fa2014 rr index card
TRANSCRIPT
![Page 1: FA2014 RR Index Card](https://reader030.vdocument.in/reader030/viewer/2022021322/55cf96ff550346d0338f2e55/html5/thumbnails/1.jpg)
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"Butterfly" facial rash anRaynaud phenomenon in
young female. Disease/D
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Systemic lupus
erythematosus
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"Cherry-red spots" on
macula. Disease/Dx?
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Tay-Sachs (gangliosideaccumulation) or Nieman
Pick (sphingomyelinaccumulation), centralretinal artery occlusion
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"Strawberry tongue".
Disease/Dx?
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Scarlet fever, Kawasakidisease, toxic shock
syndrome
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"Worst headache of my
life". Disease/Dx?
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Subarachnoid hemorrha
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1° amenorrhea.
Association?
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Turner syndrome (45,XO
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1° bone tumor (adults)
Association?
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Multiple myeloma
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1° hyperaldosteronism
Association?
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Adenoma of adrenal cort
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1° hyperparathyroidism
Association?
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Adenomas, hyperplasia
carcinoma
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1° liver cancer.
Association?
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Hepatocellular carcinom
(chronic hepatitis,cirrhosis,
hemochromatosis, α1-antitrypsin deficiency)
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2° hyperparathyroidism
Association?
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Hypocalcemia of chroni
kidney disease
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Abdominal pain, asciteshepatomegaly.Disease/Dx?
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Budd-Chiari syndrome(posthepatic venous
thrombosis)
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Achilles tendon xanthom
Disease/Dx?
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Familialhypercholesterolemia ( d
LDL receptor signaling
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Actinic (solar) keratosis
Association?
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Precursor to squamous c
carcinoma
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Acute gastric ulcerassociated with CNS inju
Association?
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Cushing ulcer (incintracranial pressure
stimulates vagal gastricsecretion)
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Acute gastric ulcerassociated with severe
burns. Association?
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Curling ulcer (greatly reduced plasma volume
results in sloughing of gastric mucosa)
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Adrenal hemorrhage,hypotension, DIC.
Disease/Dx?
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Waterhouse-Friderichsesyndrome
(meningococcemia)
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Alternating areas of transmural inflammatio
and normal colon. Association?
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Skip lesions (Crohn
disease)
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Aneurysm, dissecting.
Association?
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Hypertension
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Anterior "drawer sign" (+
Disease/Dx?
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Anterior cruciate ligame
injury
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Aortic aneurysm,abdominal and descendin
aorta. Association?
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Atherosclerosis
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Aortic aneurysm, arch.
Association?
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3° syphilis (syphiliticaortitis), vasa vasorum
destruction
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Aortic aneurysm,
ascending. Association?
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Marfan syndrome(idiopathic cystic media
degeneration)
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Arachnodactyly, lensdislocation, aortic
dissection, hyperflexibl joints. Disease/Dx?
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Marfan syndrome (fibrill
defect)
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Athlete with polycythemi
Disease/Dx?
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2° to erythropoietin
injection
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Atrophy of the mammilla
bodies. Association?
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Wernicke encephalopath
(thiamine deficiency causing ataxia,
ophthalmoplegia, andconfusion)
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Autosplenectomy (fibrosand shrinkage).
Association?
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Sickle cell anemia
(hemoglobin S)
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Back pain, fever, nightsweats, weight loss.
Disease/Dx?
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Pott disease (vertebral T
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Bacteria associated withgastritis, peptic ulcer
disease, and stomachcancer. Association?
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H. pylori
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Bacterial meningitis (adu
and elderly). Association
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Streptococcus pneumoni
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Bacterial meningitis(newborns and kids).
Association?
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Group B
streptococcus/E.coli(newborns), S.
pneumoniae/ Neisseriameningitidis (kids)
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Benign melanocytic nevu
Association?
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Spitz nevus (most commo
in 1st two decades)
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Bilateral hilar adenopath
uveitis. Disease/Dx?
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Sarcoidosis (noncaseatin
granulomas)
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Bleeding disorder withGpIb deficiency.
Association?
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Bernard-Soulier syndrom(defect in platelet adhesi
to von Willebrand factor
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Blue sclera. Disease/Dx
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Osteogenesis imperfect
(type I collagen defect)
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Bluish line on gingiva.
Disease/Dx?
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Burton line (lead
poisoning)
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Bone pain, boneenlargement, arthritis.
Disease/Dx?
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Paget disease of bone ( inosteoblastic and
osteoclastic activity)
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Bounding pulses, diastolheart murmur, head
bobbing. Disease/Dx?
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Aortic regurgitation
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Brain tumor (adults).
Association?
Supratentorial: metastas
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Supratentorial: metastas
> astrocytoma (includinglioblastoma multiforme
meningioma >schwannoma
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Brain tumor (kids).
Association?
Infratentorial:
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Infratentorial:
medulloblastoma(cerebellum) or
supratentorial:craniopharyngioma
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Breast cancer. Associatio
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Infiltrating ductal
carcinoma
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Breast mass. Association
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Fibrocystic change,carcinoma (in
postmenopausal women
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Breast tumor (benign). Association?
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Fibroadenoma
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Cafe -au-lait spots, Lischnodules (iris hamartoma
Disease/Dx?
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Neurofibromatosis type (+ pheochromocytoma
optic gliomas)
Cafe -au-lait spots
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Cafe-au-lait spots,
polyostotic fibrousdysplasia, precocious
puberty, multiple endocriabnormalities. Disease/D
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McCune-Albrightsyndrome (mosaic G-
protein signaling mutatio
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Calf pseudohypertrophyDisease/Dx?
l d h (
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Muscular dystrophy (mocommonly Duchenne): X
linked recessive deletion dystrophin gene
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Cardiac 1° tumor (kids) Association?
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Rhabdomyoma, often seein tuberous sclerosis
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Cardiac manifestation olupus. Association?
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Libman-Sacks endocardi(nonbacterial, affecting
both sides of mitral valv
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Cardiac tumor (adults) Association?
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Metastasis, 1° myxoma (4left to right atrium; "bal
and valve")
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Cerebellar tonsillarherniation. Association
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Chiari II malformation
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Chest pain on exertionDisease/Dx?
A i ( t bl ith
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Angina (stable: withmoderate exertion;
unstable: with minimalexertion)
Chest pain pericardial
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Chest pain, pericardialeffusion/friction rub,
persistent fever followinMI. Disease/Dx?
Dressler syndrome
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y
(autoimmune-mediatedpost-MI fibrinous
pericarditis, 1-12 weeksafter acute episode)
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Child uses arms to stand from squat. Disease/Dx
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Gowers sign (Duchennemuscular dystrophy)
Child with fever later
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Child with fever later
develops red rash on facthat spreads to body.
Disease/Dx?
"Slapped cheeks"
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Slapped cheeks
(erythemainfectiosum/fifth disease
parvovirus B19)
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Chorea, dementia, caudadegeneration. Disease/D
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Huntington disease(autosomal dominant CA
repeat expansion)
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Chronic arrhythmia. Association?
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Atrial fibrillation(associated with high ris
of emboli)
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Chronic atrophic gastrit(autoimmune).
Association?
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Predisposition to gastricarcinoma (can also cau
pernicious anemia)
Chronic exercise
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intolerance with myalgiafatigue, painful cramps
myoglobinuria.Disease/Dx?
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McArdle disease (musclglycogen phosphorylase
deficiency)
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Clear cell adenocarcinomof the vagina. Association
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DES exposure in utero
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Cold intolerance.Disease/Dx?
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Hypothyroidism
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Compression fracture. Association?
Osteoporosis (type I:
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Osteoporosis (type I:
postmenopausal womantype II: elderly man or
woman)
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Condition: Absenceseizures. Tx?
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Ethosuximide
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Condition: Acute goutattack. Tx?
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NSAIDs, colchicine
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Condition: Acutepromyelocytic leukemia
(M3). Tx?
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All-trans retinoic acid
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Condition: ADHD. Tx?
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Methylphenidate,amphetamines
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Condition: Alcohol usedisorder. Tx?
AA + disulfiram,
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,
naltrexone, or acamprosafor patient. Al-Anon for
patient's family
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Condition: Alcohol withdrawal. Tx?
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Benzodiazepines
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Condition: Anorexia. Tx
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Nutrition, psychotherap
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Condition: Anticoagulatiduring pregnancy. Tx?
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Heparin
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Condition: Arrhythmia idamaged cardiac tissue
Tx?
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Class IB antiarrhythmic(lidocaine, mexiletine,
tocainide)
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Condition: B12 deficiencTx?
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Vitamin B12supplementation (work u
cause with Schilling test
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Condition: Benign prostahyperplasia. Tx?
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Tamsulosin, finasteride
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Condition: Bipolardisorder. Tx?
Lithium, valproate,
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carbamazepine,lamotrigine (mood
stabilizers)
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Condition: Breast cancerpostmenopausal woman
Tx?
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Aromatase inhibitor(anastrozole)
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Condition: Buerger diseaTx?
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Smoking cessation
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Condition: Bulimianervosa. Tx?
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SSRIs
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Condition: Candidaalbicans. Tx?
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Amphotericin B (systeminystatin (oral thrush),
azoles (vaginitis)
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Condition: Carcinoidsyndrome. Tx?
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Octreotide
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Condition: Chlamydiatrachomatis. Tx?
Doxycycline (+ ceftriaxon
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for gonorrhea coinfectionerythromycin eye drops
(prophylaxis in infants)
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Condition: Chronic goutTx?
Probenecid
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(underexcretor),allopurinol (overproduce
febuxostat
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Condition: Chronichepatitis. Tx?
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IFN-α
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Condition: Chronicmyelogenous leukemia. T
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Imatinib
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Condition: Clostridium botulinum. Tx?
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Antitoxin
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Condition: Clostridiumdifficile. Tx?
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Oral metronidazole; if refractory, oral vancomyc
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Condition: Clostridiumtetani. Tx?
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Antitoxin + vaccine boost+ diazepam
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Condition: CMV. Tx?
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Ganciclovir
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Condition: Crohn diseasTx?
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Corticosteroids, infliximamethotrexate, azathiopri
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Condition: Cryptococcuneoformans. Tx?
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Fluconazole (prophylaxis AIDS patients)
Condition:
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Cyclophosphamide-induced hemorrhagic
cystitis. Tx?
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Mesna
di i i
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Condition: Depression. T
(fi li )
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SSRIs (first-line)
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DDAVP (central);
h d hl hi id
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hydrochlorothiazide,indomethacin, amilorid
(nephrogenic)
C di i Di b
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Condition: Diabetesmellitus type 1. Tx?
Dietary intervention (low) i li
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sugar) + insulin
replacement
C di i Di b
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Condition: Diabetesmellitus type 2. Tx?
Dietary intervention, orah l i d i l
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hypoglycemics, and insul
(if refractory)
C diti Di b ti
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Condition: Diabeticketoacidosis. Tx?
Fl id i li K
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Fluids, insulin, K+
C diti E t i
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Condition: EnterococciTx?
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C diti ER b t
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Condition: ER+ breastcancer. Tx?
T if
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Tamoxifen
C diti E til
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Condition: Erectiledysfunction. Tx?
Sild fil d fil
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Sildenafil, vardenafil
Condition: Ethylenel l/ th l
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glycol/methanolintoxication. Tx?
Fomepi ole (alcohol
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Fomepizole (alcoholdehydrogenase inhibitor
Condition: Generalized
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Condition: Generalizedanxiety disorder. Tx?
Buspirone
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Buspirone
Condition: Granulomatowith polyangiitis
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with polyangiitis(Wegener). Tx?
Cyclophosphamide
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Cyclophosphamide,corticosteroids
Condition: Haemophilu
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Condition: Haemophiluinfluenzae (B). Tx?
Rifampin (prophylaxis)
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Rifampin (prophylaxis)
Condition: Heparin toxic
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Condition: Heparin toxic(acute). Tx?
Protamine sulfate
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Protamine sulfate
Condition: HER2/neu+
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Condition: HER2/neu+ breast cancer. Tx?
Trastuzumab
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Trastuzumab
Condition:
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Condition:Hyperaldosteronism. Tx
Spironolactone
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Spironolactone
Condition:
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Condition:Hypercholesterolemia. T
Statin (first-line)
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Statin (first-line)
Condition:
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Condition:Hypertriglyceridemia. Tx
Fibrate
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Fibrate
Condition: Immediatel
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Condition: Immediateanticoagulation. Tx?
Heparin
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Heparin
Condition: Infertility Tx
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Condition: Infertility. Tx
Leuprolide GnRH( l il ) l i h
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Leuprolide, GnRH(pulsatile), clomiphene
Condition: Influenza Tx
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Condition: Influenza. Tx
Rimantadine oseltamiv
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Rimantadine, oseltamiv
Condition: Legionellahil T ?
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Condition: Legionellapneumophila. Tx?
Erythromycin
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Erythromycin
Condition: Long-termti l ti T ?
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Condition: Long termanticoagulation. Tx?
Warfarin
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Warfarin
Condition: Malaria. Tx?
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Condition: Malaria. Tx?
Chloroquine/mefloquin
(for blood schizont),i i (f li
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(for blood schizont),primaquine (for liver
hypnozoite)
Condition: Malignanth perthermia T ?
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Condition: Malignanthyperthermia. Tx?
Dantrolene
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Dantrolene
Condition: Medicalabortion Tx?
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Condition: Medicalabortion. Tx?
Mifepristone
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Mifepristone
Condition: Migraine. Tx
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C g
Sumatriptan
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p
Condition: MRSA. Tx?
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Vancomycin
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y
Condition: Multiplesclerosis Tx?
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psclerosis. Tx?
β-interferon,
immunosuppression,
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pp ,natalizumab
Condition: Mycobacteriutuberculosis Tx?
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ytuberculosis. Tx?
RIPE (rifampin, INH,pyrazinamide ethambuto
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( p , ,pyrazinamide, ethambuto
Condition: Neisseriagonorrhoeae Tx?
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gonorrhoeae. Tx?
Ceftriaxone (add
doxycycline to cover like
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y yconcurrent Chlamydia)
Condition: Neisseriameningitidis Tx?
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meningitidis. Tx?
Penicillin/ceftriaxone,rifampin (prophylaxis)
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/rifampin (prophylaxis)
Condition: Neural tubedefect prevention Tx?
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defect prevention. Tx?
Prenatal folic acid
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Condition:Osteomalacia/rickets. Tx
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Osteomalacia/rickets. Tx
Vitamin Dsupplementation
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supplementation
Condition: OsteoporosisTx?
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Tx?
Bisphosphonates; calciu
and vitamin Dl i
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supplementation
Condition: Patent ductuarteriosus. Tx?
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arteriosus. Tx?
Indomethacin
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Condition:Pheochromocytoma. Tx
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y
α-antagonists (e.g.,phenoxybenzamine)
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p y )
Condition: Pneumocysti jirovecii. Tx?
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j
TMP-SMX (prophylaxis AIDS patient)
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p )
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Bromocriptine (dopaminagonists)
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g )
Condition: Prostate
cancer/uterine fibroidsT ?
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Tx?
Leuprolide, GnRH(continuous)
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Condition: Prostatecarcinoma. Tx?
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Flutamide
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Condition: Pseudomonaaeruginosa. Tx?
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Antipseudomonalpenicillin + aminoglycosi
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Condition: Pulmonary
arterial hypertension(idiopathic) Tx?
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(idiopathic). Tx?
Sildenafil, bosentan,epoprostenol
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Condition: Rickettsiarickettsii. Tx?
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Doxycycline,
chloramphenicol(associated with aplasti
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anemia)
Condition: Ringworminfections. Tx?
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Terbinafine, griseofulvinimidazole
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Condition: Schizophreni(negative symptoms). Tx
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Condition: Schizophreni(positive symptoms). Tx
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D2 receptor antagonist
(e.g., 1st- and 2nd-generation antipsychotic
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generation antipsychotic
Condition: SIADH. Tx?
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Condition: Sickle cellanemia. Tx?
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Hydroxyurea (inc fetalhemoglobin)
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Condition: Sporothrixschenckii. Tx?
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Oral potassium iodide
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Condition: Stable anginaTx?
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Sublingual nitroglycerin
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Condition: Staphylococcaureus. Tx?
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MSSA: nafcillin, oxacillidicloxacillin
(antistaphylococcalpenicillins); MRSA:
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p );
vancomycin
Condition: Streptococcu bovis. Tx?
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Penicillin prophylaxis;
evaluation for colon cancif linked to endocarditis
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Condition: Streptococcupneumoniae. Tx?
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Penicillin/cephalospori(systemic infection,
pneumonia), vancomyci
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(meningitis)
Condition: Streptococcupyogenes. Tx?
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Penicillin prophylaxis
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Condition: Temporalarteritis. Tx?
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High-dose steroids
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Condition: Tonic-clonicseizures. Tx?
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Phenytoin, valproate,carbamazepine
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Condition: Toxoplasmagondii. Tx?
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Sulfadiazine +pyrimethamine
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Condition: Treponemapallidum. Tx?
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Penicillin
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Condition: Trichomona vaginalis. Tx?
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Metronidazole (patient apartner)
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Condition: Trigeminal
neuralgia (tic douloureuxTx?
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Carbamazepine
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Condition: Ulcerativecolitis. Tx?
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5-ASA, infliximab,colectomy
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Condition: UTIprophylaxis. Tx?
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TMP-SMX
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Condition: Warfarintoxicity. Tx?
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Fresh frozen plasma
(acute), vitamin K (chronic)
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Congenital adrenal
hyperplasia, hypotension Association?
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21-hydroxylase deficienc
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Congenital cardiacanomaly. Association?
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VSD
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Congenital conjugated
hyperbilirubinemia (blacliver). Association?
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Dubin-Johnson syndrom(inability of hepatocytes
secrete conjugated bilirubin into bile)
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b b b )
Conjugate lateral gaze
palsy, horizontal diplopiDisease/Dx?
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Internuclearophthalmoplegia (damag
to MLF; bilateral [multipsclerosis], unilateral
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[stroke])
Constrictive pericarditis Association?
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TB (developing world); S(developed world)
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Continuous "machine-lik
heart murmur.Disease/Dx?
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PDA (close with
indomethacin; open ormaintain with misoprosto
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Coronary artery involved
thrombosis. Association
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LAD > RCA > LCA
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Cretinism. Association?
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Iodine
deficit/hypothyroidism
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Cushing syndrome.
Association?
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* Iatrogenic Cushing (from corticostertherapy)* Adrenocortical adenoma (secretes
excess cortisol)* ACTH-secreting pituitary adenoma * Paraneoplastic Cushing (due to ACT
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secretion by tumors)
Cutaneous/dermal edem
due to connective tissuedeposition. Disease/Dx
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Myxedema (caused by
hypothyroidism, Gravesdisease [pretibial])
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Cyanosis (early; less
common). Association?
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Tetralogy of Fallot,
transposition of great vessels, truncus arteriosu
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Cyanosis (late; more
common). Association?
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VSD, ASD, PDA
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Dark purple skin/mouth
nodules in a patient with AIDS. Disease/Dx?
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Kaposi sarcoma, associat
with HHV-8
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Death in CML.
Association?
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Blast crisis
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Death in SLE. Associatio
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Lupus nephropathy
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Deep, labored
breathing/hyperventilatioDisease/Dx?
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Kussmaul respirations
(diabetic ketoacidosis)
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Dementia. Association?
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Alzheimer disease, multip
infarcts
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Demyelinating disease i
young women. Associatio
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Multiple sclerosis
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Dermatitis, dementia,
diarrhea. Disease/Dx?
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Pellagra (niacin [vitami
B3] deficiency)
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Severe sepsis, obstetriccomplications, cancer,
burns, trauma, majorsurgery
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Dietary deficit.
Association?
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Iron
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Dilated cardiomyopathy
edema, alcoholism ormalnutrition. Disease/D
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Wet beriberi (thiamine
[vitamin B1] deficiency
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Diverticulum in pharynx
Association?
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Zenker diverticulum
(diagnosed by bariumswallow)
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Dog or cat bite resulting
infection. Disease/Dx?
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Pasteurella multocida
(cellulitis at inoculationsite)
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Dry eyes, dry mouth,
arthritis. Disease/Dx?
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Sjo gren syndrome
(autoimmune destructioof exocrine glands)
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Dysphagia (esophageal webs), glossitis, iron
deficiency anemia.Disease/Dx?
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Plummer-Vinson syndrom(may progress to
esophageal squamous cecarcinoma)
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Ejection click. Associatio
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Aortic/pulmonic stenosi
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Elastic skin, hypermobili
of joints. Disease/Dx?
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Ehlers-Danlos syndrom
(type III collagen defect
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Enlarged, hard left
supraclavicular node.Disease/Dx?
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Virchow node (abdomin
metastasis)
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Erythroderma,lymphadenopathy,
hepatosplenomegaly,atypical T cells.
Disease/Dx?
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Disease/Dx?
Mycosis fungoides(cutaneous T-cell lymphom
or Se zary syndrome (mycofungoides + malignant T cein blood)
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Esophageal cancer.
Association?
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Squamous cell carcinom
(worldwide);adenocarcinoma (U.S.)
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Facial muscle spasm upo
tapping. Disease/Dx?
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Chvostek sign
(hypocalcemia)
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Fat, female, forty, and
fertile. Disease/Dx?
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Cholelithiasis (gallstone
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Fever, chills, headachemyalgia following
antibiotic treatment forsyphilis. Disease/Dx?
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Jarisch-Herxheimerreaction (rapid lysis of
spirochetes results in toxrelease)
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Fever, cough,
conjunctivitis, coryza,diffuse rash. Disease/Dx
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Measles
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Fever, night sweats, weig
loss. Disease/Dx?
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B symptoms (staging) o
lymphoma
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Fibrous plaques in softtissue of penis.
Disease/Dx?
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Peyronie disease
(connective tissue disorde
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Food poisoning (exotoxi
mediated). Association?
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S. aureus, B. cereus
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Glomerulonephritis
(adults). Association?
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Berger disease (IgA
nephropathy)
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Gout, intellectual disabiliself-mutilating behavior
a boy. Disease/Dx?
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Lesch-Nyhan syndrome(HGPRT deficiency, X-
linked recessive)
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Green-yellow rings arounperipheral cornea.
Disease/Dx?
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Kayser-Fleischer rings(copper accumulation fro
Wilson disease)
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Gynecologic malignancy
Association?
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Endometrial carcinoma(most common in U.S.)
cervical carcinoma (moscommon worldwide)
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Hamartomatous GI polyphyperpigmentation of
mouth/feet/hands.Disease/Dx?
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Peutz-Jeghers syndrom(inherited, benign
polyposis can cause bowobstruction; inc cancer
risk, mainly GI)
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risk, mainly GI)
Heart murmur, congenit
Association?
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Mitral valve prolapse
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Heart valve in bacterial
endocarditis. Association
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Mitral > aortic (rheumatfever), tricuspid (IV dru
abuse)
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Helminth infection (U.S
Association?
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Enterobius vermicularis
Ascaris lumbricoides
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Hematoma—epidural.
Association?
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Rupture of middlemeningeal artery (traum
lentiform shaped)
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Hematoma—subdural.
Association?
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Rupture of bridging vein
(crescent shaped)
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Hemochromatosis.
Association?
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Multiple blood transfusionor hereditary HFE mutatio(can result in CHF, "bronzediabetes," and increased risof hepatocellular carcinom
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Hepatocellular carcinom
Association?
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Cirrhotic liver (associate with hepatitis B and C an
with alcoholism)
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Hepatosplenomegaly,osteoporosis, neurologisymptoms. Disease/Dx
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Gaucher disease(glucocerebrosidase
deficiency)
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Hereditary bleeding
disorder. Association?
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von Willebrand disease
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Hereditary harmless
jaundice. Association?
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Gilbert syndrome (benigcongenital unconjugate
hyperbilirubinemia)
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Hereditary nephritis,sensorineural hearing los
cataracts. Disease/Dx?
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Alport syndrome (mutati
in collagen IV)
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Ankylosing spondylitisreactive arthritis, ulcerati
colitis, psoriatic arthriti
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HLA-DR3 or -DR4.
Association?
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Diabetes mellitus type 1
rheumatoid arthritis, SL
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Holosystolic murmur.
Association?
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VSD, tricuspidregurgitation, mitral
regurgitation
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Hypercoagulability,endothelial damage, bloo
stasis. Association?
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Virchow triad (results in
venous thrombosis)
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Hyperphagia,hypersexuality,
hyperorality, hyperdociliDisease/Dx?
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Klu ver-Bucy syndrome
(bilateral amygdala lesio
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Hyperreflexia, hypertoniBabinski sign present.
Disease/Dx?
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UMN damage
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Hypertension, 2°.
Association?
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Renal disease
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Hypoparathyroidism.
Association?
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Accidental excision durin
thyroidectomy
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Hypopituitarism.
Association?
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Pituitary adenoma (usua
benign tumor)
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Hyporeflexia, hypotoniaatrophy, fasciculations
Disease/Dx?
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LMN damage
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Hypoxemia, polycythemi
hypercapnia. Disease/Dx
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"Blue bloater" (chronic bronchitis: hyperplasia o
mucous cells)
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Indurated, ulcerated
genital lesion. Disease/D
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Nonpainful: chancre (1
syphilis, Treponemapallidum) Painful, with
exudate: chancroid(Haemophilus ducreyi)
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Infant with cleft lip/palat
microcephaly orholoprosencephaly,
polydactyly, cutis aplasiDisease/Dx?
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Patau syndrome (trisom
13)
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Infant with failure to
thrive,hepatosplenomegaly, an
neurodegeneration.Disease/Dx?
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Niemann-Pick disease(genetic sphingomyelina
deficiency)
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Infant with hypoglycemifailure to thrive, and
hepatomegaly.Disease/Dx?
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Cori disease (debranchin
enzyme deficiency) or VoGierke disease (glucose-6
phosphatase deficiency, mosevere)
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Infant with microcephal
rocker-bottom feet,clenched hands, and
structural heart defect.Disease/Dx?
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Edwards syndrome
(trisomy 18)
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Infection 2° to blood
transfusion. Association
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Hepatitis C
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Infections in chronicgranulomatous disease
Association?
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Staphylococcus aureus, E
coli, Aspergillus (catalase
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Intellectual disability.
Association?
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Down syndrome, fragile
syndrome
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Jaundice, palpabledistended non-tender
gallbladder. Disease/Dx
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Courvoisier sign (distal
obstruction of biliary tre
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Kidney stones.
Association?
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Calcium = radiopaque
Struvite (ammonium) =radiopaque (formed by ureaseorganisms such as Proteus
vulgaris or Staphylococcus);Uric acid = radiolucent
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Labs: "Apple core" lesioon abdominal x-ray.
Disease/Dx?
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Colorectal cancer (usual
left-sided)
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Labs: "Bamboo spine" on
ray. Disease/Dx?
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Ankylosing spondylitis(chronic inflammatory
arthritis: HLA-B27)
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Labs: "Boot-shaped" hea
on x-ray. Disease/Dx?
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Tetralogy of Fallot, RVH
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Labs: "Brown" tumor o
bone. Disease/Dx?
H th idi
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Hyperparathyroidism o
osteitis fibrosa cystica(deposited hemosiderin
from hemorrhage gives brown color)
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Labs: "Chocolate cyst" o
ovary. Disease/Dx?
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Endometriosis (frequent
involves both ovaries)
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Labs: "Hair on end" (crewcut) appearance on x-ray
Disease/Dx?
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β-thalassemia, sickle ceanemia (marrow
expansion)
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Labs: "Honeycomb lungon x-ray or CT.
Disease/Dx?
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Interstitial pulmonary
fibrosis
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Labs: "Lead pipe"appearance of colon on
barium enema x-ray.Disease/Dx?
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Ulcerative colitis (loss o
haustra)
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Labs: "Lumpy bumpy"appearance of glomeruli
immunofluorescence.Disease/Dx?
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Poststreptococcalglomerulonephritis
(immune complexdeposition of IgG and C3
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Labs: "Nutmeg"appearance of liver.
Disease/Dx?
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Chronic passive congestiof liver due to right hear
failure
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Labs: "Onion skin"periosteal reaction.
Disease/Dx?
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Ewing sarcoma (maligna
round-cell tumor)
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Labs: "Soap bubble" infemur or tibia on x-ray
Disease/Dx?
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Labs: "Spikes" on basememembrane, "dome-likesubepithelial deposits.
Disease/Dx?
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Membranousglomerulonephritis (ma
progress to nephroticsyndrome)
Labs: "Tennis racket"-
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Labs: Tennis racket
shaped cytoplasmicorganelles (EM) in
Langerhans cells.Disease/Dx?
Birbeck granules
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Birbeck granules
(Langerhans cellhistiocytosis or
histiocytosis X:eosinophilic granuloma
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Labs: "Thumb sign" onlateral x-ray. Disease/Dx
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Epiglottitis (Haemophiluinfluenzae)
Labs: "Tram-track"
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Labs: Tram-track
appearance of capillary looof glomerular basement
membranes on lightmicroscopy. Disease/Dx?
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Membranoproliferativeglomerulonephritis
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Labs: "Waxy" casts with very low urine flow.
Disease/Dx?
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Chronic end-stage renadisease
b " i l "
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Labs: "Wire loop"glomerular capillary appearance on light
microscopy. Disease/Dx
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Lupus nephropathy
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Labs: Anti-glomerular basement membrane
antibodies. Disease/Dx
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Goodpasture syndrome(glomerulonephritis and
hemoptysis)
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Labs: Anti-IgG antibodieDisease/Dx?
Rh t id th iti
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Rheumatoid arthritis(systemic inflammation
joint pannus, boutonnie
rdeformity)
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Labs: Anti-topoisomerasantibodies. Disease/Dx
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Diffuse systemicscleroderma
L b A ti
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Labs: Anti-transglutaminase/anti-gliadin/anti-endomysiaantibodies. Disease/Dx
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Celiac disease (diarrheadistention, weight loss)
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Labs: Anticentromereantibodies. Disease/Dx
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Scleroderma (CREST)
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Labs: Antidesmoglein(epithelial) antibodies.
Disease/Dx?
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Pemphigus vulgaris(blistering)
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Labs: Antihistoneantibodies. Disease/Dx
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Drug-induced SLE(hydralazine, INH,
phenytoin, procainamid
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Labs: Antimitochondriaantibodies (AMAs).
Disease/Dx?
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1° biliary cirrhosis (femacholestasis, portal
hypertension)
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Labs: Antineutrophilcytoplasmic antibodies
(ANCAs). Disease/Dx?
Microscopic polyangiitis andCh St d
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Churg-Strauss syndrome(MPO-ANCA/p-ANCA);granulomatosis with
polyangiitis (Wegener; PR3- ANCA/c-ANCA)
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SLE (type IIIhypersensitivity)
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Labs: Antiplateletantibodies. Disease/Dx
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Idiopathicthrombocytopenic purpu
Labs: Azurophilic
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peroxidase, + granularinclusions in granulocyte
and myeloblasts.Disease/Dx?
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Auer rods (AML, especialthe promyelocytic [M3]
type)
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Labs: Bacitracin responsDisease/Dx?
Sensitive: Streptococcu
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Sensitive: Streptococcu
pyogenes (group A);resistant: Streptococcus
agalactiae (group B)
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Labs: Basophilic nuclearemnants in RBCs.
Disease/Dx?
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Howell-Jolly bodies (duesplenectomy or
nonfunctional spleen)
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Labs: Basophilic stipplinof RBCs. Disease/Dx?
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Lead poisoning orsideroblastic anemia
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Labs: Bloody tap on LPDisease/Dx?
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Subarachnoid hemorrha
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Actinomyces israelii
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Labs: Bronchogenic apiclung tumor on imaging
Disease/Dx?
Pancoast tumor (can
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(
compress sympatheticganglion and cause Horn
syndrome)
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Labs: Cardiomegaly witapical atrophy.
Disease/Dx?
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Chagas disease(Trypanosoma cruzi)
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Labs: Cellular crescents Bowman capsule.
Disease/Dx?
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Rapidly progressivecrescentic
glomerulonephritis
Labs: Circular grouping
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g p g
dark tumor cellssurrounding pale.
Disease/Dx?
Homer-Wright rosettes
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(neuroblastoma,medulloblastoma,
neurofibrilsretinoblastoma)
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Labs: Colonies of mucoiPseudomonas in lungs.
Disease/Dx?
Cystic fibrosis (autosom
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recessive mutation in CFTgene --> fat-soluble
vitamin deficiency andmucous plugs)
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Labs: Decreased AFP inamniotic fluid/materna
serum. Disease/Dx?
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Down syndrome or othechromosomal abnormali
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Labs: Degeneration of dorsal column nerves.
Disease/Dx?
Tabes dorsalis (3° syphili
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subacute combineddegeneration (dorsal
columns and lateralcorticospinal tracts affecte
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Labs: Depigmentation oneurons in substantia
nigra. Disease/Dx?
Parkinson disease (basa
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ganglia disorder: rigidityresting tremor,
bradykinesia)
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Labs: Desquamatedepithelium casts in sputu
Disease/Dx?
Curschmann spirals
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(bronchial asthma; canresult in whorled mucou
plugs)
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Labs: Disarrayed granulocells in eosinophilic fluid
Disease/Dx?
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Call-Exner bodies(granulosa-theca cell tum
of the ovary)
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Labs: Dysplastic squamocervical cells with nuclea
enlargement. Disease/Dx
Koilocytes (HPV:
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predisposes to cervicalcancer) and
hyperchromasia
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Labs: Enlarged cells witintranuclear inclusion
bodies. Disease/Dx?
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"Owl eye" appearance oCMV
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Labs: Enlarged thyroidcells with ground-glass
nuclei. Disease/Dx?
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"Orphan Annie" eyes nuc(papillary carcinoma of t
thyroid)
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Labs: Eosinophiliccytoplasmic inclusion in
liver cell. Disease/Dx?
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Mallory body (alcoholicliver disease)
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Labs: Eosinophiliccytoplasmic inclusion in
nerve cell. Disease/Dx?
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Lewy body (Parkinsondisease)
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Labs: Eosinophilic globuin liver. Disease/Dx?
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Councilman body (toxic viral hepatitis, often yello
fever)
Labs: Eosinophilic
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inclusion bodies incytoplasm of hippocamp
and cerebellar nerve cellDisease/Dx?
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Negri bodies of rabies
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Labs: Extracellular amylodeposition in gray matter
brain. Disease/Dx?
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Senile plaques (Alzheimdisease)
Labs: Giant B cells with
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bilobed nuclei withprominent inclusions
("owl's eye"). Disease/Dx
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Reed-Sternberg cells(Hodgkin lymphoma)
Labs: Glomerulus-like
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structure surrounding vessel in germ cells.
Disease/Dx?
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Schiller-Duval bodies (yosac tumor)
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Labs: hCG elevated.Disease/Dx?
Choriocarcinoma,
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hydatidiform mole (occu with and without embry
and multiple pregnancy
Labs: Heart nodules
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(granulomatous).
Disease/Dx?
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Aschoff bodies (rheumatfever)
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Labs: Heterophileantibodies. Disease/Dx
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Infectious mononucleos(EBV)
Labs: Hexagonal, double
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pointed, needle-likecrystals in bronchial
secretions. Disease/Dx?
Bronchial asthma
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(Charcot-Leyden crystal
eosinophilic granules)
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Labs: High level of D-dimers. Disease/Dx?
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DVT, PE, DIC
Labs: Hilar lymphadenopath
i h l l l i
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peripheral granulomatous lesiin middle or lower lung lobe
(can calcify). Disease/Dx?
h l (
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Ghon complex (1° TB:Mycobacterium bacilli)
Labs: Hypercoagulabilit
(l di i i
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(leading to migrating DVand vasculitis).
Disease/Dx?
Trousseau syndromed f
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(adenocarcinoma of
pancreas or lung)
L b H d
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Labs: Hypersegmentedneutrophils. Disease/Dx
Megaloblastic anemia (Bdeficiency: neurologic
f l
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symptoms; folate
deficiency: no neurologisymptoms)
Labs: Hypertension,h k l i b li
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hypokalemia, metabolic
alkalosis. Disease/Dx?
C d
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Conn syndrome
Labs: Hypochromic,i i i
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microcytic anemia.Disease/Dx?
Iron deficiency anemia
l d i i th l
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lead poisoning, thalassem(fetal hemoglobin
sometimes present)
Labs: Increased AFP ini ti fl id/ t
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amniotic fluid/maternaserum. Disease/Dx?
Dating error, anencephali bifid ( l t b
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spina bifida (neural tubdefects)
L b I d i i
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Labs: Increased uric acilevels. Disease/Dx?
Gout, Lesch-Nyhan
d t l i
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syndrome, tumor lysissyndrome, loop and
thiazide diuretics
Labs: Intranucleari hili d l t lik
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eosinophilic droplet-lik bodies. Disease/Dx?
C d t A b di (H
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Cowdry type A bodies (Hor CMV)
Labs: Iron-containingd l i l l t
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nodules in alveolar septuDisease/Dx?
Ferruginous bodies(asbestosis: inc chance o
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(asbestosis: inc chance omesothelioma)
Labs: Keratin pearls on
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Labs: Keratin pearls on skin biopsy. Disease/Dx
Squamous cell carcinom
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Squamous cell carcinom
Labs: Large lysosomal
vesicles in phagocytes
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vesicles in phagocytes,immunodeficiency.
Disease/Dx?
Che diak-Higashi diseas(congenital failure of
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(congenital failure of phagolysosome formatio
Labs: Linear appearance
IgG deposition on
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IgG deposition onglomerular basement.
Disease/Dx?
Goodpasture syndrome
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Goodpasture syndromemembrane
Labs: Low serumceruloplasmin
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ceruloplasmin.Disease/Dx?
Wilson disease(hepatolenticular
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(hepatolenticulardegeneration)
Labs: Lytic ("holepunched") bone lesions o
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punched ) bone lesions ox-ray. Disease/Dx?
Multiple myeloma
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Multiple myeloma
Labs: Mammary gland("blue domed") cyst
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( blue domed ) cyst.Disease/Dx?
Fibrocystic change of th
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Fibrocystic change of th breast
Labs: Monoclonal antibo
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Labs: Monoclonal antibospike. Disease/Dx?
* Multiple myeloma (usually IgG or IgA* Monoclonal gammopathy of undetermined significance (MGUSconsequence of aging)
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consequence of aging)* Waldenstro m (M protein = IgM)
macroglobulinemia or*Primary amyloidosis
Labs: Mucin-filled cell wi
peripheral nucleus
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peripheral nucleus.Disease/Dx?
"Signet ring" (gastric
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Signet ring (gastriccarcinoma)
Labs: Narrowing of bow
lumen on barium x-ray
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lumen on barium x rayDisease/Dx?
"String sign" (Crohndi )
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String sign (Crohndisease)
Labs: Necrotizing vasculi
(lungs) and necrotizingl l h i i
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(lungs) and necrotizingglomerulonephritis.
Disease/Dx?
Granulomatosis withpolyangiitis (Wegener; PR3
ANCA/c-ANCA) andG d d (
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ANCA/c ANCA) andGoodpasture syndrome (ant
basement membraneantibodies)
Labs: Needle-shaped,
negatively birefringent
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negatively birefringentcrystals. Disease/Dx?
Gout (monosodium uratl )
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Gout (monosodium uratcrystals)
Labs: Nodular hyaline
deposits in glomeruli
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deposits in glomeruli.Disease/Dx?
Kimmelstiel-Wilson
nodules (diabetic
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nodules (diabeticnephropathy)
Labs: Novobiocin responDi /D ?
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Labs: Novobiocin responDisease/Dx?
Sensitive: Staphylococcu
epidermidis; resistant:St h l
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epidermidis; resistant:Staphylococcus
saprophyticus
Labs: Optochin responsDi /D ?
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Labs: Optochin responsDisease/Dx?
Sensitive: Streptococcu
pneumoniae; resistant:
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pneumoniae; resistant: viridans streptococci
Labs: Periosteum raised
from bone, creatingtriang lar area
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from bone, creatingtriangular area.
Disease/Dx?
Codman triangle on x-ra
(osteosarcoma, Ewingsarcoma pyogenic
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(osteosarcoma, Ewingsarcoma, pyogenic
osteomyelitis)
Labs: Podocyte fusion o
"effacement" on electro
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effacement on electromicroscopy. Disease/Dx
Minimal change disease
(child with nephrotic
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(child with nephroticsyndrome)
Labs: Polished, "ivory-lik
appearance of bone atcartilage erosion
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pp bcartilage erosion.
Disease/Dx?
Eburnation (osteoarthritresulting in bony sclerosi
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(resulting in bony sclerosi
Labs: Protein aggregates
neurons fromhyperphosphorylation o
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hyperphosphorylation o
tau protein. Disease/Dx
Neurofibrillary tangles
(Alzheimer disease) and
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( )Pick bodies (Pick disease
Labs: Psammoma bodieDisease/Dx?
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Disease/Dx?
Meningiomas, papillarythyroid carcinoma,
mesothelioma, papillary
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, p p yserous carcinoma of the
endometrium and ovary
Labs: Pseudopalisading
tumor cells on brain
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biopsy. Disease/Dx?
Glioblastoma multiform
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Labs: RBC casts in urineDisease/Dx?
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Disease/Dx?
Acute glomerulonephrit
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g p
Labs: Rectangular, crysta
like, cytoplasmic inclusioin Leydig cells
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, y pin Leydig cells.
Disease/Dx?
Reinke crystals (Leydig ctumor)
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y y gtumor)
Labs: Renal epithelial casin urine Disease/Dx?
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pin urine. Disease/Dx?
Acute toxic/viral renalinjury
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injury
Labs: Rhomboid crystal
positively birefringent.
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Disease/Dx?
Pseudogout (calcium
pyrophosphate dihydratl )
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crystals)
Labs: Rib notching.Disease/Dx?
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Disease/Dx?
Coarctation of the aorta
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Labs: Ring-enhancing
brain lesion in AIDS.Di /D ?
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Disease/Dx?
Toxoplasma gondii, CNlymphoma
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y p o a
Labs: Sheets of medium-sized lymphoid cells with
scattered pale, tingible bodl d h (" t
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laden macrophages ("starry
sky" histology). Disease/Dx
Burkitt lymphoma (t[8:1c-myc activation,
associated with EBV;"bl k k " d f
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"black sky" made up of
malignant cells)
Labs: Silver-staining
spherical aggregation of tproteins in neurons.
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p
Disease/Dx?
Pick bodies (Pick disease
progressive dementia,h i lit )
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changes in personality)
Labs: Stacks of RBCs.Disease/Dx?
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/
Rouleaux formation (higESR, multiple myeloma
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, p y
Labs: Stippled vaginal
epithelial cells.Di /D ?
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Disease/Dx?
"Clue cells" (Gardnerell vaginalis)
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g
Labs: Thrombi made of
white/red layers.Disease/Dx?
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Disease/Dx?
Lines of Zahn (arterial
thrombus, layers of platelets/RBCs)
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platelets/RBCs)
Labs: Thyroid-like
appearance of kidney.Disease/Dx?
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Disease/Dx?
Chronic bacterialpyelonephritis
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Labs: Triglyceride
accumulation in liver cevacuoles Disease/Dx?
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vacuoles. Disease/Dx?
Fatty liver disease
(alcoholic or metabolicsyndrome)
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syndrome)
Labs: WBC casts in urinDisease/Dx?
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Acute pyelonephritis
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Labs: WBCs that look "smudged". Disease/Dx
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CLL (almost always B ce
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Labs: Yellowish CSF.Disease/Dx?
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Xanthochromia (e.g., du
to subarachnoidhemorrhage)
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hemorrhage)
Large rash with bull's-eyappearance. Disease/Dx
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Erythema chronicummigrans from Ixodes tic
bite (Lyme disease:
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Borrelia)
Late cyanotic shunt(uncorrected left to righ becomes right to left).
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Association?
Eisenmenger syndrome
(caused by ASD, VSD, PDresults in pulmonary
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hypertension/polycythem
Liver disease. Association
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Alcoholic cirrhosis
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Lucid interval after
traumatic brain injury.Disease/Dx?
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Disease/Dx?
Epidural hematoma
(middle meningeal arterrupture)
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rupture)
Lysosomal storage diseas Association?
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Gaucher disease
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Male cancer. Association
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Prostatic carcinoma
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Male child, recurrent
infections, no mature Bcells. Disease/Dx?
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/
Bruton disease (X-linkeagammaglobulinemia)
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Malignancy (kids). Association?
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ALL, medulloblastoma(cerebellum)
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Malignancy associated wi
noninfectious fever. Association?
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Hodgkin lymphoma
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Metastases to bone. Association?
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Prostate, breast > lung thyroid
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Metastases to brain. Association?
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Lung > breast >
genitourinary > melanom> GI
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Metastases to liver. Association?
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Colon >> stomach,pancreas
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Mitochondrial inheritanc Association?
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Disease occurs in bothmales and females,
inherited through femaleonly
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only
Mitral valve stenosis. Association?
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Rheumatic heart diseas
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Mixed (UMN and LMN
motor neuron disease. Association?
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Amyotrophic lateralsclerosis
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Mucosal bleeding and
prolonged bleeding timeDisease/Dx?
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Glanzmannthrombasthenia (defect platelet aggregation due
lack of GpIIb/IIIa)
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lack of GpIIb/IIIa)
Muffled heart sounds,
distended neck veins,hypotension. Disease/Dx
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Beck triad of cardiactamponade
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Multiple colon polyps,osteomas/soft tissue
tumors, impacted/supernumerary teeth.
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Disease/Dx?
Gardner syndrome(subtype of FAP)
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Myocarditis. Association
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Coxsackie B
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Myopathy (infantilehypertrophic
cardiomyopathy), exerciintolerance. Disease/Dx
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intolerance. Disease/Dx
Pompe disease (lysosom
α-1,4-glucosidasedeficiency)
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Neonate with arm paraly
following difficult birthDisease/Dx?
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Erb-Duchenne palsy (superior trunk [C5-C6 brachial plexus injury:
"waiter's tip")
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p )
Nephrotic syndrome(adults). Association?
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Focal segmentalglomerulosclerosis
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Nephrotic syndrome (kid Association?
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Minimal change disease
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Neuron migration failur
Association?
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Kallmann syndrome(hypogonadotropic
hypogonadism andanosmia)
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)
No lactation postpartum
absent menstruation, cointolerance. Disease/Dx
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Sheehan syndrome
(pituitary infarction)
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Nosocomial pneumonia
Association?
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Klebsiella, E. coli,
Pseudomonas aeruginos
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Nystagmus, intentiontremor, scanning speech
bilateral internuclearophthalmoplegia.
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Disease/Dx?
Multiple sclerosis
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Obstruction of male
urinary tract. Association
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BPH
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Opening snap. Associatio
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Mitral stenosis
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Opportunistic infection i
AIDS. Association?
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Pneumocystis jirovecii
pneumonia
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Oscillating slow/fast
breathing. Disease/Dx?
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Cheyne-Stokes respiratio
(central apnea in CHF o inc intracranial pressure
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Osteomyelitis in sickle ce
disease. Association?
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Salmonella
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Osteomyelitis with IV dru
use. Association?
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Pseudomonas, S. aureu
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Osteomyelitis. Associatio
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S. aureus
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Ovarian metastasis from
gastric carcinoma or breacancer. Association?
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Krukenberg tumor (muci
secreting signet-ring cell
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Ovarian tumor (benign
bilateral). Association?
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Serous cystadenoma
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Ovarian tumor
(malignant). Association
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Serous
cystadenocarcinoma
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Painful blue fingers/toe
hemolytic anemia.Disease/Dx?
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Cold agglutinin disease(autoimmune hemolyti
anemia caused by Mycoplasma pneumonia
i f i l i
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infectious mononucleosi
Painful, pale, cold
fingers/toes. Disease/Dx
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Raynaud phenomenon
(vasospasm in extremitie
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Painful, raised red lesion
on pad of fingers/toes.Disease/Dx?
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Osler nodes (infective
endocarditis, immunecomplex deposition)
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Painless erythematous
lesions on palms and soleDisease/Dx?
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Janeway lesions (infectiv
endocarditis, septicemboli/ microabscesses
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Painless jaundice.
Disease/Dx?
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Cancer of the pancreati
head obstructing bile du
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Palpable purpura on buttocks/legs, joint pain
abdominal pain (child)hematuria. Disease/Dx
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Henoch-Scho nlein purpu
(IgA vasculitis affectingskin and kidneys)
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Pancreatic, pituitary,
parathyroid tumors.Disease/Dx?
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MEN 1 (autosomal
dominant)
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Pancreatitis (acute).
Association?
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Gallstones, alcohol
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Pancreatitis (chronic).
Association?
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Alcohol (adults), cystic
fibrosis (kids)
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Patient with
ALL/CLL/AML/CML(ages). Association?
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ALL: child, CLL: adult >
60, AML: adult ~65, CMadult 30-60
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Pelvic inflammatory
disease. Association?
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Chlamydia trachomatis
Neisseria gonorrhoeae
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Periorbital and/or peripheedema, proteinuria,
hypoalbuminemia,hypercholesterolemia.Disease/Dx?
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Nephrotic syndrome
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Philadelphia chromosom
t(9;22) (bcr-abl). Association?
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CML (may sometimes b
associated with ALL/AM
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Pink complexion, dyspne
hyperventilation.Disease/Dx?
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"Pink puffer" (emphysemcentriacinar [smoking]
panacinar [α1-antitrypsideficiency])
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Pituitary tumor.
Association?
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Prolactinoma,
somatotropic "acidophiliadenoma
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Polyuria, renal tubular acidotype II, growth failure,electrolyte imbalances,
hypophosphatemic ricketsDisease/Dx?
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Fanconi syndrome(proximal tubular
reabsorption defect)
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Pruritic, purple, polygonplanar papules and plaqu
(6 P's). Disease/Dx?
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Lichen planus
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Ptosis, miosis, anhidrosi
Disease/Dx?
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Horner syndrome
(sympathetic chain lesio
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Pulmonary hypertension
Association?
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COPD
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Pupil accommodates bu
doesn't react. Disease/Dx
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Argyll Robertson pupil
(neurosyphilis)
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Rapidly progressive leg weakness that ascends
following GI/upperrespiratory infection.
Disease/Dx?
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Disease/Dx?
Guillain-Barre syndrom(acute autoimmune
inflammatory demyelinating
polyneuropathy)
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polyneuropathy)
Rash on palms and sole
Disease/Dx?
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Coxsackie A, 2° syphilisRocky Mountain spotted
fever
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Recurrent colds, unusuaeczema, high serum IgE
Disease/Dx?
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Hyper-IgE syndrome (Josyndrome: neutrophil
chemotaxis abnormality
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Recurrentinflammation/thrombos
of small/medium vessel Association?
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Buerger disease (stronglassociated with tobacco)
extremities
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Red "currant jelly" sputuin alcoholic or diabeticpatients. Disease/Dx?
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Klebsiella pneumoniae
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Red "currant jelly" stool
Disease/Dx?
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Acute mesenteric ischem(adults), intussusceptio
(infants)
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Red urine in the mornin
fragile RBCs. Disease/Dx
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Paroxysmal nocturnal
hemoglobinuria
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Red, itchy, swollen rash
nipple/areola. Disease/D
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Paget disease of the brea(sign of underlying
neoplasm)
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Renal cell carcinoma (bilaterahemangioblastomas,angiomatosis,
pheochromocytoma.Disease/Dx?
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von Hippel-Lindau disea(dominant tumor
suppressor gene mutatio
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Renal tumor. Association
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Renal cell carcinoma:associated with von Hippel-Lindau and cigarette smokinparaneoplastic syndromes(EPO, renin, PTH, ACTH)
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Resting tremor, rigidityakinesia, postural
instability. Disease/Dx?
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Parkinson disease(nigrostriatal dopamine
depletion)
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Retinal hemorrhages wit
pale centers. Disease/Dx
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Roth spots (bacterial
endocarditis)
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Right heart failure due topulmonary cause.
Association?
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Cor pulmonale
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S3 (protodiastolic gallop
Association?
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inc ventricular filling (lefto-right shunt, mitral
regurgitation, LV failur[CHF])
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S4 (presystolic gallop).
Association?
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Stiff/hypertrophic ventric(aortic stenosis, restrictiv
cardiomyopathy)
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Severe jaundice in neona
Disease/Dx?
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Crigler-Najjar syndrom(congenital unconjugate
hyperbilirubinemia)
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Severe RLQ pain withpalpation of LLQ.
Disease/Dx?
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Rovsing sign (acute
appendicitis)
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Severe RLQ pain withrebound tenderness.
Disease/Dx?
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McBurney sign (acute
appendicitis)
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Sexually transmitted
disease. Association?
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Chlamydia (usually
coinfected with gonorrhe
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Short stature, inc incidenof tumors/leukemia,
aplastic anemia.Disease/Dx?
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Fanconi anemia (genetiloss of DNA crosslink
repair; often progresses AML)
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SIADH. Association?
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Small cell carcinoma of t
lung
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Single palmar crease.
Disease/Dx?
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Down syndrome
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Site of diverticula.
Association?
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Sigmoid colon
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Sites of atherosclerosis
Association?
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Abdominal aorta >coronary artery > poplite
artery > carotid artery
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Situs inversus, chronicsinusitis, bronchiectasis
infertility. Disease/Dx?
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Kartagener syndrome(dynein arm defect
affecting cilia)
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Skin hyperpigmentationhypotension, fatigue.
Disease/Dx?
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Addison disease (1°adrenocortical insufficien
causes inc ACTH and inc MSH production)
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Slow, progressive muscl weakness in boys.
Disease/Dx?
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Becker muscular dystrop(X-linked missense
mutation in dystrophinless severe than Duchenn
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Small, irregular red spoton buccal/lingual mucos
with blue-white centerDisease/Dx?
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Koplik spots (measles;
rubeola virus)
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Smooth, flat, moist,painless white lesions o
genitals. Disease/Dx?
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Condylomata lata (2°
syphilis)
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Splinter hemorrhages in
fingernails. Disease/Dx
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Bacterial endocarditis
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Stomach cancer.
Association?
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Adenocarcinoma
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Stomach ulcerations anhigh gastrin levels.
Association?
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Zollinger-Ellison syndrom(gastrinoma of duodenu
or pancreas)
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Streak ovaries, congenital hea
disease, horseshoe kidney,cystic hygroma at birth, short
stature, webbed neck,lymphedema. Disease/Dx?
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Turner syndrome (45,XO
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Sudden swollen/painful btoe joint, tophi.
Disease/Dx?
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Gout/podagra
(hyperuricemia)
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Swollen gums, mucosal bleeding, poor wound
healing, petechiae.Disease/Dx?
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Scurvy (vitamin Cdeficiency: can't
hydroxylate proline/lysinfor collagen synthesis)
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Swollen, hard, painful
finger joints. Disease/Dx
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Osteoarthritis (osteophyton PIP [Bouchard nodes
DIP [Heberden nodes])
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Systolic ejection murmu(crescendo-decrescendo
Disease/Dx?
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Aortic valve stenosis
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t(8;14). Association?
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Burkitt lymphoma (c-my
activation)
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t(9;22). Association?
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Philadelphia chromosom
CML (bcr-abl fusion)
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t(14;18). Association?
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Follicular lymphomas (b
2 activation)
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Temporal arteritis.
Association?
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Risk of ipsilateral blindnedue to thrombosis of
ophthalmic artery;polymyalgia rheumatica
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Testicular tumor.
Association?
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Seminoma (malignant,
radiosensitive)
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Thyroid and parathyroitumors,
pheochromocytoma.Disease/Dx?
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MEN 2A (autosomal
dominant ret mutation
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Thyroid cancer.
Association?
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Papillary carcinoma
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Thyroid tumors,pheochromocytoma,
ganglioneuromatosis.Disease/Dx?
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MEN 2B (autosomal
dominant ret mutation
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Toe extension/fanningupon plantar scrape.
Disease/Dx?
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Babinski sign (UMN lesio
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Tumor in women.
Association?
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Leiomyoma (estrogendependent, not
precancerous)
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Tumor of infancy.
Association?
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Hemangioma (usuallyregresses spontaneously
childhood)
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Tumor of the adrenalmedulla (adults).
Association?
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Pheochromocytoma(usually benign)
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Neuroblastoma(malignant)
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Type of Hodgkin. Association?
Nodular sclerosis (vs
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Nodular sclerosis (vs.
mixed cellularity,lymphocytic
predominance,lymphocytic depletion)
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Type of non-Hodgkin. Association?
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Diffuse large cell
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Unilateral facial droopininvolving forehead.
Disease/Dx?
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Facial nerve (LMN CN Vpalsy)
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Urethritis, conjunctivitiarthritis in a male.
Disease/Dx?
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Reactive arthritisassociated with HLA-B2
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UTI. Association?
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E. coli, Staphylococcussaprophyticus (young
women)
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Vascular birthmark (por wine stain). Disease/Dx
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Hemangioma (benign, bassociated with Sturge-
Weber syndrome)
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Viral encephalitis affectintemporal lobe. Associatio
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HSV-1
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Vitamin deficiency (U.S. Association?
Folate (pregnant women
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(p g
are at high risk; body storonly 3- to 4-month suppl
prevents neural tubedefects)
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Vomiting blood followingastroesophageal
lacerations. Disease/Dx
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Mallory-Weiss syndrom(alcoholic and bulimic
patients)
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Weight loss, diarrhea,arthritis, fever,
adenopathy. Disease/Dx
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Whipple disease(Tropheryma whipplei)