Firstly, it attacks the skin, nails and joints, most often it ap-

pears on the extremities and on the scalp. It can happen that the disease goes on the joints, causing painful swelling.

Psoriasis does not infect how-ever the wrong belief says.

Psoriasis makes difficulties for 400 thousand people everyday in

Hungary; the seborrhea affects the 60 percent of the people.

Pezomed Ltd was attentive to that fact when manufactured the Psorioderm® product line. The herbal extracts, aloe vera, essential fatty acids (omega-3, -6), Dead Sea salts, shea but-ter, salicylic acid, tea tree oil extract, zeolites, trace elements and vitamins containing products passed the clinical test suc-cessfully: at the University of Debrecen Medical Health Cen-trer Dermatology Clinic - double-blind placebo controlled trial showed the result as the daily use of the cream is good to alleviate the symptoms of psoriasis and may reduce the demand of the topical steroids, thus mitigate their adverse effects. The study was supervised by Prof Dr. Eva Remenyik, the doctor of the MTA (Hungarian Academy of Sciences), university teacher, director of the clinic at the Debrecen Med-ical and Health Science Centrer, Department of Dermatology Clinic.

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PSORIODERM PRODUCTS:Hungarian Quality Product

Award 2012

30

Psorioderm® product linePsorioderm® product line is a natural daily care of psoriatic and seborrhoeic skin-prob-lems. Contains the finest ingredients - like plant extracts and oils, Dead Sea salt, vitamins, minerals - with rich nourishing effect, deeply moisturizes, soothes and calms dry, irritat-ed, inflamed, flaking and itching skin.Its effect was proved in a double blinded placebo-controlled study, which has stated:

- Psorioderm can alleviate the psoriatic symptomps.- May reduce the requirements of topical steroid.

Regular, every day usage of the preparations helps to improve the quality of life.It does not contain steroids, paraben, artificial colouring and perfume. Because of the sal-icylic acid content, the products are not recommended to use for children under 3 years. Psorioderm® product family has won the Hungarian Quality Product Award in 2012!

Psorioderm® CreamThe Cream is suitable for daily care of the skin, that has symptoms of psoriasis and seborrhoeic dermatitis. It is composed of attentively selected natural ingredients, vitamins and trace elements. These special ingre-dients are deeply nourishing and moisturizing the dry and dehydrated skin, improving its comfort. Enriched with Dead Sea Salt that reinforces the natural protective barrier that regulates the mineral content of the skin. Paraben-free, colourant-free, its fragrance does not contain any allergenic ingredients. Dermatologically test-ed.

Application: It can be used after the daily body wash, but also several times per a day as it is required in the area of irritated skin. You can apply the cream liberally, then wait a few minutes for complete absorption. Externally applied.

Ingredients (INCI): Aqua, Propylene Glycol, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Isopropyl Myristate, Polyglyceryl-3 Methylglucose Distearate, Stearic Acid, Borago Officinalis Seed Oil, PEG 40, Hydrogenated Castor Oil, Urea, Glycerin, Cocos Nucifera Oil, Olea Europaea Oil, Panthenol, Theobroma Cacao Butter, Ribes Nigrum Oil, Triticum Vulgare Germ Oil, Persea Gratissima Oil, Lanolin, Maris Sal, Phenethyl Alcohol, Salicylic Acid, Tocopheryl Acetate, Dimethicone, Caprylyl Glycol, Aloe Barbadensis Leaf Extract, Parfume, Lavandula Angustifolia Oil, Bisabolol, Calendula Officinalis Extract, Polysorbate 80, Zeolite, Avena Sativa Straw Extract, Helianthus Annuus Seed Oil, Tocopherol, Glyceryl Linoleate, Beta-sitosterol, Squalane

Just rely on the power of nature!

50, 100, 200 ml

250 ml

www.psorioderm.com

Psorioderm® Body LotionThe Body lotion is suitable for daily care of the skin which has symptoms of psoriasis and seborrhoeic der-matitis. It is composed of attentively selected natural ingredients, vitamins and trace elements. Due to its high moisturizing components, it helps to nourish the dry and dehydrated skin improving its comfort. Enriched with Dead Sea Salt that reinforces the natural protective barrier that regulates the mineral content of the skin. Paraben-free, colourant-free, its fragrance does not contain any allergenic ingredients. Dermatologically tested.

Application: You can use after the daily body wash, but if it is needed even several times per a day on the af-fected area. Generously apply the lotion on the skin, gentle strokes to distribute, and then wait a few minutes for complete absorption. Externally applied.

Ingredients (INCI): Aqua, Propylene Glycol, Cetearyl Alcohol, Isopropyl Myristate, Polyglyceryl-3 Methylglucose Distearate, Stearic Acid, Butyrospermum Parkii (Shea) Butter, Urea, PEG 40 Hydrogenated Castor Oil, Cocos Nucifera Oil, Ribes Nigrum Oil, Olea Europaea Oil, Lanolin, Theobroma Cacao But-ter, Maris Sal, Glycerin, Borago Officinalis Seed Oil, Panthenol, Phenethyl Alcohol, Carbomer, Salicylic Acid, Dimethicone, Triticum Vulgare Germ Oil, Tocopheryl Acetate, Persea Gratissima Oil, Caprylyl Gly-col, Sodium Hydroxide, Aloe Barbadensis Leaf Extract, Parfume, Lavandula Angustifolia Oil, Bisabolol, Calendula Officinalis Extract, Zeolite, Avena Sativa Straw Extract, Helianthus Annuus Seed Oil, Polysorbate 80, Tocopherol, Glyceryl Linoleate, Beta-sitosterol, Squalane.

31

Psorioderm® Shower Gel

The Shower gel is an intensive nourishing gel for daily use of psoriasis, seborrhoeic skin hygiene. It is composed of attentively selected natural ingredients, vitamins, trace elements. Its special components gen-tly clean and moisturize the skin and help to get back the lost fluid and store its oils to prevent dehydra-tion. Enriched with Dead Sea Salt that reinforces the natural protective barrier that regulates the mineral content of the skin. Paraben-free, colourant-free, its fragrance does not contain any allergenic ingredients. Dermatologically tested.

Application: First take a shower gel to the wet skin during daily body wash, then after having bath rinse it off. Dry the skin without rubbing. Externally applied.

Ingredients (INCI): Aqua, Disodium Cocoamphodiacetate, Propylene Glycol, Cocamidopropyl Betaine, So-dium Lauroyl Sarcosinate, Laureth-2, Glycerin, PEG-90 Glyceryl Isostearate, Aloe Barbadensis Leaf Extract, Avena Sativa Straw Extract, Melaleuca Alternifolia Leaf Oil, Juniperrus Communis Wood Oil, Helianthus Annuus Seed Oil, Lavandula Angustifolia Oil, Panthenol, Tocopherol, Beta-Sitosterol, Salicylic Acid, Maris Sal, Lactic Acid, Squalane, Glyceryl Linoleate, Iodopropynyl Butylcarbamate, PEG-8, Disodium EDTA, DMDM Hydantoin, Parfum.

Just rely on the power of nature!

250 ml

250 ml

www.psorioderm.com

The regular usage from had to toe of all 4 products has a strong synergic effect.

Psorioderm® Shampoo

The Shampoo is composed of attentively selected natural ingredients, vitamins, trace elements for psoriasis and seborrhoeic skin care. The intensive nourishing shampoo is suitable for the very scaly, psoriatic, sebor-rheic, itchy, especially sensitive scalp care. It has caring, conditioning and intensive soothing effect. Its active ingredients help to replace the missing fats of the skin and improve comfort of the scalp. Paraben-free, colour-ant-free, its fragrance does not contain any allergenic ingredients. Dermatologically tested.

Application: Use twice or three times per a week, or even every day. Leave the foam on the scalp for five minutes, then rinse thoroughly. The hair will be easy to comb. Externally applied.

Ingredients (INCI): Aqua, Disodium Cocoamphodiacetate, Propylene Glycol, Cocamidopropyl Betaine, Sodium Lauroyl Sarcosinate, Laureth-2, Glycerin, PEG-90 Glyceryl Isostearate, DMDM Hydantoin, Sal-icylic Acid, Maris Sal, PEG-8, Lactic Acid, Lavandula Angustifolia Oil, Disodium EDTA, Iodopropynyl Butylcarbamate, Helianthus Annuus Seed Oil, Tocopherol, Glyceryl Linoleate, Beta-sitosterol, Squalane, Aloe Barbadensis Leaf Extract, Panthenol, Ribes Nigrum Oil, Juniperus Communis Oil, Melaleuca Alternifolia Leaf Oil, Bisabolol, Avena Sativa Straw Extract, Parfume.

RECOMMENDED FOR WEEKLY USAGE

Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7

Sensitive Cream

Sensitive Body Balm

Sensitive Shampoo

Sensitive Shower gel

RECOMMENDED FOR WEEKLY USAGE

Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7

Cream

Body Balm

Shampoo

Shower gel

32

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The Hungarian Quality Product Award honored, paraben- and salicylic acid-free Psorioderm® Sen-sitive Product Line is good for eczema, atopic, pso-riasis and seborrheic skin for daily care, even under the age of 3. They contain jojoba and honey ex-tracts, contents of Shea butter plus vitamin E.

PSORIODERMSENSITIVE

PSORIODERMSENSITIVE

PRODUCT LINEPezomed Group introduced to the market Psorioderm Sensitive line in 2012 recommended for psoriasis, seborrhoea, eczem-atous, atopic skin, which won Hungarian Quality Product Award in 2013. The Hungarian Quality Product Award honoured, paraben and salicylic acid-free Psorioderm® Sensitive Product Line is good for eczema, atopic, psoriasis and seborrhoeic skin for daily care, even under the age of 3. They contain jojoba and honey extracts, contents of Shea butter plus vitamin E. By the natural ingredients the Psorioderm® Sensitive product line nurses, cares and soothes the dry, sensitive and irritated skin and improve its comfort feeling. Due to its high moisture content, it help to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral content of the skin, increasing the resistance. The Psorioderm Sensitive Products effectively help to fill in the missing fatties of the skin, interferre the fluid loss, soothe and nourishes the skin during the hole the day. It is paraben and salicylic acid-free, artificial colours-free and dermatologically tested. The fragrances of the Psorioderm® Sensitive prod-uct line do not contain any allergenic ingredients, that is why they are good for babies’ and toddlers’ dry and sensitive skin also. The Psorioderm® Sensitive product line are available in cream, body lotion, shower gel and shampoo products.

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PSORIODERM SENSITIVE CREAM (50ml, 100ml,)

The Hungarian Quality Product Award honoured Psorioderm® cream. For babies’ and toddlers’ sensitive skin also. The paraben and salicylic acid-free Sensitive Cream is good for eczema, atopic, psoriasis and seborrhoea skin for daily care. The cream contains jojoba and honey extracts, contents of Shea butter plus vitamin E. Recommended to ap-ply for daily use. By the natural ingredients it nurses, cares and soothes the dry, sensitive and irritated skin and improve its comfort feeling. Due to its high moisture content, it help to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral content of the skin, increasing the re-sistance. The Psorioderm® Sensitive Cream effectively helps to fill in the missing fatties of the skin, interferre the fluid loss, soothes and nourishes the skin during the hole the day. Paraben-free, dermatologically tested. It does not con-tain any artificial colours, fragrances do not contain any al-lergenic ingredients. For babies’ and toddlers’ sensitive skin also.

PSORIODERM SENSITIVE SHAMPOO (250ml)

The Hungarian Quality Product Award honoured Psorioderm® Sensitive Shampoo. For babies’ and toddlers’ sensitive scalp also. The paraben and salicylic acid-free Sensitive Sham-poo is for cleaning the specifically sensitive and vulnerable scalp. For babies’ and children’s hair wash. It also cares the psoriasis and seborrhoeic scalp.It moisturise the scalp and the hair with the herbal agents and the added jojoba, honey extracts, and with the shea butter plus vitamin E. The salicylic acid-free, paraben-free and ar-tificial colour free Sensitive Shampoo is composed of atten-tively selected natural ingredients, vitamins, trace elements. Intensive nourishing shampoo for everyday use for clean-ing the specifically sensitive and vulnerable scalp. It effec-tively helps replace the missing fat of the skin, the comfort feeling of the scalp is improved, and avoided the dry skin. Salicylic acid-free, paraben-free and artificial colour free. Dermatologically tested. After hair wash, rinse thoroughly because of the herbal oils.

35

PSORIODERM SENSITIVE BODY LOTION

(250ml)

The Hungarian Quality Product Award honoured Psorioderm body lotion. For babies’ and toddlers’ sensitive skin also.The paraben and salicylic acid-free Sensitive Body Lotion is good for eczema, atopic, psoriasis and seborrhoeic skin for daily care. The body lotion contains jojoba and honey extracts, con-tents of shea butter plus vitamin E. Recommended to apply for daily use. By the natural ingredients it nurses, cares and soothes the dry, sensitive and irritated skin and improve its comfort feel-ing. Due to its high moisture content, it help to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral content of the skin, increasing the resistance. The Psorioderm Sensitive Body Lotion effectively helps to fill in the missing fat-ties of the skin, interferre the fluid loss, soothes and nourishes the skin during the hole the day. It is paraben and salicylic ac-id-free, dermatologically tested. It does not contain any artificial colours, fragrances do not contain any allergenic ingredients. For babies’ and toddlers’ dry and sensitive skin also.

PSORIODERM SENSITIVE SHOWER GEL

(250ml)

The Hungarian Quality Product Award honoured Psorioderm® shower gel. For babies’ and toddlers’ sensitive skin also. The paraben and salicylic acid-free Sensitive Shower Gel is good for eczema, atopic, psoriasis and seborrhoea skin for daily care. The Psorioderm® Sensitive shower gel gently cleans the sensi-tive and vulnerable skin. It moisturise the skin with the herbal agents and the added jojoba, honey extracts, and with the shea butter plus vitamin E. It is recommended for daily use. The paraben and salicylic acid-free Sensitive Shower Gel is good for eczema, atopic, psoriasis and seborrhoea skin for daily care.By the natural ingredients it nurses, cares and soothes the dry, sensitive and irritated skin and improve its comfort feeling. Due to its high moisture content, it help to moisture the dry and dehydrated skin. The Dead Sea salt regulates the mineral. The Psorioderm Sensitive shower gel gently cleans the sensitive and vulnerable skin. It moisturise the skin with the herbal agents and the added jojoba, honey extracts, and with the shea butter plus vitamin E. It is recommended for daily use. Dermatologically tested.

36

Psorioderm ® Sensitive product line for eczema, atopic, psoriasis skin: cream, body lotion, bath gel, shampoo won the Hungarian Quality Product Award in 2013. This award symbolizes the continuous-ly controlled, extremely high quali-ty products and related services. Those products, services and en-terprises can get the honourable title, who are committed to the high-quality services and high quality products

The Hungarian Quality Product Award ® tender kindles the com-petition of quality; to reach that, fresh approach, regeneration capacity, innovation are needed. This is the pillar of the work-based economic, of the industry, where the main accent is on the industry, production, up to par qualitative product or the high-quality service. Togeth-er, it represents high value-added in commercial and social

media content as well. The new economic policy welcomes and rewards the entrepreneur, who makes product or service,

which can be exportable to all regions. During the 16 years of the noble competition to win

the Hungarian Quality Product Award ®, the participants: the products,

technologies, processes, services and producers, they are the trus-tee and transmitter of the worth. These values are in line with the interests of our country’s econ-omy, contribute to the achieve-

ment of a stronger economy. The honouring title and the evi-

dentiary trademark of the Hungarian Quality Product Award ® become the

“European passport of the certified quali-ty” ! The success of the 16 years consistent work

confirmed that the QUALITY CREATED TRADITION!

PSORIODERM SENSITIVE:Hungarian Quality Product

Award 2013

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38

Psorioderm® SENSITIVE product line

Sensitive, dry, irritated and also eczematic and atopic skin needs special care. Psorioderm® SENSITIVE product family was developed to provide this special care for babies, chil-dren and adults for dry, irritated eczematous, atopic skin problems, and also for people who has psoriatic and seborrhoeic skin but suffering from salicylic acid- intolerance, since the products moderates the cracked skin on plaque psoriasis and seborrhoea.Psorioderm® SENSITIVE line nourishes, moisturises, rejuvenates and intensifies the comfort level of dehydrated skin. Each member of the family is enriched with cocoa but-ter, olive oil, coconut, wheat germ, avocado, lavender, borago, black currant, calendula, aloe vera, oat, vitamin A with additional honey, extra jojoba oil, vitamin E and shea butter for a more gentle care. The products are dermatologically tested. Free from salicylic acid, paraben, steroid, tar, sulphur and artificial colouring and its fragrance is allergen free. Psorioderm® SENSITIVE product family has won the Hungarian Quality Product Award in 2013!

Psorioderm® SENSITIVE Cream SENSITIVE Cream is a suitable daily skin care both for babies’, children’s and adults’ suffering from extra dry, eczematous, atopic skin. Above 20 kind of natural ingredients it contains extra jojoba oil, honey extracts, shea butter and Vitamin E. Its natural ingredients care and soothe the dry, sensitive and irritated skin and im-prove its comfort feeling. The SENSITIVE Cream is salicylic acid free, and can be used for babies, children and adult with salicylic acid-intolerance in case of psoriatic and seborrhoeic skin.

Application: SENSITIVE Cream can be used after the daily body wash, but for the best result use it several times a day on the most affected areas. Apply it liberally, and then wait a few minutes for complete absorption. Externally applied.

Ingredients (INCI): Aqua, Propylene Glycol, Butyrospermum Parkii (Shea) Butter, Cetearyl Alcohol, Borago Officinalis Seed Oil, Isopropyl Myristate, Polyglyceryl-3 Me thylglucose Distearate, Glycerin, PEG 40 Hydrogenated Castor Oil, Stearic Acid, Urea, Ribes Nigrum Oil, Olea Europaea Oil, Panthenol, Mel, Cocos Nucifera Oil, Lanolin, Theobroma Cacao Butter, Maris Sal, Triticum Vulgare Germ Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Phenethyl Alcohol, Dimethicone, Tocopheryl Acetate, Persea Gratissima Oil, Caprylyl Glycol, Aloe Barbadensis Leaf Extract, Parfume, Lavandula Angustifolia Oil, Bisabolol, Calendula Officinalis Extract, Polysorbate 80, Avena Sativa Straw Extract, Zeolite, Helianthus Annuus Seed Oil, Tocopherol, Glyceryl Linoleate, Beta-sitosterol, Squalane

Psorioderm® SENSITIVE Body lotionSENSITIVE Body lotion is a whole body care for babies’, children’s and adults’ with dry, eczematous, atopic skin. After daily bath it helps to replace the missing subcutaneous fats of the skin, soothes and nourishes the skin from head to toe. Its main ingredients are jojoba, honey extract, shea butter and Vitamin E but contain other twenty natural herbal extracts, oils, vitamins, minerals that strengthen each others effect. The SENSI-TIVE Body lotion is salicylic acid free, and can be used for babies, children and adult with salicylic acid-in-tolerance in case of psoriatic and seborrhoeic skin.

Application: You can use after the daily body wash on the whole body. To achieve the most effective impact regular daily application is recommended. Apply it liberally, and then wait a few minutes for complete ab-sorption. Externally applied.

Ingredients (INCI): Aqua, Propylene Glycol, Isopropyl Myristate, Butyrospermum Parkii Butter, Cetearyl Alcohol, PEG-40 Hydrogenated Castor Oil, Polyglyceryl-3 Methylglucose Distearate, Stearic Acid, Urea, Co-cos Nucifera Oil, Olea Europaea Oil, Ribes Nigrum Oil, Simmondsia Chinensis Oil, Mel, Borago Officinalis Seed Oil, Glycerin, Lanolin, Maris Sal, Theobroma Cacao Butter, Panthenol, Phenethyl Alcohol, Carbomer, Dimethicone, Persea Gratissima Oil, Tocopheryl Acetate, Triticum Vulgare Germ Oil, Caprylyl Glycol, So-dium hydroxide, Aloe Barbadensis Leaf Extract, Bisabolol, Lavandula Angustifolia Oil, Parfume, Calendula Officinalis Extract, Avena Sativa Straw Extract, BHT, Zeolite, Polysorbate 80.

Sensitive, as we like it!

250 ml

www.psorioderm.com

50 ml

39

Sensitive, as we like it!

Psorioderm® SENSITIVE Shampoo

SENSITIVE Shampoo is a gentle nourishing shampoo for sensitive, injured, cracked scalp for babies’ chil-dren’s and adults’. Effectively helps to replace the missing subcutaneous fats of the skin, to provide comfort of the scalp and prevent to get the scalp too dry. It does not help in peeling (Psorioderm® Shampoo does), but helps to regenerate the skin on the head. It contains selected natural ingredients, vitamins, trace elements with added extra jojoba, honey extract, shea butter and Vitamin E.

Application:Use SENSITIVE Shampoo twice or three times per week, or every day. Leave the foam on the scalp for five minutes, then rinse thoroughly to properly rinse out the herbal oils. The hair will be easy to comb. Externally applied. For vulnerable seborrhoeic scalp mix its usage with Psorioderm® Shampoo.

Ingredients (INCI): Aqua, Disodium Cocoamphodiacetate, Propylene Glycol, Cocamidopropyl Betaine, Sodi-um Lauroyl Sarcosinate, Laureth-2, Glycerin, PEG-90 Glyceryl Isostearate, Simmondsia Chinensis (Jojoba) Seed Oil, Butyrospermum Parkii (Shea) Butter, Aloe Barbadensis Leaf Extract, Melaleuca Alternifolia Leaf Oil, Avena Sativa Straw Extract, Mel, Tocopherol, Lavandula Angustifolia Oil, Bisabolol, Panthenol, Maris Sal, Helianthus Annuus Seed Oil, Beta-Sitosterol, Squalane, Disodium EDTA, DMDM Hydantoin, Iodopropynyl Butylcarbamate, Glyceryl Linoleate, PEG-8, Lactic acid, Parfume.

Psorioderm® SENSITIVE Shower gel SENSITIVE Shower gel is a gentle daily hygiene care both for babies’, children’s and adults’ with dry, eczem-atous, atopic skin. It moisturises the skin with many herbal agents and with the extra jojoba, honey extracts, shea butter and Vitamin E. It gently cleans the skin and its moisture content helps to nourish the dry, dehy-drated skin while having bath. The SENSITIVE Shower Gel is salicylic acid free, and can be used for babies, children and adult with salicylic acid-intolerance in case of psoriatic and seborrhoeic skin.

Application:Gently rub the SENSITIVE Shower gel on the vet skin during daily body wash, then after the bath rinse the skin. Externally applied.

Ingredients (INCI): Aqua, Disodium Cocoamphodiacetate, Propylene Glycol, Cocamidopropyl Betaine, So-dium Lauroyl Sarcosinate, Laureth-2, Glycerin, PEG-90 Glyceryl Isostearate, Mel, Simmondsia Chinensis Seed Oil, Butyrospermum Parkii (Shea) Butter, Aloe Barbadensis Leaf Extract, Melaleuca Alternifolia Leaf Oil, Avena Sativa Straw Extract, Helianthus Annuus Seed Oil, Tocopherol, Panthenol, Bisabolol, Maris Sal, Lavandula Angustifolia Oil, Lactic Acid, PEG-8, Beta-Sitosterol, Squalane, Glyceryl Linoleate, Disodium EDTA, DMDM Hydantoin, Iodopropynyl Butylcarbamate, Parfume.

250 ml

250 ml

www.psorioderm.com

The regular usage from had to toe of all 4 products has a strong synergic effect.

RECOMMENDED FOR WEEKLY USAGE

Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7

Sensitive Cream

Sensitive Body Balm

Sensitive Shampoo

Sensitive Shower gel

RECOMMENDED FOR WEEKLY USAGE

Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7

Cream

Body Balm

Shampoo

Shower gel

40

41

Naturalingredients

42

Aloe VeraAloe barbadensis

The scope of the use is very significant, thanks to its agents it is anti-inflammatory, regenerative, antibacterial and anti-fungal, in our products these effects are highlighted. Components: 12 kinds of vitamins (including A, E, C, vita-min B complex); trace elements: iron, copper, manganese, magnesium, chromium, zinc; minerals: calcium, phosphorus, potassium, 18 kinds of amino acids (almost all the essential amino acids and secondary). Furthermore, enzymes, sapon-ins, polysaccharides, pekrin, nucleic acids, phosphoric acids. Aloe vera extract is widely used in cosmetics and alternative medicine, it has soothing-, rejuvenating-, cell regenerat-ing-, and immune-boosting effects.

Curative power:

Aloe vera is used for healing since ancient times. Thanks to the successfully use in myriad diseases, skin disorders and digestive problems, it has thousands of years career. Now-adays it is grown in many countries of the world, where the climate is suitable for open field rearing. It belongs to the succulent plants. In the . VIII. th Hungarian Pharmacopoeia book its offical name is Aloe barbadensis.

Characterization:

Aloe Vera is a perennial plant, its flowers are yellow. Fleshy, succulent, lance-shaped leaves grow to 50 cm, the height of the plant is 120 cm. Only the leaves are used for medici-nal purposes; the parts of the leaves are utilized for different purposes. The viscous, jelly-like sap - the Aloe vera is most often identified by it – this is the gel from inside part of the leaves. In the leaf structure, among the outermost layers and the gel, you can find a yellowish, bitter-tasting juice. By dry-ing this part, you can get the Aloe latex. Commercially it is marked as Aloe hepatica or Aloe barbadensis. (The last one is not the same with Aloe barbadensis Mill).

Enzymes are essential for the body: they play important role in the nutrient absorption and detoxification processes. The active ingredients of aloe may reduce the side effects of drugs, strengthen the immune system and help the body in cleaning. Aloe has mostly anti-inflammatory, anti-fungal, antibiotic and regenerating effects; the plant has high en-zyme containt. In cosmetic compositions you can find the Aloe vera and Aloe barbadensis. Probably the aloin A-gly-coprotein is responsible for the anti-inflammatory effect. It is really good in epithelizing, wound-healing in the case of chronic venous insufficiency ulcers; also good in radiation dermatitis treatment. Thanks to the anti-bacterial, anti-vi-ral effect, it is used for the clinical appearance of the large plaque psoriasis vulgaris.

Components:

112 kinds of vitamins (including A, E, C, vitamin B com-plex); trace elements: iron, copper, manganese, magnesium, chromium, zinc; minerals: calcium, phosphorus, potassium, 18 kinds of amino acids (almost all the essential amino acids and secondary). Furthermore, enzymes, saponins, polysac-charides, pekrin, nucleic acids, phosphoric acids.

Effect:Under the outer membrane of the Aloe skin tissue, it contains aloin, which has mild purgative and emetic effects. This part of the plant is utilized in pharmaceuticals. Aloe has mostly anti-inflammatory, anti-fungal, antibiotic and regenerating effects; the plant has high enzyme containt.

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It nourishes the dry, mature skin; enhances the cell growth. It has high content of vitamins A and E, but also it is rich in unsaturated fatty acids, vitamin B2, D, and K. You can find potassium, phosphorus, iron, sodium, calcium and mag-nesium as well. It has beneficial effects on arthritis (joint) pain. Avocado oil contains also phyto proteins, fatty acids, and glucose. The avocado oil is very well absorbed, deeply moisturize the skin. Thanks to the high vitamin A and E con-tents, significant results can be achieved in the treatment of eczema and psoriasis.

AvocadoPersea gratissima

Therapeutic effects:

The avocado enhances the growth of skin and hair cells. It is rich in vitamin B2, D, A, E, K, and potassium. Avocado oil contains also phyto proteins, fatty acids, and glucose. The avocado oil is very well absorbed, deeply moisturise the skin. Protects against the harmful effects of UV rays. It relieves the symptoms of eczema and other chronic skin dis-eases. The avocado nourishes the dry, mature skin. Thanks to the high vitamin A and E contents, significant results can be achieved in the treatment of eczema and psoriasis. It has beneficial effects on arthritis (joint) pain as well.

Characterization:The avocado is an ancient domesticated plant, the Indians of Central America grown for thousands of years. A highly nutritious fruit contains a lot of protein and oil (fat content of about 25%) is consumed raw. The cooked avocados are bitter, the unripe fruits are considered toxic. After the harvest the fruits should be stored for one or two weeks, it allows the shell to the low pressure. You need to cut the crop for eat-ing, the stone core should be removed; you can sprinkle the soft fruit with salt and pepper, lemon or vinegar drops can be added as well; other spiced is also possible, then spoon from the skin. Especially popular the guacamole, a spicy dish, you can pure or dice the fruit with onion, garlic, a drop of olive oil, lemon or lime, pepper, and with chilli peppers or Tabasco seasoned and used as a sauce or salad.

From the ripe fruit is made well-shelf oil contains a lot of vi-tamins A, B1, B2, C, and vitamin E, which is used in cosmet-ics and dietary purposes. The milky sap of the stone change its colour to the red in contact with air; that is why the Indi-ans used it as ink, textile ink. The beautiful, reddish-brown wood of the avocado is good for building, furniture making, lathe work and woodcarvings. It has long been known as an aphrodisiac, due to probably not as active ingredients, but to the special exterior of the fruit.Thanks to its high oil content, it is well suited for dry skin care. Generally, it is used for the sensitive skin. Helps in the treatment and prevention of eczema symptoms. It affect ben-eficial to arthritis (joint) pain, reduce cholesterol. From the egg size stone they make oil like olive oil by cold press. In the cosmetics industry it is preferred because of nourishing car of dry and aging skin. From the core, medical syrup is made for rheumatic pains.

Effect:It assists in the treatment of eczema prevention and reducing the cholesterol levels. From the stone, medical syrup is pro-duced for relieve rheumatic pain. The avocado oil nourishes the dry, aging skin. Thanks to its high vitamin A and E, it is good for treatment of eczema. The avocado oil content un-saturated fatty acids is rich in vitamin B, C, E and A. The ripe fruits contain potassium, phosphorus, iron, sodium, calcium, and magnesium. The avocados with the high oil content, is excellent care for dry skin. Generally, it is used for sensi-tive skin types. It assists in the treatment of eczema pre-vention.

Pinene, camphene and terpineol containing essential oil, in-vert sugar, rosin, juniperin glycosidic tannins, juniperin acid and other organic acids, flavone glycoside, wax pectin; the fresh plant contains vitamin C. In juniper crop the ingredi-ents of the essential oil are the alpha-and beta-pinene.

The therapeutic effects of the plant:

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Reduces joint inflammation, it has pain killer effect. Pro-tect and care the skin; its refreshing, invigorating ingredients help the skin blood circulation. Includes: Pinene, camphene and terpineol containing essential oil, invert sugar, rosin, juniperin glycosidic tannins, juniperin acid and other organic acids, flavone glycoside, wax pectin.

JuniperJuniperus communis

The ingredients of the plant:

These are in the cone berries. You can use both the fresh or dry form; end of the summer picked berries can be dried on muslin scarf. Internally, bladder infections, rheumatism and kidney infections are treated with it. Its tea is diuretic, antiseptic and has detoxifying effect. Its oil is not only used as aromatherapy oil, but also excellent massage oil, relieves joint and muscle pain. In the kitchen the crushed berries are usually used for spiced meat. In Slovakia the famous liquor, Borovicska is made from it, also paint is made from it. In the Hungarian Pharmacopoeia and in the European Pharma-copoeia its name is Junipero galbulus, drug raw material. In herb tea it has diuretic, digestive, gall and kidney stones sol-vent effect.It has excellent sweaty effect, is good for rheumatic com-plaints. Used against urinary and as a carminative, as an appetite stimulant, gall and kidney stones solvent, catarrhal diseases, gout and rheumatoid arthritis as well. The jam is prepared from the berry is consumed for stimulate the all and kidney, with other herbs. Good to know! Not recommended to consume large quantities during pregnancy! Kidney dis-ease patients must also take care the consumption, due to the strong kidney irritant. You have to pay attention when using it as a diuretic due to its irritating effect on the kidneys, qual-ified specialist must supervise the consumption in this case.Juniper has antiseptic and astringent properties which explains why it has been used to treat acne and other skin blemishes. It has also been used in combination with other herbs to treat psoriasis affecting the scalp.

Interesting:

As a spice you can use it as fresh or dried, whole or ground – it is excellent especially for game, but for sauces, mari-nades also, even for smoke-meat. Due to the pleasant smell, it is mayor component of the meat sauces and meat smoking products. The grilled meats get delicious aromatic flavour of juniper smoke . The whole or halves berries should be re-moved before serving the food. Used to give flavour in vege-table dishes, salads, sauerkraut, marinated fish and ham soak as well. Made from it: jam and juniperus liquor, and used in gin and jenever for seasoning. From the hot, sweet - bitter, juicy, very aromatic flavour berry is distilled the juniper oil, what is the basic of spice and is liquor essence. Its oil and the green parts remaining after the distillation, the coal tar was used in ancient Egypt in the embalming agent - the oil was for healing also. Nowadays, it is raw material of the in-sect repellents and perfumery.

It is rich in vitamins B, E and K, pro-vitamins A and D, min-erals (potassium, phosphorus, magnesium), enzymes and lec-ithin. In the body the pro-vitamin A connects with the cold-pressed wheat germ oil, and transform to active vitamin A. Due to its ingredients, it is the most valuable physiologically oil of the diet.

The pure wheat germ oil provides the necessary vitamin E and all the nutrients coefficients of the vitamin for the human body. It is rich in polyunsaturated fatty acids. At the same time the wheat grass detoxifies and – replacing the missing nutrition - increases the energy levels. It has almost as many vitamins as in the citrus fruits. It has immune strengthening properties. Used for absorption problems, musculoskeletal complaints against. It has strongly alkalizing effect. It con-tains seventeen kinds of amino acids, the body cannot pro-duce eight of them. It is important to take amino acids, as their absence can cause allergic reactions, impaired diges-tion, the immune system is weakened, premature aging can occur. Its high chlorophyll content helps in anaemia, improve blood circulation, oxygenation of cells and tissues.

It is vitamin A source, but its vitamin B and E content is sig-nificant, its potassium, magnesium and calcium content is high. Its enzyme content is unique, there is extremely lots of lipolytic lipase; the protease of the protein and starch me-tabolism, as well amilas; the transhydrogenase, which helps to protect the heart muscles; super-oxiddismutas (SOD) en-zyme is anti-inflammatory, slows down the aging of cells and protects our body from the radiation protection.

The therapeutic effects:Wheat germ oil benefits skin conditions like psoriasis and eczema. It works effectively to heal burns and skin ulcers. As an external application it is very helpful for dry skin. Wheat germ oil is beneficial for the general health of the skin as it improves circulation of blood in the skin when used external-ly. It also helps the skin cells that may have been damaged due to the scorching heat of the sun. It also fights off condi-tions like dermatitis and reduces scarring.

Components:

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Wheat germ oil contains linoleic acid and linolenic acid (5%) which are precursors of the omega-6 and omega-3 es-sential fatty acid. Its beneficial effects thanked to vitamin E, octacosanol and essential fatty acid content. This component gives energy and vitality, renews the skin cells, nourishes the dry skin. It is rich in vitamins B, E and K, pro-vitamins A and D, minerals (potassium, phosphorus, magnesium), enzymes and lecithin.

Wheat Germ Oil

Octacosanol

Beneficial properties:

Protects the heart and blood circulation caused by the over-load damage. Vitamin E slow down the premature aging pro-cess. The skin gets lots of benefits from it as cares the tissues, the skin would be smooth and supple, and stimulates the cell renewal. Wheat germ oil contains linoleic acid and linolenic acid (5%) which are precursors of the omega-6 and omega-3 essential fatty acid. These essential fatty acids are beneficial for the heart, improves cardiac function.Its beneficial effects thanked to vitamin E, octacosanol and essential fatty acid content. Several mechanisms have been raised to show how the octacosanol affects on the stamina and strength. Octacosanol may increase the efficiency of the

transmission of nerve impulses; or improves the oxygen de-livery and uptake. In the recent years discovered polycosanol is a natural substance, a mixture of concentrated fatty alco-hol; including octacosanol also, as well the half-dozen dif-ferent others, like the triacontanol and hexacosanol which are typically extracted from sugar cane syrup or beeswax. Wheat germ can be consumed as a cereal, or for baking bread, or an-ytime you want to get fresh nutrients. The accessories manu-facturers offer wheat germ powder and concentrate.

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The seed oil relieves the allergy symptoms. The plant is one of the most significant source of Vitamin C, although it contains in higher amounts vitamin E, B1 and B2, carotene, potassium and iron. Buds of the plant extracts can effec-tively relieve the chronic skin irritation and symptoms of the exfoliation. It is significant the cobalt, rubidium, seleni-um, manganese, bromine, copper, zinc, potassium, magnesi-um, phosphorus, iron, nickel, calcium and sulphur content. These elements are organic material, the body can use them easily.

BlackCurrantRibes nigrum

High Vitamin C content!Black-currants has one of the highest vitamin C content of the berries, as well as it has greater amount of vitamin E and B, carotene, potassium and iron. The mature berries are rich in the antioxidant, free radical scavenging, anti-tumor col-our materials. Particular, you can find a lot of anthocyanins, flavonoids and poly-phenols.In 100 grams of black currant you can find more than 500 mg of anthocyanin derivatives only (cyanidin, delphinidin, coumaric etc.), and not mentioned the rest of the antioxi-dants. In this respect, it is much better then the other red berry fruits. It is full of carotene, vitamin B1, B2, and E and of course vitamin C. In 100 g of fruit you can find around 130-170 mg of vitamin C. Just in hip you could find more vitamin C. The extract of black currant buds are extremely effective in relieving the symptoms of chronic skin irritation and scaly (seborrhoeic dermatitis, atopic dermatitis, and pso-riasis). In addition to the local application, its high content of gamma-linolan acid is effective emollient, moisturiser, reduces hyperaemia and harmonies the cellular function. Laboratory experiments show that it strengthens the water keep ability of the skin; prevents the excessive evaporation through the skin and increases the hydration and elasticity of the skin.

High mineral content!It is shocking how wide range of minerals you can find in it! It has significant cobalt, rubidium, selenium, manganese, bromine, copper, zinc, potassium, magnesium, phosphorus, iron, nickel, calcium and sulphur content also. These ele-ments

are present as organic material, that can be processed by the body easily. The materials in black currants play a significant role in the metabolism of cells, that is why it is recommended as health developer, immune system tonic. Some researchers believe in the treatment of anti Candida fungal troubles can be achieved with good results.

Interesting:Its active ingredients are built up from trace elements, flavonoids, volatile oil , tannin , rutin, vitamin B, C and P. Well known physiological effects are diuretic, mild blood pressure, gout and rheumatic complaints soothing, cleansing the blood and sweat effect; that is why it is used for bladder, kidney and prostate diseases, for relief symptoms; also good for, rheumatism and to reduce blood pressure. In this way the body has faster fat burn, body weight can reduce easier. The mineral salts of the black currant neutralize the acidic degradation products, and facilitate better heart muscle con-traction. During the burn of the easily digestible sugars and organic acids, the body would be more alkalise, at the same time they burn a lot of the decomposition product of the met-abolic. Thanks to its high content of vitamin C helps to pro-tect against the flu, to strengthen the immune system, and to overcome fatigue. It protects the cells from the cancerous processes. Thanks to its iron, manganese and copper con-tains. With this excellent natural medicine, the women and children’s iron deficiency anaemia can be solved. Its vitamin B content has neural-protective effect.Used for: Auto-immune disorders including lupus, ecze-ma, psoriasis, other skin problems; hair problems, and inflammatory disorders.

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Dead sea saltThe Dead Sea has the world's highest - 32% of mineral con-tent, which included: magnesium, potassium, calcium, so-dium and chloride, bromide, iodide. Through the skin they work off to the cells, they exert beneficial effect in the joints and muscles, relieve the dry skin complaints.

The benefits of dead sea mineral salts

Most of the items effect in the body cells linked to the en-zymes. Our body needs wide variety of mineral elements some more others in small amounts. The elements together are responsible for the development of natural pH value of the skin; for the normal cell-operation, and for the metabolic processes. The Dead Sea salt, black mud and products made from them are rich in these elements; through the dermal skin they reach the cells, joints, muscles and they can effect.

The key elements, trace elements:magnesium, calcium, potassium, sodium , strontium, lithium chloride, bromide, iodide, sulfate, carbonate , kaloans, boti-tans, zinc, cadmium, copper, manganese, iron, cobalt, nickel, barium, molybdenum, boron, rubidium.

Magnesium: important for the structural and metabolism regulatory components of the skin; with activator enzymes it helps to stimulate the cell metabolism. In the absence of magnesium the aging process of the skin is faster.

Potassium: plays role in the conduction, and muscle con-traction; it helps to regulate osmosis and water balance in the skin and in other tissues.

Calcium: Essential for development of the nails, teeth and healthy bones. It is important in metabolism, in defense, in treating injuries and in preventing infections. It strengthens the cell membrane;and major in the muscle function.

Sodium and chlorides: they form the normal osmotic con-ditions of the cells, result the water retention of the cells. The acid-base balance plays a role in maintaining these two elements. Sodium effects on the muscles activated.

Bromide: it can relax the muscles and nerves, promotes the natural regenerative and protective processes. It cures the skin abnormalities.

Iodide: an important component of normal metabolism, it is essential important for the production of thyroxine hormone to regulating the cell's energy.

The Dead Sea salt bath is useful in many other skin diseases (atopic dermatitis, acne, cellulite, dry skin, wrinkling) and in other state (rheumatic diseases, asthma and other respiratory diseases, uveitis, i.e. the inflammation of the eye's vitreous body, hypertension, ischemic heart disease, and intestinal inflammations).

What is special about the dead sea salt?

The Dead Sea is located 420 meters below the sea level, the lowest land-based point of the world. The Jordan River and other natural mineral sources feed its water. As situated in the middle of the desert, far away from big cities and industrial districts, so it is free from the harmful effects of the environ-ment.

The Dead Sea has the highest salt concentration in the earth, four times higher than in other seas. Every sea wa-ter contains magnesium sulfate and sodium chloride. The Dead Sea contains 10 times more chloride and 40 times more magnesium than any other sea waters, and its bromine con-centration is higher, then any other have. These salts without drying out the skin; clean the excess fat and the dead cells from the skin. The natural minerals get into your skin. The Dead Sea salt improves the blood circulation; invigorate the skin and give a beautiful view.

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Jojoba OilSimmondsiaChinensis Oil

The Indians already knew the jojoba oil, extracted from the nut seed of the jojoba bush. It was used as a medicine to disinfect wounds, for skin and hair care, and to protect the skin from the sunshine. This noble oil is the most precious and tolerable natural cosmetics. It is also deal as a carrier for essential oils.

In the Sonoran and Mojave deserts jojoba (Simmondsia chinensis) is the typical plant of the sparse vegetation. Ev-ergreen shrub, which does not grow taller, then 1-2 meters, but it has bulky and dense crown. From the small, greenish flowers 1-2 cm big crops grow, which are food for rodents and birds. Very undemanding plant that grows anywhere, that is why at so many places it is installed to prevent deser-tification. Its biggest value is gold -pressed oil from the crop. Actually from chemically side it is not oil, as no fatty acid, but especially long-chain esters built it up. So the jojoba oil is actually a liquid wax. Thanks to this property, it does not go rancid, but conserves in the same status during years.

The use of jojoba oil, why do we use it in Psorioderm products?

Its speciality that its wax are very similar to human skin tallow. It contains a lot of vitamins, primarily vitamin E. It is anti-allergic, good for any skin type, but is strongly recom-mended for acne-prone skin. It has significant antibac-terial effect. It helps to keep and protect the hair structure, it is often ingredient of hair care products. It increases the elasticity of the skin, for facial skin care can be used also. The Jojoba oil enhances the defends line of the skin, binds the moisture in the epidermis.

The Jojoba oil moisturises the skin. As it is a wax and not oil, it does not mark the skin oily. Yet it provides the fatty ingredients that are necessary to prevent the water loss in the skin. Excellent treatment for dry, aging and oily skin.

Jojoba oil is perfect strengthens the skin's protection function, binds the moisture in the epidermis, increasing its flexibility. Notable property that it undermines function of certain micro-organisms (e.g., Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans), it blocks the bacterial

what play the role in the development of acne as well. That is why it is important component of the creams for acne-prone skin. In addition, all skin types can benefit from jojoba-con-taining creams, excellent raw material for the eye area nurs-es, hair care products as well. People with sensitive skin can use it also; it improves elasticity of the mature, dry skin.

Main applications:For acne skin; it has antibacterial effect, increases the skin's resistance, adjusting the fat production. It is fungicide, inhi-bits proliferation of several species of fungi (including candi-da). For dry skin care it is excellent, enhances skin elasticity, sets the ideal functioning. It helps to keep and protect the hair structure. Jojoba Oil, so pure, hypo-allergenic, and effec-tive, is used in the treatment of skin problems such as acne, psoriasis, and neurodermatitis.

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Cocoa ButterTheobromaCacao butter

Cocoa butter is an edible natural fat obtained from cocoa beans during the chocolate and cocoa production. It has mildly chocolate -like flavour and aroma. In the white choc-olate, this is the only cocoa component. Cocoa butter occurs in α , γ , β ' and β crystal forms, with a melting point of 17 , 23 , 26, and 35-37 ° C. During the chocolate production β crystal form is generally used because of its high melting point. It is one of the most stable, highly concentrated fats, what melts at body temperature , and immediately absorbs into the dermis. The cocoa butter has a high content of vitamin E. For centuries people used it to keep the skin's softness with sustained hydration. Its poly-phenols traverse the free radi-cals to evolve; cocoa butter has sunscreen effect: SPF 5-7; and has a wound healing effect, for eczema and psoriasis cur-ing is recommended.

Unique fatty acid structure!As the key values of the cocoa butter is the unique fatty acid structure and the crystalline structure; also it is hard to find reliable natural product on the market; that is why mainly the refined version is used. The cocoa butter is solid, hard tex-ture fat at room temperature; on 32-36 ° C it begins to melt away. Due to this unique feature allows to be the essential

ingredients of chocolate production (as part of the cocoa paste and as an additive). The cocoa butter contains most-ly stearic acid, oleic acid, palmitic acid and linoleic acid, in addition you can find also carotenoids in it. Approximately it includes only 0.4% of ingredients which are not sapon-ifiable. This hard texture fat is perfect for increasing of the emulsion consistency, but as it has specifically lubricating and film forming effect, that is why it is used primarily for dry skin care products.

Specific crystalline structure!

Thanks to the particular crystalline structure of cocoa but-ter, the products made with it can just reach the last consist-ency only after a few days. Due to the crystal structure of the cocoa butter has heat sensitivity, like shea butter. The warmed up fat phase is available only later to be mixed into it anything. The superheated cocoa butter is no longer able to solidify; the too rapidly cooled one would precipitate in the emulsion. Cocoa butter is not light sensitive; in summer and daily products it is safety to use.

Why do we use a cocoa butter in the Psorio-derm products?It is rich in unsaturated fatty acids, proteins, vitamins, phos-phorus, potassium, manganese, antioxidants. (Vitamin E), The cocoa butter protects against environmental hazards, slow down the aging process of the skin (thanks to the an-tioxidants). It regenerates, moisturiser, softens the damaged skin; The other active ingredient can imbibe deeper with its help.

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Chamomile MatricariaRecutita

Chamomile is almost the most ancient herb to be used in folk medicine and traditional medicine as well. Its healing effect is widespread, in dermatology the soothing, antiseptic, an-ti-inflammatory effects are the weightiest. In our products we use the Alpha Bisabolol (6-Methyl-2-(4-methyl-3-cyclohex-en-1-yl)-5-hepten-2-ol, alpha,4-Dimethyl-alpha-(4 use-me-thyl-3-pentenyl)-3-cyclohexene-1-methanol) of the active ingredients of chamomile. No allergic symptoms develop, no allergic skin reaction can occur!

The Alpha-Bisabolol has anti-inflammatory effect, relieves burning sensation and helps the healing process as well. It gives anti-inflammatory, anti-fungal and soothing properties to the products.

Good to know about the chamomile:Other names: Camomile, Chamomile, Wild Chamomile, Sweet Chamomile, German Chamomile, Hungarian Chamo-mile, Mayweed, Scented Mayweed, Pineapple Weed

What does it inclued?The nest flower of the plant is used for medicinal purpos-es. The drug (Chamomile floss) 0.2 to 0.7% (or can go up to 1.4%) has dark blue colour, contains: sesquiterpene (chamazulene, bisabolol, bisabolol oxides) essential oils, flavonoids (apigenin), glycosides, coumarins (umbelliferont , herniarint), and mucus.

For what is it good?Chamomile is one of the most well-known herbs; you can find this official medicament in most of the state pharmaco-poeia book. Its curative power is multiple, which can be used external and internal as well. The chamomile essential oils are mainly anti-inflammatory agents.

The chamomile steam relieves the symptoms of cough and viral or bacterial respiratory infections; in case of the dis-eases, the immune system forcing effect of the drug reflects well. It is applied in the case of inflammation diseases of the gastrointestinal tract as well. With rinsing the month and the throat can be terminated the inflammation of gums, mouth and throat. It can be used an inhaler for bronchitis.

Camomile rinsing is often the good solution for sores and aphthas in the mouth. Regular consumption of its tea relieves stomach upset, nausea, sickness and symptoms of inflamma-tory bowel disease. Externally, skin diseases, acne (acne), abscesses, wounds and nail bed infections are treated with it. For eye compress it is also suitable.

In gynecology it is used to relieve menstrual cramps and to reduce the parturition time. It is really good as baths, rins-es, steam in the case of abdominal inflammation (vaginitis, hemorrhoids, leg ulcers) as well. Chamomile soothes the col-icky babies; dissolves their spasms.

The camomile oil reduces anxiety in children, and is benefi-cial for hyperactive children as mild "sedative". In homoeop-athy it is used to relieve teething pain in case of intolerance of pain. In cosmetics it is commonly used for skin dryness, itch-ing, anti-inflammatory. It's good for the hair because makes it shiny and soothes the scalp. Children can drink chamomile tea safely. A teething baby's jaw should be rub with camomile oil, where it is necessary.

Good to know!

Sometimes even chamomile can cause an allergic reaction for sensitive patients. Due to the content of sesquiterpene the chamomile contained products can cause allergic skin reac-tions. In that case, do not apply the plant any longer. Espe-cially it is true for the eye infection treatment. If small chil-dren inhaler, please increasingly pay attention to avoid burns.

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Shea ButterButyrospermum

ParkiiThe Shea butter also known as the African shea tree fruits. Its fatty acid content is very rich, also contains a lot of vitamins A, E and D. It can easily absorb, stimulates the skin's own healing ability. Its composition is very similar to the natural protective emulsion composition of the human skin. Thanks to its natural UVB filter effects, you can use it for babies, and it is perfect for all skin types.

During the Shea butter production, no chemical additive, no colouring agent, no heat treatment are used; the end result would be an excellent additive-free, natural skin care cream. It is very important production process, as there is no heat treatment, the product can conserve all the vitamins and nu-trients, helping to prevent all the useful material, what the fruit contains. The basic effect of shea butter that refines the skin, softens the wrinkles and skin irritations, reduces acnes. Thanks to its vitamin E and beta- carotene emollient, it has regenerating effect. Further applications are reduction of the symptoms of eczema and psoriasis . Due to the natural ingre-dients of the shea butter, it can be great alone or part of any natural cosmetics recipes for care about dry, neurodermatitis, eczema skin. It moisturises, soothes, regenerates the skin and has anti-inflammatory effects.

What does the shea butter contain?

Its natural herbal ingredients, dissolved alcohol, high vita-min A (E, F), essential fatty acids and natural antioxidants, these are very similar in structure to the green tea and the extra virgin olive oil. Thanks to its natural UVB filter effect, you can use it for babies, and for all skin types; it is aller-gy-free, perfectly applicable!

Good to know, some interesting facts:The shea tree (Vitellaria paradoxa) at the age of 20 brings the first, large, plum, stone fruit crops; the plant can live and fructify up through 200 years. You can find them on park-land, woodland savannah’s, where huge trees can grown. The shea tree fructifies during the whole year, but usually there are only one or two harvests per a year.

The crop of the plant is the shea nut, it can have up from 60 to 70% fat content. The inside part of the mature fruit should be crashed or finely minced, then mixed with water it should be gently heated over fire. The walnut fat rallies on the top of the water. The result is a medium-hard, yellow and white, sweet, slightly smoky-smelling vegetable fat, shea butter. The particular advantage of this traditional preparation that shea butter can keep the very high vitamin E and F content; as their is no chemicals maceration, it does not contain the chemical residues. The finished shea butter colour, odor and exact composition depends on the harvest time and the land-scape of the origin.In Africa, the shea butter is produced in large amounts. There next to the skin care, they use it in the diet; what is more, as it is flammable, they even light up with it. The pollution-free, unrefined shea butter is filled in barrels and transported to the different parts of the world. One of the largest value of the shea butter that during long time it keeps the same quality without any change, it becomes hardly rancid. In appropri-ate circumstances, it keeps the quality certainly for a year at least, later also only the vitamin content begins to decline slowly. In Africa traditionally shea butter is used for skin care, rheumatism, muscle and joint pains. Thanks to excel-lent properties of the product, it is dominant raw material for the cosmetics industry worldwide (Butyrospermum Parkii).

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The coconut oil is also known as coconut butter (Oleum Cocois), what is made from the dried intestine (copra) of the coconut palm (Cocusnucifera) core. The freshly pressed co-conut oil is white, its taste and smell unusual, but nice. Coco-nut oil might go bad pretty quickly; in this case it tastes and smells waspy and scratched. The coconut oil at room temper-ature is butter - like, and at 24 ° C melts. The coconut oil is mainly used by the population for cooking and baking. The industry uses are for the production of margarine, bakery and confectionery. In small quantities the cosmetic industry uses it for soap production.The coconut fat at room temperature is white, solid, and fat - like material. By heating it turns to liquid, it is called coco-nut oil. Highly saturated oil contains magnesium, calcium, zinc and iron. Due to the medium chain fatty acids it has anti-fungal and antibacterial effects, due to its lauric acid, strengthens the immune system, it is good against the herpes and flu as well.

There are two types of the oil, the filtered (RBD) and the virgin (VCO). In the kitchen and in the cosmetics industry usually the filtered oil is used. The filtering in this case means that they refinery, blanch and deodorized the product. During the RBD process they process the spray dried coconut.They do not refinery the virgin oil so much, and the process happens on lower temperature, and significant difference is that the oil is made from fresh coconuts. On this you can feel better the origin, and thanks to the he lack of chemicals it is healthier. The great advantage of the coconut oil that the ther-mal – tolerance is really good, and under heating conditions its fatty acids are not damaged.

Why do we use coconut oil to Psorio-derm products?Since a long time ago the researchers know the anti-fungal and anti-bacterial effects of the medium-chain fatty acids in the coconut oil. By regular use the body can get the same fatty acids, lauric acid, like it is in the breast milk. The lauric acid has beneficial effects on the immune system. In the body it transform to monolaurin, what is good to destroy the her-pes, influenza and pathogenetic bacterias.

Due to the molecular structure, the coconut oil easily absorbs into the skin. Through the deeper layers of skin, it strength-ens the internal tissues. It can prevent the sun caused dam-ages, or significantly reduce. It prevents the premature skin aging, and provides natural protection from UV rays. It helps to remove the dead epithelial tissues, so the skin would be smoother, softer. After just a few minutes' duration, it gives beautiful, healthy shine and soft, silky feel to the hair.

Wound healing: Coconut oil is used since time immemorial to speed up wound healing. The three identified mechanism be-hind the healing effects: first speeds up the re-epithelialization process, second increases the antioxidant enzyme activity, third stimulates the collagen cross-link mechanism in the repaired tissue. Coconut oil works synergistically with tradi-tional treatments for promoting burn wound healing.Pain killer and antipyretic effects: It is proved that the co-conut oil has anti-inflammatory, painkiller and antipyretic properties as well.

Anti-ulcer effect: It is interestingly, that the coconut milk (which includes the coconut oil components), is more ef-fective than conventional anti-ulcer sucralfate based drugs.

Fungicides: In 2004, 52 isolates of Candida variety were exposed to coconut oil. The best known form of fungus, Candida albicans was the most susceptible to treatment. The researchers remarked: "Coconut oil would be recommended for the treatment of fungal infections as so many number of drugs are resistant for the Candida species."

Coconut OilCocos Nucifera Oil

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Marigold (Calendula officinalis) herb spread throughout Eu-rope. The dried flowers of the plant are used in therapeutics, as the valuable active ingredients are largely concentrated in the yellow flowers. It has Mediterranean origin, it is resident at the Mediterranean coastal and the Western Asia areas. One of the oldest herbs, in our country (Hungary) it is cultivated as ornamental and medicinal plant as well since long time ago. It has epithelizing effect. Externally it can be used for wounds, varicose ailments, ulcers poultice. Internally use can be as tea: antispasmodic, alternative effect. Against eczema either internally or externally applying are both good.

The Marigold essential oil contains (Mentone, izomenton, carvone, terpinene), carotinoids, flavonoids, saponins, free triterpenes (faradiol, taraxaszterol), polysaccharides. Kadiol is its main active ingredient. The marigold is scientifically proven that it is highly active against inflammation of the gallbladder; good anti-spasmodic and disinfectant. Internally it is used for stomach and bladder treatment.

Dermatological use of Marigold:

Recommended for cut, crushed, treat bruised wounds, ab-scesses; in case of purulent wounds it is support treatment next to the medical one. It is also good for care nail bed in-fections; for minor skin cracks (on the edge of the lips, nurs-ing mother's nipples), for treatment of the diaper rash (der-matitis). Also recommended for superficial burns, in case of scalding, chronic wounds, the treatment of leg ulcers; for bedridden patients to prevent and care bedsores; external haemorrhoidal nodes to palliate the itching, burning sensa-tion, reduce the inflammation.

The cosmetics industry likes to use its beneficial properties to make creams, ointments as a raw material. Also recom-mended for palliate the pain of skin rashes and sunburn. Homoeopathic medical practice use it for wound healing, disinfection, bruises treatment. Nursing moms often have inflamed nipples, but by marigold cream the inflamed state can be treated well.

The marigold extract performs the ugliest post-operative scars in record time. It is a really good homoeopathic care for cuts, scrapes, bruises, and after falling purple spots. It can be used successfully even bedsores, bruising, muscle sprains, ulcers, and malignant swellings. Side effects and toxicity are not known. It is perfectly suitable for foot and nail fungus.

It is really good for the skin fungal, bacterial infection related symptoms, beard inflammation, furuncles reduction; its tinc-ture is excellent for post-treatment; its infusion is well used for compress, or as a wash. The fresh plant juice, infusion, tincture, cream speed up the healing and the cleansing of the superficial, crushed, lacerations and bruises.Calendula in this product is a natural, powerful anti-inflam-matory that promotes healing and cell regeneration but does not have the side-effects associated with topical steroids.

MarigoldCalendula Officinalis

Extract

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Lavender is one of the most versatile, the most variously used, delicious smelling medicinal spices and ornamental herbs. The Romans took to Europe, in the ancient times, it was the dominant plant of beauty care. Its Latin name came from lava = wash. There are several ways to use: as body cream, water bath fragrance, soap; even with the dry flowers strewn on the ground was for flavour.

According to folk belief the lavender keeps away the harm-ful, destructive forces and spirits. This strong scent of lav-ender could explain it. A lavender oil is the essential oil of lavender (Lavandula officinalis). It is antibacterial, antispas-modic, anti-inflammatory, calming; it improves the circula-tion, strengthens the immune system, it has analgesic and anti-fungal properties. Its value is signified by the linalyl acetate content (min. 35%). In the 8th Hungarian Pharmaco-poeia its official name is Lavandula aetheroleum.In the folk medicine they use to compress headaches, eye inflammation and barley treatment, and prevention of hair loss. It relieves the spasms. The modern phytotherapy uses it in baths against rheumatic diseases, for making rubbing drugs and massage oil. In the case of migraine headaches the rubbing drug is good; for reducing melancholy or de-pression, its cream or as bath water additive is really good. It speeds up the improvement of the healing wounds. It re-lieves eczema, fungal infections, reduces hair loss, eliminate foot fungus. It soothes the inflamed skin burns.

Thanks to its antifungal and antiseptic effect we use it in the psorioderm prod-ucts.

It heals wounds, cuts, burns, sunburn. Mixed with chamo-mile are used for treatment of eczema. It is effective against head lice, improves circulation, lowers blood pressure. It helps with digestion. Effective against insect bites. As mos-quito and moth-alarm can be used.

Lavender oil can be an effective weapon in the fight against fungi infections. It seems that the essential oils has strong effect on the fungi responsible for common skin and nail infections. Scientists tested the lavender oil and found that it is deadly on several different bacterial tribes responsible for fungi; and on the various types of Candida. The mentioned bacterial are pathogens of skin, hair and nail infections; the Candida varieties can cause mucocutaneous candidiasis, so thrush. Due the anti-fungi and antiseptic effect it is very good for the skin. It is antidote of acne, wrinkles, psoriasis, and other inflammations.

Lavender essential oil:A wonderfully aromatic lavender smells spicy, very pleasant. Leaves or flowers rubbed in our hands smells for a long time. It makes harmony in man, charms everyone with sight and smell; refreshes, regenerates, braces and soothes at the same time.Lavender essential oil is one of oldest drugs used since the ancient time. Even then realized that it is good not only for physical pains, but also effective for the troubled mind. Thanks to its rich application areas can be named the most versatile essential oil. It has beautiful floral fragrance. Next to the tea tree oil, lavender essential oil is only one that can be used directly on the skin in small amount. It can be safely used for toddlers and children.Lavender Oil can help to relieve the pain and itch and pro-vide some stress relief which boosts the immune system helping to heal the lesions. Lavender essential oil contains potent antibacterial and antiseptic agents that help heal burn-ing and itching.

Lavender OilLavandula Angustifo-

lia Oil

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Beeswax is a natural wax produced by honey bees (Apis bee species of the genus). The 12 to 17 days younger work-ers product the beeswax in the form of small flakes from the glands on side of the abdomen. There are 4-7 abdomi-nal holes, where you can find 8 glands in each. The bees-wax is completely transparent, but it turns to white after the bees chew it to plastic. Due to the oils of the pollens and the propolis, the honey would get the final yellow-brownish colour. From the glands, the beeswax flakes are around 3 mm wide and 0.1 mm thick; to have 1 gram of beeswax about 1100 pieces of them should be produced.

The bee use the beeswax to build the honeycomb, where they store honey, pollen and their descendants can bring up here. The ideal temperature for beeswax is 33-36 ° C. Approx-imately the bees need to fly 530,000 miles to product 1 kg of beeswax. The beeswax may be cleaned with hot water, then you can use it for candle manufacture, or as a lubricant, and polished as applicable. With various oils it can be made more fluid.

What does the beeswax contain?The beeswax is a wax from various types of material. Main components are palmitil acid, palmitoleate, hidroxipalmitat, esters form alcohols and oleic acid, and other palmitates. Melting-point is 62-64 ° C. On 85 ° C or higher it changes the colour. Beeswax is approx. 13% of free fatty acids (cerotin acid, melis sin acid), 70% of esters (fatty acids) and solid alcohol compounds, 12-13% of the hydrocarbons. Beeswax is similar to fats, but does not contain any glycerol, branched hydrocarbons protect beeswax from degradation caused by micro-organisms.

The effects of the beeswax on the human body:It has soothing, anti-inflammatory, bactericidal effect, and the skin becomes soften and tight thanks to it improves the recovery ability of the cells; it soothes and prevents the skin from the formation of any inflammation; it improves blood circulation. It has anti-allergic effect, protects against harm-ful UV rays. There is no maximum daily limit to eat; not known any side effects. The beeswax is widely used. Mostly used for cosmetics and pharmaceuticals (use of both of the total 60%) products; as well polishing material (shoe, furni-ture care in) and a modelling wax.

Application areas:Nowadays the beeswax is used more and more often for me-dicinal purposes as well. In the case of respiratory infections, the comb-honey is the most effective; for oral diseases, mix of the wax and propolis is recommend by the naturopath. The heated wax cools down slowly and gradually, you can take advantage of this properties for the swathing. Researches shown the antibiotic and regenerative effects of the wax.White beeswax (E901i) is used for food production, by strong sunlight or hydrogen peroxide bleach the honey to get this colour; sometimes the yellow beeswax (E901ii) may occur. Primarily as a protective cover and as a polishing ma-terial is used, but to get taste (honey flavour) is also possible. Several cheese have honey cover to have longer shelf life, additionally it gives special flavour to the cheese. The pre-historic man used also, in the Lascaux cave have also been found traces of beeswax. The Egyptians used as insulation material for ship construction. The Romans used to make the walls waterproof, therefore the tax was collected in the form of beeswax from the nations. In the Middle Ages it was so precious material that was accepted means of payment.A natural combination of honey, olive oil, and beeswax can provide significant benefit to people suffering from eczema or psoriasis. Perhaps the most significant finding of this study is the ability of the honey mixture to decrease the need for corticosteroids.

Beeswax

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Olive oil is vegetable fat obtained from the crop of the olive tree (Olea europaea); it has greenish-yellow colour, charac-teristic odour, pleasant, sweet taste; on room temperature it is liquid. It is essential ingredient of the Mediterranean cuisine. Nowadays, in Greece, Italy and Spain prepared the most olive oil.

Why do we use olive oil?

The use of olive oil started a long time ago, in 5000 BC al-ready olive oil was pressed. In addition to the dietary it was used for other purposes as well to anoint kings, embellish the princesses' body, moisturiser babies' skin, and smear the bodies.

Beneficial physiological effects:The nut or avocado oil could approach the valuable phys-iological characteristics and beneficial effects of the olive oil; then followed by the cold-pressed sunflower oil and the

other oils; which sweet grape seed oil and apricot kernel oil are highlighted. The therapeutic used olive oil can contain 70-80% mono-unsaturated fatty acid esters, and traces of phytosterols and lecithin. The natural state of olive oil con-tains vital (essential) fatty acids, the vitamins F. These are the building materials of the cell membrane and raw materi-als of important hormone-like substances.

The olive oil contains unsaturated fatty acids, which are essential for the body: linoleic acid, linolenic acid and arachidonic acid (these fatty acids are also called vitamin F). The natural antioxidants of the olive oil are vitamin A, D, E and beta-carotene. Its secondary plant substances are polyphenols and tocopherols. It strengthens the muscle cells and is beneficial in case of rheumatoid arthritis.

Epidemiological studies have shown that the higher con-sumption of unsaturated fatty acids – olive oil is rich in them - reduces the risk of cardiovascular disease. Clinical data confirm that the large amount of consumption of ol-ive oil protects the vascular from arteriosclerosis. It reduc-es the cholesterol, prevents the deposition of cholesterol on the vascular walls. It is anti-inflammatory, antithrombotic, hypotensive and has vasodilating effects in both humans and animals.

The extra virgin olive oil contains: vitamins, lecithin, chlo-rophyll, iodine, monounsaturated and polyunsaturated fatty acids, omega 3 and omega 6 fatty acids.

Ingredient bomb

Thanks to the components of the olive oil, it has beautifying softening effect on the skin. Due to the very high vitamin E content, it has rejuvenating properties. Olive oil contains skin-related components. The olive oleic acid is a component of sebum, which plays an important role in preserving the health of the skin. The olive linoleic acid promotes skin re-generation, this is particularly relevant in changing age.

Linoleic acid protects and nourishes the skin, strengthens the immune system, as well as moisturiser; it inhibits the water loss of the deep layers. Therefore, olive oil skin care is rec-ommended after tanning and heavy use.

The alphatocopherol found in olive is the most important natural vitamin E. This is most useful antioxidant for the skin, that effect against the aging, wrinkles, wizened skin. Alphatocopherol promotes the formation of skin cells, so the new skin cells can come to the surface faster, thereby it has rejuvenating effect.

OliveOlea Europaea Oil

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Panthenol protects the skin, promotes and speed up the skin regeneration. Thanks to its components, it replaces the oil demand of the skin and it is easy smear able. It also can be used in areas susceptible to dehydration.The dexpanthenol belongs to the group of vitamins B and the major part of the coenzyme A. Coenzyme A plays key role in maintenance of the physiological function of the skin and mucous membrane; if they have any lesion then it is respon-sible for the regeneration. The dexpanthenol is the alcohol analog of pantothenic acid, as in the body itself develops also to pantothenic acid, that is why the effect of the two sub-stances are same. In the VIII. Th Hungarian Pharmacopoeia its official name is Dexpanthenolum. Pantenol is approved by the FDA and the CIR for use in cos-metics, and the Cosmetics Database finds it to be a rating of 1, due to lack of data. It has been shown to be a skin irritant in some studies, but only at high levels of exposure, unlike the concentrations common in beauty products or cosmetics.

For what is panthenol good? For what do you use it?

Panthenol is suitable to regenerate the sunburned skin, pro-motes rejuvenation. After sunbathing the panthenolcontaining foam has cooling effect on the skin. Daily use is also recom-mended, especially after bath for sensitive skin children. The dexpanthenol (pro-vitamin B5) smooths the skin and make it supple, thanks to this effect the skin is protected from the harmful action of the environment. The panthenol forms in the skin cells to pantothenic acid, this compound belongs to the group of vitamin B; and it is indispensable to the and skin formation and regeneration. The panthenol with the ointment base protect the skin, promotes and speed up the regeneration of the problem, irritated skin.

As an ingredient in shampoos and conditioners, Panthenol’s binding properties allow it to coat and seal the hair follicles, lubricating the shaft and making the hair appear shiny. As an ingredient in skin products, Panthenol has been seen to im-prove hydration, reduce itching and inflammation of the skin and accelerate and improve healing of epidermal wounds; it is also often used in sunburn treatment products. According to research, when Panthenol is applied topically, it penetrates into lower skin layers, is absorbed into skin cells and pro-cessed into Pantothenic Acid (commonly known as Vitamin

B5). Because it is absorbed deeply into the skin, it adds es-sential moisture. Panthenol is also considered a potential acne treatment because of its absorption properties that can counteract bacteria and its anti-inflammatory properties.

Panthenol

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Salicylic acid (INN: salicylic acid) (it was named after the Latin name- Salix of the willow, is located in the bark) is a beta-hydroxy acid (C6H4 (OH) CO2H) where the-OH group and the carboxyl group are neighbour.

This is a colourless crystalline organic acid. In water it dis-solves hardly, but in chloroform, ether or alcohol very easily. In synthetic chemistry it is frequent reagent, in the nature it is a plant hormone. During the metabolism of salicin it is synthetized. Best known congener is the acetylsalicylic acid, what is active ingredient of several medicaments. In the VIII.th Hungarian Pharmacopoeia Acidum its official name is salicylicum.

Plant hormoneSalicylic acid is a phytohormone that plays an important role in plant development, in the photosynthesis, in the plant res-piration, in the ion uptake and transport; it has specific effect on the leaves anatomy and on the chloroplasts structure. The salicylic acid is an endogenous signaling molecule in the an-ti-pathogen defense mechanisms of the plants as well.

ApplicationSalicylic acid is an important ingredient in many skin care products and cosmetics. It is used for care about acne, pso-riasis, calluses, corns, keratosis pilaris and warts. It speeds up the peeling of the epidermis, so the sebaceous glands do not clog, and then skin can quickly renew. Due to this ef-fect it is part of several anti-dandruff shampoo. Since 1763 the anti-inflammatory effect of salicylic antipyretic has been known. In high dose it is toxic; the salicylic acid is used in food preservation and in toothpaste. Some people have aller-gy even though from small amount of it.

Salicylic acid is one of the most effective ingredients against acne and blackheads what you can use locally (on the skin and not by oral taken). Similar to the AHA acids as it is chem-ical exfoliation, but as opposite to the AHA it dissolves in not water, but in fat; that is why it can peel within the pores, due to this effect it clean them. Secondly, salicylic acid is anti-in-flammatory, which is also important in the treatment of acne. The salicylic acid is generally used at a concentration of 0.5-2% and the exfoliative effect is the best on 3-4 pH.

InterestingSince ancient times known that the bark of the willow (Salix) is febrifuge and pain killer. Around 400 BC Hippocrates rec-ommended willow leaves for eye diseases and relieve labour pains. The willow leaf and the bark of its wicker should be shoaked in hot water to extract the active ingredients Willow bark contains around 0.6% salicin, but it also includes vari-ous glycosides, catechin tannin, resin, oxalate, and various enzymes. The willow bark infusion was used internally as a drink for bleeding, catarrh, rheumatism, joint pains, gastri-tis and as febrifuge; or externally, for the frozen parts of the body, and haemorrhoidal pains applied.

Edward Stone, English doctor reported first about the its antipyretic effect in 1763 for the members of the Royal So-ciety (Royal Society). 50 febrile patients were treated with willow bark extract, which had the same effective as qui-nine from the Chinese tree (febrifuge, anti-inflammatory, pain-killer alkaloid). In 1806, Napoleon ordered the conti-nental closure and the quinine was not delivered to Europe, so they had to return the application of the willow bark ex-tract. In 1828 Johann Andreas Buchner, the Munich profes-sor pharmacist, extracted a bitter, yellow substance, which he named salicin after the Latin name for (Salix) willow.

Salicylic Acid

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Tea tree oil is one of the most amazing natural, with more than 80 organic constituent, extract scientifically proven medici-nal properties. The main components of tea tree oil (+)-ter-pinen-4-ol (about 40%), α-terpinene (about 20%), terpineol (3-4%), terpineol (3-4%), pinene, myrcene , phellandrene, p-cymene, limonene, 1,8-cineole. The tea tree oil is an ex-cellent antiseptic, use of skin inflammation caused by burns and puncture injuries are very common. Essential for vaginal infections, psoriasis, arthritis symptoms. Perfect for use in other muscle pain and reduce the inflammation of the gums and oral cavity cancers, nasal congestion, rash, sore throat and a variety of fungal infections.

Tea tree essential oil has a long medical history from ancient times. In ancient China already B.C. around 3000 they al-ready recognized the healing power of tea tree on the human tracts. Tea tree oil is a natural pure concentrate, free from any aggregate. Since the discovery of antibacterial effect it is used wide range for disinfectant.

Normally known fact that tea tree oil (Melaleuca alternifolia essential oil) has anti- septic , anti-inflammatory and im-mune-stimulating properties. More, the tea tree oil is a very effective herbal broadband antibiotic, which can be good against not only bacteria but also virus and fungi. Due to the lipid solubility propriety, the essential oil can penetrate the cell membrane and destroying the micro-organisms as directly changes the metabolism. Thanks to the large number of active substances, the resistance effects of the microbial do not occur - in contrast to most of the antibiotics. Due to bactericidal properties, it is part of several skin preparations, like dandruff, oily skin, and anti- acne products. It destroys the disease spread by micro-organisms, bacteria and fungi; it has positive effects on the immune system; its antiseptic effect increases on contact with a bleeding surface. The tea tree oil is great for preventing and care the occurrence of the skin surface fungi. It can be used on intimate areas also!

The tea tree extract cleans deeply the oily or problematic skin and hair. It helps to remove harmful bacteria and make free the hair from fat, the unpleasant effects of air pollu-tion and from the dirt effects of the environment. For a long time ago the tea tree oil is used safely in various cosmetic products, and its positive proprieties are proved by scientific data. Some people are allergic to the oil, and may experience a mild skin reaction during use. The tea tree oil contained products are recommended for oily skin or acne-skinned teenagers.

Why do we use tea tree oil extract?

Widespread use of tea tree oil based on the two interrelat-ed characteristics of the oil: the tea tree oil kills the dis-ease-spreading organisms, bacterial and fungi. The tree oil at the same time positively effects on the human immune system, it helps the defense system of the body to be strong against health-threatening pathogens. For disinfection of the skin injury, the pharmaceutical clean tea tree oil is excel-lent, as it does not burn the wound. Interest discovery that tea tree oil has stronger antiseptic effect connecting with the purulent, bloody wounds. The tea tree oil does not irritate the most sensitive skin either, and it has beneficial for the development, renewal of cells. Sensitive skin patient can use safety the products produced from it is excellent for problem-atic, difficult and allergic skin care.

Tea Tree Essential Oil

Melalecua Alternifo-lia Oil

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The urea, organic compound is dynamite of the carbon-ic acid. Its formula is CO (NH2) 2. Colourless crystalline compound crystallizes in prisms. It dissolves easily in water and alcohol. It is the protein metabolism end-products of the mammalian and human. The body secretes it in the urine, an adult person excretes 25 to 30 g per day. The organic urea is prepared from two inorganic salts: potassium- cyanate and ammonium-sulphate.

Almost in every body fluid you can find it. It is 0.4 percent of the sweat. In the normal males’ and females’ skin you can find about 8 micrograms of urea per cm2.

Why do we use urea in Psorioderm products?

The urea concentration decreases by 50% in the case of the dry-skinned people. If so the scaly skin or neurodermatitis and the mature skinned patients, this loss is even greater. Our products are to give back the lack of quantity of urea into the skin. By the age progresses, the skin lipid-production and water storage capacity of the body reduce. The skin gets drier, harsher and scalier. The fine lines begin to appear. By locally application of a natural moisturiser factors, such as urea, the water storage capacity of the skin increases. The daily mois-turising of the skin top layers makes the skin smoother, finer and better protection against the environment.

In the asymptomatic but clinically dry skin, this quantity can be only 3 micrograms; it can reduce to 1.5 micrograms in the patients’ skin. In the elderly skin you can find extremely low concentrations, also in the eczema or psoriasis patients’ skin.The serious form of urea occurs in atopic dermatitis. As the main component of natural moisturising factors, it helps the other active agents to get into skin areas. It smooths itching and has antibacterial effect, but the most important function is the rehydration of the dermis.

Why to use urea in dermatological pro-ducts?

It is considered as one of the natural moisturising factor of the skin, it intensely affects the water conclusion of the der-mis. In dry skin, this concentration can be reduced by 50%, while in case of atopic eczema the absence of urea can in-crease further. As a result, the skin is less able to absorb and retain moisture; by time it loses more and more water; the skin gets drier, cracked and would be prone to itching, scal-ing, and allergic reactions.

In the recent years urea turned to be one of the most impor-tant agents for skin care. This excellent skin-compatible ma-terial is component of the natural moisturiser factors; by lo-cally use the water storage of the skin can be increased. Does not cause allergic reactions, overdoses is impossible on the traditional way, since urea is a natural product and the skin takes up as much of it as needed for regeneration. By the urea contained product, you can daily moisture the skin top layers, the skin would be smoother, finer and better protected against the environment.

Dermatologists generally recommend at least 3-5% concen-tration in order to meet the best results. In individual cas-es, or in addition to medicaments it can be used at a higher concentration (10%); in facial creams maximum of 5% urea concentration is recommended. On damaged, without dermis areas of the skin, urea contained products may sting.

Urea

A vitamin is an organic compound that is although in small amount, but essential for living. The body is not always able to produce them in sufficient quantity, so via nutrients can get them. Vitamins are not classified by their chemical struc-ture, but by their biochemical activity; therefore one vitamin can be more equivalent effect compounds. The Psorioderm products contain lots of vitamins as constituents of the vege-table oils: vitamin A, provitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12 , vitamin C, vitamin D, vitamin E, vitamin F (essential fatty acids) vitamin K, vitamin P.

VITAMIN A: It plays essential role in the normal sight. For want of it, night blindness or total blindness can occur. Stored in the liver, the stock of the nor-mal, healthy body is large enough, even many years are needed to takes it to empty. In the absence of vitamin A, the skin is drier to touch, the nails are broken, later server symptoms may be occur in associated with sight failing. Consumption of li-ver, cod liver oil, egg yolks, sor-rel, spinach, carrots, yellow fruit we can get.

VITAMIN B1 (TIAMIN): The presence of vitamin B1 is required in several enzyme reactions, for example: carbohydrate metabolism, nerve cell func-tion, heart function. The lack of the vitamin a disease occur, called Beriberi. Dried yeast, whole grain cereals, pork, liver, nuts, legumes contain it.

VITAMIN B2 (RIBOFLAVIN): It plays important role in the cell energy supply and the defense of the skin and mu-cous membranes. Vitamin B2 deficiency causes cracks at the corners of the mouth, skin inflammation. Dairy products, meat, fish, poultry contain vitamin B2.

NIACIN OR NICOTINIC ACID (VITAMIN B3): It is essential vitamin for the body normal metabolism; this orga-nism can produce this vitamin in small quantity. Lack of nia-cin, the pellagra disease occur, its typical symptom is the ton-gue inflammation. You can find the nicotinic acid in yeast, whole grain cereals, pork, liver, legumes, and vegetables.

PANTOTHENIC ACID (VITAMIN B5): Absence condi-tion occurs rarely, as most of the foods contain it. The body needs it widely as it affects the cholesterol levels, and for-mation of blood. Liver, yeast, vegetables contain in larger quantities.

VITAMIN B6 (PRIDOXIN): It plays roles in the protein and fat metabolism, functioning of the nervous system, ma-intaining the healthy skin. Yeast, whole grain cereals, organ meats, liver, legumes contain it.

VITAMIN B12 (CYANOCOBALAMIN): It is responsible for the normal operation of the nerve cells, the proper car-bohydrate metabolism and for the formation of red blood cells. Lack of this vitamin anemia (anemia permiciosa) can occure. Liver, red meat, inside majority, eggs, and dairy pro-ducts contain it.

BIOTIN: It has role in the carbohydrate and fat metabolism. Its absence cannot appear with normal balanced diet. You can find it in liver, offal, eggs, yeast, seeds, nuts, legumes.

VITAMIN C: This vitamin has the widest role in the body. It is responsible for the normal function of the immu-

ne system, the proper physical development, the healthy development of the bones and

connective tissue; the maturation of red blood cell. It is potent antioxidant. Lack of this vitamin, the general con-dition of the body deteriorates; we are more disposed to disease and, in severer cases pyorrhoea may occur, leading to tooth lost. As it is a wa-ter-soluble vitamin, therefore, litt-le le amount is stored in the body,

daily supplementation is required. High content of vitamin C: citrus

fruits, potatoes, peppers, tomatoes, sa-uerkraut.

VITAMIN D: It is the essential vitamin of the normal bone formation and evolution. With its help the

minerals can be built on the bones. Lack of it can cause ab-normal bone growth in infancy and early childhood, rickets may occur. Fish liver, egg yolk include it. Due to sunlight in the skin it can be exposed.

VITAMIN E: One of the best natural antioxidant, it protects and regenerates the liver, it plays role in the hormone produc-tion. Free radicals are formed in the body during the metabo-lic processes, or may get into from external sources (harmful radiation, smoking and a variety of toxic substances), these things destroy the cells, damaging tissue. Antioxidant vita-mins can protect against the harmful effects of free radicals. Next to the vitamin E, vitamin C and beta-carotene have ant-ioxidant activity yet. Vegetable oils, wheat germ, egg yolks, green leafy vegetables, legumes contain it.

FOLIC ACID: It is essentially important to product nor-mal blood formation, and to the amino acid metabolism. The pregnant women need folic acid supplementation in the early in pregnancy, as it is a necessary vitamin for the normal development of the embryo. Lack of it, severe anemia may develop, which begins with the oral mucosal inflammation. You can find a lot of folic acid in fresh leafy vegetables, fru-its, liver, organ meats, and yeast.

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VitaminsAs part of the vegetable oils

62

The zeolites are mainly clay minerals as sodium calcium aluminosilicates. Zeolites have large, hollow, porous spatial structure, like a gardened sponge. By heating the water is removable while the lattice structure does not collapse. Due to the cavities, channels, different molecules and compounds can be stored. Naturally in these cavities you can find most-ly water, what is mostly in absorption, in small amounts of chemically bounded. Due to heating this water can be re-moved from the canals, wells. This zeolite, what lost the wa-ter, it is again able to absorb water again from the air, while its temperature rises a few degrees. Thanks to the size of zeolites pore drains, they are able to bind not only water but also other molecules.

Human consumptionIn the Antiquity the zeolite powder was only used for wound healing, as it can clean the exudate wound and reduce bleed-ing. Its immune system refreshing effect is proven. As a die-tary supplement it has benefits on the intestinal flora. Thanks to its absorbent effects it is added to wound powder as hae-mostatic. Sprinkling vulnerably powder at a time. In soft drinks production is used as additive thanks to its positive ef-fects: flavour tier, micro-nutrients remount, digestive system supporter. NASA also uses for bound the harmful substances and as a dietary supplement in the aerospace industry.

Carrier ingredientIt can be used as carrier ingredient as well. From the natural substances it can transfer many of the components direct-ly into the cells. Its physiological effect is significant. The zeolite forms a tetrahedron-shaped lattice structure. Its ma-terial is silica-alumina-oxide, in the drains negative charged calcium, magnesium, sodium and potassium ions are located. They stabilize and regulate the body's electrolytes. The re-moval of heavy metals is also really good. The 0.4 manome-ters size channels are ideal for the binding and neutralization of the heavy metals and ammonia.

High antioxidant activityThe zeolite powder detoxify the body and help in launching the self-healing mechanism, thanks to its absorption effects on the poisons, and the extraordinary anti-oxidant (free rad-ical removal) property. Due to these benefits the zeolite is very efficient to make stronger the immune system and pre-vent the disease. The life length of the cells increase thanks to these overall effects.

Zeolites- Hot stones -

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Zeolite in diversebiological activities

Immune system regulation:

The activated zeolite plays an important role in regulation ofthe immune system containing a high portion of silica, sili-cates and aluminosilicates act as non-sapecific immunostim-ulators like superantigens.Having antiviral properties, the activated zeolite used local-ly, on the skin, has a therapeuticall application against the herpes virus infection or orally in the cases of adenovirus or enter virus infections. It is to point out that viruses are very small and on nonsocial level, from 65–80 nm for adenovirus-es and enter viruses to 100–200 nm for herpes viruses. Anti-viral effects of the activated zeolite can be explained by in-corporation of virus particles into the pores of such crystals.

Antioxidative effects:

The activated zeolite has very strong antioxidative proper-ties that could affect an oxidative stress in cancer and diabe-tes patients. Additionally, diabetes mellitus patients can use zeolite for the reason of its glucose high absorbance.Free radicals are the main factors of many pathological changes in organisms. It was found that around 90% of var-ious diseases are results of disturbances in a cell function or cell damage caused directly or indirectly by the activity of oxygen free radicals.

Free radicals derived from oxygen have been implicated in numerous pathological processes including inflammation, reperfusion injury, hemorr-hagic shock, autoimmune diseas-es, neurological disorders, diabetes mellitus and cancer.It is confirmed that activated zeolite acts against disease Pso-riasis vulgaris on the base of antioxidative activity. Antiox-idant capacity, activated zeolite demonstrated anticancer ac-tivity in vitro tissue cultures by inhibition of protein kinase B (c-Act) and the induction of expression of tumor suppressor proteins, independently from p53 protein. The blockade of the cell growth has been shown in several cancer cell lines.The effect of the activated zeolite on cell proliferation in vit-ro was studied on several human cell lines. The cell viability was determined using MTT assay (from Sigma) which de-tects dehydrogenase activity in viable cells.

Healing Wounds:

In the wound healing there are five important requirements: moist environment, antimicrobial, non-toxic to human cells, hypoallergenic and continuous debridement. Activat-ed zeolite just follows these requirements having for such a reason favorable effects on the healing process in the next superficial skin wounds:Acute skin problems - mechanical skin damage, thermal burns, abrasions, insect bites, post-operative wound treat-ment, herpes simplex and herpes zoster.Chronic skin problems - various skin infections, allergic reaction, degenerative diseases, neurodermitis, ulcer cruris, decubitus ulcers, psoriasis, etc

Adsorbens:

Zeolites, being the adsorbents, eliminate a number of toxic substances (heavy metal salts, nitrates, nitrites, mycotox-ins, radionuclides, metabolism products) from the organism. Zeolites adhere to pathogenic bacteria; their use in the capac-ity of the matrix of pharmaceutical compositions inhibits the antibiotic (tetracycline, neomycin, framicoin) activity, there-fore they act as detoxicants.

PGST(Psorioderm Ghost Stone Transfer)

What is this PGST?

Special technology, developed by Pezomed Ltd. During

the process, we used a special mixture of the zeolites

stones, and naturale oils. The naturale oil’s active ingre-

dients, and vitamins, and trace elements migrate to the

zeolite crystal structure. Imperceptibly passes through

the cell membrane into the cell

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Whose skin was at risk

Vilmos had made the mistake by terminating daily care when his condition did not worsen any more. He did not know that regular, targeted care is the key for preserving skin health. „I’ve learned the lesson from my own mistake, as I had to start it all over again. And what is more, my untended skin started to crack again and it was painful, so the cream burnt at first. Since then I always take at least the cream with me and use it several times a dayeven when my patches can hardly be seen.”

Now he does not only treat the patches

Vilmos had learnt that though patches appear only on certain parts of the skin, he has to treat the whole skin surface daily with nourishing agents to preserve the health of his skin on other parts. So he uses Psorioderm® even for wash and body care.

FROM HEAD TO TOE EVERY DAY!

I do not have tohide it any more

Psoriasis?

„As a sales rep, my whole life has changednow that I can shake hands without em-barrassment and without noticing fright in the eyes of my partner because of the odd patches.” – says Vilmos Bojti gladly, who suffers from psoriasis on his hand, fo-rearm and under the knee, but gained back his self-confidence by the daily use of Pso-rioderm®.

The most important things for him besideswork are his family and drums, but psori-asis has made his life hard for years. „After struggling for many years, I could not even believe when patches began to fade on my hands and arms after daily, regular skin care.”

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Medical Opinionon Psorioderm® Clinical Study

Additional fact-findings by the principal investigator:

Placebo was need to be similar to Psorioderm® cream pertaining to fragrance, consistence and colour at the request of the Department of Dermatology, University of Debrecen Medical and Health Science Centre. Consequently, most of the ingredients of placebo are the same as Psorioderm® cream.

INGREDIENTS OF PLACEBO (INCI): Aqua Destillata, Zea Mays Germ Oil, Calendula Officinalis, Glycerin, Cocos Nucifera Oil, Cetearyl Alcohol, Stearic Acid, Polysorbate60, Isopropyl Myristate, Sorbitol, Urea, Tocopheryl Acetate, Sodium Lauryl Sulfate, Retinil Acetate, Lactic Acid, Carbomer, So-dium Hydroxide, Imidazolidinyl Ethyl-, Methyl-, Propylparaben, BHT

The ingredients of placebo have peeling, anti-inflammatory, emolliating, fat replacing, skin conditioner and moisturizing effect property as well. Furthermore, placebo also has an ingredient with antioxidant ef-fect. Regular usage of a cream containing only the above mentioned ingredients can alone relief psoriatic skin symptoms. However, the potency of the ingredients of placebo depends on concentration, which is unknown for the principal investigator.

The double-blind study did not show significant difference in effectiveness between Psorioderm® cream (with active ingredients) and placebo, however it apparently revealed that application of Psorioderm® cream led to greater change compared to placebo in every time. Assessment of VAS (Visual Analog Scale), demonstrating subjects’ subjective opinion, decreased significantly. Regarding to the assessment of PGA (Physician’s Global Assessment), according to the investigators’ assessment, PGA decreased significantly at Visit 8.

Overall, daily used Psorioderm® cream can alleviate the psoriatic symptoms. Consequently, Psorioderm® cream may reduce the requirements (application frequency) therefore the side effects of topical steroids, which are the most commonly used topical agents in psoriasis. Thus, Psorioderm® cream can be used to ease psoriatic symptoms and also can improve the patients’ quality of life.Based on the results of Period II (open label study), psoriatic patients’ conditions improved by treatment with routine application of Psorioderm® (with active ingredient) on the whole sur-face of the skin. All observed parameter showed significant improvement.

According to the principal investigator Psorioderm® cream has therapeutic effect.

Principal investigator:Eva Remenyik, M.D., D.Sci., Head of the Department of Dermatology, University of Debrecen Medical and Health Science Centre

INCI: International Nomenclature of Cosmetic Ingredients

CLINICAL STUDY REPORTpsoriasis which does not require biological therapy cream in treatment of mild to

moderate plaque ®Efficacy of Psorioderm I.-II. period

Principal investigator: Eva Remenyik, M.D., D.Sci., Head of the Department of Dermatology, University of Debrecen Medical and HealthScience CentreEthical considerations: The investigational pro-duct is cosmetics. Despite, this study was con-ducted in accordance with GCP (Good ClinicalPractice) guidelines. (Number of Ethics Com-mitte approval: OSTRAT/9714/2010)Objective: To assess the efficacy and safety of Psorioderm® cream partly by placebo-control-led, double-blind, parallel-group, comparativestudy and by continuous routine application of Psorioderm® cream in subjects with mild to mo-derate plaque psoriasis.

SUMMARY OF PERIOD I, II:A kettős vak kezelés hatására a PSI értéke szigIn the double-blind study, PSI (Psoriasis Severity Index) score decreased significantly and con-tinuously by Visit 8 by the treatment both with placebo and also with Psorioderm® cream with active ingredient. Application of Psorioderm® cream led to greater change in PSI compared to placebo. Assessment of VAS (Visual Analog Scale), demonstrating subjects’ subjective opi-nion, decreased significantly. Regarding to the assessment of PGA (Physician’s Global Assess-ment), according to the investigators’ assess-ment,there was no detectable difference between the results of Visit 1 and Visit 2. However, PGA decreased significantly at Visit 8. Overall, da-ily used Psorioderm® cream, can alleviate the psoriatic symptoms. Furthermore, Psorioderm® cream may reduce the requirements (application frequency) therefore the side effects of topical steroids, which are the most commonly used agents in psoriasis.Based on the results of Period II, treatment with routine application of Psorioderm® (with active ingredient) on the whole surface of the skin, all parameter which indicates the improvement of psoriatic patients’ conditions improved signifi-cantly.

APPLIED TREATMENTSPeriod I.: Double blind, placebo-controlled studyActive ingredient: Psorioderm® cream (Aqua Destillata, Propylene Glycol, Isopropyl Myrista-te, Hydrogenated Shea butter, Aloe BarbadensisLeaf Juice, Glycerin, Urea, Ribes Nigrum Seed Oil, Borago Officinalis Seed Oil, Polyglyceryl-3 Methylglucose Distearate, Cetearyl Alcohol, Stearic Acid, Cocos Nucifera, Olea Europaea Fruit Oil, Panthenol, Theobroma Cacao Seed Butter, Lanolin, Hydrogenated Wheat Germ Oil, Persea Gratissima Oil, Dead Sea Salt, Di-methicone, Caprylyl Glycol, Salicylic Acid, To-copheryl Acetate, Calendula Officinalis, PEG-8, Lavandula Angustifolia Oil, Perfume Bianco, Bisabolol, Avena Sativa Straw Extract, Glyceryl Polyacrylate, Zeolite, Butylhydroxytoluol, Cap-rylyl Glycol, Lactic Acid)Placebo: The vehicle of Psorioderm® cream (containing moisturizing skin care products)

Period II.: All subjects apply investigational pro-ducts with active ingredient (Psorioderm® sho-wer gel, Psorioderm® lotion, Psorioderm® cream) to treat their psoriatic plaques every day

PERIOD I.:Method: Placebo-controlled, double-blind studyDuration of study: 10 March 2011 - 10 June 2011

Number of analyzed subjects: 29 subjectsDiagnosis: mild to moderate plaque psoriasis which does not require biological therapyDuration of treatment: 6 weeks

Method:To assess the efficacy, PSI was determined every week. PSI, influenced by the extent of exfolia-tion, skin inflammation and thickness,indicates objectively the severity of the disease (maximum: 24 points) on the analyzed psoriatic area. At Visit 1, Visit 2 and Visit 8 VASand PGA were determined. These parameters indicate the subjects’ and the physicians’ subjec-tive opinion on the course of the disease.

Treatment - Results:In the study, 29 subjects were enrolled of which 27 subjects completed Period I. The mean dura-tion of psoriasis was22.9 years. On the affected skin of subjects, two symmetric areas (approximately 8x15 cm) were analyzed. There had to be a large or severalsmaller psoriatic plaques on the observed area. Each of their size had to be at least 10 cm2 and

they also had to be localized far from eachother. On the enrolment, there was no significant difference between PSI scores of Area 1 (treated with Psorioderm® cream, mean PSI: 15.2,median: 14.00) and Area 2 (treated with placebo, mean PSI: 15.2, median: 12.00) (Figure 3).At the baseline the mean and the median of VAS scores were 5.52 and 5.00, the mean and the me-dian of PGA scores were 3.86 and 4.00,

respectively. Compliance was evaluated by a scale range from 1 to 5 at the end of the study. The subjects agreed to neither sunbathe, noruse tanning devices, nor apply other topical creams with active ingredient during the study.

SUMMARY - CONCLUSION:Overall, Psorioderm® cream using twice daily, can alleviate the psoriatic symptoms. Furthermo-re, Psorioderm® cream may reducethe requirements (application frequency) there-fore the side effects of topical steroids, which are the most commonly used agentsin psoriasis.Application of Psorioderm® cream (Cream 1) leaded to greater change in PSI compare to pla-cebo (Cream 2). Assessment of VAS decreasedsignificantly (p = 0.001) (Figure 4). Regarding to the assessment of PGA, there was no detectable difference between the results of Visit 1and Visit 2, however, it decreased significantly (p = 0.0001) at Visit 8 (Figure 5). According to the investigators’ assessment, the subjects’symptoms tend to decrease on PGA scores (Fi-gure 5 - above) and they experienced significant improvement, as well (VAS) (Figure 4).Treatment with Psorioderm® cream caused more significant changes compared with place-

bo, however, considerable placebo effectwas also revealed.

PERIOD II.:All subjects apply investigational products with active ingredient (Psorioderm® shower gel, Pso-rioderm® lotion, Psorioderm® cream) totreat routinely their psoriatic plaques every day.Duration of study: 28 April 2011 (data of the enrolment of the first subject) - 29 August 2011Number of analyzed subjects: 22 subjects from Period IDiagnosis: mild to moderate plaque psoriasis which does not require biological therapyDuration of treatment: 12 weeks

Method: To assess the efficacy, PSI was deter-mined monthly once more. At Visit 1 and Visit 4 VAS and PGA were determined once again.These parameters indicate the subjects’ and the physicians’ subjective opinion on the course of the disease. DLQI (Dermatology Life QualityIndex) was also determined during Period II.

Treatment - Results: In Period II, 27 subjects were enrolled of which 22 completed the study. All subjects applied investigational productswith active ingredient to treat not only their ana-lyzed psoriatic plaques but the whole body sur-face. Those subjects who completedPeriod I were enrolled in Period II. All investiga-ted parameter indicating that the severity of pso-

riasis improved significantly by the endof the treatment compared with the baseline. VAS score was 3.66 at Visit 1, which decreased significantly (VAS: 2.68, p=0.04) by the endof treatment lasting 3 months. PGA score was 2.81 at the baseline, which decreased (PGA: 2.14, p=0.011) by Visit 4. DLQI was 7.3 at thebaseline, which decreased significantly (DLQI: 3.95, p=0.0003) at the end of treatment. PASI score was determined at the baseline, at thefinal visit and continuously during the treatment, according to study protocol. All of four scores improved continuously: 2.27; 1.91; 1.44;1.03 (p=0.0001).

SUMMARY - CONCLUSION:Based on the results of Period II, treatment with routine application of Psorioderm® (with active ingredient) on the whole surfaceof the skin all parameter which indicates the improvement of psoriatic patients’ conditions improved significantly.Abbreviations : PSI - Psoriasis Severity Index | PGA - Physician’s Global AssessmentVAS - Visual Analog Scale — assessment of sub-jects | DLQI - Dermatology Life Quality Index

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CLINICAL STUDY REPORTEfficacy of Psorioderm® cream in treatment of mild to moderate plaque

psoriasis which does not require biological therapy

SUMMARY

Principal investigator: Eva Remenyik, M.D., D.Sci., Head of the Department of Dermatology, University of Debrecen Me-dical and Health Science CentreEthical considerations: The investigational product is cosmetics. Despite, this study was conducted in accordance with GCP (Good Clinical Practice) guidelines. (Number of Ethics Committe approval: OSTRAT/9714/2010)Objective: To assess the efficacy and safety of Psorioderm® cream partly by placebo-controlled, double-blind, parallel-group, comparative study and by continuous routine application of Psorioderm® cream in subjects with mild to moderate plaque psoriasis.

SUMMARY OF PERIOD I, II:In the double-blind study, PSI (Psoriasis Severity Index) score decreased significantly and continuously by Visit 8 by the treatment both with placebo and also with Psorioderm® cream with active ingredient. Application of Psorioderm® cream led to greater change in PSI compared to placebo. Assessment of VAS (Visual Analog Scale), demonstrating subjects’ subjective opinion, decreased significantly. Regarding to the assessment of PGA (Physician’s Global Assessment), according to the investigators’ assessment, there was no detectable difference between the results of Visit 1 and Visit 2. However, PGA decreased significantly at Visit 8. Overall, daily used Psorioderm® cream, can alleviate the psoriatic symptoms. Furthermore, Pso-rioderm® cream may reduce the requirements (application frequency) therefore the side effects of topical steroids, which are the most commonly used agents in psoriasis. Based on the results of Period II, treatment with routine application of Psorioderm® (with active ingredient) on the whole surface of the skin, all para-meter which indicates the improvement of psoriatic patients’ conditions improved significantly.

APPLIED TREATMENTSPeriod I.: Double blind, placebo-controlled study• Active ingredient: Psorioderm® cream (Aqua Destillata, Propylene Glycol, Isopropyl Myristate, Hydrogenated Shea butter, Aloe Bar-badensis Leaf Juice, Glycerin, Urea, Ribes Nigrum Seed Oil, Borago Officinalis Seed Oil, Polyglyceryl-3 Methylglucose Distearate, Ce-tearyl Alcohol, Stearic Acid, Cocos Nucifera, Olea Europaea Fruit Oil, Panthenol, Theobroma Cacao Seed Butter, Lanolin, HydrogenatedWheat Germ Oil, Persea Gratissima Oil, Dead Sea Salt, Dimethicone, Caprylyl Glycol, Salicylic Acid, Tocopheryl Acetate, Calendula Officinalis, PEG-8, Lavandula Angustifolia Oil, Perfume Bianco, Bisabolol, Avena Sativa Straw Extract, Glyceryl Polyacrylate, Zeolite, Butylhydroxytoluol, Caprylyl Glycol, Lactic Acid)

• Placebo: The vehicle of Psorioderm® cream (containing moisturizing skin care products)

Period II.: All subjects apply investigational products with active ingredient (Psorioderm® shower gel, Psorioderm® lotion, Psorioderm® cream) to treat their psoriatic plaques every day

PERIOD I.:Method: Placebo-controlled, double-blind studyDuration of study: 10 March 2011 - 10 June 2011Number of analyzed subjects: 29 subjectsDiagnosis: mild to moderate plaque psoriasis which does not require biological therapyDuration of treatment: 6 weeks

Method: To assess the efficacy, PSI was determined every week. PSI, influenced by the extent of exfoliation, skin inflammation and thick-ness, indicates objectively the severity of the disease (maximum: 24 points) on the analyzed psoriatic area. At Visit 1, Visit 2 and Visit 8 VAS and PGA were determined. These parameters indicate the subjects’ and the physicians’ subjective opinion on the course of the disease.

Treatment - Results: In the study, 29 subjects were enrolled of which 27 subjects completed Period I. The mean duration of psoriasis was 22.9 years. On the affected skin of subjects, two symmetric areas (approximately 8x15 cm) were analyzed. There had to be a large or several smaller psoriatic plaques on the observed area. Each of their size had to be at least 10 cm2 and they also had to be localized far from each other. On the enrolment, there was no significant difference between PSI scores of Area 1 (treated with Psorioderm® cream, mean PSI: 15.2, median: 14.00) and Area 2 (treated with placebo, mean PSI: 15.2, median: 12.00) (Figure 3).

At the baseline the mean and the median of VAS scores were 5.52 and 5.00, the mean and the median of PGA scores were 3.86 and 4.00, respectively. Compliance was evaluated by a scale range from 1 to 5 at the end of the study. The subjects agreed to neither sunbathe, nor use tanning devices, nor apply other topical creams with active ingredient during the study.

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20-30%2- 4% 8 %

50%

50%3

1

70%

30%1

2

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RETROSPECTIVE POST MARKETING SURVEY 2010 - 2011

In 2010 - 2011 years, we created post-marketing survey was conducted in three European Union coun-tries: Hungary, Slovakia and Romania, by continuous routine application of Psorioderm® products in

subjects with mild to moderate plaque psoriasis and atopic dermatitis (AD) disease.

TARGET: MILD TO MODERATE PSORIASIS, AND ATOPIC DERMATITIS (AD) DISEASE.

The prevalence of PSORIASIS is said to be 2% - 4% of the world’s population. (In Norway ~8%) However, in the US and Canada, prevalences as high as 4.6% and 4.7% have been reported, respectively. Psoriasis can first appear at any age, from infancy to the eighth decade of life. Two peaks in age of onset have been reported: one at 20–30 years of age and a second peak at 50–60 years. In approximately 75% of patients, the onset is before the age of 40 years, and in 35–50%, it is before the age of 20 years. Although the age of onset is earlier in women than in men, the natural history is similar – chronic with intermittent remissions. In one epidemiologic study, 39% of the patients stated they had experienced remissions of 1–54 years.In Europe, the overall prevalence rate for juvenile psoriasis was found to be ~0.7%, with an increase from 0.37–0.55% in those 0 to 9 years of age to 1.01–1.37% in those 10-19 years of age. Plaque psoriasis is the most frequent form of the disease in children, followed by guttate psoriasis. Psoriasis spans all socioeconomic groups, and its prevalence varies by geographic location. Historically, the disease is more common in the northern latitudes. The rate of psoriatic disease is lower in African Americans compared with that in European Americans. Low incidence in West Africans, Japanese, and Inuits; very low inci-dence or absence in North and South American Indians.

The prevalence of ATOPIC DERMATITIS (ECZEMA) refers to a heterogeneous group of disorders that share similarities in clinical appearance and histopathologic findings, but may have very different etiologies. Atopic dermatitis (AD) is a common skin condition with significant associated social and financial burden. AD affects adults and children with worldwide preva-lence rates of 1-20%. International study of epidemiology and geographic variability in prevalence of AD has been conducted in three phases with 1,000,000 subjects in the third phase study. Prevalence continues to vary and has changed in different regions of the world. Nigeria, the United Kingdom and New Zealand had been areas of the highest prevalence; ~25-30%. Latin America has emerged as a region of relatively high prevalence in follow up data. The prevalence of AD seems to have

reached a plateau around 20% in countries with the highest prevalence, suggesting that AD may not be on a continued rise but that a finite number of indi-viduals may be susceptible to the condition. Risk factors associated with increased prevalence include higher socioeconomic status, higher level of family education, smaller family size and urban environment. Research indicates that food allergy and atopic sensitization to environmental allergens may not be directly causal of the condition and that a non-atopic form of the condition exists. 60% of patients will experience remission. The number of patients who will progress through the atopic march to develop asthma and allergic rhinitis depends on the underlying features of their condition. Atopic dermatitis (AD), also called atopic eczema, is a common chronic or recurrent inflammatory skin dis-ease and affects 15-20% of children, and 1-3% of adults worldwide. These numbers are much higher than for psoriasis, a disease that now has many good-targeted treatments for moderate to severe patients. There is a growing desire to explain the worldwide rise in the preva-lence of atopic dermatitis (AD).

PSORIASIS ATOPIC DERMATITIS (AD) DISEASE

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RESULTS:

359 Dermatologist and Pharmacist’s opinion was collect-ed from Hungary, Slovakia and Romania (2010 - 2011) by continuous routine application of Psorioderm® products in subjects with mild to moderate plaque psoriasis and atopic dermatitis (AD) disease.

The 28% of the surveyed patients had moderate psoriasis, and 72% of them had the mild type.

The most often used from the Psorioderm products was the Psorioderm Cream in 40%, the Psorioderm Sham-poo in 31%, the Psorioderm Body lotion in 15%, and the Psorioderm Shower gel in 14%

In the 58% of the patient’s opinion the symptoms were de-creased in its first week already. 17% of them felt the differ-ence after the second week. 13% of them after one month, and 12% of them did not respond. (75% the all patients’ opinion the symptoms were decreased in its first two week already.)

The 63% of respondents rated exceptionally good, the 37% rated high the Psorioderm product’s effect.

The 54% of the respondents use next to the Psorioderm cream at least another Psorioderm products for daily skin care.

For the 85% of respondents the first most spectacular im-provement was the “reduction in ichting and inflamma-tion”

The 81% of the respondents were happy that the producer is Hungarian and they can use Hungarian product.

The 73% of respondents were glad that the products are paraben-free. (Conscious Customers).

The 65% of respondents considered good to prepare a “sen-sitive product line” to atopic dermatitis, and childhood pso-riasis.

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GMP(medical product GMP)

Psorioderm is produced in a GMP fac-tory under strict quality

control Good manufacturing practices (GMP) are the practices required in order to conform to the guidelines recommended by agen-cies that control authorization and licensing for manufacture and sale of food, drug products, and active pharmaceutical products. These guidelines provide minimum requirements that a pharma-ceutical or a food product manufacturer must meet to assure that the products are of high quality and do not pose any risk to the consumer or public.

Good manufacturing practice guidelines provide guidance for manufacturing, testing, and quality assurance in order to ensure that a food or drug product is safe for human consumption. Many countries have legislated that food, pharmaceutical and medical device manufacturers follow GMP procedures and create their own GMP guidelines that correspond with their legislation.

ALL GUIDELINES FOLLOW A FEW BASIC PRINCI-PLES:

Hygiene: Pharmaceutical manufacturing facility must maintain a clean and hygienic manufacturing area. Controlled environ-mental conditions in order to prevent cross contamination of food or drug product from adulterants that may render the prod-uct unsafe for human consumption. Manufacturing processes are clearly defined and controlled. All critical processes are validated to ensure consistency and compliance with specifica-tions. Manufacturing processes are controlled, and any changes to the process are evaluated. Changes that have an impact on the quality of the drug are validated as necessary. Instructions and procedures are written in clear and unambiguous language. (Good Documentation Practices) Operators are trained to carry out and document procedures.Records are made, manually or by instruments, during manu-facture that demonstrate that all the steps required by the defined procedures and instructions were in fact taken and that the quan-tity and quality of the food or drug was as expected. Deviations are investigated and documented. Records of manufacture (in-cluding distribution) that enable the complete history of a batch to be traced are retained in a comprehensible and accessible form. The distribution of the food or drugs minimizes any risk to their quality.A system is available for recalling any batch from sale or supply. Complaints about marketed products are examined, the causes of quality defects are investigated, and appropriate measures are taken with respect to the defective products and to prevent recurrence.

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ISO-9001(MSZ EN ISO 9001: 2009 standard)

Pezomed Group in 2013 obtained ISO 9001 certification, which has been successfully repeated in 2014 year. This effectively established and operated a quality management system allows our organization to the customer requirements and regulatory requirements sufficient to manufacture our product and service we offer. Objective of the transparency of the system, and verify the stability of the process, guaranteeing quality and service for the products manufactured in both. Due to the system approach to management by the organization’s operations regulated ac-tivities transparent, the responsibilities and powers clear to all interested parties. Obtaining a certificate certifying that the op-eration and the results of the organization meet the domestic and international standards. Certop ISO 9001 certificate Pezomed Ltd., Pezomed Slovakia sro and Pezomed Rom Srl. The group has introduced Pezomed Hair Care manufacturing and trade, and uses a quality management system that conforms to ISO 9001: 2009 standard.

ISO 9001: 2009 standard features are: Quality Management System established and operated effectively allows the organ-ization to customer needs and the requirements of production manufacture and provide service. Objective of the transparency of the system, and verify the stability of the process, guarantee-ing quality and service for the products manufactured in both. Due to the system approach to management by the organiza-tion’s operations regulated activities transparent, the responsi-bilities and powers clear to all interested parties. The ratio of non-conforming products / services is reduced, the economical operation is increasing. Obtaining a certificate certifying that the operation and the results of the organization’s compliance with national and international standards.

„AA” Creditworthy (BISNODE CERTIFICATE)

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REFERENCESscientific literature

1. Nestlé FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med.2009;361:496–509.2. Christophers E. Psoriasis—epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26:314–20.3. Brandrup F, Green A. The prevalence of psoriasis in Denmark. Acta Derm Venereol. 1981;61:344–6.4. de Jong EMGJ, Seegers BAMPA, Gulinck MK, et al Psori-asis of the nails associated with disability in a large num-ber of patients; results of a recent interview with 1728 pa-tients. Dermatology. 1996;193:300–3.5. Swanbeck G, Inerot A, Martinsson T, et al. Age at on-set and different types of psoriasis. Br J Dermatol. 1995;133:768–73.6. Raychaudhuri SP, Gross J. A comparative study of pe-diatric onset psoriasis with adult onset psoriasis. Pediatr Dermatol. 2000;17:174–8.7. Farber EM, Nall ML. The natural history of 5600 patients.Dermatologica. 1974;148:1–18.8. Augustin M, Glaeske G. Radtke MA, et al. Epidemiology and comorbidity of psoriasis in children. Br J Dermatol. 2010;162:633–6..9. de Jager ME, van de Kerkhof PCM, de Jong EMGJ, et al. Epidemiology and prescribed treatments in childhood psoriasis: a survey among medical professionals. J Der-matolog Treat. 2009;20:254–8.10. Gelfand JM, Weinstein R, Porter SB, et al. Prevalence and treatment of psoriasis in the United Kingdom: a pop-ulation-based study. Arch Dermatol. 2005;141: 1537–41.11. Seyhan M, Coskun BK, Saglam H, et al. Psoriasis in childhood and adolescence: evaluation of demographic and clinical features. Pediatr Int. 2006;48:525–30.12. Andressen C, Henseler T. Inheritance of psoriasis. Analysis of 2035 family histories. Hautarzt. 1982; 33:214–7.13. Farber E, Nall L. Epidemiology: natural history and ge-netics. In: Roenigk HH, Maibach HI (eds). Psoriasis, 3rd edn. New York: Marcel Dekker, 1998:107–58.14. Schmitt-Egenolf M, Eiermann TH, Boehncke WH, et al. Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201- DQB1*0303: a population- and family-based study. J In-vest Dermatol. 1996;106:711–4.15. Christophers E, Henseler T. Psoriasis type I and II as subtypes of nonpustular psoriasis. Semin Dermatol. 1992;11:261–6.16. Bowcock AM, Krueger JG. Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol. 2005;5:699–711.17. Manolio TA, Collins PC, Cox NJ, et al. Finding the miss-ing heritability of complex diseases. Nature. 2009;461:

747–53.18. Genetic Analysis of Psoriasis Consortium & the Well-come Trust Case Control Consortium 2. Strange A, Capon F, Spencer CC, et al. A genome-wide association study in-dentifies new psoriasis susceptibility loci and an interac-tion between HLA-C and ERAP1. Nat Genet. 2010;42:985 90.19. Nair RP, Duffin KC, Helms C, et al. Genome-wide scanreveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009;41:199–204.20. Capon F, Di Meglio P, Szaub J et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and itsligand (IL12B) confer protection against psoriasis. Hum Genet. 2007;122:201–6.21. Gudjonsson JE, Ding J, Johnston A, et al. Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models. J Invest Dermatol. 2010;130:1829–40.22. Ong PY, Ohtake T, Brandt C, et al. Endogenous antimi-crobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;347:1151–60.23. Voorhees JJ. Pathophysiology of psoriasis. Annu Rev Med. 1977;28:467–724. Guilhou JJ, Meynadier J, Clot J, et al. Immunological aspects of psoriasis. II. Dissociated impairment of thy-mus-dependent lymphocytes. Br J Dermatol. 1976;95:295–301.25. Griffiths CE, Powles AV, Leonard JN, et al. Clearance ofpsoriasis with low dose cyclosporine. Br Med J (Clin Res Ed). 1986;293:731–2.26. Eady DJ, Burrows D, Bridges JM, Jones FG. Clearance of severe psoriasis after allogenic bone marrow transplan-tation. BMJ 1990;300:908.27. Gardembas-Pain M, Ifrah N, Foussard C, et al. Psori-asis after allogeneic bone marrow transplantation. Arch Dermatol. 1990;126:1523.28. Menssen A, Trommler P, Vollmer S, et al. Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J Immunol. 1995;155:4078–83.29. Boyman O, Heft HP, Conrad C, et al. Spontaneous de-velopment of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis fac-tor-alpha. J Exp Med. 2004;199:731–6.30. Nestlé FO, Conrad C, Tun-Kyi A, et al. Plasmacytoid predendritic cells initiate psoriasis through interferonal-pha production. J Exp Med. 2005;202:135–43.31. Conrad C, Boyman O, Tonel G, et al. Alphabetal integrinis crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med. 2007;13:836–42.32. Bonish B, Jullien D, Dutronc Y, et al. Overexpression ofCD1d by keratinocytes in psoriasis and CD1ddependentIFN-gamma production by NK-T cells. J Immunol. 2000;165:4076–85.

73

33. Nestlé FO, Turka LA, Nickoloff BJ. Characterization of-dermal dendritic cells in psoriasis: autostimulation of T lymphocytes and induction of Th1 type cytokines.J Clin Invest. 1994;94:202–9.34. Lowes MA, Chamian F, Abello MV, et al. Increase in TNF-alpha and inducible nitric oxide synthaseexpressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA. 2005;102:19057–62.35. Chamian F, Lowes MA, Lin SL, et al. Alefacept reduces infiltrating T cells, activated dendritic cells, and inflamma-tory genes in psoriasis vulgaris. Proc Natl Acad Sci USA. 2005;102:2075–80.36. Lande R, Gregorio J, Faccinetti V, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007;449:564–9.37. Ganguly D, Chamilos G, Lande R, et al. Self-RNAant mi-crobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med. 2009;206:1983–94.38. Detmar M, Brown LF, Claffey KP, et al. Overexpres-sion of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med. 1994;180:1141–6.39. Schonthaler HB, Huggenberger R, Wculek SK, et al. Systemic anti-VEGF treatment strongly reduces skin in-flammation in a mouse model of psoriasis. Proc Natl Acad Sci USA. 2009;106:21264–9.40. Krueger JG, Bowcock A. Psoriasis pathophysiolo-gy: current concepts of pathogenesis. Ann Rheum Dis. 2005;64(suppl. 2):ii30–36.41. Di Cesare A, Di Meglio P, Nestlé FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Der-matol. 2009;129:1339–50.42. Eyerich S, Eerich K, Pennino D, et al. Th22 cells repre-sent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119:3573–85.43. Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol. 2009;10:857–63.44. Ortega C, Fernandez AS, Carrillo JM, et al. IL-17- pro-ducing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cyto-kines. J Leukoc Biol. 2009;86: 435–43.45. Albanesi C, Scarponi C, Pallotta S, et al. Chemerin ex-pression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med. 2009;206:249–58.46. Gallo RL, Huttner KM. Antimicrobial peptides: an emerging concept in cutaneous biology. J Invest Dermatol. 1998;111:739–43.47. Bata Csorgo Z, Hammerberg C, Voorhees JJ, Cooper KD. Kinetics and regulation of human keratinocyte stem-cell growth in short-term primary ex vivo culture. Cooper-ative growth factors from psoriatic lesional T lymphocytes

stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes. J ClinInvest. 1995;95:317–27.48. Sano S, Chan KS, Carbajal S, et al. Stat3 links activatedkeratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005;11:43–9.49. Skov L, Baadsgaard O. Bacterial superantigens and in-flammatory skin diseases. Clin Exp Dermatol. 2000;25:56–61.50. Pacan P, Szepietouski JC, Kiejuo A. Stressful life events and depression in patients suffering from psoriasis vul-garis. Dermatol Psychosom. 2003;4:142–5.51. Verhoeven EWM, Kraaimaat FW, de Jong EMGJ, et al. Individual differences in the effect of daily stressors on pso-riasis: a prospective study. Br J Dermatol. 2009;161:295–9.52. Herron MD, Hinckley M, Hoffman MS, et al. Impact of obesity and smoking on psoriasis presentation and man-agement. Arch Dermatol. 2005;141:1527–34.53. Marrakchi S, Guigue P, Renshaw BR, et al. Interleukin- 36-receptor antagonist deficiency and generalized pustu-lar psoriasis. N Engl J Med. 2011;365:620–8.54. Radtke MA, Reich K, Blome C, et al. Prevalence and clinical features of psoriatic arthritis and joint complaints in 2009 patients with psoriasis: results of a German na-tional survey. J Eur Acad Dermatol Venereol. 2009;23:683–91.55. Moll JMH. Psoriatic arthropathy. In: Mier PD, van de Kerkhof PCM (eds). Textbook of Dermatology. Edinburgh: Churchill Livingstone, 1986:55–82.56. Reich K, Krüger K, Mössner R, Augustin M. Epidemi-ology and clinical pattern of psoriatic arthritis in Germa-ny: a prospective interdisciplinary epidemiological study of 1511 patients with plaque-type psoriasis. Br J Dermatol. 2009;160:1040–7.57. Brauchli YB, Jick SS, Miret M, Meier CR. Psoriasis and risk of incident cancer: an inception cohort study with a nested case-control analysis. J Invest Dermatol. 2009;129:2604–12.58. Mallbris L, Akre O, Granath F, et al. Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients. Eur J Epidemiol. 2004;19:225–30.59. Gelfand JM, Neimann AL, Shin DB, et al. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735–41.60. Neimann AL, Shin DB, Wang X, et al. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829–35.

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61. Gottlieb AB, Dann F. Comorbidities in patients with psoriasis. Am J Med. 2009;122:1150.e1–9.62. Miele L, Vallone S, Cefalo C, et al. Prevalence, char-acteristics and severity of non-alcoholic fatty liver dis-ease in patients with chronic plaque psoriasis. J Hepatol. 2009;51:778–86.63. Lee F, Bellary S, Francis C. Increased occurrence of psoriasis in patients with Crohn’s disease and their rela-tives. Am J Gastroenterol. 1990;85:962–3.64. Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthri-tis. Section 3: guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad Dermatol. 2009;60: 643–59.65. Kragballe K. Vitamin D in Dermatology. New York: Marcel Dekker, 2000.66. van de Kerkhof PCM, Wasel N, Kragballe K, et al. A two-compound product containing calcipotriol and beta-methasone dipropionate provides rapid, effective treat-ment of psoriasis vulgaris regardless of baseline disease severity. Dermatology. 2005;210:294–9.67. Kragballe K, Hoffmann V, Ortonne JP, et al. Efficacy and safety of calcipotriol plus betamethasone dipropio-nate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trial. Br J Dermatol. 2009;161: 159–66.68. Feldman SR, Yentzer BA. Topical clobetasol propionatein the treatment of psoriasis: a review of newer formula-tions. Am J Clin Dermatol. 2009;10:397–406.69. Katz HI, Hien NT, Prower SE, et al. Betamethasone in optimized vehicle. Intermittent pulse dosing for extend-ed maintenance treatment of psoriasis. Arch Dermatol. 1987;123:1308–11.70. van de Kerkhof PCM. Dithranol treatment for psori-asis: after 75 years, still going strong. Eur J Dermatol. 1991;1:79–88.71. Lew-kaya DA, Sefton J, Krueger FF, et al. Safety and ef-ficacy of a new retinoid gel in the treatment of psoriasis. J Invest Dermatol. 1992;98:600.72. Gribetz C, Ling M, Lebwohl M, et al. Pimecrolimus cream 1% in the treatment of intertriginous psoriasis: a double blind, randomized study. J Am Acad Dermatol. 2004;51:731–8.73. Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthri-tis. Section 5. Guidelines of care for the treatment of pso-riasis with phototherapy and photochemotherapy. J Am Acad Dermatol. 2010;62:114–35.74. Pathirana D, Ormerod AD, Saiag P, et al. European S3-Guidelines on the systemic treatment of psoriasis vul-garis. J Eur Acad Dermatol Venereol. 2009;23 (suppl 2):1–70.74a. Hsu S, Papp KA, Lebwohl MG, et al. Consensus guide-lines for the management of plaque psoriasis. Arch Der-matol. 2012;148:95–102.

75. Stern RS, Zierler S, Parrish JA. Methotrexate used for psoriasis and the risk of noncutaneous or cutaneous ma-lignancy. Cancer. 1982;50:869–72.76. Nyfors A, Jensen H. Frequency of malignant neoplasms in 248 long-term methotrexate-treated psoriatics. Derma-tologica. 1983;167:260–1.77. de Rie MA, Bos JD. Cyclosporine immunotherapy. Clin Dermatol. 1997;15:811–21.78. Timonen P, Friend O, Abeywickrama K, et al. Effica-cy of low dose cyclosporin A in psoriasis: results of dose finding studies. Br J Dermatol. 1990;122(suppl. 36): 33–40.79. Gollnick H, Bauer R, Brindley C, et al. Acitretin versus etretinate in psoriasis. Clinical and pharmacokinetic re-sults of a German multicenter study. J Am Acad Dermatol. 1988;19:458–69. 79a. Reich K, Langley RG, Papp KA, et al. A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis. N Engl J Med. 2011;365:1586–96.80. Gottlieb A, Korman NJ, Gordon KB, et al. Guidelines of care for the management of psoriasis and psoriatic arthri-tis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. J Am Acad Dermatol. 2008;58:851–64 81. Menter A, Gottlieb A, Feldman SR, et al. Guidelines of care for the management of psoriasis and psoriatic arthri-tis. Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008;58:826–50.82. Smith CH, Anstey AV, Barker JN, et al. British Assoc ation of Dermatologists’ guidelines for biologic interve-tions for psoriasis 2009. Br J Dermatol. 2009;161:987–1019.83. Sterry W, Barker J, Boehncke WH, et al. Biologi-cal therapies in the systemic management of psoriasis. International Consensus Conference. Br J Dermatol. 2004;151(suppl. 69):3–17.84. Driessen RJ, Boezeman JB, van de Kerkhof PC, de JongEM. Three-year registry data on biological treatment for psoriasis: the influence of patient characteristics on treat-ment outcome. Br J Dermatol. 2009;160:670–5.85. Mrowietz U, Christophers E, Altmeyer P, for the Geman Fumaric Acid Ester Consensus Conference. Treatment of severe psoriasis with fumaric acid esters: scientific back-ground and guidelines for therapeutic use. Br J Dermatol. 1999;141:424–9.86. Grundmann-Kollman M, Korting HC, Behrens S, et al. Treatment of chronic plaque-stage psoriasis and psoriatic arthritis with mycophenolate mofetil. J Am Acad Derma-tol. 2000;42:835–7. 87. Perez A, Raab R, Chen TC, et al. Safety and efficacy of oral calcitriol (1,25-dihydroxyvitamin D3) for the treat-ment of psoriasis. Br J Dermatol. 1996;134:1070–8.88. Kirby B, Fortune DG, Blushan M, et al. The Salford Pso-riasis Index: a holistic measure of psoriasis severity. Br J Dermatol. 2000;142:728–32.

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89. Mason AR, Mason J, Cork MJ, et al. Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev 2009;(2):CD0050028.90. Guenther L, Cambazard F, van de Kerkhof PCM, et al. Efficacy and safety of a new combination of calcipotri-ol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double blind, vehicle controlled clinical trial. Br J Dermatol. 2002;147:316–23.91. Lebwohl M, Freeman AK, Chapman MS, et al. Tacrlim-us ointment is effective for facial and intertriginous psori-asis. J Am Acad Dermatol. 2004;51:723–30.92. Spuls PI, Bossuyt PM, van Everdingen JJ, et al. The de-velopment of practice guidelines for the treatment of severe plaque form psoriasis. Arch Dermatol. 1998;134:1591–6.93. Christophers E, Griffiths CEM, Gaitanis G, van de Kerkhof PCM. The unmet treatment need for moderate to severe psoriasis: results of a survey and chart review. J Eur Acad Dermatol Venereol. 2006;20:921–5.94. van de Kerkhof PCM, Cambazard F, Hutchinson F, et al. The effect of the addition of calcipotriol ointment (50 μg/g) to acitretin therapy in psoriasis. Br J Dermatol. 1998;138:84–9.

95. Grossman RM, Thivolet J, Claudy A, et al. A novel thera-peutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporin: result of mul-ticenter placebo-controlled study. J Am Acad Dermatol. 1994;31:68–74.96. Gisondi P, Del Giglio M, Cotena C, Girolomoni G. Combining etanercept and acitretin in the therapy of chronic plaque psoriasis: a 24-week, randomized, con-trolled, investigator-blinded pilot trial. Br J Dermatol. 2008;158:1345–9.97. Marcil I, Stern RS. Squamous-cell cancer of the skin in patients given PUVA and cyclosporin: nested cohort cross-over study. Lancet. 2001;358:1942–5.98. Morrison WL, Momtaz K, Parrish A, et al. Combined methotrexate PUVA therapy in the treatment of psoriasis. J Am Acad Dermatol. 1982;6:46–51.99. Vanderveen EE, Ellis CN, Campbell JP, et al. Methotrex-ate and etretinate as concurrent therapies in severe psori-asis. Arch Dermatol. 1982;118:660–2.100. de Jager ME, de Jong EMGJ, van de Kerkhof PCM, et al. Efficacy and safety of treatments for childhood psori-asis: a systematic literature review. J Am Acad Dermatol. 2010;62:1013–30.

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