exercise therapy in neuromuscular disease 05/10/2013 maryam tahmasbi sohi, md fellow in...
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Exercise TherapyIn
Neuromuscular Disease
05/10/2013
Maryam Tahmasbi Sohi, MD
Fellow in Neuromuscular Medicine
Department of Neurology
University of Kansas Medical Center
Objectives
• Overview of different types of exercise
• Physiologic responses to exercise
• Review of available literature for specific neuromuscular disorders
• Recommendations
• Will not cover pulmonary rehabilitation
Different Types of Exercise
Flexibility Training
• Involves stretching and range of motion • Reduces pain • Reduces spasticity • Increases joint
blood flow and
lubrication • Prevents contractures
Aerobic Exercise
• Prolonged low-resistance • Dynamic activity • Large muscle groups• Cardiopulmonary effects• American College of Sport Medicine (ACSM)
recommendation:– 30 minutes at 55%-90% of maximum heart rate
or– 40-85% of maximum oxygen uptake (VO2 max) – 4 days a week
Aerobic Exercise-Benefits
• Improves functional exercise capacity • Decreased psychological stress • Improves quality of life • Prevents secondary disease (DM, HTN,
CAD) • Improves sleep • Helps maintain bone density if performed in a
weight bearing manner • Produces greater independence with ADLs in
elderly population
Maximal Aerobic Capacity (VO2 Max)
• Maximum capacity of an individual's body to transport and use oxygen during incremental exercise
• Reflects the physical fitness of the individual • L/min or mL/kg/min• Graded exercise test while measuring ventilation, O2 and CO2 • O2 consumption remains unchanged despite an increase in workload
Isometric Exercise
• No change in muscle length • No visible joint movement • Primary use is for rehabilitation of joints
with limited ROM due to injury
or post op • Only increases strength
within a limited range of
motion (ROM)
Isokinetic Exercise
• Constant speed• Variable resistance
throughout the range of motion
• Lower chance of injury • Athletic training for
strengthening throughout
the required ROM
Nautilus- Upright Exercise Bike
Concentric Contraction
• Muscle shortens to generate force• Force generated is sufficient to overcome the
resistance
Eccentric Contraction • Muscle fibers lengthen• Force generated is insufficient to overcome
the external load on the muscle• Mean of decelerating a body part or object,
or lowering a load gently rather than letting it drop
• Negative training
Sarcomere
Delayed-Onset Muscle Soreness (DOMS)
• Muscular discomfort and pain • 24±48 h after strenuous exercise• Proximal and distal muscle tendon junctions spreading
throughout the entire muscle• Directly associated with the eccentric exercise (Asmussen
1952, 1956)
• Objective findings:– Strength loss– Reduced range of motion– Elevated serum creatine kinase (CK)
DOMS
• Z disk is the most vulnerable structure
• Type II fiber- biased damage (Lieber & FrideÂn 1988)
• Loss of desmin, inflammatory changes and necrosis in animals
• Older men are not as susceptible (Lavender and Nosaka; 2006)
Physiologic Response to Exercise
• Neural adaptation: – Accounts for early strength gain with training
programs (2 weeks) – Increase in muscle strength without noticeable
hypertrophy
• Muscular Adaptation: – 6-8 weeks to develop – Increase in muscle cross-sectional area (muscle
hypertrophy) in response to resistive exercise – Fast twitch (type II) fibers more than type I
Cross-transference
• Strength gain in the opposite, untrained limb following unilateral resistance training
• Due to neural adaptation• Improves the strength of a unmovable
injured limb or during post surgical period • Implication in research:
– Cannot use the opposite limb as control– 7.8-10% improvement in strength of the
untrained limb (Meta-analysis study)
Neuromuscular Disease Spectrum
• Motor neuron disease (ALS, polio)
• Nerve roots or peripheral nerves
• Neuromuscular junction transmission (MG, LEMS)
• Myofiber – Acquired (IBM, DM, PM)– Congenital (MD,
BMD,DM, Mitochondrial)
Questions to answer
Safe? Beneficial?
Studies in NMDs • Limited number of studies• Methodological limitations
– Lack of good controlled studies due to the rarity of NMDs– Grouped subjects with different NMDs with different
disease type, severity, and rate of progression– Little uniformity regarding the type of exercise
interventions (aerobic, strengthening, or combinations of exercise regimens),duration of exercise, intensity of exercise therapy, and initial state of physical activity and fitness
– Lack of clearly identified primary and secondary outcome measures
• Strength, endurance, fatigue, cardiopulmonary function, functional ability, activities of daily living, anxiety, depression, wellbeing, and pain
Muscular Dystrophies • Heterogeneous group of
hereditary muscle diseases
• Progressive muscle weakness
• Muscle fiber damage, inflammation, necrosis, and regeneration
• Defects in sarcolemmal and extracellular matrix proteins, essential in maintaining the cytoskeletal framework of the muscle fiber during muscle contraction
DMD BMD
Incidence 1 in 3,500 1 in 30,000
Age of Onset 3 to 5 yrs > 7 yrs
Dystrophin Mutation
Frameshift Mutation In-frame Mutation
CK Very high (5,000 to 20,000)
Presentation Proximal > Distal Symmetric Legs & Arms
Calf Hypertrophy
Failure to Walk 9 - 13 years 16-80 years
Cause of death Respiratory failure Cardiac
Strengthening Exercise
• Studies in dystrophin-deficient mdx mice have shown that dystrophic muscle is more susceptible to contraction-induced muscle damage compared to healthy mice
• Available randomized control trials are small in size, with inconsistent methodologies and conflicting results
• General consensus is that high resistance strengthening exercises are contraindicated in patients with dystrophinopathy
Unstable sarcolemma makes the muscle susceptible to mechanical stress , muscle fiber necrosis, fiber loss, and replacement with fibrotic tissue
Disruption of dystrophin down regulates nitric oxide synthase (nNOS), which leads to disregulation of blood flow to the muscle and functional muscle ischemia
Tadalafil-Muscle Ischemia-BMD
“Tadalafil Alleviates Muscle Ischemia in Patients With Becker Muscular Dystrophy”•Randomized placebo-controlled crossover trial•Tadalafil (phosphodiesterase 5A inhibitor)•Functional muscle ischemia is alleviated and normal blood flow regulation is fully restored in the muscles of men with BMD•There were no adverse events or side effects
Martin et al 2012
Endurance Training and BMD Method:
•Eleven patients with BMD and seven healthy subjects
•All patients were ambulant
•Onset of symptoms at age 8 ± 2years
•Asymptomatic cardiomyopathy (LVEF):35–45% in 3 patients
•Forced vital capacity (FVC) was on average decreased by 14±2% (within normal limits)
Primary Outcomes: VO2max, Plasma Ck, and self report questionnaire
Intervention: Cycled 50, 30min sessions at 65% of their VO2max over 12 weeks, and six patients continued cycling for 1 year
Sveen et al 2008
Endurance Training and BMDResults:
– Improved VO2max by 47± 11% in patients (P0.005)– Weekly CK levels did not increase with training– No change in the number of central nuclei, necrotic and
regenerating fibers– Strength in muscles involved in cycle exercise (knee
extension, and dorsi- and plantar-flexion) increased significantly by 13-40%.
– Cardiac pump function, measured by echocardiography, did not change with training
– All improvements and safety markers were maintained after 1 year of training
Conclusion: – Moderate endurance training is safe to increase exercise
performance and daily function in patients with BMD
Sveen et al 2008
High Intensity Endurance Training“Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy”Method: •Fourteen patients with muscular dystrophy (BMD: 5, FSHD: 5 , LGMD2-I and LGMD2-A: 4 ) •Eight healthy subjects •5 cycling tests at 65, 75, 85 and 95 % of VO2 max•Heart rate and oxygen consumption were measured during tests•Plasma CK was measured before, immediately after, and 24 hours after exercise
Anderson et al 2013
High Intensity Endurance Training
Results: •Plasma CK increased after all exercise tests in all patients •In persons affected by LGMD2A, LGMD2I, and FSHD, plasma CK declined to the pre-exercise level 24 hours after exercise•Plasma CK remained elevated 24 hours after exercise in persons with BMD (only after the 95% of VO2max test)•The subjects never scored higher than 3.5 on the leg pain VAS (immediately after exercise)
Anderson et al 2013
High Intensity Endurance Training
Conclusion:
•High-intensity aerobic exercise is generally well-tolerated in persons with LGMD2 and FSHD
•Patients with BMD may be more prone to exercise induced damage
•Closer supervision of training is warranted if high-intensity exercise is implemented
Anderson et al 2013
Idiopathic Inflammatory Myopathies (IIM)
• Heterogeneous group of rare disorders that present with acute, subacute, or chronic muscle weakness
• Overlapping clinical manifestations• Divergent from the histopathological and
pathogenetic standpoints• Generally respond well to immunosuppressive
therapy• Inclusion body myositis (IBM), the most common
IIM in the elderly, is clinically, histopathologically and pathogenetically distinct
• IBM is refractory to all currently available therapies
Exercise and IIM• Studies in active and chronic disease phase
have been reported
• All demonstrated the safety and efficacy of exercise
• Neuromuscular specialists usually wait for the first two to three months for strength and CK to start responding to pharmacotherapy before starting the strengthening exercise program
• Early mobilization is important to prevent flexion contractures
Dimachkie 2011
Exercise and IBM (Arnardottir et al, 2003): •A home exercise program, five days a week for 12 weeks, was found to be safe in seven patients. There was no strength deterioration, no change in serum CK, and no increased in muscle inflammation on biopsy
(Johnson et al., 2009): •Aerobic exercise program using a stationary cycle ergometer at 80% of the initial maximum heart rate (for two minutes less than the total time achieved during maximal aerobic test) combined with resistance isometric and isotonic exercises of the upper and lower limbs in a group of seven IBM cases. Besides demonstrating it to be safe, they found this exercise routine to improve aerobic capacity and muscle strength.
Dimachkie 2011
Mitochondrial Myopathy • Heterogeneous group of metabolic muscle disorders• Mutation in either nuclear or mitochondrial DNA (mtDNA)• Brain and skeletal muscles are particularly susceptible • Single-organ to multisystem disorders (muscle weakness
or exercise intolerance, arrhythmia, dementia, movement disorders, stroke-like episodes, deafness, blindness, ophthalmoplegia, and seizures)
• Heteroplasty: mtDNA mutations coexist with wild-type mtDNA (Mild phenotypes have higher proportions of wild-type mtDNA)
• Mature muscle cells have a high degree of mtDNA mutations, whereas the level of mutations is low or undetectable in satellite cells
Exercise in MT-Myopathy
• Resistance exercise serves as stimulus for satellite-cell induction within skeletal muscle, lowering the level of mutant mtDNA and improving oxidative capacity (Murphy et al 2008)
• The beneficial effects of endurance training have been reported in 8 published reports, with no adverse effects
• Hypothesized to induce mitochondrial biogenesis and capacity for oxidative phosphorylation improve function
Amyotrophic Lateral Sclerosis (ALS)
• Progressive degenerative disease of the upper and lower motor neuron
• Majority of cases are sporadic (90%)• Hereditary defect in the superoxide dismutase
(SOD) gene (20%)• Studies of exercise on SOD deficient mice
suggest that endurance exercise training at moderate intensities slows disease progression, and increases lifespan
• High-intensity exercise showed no improvement or hastened symptoms and death
Exercise and ALS
• Twenty-five patients were randomized to receive a moderate daily exercise program (n=14) or control (n=11)
• Outcome measures at baseline and after 3, 6, 9 and 12 months– Manual muscle strength testing– Ashworth spasticity scale– ALS functional rating scale (ALSFRS)– Visual analog scale for pain – Quality-of-life scale (SF-36)
Drory et al 2001
Exercise and ALS
• At 3 months, patients who performed regular exercise showed less deterioration on FRS and Ashworth scales, but not on other parameters
• At 6 months, there was no significant difference between groups, although a trend towards less deterioration in the treated group on most scales was observed
• At 9 and 12 months, there were too few patients in each group for statistical evaluation
Exercise and ALS Method:
27 patients with a diagnosis of ALS, FVCof ≥90% predicted, and ALS Functional Rating Scale (ALSFRS) score of 30 or greater were randomly assigned to a resistance exercise group (n=13) or to a usual care group (n=14)
Results:
- Eight resistance exercise subjects and 10 usual care subjects completed the trial
- At 6 months, the resistance exercise group had significantly higher ALSFRS and SF-36 scores -No adverse events -Less decline in leg strength measured by MVIC
Bello- Haas et al 2007
Post Polio Syndrome
• Affects individuals who had a confirmed case of polio with a partial or fairly complete neurological and functional recovery after the acute episode
• At least 15 years of neurological and functional stability
• Presenting with gradual or abrupt onset of new muscle weakness, muscle atrophy, muscle pain, and fatigue
• Persists for more than 1 year
Exercise in PPS • European Federation of Neurological Society
(ENFS) task force determined that both aerobic training and progressive resistance exercise training can benefit individuals with PPS (2006)
• Systematic analysis by Cup et al in 2008 determined that there is insufficient evidence to assess the effectiveness of muscle strengthening exercises, aerobic exercises, or a combination of these exercises in individuals with PPS
Abresch et al 2009
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Halstead et al 2010
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Proposed Exercise in PPS
• Class 1: – Moderate intensity: 60-80% maximal HR – Duration: 15-30 min– Frequency: 3-5/week
Examples: • Swimming 25-35 yards/min • Walking 5-6 mph • Bicycle riding 12-14 mph
Halstead et al 2010
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Proposed Exercise in PPS
• Class II:– Moderate intensity: 60-80% maximal HR – Duration: 15-30 min– Frequency: 3-4/week on alternate days – Pacing: perform 4-5 min, rest 1 min
*Decrease if pain, fatigue or new weakness
Halstead et al 2010
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Proposed Exercise in PPS
• Class III: – Low intensity: 40-60% of max HR – Duration: 15-20 min– Frequency: 3-4/week – Pacing: Resting 1 min/2-3 min of activity
*modify if new weakness, pain or fatigue
Halstead et al 2010
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Proposed Exercise in PPS
• Class IV: – Trial of rest to exclude overuse weakness – Daily active/passive stretching program – No cardiopulmonary aerobic exercise – If overuse is excluded, trial of monitored, non-
fatiguing, progressive resistive exercise program
– If overuse weakness, modify activity, use bracing, scooter, etc.
Halstead et al 2010
Class Remote Weakness
Recent Weakness
Exam * EMG/NCS**
I No No Normal Normal
II No No Normal Chronic denervation
III Residual No Abnormal Chronic ± Active denervation
IV Residual Yes Abnormal Chronic ± Active denervation
V Residual yes Abnormal ↓insertional activity Chronic ± Active denervation
*: Visible atrophy, Manual muscle testing, DTRs, sensation **: biceps, triceps, and FDI in UE and Med gastroc, TA, and Quad in LE
Proposed Exercise in PPS
• Class V: – Performing activities of daily living – Bracing and/or wheelchair usually needed
Halstead et al 2010
Diabetic Neuropathy • Pilot study • Seventeen subjects (8 males/9 females; age 58.4±5.98; duration
of diabetes 12.4±12.2 years) • 10- week supervised, moderately intense aerobic and resistance
exercise program• Outcome measures:
– Pain (visual analog scale)– Michigan Neuropathy Screening Instrument (MNSI)– Intraepidermal nerve fiber (IENF) density and branching
RESULTS: • Significant reductions in pain, neuropathic symptoms, and
increased intraepidermal nerve fiber branching from a proximal skin biopsy
Pasnoor et al 2012
Conclusion
1. Individuals with NMDs should adopt an active lifestyle for its physical and psychological benefits
2. Stretching and range-of-motion exercises may be helpful in decreasing the discomfort due to the limited joint mobility
3. Moderate resistance exercise should be given to patients with antigravity strength or better to maintain strength
Abresch et al 2012
Conclusion
4. Moderate aerobic exercise should be given to prevent deconditioning and loss of cardiopulmonary fitness5. High-intensity exercises relative to an individual’s strength should be avoided6. The intensity and frequency of exercise should be tailored to individual's level of physical fitness and need7. The effects of exercise should be closely monitored
Abresch et al 2012
What to Tell Patients?
• Moderate:
• 40-60% VO2 Max or 60%of maximum HR
• Walking as fast as 100 steps per minute
• Breathing quickens, but not out of breath
• Develop a light sweat after about 10 minutes of activity
• Can carry on a conversation, but you can't sing
What to Tell Patients?
Vigorous exercise intensity
•Breathing is deep and rapid
•Develop a sweat after a few minutes of activity
•Cannot say more than a few words without pausing for breath
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Thank You