expanding biomedical research in maine mount desert island biological laboratory patricia h. hand,...

Expanding Biomedical Research in Maine

Mount Desert Island Biological Laboratory

Patricia H. Hand, Ph.D.

Administrative Director

Mount Desert Island Biological

Laboratory• 108 year old biomedical and marine

research institution - oldest in state

• Historically a seasonal institution with scientists from 65 institutions

• Dramatic growth since 2000

• Now have 7 full-time scientific groups

• 1999 - 9 employees

• 2006 - 41 employees

• Federal funding: 0.5 - 6M

• Operating budget: 0.75 - 7.9M

MISSION

To promote research and education in the biology of marine organisms;

to foster understanding and preservation of the environment;

and to advance human health.

ResearchResearch

• 21 year history of NIH Toxicology Center funding in Environmental Health

• Established nation’s first Center for Marine DNA Sequencing (sequencing of the skate and sea urchin genomes)

• Established nation’s first Center for Marine Functional Genomic Studies

• Development of the Comparative Toxicogenomics Database

• Two companies from discoveries at MDIBL

•Dramatic increase in educational programs

•Providing hands-on technical training to more than 300 students per year

•Well positioned to address Maine’s need for a technically skilled workforce

Educational Educational ProgramsPrograms

IDeA Network of IDeA Network of Biomedical Biomedical Research Research

ExcellenceExcellence

INBREINBRE

•$26 M NIH grant to MDIBL to strengthen Maine’s research capacity and competitiveness

•Partnership between MDIBL and eight Maine institutions

IDeAIDeA: : IInstitutional nstitutional DDevelopment evelopment AAwardward

• National Center for Research Resources (NCRR), National Institutes of Health (NIH)

• Broadens the geographic distribution of NIH funding

• Two main components:

- Centers of Biomedical Research Excellence (COBRE)

- IDeA Networks of Biomedical Research Excellence (INBRE)

IDeA StatesIDeA States

MaineMaine I IDeA DeA NNetwork of etwork of BBiomedical iomedical RResearch esearch EExcellencexcellence

Maine INBRE Supports…

• Undergraduate Student Research Training to more than 600 students over 5 years

• Junior Faculty Development

• Institutional Development

• Outreach


Undergraduate Research TrainingUndergraduate Research Training

Annual Short Courses

Laboratory in Behavioral Neuroscience

Functional Genomics of Membrane Transport

Environmental Toxicogenomics

Molecular Biology Research Techniques


Undergraduate Research TrainingUndergraduate Research Training

Summer Fellowships

• 8-10 weeks

• Available to students attending Maine undergraduate institutions

• Mentor is federally-funded established scientist


Junior Faculty Research/Comparative Functional GenomicsJunior Faculty Research/Comparative Functional Genomics

REPRESENTATIVE MAINE INBRE RESEARCH PROJECTS & LEADERS

Clare Congdon, Ph.D., Colby CollegeMachine Learning Methods for Phylogenetics and Genomics

Joel Graber, Ph.D., The Jackson LaboratoryBioinformatics of Post-transcriptional Regulatory Elements

Carolyn J. Mattingly, Ph.D., MDI Biological LaboratoryIdentification of Novel Regulatory Sequences in ABCB and ABCC Subfamily Genes by Comparative Genomic Analysis

Antonio Planchart, Ph.D., College of the Atlantic, MDI Biological LaboratoryDiscovery and Characterization of Conserved Motifs that Regulate Gene Expression During Spermatogenesis

Nicole J. Theodosiou, Ph.D., Bowdoin CollegeWnt Signaling in the Developing Gastrointestinal Tract

Rebecca J. Sommer, Ph.D., Bates CollegeDioxin Exposure Impairs Embryonic Heart Development: Comparative Expression and Promoter Analysis of the Beta1- Adrenergic Receptor


INSTITUTIONAL DEVELOPMENTINSTITUTIONAL DEVELOPMENT

According to the Needs of Each Institution

• Imaging Facility

• Technician for Core Facility or to Work with Faculty Group

• Student Research Fellowships: academic & summer

• Research Equipment

• Electronic Journals

• Meeting Travel

• Sponsored Program Office Development

• Collaborative Research

• Seminars/Visiting Scientists

MaineMaine I IDeA DeA NNetwork of etwork of BBiomedical iomedical RResearch esearch EExcellencexcellenceOUTREACHOUTREACH

Conferences & Symposia

• Maine Biological and Medical Sciences Symposium

• Bioinformatics Workshop

Seminars/Visiting Scientists

Short Courses

Undergraduate & Graduate Student Fellowships


Maine INBRE StructureMaine INBRE Structure


Communications Communications

www.maineidea.net

WebsiteWebsite

NewsletterNewsletter QuarterlyFeatures each institutionDownload at the Maine INBRE website


MEASURES OF SUCCESSInstitutions

• good working relationship; collaborations

• other institutions seek to be included

Junior Faculty

• collaborating with each other

• publications: 37 published, 13 in press, 4 submitted

• grants: 25 submitted, 13 funded, 7 pending

• one awarded R01 grant, independence

Students

• increased number of science majors

• graduate, medical school, research jobs

expanding biomedical research in maine mount desert island biological laboratory patricia h. hand,...

Documents

maines research capacity

research resources ncrr

maine institutions idea

nih grant

seasonal institution

employeesfederal funding

human health

institutions dramatic