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Basic Genetics (SQBS 2753)
Extensions of MendelismExtensions of Mendelism
Azman Abd Samad
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Beyond MendelBeyond Mendel…
• Since Mendel’s work was rediscovered in theSince Mendel s work was rediscovered in the early 1900’s:– Researchers have studied the many ways genes– Researchers have studied the many ways genes influence an individual’s phenotype
– These investigations are called neo‐MendelianThese investigations are called neo Mendelian genetics (neo from Greek for “new”)
– This chapter examines types of inheritanceThis chapter examines types of inheritance observed by researchers that did not conform to the expected Mendelian ratios
Extensions of Mendelian GeneticsExtensions of Mendelian Genetics
• How alleles affect phenotypeHow alleles affect phenotype– Not always simple dominant/recessive issue
• Gene interaction• Gene interaction– Phenotype controlled by more than one gene
• Sex‐linked genes (X‐linkage in X/Y organisms)
• Phenotype can depend on more than genotype– Environmental effects
Extended Mendelian Inheritance PatternsExtended Mendelian Inheritance Patterns• Incomplete dominance
Heterozygosity at a locus produces a third 3 phenotype– Heterozygosity at a locus produces a third 3 phenotype intermediate to the two homozygous phenotypes
• Co‐dominance– Heterozygosity at a locus produces a single unique phenotype different from either homozygous condition
• Overdominance– Heterozygosity at a locus creates a phenotype that is more b fi i l d t i t l th h it fbeneficial or more deterimental than homozygosity of either locus with any allele
Extended Mendelian Inheritance PatternsExtended Mendelian Inheritance Patterns
• LethalityLethality– Homozygosity of an allele kills the cell or organism
• Penetrance• Penetrance– A measure of how variation in expression of a given allele occursgiven allele occurs
– incomplete penetrance describes the lack of effect a deleterious allele might have in an individuala deleterious allele might have in an individual carrying it
Extended Mendelian Inheritance PatternsExtended Mendelian Inheritance Patterns
• Sex‐linkedSex linked– inheritance of genes on that are unique to a sex chromosomes
– pseudoautosomal genes – genes on both sex chromosomes appear to be on autosomes
S i fl d• Sex‐influenced– An allele is expressed differently in each sex. Behaving dominantly in one sex and recessively in the otherdominantly in one sex and recessively in the other
• Sex‐limited– An allele is only expressed in one or the other sexy p
EXTENSIONS TO MENDEL FOREXTENSIONS TO MENDEL FORSINGLE‐GENE INHERITANCE
Complete Dominance/RecessivenessComplete Dominance/Recessiveness
• recessive allele does not affect the phenotyperecessive allele does not affect the phenotype of the heterozygote
• two possible explanations• two possible explanations– 50% of the normal protein is enough to accomplish the protein’s cellular functionaccomplish the protein s cellular function
The normal gene is “up regulated” to compensate– The normal gene is up‐regulated to compensate for the lack of function of the defective allele
Simple Mendelian InheritanceSimple Mendelian InheritanceNormal/dominant alelle: P (purple)Recessive/defective alelle: p (white)Recessive/defective alelle: p (white)
Genotype PP Pp pp
Amount of 100% 50% 0%
functional protein100% 50% 0%
Phenotype Purple Purple White
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Incomplete DominanceIncomplete Dominance
• Heterozygote exhibits a phenotype intermediate to the yg p yphomozygote
• Also called intermediate dominance or dosage effect
• Example: Flower colour of snapdragon
• Phenotypic ratio: 1 (red) :2 (pink):1 (white) and NOT the 3:1 ratioratio
Phenotype Genotype Amount of gene productgene product
Red RR 2X
Pink Rr X
White rr 0
Gene Dosage – A form of intermediate d idominance
• Alleles of white –Alleles of white – X‐linked eye color gene in Drosophila
W red (wildtype gene)– W – red (wildtype gene)
– w ‐ white
i– we ‐ eosin
• we allele was expressed with different i i i hintensity in the two sexes– Homozygous females eosin
– Males light‐eosin11
Gene DosageGene Dosage
• Morgan & Bridges hypothesized thatMorgan & Bridges hypothesized that difference in intensity was due to the difference in number of X chromosomesdifference in number of X chromosomes– Female has two copies of the “eosin color producer” alleleproducer allele
• Eyes will contain more color
– Males have only one copy of the alleleMales have only one copy of the allele• Eyes will be paler
• This is an example of gene dosage effectThis is an example of gene dosage effect
CodominanceCodominance– two alleles at a locus produce different andtwo alleles at a locus produce different and detectable gene products in heterozygote
– No dominance or recessiveness
– No “blended” phenotype (not incomplete dominance)
• Example: MN blood group in humans– Red blood cell glycoprotein surface antigen hasRed blood cell glycoprotein surface antigen has two forms (M and N)
– An individual may exhibit either or bothAn individual may exhibit either or both
CodominanceCodominance
For example:For example:
• One serum (anti‐M) recognises only the M antigen; anti‐N recognises only N antigeng y g
• Antigen M reacts with anti‐M causes AGGLUTINATION
Genotype Phenotype
LMLM MMLMLM MM
LMLN MN
LNLN NNL L NN
Multiple AllelesMultiple Alleles
• The term multiple alleles is used to describeThe term multiple alleles is used to describe situations when three or more different alleles of a gene existof a gene exist
• Examples:ABO bl d– ABO blood
– Coat color in many species
l h l– Eye color in Drosophila
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Multiple AllelesMultiple Alleles• ABO blood phenotype is determined by multipleABO blood phenotype is determined by multiple alleles
• ABO type result of antigen on surface of RBCsyp g– Antigen A, which is controlled by allele IA
– Antigen B, which is controlled by allele IB
– Antigen O, which is controlled by allele i
Blood Type O A B AB
Genotype ii IAIA or IAi IBIB or IBi IAIB
Surface Antigen
O A B A and Bg
Allelic SeriesAllelic Series
• Dominance hierarchy will exist for• Dominance hierarchy will exist for multiple alleles– allelic series for ABO type
• IA = IB > i– allelic series for rabbit coat color alleles :
• C > cch > ch > c
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Allelic SeriesAllelic Series
• coat color in rabbitscoat color in rabbits– C (full coat color)
cch (chinchilla pattern of coat color)– cch (chinchilla pattern of coat color)• Partial defect in pigmentation
– ch (himalayan pattern of coat color)– c (himalayan pattern of coat color)• Pigmentation in only certain parts of the body
– c (albino)c (albino)• Lack of pigmentation
Allelic SeriesAllelic Series• Four alleles, c gene in rabbits ‐‐‐> six heterozygotes;
• C+ : completely dominantp y
• Cch (chinchila allele): partly dominant over the himalayan and albino alleleshimalayan and albino alleles
• Dominance relationship:
C+ > Cch > Ch > C
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• C gene – formation of black pigment in fur;C gene formation of black pigment in fur;
• Albino allele – nonfunctional allele = null =amorphic (completely recessive)=amorphic (completely recessive)
• Partly functional allele = hypomorphic
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Coat Colour in RabbitCoat Colour in Rabbit
Rabbit Genotype Phenotypeyp yp
Albino CC White hairs over the entire body
HimalayanChCh
Black hairs on the extremities; C C
white hairs everywhere else
ChinchillaCchCch
White hair with black tips on the bodybody
Wild‐typeC+C+
Coloured hairs over the entire bodyy
Lethal AllelesLethal Alleles• Essential genes are those that are absolutely
required for survivalq– The absence of their protein product leads to a lethal
phenotype• It is estimated that about 1/3 of all genes are essential for• It is estimated that about 1/3 of all genes are essential for
survival
• Nonessential genes are those not absolutely i d f i lrequired for survival
• A lethal allele is one that has the potential to cause the death of an organismcause the death of an organism – These alleles are typically the result of mutations in
essential genes– usually recessive, but can be dominant
Lethal AllelesLethal Alleles
• Example: agouti (coat color) in miceExample: agouti (coat color) in mice – agouti x agouti all agouti
yellow x yellow 2/3 yellow 1/3– yellow x yellow 2/3 yellow, 1/3 agouti
– agouti x yellow ½ yellow ½ agouti– agouti x yellow ½ yellow, ½ agouti
– Explanation: mutant yellow dominant over wt agouti and homozygous agouti lethal Mutantagouti and homozygous agouti lethal. Mutant allele always on (gain of function), deletion actually affects neighboring essential gene
YellowAy A+
YellowAy A+
SpermsA+ Ay
A+A+A+
(Gray‐Brown or A+Ay(Yellow)
Sperms
Aagouti)
AyA+Ay(Yellow)
AyAy(Embryonic lethality)
Eggs
y)
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Lethal Dominant MutationsLethal Dominant Mutations
• Both homozygous and heterozygous states areBoth homozygous and heterozygous states are lethal
• Generally very rare• Generally very rare
• Example: Huntington disease (humans)– Nervous and motor system degeneration
– Commonly begins to be exhibited after age forty (but can be much earlier)
• Children already born
• Afflicted persons are heterozygous (Hh)
Conditional MutationsConditional Mutations
• The ch allele is a temperature‐sensitiveThe ch allele is a temperature sensitiveconditional mutant – The enzyme is only functional at low temperatures– The enzyme is only functional at low temperatures
– Therefore, dark fur will only occur in cooler areas of the bodyof the body
OverdominanceOverdominance
• Overdominance is the phenomenon in whichOverdominance is the phenomenon in which a heterozygote is more vigorous than both of the corresponding homozygotesthe corresponding homozygotes
• Example• Example: – Sickle‐cell heterozygotes are resistant to malaria
d d l h b d– increased disease resistance in plant hybrids
Incomplete PenetranceIncomplete Penetrance
• In some instances a dominant allele is notIn some instances, a dominant allele is not expressed in a heterozygote individual
• Example = Polydactyly• Example = Polydactyly– Autosomal dominant trait
Aff d i di id l h ddi i l fi d/– Affected individuals have additional fingers and/or toes
A i l f th l d t l ll l i ll– A single copy of the polydactyly allele is usually sufficient to cause this condition
In some cases however individuals carry the– In some cases, however, individuals carry the dominant allele but do not exhibit the trait
I-2I-1
II-1 II-2 II-4 II-5II-3
III-4 III-5III-1 III-3III-2
I h i d h l d l ll l fIV-2 IV-3IV-1
Inherited the polydactyly allele fromhis mother and passed it on to adaughter and son;Does not exhibit the trait himselfDoes not exhibit the trait himselfeven though he is a heterozygote
Incomplete PenetranceIncomplete Penetrance • The term indicates that a dominant allele does not always “penetrate” into the phenotype of the individual
• The measure of penetrance is described at the population levelpopulation level– If 60% of heterozygotes carrying a dominant allele exhibit the trait allele, the trait is 60% penetrant, p
• Note:– In any particular individual the trait is either– In any particular individual, the trait is either penetrant or not
ExpressivityExpressivity
• Expressivity is the degree to which a trait isExpressivity is the degree to which a trait is expressed
• In the case of polydactyly the number of extra• In the case of polydactyly, the number of extra digits can vary
A ith l t di it h hi h– A person with several extra digits has high expressivity of this trait
A person with a single extra digit has low– A person with a single extra digit has low expressivity
ExpressivityExpressivity
• “Eyeless” mutation in Drosophila– Reduces eye size from a partial y preduction to complete elimination (average 0.25 to 0.50)
Penetrance & ExpressivityPenetrance & Expressivity
• The molecular explanation of expressivity andThe molecular explanation of expressivity and incomplete penetrance may not always be understoodunderstood
• In most cases, the range of phenotypes is thought to be due to influences of thethought to be due to influences of the– Environment
d/and/or
– Other genes (genetic background)
Environmental EffectsEnvironmental Effects• Temperature effectsTemperature effects
– Evening primrose produces red flowers at 23°C and white flowers at 18°C
– Siamese cats and Himalayan rabbits have darker fur on cooler areas of body (tail, feet, ears)
• Enzymes lose catalytic function at higher temperature• Enzymes lose catalytic function at higher temperature
• Temperature sensitive mutations– Mutant allele only expressed (phenotype) at [generally]Mutant allele only expressed (phenotype) at [generally] lower temperature
– ts phage mutants, restrictive and permissive temperatures
• Heat‐shock genes
Nutritional EffectsNutritional Effects• Nutritional mutationsNutritional mutations
– Prevent synthesis of nutrient molecules
– Auxotrophs
– Phenotype expressed or not depending upon the diet
• Phenylketonuria (PKU) – recessive disorder of amino acid metabolism– Loss of enzyme to metabolize phenylalanine
– Severe problems unless low Phe diet
• Galactosemia (very bad again) and lactose i t l ( l t)intolerance (unpleasant)…
Environmental Effects on the Expression of H GHuman Genes
• Pattern baldness – sex‐influencedPattern baldness sex influenced
• Both homo‐ and heterozygotes – bald patches (male);(male);
• Female – homozygotes – bald (thinning of the h i )hair)
• Relate to testosterone
GENE INTERACTIONSGENE INTERACTIONS
Epistatic Gene InteractionsEpistatic Gene Interactions• Gene interactions occur when two or more differentGene interactions occur when two or more different genes influence the outcome of a single trait
• Most morphological traits (height, weight, color) are p g ( g , g , )affected by multiple genes
• Epistasis describes situation between various alleles pof two genes
• Quantitative loci is a term to describe those loci controlling quantitatively measurable traits
• Pleiotropy describes situations where one gene affects multiple traits
EpistasisEpistasis• EpistasisEpistasis
– The effect of one gene pair (locus) masks or modifies the effect of another gene pair
• Examples– Recessive alleles at one locus override expression of alleles
h l ll l l id bat another locus. Alleles at 1st locus are said to be epistatic to the masked hypostatic alleles at the 2nd locus
– Allele(s) at one locus may require specific allele at anotherAllele(s) at one locus may require specific allele at another locus, these pairs are said to complement each other
Epistatic Gene InteractionsEpistatic Gene Interactions• examine cases involving 2 loci (genes) that each have 2 alleles g (g )
• Crosses performed can be illustrated in general by
– AaBb X AaBb– Where A is dominant to a and B is dominant to b
• If these two genes govern two different traitsA 9:3:3:1 ratio is predicted among the offspring– A 9:3:3:1 ratio is predicted among the offspring
– simple Mendelian dihybrid inheritance pattern
• If these two genes do affect the same trait the 9:3:3:1 ratio may be altered
– 9:3:4, or 9:7, or 9:6:1, or 8:6:2 or 12:3:1, or 13:3, or 15:1epistatic ratios– epistatic ratios
A Cross Producing a 9:7 ratioA Cross Producing a 9:7 ratio
White Variety White VarietyWhite Variety, CCpp
White Variety, ccPP
All purple, CcPp
F1
SELF-FERTILIZATION
9 C P : 3 C pp :3 ccP : 1 ccpp
F2 progeny
_ _ _pp _ pp
purple white
Duplicate Recessive Genes (9:7)Duplicate Recessive Genes (9:7)
When identical phenotypes are produced by both homozygous recessive genotypes, the F1 ratio becomes 9:7.
The genotype aaB-, A-bb & aabb produce one g yp , & pphenotype.
Both dominant alleles, when present together, complement each other & produce a differentcomplement each other & produce a different phenotype.
For example:Flower color of sweet peasA- codes for color pigmentB codes for color purpleb codes for color white
Duplicate Recessive Genes (9:7)Duplicate Recessive Genes (9:7)
P: AAbb (white) X aaBB (white)
F1: AaBb (purple)
F2 AB Ab aB abAB AABB,
purpleAABb,purple
AaBB,purple
AaBb,purplepurple purple purple purple
Ab AABb,purple
AAbb, white AaBb,purple
Aabb, white
B A BB A Bb BB hit Bb hitaB AaBB,purple
AaBb,purple
aaBB, white aaBb, white
ab AaBb, Aabb, white aaBb, white aabb, whitepurple
Epistatic Gene InteractionEpistatic Gene Interaction
• Complementary gene actionComplementary gene action– Enzyme C and enzyme P cooperate to make a product therefore they complement one anotherproduct, therefore they complement one another
Enzyme C Enzyme PEnzyme C Enzyme P
PurpleColorlessColorless Purple pigment
Colorless intermediate
Colorless precursor
Epistatic Gene InteractionEpistatic Gene Interaction• Epistasis describes the situation in which a gene masks the phenotypic effects of
another geneanother gene• Epistatic interactions arise because the two genes encode proteins that
participate in sequence in a biochemical pathway• If either loci is homozygous for a null mutation, none of that enzyme will be yg , y
made and the pathway is blocked
Enzyme C Enzyme PColorless precursor
Colorless intermediate
Purple pigment
y y
genotype cc genotype ppgenotype cc genotype pp
Colorless Colorless Purple Enzyme C Enzyme P
precursor intermediatep
pigment
A Cross Involving a Two-Gene Interaction Can Still P d 9 3 3 1 tiProduce a 9:3:3:1 ratio
• Inheritance of comb morphology in chickenInheritance of comb morphology in chicken– First example of gene interaction
William Bateson and Reginald Punnett in 1906– William Bateson and Reginald Punnett in 1906
– Four different comb morphologies:
R P W l t & Si l– Rose, Pea, Walnut & Single
The crosses of Bateson and Punnett
Rose combWyandotte
Pea combBrahmaWyandotte
RRppBrahmarrPP
RP Rp rP rpAll Walnut,
RrPpF1
RP Rp rP rp
RPRRPPwalnut
RRPpWalnut
RrPPWalnut
RrPpWalnut
RRP RR R P R
SELF-FERTILIZATIONRp
RRPpWalnut
RRppRose
RrPpWalnut
RrppRose
rPRrPP
W lRrPp
W lrrPPP
rrPpP
F2 progeny
rPWalnut Walnut Pea Pea
rpRrPp
WalnutRrppRose
rrPpPea
rrppSingle
The crosses of Bateson and PunnettThe crosses of Bateson and Punnett
• F2 generation consisted of chickens with fourF2 generation consisted of chickens with four types of combs– 9 walnut : 3 rose : 3 pea : 1 single– 9 walnut : 3 rose : 3 pea : 1 single
• Bateson and Punnett reasoned that comb morphology is determined by two differentmorphology is determined by two different genes
R ( b) i d i– R (rose comb) is dominant to r
– P (pea comb) is dominant to p
– R and P are codominant (walnut comb)
– rrpp produces single comb
Duplicate Dominant Gene (15:1)The 9:3:3:1 ratio is modified if the dominant alleles of both loci each produce the
same phenotype without cumulative effect.
Duplicate Dominant Gene (15:1)same phenotype without cumulative effect.
For example:Flower color of peas
bb d f l hitaabb codes for color whiteany other combination produce color red
P: AAbb (red) X aaBB (white) ( ) ( )F1: AaBb (red)F2 AB Ab aB ab
A AABB red AABb red AaBB red AaBb redAB
AABB, red AABb, red AaBB, red AaBb, red
Ab AABb, red AAbb, red AaBb, red Aabb, red
aB AaBB red AaBb red aaBB red aaBb redaB AaBB, red AaBb, red aaBB, red aaBb, red
ab AaBb, red Aabb, red aaBb, red aabb, white
Gene InteractionGene Interaction
• Duplicate gene actionDuplicate gene action– Enzyme 1 and enzyme 2 are redundantredundant
– They both make product C, therefore they duplicatetherefore they duplicate each other
Dominant Epistasis (12:3:1)Dominant Epistasis (12:3:1)• When the dominant allele (A) produces a certain
phenotype regardless of the allele condition of another locus (B), A is said to be epistatic to B.The dominant allele A is able to express itself in theThe dominant allele A is able to express itself in the presence of either B or b.Only when the genotype of the individual is homozygous recessive (aa), then B or b can be expressed.A B & A bb produce the same phenotype;A-B- & A-bb produce the same phenotype;
• aaB- & aabb produce 2 additional phenotypes.
Dominant Epistasis (12:3:1)Dominant Epistasis (12:3:1)For example:Coat colors of dogsCoat colors of dogsI- inhibit coat color pigment / expressionB represents black color coatb represents brown color coatb represents brown color coatP: IiBb (white) X IiBb (white)F1: IiBb
F2 IB Ib iB ibIB IIBB,
whiteIIBb,white
IiBB,white
IiBb,white
Ib IIBb,white
IIbb,white
IiBb,white
Iibb,white
iB IiBB,white
IiBb,white
iiBB,black
iiBb,black
ib IiBb,white
Iibb,white
iiBb,black
iibb,brown
Recessive Epistasis (9:3:4)Recessive Epistasis (9:3:4)
If the recessive genotype at locus A (eg: aa) suppresses the expression of alleles at B locus, locus A exhibit recessive epistasis over locus B.
The alleles in locus B can only be expressed with the presence of dominant alleles at locus A.
Genotypes A-B- & A-bb produce 2 additional phenotypes.
For example:For example:Flower color of peasA- codes for color pigmentB codes for color purpleb codes for color red
•
Recessive Epistasis (9:3:4)Recessive Epistasis (9:3:4)
P: AAbb (red) X aaBB (white)P: AAbb (red) X aaBB (white) F1: AaBb (purple)
F2 AB Ab aB abAABB AABb AaBB AaBbAB AABB,purple
AABb,purple
AaBB,purple
AaBb,purple
Ab AABb,purple
AAbb, red AaBb,purple
Aabb, redpurple purple
aB AaBB,purple
AaBb,purple
aaBB,white
aaBb,white
ab AaBb,purple
Aabb, red aaBb,white
aabb,white
Duplicate Genes with Cumulative Effect (9 6 1)(9:6:1)
Occur when dominant allele (homozygous or heterozygous) at either locus (but not both) produces the same phenotype.Genotypes A-bb & aaB- produce one unit each and therefore have the same phenotype.Genotype aabb produces no pigment but in genotype A-B- the effect is cumulative and 2 units of phenotypes are produced.
For example:Color of wheat kernelsR B produce red colorR-B- produce red colorrrbb produce white colorAny other combination produces brown color
•
P: RRBB (red) X rrbb (white)F1: RrBb (red)
F2 RB Rb rB rbRRBB RRBb RrBB RrBb redRB RRBB,red
RRBb,red
RrBB,red
RrBb, red
Rb RRBb, RRbb, RrBb, Rrbb,Rb ,red
,brown
,red
,brown
rB RrBB,d
RrBb,d
rrBB,b
rrBb,brB red red brown brown
rb RrBb,red
Rrbb,brown
rrBb,brown
rrbb,whitered brown brown white
Dominant and Recessive Interaction (13:3)Only two F2 phenotypes result when a dominant genotype at 1 locus
(A ) d th i t t th (bb) d th
Dominant and Recessive Interaction (13:3)
(A-) and the recessive genotype at another (bb) produce the same phenotypic effect.
Genotype A-B-, aaB- & aabb produce one phenotype and genotype yp p p yp g ypA-bb produce another in the ratio 13:3.
F2 AB Ab aB abAB AABB,
whiteAABb,white
AaBB,white
AaBb,white
Ab AABb,hit
AAbb, red AaBb,hit
Aabb, redwhite white
aB AaBB,white
AaBb,white
aaBB,white
aaBb,white
ab AaBb,white
Aabb, red aaBb,white
aabb,white
Dominant and Recessive Interaction (13:3)
Only two F2 phenotypes result when a dominant genotype at 1 locus (A-) and the recessive genotype at another (bb) produce the same phenotypic effectproduce the same phenotypic effect.
Genotype A-B-, aaB- & aabb produce one phenotype and genotype A-bb produce another in the ratio 13:3.genotype A bb produce another in the ratio 13:3.
Dominant and Recessive Interaction (13:3)For example:
Flower color of peasA bb d f l d
( )
A-bb codes for color redAny other combination codes for color white
P: AAbb (white) X aaBB (white) ( ) ( )F1: AaBb (white)
F2 AB Ab aB abF2 AB Ab aB abAB AABB,
whiteAABb, white
AaBB, white
AaBb, white
Ab AABb AaBbAb AABb, white AAbb, red AaBb,
white Aabb, red
aB AaBB, white
AaBb, white
aaBB, white
aaBb, white
ab AaBb, white Aabb, red aaBb,
whiteaabb, white
Summary of Epistatic Ratios
Genotypes A-B- A-bb aaB- aabb
Summary of Epistatic Ratios
Genotypes A B A bb aaB aabb
Classical ratio 9 3 3 1
Dominant epistasis 12 3 1pRecessive epistasis 9 3 4Duplicate genes with cumulative 9 6 1effect 9 6 1
Duplicate dominant genes 15 1
Duplicate recessive genes 9 7Dominant and recessive interaction 13 3interaction
Examples of Epistatic Cases
Organism CharacterF2 Phenotypes Modified
ratio9/16 3/16 3/16 1/16
p p
ratio9/16 3/16 3/16 1/16
MouseCoat colour
Agouti albino Black Albino 9:3:4
Squash Colour White Yellow Green 12:3:1
PeaFlower colour
Purple White 9:7
SquashFruit shape
Disc Sphere Long 9:6:1
Chicken Colour White Coloured White 13:3Chicken Colour White Coloured White 13:3
ReferencesReferences
• Snustad DP, Simmons, MJ (2010) Principles of Genetics Fifth , , ( ) pEd. John Wiley & Sons, Inc., USA.
• Klug WS, Cummings MR, Spencer CA, Palladino MA (2012) C t f G ti 10th Ed P C lif iConcepts of Genetics. 10th Ed. Pearson, California.
• Hartwell LH, Hood L, Goldberg ML,Reynolds AE, Silver LM (2011) Genetics: From Genes to Genomes. 4th Ed. McGraw‐Hill ( )Companies, Inc.,NY