Funded by the

National Institute of Allergy and Infectious Disease (NIAID)

www.fludb.orgwww.viprbrc.org

IRD and ViPR are constantly evolving and we appreciate your valuable suggestions

at feedback@virusbrc.org

Expect More from Your Database

What they are & what they do…

The Influenza Research Database (IRD) and Virus

Pathogen Resource (ViPR) are freely available,

NIAID-funded resources that support the research

of viral pathogens in the NIAID Category A-C

Priority Pathogen lists and those causing

(re)emerging infectious diseases. IRD and ViPR

integrate data from external sources (GenBank,

UniProt, Immune Epitope Database, Protein Data

Bank, etc.), direct submissions, and internal

curation and analysis pipelines, and provide a suite

of bioinformatics analysis and visualization tools to

expedite virology research.

www.fludb.orgwww.viprbrc.org

Caliciviridae

Filoviridae

Picornaviridae

Hepeviridae

Coronaviridae

Paramyxoviridae

Togaviridae

Poxviridae

Flaviviridae

Rhabdoviridae

Arenaviridae

Herpesviridae

Reoviridae

Bunyavirales

Dengue

Ebolavirus

Enterovirus

Hepatitis C Virus

Lassa Virus

Zika Virus

Virus Families Featured Viruses

Influenza Virus

Sequence curation pipeline

flags potential sequence artifacts

Search and Retrieve Data• Genomes, genes, proteins and annotations• Mature peptide predictions from polyproteins• Genotypes, subtypes and clades• Influenza consensus sequences & polymorphism scores• Protein ortholog groups• Immune epitopes• Sequence Features (SFs) including phenotype markers• Surveillance, clinical and serology data• 3D protein structures• Host factor data• Antiviral drug data• Commonly-used PCR primers• Computationally-derived data• Sequence search API

Analyze and Visualize• BLAST sequence similarity search• Short peptide search• Genome annotation including SF annotation• Flavirvirus & Rotavirus genotype/subtype prediction• Influenza H1 and H5 clade classification• Influenza HA subtype numbering conversion• Multiple sequence alignment• Computationally intensive phylogenetics• Metadata-driven Comparative Analysis Tool• Sequence Variation (SNP) analysis• Sequence Feature Variant Type (SFVT) analysis• 3D protein structure visualization• Host factor enrichment & network analysis• PCR primer design

Save to Workbench• Save and share private data and analysis results • Share data and analysis results with collaborators• Analyze your own data/metadata using IRD/ViPR tools

Sequence Submission• Process sequence data for GenBank submission

Phylogenetic tree inference and visualization

Meta-CATS reports positions significantly different between groups of sequences

3D protein structure with epitopes

& sequence conservation highlighted

www.fludb.org www.viprbrc.org

Mature peptide annotations

for viruses that generate polyproteins

Comparative evolutionary genomics based

on orthology and protein domain architecture

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Ortholog Group Search Result

Avian influenza surveillance data mapping

Host factor data models

A/North Carolina/1/1963

A/England/12/1962

A/Korea/426/1968

88

A/Berlin/3/1964

A/Izumi/5/1965(R)(H2N2)

A/England/1/1966

A/Potsdam/2/1965

88

A/Victoria/5/1968

A/Georgia/1/1967

A/Netherlands/61/1968

98

21

18

42

42

27

Asia

Node ShapeRegion

EuropeNorth AmericaOceania

1962

Label ColorYear

196319641965196619671968

E

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Metadata-driven Comparative Analysis Report

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