evolution and function of brain and cns and pns
DESCRIPTION
evolution of human brain and function of cns and pnsTRANSCRIPT
![Page 1: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/1.jpg)
Copyright (c) The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
1
CHAPTER 44
NEUROSCIENCE II:
EVOLUTION AND
FUNCTION OF THE
BRAIN AND
NERVOUS SYSTEMSPrepared by
Brenda Leady, University of Toledo
![Page 2: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/2.jpg)
2
Nervous system is the product of hundreds of millions of years of evolution
Development provided advantages that promoted reproductive success
Organization ranges from simple network of a few cells to complexity of human brain
![Page 3: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/3.jpg)
3
Representative nervous systems
Except for sponges, all animals have a nervous system
Nerve net Simplest nervous system Cnidarians (jellyfish,
hydras, anemones) Neurons connect to each
other in a network
![Page 4: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/4.jpg)
4
Echinoderms Slightly more sophisticated Nerve ring around mouth
connected to larger radial nerves extending to arms
Planaria Nerve cords extend length
of animal connected by transverse nerves
Collection of neurons in head form ganglia
Perform basic integration
![Page 5: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/5.jpg)
5
Annelids Same basic structure More neurons Ventral nerve cords
have ganglia in each segment
Simple mollusks Similar to annelids Pair of anterior ganglia Paired nerve cords
![Page 6: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/6.jpg)
6
Trend toward cephalization – increasingly complex brain in the head
Drosophila Brain has several
subdivisions with separate functions
Advanced mollusks Brains with well-
developed subdivisions
![Page 7: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/7.jpg)
7
Vertebrates and simpler chordates have a CNS (brain and spinal cord) and PNS
Organization shows similarities to segmentation of invertebrates
![Page 8: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/8.jpg)
8
3 divisions of vertebrate brain
Entire nervous system develops from neural fold in embryo
HindbrainMetencephalonMyelencephalon
MidbrainMesencephalon
ForebrainTelencephalonDiencephalon
![Page 9: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/9.jpg)
9
![Page 10: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/10.jpg)
10
HindbrainMedulla oblongata – coordinates many basic reflexes and bodily
functionsPons and cerebellum – responsible for monitoring and coordinating
body movements Midbrain
Processes several types of sensory inputControls sophisticated tasks
ForebrainHigher functions of conscious thought, planning and emotionCerebrumCerebral cortex – outer layer of cerebrumThalamus and hypothalamus
![Page 11: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/11.jpg)
11
Increased brain complexity
Size of cerebrum and surface area of cerebral cortex (convolutions) increased with more complex nervous systems
![Page 12: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/12.jpg)
12
![Page 13: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/13.jpg)
13
Body mass and brain mass proportional with exceptions (humans and dolphins)
Greater size and folding provides more surface area for greater processing and interpretation of information
![Page 14: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/14.jpg)
14
![Page 15: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/15.jpg)
15
Human nervous system
Central nervous system (CNS)Brain and spinal cord
Peripheral nervous system (PNS)Neurons and axons of neurons outside the
CNS
![Page 16: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/16.jpg)
16
![Page 17: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/17.jpg)
17
Nucleus – cell bodies of neurons involved in a similar function in the CNS
Ganglion – similar structure in PNS Tract – myelinated axons that run in parallel
bundles in the CNS Nerves – similar structure in PNS Cranial nerves are connected directly to the brain Spinal nerves are connections between the PNS
and spinal cord
![Page 18: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/18.jpg)
18
White matterMyelinated axons grouped together
Gray matterNeuronal cell bodies, dendrites and some
unmyelinated axons Spinal cord gray matter forms
Dorsal horns – connects to dorsal root, part of spinal nerve, incoming information
Ventral horns – connects to ventral root, part of spinal nerve, outgoing information
![Page 19: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/19.jpg)
19
![Page 20: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/20.jpg)
20
CNS encased in bone and 3 layers of meningesDura mater – outer thick layerArachnoid mater – numerous connections
to inner layerPia mater – inner thin membrane on
surface of brain and spinal cord Cerebrospinal fluid circulated through
subarachnoid spaceBetween arachnoid mater and pia materAbsorbs physical shocksTransportVentricles and central canal
![Page 21: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/21.jpg)
21
![Page 22: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/22.jpg)
22
PNS divisions
Somatic nervous system Sensory neurons (afferent) receive stimuli such as heat,
vision, smell, taste, hearing, touch and transmit to CNS Motor neurons (efferent) control skeletal muscles –
voluntary Autonomic nervous system
Predominantly composed of motor neurons (efferent) control smooth muscles, cardiac muscles and glands – involuntary
Sensory neurons (afferent) detect internal body conditions
![Page 23: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/23.jpg)
23
Efferent nerves of autonomic further divided Act on same organs with opposing actions Sympathetic division
“fight or flight” Increased heart rate, faster breathing
Parasympathetic division “rest and digest” Slow heart rate, promote digestion
![Page 24: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/24.jpg)
24
![Page 25: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/25.jpg)
25
Hindbrain
Medulla oblongataCoordinates many basic reflexes and bodily
functions that maintain the normal homeostatic processes of a person
Involved in the control of heart rate, breathing, cardiovascular function, digestion, swallowing, and vomiting
With pons and areas of the midbrain, collectively called the brainstem, contain additional nuclei (groups of cell bodies) whose axons project dorsally to many other parts of the brain
![Page 26: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/26.jpg)
26
![Page 27: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/27.jpg)
27
Hindbrain
Cerebellum and ponsResponsible for monitoring and coordinating
body movementsPons serves as relay between cerebellum and
other areas of the brainOverall function of cerebellum to maintain
balance and coordinate hand-eye movements
![Page 28: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/28.jpg)
28
Midbrain
Forms part of the reticular formation Processes several types of sensory
inputs, including vision, smell, and hearing Tracts that pass this information to other
parts of the brain for further processing and interpretation
![Page 29: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/29.jpg)
29
Forebrain
Thalamus and hypothalamus (diencephalon)
Cerebrum (telencephalon) – basal nuclei, limbic system and cerebral cortex
![Page 30: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/30.jpg)
30
Forebrain
Thalamus Major role in relaying sensory information to
appropriate parts of the cerebrum and, in turn, sending outputs from the cerebrum to other parts of the brain
Receives input from all sensory systems Hypothalamus
Major role of production of hormones regulating pituitary gland which regulates hormone secretion from other glands
![Page 31: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/31.jpg)
31
Forebrain Basal nuclei
Involved in planning and learning movements Involved in initiating or inhibiting movementsAffected in Parkinson disease
![Page 32: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/32.jpg)
32
Limbic system Not all agree on members of limbic system Primarily involved in formation and expression of
emotions Role in learning, memory, and perception of smells Amygdala – understand and remember emotional
situations, recognize emotional expressions in others Hippocampus – establish memories for spatial
locations, facts, and sequences of events
![Page 33: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/33.jpg)
33
Forebrain
Cerebral cortexSurface layer of gray matter on the cerebrumNeocortex layer evolved most recently in
mammals with only 6 layers of cellsContains 10% of neurons in the brainSensory and motor information integrated Initiation of voluntary acts, generation of speech,
learning, memory, and production of emotions
![Page 34: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/34.jpg)
34
Frontal – conscious thought and social awareness
Parietal – attention and making association between events and incoming information
Occipital – vision Temporal – language, learning, and some
types of memory
![Page 35: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/35.jpg)
35
![Page 36: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/36.jpg)
36
Sensory inputs come into the cortex and motor outputs leave the cortex in areas that stretch like a map
Amount of space proportional to sensitivity or number of muscles
May change depending on use or disuse of body part
![Page 37: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/37.jpg)
37
Cerebral hemispheres connected by corpus collosum
Severing connection used in the past to treat severe epilepsy
Hemispheres can function independently Process different types of information Left hemisphere – understanding
language and producing speech Right hemisphere – nonverbal memories,
recognizing faces, and interpreting emotions
![Page 38: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/38.jpg)
38
![Page 39: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/39.jpg)
Several Genes Have Been Important in the Evolution of the Cerebral Cortex
Genes identified by studying developmentally disabled individuals or comparing human genes to other species
Polymicrogyria – results in mental impairment, disrupted gait and language production Abnormal surface folds and fewer layers of cells Mutations alter receptors’ ability to bind ligand
Microcephalin and ASPM genes Determinants of brain size May be involved in brain evolution – greater changes in
humans and great apes
![Page 40: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/40.jpg)
40
Learning and memory
Learning – process by which new information is acquired
Memory – involves retention of that information over time
Long-term potentiation (LTP) Long-lasting strengthening of connections between neurons Experiments with rabbits showed short, electrical
stimulations to a neuron strengthened synapses with adjacent cells
Neurons communicated more readily
![Page 41: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/41.jpg)
41
Work with California sea slug (Aplysia californica)
Has only 20,000 nerve cells
Some neurons extremely large
Can isolate proteins and mRNA to identify biochemical and genetic changes during learning
Gill-withdrawal reflex subject to learning
![Page 42: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/42.jpg)
42
Sea slugs process in 2 phases Short-term memory lasts for minutes or hours
Typically single stimulus No new proteins Intracellular second messengers make it easier for
neurons to communicate Long-term memory lasts days or weeks
Repeated stimuli Activates genes, leads to mRNA synthesis, new
proteins for additional synaptic connections Learning does not change neuron pathways but
changes strength of signals along those pathways
![Page 43: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/43.jpg)
43
![Page 44: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/44.jpg)
44
Neurogenesis
Until recently, adult brain thought incapable of producing new neurons through cell division
Late 1990s, stem cells found in primate and human CNS
1998, found new hippocampal cells in recently deceased patients
Some evidence suggests that neurogenesis is involved in learning and memory
![Page 45: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/45.jpg)
45
Brain images in assessment
Computerized tomography (CT) scan – 3D image based on density but not great detail
Magnetic Resonance Imaging (MRI) – detection of structures as small as 1/10th mm
Function MRI (fMRI) – modification to assess functional activity based on oxygen in active tissue Oxygenated hemoglobin increases in metabolically
active areas
![Page 46: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/46.jpg)
46
![Page 47: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/47.jpg)
Gaser and Schlaug Showed That the Sizes of Certain Brain Structures Differ Between Musicians and Nonmusicians
Used MRI to examine sizes of brain structures in professional musicians, amateur musicians, and nonmusicians
Brain areas involved in hearing, moving the fingers, and coordinating movements with vision and hearing were larger in professional musicians than in amateur musicians, and larger in amateurs than in nonmusicians
Have not determined underlying reason(s) for increased brain size People with increased brain size in these areas may be more likely to
become musicians or musical training may cause these areas to enlarge
![Page 48: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/48.jpg)
![Page 49: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/49.jpg)
49
Impact on public health
Meningitis Viral or bacterial infection of meninges Increased pressure effects range from severe
headaches to death Bacterial infection can be treated with antibiotics Viral form less serious and short lasting Vaccine has reduced cases but still dangerous and
prevalent disease (especially close quarters like college dorms)
![Page 50: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/50.jpg)
50
Alzheimer’s disease (AD) Leading worldwide cause of dementia Characterized by memory loss and intellectual and
emotional function Definitive diagnosis can only be made after death 2 noticeable changes – senile plaques and
neurofibrillary tangles Not clear how changes influence function Genetics plays a role but not the only possible cause Impact on public health enormous – especially as
baby boomers age
![Page 51: Evolution and Function of Brain and Cns and Pns](https://reader035.vdocument.in/reader035/viewer/2022062404/55284c245503467f588b4724/html5/thumbnails/51.jpg)
51