exploiting the potential of commercial flight-proven ... · in this context, organ on chip...
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Exploiting the potential of commercial flight-proven hardware for organ on chip experimentation in space
Alessandro Donati*, Michele Balsamo, Luca Pieroni, and Valfredo Zolesi
[email protected], [email protected]; [email protected], [email protected]
* Corresponding author
KAYSER ITALIA S.r.l. Via di Popogna 501 – 57128 Livorno - ITALY
KEU-ST
Seeds
KEU-AT
KEU-OC
KEU-Y2
KIC-DLM
KEU-Y1
KIC-SLC
KUBIKIncubator with
centrifuge
BIOREACTOR EXPRESSThe Express Road to Your Discovery
2D / 3D culture(cells or tissues)
Small Animals C. Elegants,
Rotifers
Bacteria
Algae
Aquaria for Xenopus or
fish
Small Plants
KEU-PK
KEU-BA1
KEU-BA2
KEU-RO
KEU-XEKEU-RK
KEU-MM
KIC-SL
KIC-DL
KIC-SL-E
KIC-DL-E
KIC-SLA-E3W
Biofilms
2D Cell Culture
2D OsteoclastCell Culture
CrewOperated
Two Levelsof Containment
One Levelof Containment
TransparentWindow
1 Liter of Volume
Aerobic Bacteria
MonocytesCell Culture
Anaerobic Bacteria
T-Cell Culture
Yeast
KEU is integratedinto the Experiment
Container (KIC).The KIC provides
additional Levels of Containment (LoC)
FULL SCIENTIFIC SUPPORT TO YOUR EXPERIMENT IN MICROGRAVITY ON-BOARD THE INTERNATIONAL SPACE STATION (ISS)
Space life science research is of paramount importance for the future planned human activities on board ISS, the Lunar Gateway, or for the colonization of Mars, becauseeither gives insights into the effects of space flight on a number of biological model systems or provides countermeasures to fight the hostile effects of the spaceenvironment on the human body. State of the art experiment hardware proven to be successful in space operations and scientific results is therefore a valuable asset for thesupport of scientific investigations. In this context, organ on chip technology coupled to flight hardware could represent a very useful tool to tackle the above mentionedlines of space research.
Kayser Italia develops space hardware systems and provides missionsupport for investigations on biological systems in space. Several types ofbioreactors have been developed, they reduce a laboratory into a hand-sized device dedicated to life science reserarch experimentation in spaceplatforms. They allow the autonomous execution of a scientific protocol,being designed to contain the cell culture and all the chemicals requiredby the experiment. To maintain a desired temperature during theexperiment execution an incubator is employed. Kayser Italia haslaunched a commercial service called ʺBIOREACTOR EXPRESSʺ. It offers alarge portfolio of bioreactors and containers for several categories ofexperiments: cell biology, organ on chip, plant physiology, foodproduction, material science, fluid science, educational, etc. that can besupported inside the ESA KUBIK incubator. BIOREACTOR EXPRESS providesall services and resources necessary to perform the experiment on boardISS, allowing the user to focus on the exploitation of the research results.
Embedded PROGRAMMABLE electronics for full
AUTONOMOUS execution of scientific protocols
KEU reduces a laboratory into ahand-sized electromechanical device
FULLY AUTOMATIC MINIATURIZED BIOREACTORS
http://www.kayser.it http://www.bioreactorexpress.space [email protected]
KEU contains specimen & chemicals(medium, wash buffers, fixative)
ORGAN ON CHIP IN MICROGRAVITY
CHIP is integrated into the Experiment Container (KIC)
CHIP
Yeast