fall 2008 volume 6.2 anesthesia newsvolume 6.2 anesthesia news special anniversary edition. featured...

A publication of UCSF Department of Anesthesia and Perioperative Care

FALL 2008

VOLUME 6.2

Anesthesia News

Special Anniversary Edition

Featured Inside

Timeline of Sentinel

Contributions

Chairs, Chiefs,

and Directors

2 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE

1958

NIH Training Grant

Stuart C. Cullen

First 3-Function

Blood Gas Analyzer

John Severinghaus

Affi liation with East Bay

Children’s Hospital

Stuart C. Cullen

Chair, 1958

Dean, UCSF Medical School, 1966

Ernie Guy

Chief, SFGH, 1959

Department, 1962

Department, 2008

3 Information about 50th Anniversary Events

4 Narrative History of the UCSF Department of Anesthesia

and Perioperative Care

24 Faculty Honors, Awards & Appointments

26 New Faculty

27 Academic Department Chairs from UCSF

28 UCSF Anesthesia Residents, Class of 2011

29 Stuart C. Cullen and William K. Hamilton Awardees

30 Research Faculty Spotlight

32 Peer Reviewed Publications 2007-2008

38 Active Research Grants

Information about 50th Anniversary Events

ANESTHESIA NEWS 3

19641962

Discovery of Central Chemoreceptor

Robert Mitchell

(Loeschke HH, Severinghaus J)

Sol Shnider

Director, Obstetrical Anesthesia, 1962

Morley Singer

1st Director, ICU Moffi tt, 1964

Neri Guadagni

Interim Chair, 1966-67

Invented MAC

Edmond Eger

(Merkel G, Saidman L, Severinghaus J)

Respiratory Control

and High Altitude

John Severinghaus

UCSF Department of Anesthesia

and Perioperative Care celebrates

its 50th Anniversary

Monday, November 10 – Wednesday, November 13:

Open House Events

Please join us in celebrating our 50th Anniversary!

Department of Anesthesia and Perioperative Care staff

and faculty are invited to attend, as well as members of

the broader UCSF community, who have contributed to

the growth and success of our department. Beverages

and light fare will be served. The Department Chair, Dr.

Ronald Miller, will attend and provide opening remarks.

• Monday, November 10, 3 – 5 pm — San Francisco

General Hospital, Conference Room 2A6, Main

Hospital, 2nd Floor

• Wednesday, November 12, 12 – 2 pm — Moffi tt-

Long/Mt. Zion, Millberry Union, Parnassus Campus

• Wednesday, November 12, 3 – 5 pm — Veteran’s

Administration Hospital, Director’s Conference Room

To commemorate its fi rst fi fty years as one of the leading anesthesia departments in the world,

the UCSF Department of Anesthesia will host a week long series of events in San Francisco,

from November 10 – 15, 2008

Saturday, November 15:

Symposium

Mission Bay Conference Center,

Robertson Auditorium, 7 am – 4 pm

CME Credits are available.

The Saturday symposium will be a moderated discus-

sion featuring some of the department’s past and

present leaders, as well as national and international

luminaries. Sessions will highlight many of the ground-

breaking events in research, education, and clinical

care at UCSF – and beyond – and will also look to the

future of anesthesia.

Alumni Gala Reception and Dinner

By invitation only

Palace Hotel, Garden Court and Grand Ballroom, 6 pm

For more information, please go to the website at

http://www.anesthesia.ucsf.edu

50th Anniversary Schedule of Events

Featured Inside


Contributions

Chairs, Chiefs,

and Directors


1964

First Anesthesia Faculty with Joint Appointment in

Department of Pharmacology

Walter Way

Anesthetic Effects in Fetal Lamb Model

Sol Shnider

William K. Hamilton

Chair, 1967

Associate Dean for House Staff Affairs, UCSF, 1973

Joe Lee

1st Director, ICU, SFGH, 1967

On September 4, 1957, Julius Comroe

arrived in Iowa City. The formal reason

was a meeting of the American

Physiologic Society, but Comroe, the

newly appointed director of the planned

Cardiovascular Research Institute (CVRI)

at UCSF, had other things on his mind.

THE

of a

Department

Birth

Stuart C. Cullen, Demo

ANESTHESIA NEWS 5

1969 1972Richard Schlobohm

Director ICU, SFGH, 1970

H. Barrie Fairley

Chief, VAH, 1969

Chief, SFGH, 1973

George Gregory

Director, ICU Moffi tt, 1972

C. Philip Larson

Chief, SFGH, 1972

NIH Center Grant

William K. Hamilton

VAH Affi liation with

Department of Anesthesia

At the time, anesthesia at

UCSF was a small division

in the Department of

Surgery, with few resources or

responsibilities and no research

program. Comroe – who had been

recruited to UCSF as part of an

effort to transform what was widely

regarded as a third-rate medical

school into a truly respected center

of academic medicine – believed

that the emerging discipline of

anesthesia could play an important

role both in enhancing UCSF’s

reputation and helping the CVRI

establish itself as a vital resource

and training vehicle for researchers

across the UCSF campus.

The chair at Iowa, Stuart Cullen,

had built an impressive academic

department. Cullen and Comroe

met that day; by the end of the

meeting, Comroe had asked

Cullen to lead anesthesia at UCSF.

Cullen was intrigued – he relished

the opportunity to improve upon

what he had achieved at Iowa –

but wouldn’t agree to go unless

Comroe could guarantee that

anesthesia would have its own

department, separate from surgery.

Within hours, Comroe convinced

UCSF to meet the demand. When

Cullen called John Severinghaus

(who had just completed an

anesthesia residency with Cullen)

with the news, Severinghaus

immediately agreed to join Cullen

at UCSF. Among their initial

colleagues were existing faculty

members Neri Guadagni and Frank

DeBon; Earnest Guy, who was

brought on as the chief of anesthe-

sia at San Francisco General

Hospital; and a new resident,

Walter “Skip” Way.

It was the birth of a department

that over the next fi fty years would

be at the heart of modern anesthe-

sia’s explosive growth, a depart-

ment that to this day continues to

have an enormous impact on

surgical practice and the manage-

ment of pain. The department’s

research, education, and clinical

care quickly earned and have

maintained reputations that are the

equal or better of any institution in

the world. Its faculty, fellows, and

residents have produced a steady

“This has been the era of modern anesthesia. Until the 1940’s, few physicians were

anesthetists; this was a limited specialty with primitive techniques and a slight

body of knowledge. But then this change occurred. New drugs and techniques were

developed to induce anesthesia, support breathing, relax muscles, and suppress pain.

Technology improved. Suddenly we had ventilators, ECG and anesthetic/respira-

tory gas monitors, the blood gas analyzer. All these made anesthesia safer – and

more expensive. Knowledge that forms the underpinning of any specialty grew. The

information came in a few basic forms: we measured everything affected by anes-

thetics - breathing, kidney function, cardiovascular function.”

– Edmond Eger

stream of remarkable contributions

to medical care and patient safety.

Much of this growth and

achievement is attributable to

stable and visionary leadership.

Since 1958, the department has

known only three chairs – Cullen,

William Hamilton, and Ronald

Miller. Perhaps their most impres-

sive, collective achievement is that

while managing staggering growth

and balancing clinical, research,

and educational demands, they

have never sacrifi ced the depart-

ment’s sense of collegiality and

mutual respect.

Through a series of verbal and

visual snapshots, this edition of the

newsletter attempts to tell the

department’s story.

The Birth of a Department


Contributions

Chairs, Chiefs,

and Directors


1973

Complications and Coagulation Defects

associated with Massive Blood Transfusion

Ronald D. Miller

Anesthetic Uptake and Action 1st Edition

Edmond Eger

Robert Hickey

Chief, VAH, 1973

Gershon Levinson

Director, Obstetrical Anesthesia,

SFGH, 1974

Hillary Don

Director, ICU, Moffi tt;

Director, Respiratory Therapy, 1974

1958-1967T H E Cullen Years

While applying for residency

programs, Ron Miller recalls

attending the Saturday morning

rounds that Cullen had established

upon his arrival. The prime

educational event of the depart-

ment, the rounds were inviolate,

something that had earned the

deep respect of the hospital’s

surgeons. “I sat in the back of the

room and watched residents and

staff openly questioning Cullen’s

opinion…something he obviously

invited,” says Miller. “It helped me

decide that UCSF was where I

wanted to be.”

Stu Cullen’s vision – his spirit

of open exploration, political

savvy, and unwavering commit-

ment to excellence – are the

department’s birthmark.

By all accounts, Stuart Cullen was a visionary The offer to

come to UCSF presented him with an opportunity to not

just repeat, but to surpass what he had built at Iowa.

How could he refuse?

Stuart C. Cullen, MD and Ronald D. Miller, MD

With the help and support

of Julius Comroe and his

Cardiovascular Research

Institute (CVRI), Cullen proved

remarkably adept at securing

funding, attracting talent, and

initiating a research tradition that

would create an enduring list of

historic contributions. Along with

Severinghaus, Guy, and Way,

during his tenure Cullen would also

hire future luminaries that included

Edmond Eger, Ed Munson, Rudolf

deJong, and Sol Shnider. But it

wasn’t merely Cullen’s powerful

infl uence in a specialty poised to

explode that drew the best and

the brightest, it was his personal

charm, his commitment to doing

things right, and his remarkably

open mind.

19781974Robert Willenkin

Director, Resident Education, 1974

Director, Medical Student Clerkship, 1975

Phillipa Newfi eld

Director, Neuroanesthesia, 1977

George Gregory

Director, Pediatric Anesthesia, 1975

William K. Hamilton

Chief of Medical Staff,

UCSF Medical Center, 1978

CPAP for Neonatal Respiratory Distress Syndrome

George Gregory

(Kitterman JH, Phibbs RH, Tooley WH, Hamilton WK)

1st Stuart C. Cullen Visiting Professor

(Robert Dripps) and Annual Dinner

Robert Dripps

Pharmocology of Neuromuscular

Blockade and Reversal

Ronald D. Miller

Stuart C. Cullen, MD

of respiratory physiologists that

Severinghaus convened, a liver

enzyme chemist named Leland

Clark pulled from his pocket a

polarographic O2 electrode with

a polyethylene membrane. Within

days, Severinghaus had begun the

design of a water bath containing

the PCO2 and PO2 electrodes,

with a stirred cuvette for the Clark

electrode. “Clark’s electrode was

the key discovery,” says Severing-

haus. “Fifty years later, every blood

gas analyzer contains a Clark type

electrode.”

Finally, shortly after arriving at

UCSF and with the help of his

friend and colleague Freeman

Bradley, Severinghaus added a pH

electrode to this evolving device,

creating the fi rst three-function

blood gas analyzer. By 1960, he

had built and installed a clinical

blood-gas analyzer in the Moffi t

Hospital OR Suite.

“I initially failed to foresee the

immense clinical potential of blood

gas analysis,” says Severinghaus,

who developed it for his laboratory

pulmonary studies. Yet because of

the way it allows physicians to

safely monitor heavily sedated or

ventilated patients, today no

operating room goes without the

device. His original three-function

analyzer resides in the Smithsonian

as part of an exhibit on the

conquest of pain.

The Master Tinkerer and

the Blood-Gas Analyzer

John Severinghaus was originally a

physicist who had spent the latter

part of World War II designing

radar. It was only after the war that

he turned his attention to medi-

cine, receiving his MD from

Columbia and, in 1952, beginning

an anesthesia residency at the

University of Pennsylvania.

At Penn, a portable paramag-

netic oxygen analyzer fascinated

the man his friend Ted Eger calls

“a master tinkerer.” Using himself

as “human servo” he measured

the uptake of nitrous oxide at the

beginning of an anesthetic,

keeping the oxygen at 20% and

closed system volume constant

using fl ow meters. It was the fi rst

measurement of the uptake of

an anesthetic in a human, a

modest beginning to a crucial

medical advance.

Two years later at a conference,

Severinghaus heard physiological

chemist Richard Stow, describe a

carbon dioxide electrode he had

developed, but could not stabilize.

“A few days later, I built a Stow

type CO2 electrode using a bulb

type Beckman pH electrode, a

silver wire with an AgCl coat, and

a rubber glove membrane. My

contribution was pretty simple,”

says Severinghaus. “Add soda.”

The next step came in early

1956, when at an informal meeting

Discovering and

Exploring the Brain’s

Carbon Dioxide Sensor

Over the years, the Severinghaus

lab became a virtual petri dish for

leading researchers and important

research. Internist Robert Mitchell

joined the lab in 1958 and would

share the space for the next

thirty-two years.



Contributions

Chairs, Chiefs,

and Directors


1979

Optimum PEEP in Acute Pulmonary Failure

H. Barrie Fairley

(Suter P, Eisenberg M)

Michael Roizen

Director, Vascular Anesthesia;

Director, PACU, 1979

George Gregory

1st Director, Pediatric ICU, 1980

H. Barrie Fairley

Associate Dean, SFGH, 1979

SFGH Opens New Facility

Mitchell’s greatest contribution was his discovery,

with Hans Loeschke, of the medullary area that

regulates blood PCO2, keeping spinal fl uid pH

constant. Today, when patients with conditions like

COPD have abnormal CO2 levels, the results are

understood in the context of Mitchell’s chemoreceptors.

That fi nding also “promised to explain a physiologic

mystery,” says Severinghaus. “Why is it that people

acclimatized to high altitude continue to over-breathe

for days after descending?”

To answer that question, Severinghaus, Mitchell and

two colleagues piled in a car and made their way to

UC’s Barcroft Lab in the White Mountain range, east of

the Sierras. They lugged a blood-gas analyzer up there

and volunteered to have their own spinal fl uid tapped.

What they found was the fi rst confi rmation that rapid

changes of cerebrospinal fl uid acid-base explain the

mysteries of acclimatization.

The Big MAC

Ted Eger fi rst became interested in the uptake and

distribution of inhaled anesthetics after hearing a talk

by John Severinghaus when both were still at Iowa. He

spent an hour afterwards arguing with Severinghaus,

telling him he surely was wrong (he wasn’t). Later,

during a stint in the Army, Eger devised a handwritten

iterative equation on how anesthetics move into the

lungs and tissues of the body. Anxious to continue his

work in this area, in 1960 he arrived at UCSF to

become a fellow in the Severinghaus lab.

At the time, various drug companies were compet-

ing to improve upon halothane, which had revolution-

ized anesthesia. One day in Severinghaus’s small,

cramped lab overfl owing with experiments of different

kinds, Severinghaus handed Eger a bottle of some-

thing called halopropane. “He asked me to fi nd out if it

was any good,” says Eger. “And when I asked him how,

exactly, he shrugged and told me I would fi gure it out.”

Stuart C. Cullen, MD

That bottle of halopropane would prove useless as

an anesthetic, but it was the perfect vehicle for Eger to

learn how to compare one anesthetic to another. This

led to his discovery of minimum alveolar concentration

(MAC). In parallel, he enlarged his research on uptake

and distribution. The work on MAC and pharmacoki-

netics, which continues to this day, is unparalleled in its

contribution to understanding inhaled anesthetics’

effect on all aspects of human physiology: breathing,

circulation, cerebral function, neuromuscular control,

and kidney and liver well-being. It is Eger’s work that

enables clinicians to understand how much anesthesia

is required to safely do the job.

19841983Neal Cohen

Director, ICU, Moffi tt;


William K. Hamilton

Associate Dean, Educational Affairs;

Vice Dean, School of Medicine, 1983

Sol Shnider

Interim Chair,

1983-1984

Samuel Hughes


SFGH, 1984

Obstetrical Anesthesia Update

Sol Shnider

Mass Spectrometry for Multi-Patient

End-Tidal Gas Monitoring in the OR

John Severinghaus

(Young W, Ozanne W)

Anesthesia for Obstetrics 1st Edition

Sol Shnider

(Levinson G)

1967-1983T H E Hamilton Years

When Stuart Cullen moved from anesthesia to become Dean

of the UCSF School of Medicine, he recruited the same man

who had replaced him at Iowa to take his place at the UCSF

Department of Anesthesia. William “Bill” Hamilton proved to

be a wise choice.

When he arrived at UCSF,

Hamilton understood

what a powerful jump

start Cullen (and Comroe) had

provided to the department and to

the entire School of Medicine. In

just ten short years, as the

specialty of anesthesia grew, UCSF

had begun a parallel ascent to the

nation’s top tier of anesthesia

programs. Cullen’s support for

research efforts were a major

factor, and under Hamilton’s

leadership the research fi rsts kept

coming and the money kept

fl owing. Hamilton believed that the

next step was to enhance the

department’s clinical work and its

educational offerings.

Over the next 16 years, he

improved operating room cover-

age, negotiated a department

agreement that balanced the

needs of clinicians and researchers

and, with the help of Sol Shnider,

established a very close relation-

ship with the department of

obstetrics. His charm, infl uence in

the fi eld, and startling intelligence

also proved remarkably effective at

attracting top-notch talent and at

placing people on projects and

collaborations that would yield

important advances. Perhaps most

important, at a time when newly

established ICUs were not

William K. Hamilton, MD


Contributions

Chairs, Chiefs,

and Directors

1984Ronald D. Miller

Chair, 1984

Mark Rosen


Jerome Strong


Combined Transcutaneous PCO2

and PO2 Blood-Gas Electrode

John Severinghaus

1st Edition Anesthesia

Ronald D. Miller

Morley Singer, MD

generating professional fees and

other anesthesia departments

were abandoning them, Hamilton

had the foresight to insist that the

department maintain control of

these units at UCSF. Today, most

hospitals have maybe one

board-certifi ed anesthesia-intensiv-

ist in critical care; UCSF has 27.

All of this contributed to the

department playing an increasingly

important role in the overall picture

of the school. Hamilton believes

that the department’s growth

during his tenure made it that

much more important to maintain a

sense of departmental camarade-

rie. The informal get-togethers at

his home were a cherished tradition.

called adoring crowds, who walked

away smiling, but armed as well

with new and important knowledge.

In fact, though his human and

animal studies were fi rst rate,

Shnider’s greatest contribution

may have been as a teacher. He

wrote the seminal text on OB

anesthesia, which began as a

refresher course for residents.

Eventually, the annual OB meeting

Shnider initiated at UCSF would

draw some 400-500 residents and

practicing physicians from all over

the world.

“It fi lled a huge need for lots of

people,” says Rosen. “The thing

about Sol is that beneath all the

showmanship he was very, very

professional; he rehearsed his talks

– even the showy parts – down to

the second and they were always

fl awless.”

Saving Newborns in

Respiratory Distress

During his time at Iowa, Bill

Hamilton had been disturbed by

the newborns he treated who were

in respiratory distress. “I could hear

the tiny alveoli popping and I found

if I kept the bag tight, I could keep

the airway from collapsing on

itself,” says Hamilton. At the time

100 percent oxygen was the

standard gas for treating patients

in respiratory distress and by

maintaining pressure using pure

oxygen, says Hamilton “We found

“We were still small enough to do

that,” says Hamilton. “My wife and

I simply continued what Dr. Cullen

and his wife had begun.”

The Pied Piper

of OB Anesthesia

After training at Columbia with

Virginia Apgar, Sol Shnider arrived

at UCSF in 1966 to begin a

division of OB Anesthesia. A giant

of a personality whose social circle

included the world’s most promi-

nent opera stars – and who the

department relied upon to organize

and enliven its social and profes-

sional events – Shnider used

engaging showmanship to

signifi cantly advance an important

sub-specialty.

“Sol’s contribution really was that

until the early 1950’s, no one paid

attention to the impact of anesthe-

sia on the fetus,” says Mark

Rosen, a Shnider protégé who

today is UCSF’s director of OB

anesthesia. “He made the world

aware of this concern.”

Shnider accomplished this in a

number of ways. Although he

didn’t invent the fetal lamb model

that enabled researchers to gain a

much better handle on how to

monitor both the fetus and the

mother, he was one of the fi rst to

understand its importance. His

lectures, with their smiling sheep

cartoons and show tune accompa-

niments, drew what could only be

ANESTHESIA NEWS 11

19861985Cedric Bainton

Chief, SFGH, 1985

Gerard Ozanne


Judith Donegan


Anesthesia for Fetal Surgery

Mark Rosen

Awareness during Surgery for Major Trauma

Martin Bogetz

(Katz, J)

TEE Introduced into Clinical Anesthesia

Michael Cahalan

(Kremer P, Schiller N)

Michael Cahalan

Director, Cardiac Anesthesia, 1986

dramatic and immediate respons-

es, but the results weren’t main-

tainable for more than a few

hours. It never occurred to us that

oxygen could be the cause.” When

he arrived at UCSF, however, he

found the ideal person to solve

the problem.

At the time, George Gregory

was in his last year of residency,

and Hamilton put him to work on

devising a treatment for hyaline

membrane disease. “He was

willing, probably because George

isn’t happy unless he’s underpaid,

underfed, and overworked,” says

Hamilton. Working in part from

fi ndings by a group in Boston

about oxygen toxicity, Gregory –

whose commitment to pediatric

anesthesia is legendary – con-

fi rmed that oxygen toxicity was real

and soon discovered that if you

increased airway pressure with

George Gregory, MD

30 percent oxygen, you could

keep the airways open without

harming the lungs. The result was

Continuous Positive Airway

Pressure (CPAP), which has saved

the lives of countless children in

respiratory distress.

Gregory would go on to write

the defi nitive text on pediatric

anesthesia and pediatric intensive

care and is today recognized as

among the foremost authorities on

pediatric anesthesia in the world.

Towards the Safe Use of

Neuromuscular Blockade

One day after returning to UCSF

from a tour as a battlefi eld

physician in Vietnam, Ron Miller

observed Ted Eger studying the

effect of isofl urane in human

volunteers. The two men spoke,

and “I started monitoring neuro-

muscular function in those

volunteers. From there the work

on the interaction of volatile

M&M with William K. Hamilton, MD

1985


Contributions

Chairs, Chiefs,

and Directors


1987Martin Bogetz

1st Director, Ambulatory Surgery Center, 1987

Warren McKay

Director, Pain Management Center,1987

Long Hospital Opens

Pediatric Anesthesia 1st Edition

George Gregory

had it); it was the fi rst time that

drug was brought into the US and

it ended up being the dominant

muscle relaxant in the world for

many years,” says Miller.

Through the late ‘70’s and early

‘80’s Miller published numerous

pieces, including some on the

original assays he developed in

collaboration with Neal Castagnoli

at the School of Pharmacy. These

assays enabled physicians to

measure not just the concentra-

tions of muscle relaxants in the

blood, but also their metabolites;

they also helped UCSF become

the world’s analytical leader in the

kinetics of muscle relaxants.

Eventually, Miller was joined in this

work by James Caldwell, who

arrived from Scotland in 1986 to

do a one-year fellowship; he has

remained at UCSF ever since and

has been instrumental in facilitating

the breadth and depth of clinical

research on muscle relaxants.

“The modeling we did here

helped to explain the areas where

you might get into trouble in the

ICU, where the drugs can accumu-

late over days and weeks,” says

Caldwell. The group’s lead article in

the New England Journal of

Medicine, with Miller as principal

author, was in large part respon-

sible for reductions in the inappro-

priate use of these drugs in the

intensive care setting.

anesthetics and muscle relaxants

evolved,” says Miller, who had

returned from Vietnam thinking he

would continue doing seminal

research he’d begun there on

massive blood transfusions.

Over the next thirty years, Miller

and the many talented residents he

would attract played a central role in

understanding the pharmacokinetics

and dynamics of muscle relaxants

and their antagonists. It’s an under-

standing critical to performing safe

anesthesia, especially today when

hospitals are doing procedures on

ever sicker patients.

One of the most powerful drivers

of this work was the recognition

that with the advent of kidney

transplants in the 1970’s, there

was an increase in post-operative

paralysis. This led Miller to work

with a researcher at Columbia

University (Matteo) who had

developed a radio-immunoassay

for curare. With the help of Matteo’s

Columbia lab, Miller conducted

one of the fi rst kinetic studies to

defi ne how curare was eliminated.

Bill Hamilton then encouraged

Miller to attend a meeting in

London where key players who

were synthesizing new and better

muscle relaxants – and a group

from The Netherlands that had

developed a new assay for

measuring pancuronium – would

also be attending. Miller’s subse-

quent one-year sabbatical enabled

him to conduct kinetic studies with

the Holland group, and begin a

long-term collaboration with a

Scottish chemist, David Savage,

who synthesized over half of the

emerging drugs in the ‘70’s and

‘80’s. That year may also have

contributed to Miller’s inadvertent

interlude as an international “drug

smuggler.”

“I recall getting on an airplane

with a plastic bag that contained

vecuronium (without revealing he

William Hamilton, MD

Ron Miller has a question as Claire Weenig, Terry Vitez,

Neri Guadagni and Walter Way listen

ANESTHESIA NEWS 13

1988Marie Csete

Director, Liver Transplantation

Anesthesia,1988

Yung Sohn

Director, Vascular Anesthesia, 1987

Robert Hickey

Director, Clinical Anesthesia, 1988

Cerebral Hypoxia and Brain Metabolism

Lawrence Litt

Changing Practice of Anesthesia,

Annual Department CME Course

SFGH Hosts Level One Trauma and…Steve McQueen

When Dick Barber arrived in San

Francisco in 1967, the anesthesia

faculty at San Francisco General

Hospital (SFGH) “was a small,

congenial group of three: Earnest

P. Guy, Robert Hudson Smith, and

myself,” says Barber. “The eight

operating rooms were without

piped gases or vacuum. Huge

‘G’ cylinders of nitrous oxide and

oxygen were mounted on the

backside of the anesthesia

machines.”

It was a busy time. SFGH was

the only level one trauma center

for the city, so anesthesia and all

surgical specialties were in house

24 hours a day, seven days a

week, 365 days a year. “We were

all so busy with too many patients

for too few faculty, residents and

outdated equipment to appreciate

the steady increases in staffi ng,

equipment, and general support

from the city which culminated in

the mid ‘70’s with the opening of

the superbly equipped, brand new

multi-million dollar hospital we so

badly needed,” says Barber. The

new hospital enabled Barber and

his colleagues to continue their

critically important work for a

mostly underserved population.

One interesting note was that

Guy, who was chief at SFGH

during much of this time, had such

respect for his residents that he

often consulted with them about

the in-progress building plans. Ron

Miller recalls that it was during one

such consultation that residents

suggested the elevators be made

bigger so as to make it easier to

William Hamilton, MD


Contributions

Chairs, Chiefs,

and Directors


1988Jeoff Benson

Director, Acute Pain Service, 1989

Mark Rosen


NIH-Sponsored Study of Perioperative Ischemia

Dennis Mangano

(London M, Leung J)

Oak Knoll Naval

Anesthesia Residents join UCSF

Ernie Guy takes apart a Bird Mark 7 to teach Terry Vitez

and Mike Baker its function

transport patients from fl oor to

fl oor. The change was made – and

has been duly appreciated by

clinical staff ever since. “When you

look at the wide elevators at San

Francisco General, just remember

why they were built so wide: Dr.

Guy and the residents in the late

‘60s.” says Miller.

There were many lives saved

and many rewards in Barber’s

12-year stay at SFGH (“the very

best of my professional life,” he

says), but one reward was quite

unexpected. In 1969, the ICU head

nurse called Barber up to Ward 34

where a fi lm team was doing a

“Code Blue scene” for the Steve

McQueen movie, Bullitt. At fi rst

dismissive of leaving his clinical

duties for show business, Barber

eventually relented. He spent the

next few days working with the

Hollywood stars, speaking a few

lines, and joining the Screen Actors

Guild. “It was a good movie

despite my total lack of acting

talent,” says Barber. “I didn’t quit

my day job.”

On to the VA

Barrie Fairley represents one of

the most important recruiting

coups during the Hamilton era.

Originally from the U.K., Fairley

was a true critical care pioneer;

in the 1950s and 1960s, he had

instituted Canada’s fi rst interdisci-

plinary respiratory failure units,

the precursor to today’s critical

care units.

His meeting with Hamilton

happened quite by chance. The

two men shared a research and

clinical interest in respiratory

inadequacy. At a New England

meeting where Hamilton was

scheduled to speak, Fairley

appeared as an unscheduled

replacement speaker. Hamilton

wasted no time in recruiting him.

Fairley arrived at UCSF in early

1969, but had yet to obtain a

California license. Knowing that

Fairley could practice on federal

territory and that UCSF would be

taking over the anesthesia service

at the San Francisco Veteran’s

Administration Hospital, Hamilton

made Fairley that facility’s fi rst

UCSF chief.

The department’s infl uence at

the VA grew quickly under Fairley:

it took over intensive care, and for

the fi rst time placed residents there

who quickly established them-

selves as the in-house on-call

physicians. Fairley also set the

foundations for a VA research

program in anesthesia. Later, after

a year at the Moffi t Hospital, he

would become chief at San

Francisco General for twelve years

and was appointed Associate

Dean at SFGH before assuming

the chair at Stanford University

in 1985.

ANESTHESIA NEWS 15

1989Brian Cason

Chief, VAH, 1989

Lydia Cassorla

Director, Preoperative (Prepare) Clinic, 1989

William Shapiro


Ambulatory Surgery Center opens

Anesthesia Research Laboratories (4th Fl) underwritten by

Anaquest, Organon, Anesthesia Research Foundation and

Anesthesia/Pharmacology Research Foundation

1983-presentT H E Miller Years

After a 10 month international search, Ron Miller took over from

Bill Hamilton (and interim chair Sol Shnider) in 1984 with an

enormous sense of responsibility to make sure the department

stayed at the forefront of the profession. To do so in a modern

era fi lled with increasing regulation and intense competition,

Miller implemented a broad and strategic approach. The

success of that approach speaks for itself, as the UCSF

Department of Anesthesia and Perioperative Care has become

one of the largest and most prestigious in the world.

Early on Miller called for an

outside evaluation of the

research program to ensure

UCSF would stay ahead of the

curve. He aligned the department

with the hospital’s goals, and built

on the strong and respectful

working relationship with surgery

that Hamilton established. Miller

also oversaw a complete revamp-

ing of the department’s fi nances,

developing rigorous systems for

professional fee billing that are still

in place today.

In addition, he has been

tirelessly responsive to external

change. As more anesthesia

sub-specialties have emerged, in

Department, 1980s



Contributions

Chairs, Chiefs,

and Directors


1990Jeffrey Katz

Chief, Mount Zion, 1990

Ken Drasner


Mark Rosen

Director, Residency Program, 1991

Pharmacokinetic and Pharmacodynamic

Research on Intravenous Anesthetics

Dennis Fisher

(Stanski D)

LMA First Used at UCSF

Martin Bogetz

Welcome Residents, 1992

to attract the most, the best, and

the brightest. This included what

was really the fi rst wave of

prominent woman anesthesiolo-

gists, many of whom remain

leaders in their fi eld such as

Pamela Palmer (leading interna-

tional authority in Pain Manage-

ment), Kathryn Rouine-Rapp

(Director of the UCSF Prepare

Clinic), Isobel Russell (Director of

Adult and Pediatric Cardiac

Surgery), Jeanine Wiener-Kronish

(Chairperson of Anesthesia at

Massachusetts General Hospital),

and Sue Carlisle (Associate Dean

of San Francisco General Hospital).

A Fundamentally Better

Way to Monitor Patients

One day in the early 1990’s, in

the Moffi t OR suite, Ron Miller

rushed down the hall and said to

his colleague Michael Cahalan:

“We’re losing this patient; come

take a look.”

When they arrived, Miller

showed Cahalan a septic woman

whose heart rate was 150 beats

per minute and systolic arterial

blood pressure was 50 mmHg.

Miller explained that they had

already given the woman appropri-

ate amounts of blood and still did

not know whether the problem

was hypo- or hypervolemia.

Cahalan, an expert in transesopha-

geal echocardiography (TEE), put a

scope down the woman’s throat,

revealing a nearly empty heart.

After they administered the

appropriate fl uids intravenously,

arterial blood pressure increased

and the heart slowed. The

procedure, known as rescue echo,

is rapidly becoming the standard

for life-threatening hypotension. It

also was the culmination of a

clinical research path that Cahalan

had begun a decade or so before.

In 1981, Cahalan was an

assistant professor working in the

Eger lab when Bill Hamilton asked

him to meet with a new cardiology

the tradition of his predecessors

Miller has continued to recruit the

best faculty and fellows in the

world to establish those sub-speci-

alities at UCSF. As changes in

health care fi nancing and delivery

fostered changes in hospital stays,

Miller oversaw the establishment of

adult and pediatric pre-operative

clinics, under the department’s

watchful eye.

Finally, even when there were

brief downturns in the number of

applicants for anesthesia residen-

cies nationwide, UCSF continued

William Shapiro, MD and Jeffrey Katz, MD

ANESTHESIA NEWS 17

1991 1993Charles Cauldwell


Scott Kelley


Anesthesia, 1992

Richard Weiskopf

Director, Spine Anesthesia, 1992

Robert Allen

Director, Pain Management Center, 1993

Mount Zion Affi liation with UCSF

Perioperative Thermoregulation

Daniel Sessler

fellow named Peter Kramer. Under

the tutelage of Nelson Schiller and

in collaboration with an outside

engineer, Cahalan and Kramer

began working with mini-ultra-

sound transducers mounted on a

gastroscope in an effort to obtain

improved pictures of the heart.

Within months, three groups

around the world received

permission to begin testing the

devices – now with two-dimen-

sional transducers – on human

subjects. Cahalan, Kramer, Schiller,

and Mike Roizen received their fi rst

2-D device in late 1981, while

working in Moffi t’s OR-10.

“We slipped the scope down

and suddenly, in real time, saw a

moving image of all four chambers

of the heart,” says Cahalan. “My

jaw hit the ground and I knew right

away this was a fundamentally

better way to monitor patients.”

Over the next couple of years,

UCSF fellows demonstrated how

TEE provided a much more

accurate measure of ventricular

fi lling than traditional measures of

ischemia. Meanwhile, the purchase

of a 19’’ black and white monitor

for the OR proved to be a critical

“epiphany for the cardio and

vascular surgeons, who saw that

this could answer important

questions about clinical care,” says

Cahalan. Their support proved

crucial, as initially TEE was

considered dangerous and the

papers about it were widely

rejected. When Cahalan returned to

UCSF in 1986, after a sabbatical in

Europe, it was the surgeons’

support that convinced the hospital

to purchase the fi rst commercial

edition of the device.

Today Cahalan, who is now the

chair at the University of Utah, sits

on a committee about to recom-

mend TEE for monitoring during all

cardiac procedures. Anesthesiolo-

gists and surgeons at UCSF had

understood its importance 25 years

ahead of the curve.

“We slipped the scope

down and suddenly, in

real time, saw a moving

image of all four

chambers of the heart.

My jaw hit the ground

and I knew right away

this was a fundamentally

better way to monitor

patients.”

–Michael Cahalan, MD

Laryngoscope Party for Graduating Residents, 1990


Contributions

Chairs, Chiefs,

and Directors


1993Toni Magorian


Sandy Weitz

Director, Acute Pain Service,

1993

Mark Rosen


1994

Management of Pulmonary

Pseudomonas Infection

Jeanine Wiener-Kronish

Diffi cult Airway Management Workshop

Cedric Bainton

The Importance of Being

Normal (thermic)

When he was a resident at UCLA

in the early 1980s, Daniel Sessler

found himself leafi ng through a

smattering of about thirty, mostly

ignored articles on temperature

regulation during surgery. The

consensus was that perioperative

temperature regulation was well

understood and of little conse-

quence except for postoperative

shivering. Sessler didn’t believe the

system was so simple and began a

series of several hundred studies,

mostly conducted during his fi fteen

years as a faculty member in the

UCSF Department of Anesthesia

Sessler’s team, today known as

the Outcomes Research Consor-

tium, initially focused on tempera-

ture regulation. They showed that

general anesthetics profoundly

impair thermoregulation, but do

not completely obliterate control.

Instead, control re-emerges when

patients became suffi ciently

hypothermic. The team next

addressed heat balance and

showed that hypothermia develops

with a characteristic three-phase

pattern, with each phase having a

different cause.

The third major phase of the

studies evaluated the consequenc-

es of mild perioperative hypo-

thermia. In a series of major

multi-center outcome trials, Sessler

and his team proved that even just

a couple of degrees of hypotherm-

ia — as is typical in unwarmed

surgical patients — triples the risk

of surgical wound infection,

signifi cantly increases blood loss

and transfusion requirement,

prolongs recovery, and lengthens

hospital duration.

“Once we started looking we

realized prevailing wisdom was

wrong and the consequences of

hypothermia were much more

severe than anyone realized,” says

Sessler. “Consequently, it’s now

the standard of care to keep

surgical patients normothermic.”

“Once we started looking we

realized prevailing wisdom was

wrong and the consequences of

hypothermia were much more

severe than anyone realized.

Consequently, it’s now the

standard of care to keep surgical

patients normothermic.”

–Daniel Sessler, MD

Jerome Strong, MD, Yung Sohn, MD, Joan Howley, MD

1994Ron Vale

William K. Hamilton Distinguished Professor, 1994

Arthur Wallace

Director, Preoperative Clinic VAH, 1994

Neal Cohen

President of Medical Staff,

UCSF Medical Center, 1994-96

Letterman Army

Anesthesia Residents join UCSF

Spinal Neurotoxicity of Local Anesthetics

Ken Drasner

Pupillometry and Anesthesia

Merlin Larson

The Studies in

Perioperative Ischemia

That Changed Cardiology

In the 1990’s, a group of research-

ers at the San Francisco Veteran’s

Administration Hospital led by

Dennis Mangano recognized that

anesthesia research could benefi t

from the type of large, multi-center

clinical trials done by cardiologists.

“We began with an epidemiological

study that found old, sick people

did poorly in surgery. We then

searched for risk factors we could

modulate.” says Art Wallace, part

of the original team.

A subsequent study found that

keeping people unconscious post

surgery could reduce risks, but

was expensive and problematic.

“The question then became: how

can we deliver the hemodynamic

stability of an anesthetic without

making people unconscious?”

says Wallace.

In a large, clinical trial, the group

(now dubbed McSPI for Multi-Cen-

tered Study of Perioperative

Ischemia), moved on to test 17

different drugs – brand names and

generics – from beta blockers to

Alpha 2 agonists and anesthetic

agents. In landmark piece of

research they published in the

New England Journal of Medicine,

McSPI found that the generic beta

blocker atenolol was the most

effective at reducing the risk of both

myocardial ischemia and mortality.

Though the work had – and has

– its skeptics, shortly after

implementing their beta blockade

protocols with patients at the VA,

the facility’s score from the National

Surgical Quality Improvement

Project (NSQIP) went from 1.0 to

0.6. Wallace soon found himself

being invited to various hospitals to

talk about or set up beta blockade

programs. Today, more than a

hundred hospitals across the

country have adopted the McSPI

protocols. Perioperative beta

blockade in select patients has

become a level one standard

of care.

“The question then became: how

can we deliver the hemodynamic

stability of an anesthetic without

making people unconscious?”

–Arthur Wallace, MD

Laryngoscope Party for Graduating Residents, 2008


Contributions

Chairs, Chiefs,

and Directors

1995James Caldwell


Perioperative Medical Director, 1999

James Marks

Director, ICU, SFGH, 1996



Neuroprotection from Hypoxia

Philip Bickler

Vecuronium and Prolonged Paralysis in the ICU

Veronica Segredo

(Caldwell J, Matthay M, Miller RD)

of Defense (DOD) was interested

enough in having an antidote on

hand to provide some modest

funding towards discovering a

safer antitoxin. With a push from

one of his colleagues – and

because he was expert in produc-

ing antibodies – Jim Marks began

almost casually searching for a

safer antidote for botulism.

In particular, he began develop-

ing monoclonal antibodies for the

most common BoNTs: types A, B,

and E. It was complicated work,

for the antibodies not only had to

be potent enough to cope with the

extreme toxicity, but they needed

to address multiple subtypes within

each of the A, B, and E types.

Moreover, unlike many diseases,

single antibodies did not signifi -

cantly neutralize BoNTs in vivo. “It’s

impossible to achieve the required

potency unless you use a combi-

nation of antibodies that bind to

the toxins simultaneously in

different places,” says Marks.

Then 9/11 happened. With a

whole new sense of urgency and a

dramatic increase in support from

the DOD, the work in the Marks lab

accelerated.

His team has now produced a

unique combination of monoclonal

Fighting Bioterrorism

Botulinum neurotoxins (BoNTs) are

the most poisonous substance

known to man. Though actual

botulism cases are rare, they are

widely feared as a possible

biological weapon because of

their potency and the long-lasting

paralysis they cause.

In 1993, the only known

treatments were antibodies derived

from exposed hospital workers

(hard to come by) and antitoxins

derived from horses that have a

very high incidence of serious side

effects. At the time, the Department

Lundy Campbell, MD, Joan Howley, MD and Cheng Quah, MD

Ronald D. Miller, MD, and Tin-Na Kan, MD,

at Simulation Center

ANESTHESIA NEWS 21

19991995Maurice Zwass

Director, Pediatric Anesthesia Fellowship, 1997

Charles Cauldwell

Director, Pediatric Anesthesia, 1998

A. Sue Carlise

Chief, SFGH, 1999

VAH Develops Ambulatory Surgery Unit

Arthur Wallace

Discovery of Non-Immobilizer

Donald Koblin

We’re Physicians First

One of the hallmarks of the Depart-

ment of Anesthesia has been its

collective ability to not just advance

the discipline itself – a critically

important pursuit – but to advance

the entire practice of medicine.

Recruiting William Young to UCSF

in 2000 furthered that role.

In the mid 1980’s, Young was at

Columbia University when he

became interested in the hemody-

namics of how the brain functioned

during and after cerebrovascular

surgery. With strong mentorship by

Columbia’s chiefs of neurosurgery

and stroke neurology, Young and

an interdisciplinary team would

study everything from the forma-

tion and regulation

of blood vessel growth to the

epidemiology, natural history,

antibodies for type A, B, and E

BoNTs. Each type-specifi c

antibody combination binds toxin

simultaneously in three places and

engages in a novel clearance

mechanism that completely

removes the BoNT in one circula-

tory path. The antibodies can be

used for treating acute botulism or

as a vaccine providing protective

levels for between six and twelve

months. The group’s fi ndings on

combining antibodies to increase

potency could be broadly appli-

cable to a range of pathogens and

toxins. Working with a private

company funded by the NIH,

Marks is now scaling up to help

manufacture an antidote to treat A,

B, and E botulism for clinical trials

beginning in 2009.

treatment outcomes, and genetics

of cerebrovascular disease.

In 2000, attracted by “opportuni-

ties to broaden the breadth and

depth of the science,” Young and

two of his fellows (including current

faculty member Tomoki Hashimo-

to) joined the UCSF Department

of Anesthesia and set up the

Center for Cerebrovascular

Research. His was one of the few

large research groups to be recruit-

ed from outside of UCSF. The

center focuses on hemorrhagic

diseases of the brain, especially

intracranial aneurysms and brain

arteriovenous malformations

(AVMs). There are a wide range of

specialities associated with the

center, and eight of the ten core


Walter Way's House, September 1984


Contributions

Chairs, Chiefs,

and Directors


1999Pamela Palmer


Neal Cohen

Vice Dean, UCSF, 2000

John Feiner


Anesthesia, 2000

Outcomes Research: Aging and Postoperative

Delerium and Cognitive Decline

Jacqueline Leung

NIH Training Grant

Lawrence Litt

tive. What each of us do - this

defi nes anesthesiology. Ultimately,

the current status of our specialty

should be an effect – not a cause

– of the questions we ask. And our

reach should exceed our grasp.” ■

who won’t? And, second, as we

learn more about the molecular

mechanisms we can develop

more effective therapies…I think

we’re well on our way to develop-

ing pharmacological or gene

therapies that can stabilize the

blood vessels to decrease the

risk of spontaneous rupture.”

“Anesthesiologists are physi-

cians fi rst,” continues Young.

“Solving some of the critical

questions and problems in

medicine involves tackling

disease causes and cures; such

work requires interdisciplinary

study, to which anesthesiologists,

as perioperative physicians, bring

a unique and important perspec-

members are faculty in the

Department of Anesthesia.

Among its accomplishments,

the center was the fi rst to

associate human genetic

variation with non-inherited

AVMs and to establish a link

between common infl ammatory

processes and disease

progression, including hemor-

rhage. “There are two main

clinical implications for our

fi ndings,” says Young. “First,

we will be able to develop

biomarkers that can help with

prognostication and risk

stratifi cation – to rationally

answer the questions: Who will

benefi t from intervention and

“Ultimately, the current status

of our specialty should be an

effect – not a cause – of the

questions we ask. And our

reach should exceed our grasp.”

–William Young, MD

By Ronald D. Miller, MD

Anesthesia Resident Match Party 2005

ANESTHESIA NEWS 23

2000Jeffrey Katz


Renee Navarro

Perioperative Director, SFGH, 2000

Dorre Nicholau


Linda Liu

Director, Critical Care Fellowship, 2000

Beta Blockade to Reduce Perioperative Mortality

Dennis Mangano

(Wallace A)

John Severinghaus Anesthesia Laboratory Opened

Radiometer

An Illustrious Past

Prepares the Department

for a Challenging Future

“Today, there is an increasing focus on clinical,

translational, and basic science research in the

total perioperative period, including preoperative

evaluation, intraoperative anesthesia, and

critical care and pain medicine.”

– Ronald D. Miller. MD

As this history makes clear, for fi fty

years UCSF has been a national

and international leader in academ-

ic anesthesia. We are positioned

well to assume an even more

prominent role in the years ahead

as academic medicine becomes

more sophisticated and more

central to the delivery of safe, high

quality care.

Obviously, the gifted individuals

who have staffed and led this

department have been the central

factor in our success. Yet it’s also

important to remember that we

have not accomplished all of this

on our own. We have always

depended upon the rest of the

UCSF community – the wealth of

talented people across this

campus, from brilliant basic

scientists to the fi nest clinicians in

the world. Whether it was the

CVRI, the Center for Cerebrovas-

cular Research, or any of the other

fi ne centers and initiatives at UCSF,

anesthesia’s ability to work closely

with other specialties and make

our unique contribution has been

critically important. In the years

ahead, we must expand this role.

To do so will be essential not just

for our own success, but also the

success of this entire campus.

Consider such initiatives as the

new medical center at Mission

Bay; a new orthopaedic institute

opening in 2009; and the 2009

opening of a new stem cell

research building at the UCSF

Parnassus campus, with construc-

tion beginning in late 2008. All of

these developments offer opportu-

nities for groundbreaking collab-

orative work, from bench research

through clinical innovation. We

must seize these opportunities.

We have been successful for half

a century through a combination of

outstanding faculty, the power of

the UCSF campus, and stable and

visionary leadership. In addition to

the examples set by Stu Cullen

and Bill Hamilton, I distinctly recall

the way Rudy Schmidt – who was

dean of the medical school when I

became chair – constantly pushed

me to make us a better depart-

ment. I can’t say I liked it at the

time, but in retrospect it was an

enormously helpful approach. In

that spirit, I challenge those of you

who will lead over the next fi fty

years to engage fully with this cam-

pus, to exert our leadership, and to

ensure that the tradition highlighted

herein will continue – and grow. ■

Faculty Awards, Honors & Appointments


Contributions

Chairs, Chiefs,

and Directors


2000Isobel Russell

Director, Cardiac Anesthesia, 2000

Thomas Shaughnessy

Director, Respiratory Therapy,

2000

Dan Swangard

Director, Preoperative (Prepare) Clinic,

2000

Incentive-Productivity-Based

Compensation System Developed

Ronald D. Miller

John Severinghaus Research Fellowship

underwritten by Radiometer

Institute of Medicine Elected Members

The Institute of Medicine of the National Academies

was chartered in 1970 to provide the nation with

science-based advice on matters of biomedical

science, medicine and health. The Institute’s members,

elected on the basis of their professional achievement

and commitment to service, serve without compensa-

tion in the conduct of studies and other activities on

matters of signifi cance to health. Election to active

membership is both an honor and a commitment to

serve in Institute affairs.

Ronald D. Miller, MD 1998

Jeanine Wiener-Kronish, MD 2002

James Marks, MD, PhD 2006

UCSF Haile T. Debas

Academy of Medical Educators

The Haile T. Debas Academy of Medical Educators is

dedicated to creating an environment that enhances

the status of teachers of medical students at UCSF,

promotes and rewards teaching excellence, fosters

curricular innovation, and encourages scholarship in

medical education. Members of The Haile T. Debas

Academy of Medical Educators actively participate in

the work the Academy performs in pursuit of its goal of

promoting educational excellence in the UCSF

community. Because of the rigor of the selection

process, Academy membership is known to be a sign

of outstanding performance; academy members are

recognized as highly accomplished educators.

Martin Bogetz, MD 2001

Manuel Pardo, MD 2001

Harriet Hopf, MD 2004

Marek Brzezinski 2007

2008 Awards and Honors

Helge Eilers, MD & Mark Schumacher, MD, PhD

Extramural Award:

First Place, 2008 IARS Kosaka Abstract Session, for:

Chu C, Schumacher MA, Bunnett NW, Eilers H.

Inhaled Anesthetics Activate TRPA1Heterologously

Expressed in HEK Cells.

Ronald D. Miller, MD, Chairman

Extramural Honors:

American Society of Anesthesiologists Distinguished

Service Award 2008

American Society of Anesthesiologists Emery A.

Rovenstine Lecturer 2008

John Severinghaus, MD, Professor Emeritus

Extramural Honor:

American Society of Anesthesiologists Eponymous

Lecture, “John W. Severinghaus Lecture on Transla-

tional Science” established 2008

Muhammad Shaikh, MD

Extramural Appointment:

NIH Grant Reviewer, Bioengineering Research

Group, 2007

NIH Grant Reviewer, NIH Fellowship (F-31; F-32)

Biomedical Engineering and Imaging Studies, 2008

ANESTHESIA NEWS 25

2001Pekka Talke


Julin Tang


Mark Grabovac

Director, Spine Anesthesia, 2001

Martin Bogetz


Intraoperative TEE. An Interactive Text and Atlas

Michael Cahalan

Developer, Perioperative Cardiac Risk Reduction

Program at over 100 Medical Centers

Arthur Wallace

American Society

of Anesthesiologists Awards

ASA Award for Excellence in Research

This award recognizes outstanding research that has

had or is likely to have a major impact on the practice

of anesthesia and/or research representing a mature

and sustained contribution to the extension and

advancement of the science of anesthesiology.

John W. Severinhaus, MD 1986

Edmond I. Eger, MD 1989

Daniel I. Sessler, MD 2002

ASA Distinguished Service Award

Annually since 1945, ASA has determined whether to

bestow its most prestigious honor, the Distinguished

Service Award (DSA), on a member for outstanding

clinical, educational or scientifi c achievement or for

contributions to the specialty and/or exemplary service

to ASA. The DSA is presented by the president during

the ASA Annual Meeting at the time of the Emery A.

Rovenstine Memorial Lecture to the individual selected

by the House of Delegates at the previous year’s

Annual Meeting. The award is the ASA’s highest tribute

paid to an anesthesiologist for meritorious service and

achievement. This will be the fi rst year in which the

Rovenstine Lecturer is also bestowed with the

Distinguished Service Award.

Stuart C. Cullen, MD 1964

William K. Hamilton, MD 1986

Edmond I. Eger, MD 1991

Robert K. Stoelting, MD 2003


ASA Annual Emery A. Rovenstine Memorial Lecture

The Rovenstine Lecture is a longstanding high point of

the Annual Meeting and honors Dr. Rovenstine, the

distinguished past chair of the Department of Anesthe-

siology at New York University Medical Center and

Director of Anesthesiology at Bellevue Hospital in New

York City. Dr. Rovenstine was a founding member and

president of the American Board of Anesthesiology,

ASA president in 1943-44 and the 1957 recipient of

the ASA Distinguished Service Award. Because of his

seminal contributions to the specialty, especially as an

administrator and educator, this prestigious lectureship

was established in his name. The ASA president

chooses the lecturer as part of his/her duties, and the

lecture is always one of the highlights of the Annual

Meeting.

William K. Hamilton, MD 1978


ASA John W. Severinghaus Lecture

on Translational Science

In 2008 the ASA approved the naming of its Annual

Meeting Tuesday afternoon translational research

plenary session to henceforth be known as the “John

W. Severinghaus Lecture on Translational Science”,

one of only two eponymous lectures at their annual

meeting. Dr. Severinghaus will give the inaugural

lecture at the 2008 Annual Meeting.

New Anesthesia Faculty

Career Faculty

Jon Matthew Aldrich, MD

Clinical Instructor

Joined Faculty August 1, 2008

Medical School:

Stanford University School of Medicine

Palo Alto, California

Internship:

Surgery

University of California, San Francisco

Residency:

Anesthesiology


Fellowship:

Critical Care Medicine


Marla Ferschl, MD

Clinical Instructor


Medical School:

University of Chicago Pritzker

School of Medicine

Chicago, Illinois

Internship:

Internal Medicine

University of Chicago

Pritzker School of Medicine

Chicago, Illinois

Residency:

Anesthesiology


Judith Hellman, MD

Associate Professor in Residence


Medical School:

Columbia University College of

Physicians and Surgeons

New York, New York

Internship:

Internal Medicine

Oregon Health Sciences University

Portland, Oregon

Residencies:

Internal Medicine

Oregon Health Sciences University

Portland, Oregon

Anesthesiology

Massachusetts General Hospital

Boston, Massachusetts

Fellowship:

Critical Care Medicine



Previous Employment:

Instructor in Anesthesia

Harvard Medical School


Assistant Professor of Anesthesia

Harvard Medical School


Benjamin Houseman, MD, PhD

Assistant Professor in Residence

Joined Faculty January 1, 2008

Advanced Degree:

PhD, Chemistry


Chicago, Illinois

Medical School:


Pritzker School of Medicine

Chicago, Illinois

Internship:

Resurrection Medical Center

Chicago, Illinois

Residency:

Anesthesiology


Visiting Faculty

Kerstin Kolodzie, MD

Visiting Assistant Professor

Joined Faculty December 1, 2007

Medical School:

University of Hamburg

Hamburg, Germany

Jon Matthew Aldrich, MD

Judith Hellman, MD

Benjamin Houseman, MD, PhD

Marla Ferschl, MD


Contributions

Chairs, Chiefs,

and Directors


2001Michael Gropper

Director, ICU, Moffi tt, 2001

Linda Liu


Renee Navarro

Chief of Medical Staff, SFGH, 2001

Cardiac Protection using

Anesthetic Preconditioning

Brian Cason

(Hickey R)

Cloning of Capsaicin Receptor/Its Facilitation

Mark Schumacher

Internship:

Technion-Israel Institute of Technology,

The Ruth and Bruce Rappaport Faculty

of Medicine, Rambam Healthcare

Campus

Haifa, Israel

Residency:

Anesthesiology

University of Hamburg,

University Medical Center

Hamburg-Eppendorf

Hamburg, Germany


Attending Anesthesiologist

University of Hamburg,

University Medical Center

Hamburg-Eppendorf

Hamburg, Germany

Joerg Schaeuble, MD

Visiting Assistant Professor

Joined Faculty December 1, 2007

Medical Schools:

Johann Wolfgang v. Goethe University

Frankfurt, Germany

Albert Ludwigs University of Freiburg

Freiburg, Germany

Internship:

Internal Medicine & Surgery

Hospital Villingen-Schwenningen

Villingen-Schwenningen, Germany

Residencies:

Anesthesiology

Hospital of Waldshut

Waldshut, Germany

Anesthesiology

District Hospital

Tafers, Switzerland

Internal Medicine

District Hospital

Niederbipp, Switzerland

Anesthesiology

Cantonal Hospital of St. Gallen

St. Gallen, Switzerland

Fellowship:

Emergency Medicine




ICU Attending



Attending Anesthesiologist

University Hospital Basel

Basel, Switzerland

Bernard Brandstater American University of Beirut;

Loma Linda University

Michael Cahalan University of Utah

David Cullen St. Elizabeth's Medical Center

and Tufts University

Bruce Cullen University of California, Irvine

Gerald Edelist University of Toronto

John Eisele University of California, Davis

H. Barrie Fairley Stanford University

Greg Kronberg Wilford Hall Medical Center

C. Philip Larson Stanford University

Ronald D. Miller UCSF Anesthesia and

Perioperative Care

Musa Muallem American University of Beruit

Medical Center

Nancy Nussmeier Syracuse University

Richard Palahniuk University of Manitoba;

University of Minnesota

Michael Roizen University of Chicago;

Cleveland Clinic

Stephen Rupp Virginia Mason Medical Center

Lawrence Saidman University of California,

San Diego

David Schwartz University of Illinois

Donald Stanski Stanford University

Wendell Stevens University of Iowa;

University of Oregon

Robert Stoelting Indiana University

Gale Thompson Virginia Mason Medical Center

John Wade University of Manitoba

Jeanine Weiner-Kronish


Paul White University of Texas

Southwestern Medical Center

Academic Department Chairs from UCSF

Kerstin Kolodzie, MD

Joerg Schaeuble, MD

2001Patricia Roth

Director, Anesthesia Workroom, 2001

Julin Tang

Director, ICU, SFGH, 2001

William Young

James P. Livingston Endowed

Chair in Anesthesia, 2001

William Shapiro

Chief, Mount Zion, 2001

Incentive-Productivity-Based Compensation System

Implemented

John Feiner

Improving Wound Healing Outcomes

through Increased Oxygen Delivery

Harriet Hopf

The Birth of a DepartmentUCSF Anesthesia Residents


Contributions

Chairs, Chiefs,

and Directors


2002Daniel Burkhardt


Errol Lobo

Director, Vascular Anesthesia, 2002

Martin London

Chair, UCSF Committee on Library, 2002

Profound Isovolemic Hemodilution

Richard Weiskopf

(Feiner J, Lieberman J, Hopf H, Leung J, Kelly S)

ARDSnet Trial Published

Michael Matthay

(Gropper M)

Class of 2011

Daniel Abelson, MD

Medical School:

University of California, San Francisco,

School of Medicine

Michele Arnold, MD

Medical School:


School of Medicine

Daniel Chiem, MD

Medical School:

University of California, San Diego, School

of Medicine

Joshua Cohen, MD

Medical School:

University of Illinois at Chicago College

of Medicine

Robert Ellis, MD

Medical School:

Virginia Commonwealth University

School of Medicine

Robert Feinglass, MD

Medical School:


School of Medicine

Madina Gerasimov, MD

Medical School:

New York University School of Medicine

Amy Gin, MD

Medical School:

New York Medical College

Roger Hong, MD

Medical School:

Joan & Sanford I. Weill Medical College

of Cornell University

Cristina Inglis-Arkell, MD

Medical School:

University of California, San Diego,

School of Medicine

April Jung, MD

Medical School:

Drexel University College of Medicine

James Kim, MD

Medical School:

Georgetown University School

of Medicine

So Young Kim, MD

Medical School:

Columbia University College

of Physicians and Surgeons

Tse-Sun Ku, MD

Medical School:


School of Medicine

Sara LaFleur, MD

Medical School:

Tufts University School of Medicine

Sarah Langley, MD

Medical School:


Meagan Lansdale, MD

Medical School:


Anuj Malhotra, MD

Medical School:

Duke University School of Medicine

Jemiel Nejim, MD

Medical School:

University of California, Los Angeles,

David Geffen School of Medicine

Swetha Pakala, MD

Medical School:


School of Medicine

Jacob Pletcher, MD

Medical School:

Indiana University School of Medicine

Anna Rabinowitz, MD

Medical School:

University of Pennsylvania School

of Medicine

John Turnbull, MD

Medical School:


School of Medicine

Adrienne Valesano, MD

Medical School:

Georgetown University School of Medicine

Elaine Yang, MD

Medical School:

New York University School of Medicine

Afshin Zadfar, MD

Medical School:

State University of New York at Buffalo,

School of Medicine and Biological Sciences

Stuart C. Cullen and William K. Hamilton Awardees

20042003Manuel Pardo

Sol M. Shnider Endowed Chair for

Anesthesia Education, 2003

Jeffrey Katz

Perioperative Medical Director, 2003

James Brandes

Director, Orthopedic/Regional

Anesthesia, 2004

A. Sue Carlise

Associate Dean,

SFGH, 2004

Center for Cerebrovascular Research

William Young

Anesthesia Simulator SFGH

Manuel Pardo

(Collins A)

Steven D. Jabaly, MD 1980

Glenn Plummer, MD 1981

Manuel Fernandez, MD 1982

Lydia Cassorla, MD 1983

George Lampe, MD 1983

Brian Cason, MD 1984

Edward Eisler, MD 1985

Jeanine Wiener-Kronish, MD 1986

Ginger Fegert, MD 1987

Scott Kelley, MD 1989

Isobel Muhiudeen, MD, PhD 1989

Jaul Riazi, MD 1989

Amanda Sue Carlisle, MD 1990

John R. Feiner, MD 1991

Barry D. Bergouist, MD 1992

Erin P. Foley, MD 1992

Peter S. Nosé, PhD, MD 1992

Gretchen E. Hollingsworth, MD 1993

Oscar Fernandez, MD 1993

Robert F. Hickey, MD 1973

Robert L. Willenkin, MD 1974

Robert H. Smith, MD 1975

Wendell C. Stevens, MD 1976

Marilyn Hulter, MD 1977

A. Roderick Forbes, MB 1978

Dennis T. Mangano, PhD, MD 1979

Neal H. Cohen, MD, MPH 1980

H. Barrie Fairley, MB, BS 1980

Cedric R. Bainton, MD 1981

Sol M. Shnider, MD 1982

Scott Robinson, MD 1983

H. Barrie Fairley, MB, BS 1984

Michael Cahalan, MD 1985

Stephen Rupp, MD 1986

Cedric R. Bainton, MD 1987

Donald Koblin, MD 1988

George A. Gregory, MD 1989

Maurice Zwass, MD 1990

Stuart C. Cullen Award

William K. Hamilton Award

Neil Seeley, MD 1994

Julie Nakao, MD 1994

Manuel Pardo, MD 1995

William Cammarano, MD 1996

Richard Green, MD 1997

Thomas Buchheit, MD 1998

John F. Donovan, MD 1999

Daniel M. Swangard, MD 1999

Dhanesh K. Gupta, MD 2000

Brian W. Hite, MD 2000

James Mac Sams, MD 2001

Donal P. Ryan, MD 2002

Lundy J. Campbell, MD 2003

Grete H. Porteous, MD 2004

Leonard Razzu Allmond, MD 2005

Patrick M. Fujimoto, MD 2006

Jon Matthew Aldrich, MD 2007

Scott Finkelstein, MD 2008

Isobel A. Muhiudeen, MD, PhD 1991


Isobel A. Muhiudeen, MD, PhD 1992

Anil De Silva, MD 1993

Anil De Silva, MD 1994

Robert W. Allen, MD 1995

James E. Caldwell, MB, ChB 1996



Joan E. Howley, MD 1999

Kathryn Rouine-Rapp, MD 2000

Merlin D. Larson, MD 2001

Merlin D. Larson, MD 2002

Daniel M. Swangard, MD 2003

Mark Grabovac, MD 2004


Mark D. Rollins, PhD, MD 2006

Lundy J. Campbell, MD 2007

John Taylor, MD 2008

Research Faculty Spotlight

Helen Kim, PhD

Susan Lynch, PhD


Contributions

Chairs, Chiefs,

and Directors


2004Andrew Gray

Director, Regional Anesthesia, SFGH, 2004

Jeremy Lieberman

Director, Spine Anesthesia,

2004

Renee Navarro

Associate Dean, Academic Affairs, 2004

Monoclonal Antibody for

Treatment of Botulinum Neurotoxins

James Marks

NIH Training Grant


Helen Kim, PhD

Assistant Adjunct Professor

Education and Training:

MPH, Epidemiology, Emory University, Atlanta GA

PhD, Epidemiology, University of Washington, Seattle, WA

Postdoctoral Fellow, Genetic Epidemiology, University of Washington, Seattle, WA

Research Interests:

Genetic epidemiology of cardiovascular and neurological diseases, and in particular stroke

Epidemiology and natural history of brain vascular malformations, including AVM

and aneurysms

Functional outcome after brain injury from intracranial hemorrhage or treatment

Linkage and association studies of complex diseases and intermediate phenotypes

Methods for detecting and adjusting for population stratifi cation,

and evaluating interactions

Susan Lynch, PhD



BS, Industrial Microbiology (minors in Chemistry and Biostatistics), University College,

Dublin, Ireland

PhD, Department of Microbiology, University College, Dublin, Ireland

Postgraduate Education, Department of Microbiology and Immunology, Stanford

University School of Medicine, Stanford, CA

Research Interests:

Polymicrobial pathogenesis of respiratory diseases including, cystic fi brosis, asthma,

ventilator-associated pneumonia, chronic rhinosinusitis and chronic obstructive

pulmonary disease.

Biofi lm formation and virulence gene expression of the respiratory pathogen

Pseudomonas aeruginosa from both Cystic Fibrosis (CF) and ICU patients

Understanding of the response of Pseudomonas aeruginosa in a clinical setting,

improve diagnosis and provide effi cacious strain-specifi c combinatorial therapeutic

options to improve patient outcome.

Uses culture-independent tools recently developed in the fi eld of microbial ecology

together with high-throughput sequencing and statistical analysis to examine the

contribution of microbial community structure and function to pathogen behavior,

host response and clinical outcome.

Development of a rapid, multi-species, culture-independent tool to improve diagnosis

of respiratory infections and profi le antimicrobial resistance in parallel.

Examines therapeutic strategies in vitro and in vivo that target various virulence systems

of Pseudomonas aeruginosa and uses sequential clinical isolates to study how

micro- and macro-evolution affects the physiology of this opportunistic pathogen.

Ludmila Pawlikowska, PhD Hua Su, MD

ANESTHESIA NEWS 31

Jens Krombach

Director, Clinical Anesthesia, SFGH, 2005

Kathryn Rouine-Rapp


James Caldwell


Developer of Endotracheal

Cardiac Output Monitor

Arthur Wallace

Sonography for Nerve Block Localization

Andrew Gray

(Collins A)

2005Gerard Ozanne

Acting Chief, VAH, 2004

Ludmila Pawlikowska, PhD



Ph.D. Biomedical Sciences, UCSF

Postdoctoral training: Liver Center, Cardiovascular Research Institute and Institute

for Human Genetics, UCSF

Research Interests:

Genetic studies of complex disease including brain arteriovenous malformation

and subarachnoid hemorrhage

Genetic studies of human longevity and aging-related phenotypes

Admixture mapping of metabolic syndrome traits and infl ammatory markers

in admixed populations

Molecular genetics of inherited cholestasis

Hua Su, MD



MD, Medicine, 1982, Nanjing Medical University, Nanjing, China

MS, Histology and Embryology, 1985, Xian Medical University,

Xian, China

Postdoctoral Fellow, Reproductive Physiology, 1986,

Beijing Medical University, Beijing, China

Postdoctoral Fellow, Medical Genetics, 1992,

University of California, San Francisco, CA

Research Interests:

Viral vector mediated targeted gene expression

Gene and cell based therapies for ischemic heart disease

Gene and cell based therapies for cerebral vascular diseases

Development of rodent arteriovenous malformation model

Peer Reviewed Publications 2007–2008

Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D.

Monitoring serial change in the lumen and outer wall of vertebrobasilar

aneurysms. AJNR Am J Neuroradiol. Feb;29(2):259-64, 2008.

Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF.

Acute coagulopathy of trauma: hypoperfusion induces systemic

anticoagulation and hyperfi brinolysis. J Trauma. May;64(5):1211-7, 2008.

Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner

JM. Ammonia has anesthetic properties. Anesth Analg. Jun;104(6):1430-3,

2007.

Brosnan RJ, Eger EI 2nd, Laster MJ, Sonner JM. Anesthetic properties of

carbon dioxide in the rat. Anesth Analg. Jul;105(1):103-6, 2007.

Carles M, Dellamonica J, Roux J, Lena D, Levraut J, Pittet JF, Boileau P,

Raucoules-Aime M. Sevofl urane but not propofol increases interstitial

glycolysis metabolites availability during tourniquet-induced ischaemia-

reperfusion. Br J Anaesth. Jan;100(1):29-35, 2008.

Cascio M, Xing Y, Gong D, Popovich J, Eger EI 2nd, Sen S, Peltz G, Sonner

JM. Mouse chromosome 7 harbors a quantitative trait locus for isofl urane

minimum alveolar concentration. Anesth Analg. Aug;105(2):381-5, 2007.

Champion HR, Fingerhut A, Escobar MA, Weiskopf RB. The role of data and

safety monitoring in acute trauma resuscitation research. J Am Coll Surg.

Jan;204(1):73-83, 2007.

Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler

PE, Drew KL. Arctic ground squirrel (Spermophilus parryii) hippocampal

neurons tolerate prolonged oxygen-glucose deprivation and maintain

baseline ERK1/2 and JNK activation despite drastic ATP loss. J Cereb Blood

Flow Metab. Jul;28(7):1307-19, 2008.

Coburn M, Kunitz O, Apfel CC, Hein M, Fries M, Rossaint R. Incidence of

postoperative nausea and emetic episodes after xenon anaesthesia

compared with propofol-based anaesthesia. Br J Anaesth.

Jun;100(6):787-91 2008.

Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early

coagulopathy after traumatic brain injury: the role of hypoperfusion and the

protein C pathway. J Trauma. Dec;63(6):1254-61, 2007.

Cohen NH. Advance directives: know what you want, get what you need.

Mayo Clin Proc. Dec;82(12):1460-2, 2007.

Du R, Keyoung HM, Dowd CF, Young WL, Lawton MT. The effects of

diffuseness and deep perforating artery supply on outcomes after

microsurgical resection of brain arteriovenous malformations. Neurosurgery.

Apr;60(4):638-46, 2007.

Dubowitz G, Peacock AJ. Pulmonary artery pressure in healthy subjects at

4250 m measured by Doppler echocardiography. Wilderness Environ Med.

Winter;18(4):305-11 2007.

Abou-Arab MH, Heier T, Caldwell JE. Dose of alfentanil needed to obtain

optimal intubation conditions during rapid-sequence induction of

anaesthesia with thiopentone and rocuronium. Br J Anaesth.

May;98(5):604-10, 2007.

Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU,

Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL.

Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2

polymorphisms with intracranial hemorrhage after brain arteriovenous

malformation treatment. Neurosurgery. Oct;61(4):731-9; discussion 740,

2007.

Afonin ON, Miller RD. Sugammadex: An analysis and update. ASEAN J.

Anaesthesiology 8:35-40, 2007.

Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson

R, Maze M, Franks NP. Determinants of the anesthetic sensitivity of two-pore

domain acid-sensitive potassium channels: molecular cloning of an

anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol

Chem. Jul 20;282(29):20977-90, 2007.

Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ,

Jankowska K, Eger EI 2nd. Hexafl uorobenzene acts in the spinal cord,

whereas o-difl uorobenzene acts in both brain and spinal cord, to produce

immobility. Anesth Analg. Apr;104(4):822-8, 2007.

Antognini JF, Atherley RJ, Dutton RC, Laster MJ, Eger EI 2nd, Carstens E. The

excitatory and inhibitory effects of nitrous oxide on spinal neuronal

responses to noxious stimulation. Anesth Analg. Apr;104(4):829-35, 2007.

Apfel CC, Kranke P, Piper S, Rüsch D, Kerger H, Steinfath M, Stöcklein K,

Spahn DR, Möllhoff T, Danner K, Biedler A, Hohenhaus M, Zwissler B,

Danzeisen O, Gerber H, Kretz FJ. [Nausea and vomiting in the postoperative

phase. Expert- and evidence-based recommendations for prophylaxis and

therapy] Anaesthesist. Nov;56(11):1170-80, 2007.

Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA. Septate junctions

are required for ommatidial integrity and blood-eye barrier function in

Drosophila. Dev Biol. May 15;317(2):585-99, 2008.

Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU.

Remote renal injury following partial hepatic ischemia/reperfusion injury in

rats. J Gastrointest Surg. Mar;12(3):490-5, 2008.

Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI 2nd, Pearce RA.

Determination of the EC50 amnesic concentration of etomidate and its

diffusion profi le in brain tissue: implications for in vitro studies.

Anesthesiology. Jan;106(1):114-23, 2007.

Berman MF, Young WL. Commentary on: Brain arteriovenous malformation

and its implication in forensic pathology. J Forensic Sci. Sep;52(5):1225,

2007.

Boussel L, Wintermark M, Martin A, Dispensa B, VanTijen R, Leach J, Rayz V,


Contributions

Chairs, Chiefs,

and Directors


2005Atsuko Baba

Director, Pediatric Prepare Clinic,

2006

Philip Bickler

Director, Orthopedic/Regional

Anesthesia, 2006

Manual of Anesthesia Practice

(1st PDA Textbook in Anesthesia)

Manuel Pardo, James Sonner

(Primarily authored by UCSF residents)


First in NIH Funding

David Lee


Edwards KL, Hutter CM, Yin Wan J, Kim H, Monks SA. Genome-wide Linkage

Scan for the Metabolic Syndrome: The GENNID Study. Obesity (Silver Spring).

Jul;16(7):1596-1601, 2008.

Eger EI 2nd, Lemal D, Laster MJ, Liao M, Jankowska K, Raghavanpillai A,

Popov AV, Gan Y, Lou Y. Anesthetic properties of some fl uorinated oxolanes

and oxetanes. Anesth Analg. May;104(5):1090-7, 2007.

Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. The rat vanilloid

receptor splice variant VR.5’sv blocks TRPV1 activation. Neuroreport. Jul

2;18(10):969-73, 2007.

El Solh AA, Akinnusi ME, Wiener-Kronish JP, Lynch SV, Pineda LA, Szarpa K.

Persistent infection with Pseudomonas aeruginosa in ventilator-associated

pneumonia. Am J Respir Crit Care Med. Sep 1;178(5):513-9, 2008.

Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y.

Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res. Jul

11;1219:1-7, 2008.

Fan Y, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young

WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial

progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab.

Jan;28(1):90-8, 2008.

Fan Y, Yang GY. Therapeutic angiogenesis for brain ischemia: a brief review.

J Neuroimmune Pharmacol. Sep;2(3):284-9, 2007.

Feiner JR, Severinghaus JW, Bickler PE. Dark skin decreases the accuracy

of pulse oximeters at low oxygen saturation: the effects of oximeter probe

type and gender. Anesth Analg. Dec;105(6 Suppl):S18-23, 2007.

Fiebig EW, Wu AH, Krombach J, Tang J, Nguyen KA, Toy P. Transfusion-

related acute lung injury and transfusion-associated circulatory overload:

mutually exclusive or coexisting entities? Transfusion. Jan;47(1):171-2,

2007.

Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological

and biochemical markers of alveolar epithelial barrier dysfunction in

perfused human lungs. Am J Physiol Lung Cell Mol Physiol. Jul;293(1):L52-9,

2007.

Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental

ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax.

Feb;63(2):147-53, 2008.

Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo

BJ, McCulloch CE, Young WL. Feasibility of minocycline and doxycycline use

as potential vasculostatic therapy for brain vascular malformations: pilot

study of adverse events and tolerance. Cerebrovasc Dis. 25(1-2):157-63,

2008.

Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D,

Niemann CU. Glutamine donor pretreatment in rat kidney transplants with

severe preservation reperfusion injury. J Surg Res. Jun 1;140(1):77-83,

2007.

Gabriel RA, Yang GY. Gene therapy in cerebrovascular diseases. Curr Gene

Ther. Dec;7(6):421-33, 2007.

Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS, Hooper VD, Kovac

AL, Kranke P, Myles P, Philip BK, Samsa G, Sessler DI, Temo J, Tramèr MR,

Vander Kolk C, Watcha M; Society for Ambulatory Anesthesia. Society for

Ambulatory Anesthesia guidelines for the management of postoperative

nausea and vomiting. Anesth Analg. Dec;105(6):1615-28, 2007.

Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE,

Prough DS, Baus D, Bepperling F, Warltier DC. Volume replacement therapy

during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4)

or hetastarch. Anesthesiology. Jun;106(6):1120-7, 2007.

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D,

Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta

causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-

dependent mechanisms. Circ Res. Apr 11;102(7):804-12, 2008.

Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P,

Christiaans SC, Bir ND, Pittet JF. ngiopoietin-2, marker and mediator of

endothelial activation with prognostic signifi cance early after trauma? Ann

Surg. Feb;247(2):320-6, 2008.

Gelb AW, Craen RA, Rao GS, Reddy KR, Megyesi J, Mohanty B, Dash HH,

Choi KC, Chan MT. Does hyperventilation improve operating condition during

supratentorial craniotomy? A multicenter randomized crossover trial. Anesth

Analg. Feb;106(2):585-94, 2008.

Gelb K, Gelb AW. Sex and gender in the perioperative period: wake up to

reality. Anesth Analg. Jul;107(1):1-3, 2008.

Gropper MA, Wiener-Kronish J. The epithelium in acute lung injury/acute

respiratory distress syndrome. Curr Opin Crit Care. Feb;14(1):11-5, 2008.

Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary

delivery of bone marrow-derived mesenchymal stem cells improves survival

and attenuates endotoxin-induced acute lung injury in mice. J Immunol Aug

1;179(3):1855-63, 2007.

Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil

depletion decreases VEGF-induced focal angiogenesis in the mature mouse

brain. J Cereb Blood Flow Metab. Nov;27(11):1853-60, 2007.

Hasegawa K, Hu C, Nakamura T, Marks JD, Russell SJ, Peng KW. Affi nity

thresholds for membrane fusion triggering by viral glycoproteins. J Virol.

Dec;81(23):13149-57, 2007.

Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J,

Niemann CU. Transient hyperglycemia affects the extent of ischemia-

ANESTHESIA NEWS 33

2006Lundy Campbell

Director, Thoracic Anesthesia, 2006

James Marks

Chief, SFGH, 2006

Manuel Pardo

Vice Chair for Education, 2006

Ronald D. Miller

President of Medical Staff,

UCSF Medical Center, 2006

UCSF PainCARE - Center for Advanced

Research and Education

Pamela Palmer

Critical Care Medicine and Trauma CME Course

Michael Gropper

reperfusion-induced renal injury in rats. Anesthesiology. Mar;108(3):402-14,

2008.

Hopf HW, Rollins MD. Wounds: an overview of the role of oxygen. Antioxid

Redox Signal. Aug;9(8):1183-92, 2007.

International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds

DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM,

Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W,

Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q,

Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A,

Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC,

Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z,

Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y,

Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB,

Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F,

Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A,

Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-

Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T,

Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda

T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S,

Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de

Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe’er I,

Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC,

Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson

GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan

W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin

N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M,

Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T,

Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I,

Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu

T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu

R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton

EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E,

Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ,

Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J,

Burton J, Carter NP, Clee CM, Griffi ths M, Jones MC, McLay K, Plumb RW,

Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg

JC, L’Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z,

Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson

JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson

R, Stewart J. A second generation human haplotype map of over 3.1 million

SNPs. Nature. Oct 18;449(7164):851-61, 2007.

Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA,

Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ. Duloxetine for

the management of diabetic peripheral neuropathic pain: evidence-based

fi ndings from post hoc analysis of three multicenter, randomized, double-

blind, placebo-controlled, parallel-group studies. Clin Ther. 29

Suppl:2536-46, 2007.

Kessler J, Gray AT. Sonography of scalene muscle anomalies for brachial

plexus block. Reg Anesth Pain Med. Mar-Apr;32(2):172-3, 2007.

Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol

AS, Lawton MT, Higashida RT, Young WL; UCSF BAVM Study Project. Racial/

Ethnic differences in longitudinal risk of intracranial hemorrhage in brain

arteriovenous malformation patients. Stroke. Sep;38(9):2430-7, 2007.

Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY,

Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric

oxide synthase polymorphism (-786T->C) and increased risk of angiographic

vasospasm after aneurysmal subarachnoid hemorrhage. Stroke.

Apr;39(4):1103-8, 2008.

Komatsu R, Turan AM, Orhan-Sungur M, McGuire J, Radke OC, Apfel CC.

Remifentanil for general anaesthesia: a systematic review. Anaesthesia.

Dec;62(12):1266-80, 2007.

Kreuer S, Bruhn J, Walter E, Larsen R, Apfel CC, Grundmann U, Biedler A,

Wilhelm W. Comparative pharmacodynamic modeling using bispectral and

narcotrend-index with and without a pharmacodynamic plateau during

sevofl urane anesthesia. Anesth Analg. Apr;106(4):1171-81, 2008.

Krombach J, Gray AT. Sonography for saphenous nerve block near the

adductor canal. Reg Anesth Pain Med. Jul-Aug;32(4):369-70, 2007.

Larson MD. Mechanism of opioid-induced pupillary effects. Clin

Neurophysiol. Jun;119(6):1358-64, 2008.

Laster MJ, Zhang Y, Eger EI 2nd, Shnayderman D, Sonner JM. Alterations in

spinal, but not cerebral, cerebrospinal fl uid Na+ concentrations affect the

isofl urane minimum alveolar concentration in rats. Anesth Analg.

Sep;105(3):661-5, 2007.

Lawton MT, Arnold CM, Kim YJ, Bogarin EA, Stewart CL, Wulfstat AA, Derugin

N, Deen D, Young WL. Radiation arteriopathy in the transgenic arteriovenous

fi stula model. Neurosurgery. May;62(5):1129-38, 2008.

Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL. Matrix metalloproteinase-9

inhibition attenuates vascular endothelial growth factor-induced intracerebral

hemorrhage. Stroke Sep;38(9):2563-8, 2007.

Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay

MA. Acute lung injury edema fl uid decreases net fl uid transport across

human alveolar epithelial type II cells. J Biol Chem. Aug

17;282(33):24109-19, 2007.

Lee JW, Matthay MA. Protein permeability in lung injury: now in real time

again? J Appl Physiol. Feb;102(2):508-9, 2007.

Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR.

Apolipoprotein E e4 allele increases the risk of early postoperative delirium

in older patients undergoing noncardiac surgery. Anesthesiology.

Sep;107(3):406-11, 2007.

Lieberman JA, Lyon R, Feiner J, Hu SS, Berven SH. The effi cacy of motor

evoked potentials in fi xed sagittal imbalance deformity correction surgery.


Contributions

Chairs, Chiefs,

and Directors


2006Laura Siedman

Associate Medical Director, Ambulatory

Surgery Center, 2006

C. Spencer Yost

Director, ICU, Mount Zion, 2006

John Taylor


Recovery of Airway Refl exes

following Inhaled Anesthetics

Rachel McKay Miller’s Anesthesia, 6th Edition

Spine. Jun 1;33(13):E414-24, 2008.

Liu B, Conrad F, Roth A, Drummond DC, Simko JP, Marks JD. Recombinant

full-length human IgG1s targeting hormone-refractory prostate cancer. J Mol

Med. Oct;85(10):1113-23, 2007.

Liu L, Gropper MA. Tracheostomy protocol compliance: herding cats? Crit

Care Med. Jun;36(6):1959-60, 2008.

Lynch SV, Yang K, Brodie EL, MacDougal C, Andersen GL, Wiener-Kronish JP.

Culture-Independent Bacterial Population Analysis - Clinical Implications for

Respiratory and Other Infections Curr Respir Med Rev. Feb;4(1):35-39, 2008.

Lynch SV, Wiener-Kronish JP. Novel strategies to combat bacterial virulence.

Curr Opin Crit Care. Oct;14(5):593-599, 2008.

Lynch SV, Dixon L, Benoit MR, Brodie EL, Keyhan M, Hu P, Ackerley DF,

Andersen GL, Matin A. Role of the rapA gene in controlling antibiotic

resistance of Escherichia coli biofi lms. Antimicrob Agents Chemother.

Oct;51(10):3650-8, 2007.

Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofi ore G,

Niemann C, Walia A, Vater Y, Tran ZV, Kam I. A multicenter evaluation of

safety of early extubation in liver transplant recipients. Liver Transpl.

Nov;13(11):1557-63, 2007.

Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE.

Interleukin-6 and atrial fi brillation in patients with coronary artery disease:

data from the Heart and Soul Study. Am Heart J. Feb;155(2):303-9, 2008.

McKay RE, Rapan R. Infl uence of body mass index on recover of protective

airway refl exes after anesthesia with desfl urane or sevofl urane. Eur J

Anaesthesiol. 25(Suppl 44):2AP2-7, 2008.

McKay RE, Rozner MA. Preventing pacemaker problems with nerve

stimulators. Anaesthesia. May;63(5):554-6, 2008.

Miller RD. Editorial, 4th Asian Esmeron Expert meeting (AEEM). ASEAN J.

Anaesthesiology 8:1-2, 2007.

Miller RD. Sugammadex May Replace Best Clinical Practice: A

Misconception Anesth Analg. Nov;105:(5):1507, 2007.

Miller RD. Sugammadex: an opportunity to change the practice of

anesthesiology? Anesth Analg. Mar;104(3):477-8, 2007.

Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM. Anesthetic-like

modulation of a gamma-aminobutyric acid type A, strychnine-sensitive

glycine, and N-methyl-d-aspartate receptors by coreleased

neurotransmitters. Anesth Analg. Aug;105(2):386-92, 2007.

Mok JM, Lyon R, Lieberman JA, Cloyd JM, Burch S. Monitoring of nerve root

injury using transcranial motor-evoked potentials in a pig model. Spine. Jun

15;33(14):E465-73, 2008.

Niemann CU, Serkova NJ. Biochemical mechanisms of nephrotoxicity:

application for metabolomics. Expert Opin Drug Metab Toxicol.

Aug;3(4):527-44, 2007.

Olivares M, Terwiesch C, Cassorla L. Structural Estimation of the

Newsvendor Model: An Application to Reserving Operating Room Time

Management Science 54(1):41-55, 2008.

Orhan-Sungur M, Kranke P, Sessler D, Apfel CC. Does supplemental oxygen

reduce postoperative nausea and vomiting? A meta-analysis of randomized

controlled trials. Anesth Analg. Jun;106(6):1733-8, 2008.

Ozgediz D, Kijjambu S, Galukande M, Dubowitz G, Mabweijano J, Mijumbi C,

Cherian M, Kaggwa S, Luboga S. Africa’s neglected surgical workforce crisis.

Lancet. 23;371(9613):627-8, 2008.

Ozgediz D, Galukande M, Mabweijano J, Kijjambu S, Mijumbi C, Dubowitz G,

Kaggwa S, Luboga S. The neglect of the global surgical workforce:

experience and evidence from Uganda. World J Surg. Jun;32(6):1208-15,

2008.

Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU.

Increased severity of renal ischemia-reperfusion injury with venous clamping

compared to arterial clamping in a rat model. Surgery Feb;143(2):243-51,

2008.

Phelps P, Cakmakkaya OS, Apfel CC, Radke OC. A simple clinical maneuver

to reduce laparoscopy-induced shoulder pain: a randomized controlled trial.

Obstet Gynecol. May;111(5):1155-60, 2008.

Pittet JF, Song Y, Wiener-Kronish JP. Treating lung infections with

anticoagulation: mechanisms matter. Crit Care Med. Jan;36(1):356-7, 2008.

Rayz VL, Lawton MT, Martin AJ, Young WL, Saloner D. Numerical simulation

of pre- and postsurgical fl ow in a giant basilar aneurysm. J Biomech Eng.

Apr;130(2):021004, 2008.

Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy

E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska

A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris

T, Zmuda JM, Ziv E; Health, Aging and Body Composition (Health ABC) Study.

Admixture mapping of an allele affecting interleukin 6 soluble receptor and

interleukin 6 levels. Am J Hum Genet. Apr;80(4):716-26, 2007.

Rosales CM, Young T, Laster MJ, Eger EI 2nd, Garg U. Sevofl urane

concentrations in blood, brain, and lung after sevofl urane-induced death. J

Forensic Sci. Nov;52(6):1408-10, 2007.

Roth A, Drummond DC, Conrad F, Hayes ME, Kirpotin DB, Benz CC, Marks

JD, Liu B. Anti-CD166 single chain antibody-mediated intracellular delivery

of liposomal drugs to prostate cancer cells. Mol Cancer Ther.

Oct;6(10):2737-46, 2007.

ANESTHESIA NEWS 35

2007Roland Bainton

Member, Program in Biologic

Sciences, 2007

John Kulli

Perioperative Medical Director,

2007

Lee-lynn Chen

Acting Chief, Mount Zion, 2007

Implements National Anesthesia, ICU,

Analytic Electronic Information System for VAH

Gerard Ozanne

NIH Training Grant

Jean-François Pittet

(Young W)

Serkova NJ Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell

MS. Early detection of graft failure using the blood metabolic profi le of a liver

recipient. Transplantation. Feb 27;83(4):517-21, 2007.

Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno-

associated viral vector-mediated hypoxia-regulated VEGF gene transfer

promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther.

Jan;15(1):30-9, 2008.

Shiga T, Apfel CC, Wajima Z, Ohe Y. Infl uence of intraoperative conversion

from off-pump to on-pump coronary artery bypass grafting on costs and

quality of life: a cost-effectiveness analysis. J Cardiothorac Vasc Anesth.

Dec;21(6):793-9, 2007.

Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L,

Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the

organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin

Pharmacol Ther. Feb;83(2):273-80, 2008.

Singh V, Smith WS, Lawton MT, Halbach VV, Young WL. Risk factors for

hemorrhagic presentation in patients with dural arteriovenous fi stulae.

Neurosurgery. Mar;62(3):628-35, 2008.

Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith

LA, Marks JD, Xie G, Brettin TS. Analysis of the Neurotoxin Complex Genes

in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1

Clusters Are Located within Plasmids. PLoS ONE. Dec 5;2(12):e1271, 2007.

Song Y, Pittet JF, Huang X, He H, Lynch SV, Violette SM, Weinreb PH, Horan

GS, Carmago A, Sawa Y, Bernstein XL, Wiener-Kronish JP. Role of integrin

alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa.

Infect Immun. Jun;76(6):2325-32, 2008.

Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL,

Fanselow MS, Eger EI 2nd, Homanics GE. Effect of isofl urane and other

potent inhaled anesthetics on minimum alveolar concentration, learning, and

the righting refl ex in mice engineered to express alpha1 gamma-

aminobutyric acid type A receptors unresponsive to isofl urane.

Anesthesiology. Jan;106(1):107-13, 2007.

Sonner JM. A hypothesis on the origin and evolution of the response to

inhaled anesthetics. Anesth Analg. Sep;107(3):849-54, 2008.

Sonner JM. Ethnicity can affect anesthetic requirement. Anesthesiology.

Jul;107(1):4-5, 2007.

Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C. Organization

and function of the blood-brain barrier in Drosophila. J Neurosci. Jan

16;28(3):587-97, 2008.

Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A,

Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF,

Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL,

Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH,

Jankowska I, Pawłowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson

RJ. Severe bile salt export pump defi ciency: 82 different ABCB11 mutations

in 109 families. Gastroenterology. Apr;134(4):1203-14, 2008.

Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK,

Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5

regulates lung vascular permeability and pulmonary endothelial barrier

function. Am J Respir Cell Mol Biol. Mar;36(3):377-86, 2007.

Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G,

Grossman W, Kan YW. AAV serotype 1 mediates more effi cient gene transfer

to pig myocardium than AAV serotype 2 and plasmid. J Gene Med.

Jan;10(1):33-41, 2008.

Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible

gene expression in ischemic hearts. Methods Mol Biol. 366:331-42, 2007.

Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay

MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury

in mice and rats. Am J Respir Cell Mol Biol. Aug;37(2):186-92, 2007.

Talke PO, Maze M. Expecting the unexpected. Anesth Analg.

Jun;106(6):1605-6, 2008.

Tang Y, Lou J, Alpaugh RK, Robinson MK, Marks JD, Weiner LM. Regulation

of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent

affi nity for target antigen. J Immunol. Sep 1;179(5):2815-23, 2007.

Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan

K, Kwok PY, Whooley MA, Conklin BR. Gene-trapped mouse embryonic stem

cell-derived cardiac myocytes and human genetics implicate AKAP10 in

heart rhythm regulation. Proc Natl Acad Sci U S A. May 15;104(20):8461-6,

2007.

Tseng ZH, Aouizerat BE, Pawlikowska L, Vittinghoff E, Lin F, Whiteman D,

Poon A, Herrington D, Howard TD, Varosy PD, Hulley SB, Malloy M, Kane J,

Kwok PY, Olgin JE. Common beta-adrenergic receptor polymorphisms are

not associated with risk of sudden cardiac death in patients with coronary

artery disease. Heart Rhythm. Jun;5(6):814-21, 2008.

Tsui JY, Collins AB, White DW, Lai J, Tabas JA. Videos in clinical medicine.

Placement of a femoral venous catheter. N Engl J Med. Jun 26;358(26):e30,

2008.

Turatti F, Figini M, Balladore E, Alberti P, Casalini P, Marks JD, Canevari S,

Mezzanzanica D. Redirected activity of human antitumor chimeric immune

receptors is governed by antigen and receptor expression levels and affi nity

of interaction. J Immunother. Oct;30(7):684-93, 2007.

Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM,

Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic

cation transporter, OCTN1, on the renal clearance of gabapentin. Clin

Pharmacol Ther. Mar;83(3):416-21 2008.


Contributions

Chairs, Chiefs,

and Directors


Susan Lee

Interim Director,

Pain Management, VAH, 2007

Renee Navarro

Director, Academic Diversity, 2007

Basics of Anesthesia, 5th Edition,

Editor, Ronald D. Miller

Most Chapters Written by

Members of the Department

Pain Management Center Award

Clinical Center of Excellence from the

American Pain Society

Pamela Palmer

2007

Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA,

Guccione JM. Magnetic resonance imaging-based fi nite element stress

analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc

Surg. May;135(5):1094-102, 1102.e1-2, 2008.

Wang Y, Jiang L, Guo X, Gelb AW, Yue Y; Chinese Society of Anesthesiology.

The Chinese Society of Anesthesiology: 2006 annual meeting. Anesth Analg.

Oct;105(4):1132-5, 2007.

Wang Y, Gelb AW, Yue Y. The Chinese Society of Anesthesiology: 2007 Annual

Meeting report. Anesth Analg. Jun;106(6):1853-4, 2008.

Weigle DS, Buben A, Burke CC, Carroll ND, Cook BM, Davis BS, Dubowitz G,

Fisher RE, Freeman TC, Gibbons SM, Hansen HA, Heys KA, Hopkins B, Jordan

BL, McElwain KL, Powell FL, Reinhart KE, Robbins CD, Summers CC, Walker

JD, Weber SS, Weinheimer CJ. Adaptation to altitude as a vehicle for

experiential learning of physiology by university undergraduates. Adv Physiol

Educ. Sep;31(3):270-8, 2007.

Weiskopf RB. Recombinant-activated coagulation factor VIIa (NovoSeven):

current development. Vox Sang. May;92(4):281-8, 2007.

Weiskopf RB. The ethics of blood management. Vox Sang. Jul;93(1):91,

2007.

Wong-Beringer A, Wiener-Kronish J, Lynch S, Flanagan J. Comparison of

type III secretion system virulence among fl uoroquinolone-susceptible and

-resistant clinical isolates of Pseudomonas aeruginosa. Clin Microbiol Infect.

Apr;14(4):330-6, 2008.

Xue Q, Schumacher MA. New insights into the role of the capsaicin receptor

(TRPV1) in infl ammatory pain. CellScience 3: 1-6, 2007.

Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1 utilizes

a dual promoter system that is positively regulated by nerve growth factor. J

Neurochem. Apr;101(1):212-22, 2007.

Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM.

Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and

acetone. Anesth Analg. Sep;105(3):673-9, 2007.

Yang L, Sonner JM. Anesthetic-like modulation of receptor function by

surfactants: a test of the interfacial theory of anesthesia. Anesth Analg.

Sep;107(3):868-74, 2008.

Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on

wild-type and mutant gamma-aminobutyric acid type A and glycine

receptors. Anesth Analg. Mar;106(3):838-45, 2008.

Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer

di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and

glycine receptor function. Anesth Analg. Aug;105(2):393-6, 2007.

Yoo J, Tcheurekdjian H, Lynch SV, Cabana M, Boushey HA. Microbial

manipulation of immune function for asthma prevention: inferences from

clinical trials. Proc Am Thorac Soc. Jul;4(3):277-82, 2007.

Yost CS, Gropper MA. The curse of the drinking class. Crit Care Med.

Jun;36(6):1958-9, 2008.

Young WL, Kwok PY, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk

DA. Arteriovenous malformation. J Neurosurg. Apr;106(4):731-2 2007.

Young WL. Anesthesia for endovascular neurosurgery and interventional

neuroradiology. Anesthesiol Clin. Sep;25(3):391-412, vii, 2007.

Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. Exogenous ethyl pyruvate

versus pyruvate during metabolic recovery after oxidative stress in neonatal

rat cerebrocortical slices. Anesthesiology Oct;107(4):630-40, 2007.

Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A,

Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace

AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical

left ventricular aneurysm increases systolic circumferential shortening in

sheep. J Thorac Cardiovasc Surg. Oct;134(4):1017-24, 2007.

Zhang Y, Laster MJ, Eger EI 2nd, Sharma M, Sonner JM. Blockade of

acetylcholine receptors does not change the dose of etomidate required to

produce immobility in rats. Anesth Analg. Apr;104(4):850-2, 2007.

Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD.

Impact of single-chain Fv antibody fragment affi nity on nanoparticle

targeting of epidermal growth factor receptor-expressing tumor cells. J Mol

Biol. Aug 24;371(4):934-47, 2007.

Zhu W, Tian Y, Zhou LF, Wang Y, Song D, Mao Y, Yang GY. Development of a

novel endothelial cell-seeded endovascular stent for intracranial aneurysm

therapy. J Biomed Mater Res A. Jun 1;85(3):715-21, 2008.

Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y.

Insulin growth factor-1 gene transfer enhances neurovascular remodeling

and improves long-term stroke outcome in mice. Stroke. Apr;39(4):1254-61,

2008.

Zhu W, Khachi S, Hao Q, Shen F, Young WL, Yang GY, Chen Y. Upregulation of

EMMPRIN after permanent focal cerebral ischemia. Neurochem Int.

May;52(6):1086-91, 2008.

Zhuo H, Yang K, Lynch SV, Dotson RH, Glidden DV, Singh G, Webb WR,

Elicker BM, Garcia O, Brown R, Sawa Y, Misset B, Wiener-Kronish JP.

Increased mortality of ventilated patients with endotracheal Pseudomonas

aeruginosa without clinical signs of infection. Crit Care Med.

Sep;36(9):2495-503, 2008. ■

ANESTHESIA NEWS 37

Martin Stechert

Director, Respiratory Therapy, VAH, 2007

Manuel Pardo

Director, UCSF Kanbar Simulation Center, 2007

Jens Krombach

Perioperative Director, SFGH, 2008

Mechanisms of Inhaled Anesthetic Actions

James Sonner

Identifi cation of Protein C Activation as a Critical Mechanism for

Development of Early Coagulopathy in Trauma Patients

Jean-François Pittet

(Chesebro B, Cohen M)

2008

Active Research Grants

Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award

Apfel, Christian Principal Investigator Merck & Co, Inc. Individual Rsch Grant Development of a Predictive Model for Post-Discharge Nausea and

Vomiting (PDNV)

06/01/07 - 05/31/08 $727,538

Apfel, Christian Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double Dummy, Dose-Ranging, Active-and

Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the

Prevention of Postoperative Nausea and Vomiting (PONV)

08/01/07 - 07/31/08 $116,499

Apfel, Christian Principal Investigator Anesiva, Inc Clinical Trial A multicenter, randomized, double-blind, placebo-controlled, parallel-group

study to evaluate effi cacy, safety and tolerability of a single intraoperative

localized instillation of 4975 in patients undergoing primary unilateral total

hip arthroplasty

04/30/08-06/30/09 $132,288

Apfel, Christian Principal Investigator Anesiva, Inc IndivRschGrant/Contract A Phase 3, Multicenter, Randomized, Placebo-Controlled, Parallel-Group,

Double-Blind Study to Evaluate the Effi cacy, Tolerability, Safety, and

Pharmacokinetics of 4975 in Patients Undergoing Primary Unilateral Total

Knee Arthroplasty

04/30/08 - 06/30/09 $209,282

Bainton, Roland Principal Investigator NIGMS/NIH Individual Rsch Grant Physiology aand Regulation of Drug Transport Across the Blood Brain

Barrier

08/01/07 - 05/31/12 $1,456,540

Bainton, Roland Principal Investigator EON Research Corporation Subcontract Blood Brain Barrier Modulators 04/01/08 - 09/30/09 $167,400

Behrends, Matthias Principal Investigator REAC/Springer H Mem FDN Individual Rsch Grant Reduction of Hepatic Ischemia/Reperfusion Injury by Short-Term

Pretreatment with Simvastatin

03/01/07 - 02/28/09 $25,000

Bickler, Philip Principal Investigator NIGMS/NIH Individual Rsch Grant Intracellular Signaling in Anesthetic and Hypoxic Preconditioning of

Neurons

04/01/07 - 02/28/11 $1,241,507

Bickler, Philip Principal Investigator University of Alaska Subcontract Advancing UAF SNRP 05/01/06 - 04/30/11 $368,781

Bickler, Philip Principal Investigator Various Industry Sponsors Other Clinical Contract Accuracy of Pulse Oximeters with Profound Hypoxia 09/01/86 - Present Varies per

contract

Chen, Yongmei Principal Investigator NINDS/NIH Individual Rsch Grant Del-1 Induces Therapeutic Cerebral Angiogenesis 05/01/06 - 10/30/08 $365,576

Chen, Yongmei Principal Investigator American Heart Association

(AHA)

Individual Rsch Grant Netrin-1 in Neurovascular Regeneration 07/01/08 - 06/30/10 $140,000

Dubowitz, Gerald Principal Investigator Mt. Zion Health Fund Individual Rsch Grant Safety and Acceptability of IV method (UCSF Invention SF2006-14) in

Operative and Critical Care Anesthesia Practice

04/01/08 - 03/31/09 $40,500

Eger, Edmond Principal Investigator NIGMS/NIH Specialized Center Grant Sites & Mechanisms of Inhaled Anesthetic Actions 08/01/04 - 07/31/09 $7,321,207

Eilers, Helge Principal Investigator Hellman Family Awards Individual Rsch Grant Anesthetic Effects on Peripheral Nociceptors 01/01/08 - 12/31/08 $40,000

Gelb, Adrian Principal Investigator Hospira, Inc. Individual Rsch Grant Depth of Anesthesia with the Sedline Facilitates Motor Evoked Potential

(MEP) Monitoring During Corrective Spinal Surgery

12/19/07 - 12/19/09 $80,000

Gelb, Adrian Principal Investigator Johnson and Johnson Clinical Trial A Randomize, Double-Blind, Active- and Placebo-Controlled, Parallel

Group, Multicenter Study to Evaluate the Effi cacy and Safety of Multiple

Doses of CG5503 Immediate-Release Formulation in the Treatment of

Acute Pain from Tota

12/08/06 - 06/30/08 $235,400

Gropper, Michael Project Leader #2 NHLBI/NIH Specialized Center Grant Transfusion and Lung Injury (SCCOR Grant) 09/30/05 - 08/31/10 $825,757

Hashimoto, Tomoki Principal Investigator NINDS/NIH Individual Rsch Grant Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling

and Infl ammation

02/01/07 - 01/31/11 $1,282,367

Hashimoto, Tomoki Principal Investigator American Heart Association

(AHA)

Individual Rsch Grant/

Cooperative Agreement

Pathophysiology of Intracranial Aneurysms - Roles of Macrophages and

Vascular Remodeling

07/01/07 - 06/30/09 $140,000

Houseman, Benjamin Principal Investigator Helen Diller Family

Comprehensive Cancer Center

Individual Rsch Grant Using microfl uidic technology to study dynamic kinase inhibitor therapy 07/01/08 - 06/30/09 $30,000

Howard, Marybeth Principal Investigator Academic Senate Individual Rsch Grant Regulation of STAT1 Signaling Pathway by the Stress of Protein Response 07/15/06 - 07/14/08 $28,000

Kim, Helen Principal Investigator REAC/Huntington G & S

MEM FD

Individual Rsch Grant Whole Genome Amplifi cation of Archived, Paraffi n-Embedded AVM Tissue 03/01/07 - 02/28/09 $25,459

Kim, Helen Principal Investigator American Heart Association

(AHA)

Individual Rsch Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous

Malformations

07/01/07 - 06/30/08 $65,000

Kim, Helen Principal Investigator NINDS/NIH Instruction Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous

Malformations

07/01/08 - 06/30/13 $782,716

Lee, Chanhung Principal Investigator American Heart Association

(AHA)

Individual Rsch Grant Infl uence of Matrix Metalloproteinase on Brain Arteriovenous Malformation

Hemorrhage

01/01/07 - 12/31/10 $260,000

Lee, Jae Woo Principal Investigator Foundation for Anesthesia

Education & Research (FAER)

Instruction Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury in Primary

Cultures of Human Alveolar Epithelial Type II Cells and in the Ex Vivo

Perfused Human Lung

01/01/08 - 12/31/08 $115,000

Lee, Jae Woo Principal Investigator NHLBI/NIH Individual Rsch Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury 08/04/08 – 07/31/13 $608,850

Leung, Jacqueline Principal Investigator Anesthesia Patient Safety

Foundation (APSF)

Individual Rsch Grant Pathophysiology of Postoperative Delirium 01/01/08 - 06/30/09 $149,800

Litt, Lawrence Principal Investigator NIGMS/NIH Individual Rsch Grant 2D NMR of Energy Rescue from PARP in Brain Slice Hypoxia 06/01/04 - 05/31/09 $1,332,605

Liu, Bin Principal Investigator NCI/NIH Individual Rsch Grant Mapping a Clinically Signifi cant Internalizing Tumor Epitope Space 03/07/06 - 1/31/11 $1,334,984

Liu, Bin Principal Investigator DOD/Army Ovarian Cancer

Research Program

Individual Rsch Grant Defi ning and Targeting of an Ovarian Cancer Spefi cic Internalizing Epitope

Space

01/01/04 - 10/31/08 $664,066

Liu, Bin Principal Investigator Mesothelioma Applied

Research Foundation (MARF)

Individual Rsch Grant Identifi cation of Mesothelioma Specifi c Cell Surface Antigens 01/01/07 - 12/31/08 $100,000

Liu, Bin Principal Investigator American Association for

Cancer Research/AACR

Individual Rsch Grant Internalizing Human Antibodies Targeting Pancreatic Tumor Cells in Situ 07/01/08 - 06/30/10 $100,000

London, Martin Principal Investigator Anesthesia Patient Safety

Foundation (APSF)

Individual Rsch Grant Perioperative Pharmacologic Prophylaxis for Cardiovascular Events in the

Dept of Veterans Affairs: A Pharmacoepidemiologic Pilot Project

01/01/06 - 12/31/08 $75,000

Lynch, Susan Principal Investigator American Lung Association

(ALA)

Individual Rsch Grant Analysis of Bacterial Community Dynamics in Adult Patients with

Exacerbations of Chronic Objective Pulmonary Disease: The Effect of

Microbial Community Composition on Pathogen Abundance and Patient

Health

07/01/07 - 06/30/09 $80,000

Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc Individual Rsch Grant Collection of Clinical Respiratory Samples and Pseudomonas Aeuruginosa

for Validation of a Novel Culture Independent Diagnostic

01/07/08 - 10/16/08 $54,647

Lynch, Susan Principal Investigator NIAID/NIH Individual Rsch Grant Resequencing Microarray for Rapid Detection & Antimicrobial Resistance

Profi ling

08/01/07 - 07/31/12 $3,562,568

Lynch, Susan Principal Investigator NHLBI/NIH Individual Rsch Grant Gene Expression and Pathogenicity of P. Aeruginosa 12/11/03 - 11/30/08 $1,465,957

Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effect of Humanized anti PcrV Antibody on Total Bacterial Community

Composition of Adult Patients with Cystic Fibrosis

03/01/08 - 02/28/09 $152,415


Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award

Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Project #2: Effect of Humanized anti PcrV Antibody on Total Bacterial

Community Composition of Adult Patients with Cystic Fibrosis

07/01/08 - 06/30/09 $133,514

Marks, James Principal Investigator DTRA/DOD Defense Threat

Reduction Agency

IndivRschGrant/Contract Antibody Based Therapy for Botulism 01/18/07 - 01/17/10 $1,187,549

Marks, James Principal Investigator PHS Centers for Disease

Control (CDC)

Individual Rsch Grant Preparation of High Affi nity Monoclonal Antibodies for Use with the

Endopep MS Assay to Detect and Differentiate Botulinum Neurotoxins

07/01/06 - 05/31/09 $1,075,166

Marks, James Project Leader #5 NCI/NIH Specialized Center Grant Phage Display Antibodies (SPORE-BREAST) 03/01/03 - 06/30/08 $1,060,697

Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy 07/15/03 - 12/31/08 $5,040,609

Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy, Setotypes C, D,

F, and G

08/15/07 - 07/31/12 $3,782,514

Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Murine-Specifi c Targeting Ligands for Transcytosis

Through the Blood-Brain Barrier

06/01/07 - 05/31/08 $108,731

Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Novel Human-Specifi c Targeting Ligands for Transcytosis

Through the Blood-Brain Barrier

06/01/07 - 05/31/09 $472,763

Marks, James Principal Investigator XOMA Subcontract Development of a Final Drug Product for a Mixture of Monoclonal

Antibodies for Type A Botulinum Neurotoxins

09/06/06 - 07/27/09 $956,891

Marks, James Principal Investigator Genomic Systems IndivRschGrant/Contract Human Antibodies to PDGFR for Cancer Therapy 06/28/07 - 06/27/12 $102,359

Marks, James Principal Investigator DOD/IDEA Individual Rsch Grant Engineering Anti-EGFR Antibodies for Treatment of Brease Cancers With

Poor Prognosis

09/01/07 - 09/30/10 $463,144

Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Adaptive Immunity from High Affi nity Anti-HER2/neu Monoclonal Antibodies 09/01/06 - 06/30/11 $382,832

Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Defi ning the Role of Affi nity in Antibody-Based Tumor Targeting and

Therapy

02/05/07 - 01/31/12 $812,588

Marks, James Principal Investigator Functional Genetics Subcontract Determining the Impact of Epitope and Affi nity of TSG101 Antibodies on

Anti-Viral Activity

06/23/06 - 09/01/08 $263,922

Marks, James Principal Investigator The Lustgarten Foundation for

Pancreatic Research

Individual Rsch Grant Lustgarten Foundation for Pancreatic Cancer Research Biomarker Initiative 04/01/08 - 09/30/09 $306,171

McKay, Rachel Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double-Dummy, Dose-Ranging, Active-and

Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the

Prevention of Postoperative Nausea and Vomiting (PONV)

09/01/07 - 08/31/08 $113,399

Niemann, Claus Principal Investigator International Anesthesia

Research Society (IARS)

Individual Rsch Grant Ischemia Reperfusion Injury During Total Knee Athroplasty: The Impact of

Metabolic Syndrome

01/01/07 - 12/31/08 $80,000

Niemann, Claus Principal Investigator HRSA Individual Rsch Grant Intensive Insulin Therapy in Deceased Donors to Improve Renal Allograft

Function and Transplanted Allograft Outcomes

09/01/08 - 08/31/11 $821,251

Palmer, Pamela Principal Investigator The Mayday Fund Instruction Grant Pain CARE Center 06/01/05 - 05/31/08 $179,400

Pittet, Jean Principal Investigator NIGMS/NIH Individual Rsch Grant Stress Preconditioning and Alveolar Epithelial Injury 12/01/06 - 11/30/10 $1,045,089

Pittet, Jean Project Leader #4 NIGMS/NIH Specialized Center Grant TGF-Beta and Lung Epithelial Injury (SCCOR GRANT) 09/30/03 - 06/30/08 $1,769,262

Pittet, Jean Program Director NIGMS/NIH Training Grant Comprehensive Anesthesia Research Training 07/01/07 - 06/30/12 $933,595

Pittet, Jean Principal Investigator InCode BioPharmaceutics, Inc. IndivRschGrant/Contract Compliment Inhibition and Protein C Pathway 5/13/08-5/12/09 $29,355

Rollins, Mark Principal Investigator Foundation for Anesthesia


Instruction Grant A Comparison of Tissue Oxygen Levels in Multiple Organs During

Isovolemic Hemodilution with Right and Left-Shifted Hemoglobin-Based

Blood Substitutes

01/01/06 - 12/31/08 $255,000

Rollins, Mark Principal Investigator Anesthesia Patient Safety

Foundation (APSF)

Individual Rsch Grant Supplemental Oxygen: A Reduction in Pulse Oximetry Sensitivity or an

Increased Margin of Safery

01/01/08 - 12/31/08 $150,000

Roux, Jeremie Principal Investigator American Lung Association

(ALA)

Fellowhsip Grant Role of Stress Protein Response on IL-1 Beta-Mediated Inhibition on ENaC

Expression and Function in Lung Epithelial Cells

07/01/06 - 06/30/08 $65,000

Sall, Jeffrey Principal Investigator Foundation for Anesthesia


Instruction Grant Volatile Anesthetic Toxicity in Hippocampal Derived Progenitor Cells 01/01/07 - 12/31/08 $255,000

Schumacher, Mark Principal Investigator National Headache Foundation Individual Rsch Grant Regulation of Capsaicin Receptor (TRPV1) Expression in Meningeal

Sensory Neurons Under Infl ammatory Conditions

04/01/08 - 03/31/09 $16,000

Song, Yuanlin Principal Investigator Academic Senate Individual Rsch Grant Role of PAI-1 in Acute Lung Injury Induced by P. Aeruginosa 03/01/08 - 02/28/09 $23,876

Song, Yuanlin Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effi cacy of MAB166 as an Adjuvant Therapy to Standard of Care

Antimicrobial Therapy in a Mouse Model of Acute Lung Injury

01/08/08 - 07/08/08 $86,884

Sonner, James Principal Investigator NIGMS/NIH Individual Rsch Grant Genes Underlying the Response to Inhaled Anesthetics 07/15/04 - 06/30/09 $2,061,572

Stratmann, Greg Principal Investigator Anesthesia Patient Safety

Foundation (APSF)

Individual Rsch Grant Effectiveness of Three Clinically Applicable Strategies to Improve Safety of

Neonatal Anesthesia

01/01/07 - 12/31/08 $150,000

Su, Hua Princpal Investigator American Heart Association

(AHA)

Individual Rsch Grant Bone Marrow Mesenchymal Stem Cell Mediated Hypoxia-Responsive

Angiogenic Gene and Cell Therapy for Ischemic Heart

07/01/05 - 06/30/09 $260,000

Tang, Julin Principal Investigator Pfi zer US Pharmaceuticals Clinical Trial Linezolic in the Treatment of Subjects with Nosocomial Pneumonia Proven

to be Due to Methicillin-Resistant Staphylococcus Aureus

03/24/06 - 12/31/08 $207,194

Tang, Julin Principal Investigator Hospira, Inc. Individual Rsch Grant A Prospective, Randomized, Controlled Study on the Use of

Dexmedetomidine to Facilitate Extubation in Surgical Intensive-Care Unit

Patients Who Failed Previous Weaning Attempts Following Prolonged

Mechanical Ventilation

09/24/07 - 09/23/10 $154,966

Tang, Julin Principal Investigator Ortho-McNeil, Inc Clinical Trial A Phase 2, Open-Label, Non-Comparative Study of Doripenem in the

Treatment of Nosocomical and Ventillator-Associated Pneumonia in

Hospitals Where Pseudomonas Aeruginosa May Be A Prevalent Pathogen

05/21/07 - 8/31/08 $121,705

Yang, Guo-Yuan Principal Investigator The Sturge-Weber Foundation Individual Rsch Grant Development of Cerebrovascular Dysplasia Model for SWS Study 08/01/07 - 07/31/08 $60,000

Yost, Charles Principal Investigator NIGMS/NIH Individual Rsch Grant Background Potassium Channels as Anesthetic Targets 03/03/06 - 02/28/09 $888,576

Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 07/01/08 - 06/30/13 $1,974,062

Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Hemodynamics of Cerebral Arteriovenous Malformations 06/01/05 - 04/30/09 $1,302,842

Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 09/01/05 - 06/30/09 $1,401,376

Young, William Program Director NINDS/NIH Program Project Grant Integrative Study of Brain Vascular Malformations 09/30/03 - 06/30/09 $6,487,825

Young, William Principal Investigator Columbia University Clinical Trial Sub Award A Randomized Trial of Unruptured Brain Arteriovenous Malformations 01/13/06 - 07/31/11 $288,600

Young, William Principal Investigator The Aneurysm and AVM

Foundation/TAAF

Individual Rsch Grant PET and Magnetic Resonance Modeling to Assess the Risk of

Aneurysm Rupture

11/01/07 - 10/31/09 $50,000

Young, William and

Yang, Guo-Yuan

Project Leaders California Institute for

Regenerative Medicine/CIRM

Specialized Center Grant Human Stem Cell Derived Oligodendrocytes for Treatment of

Stroke and MS

08/01/07 - 07/31/11 $200,000

ANESTHESIA NEWS 39

UCSF Center For

Cerebrovascular

Research CCR/PPG

Seminars

Presented by the Center for

Cerebrovascular Research

Department of Anesthesia and

Perioperative Care


San Francisco General Hospital

For a list of upcoming seminars:

http://avm.ucsf.edu/

For a list of past seminars:

http://avm.ucsf.edu/research/recent_seminars.html

Critical Care Medicine and

Trauma 2009

May 28-May 30, 2009

InterContinental Mark Hopkins Hotel

San Francisco, California

Course Director:

Michael A. Gropper, MD, PhD

Professor and Vice Chair


Perioperative Care

Director, Critical Care Medicine

UCSF Medical Center

Course Co-Chairs:

Rochelle Dicker, MD

Assistant Professor in Residence

Department of Surgery


Mark Eisner, MD, MPH

Associate Professor

Department of Anesthesia, Department

of Medicine Division of Occupational and

Environmental Medicine and Division of

Pulmonary and Critical Care Medicine

UCSF Medical Center

Julin Tang, MD, MS

Clinical Professor


Director, Critical Care Medicine


Program and registration information:

www.cme.ucsf.edu

Department Chairman

Editor-in-Chief

Ronald D. Miller, MD

Executive Editor:

Marge O’Halloran

Editor:

Morgen Ahearn

Designer:

UCSF Documents, Media & Mail

Principal Writer:

Andrew Schwartz

Photographers:

Michael Lee

Christine Jegan

Marco Sanchez

Richard Schlobohm

Brant Ward

Various UCSF Anesthesia Staff

Anesthesia NewsNon-Profi t Org.

U.S. Postage

PAID

University of California

San Francisco


Perioperative Care Grand Rounds

First and Third Wednesdays

of every month

6:30 a.m.-8:00 a.m.

Room C 701,

521 Parnassus Ave.

San Francisco, California

www.anesthesia.ucsf.edu


Perioperative Care

310

University of California

San Francisco

Box 0648

San Francisco, CA 94143-0648