c v i . s ta n fo rd .e d u | 1

New CVI StaffAruna Krishnan, PhD Senior Research Scientistakrish@stanford.eduDr. Krishnan has over 30 years of research experience studying the en-docrine system in physiology and disease in the areas of molecular and cellular biology. Her research interests include understanding the role of nuclear receptors in normal physiology and the changes in their sig-naling in disease states such as diabetes and cancer. Her research has

resulted in over 70 publications in leading peer-reviewed journals and edited books.

Katy Claiborn, PhD Senior Researcher/Writerclaiborn@stanford.eduDr. Claiborn trained in molecular biology at the University of Pennsyl-vania, focused on glucose metabolism and pancreatic development. She has a passion for scientific communication, and previously served as an editor at the Journal of Clinical Investigation and as a Research Associate at the Harvard School of Public Health.

SPRING 2017

Faculty Recruitment The Cardiovascular Institute and the De-partment of Medicine at Stanford Univer-sity are recruiting a full-time academic faculty with expertise in any of the areas of drug/gene delivery, polymer chemistry/nanotechnology, bioengineering/bioma-terial sciences, biomedical formulation, clinical medicinal chemistry, medical pharmacology/molecular pharmacology, toxicology, bioinformatics, applied pro-teomics and pharmacogenomics at the rank of Assistant or Associate Professor in the Non-Tenured Line-Research (NTL-R). Contact: Mark Mercola, PhD, mmercola@stanford.edu.

Welcome New Faculty!Dr. Ronglih Liao joins Stanford as a Pro-fessor in the Depart-ment of Medicine and a new member of the Cardiovascular Insti-tute. Dr. Liao arrives from Harvard Med-ical School and Brigham and Women’s Hospital, where she was a Professor of Medicine and a principal faculty mem-ber of the Harvard Stem Cell Institute. Dr. Liao’s previous work broke important ground in establishing the therapeutic potential of delivering primitive mus-cle cells to repair damaged heart tissue. Her laboratory continues to pursue this avenue, seeking to harness the poten-tial of stem and progenitor cells and the endogenous repair capacity of the heart to treat cardiovascular disease. In addi-tion, Dr. Liao is unraveling the molecular mechanisms that underlie primary amy-loid cardiomyopathy. She will establish a multi-disciplinary and collaborative basic and translational amyloid research program at Stanford.

Third Annual StanfordDrug Discovery Conference April 23-24, 2018

The CVI leadership is excited to announce that next year’s event will include presentations from leaders of major pharmaceutical com-panies, federal and foundation policy mak-ers, and scientists making groundbreaking advances in the drug discovery space. High-lights include: the presentation of a Lifetime Achievement Award to Dr. Roy Vagelos (for-mer CEO of Merck and current Chair of Regen-

eron); a Keynote Address from Dr. Brian Kobilka (Nobel Prize in Chemistry, 2012); a Fireside Chat with Stanford University President Marc Tessier-Lavigne, PhD, and Stanford School of Medicine Dean Lloyd Minor, MD; a panel discussion with editors representing the New England Journal of Medicine, JAMA, Science, and Nature Reviews Drug Discovery; and View from the Top presentations by biotechnology industry leaders Ken Frazier (CEO of Merck), Bob Bradway (CEO of Amgen) Joe Jimenez (Former CEO of Novartis), Jeff Leiden (CEO of Vertex), Patrick Soon-Shiong (CEO of Nantworks), and George Scangos (CEO of Vir).

In addition, researchers engaged in clinical and translational stage projects will have the opportunity to present their ideas in an interactive shark-tank style competition judged by a panel of CEOs.

For more information, see http://med.stanford.edu/cvi/mission/upcoming-events/2018-drug-discov-ery-conference.html

FALL 2017

Roy Vagelos, MD

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2018 Drug Discovery ConferenceApril 23-24, 2018

Li Ka Shing Conference Center

The Institute currently consists of over 241 faculty members representing physicians, surgeons, engineers,

basic and clinical researchers. The mission of the Institute is integrating fundamental research across disci-

plines and applying technology to prevent and treat cardiovascular disease.

To support cardiovascular research and education at CVI, please contact: Cathy Hutton, Senior Associate

Director, Medical Center Development at cathy.hutton@stanford.edu

For more information: http://med.stanford.edu/cvi/support-our-research.html and http://cvi.stanford.edu

About the Stanford Cardiovascular Institute

Cathy Hutton, MBA

Kenneth Frazier CEO, Merck

Roy Vagelos, MD Former CEO, Merck

Bob Bradway CEO, Amgen

Jeff Leiden, MD CEO, Vertex

Joe Jimenez Former CEO, Novartis

Patrick Soon-Shiong, MD CEO, NantWorks

Janet Woodcock, MD Director, FDA Center for Drug Evaluation and Research (CDER)

Marc Tessier-Lavigne, PhD President, Stanford University

Maria Millan, MD President, California Institute of Regenerative Medicine

Gary Gibbons, MD Director, NHLBI

Brian Kobilka, MD 2012 Nobel Prize (Chemistry)

Howard Bauchner, MD Chief Editor, JAMA

John Keaney, MD Associate Editor, NEJM

Paula Kiberstis, PhD Senior Editor, Science

Peter Kirkpatrick, PhD Chief Editor, Nature Reviews Drug Discovery

Joseph C. Wu, MD, PhD Director, Stanford Cardiovascu-lar Institute; Simon H. Stertzer Professor of Medicine and Radiology

Kuldev Singh, MD Professor of Ophthalmology

Mark Mercola, PhD Professor of Medicine (Cardiology)

Sanjay Malhotra, PhD Associate Professor (Research) of Radiation Oncology

Chaitan Khosla, PhD Wells H. Rauser and Harold M. Petiprin Professor in the School of Engineering and Professor of Chemistry

Katy Claiborn, PhD Senior Researcher/Writer

Organizing Committee

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ANNIVERSARY CELEBRATION

50th

Monday, January 22, 2018

8 a.m. - 5 p.m.

Li Ka Shing Center for

Learning and Knowledge:

Paul Berg Hall

Registration:

https://tinyurl.com/Shumway50

Department ofCardiothoracic SurgeryM E D I C I N E

of Dr. Norman E. Shumway’sFirst Heart Transplant

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Stanford-China Cardiovascular Research Symposium

The 2017 Stanford-China Cardiovascular Symposium took place on September 21-22 in the Li Ka Shing Center on the Stanford School of Medicine Campus. The event, sponsored in part by the Stanford Cardiovascular Institute and the Chi-Li Pao Foundation, brought together over 300 attendees, including: over 60 visitors from China, faculty, postdocs, graduate student members of the Stanford community, and representatives of the bio-technology industry.

The symposium featured 50 world-class speakers, including Nobel Laureate Dr. Brian Ko-bilka, the President of the National Academy of Medicine Dr. Victor Dzau, and pioneering researchers from the top cardiovascular hospitals in China. The presentations spanned vast fields, from the basic molecular mechanisms that contribute to the development of heart disease to imaging techniques used to visualize heart function, and the surgical interven-tions used to treat heart defects. In addition, the speakers described the rapid and exciting development in cardiovascular medicine and research in China, where a high volume of car-diac procedures and rich resources in human genetic analysis are driving new discoveries.

A major theme of the presentations was the potential for future international collabora-tions, in which each nation can leverage the strengths of the other to promote research advances. Furthermore, the symposium served as an invaluable networking opportunity for researchers, clinicians and trainees.

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The Stanford Vascular Medicine Program was started by Drs. John Cooke and Victor Dzau who wrote with novel insight the editorial, "The time has come for vascular medicine” in the Annals of Internal Medicine in 1990. Currently, under Dr. Nicholas Leeper’s leadership, it is continuing to embrace the spirit of innovation and is composed of a full spec-trum bench-to-bedside translational vascular research and a high volume clinical practice.

Dr. Leeper’s group engages in genomic and molecular biology approaches to develop new translational targets for ath-erosclerosis and aneurysm disease and these endeavors are complemented by efforts in “Big Data” and bioinformatics, where machine learning is applied to identify new predictors of adverse outcomes for subjects with peripheral vascular diseases. Clinical research areas include early stage trials focused on novel anti-thrombotic and pro-angiogenic agents.

The Stanford Vascular Medicine Fellowship Program will resume July 2018 after several years of absence following the NHLBI K12 programs. This one-year non-interventional program aims to produce experts in arterial, venous and lymphatic diseases, including related conditions of atherothrombosis, aneurysm disease, and inflammatory vascular disorders. The curriculum will cover risk factor management, as well as advanced training related to wound care, imaging, and preventative and interventional therapeutic approaches. Rotations will include specialties such as vascular surgery, cardiology, endocrinology, hematology, rheumatology, neurology and vascular radiology.

Interested individuals who have completed an Internal Medicine residency (with or without advanced cardiology, hematology or rheumatol-ogy training) and seek comprehensive vascular training should contact Eri Fukaya MD, PhD (efukaya@stanford.edu) for more information.

Stanford Vascular Medicine is part of the Division of Vascular Surgery: https://vascular.stanford.edu/ Examples of ongoing vascular research opportunities: http://med.stanford.edu/leeperlab.html

Eri Fukaya MD, PhD

New Fellowship Opportunity in Vascular Medicine

The American Heart Association Scientific Sessions were held November 11-15 in Anaheim, California. Many members of the Stanford Cardiovascular Institute attended to share their work and hear from leading experts in the field. In addition, multiple CVI members were honored with awards recognizing their contributions to basic, clinical, and translational advancements in cardiovascular science.

These awards included:

Alyssa Flores | Peripheral Vascular Disease Fellows in Training Travel Award

Robert Harrington, MD | Clinical Research Prize

Ngan Huang, PhD | Jay D. Coffman Young Investigator Award

Ioannis Karakikes, PhD / Joseph Wu, MD, PhD | Best Manuscript Award in Circulation Research

Marlene Rabinovitch, MD | Distinguished Scientist Lecturer

Paul Wang, MD | Clinical Cardiology Council Distinguished Achievement Award

Joseph Wu, MD, PhD | George E. Brown Memorial Lecture; AHA Merit Award

Sean Wu, MD, PhD | Superior Editorial Consultant for Circulation Research

Mingtao Zhao, PhD | Finalist, Louis N. and Arnold M. Katz Basic Research Prize

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'Humanized' Mice Inadequate for Stem Cell Transplantation Studies

In 1959, when the School of Medicine relocated from San Francisco to a new complex on the university campus, a gallon of gas was 25 cents, Alaska became the 49th state, and Barbie hit toy stores.

Designed by Edward Durell Stone, the complex integrated outdoor and in-terior landscapes, with pierced grills, walls of glass bricks and a network of courtyards. But the buildings that compose the complex have not kept up with the accelerating demands of today’s medicine, and while the recent addition of structural steel frames to the exterior of the Edwards building makes it seismically safe, the buildings remain functionally deficient.

The Biomedical Innovation Building is the first step in a sequence of new buildings that eventually will replace the outdated complex. It will house laboratories and support space for nearly 1,000 faculty, students and staff in specialties that include orthopedic surgery, pediatrics, im-munology and genomics.

“The BMI will bring together world-leading re-search teams in a modern and technological-ly advanced facility,” said  Lloyd Minor, MD, dean of the School of Medicine. “More than that, the BMI will foster scientific collabora-tion and encourage the formal and informal interactions that are necessary for innovation and precision health.”

The building, which is scheduled for comple-tion by 2019, will bring together multidisci-plinary teams of engineers, basic scientists

and physician-researchers from nine areas, including the Stanford Cardiovascular Institute; Sean N. Parker Center for Allergy and Asthma Research; the Stanford Initiative to Cure Hearing Loss; the Stanford Hu-man Systems Immunology Center; and the Stanford Institute for Immu-nity, Transplantation and Infection.

The building’s central concept is to foster collaboration and interaction through open lab configurations and spaces that enable occupants to gather, confer, and mingle. Each floor will include adaptable confer-ence rooms, small huddle booths and open lounge areas. An 80-seat meeting room and a large outdoor terrace will be accessible for scien-tific symposia and receptions.

A type of mouse widely used to assess how the human immune system responds to transplant-ed stem cells does not reflect what is likely to occur in patients. Known

as “humanized” mice, the animals have been engineered to have a human, rather than a murine, immune system. Researchers have relied upon the animals to study, among other things, the immune response to the transplantation of pancreatic islet cells for diabetes and skin grafts for burn victims.

However, Stanford researchers found that the humanized mice are unable to robustly reject the transplantation of genetically mis-matched human stem cells.

“In an ideal situation, these humanized mice would reject foreign stem cells just as a hu-

man patient would,” said Joseph Wu, MD, PhD, director of Stanford’s Cardiovascular Institute. “We could then test a variety of im-munosuppressive drugs to learn which might work best in patients, or screen for new drugs that could inhibit this rejection. We can’t do that with these animals.”

Wu shares senior authorship of the research, which was published Aug. 22 in Cell Reports, with Dale Greiner, PhD, professor at the Uni-versity of Massachusetts Medical School, and Leonard Shultz, PhD, professor at the Jackson Laboratory. Former postdoctoral scholars Ni-gel Kooreman, MD, and Patricia de Almeida, PhD, and graduate student Jonathan Stack, DVM, share lead authorship of the study.

To understand more about what was hap-pening, Kooreman and his colleagues created a new mouse model. Instead of re-constituting the animals’ immune systems

with human cells, they used immune and bone marrow cells from a different strain of mice. Unlike the humanized mice, these new mice robustly rejected human pluripotent stem cells as well as mouse stem cells from a genetically mismatched strain.

More research needs to be done to identify the cause of the discrepancy between the two types of animals. In the meantime, they are warning other researchers of potential pitfalls in using this model to screen for im-munosuppressive drugs that could be effec-tive after human stem cell transplants.

The research was funded by the California Institute of Regenerative Medicine (CIRM), the National Institutes of Health (NIH) and the Helmsley Charitable Trust.

http://med.stanford.edu/news/all-news/2017/08 /mouse-model-of-human-immune-system-inad-equate-for-stem-cell-studies.html

A New Home for the CVI

Nigel Kooreman, MD

http://med.stanford.edu/news/all-news/2017/10/planned-research-build-ing-designed-for-innovation-collaboration.html

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Leslie Purchase describes herself a data devotee. So, when she heard about the Project Baseline study—one of the largest, most comprehen-sive efforts to understand the basic underpinnings of health and dis-ease—she jumped at the chance to participate.

The study is an ambitious endeavor. Launched in April after years of designing and planning by Verily, an Alphabet company, in partnership with Stanford Medicine and the Duke University School of Medicine, it aims to understand the molecular basis of health by repeatedly col-lecting biomedical data from as many as 10,000 participants over the course of at least four years.

Observing how a person’s health data changes over time, regardless of whether they remain healthy or fall ill, could provide the first compre-hensive atlas of what it means to be “well”, or help researchers learn the subtle signals given off by the body at the earliest stages of cancer, heart disease or other disorders. Purchase is a particularly valuable participant in the study; as a breast cancer survivor, her biological data could provide information for researchers seeking to understand the murky border between health and disease.

“It’s important that we enroll a broad spectrum of participants, from those who are healthy to those who have a higher-than-normal risk for cancer or cardiovascular disease,” said professor and chair of radiolo-gy Sanjiv "Sam" Gambhir, MD, PhD, the study’s principal investiga-

tor at Stanford. “We also need people of all ages and ethnic backgrounds. The reason that this is so important is that we want to capture the tran-sition from health to illness at a molecular level. Enrolling people at higher risk can increase the probability that we will observe study participants transitioning to an ill state during the course of the study. And this transition may look different in dif-ferent ethnic groups or genders.”

Participation in the study involves a two-day visit to Stanford, during which participants’ health history and vital signs are assessed and bio-specimens such as saliva and blood are collected. Clinical tests such as echocardiograms, CT scans and chest X-rays are conducted, and par-ticipants are given an investigational study watch and a sleep sensor to measure their activity and sleep. After the initial visit, participants respond to regular surveys, and return to Stanford at least once a year for further data collection.

“This study is highly unique in the depth of information it gathers about individuals over time,” said Gambhir, who is also the director of the Ca-nary Center for Cancer Early Detection at Stanford. “We want to encour-age anyone interested—particularly underrepresented minorities, the elderly and those at high risk for cancer or cardiovascular disease—to visit the website to learn more about the study and apply to participate.”

Sanjiv Sam Gambhir, MD, PhD

Mechanical heart valves may be safer in certain cases than valves made of animal tissue and should be used more in heart-valve replacements, especially in younger patients, according to a study by researchers at Stanford.

The study was published Nov. 8 in The New England Journal of Medicine. Joseph Woo, MD, profes-sor and chair of cardiothoracic surgery at Stanford is the senior author.

Heart-valve disease, which can lead to heart failure and sudden death, can be present at birth or re-sult from infections, heart attacks or other heart conditions. When a valve becomes so diseased that it impedes the delivery of blood to the body, open-heart surgery to replace the valve with a new one generally is recommended.

Researchers examined rates of mortality, stroke, bleeding and reoperation in patients who under-went heart-valve surgery at 142 hospitals in California between 1996 and 2013.

Results showed a stark difference in health benefits depending on which valve was being replaced, Woo said.

“For most heart surgeons who have to face this conversation every single day, this choice is very much on our minds,” Woo said. “For many heart surgeons throughout the country and beyond, this study could have a major impact.”

Read more: http://med.stanford.edu/news/all-news/2017/11/mechanical-heart-valve-often-the-safest-choice.html

Mechanical Heart Valve Often the Safest Choice

Read more: http://med.stanford.edu/news/all-news/2017/10/project-baseline-seeks-participants-for-study-of-health-disease.html

Project Baseline Seeks Participants for Study of Biomedical Basis of Health

Joseph Woo, MD

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National and Global Cardiovascular Conferences

DECEMBER 2017 22nd World Cardiology Conference December 11-12, 2017 Rome, Italy World Cardiology

JANUARY 2018 Keystone Symposia Heart Failure: Crossing the Translational Divide January 14-18, 2018 Keystone, CO Keystone

Keystone Symposia Bioenergetics and Metabolic Disease January 21-25, 2018 Keystone, CO Keystone

World Stem Cell Summit January 22-26, 2018 Miami, FL WSCS16

AHA International Stroke Conference January 24–26, 2018 Los Angeles, CA AHA

Vascular and Endovascular Surgery Society – Annual Winter Meeting January 31-February 4, 2018 Vail, CO VESS

FEBRUARY 2018 International Stoke Conference 2018 February 24-26, 2018 Los Angeles, CA Stoke Conference

Keystone Symposia Atherosclerosis: Lessons Learned and Concepts Challenges February 4-7, 2018 Taos, NM Keystone

Keystone Symposia Vascular Biology and Human Diseases: From Molecular Pathways to Novel Therapeutics February 25-March 1, 2018 Santa Fe, NM Keystone

MARCH 2018 American College of Cardiology Scientific Session & Expo March 10-12, 2018 Orlando, FL ACC Scientific Session

Society for Clinical Vascular Surgery Annual Symposium March 17-21, 2018 Las Vegas, NV SCVS

Epidemiology and Prevention: Lifestyle and Cardiometabolic Health March 20-23, 2018 New Orleans, LA EPI LIFESTYLE 2017

APRIL 2018 AHA QCOR April 6–7, 2018 Arlington, VA AHA

MAY 2018 AHA ATVB|PVD May 10–12, 2018 San Francisco, CA AHA

JULY 2018 AHA BCVS July 30–August 2, 2018 San Antonio, TX AHA

SEPTEMBER 2018 AHA Council on Hypertension September 6–9 Chicago, IL AHA

Stenting Better than Medication Alone Early on in Heart Disease, Study Finds

For many patients with stable heart disease who would normally be treated with medication alone, inserting a vessel-opening stent into narrowed heart vessels could be a better treatment option, according to a multi-cen-ter study published in Circulation.

In the study, which followed patients who received either medication alone or stents, those who had the stents insert-ed early on were found to have significantly less chest pain and fewer urgent hospitalizations.

In addition, while stenting was more expensive up front, after three years the costs evened out. This was primarily due to the reduced need for hospitalizations and urgent stenting procedures in those who received early stents, said William Fearon, MD, professor of cardiovascular medicine at Stanford and lead author of the study. About 50 percent of those who received medication alone eventually needed emergency stenting, he said.

Fearon’s studies have focused on the use of fractional flow reserve technology to help determine when it’s appropriate to insert stents and in which vessels. The study showed that by using this technique, it’s possible to identify the patients with stable heart disease who would benefit from a stent, rather than solely taking medications.

http://scopeblog.stanford.edu/2017/11/02/stenting-better-than-medication-alone-early-on-in-heart-disease-study-finds/

William Fearon, MD

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Seed Grant Winners

Each year the CVI awards seed grants to fund innovative cardiovascular re-search projects. This year, winners were selected from over 90 applications, and the awardees proposed projects that initiate new areas of pediatric and obstetric research, the development of new technologies for heart and vascular biology, and the mechanisms of sudden cardiac death.

PI: Christopher Gardner, PhD Co-Investigators: Michael P. Snyder, MD; Francois Haddad, MD Addressing the obesity and Diabetes epidemic through understanding personalized energy expenditure. This

study funded by CHRI.

PI: Doff Bryan McElhinney, MD Psychosocial, Cognitive, and Quality of Life Outcomes in Children and Adults with Repaired Tetralogy of Fallot with Pulmonary Atresia and Major Aortopulmonary Collateral Arteries. This

study funded by CHRI.

PI: James Priest, MD Co-Investigator: Mads Melbye, MD, DMSc A Sensitized Genetic Association Study for Congenital Heart Disease. This study

funded by CHRI

PI: Oscar Abilez, MD, PhD Co-PIs: Huxiao Yang, PhD.; Hung-Ta Wo, MD Early Detection of Arrhythmogenesis due to Cardiac Fibrosis via Correlation of In Vitro Modeling and Clinical Assessment This study funded by the Gootter Foundation

PI: Fatima Rodriguez, MD, MPH Co-Investigator: Rajesh Dash, MD, PhD Bridging the Gap: The Impact of a New Virtual Preventive Cardiology Clinic on Cardiovascular Risk Reduction in Two High Risk Ethnic Populations

PI: Sarah Heilshorn, PhD Co-Investigator: Joseph Woo, MD Stem Cell-derived Exosomes as Potential Therapy for Acute Myocardial Infarction

PI: Laura Lazzeroni, PhD Co-Investigator: Thomas Quertermous, MD Integrating MultiOmic Data in Coronary Heart Disease: A Pilot Study for New Statistical Methods

PI: Koen Nieman, MD, PhD Co-Investigators: Jennifer Tremmel, MD; Dominik Fleischmann, MD Computed Tomography Guided Revascularization of Chronic Coronary Occlusions

PI: Jayakumar Rajadas, PhD Co-Investigator: Rongli Liao, PhD Study of Aggregation Mechanism of Ig Light Chains from Light Chain Amyloidosis Patients

PI: Sean Wu, MD, PhD Co-PI: Marlene Rabinovitch, MD A Perfusion Bioreactor for Understanding Endocardial-Myocardial Interactions in Hypoplastic Left Heart Syndrome

PI: Tara Chang, MD Harnessing Big Data to Reduce Peripheral Artery Disease-Related Leg Amputation in Chronic Kidney Disease

PI: Kiran Khush, MD Co-PI: Ash Alizadeh, MD, PhD A Genomic Approach for Early Noninvasive Detection of Post- Transplant Malignancies

c v i . s ta n fo rd .e d u | 10

Helen Blau, PhDAHA | Alterations in Mechanosensing and

Telomere Homeostasis impact progression of Dilated Cardiomyopathy

Sarah Heilshorn, PhDNIH | Engineered Protein Hydrogels to

Modulate Adipose-derived Stromal Cell Secretome and Exosomes for Injectable

Myocardial Infarction Therapy

Hongjie Dai, PhDNIH Director’s Pioneer Award

| Human Infrared Vision at Molecular and Cellular Scale

Patricia Nguyen, MDNIH | Multimodality Molecular Imaging of Stem Cell Therapy for Ischemic Cardiomyopathy

Euan Ashley, MDPromoted to

Professor of Medicine (Cardiovascular Medicine)

and Genetics

Karim Sallam, MDAppointed to

Clinical Assistant Professor

Philip Yang, MDBioCardia, Inc | Randomized Controlled

Pivotal Trial of Autologous Bone Marrow Mononuclear Cells Using the CardiAMP

Cell Therapy system in Patients with Post Myocardial Infarction Heart Failure

(CardiAMP Heart Failure Trial)

Recent Accomplishments

Randall Stafford on New Blood Pressure GuidelinesA panel of the nation’s leading heart experts issued new blood pressure guidelines Nov. 13 that redefine what consti-tutes high blood pressure.

High blood pressure has been redefined as reading of 130 over 80, down from 140 over 90, said Randall Stafford, MD, PhD, professor of medicine and director of the Program on Prevention Outcomes and Practices at Stanford. He was one of the 21 experts who worked on developing the new guidelines.

Q: How many people have high blood pressure?

Stafford: It is estimated that under these new guidelines, 103 million Americans have high blood pressure, up from 72 million under the previous standard.

Nearly half of all American adults, and nearly 80 percent of those aged 65 and older, will find that they qualify for blood pressure medica-tion and will need to take steps to reduce their blood pressure.

Q: Can you discuss the various treatments for lowering high blood pressure and how these will change under the new guidelines?

Stafford: The new guidelines hinge on people at higher risk for future bad events — like heart attacks and strokes — being treated more intensively. This requires being more aggressive about lifestyle changes, as well as being more willing to prescribe multiple medications for blood pressure.

http://med.stanford.edu/news/all-news/2017/11/randall-stafford-on-new-blood-pressure-guidelines.html

Randall Stafford, MD, PhD

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Three times a year, the CVI grants awards to trainees to support their travel to national conferences to present their work. Congratulations to the recent winners!

September Travel Award Winners

Mingxia Gu, PhD Mentor: Marlene

Rabinovitch, MD

"High-Throughput Drug Screening of iPSC-Derived

Vascular Cells to Reverse PAH Phenotype"

AHA Scientific Sessions 2017 Anaheim, CA

Christoph Olivier, MD Mentor: Mintu

Turakhia, MD

"Site Variation and Trends for An-tithrombotic Therapy in Patients with Atrial Fibrillation after Per-

cutaneous Coronary Intervention in the VA system: Findings from

the TREAT-AF Study" AHA Scientific Sessions 2017

Anaheim, CA

Vedant Pargaonkar, PhD Mentor: Jennifer Tremmel, MD "Clinical Outcome and Long-

term Follow-up in Patients with Angina in the Absence of Obstructive Coronary Artery

Disease" AHA Scientific Sessions 2017

Anaheim, CA

Ji-Hye Jung, PhD Mentor: Phillip Yang, MD

"Exosomal miR-106a-363 Cluster from the Hypoxic Human iPSC-derived Car-diomyocytes Restore the

Autologous Ischemic Cardiomyocytes" AHA Scientific Session 2017

Anaheim, CA

Kenneth Tran, MD Mentor: Jason Lee, MD

"Complex EVAR is Associated with Higher Peri-operative

Mortality but not Late-mor-tality Compared to Infrarenal

EVAR Amongst Octogenarians" Western Vascular Society 2017

Blaine, WA

Vivek Nanda, PhD Mentor: Nicholas Leeper, MD

"Functional Regulatory Mechanism of Smooth Muscle

Cell-Restricted LMOD1 Coronary Artery Disease Locus"

AHA Scientific Sessions 2017 Anaheim, CA

Ke Yuan, PhD Mentor: Vinicio de

Jesus Perez, MD "Loss of Wnt5a Disrupts

Endothelial-Pericyte Interaction in Pulmonary

Arterial Hypertension" AHA Scientific Sessions 2017

Anaheim, CA

Martin Willemink, MD, PhD Mentor: Dominik

Fleischmann, MD "Aortomitral Calcification

Volume Predicts Mortality in Transcatheter Aortic Valve

Replacement" AHA Scientific Sessions 2017

Anaheim, CA

Daniela Zanetti, PhD Mentor: Erik Ingelsson, MD

"Birthweight and Obesity, Type 2 Diabetes and Cardiovascular Disease: Revisiting the Berker

Hypothesis using Big Data" AHA Scientific Sessions 2017

Anaheim, CA

Mingtao Zhao, MD Mentor: Joseph Wu, MD, PhD

"Cell Type-Specific Chromatin Signatures Underline Regula-tory DNA Elements in Human

Induced Pluripotent Stem Cells and Cardiac Cells"

AHA Scientific Sessions 2017 Anaheim, CA

c v i . s ta n fo rd .e d u | 12

December 5, 2017 FRANK W. SELLKE, MD

Karl E. Karlson, MD and Gloria A. Karlson Professor of Cardiothoracic Surgery, Brown Medical School and Lifespan Hospitals

December 12, 2017 JAMES K. LIAO, MD

Harold Hines Jr. Professor; Chief, Cardiology Section; Director, Physician Scientist Training Program University of Chicago, University of Chicago

January 9, 2018JENNIFER VAN EYK, PHD

Director, Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences; Director, Basic Science Research in the Women’s Heart Center; Erika J. Glazer Chair in Women’s Heart Health, Cedars Sinai

January 16, 2018ERIK INGELSSON, MD

Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Health Research and Policy (Epidemiology)Stanford

January 23, 2018JAMES F. MARTIN, MD, PHD

Professor, Vivian L. Smith Chair in Regenerative Medicine Baylor College of Medicine

January 30, 2018ALISON L. MARSDEN, PHD

Associate Professor of Pediatrics (Cardiology) and of Bioengineering and, by courtesy, of Mechanical EngineeringStanford

February 6, 2018 (1:30 p.m., Munzer Auditorium)BRIAN BLACK, PHD

Professor, Cardiovascular Research Institute, Department of Biochemistry and Biophysics, UCSF

February 13, 2018WALTER J. KOCH, PHD

William Wikoff Smith Endowed Chair in Cardiovascular Medicine; Professor and Chair, Pharmacology, Temple University

February 20, 2018KAJIMURA SHINGO, PHD

Associate Professor, Department of Cell and Tissue Biology, UCSF

March 6, 2018: The Steven M Gootter Foundation LectureMARK E. ANDERSON, MD, PHD

William Osler Professor of Medicine; Chair, Department of Medicine, Johns Hopkins University

March 13, 2018KAM W. LEONG, PHD

Samuel Y. Sheng Professor; EiC, Biomaterials; Department of Biomedical Engineering, Columbia University

March 27, 2018SARAH C. HEILSHORN, PHD

Associate Professor, Materials Science & Engineering, Stanford; Associate Editor, Science Advances, AAAS

April 10, 2018THOMAS M. VONDRISKA, PHD

Professor of Anesthesiology, Medicine and Physiology, UCLA

April 17, 2018PEIPEI PING, PHD

Professor, Physiology; Professor, Medicine/Cardiology, and Bioinformatics, UCLA; Director, NIH BD2K Center of Excellence at UCLA; Director, NIH BD2K Centers-Coordination Center at UCLA

May 1, 2018GEOFFREY PITT, MD, PHD

Director of the Cardiovascular Research Institute; The Ida and Theo Rossi Distinguished Professor of Medicine, Weill Cornell Medical College

May 8, 2018ROBERT J. GROPLER, MD

Professor of Radiology, Medicine and Biomedical EngineeringSenior Vice-Chair and Division Director Radiological Sciences &Chief, Cardiovascular Imaging LaboratoryWashington University School of Medicine

May 15, 2018BRADFORD C. BERK, MD, PHD

Distinguished University Professor in Medicine, Neurology, Pathology, and Pharmacology & PhysiologyDirector, University of Rochester Neurorestoration Institute University of Rochester Medical Center

May 22, 2018PETER LIBBY, MD

Mallinckrodt Professor of Medicine, Harvard Medical SchoolSenior Physician, Brigham and Women’s Hospital

May 29, 2018SHAOCHEN CHEN, PHD

Professor and Vice Chair of NanoEngineering Department Professor of Bioengineering and Radiology Departments; Co-Director of Biomaterials and Tissue Engineering Center, University of California, San Diego

June 5, 2018CHRISTINE MUMMERY, PHD

Professor of Developmental Biology, Chair Dept. of Anatomy & Embryology, Leiden University Medical Center

http://cvi.stanford.edu

Frontiers in Cardiovascular Science 2017-2018

Tuesdays 12:30 - 1:20 p.m. (unless otherwise noted), Li Ka Shing Center, LK130

c v i . s ta n fo rd .e d u | 13

AHA (American Heart Association)Collaborative Sciences Award Letter of Intent due: Nov 1, 2017 Application deadline: Feb 5, 2018 AHA

Institute for Precision Cardiovascular Medicine - Uncovering Patterns 1 year award, $150,000 Deadline: Nov 1, 2017 AHA

Spectrum Pilot Grants Amount of funding: $15-50K for 1 year Deadline: Anticipated to be end of 2017/early 2018 Spectrum Pilot Grants

NHLBI Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood and Sleep Disorders and Diseases (R21) Amount of funding: $275K direct costs for 2 year period; 2 year maximum Deadline: January 10, 2018 RFA-HL-17-015

Wallace H. Coulter Translation Research Grant Program Stanford CoulteR–Translational Research Grants Deadline: Feb 16, 2018 Coulter

National Institutes of Health Improving Outcomes in Cancer Treatment-Related Cardiotoxicty (R01) Deadline: Feb. 5, 2018 R01: PA-16-035

NHLBI Single-Site Investigator-Initiated Clinical Trials (R61/R33) Deadline: Feb. 13, 2018 PAR-16-405

Improving Outcomes in Cancer Treatment-Related Cardiotoxicty (R21) Deadline: Feb. 16, 2018 R21: PA-16-036

NHLBI Clinical Trial Pilot Studies (R34) Deadline: Feb. 16, 2018 PAR-16-037

Progeria Research Foundation Research Grants (Innovative, Established Investigator, Specialty awards) Deadline: March 2018 Progeria Research

Faculty Funding Opportunities

Postdoctoral Funding Opportunities

AHA Postdoctoral Fellowship Amount of funding: $51,484 - $125,120, 2yrs maximum Deadline: Nov. 2, 2017 AHA

Career Development Award Deadline: Dec 4, 2017 AHA

Cardiovascular Institute (CVI) Multi-disciplinary Training Program in Cardiovascular Imaging at Stanford T32 Training Grant Two positions available

Deadline: Aug. 15, 2018 (for a position

starting Nov. 1, 2018)

CVI T32

Howard Hughes Medical Research Institute (HHMI) Hanna H. Gray Fellows Program Postdoctoral phase: up to $60,000 for salary and a $20,000 expense allowance per year for up to 4 years (minimum of two years and a maximum of 4 years) Deadline: Jan. 10, 2018, 3 p.m. ET (via the HHMI online website) Hanna Gray

National Institutes of Health Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows Deadline: Dec. 8, 2017 PA-16-307

K99/R00 NIH Pathway to Independence Award Deadline: Feb. 12, 2018 PA-16-193

K08 Mentored Clinical Research Career Development Award Deadline: Feb. 12, 2018 PA-16-191

K23 Mentored Patient-Oriented Research Career Development Award Deadline: Feb. 12, 2018 PA-16-198

NHLBI K01 Mentored Career Development Award to Promote Faculty Diversity Deadline: Feb. 20, 2018 RFA-HL-16-006

Stanford Child Health Research Institute (CHRI) Clinical Trainee Support Deadline: Feb. 2018 CHRI Clinical Trainee

Marfan Foundation Victor A. McKusick Fellowship Program Early Investigator Grant Program Deadline: Feb. 2018 Marfan Foundation

Spectrum Education Program TL1 Clinical Research Training Program Deadline: Feb. 1, 2018 Spectrum

KL2 Mentored Career Development Program Deadline: Feb. 1, 2018 Spectrum

Thrasher Research Fund Early Career Awards Deadline: March 2018 (Concept submission) Thrasher Early Career Awards

c v i . s ta n fo rd .e d u | 14

Clinical Biomarker & Phenotyping Core Lab (BPCL)

BPCL provides quantitative assessment of clinical cardiovascular phe-notypes for translational research and clinical trials. These cardiovas-cular phenotypes include evaluating cardiac structure and function, measuring carotid intimal thickness and arterial stiffness, and testing endothelial function and cardiopulmonary exercise testing.

In collaboration with the Human Immune Monitoring Center at Stanford and members of the Cardiovascular Institute, we also offer central blood processing and banking capabili-ties. In addition, we develop new biomarker platforms and imaging modalities.

Contact: Francois Haddad, MD / fhaddad@stanford.edu

CVI Cores

Normal and patient-derived reprogrammed cardiomy-ocytes are a tremendous resource for researchers and physicians here at Stanford and around the country. Understanding the disease process directly at the pop-ulation level and observing these cells as surrogates under a myriad conditions has the potential to be a game-changer for cardiovascular medical research.

To facilitate research in a dish that allows screening of new compounds or characterization of human disease phenotypes using cardiomyocytes, the Institute created a service by which de-identified peripheral blood mononuclear cell (PBMC) samples from selected patients can be sent to Stanford CVI for reprogramming free of cost.

SCVI biobank is supported in part by National Heart, Lung and Blood Institute (NHLBI) and the Stanford Cardiovascular Institute (CVI).

Stanford iPSC Biobank was recently mentioned in Nature Methods news: nature.com/nmeth/

journal/v12/n2/full/nmeth.3263.html.

Contact: Joseph Wu, MD, PhD / joewu@stanford.edu or Biobank manager, Yan Zhuge, PhD / yanzhuge@stanford.edu with any questions

3DQ Imaging Laboratory Stanford’s 3DQ Imaging Laboratory de-velops new approaches to exploration, analysis and quantitative assessments of diagnostic images that result in new and/or more cost-effective diagnostic approach-es, and new techniques for the design and monitoring of therapy. The lab processes over 1,200 clinical cases to deliver relevant visualization and analysis of medical imag-ing data at Stanford.

The lab is co-directed by Dominik Fleis-chmann, MD, Roland Bammer, PhD and Sandy Napel, PhD.

Contact: Dominik Fleischmann, MD d.fleischmann@stanford.edu

Stanford CVI Human iPSC Biobank Service

Cardiovascular Pharma-cology (BioADD)The Cardiovascular Pharmacology/Bioma-terials and Advanced Drug Delivery (Bio-ADD) Laboratory is a cutting edge research facility that specializes in the creation of biomaterials and drug delivery agents. The lab lends its expertise toward design-ing and analyzing biomaterials, developing drug delivery devices and formulations, pharmacokinetic and pharmacodynamic studies, and developing smart materials for biomedical applications. The CVI Cardio-vascular Pharmacology also offers trainings and lectures.

Contact: Jayakumar Rajadas, PhD jayraja@stanford.edu

CVI Clinical Trials Core The CVI Clinical Trials Core provides full spectrum of support to CVI members and their clin-ical trials. The coordinators has extensive clinical research experience in both industry and academia. The team provides services and support to principal investigators and sponsors, including:

Contact: Ed Finn, Clinical Trials Manager or Hoa Ly, Clinical Research Coordinator at (650) 498-6279

• Consultation

• Study start-up management, including IRB applications, budget development

• Subject recruitment, site visits, and fol-low-ups (AE reporting and queries)

• Data management

• Regulatory compliance and documen-tation

• Closeout

c v i . s ta n fo rd .e d u | 15

Communication is at the heart of scientific advancement and innovation. This quarter, the Stanford Cardiovascular Institute members published over 350 original manuscripts and reviews, further contributing to our understanding of cardiovascular biology and disease. Here, we highlight selected manuscripts by our members.

Member Publications

OCTOBER

Passive Stretch Induces Structural and Functional Maturation of Engineered

Heart Muscle as Predicted by Computational Modeling. Abilez OJ, Tzatzalos E,

Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P,

Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Cou-

ture LA, Gold JD, Zimmermann WH, Wu JC. Stem Cells. 2017 Oct 31.

Opportunities for Improving Population-Based Management of Abdominal Aor-

tic Aneurysms. Mell MW. Circulation. 2017 Oct 31;136(18):1735-1736.

A method to quantify mechanobiologic forces during zebrafish cardiac devel-

opment using 4-D light sheet imaging and computational modeling. Vedu-

la V, Lee J, Xu H, Kuo CJ, Hsiai TK, Marsden AL. PLoS Comput Biol. 2017 Oct

30;13(10):e1005828.

Health disparities among adult patients with a phenotypic diagnosis of familial

hypercholesterolemia in the CASCADE-FH™ patient registry. Amrock SM, Duell

PB, Knickelbine T, Martin SS, O’Brien EC, Watson KE, Mitri J, Kindt I, Shrader P,

Baum SJ, Hemphill LC, Ahmed CD, Andersen RL, Kullo IJ, McCann D, Larry JA,

Murray MF, Fishberg R, Guyton JR, Wilemon K, Roe MT, Rader DJ, Ballantyne

CM, Underberg JA, Thompson P, Duffy D, Linton MF, Shapiro MD, Moriarty PM,

Knowles JW, Ahmad ZS. Atherosclerosis. 2017 Oct 6;267:19-26.

WNT-activated bone grafts repair osteonecrotic lesions in aged animals. Salmon

B, Liu B, Shen E, Chen T, Li J, Gillette M, Ransom RC, Ezran M, Johnson CA, Castillo

AB, Shen WJ, Kraemer FB, Smith AA, Helms JA. Sci Rep. 2017 Oct 27;7(1):14254.

10.1038/s41598-017-14395-9.

Polar orientation of renal grafts within the proximal seal zone affects risk of early

type Ia endoleaks after chimney endovascular aneurysm repair. Tran K, Ullery

BW, Itoga N, Lee JT. J Vasc Surg. 2017 Oct 23.

Temporary Circulatory Support in U.S. Children Awaiting Heart Transplantation.

Yarlagadda VV, Maeda K, Zhang Y, Chen S, Dykes JC, Gowen MA, Shuttleworth

P, Murray JM, Shin AY, Reinhartz O, Rosenthal DN, McElhinney DB, Almond CS.

J Am Coll Cardiol. 2017 Oct 31;70(18):2250-2260.

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell

quiescence. de Morrée A, van Velthoven CTJ, Gan Q, Salvi JS, Klein JDD, Aki-

menko I, Quarta M, Biressi S, Rando TA. Proc Natl Acad Sci USA. 2017 Oct

24;114(43):E8996-E9005.

Strategies for radiation dose reduction in nuclear cardiology and cardiac com-

puted tomography imaging: a report from the European Association of Cardio-

vascular Imaging (EACVI), the Cardiovascular Committee of European Associa-

tion of Nuclear Medicine (EANM), and the European Society of Cardiovascular

Radiology (ESCR). Gimelli A, Achenbach S, Buechel RR, Edvardsen T, Francone M,

Gaemperli O, Hacker M, Hyafil F, Kaufmann PA, Lancellotti P, Nieman K, Pontone

G, Pugliese F, Verberne HJ, Gutberlet M, Bax JJ, Neglia D; EACVI Scientific Docu-

ments Committee. Eur Heart J. 2017 Oct 20. 10.1093/eurheartj/ehx582.

Thermo-Acoustic Ultrasound for Detection of RF-Induced Device Lead Heating in

MRI. Dixit N, Stang PP, Pauly JM, Scott GC. IEEE Trans Med Imaging. 2017 Oct 17:1.

Risk of cardiovascular disease among women with endometrial cancer com-

pared to cancer-free women in the Women’s Health Initiative. Felix AS, Lehman

A, Foraker RE, Naughton MJ, Bower JK, Kuller L, Sarto GE, Stefanick ML, Van

Horn L, Jackson RD, Paskett ED. Cancer Epidemiol. 2017 Oct 16;51:62-67.

Cost-effectiveness of PCSK9 Inhibitors: Proof in the Modeling. Bonow RO, Har-rington RA, Yancy CW. JAMA Cardiol. 2017 Oct 18.

Autograft Valve-Sparing Root Replacement for Late Ross Failure during Quadru-

ple-Valve Surgery. Goldstone AB, Jensen CW, Bilbao MS, Woo YJ. Ann Thorac

Cardiovasc Surg. 2017 Oct 17.

Both Light Intensity and Moderate-to-Vigorous Physical Activity Measured by Ac-

celerometry Are Favorably Associated With Cardiometabolic Risk Factors in Old-

er Women: The Objective Physical Activity and Cardiovascular Health (OPACH)

Study. LaMonte MJ, Lewis CE, Buchner DM, Evenson KR, Rillamas-Sun E, Di C,

Lee IM, Bellettiere J, Stefanick ML, Eaton CB, Howard BV, Bird C, LaCroix AZ. J

Am Heart Assoc. 2017 Oct 17;6(10).

Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in

Human Induced Pluripotent Stem Cells and Somatic Cells. Zhao M, Shao NY, Hu S, Ma N, Srinivasan R, Jahanbani F, Lee J, Zhang SL, Snyder MP, Wu JC. Circ

Res. 2017 Oct 13.

Cangrelor compared with clopidogrel in patients with prior myocardial infarc-

tion - Insights from the CHAMPION trials. Eisen A, Harrington RA, Stone GW,

Steg PG, Gibson CM, Hamm CW, Price MJ, Prats J, Deliargyris EN, Mahaffey KW,

White HD, Bhatt DL; CHAMPION Investigators. Int J Cardiol. 2017 Oct 5.

Full Circle on Pulmonary Flow Dynamics in  Pulmonary Arterial Hyperten-

sion. Haddad F, Amsallem M. JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt

B):1278-1280.

Long-term use of Proton Pump Inhibitors, Dose-response Relationship, and As-

sociated Risk of Ischemic Stroke and Myocardial Infarction. Sehested TSG, Gerds

TA, Fosbøl EL, Hansen PW, Charlot MG, Carlson N, Hlatky MA, Torp-Pedersen C,

Gislason GH. J Intern Med. 2017 Oct 12.

Establishment of mouse expanded potential stem cells. Yang J, Ryan DJ, Wang

W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodzie-

jczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA,

Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R,

Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.

Nature. 2017 Oct 19;550(7676):393-397.

Haemodynamic profiles of children with end-stage heart failure. Chen S, Dykes

JC, McElhinney DB, Gajarski RJ, Shin AY, Hollander SA, Everitt ME, Price JF,

Thiagarajan RR, Kindel SJ, Rossano JW, Kaufman BD, May LJ, Pruitt E, Rosen-thal DN, Almond CS. Eur Heart J. 2017 Oct 7;38(38):2900-2909.

Hybrid Atrial Fibrillation Ablation: Current Status and a Look Ahead. Khoyne-

zhad A, Ellenbogen KA, Al-Atassi T, Wang PJ, Kasirajan V, Wang X, Edgerton JR.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10).

c v i . s ta n fo rd .e d u | 16

Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Car-

diotoxicity: Opportunities and Problems. Magdy T, Schuldt AJT, Wu JC, Bern-stein D, Burridge PW. Annu Rev Pharmacol Toxicol. 2017 Oct 6.

Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue re-

pair. Hu MS, Walmsley GG, Barnes LA, Weiskopf K, Rennert RC, Duscher D, Ja-

nuszyk M, Maan ZN, Hong WX, Cheung AT, Leavitt T, Marshall CD, Ransom RC,

Malhotra S, Moore AL, Rajadas J, Lorenz HP, Weissman IL, Gurtner GC, Longa-ker MT. JCI Insight. 2017 Oct 5;2(19).

Nkx2.5+ Cardiomyoblasts Contribute to Cardiomyogenesis in the Neonatal

Heart. Serpooshan V, Liu YH, Buikema JW, Galdos FX, Chirikian O, Paige S, Ven-

katraman S, Kumar A, Rawnsley DR, Huang X, Pijnappels DA, Wu SM. Sci Rep.

2017 Oct 3;7(1):12590.

Molecular mechanisms and structural features of cardiomyopathy-causing tro-

ponin T mutants in the tropomyosin overlap region. Gangadharan B, Sunitha

MS, Mukherjee S, Chowdhury RR, Haque F, Sekar N, Sowdhamini R, Spudich JA,

Mercer JA. Proc Natl Acad Sci USA. 2017 Oct 17;114(42):11115-11120.

Mechanical confinement regulates cartilage matrix formation by chondrocytes.

Lee HP, Gu L, Mooney DJ, Levenston ME, Chaudhuri O. Nat Mater. 2017 Oct 2.

Impact of Stent Size Selection on Acute and Long-Term Outcomes After

Drug-Eluting Stent Implantation in De Novo Coronary Lesions. Kitahara H, Oka-

da K, Kimura T, Yock PG, Lansky AJ, Popma JJ, Yeung AC, Fitzgerald PJ, Honda Y. Circ Cardiovasc Interv. 2017 Oct;10(10).

Impact of Tachyarrhythmia Detection Rate and Time from Detection to Shock on

Outcomes in Nationwide US Practice. Piccini JP, Sanders P, Shah R, Roberts G,

Karst E, Turakhia MP. Am J Cardiol. 2017 Oct 15;120(8):1325-1331.

In  Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b,

c-Fos, and Gata2 Overexpression within Teratoma. Tsukada M, Ota Y, Wilkinson

AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S. Stem Cell Reports. 2017 Oct

10;9(4):1024-1033.

Identification of new susceptibility loci for type 2 diabetes and shared etiologi-

cal pathways with coronary heart disease. Zhao W, Rasheed A, Tikkanen E, Lee

JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander

M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chambers JC, Chen

P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas

S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH,

Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-

Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang

JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP,

Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF,

Nordestgaard BG, Tybjaerg-Hansen A, Young R; CHD Exome+ Consortium, Benn

M, Frikke-Schmidt R, Kamstrup PR; EPIC-CVD Consortium; EPIC-Interact Con-

sortium; Michigan Biobank, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW,

Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI,

Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader

DJ, Danesh J, Voight BF, Saleheen D. Nat Genet. 2017 Oct;49(10):1450-1457.

Functional Cardiac Recovery and Hematologic Response to Chemotherapy in

Patients With Light-Chain Amyloidosis (from the Stanford University Amyloido-

sis Registry). Tuzovic M, Kobayashi Y, Wheeler M, Barrett C, Liedtke M, Lafayette R, Schrier S, Haddad F, Witteles R. Am J Cardiol. 2017 Oct 15;120(8):1381-1386

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Therapy-Breakthrough

in Low-Density Lipoprotein Cholesterol Lowering, Breakdown in Value. Mark DB,

Richman I, Hlatky MA. JAMA Cardiol. 2017 Oct 1;2(10):1066-1068.

Lineage-specific dynamic and pre-established enhancer-promoter contacts co-

operate in terminal differentiation. Rubin AJ, Barajas BC, Furlan-Magaril M, Lo-

pez-Pajares V, Mumbach MR, Howard I, Kim DS, Boxer LD, Cairns J, Spivakov M,

Wingett SW, Shi M, Zhao Z, Greenleaf WJ, Kundaje A, Snyder M, Chang HY, Fraser

P, Khavari PA. Nat Genet. 2017 Oct;49(10):1522-1528.

Cangrelor Versus Clopidogrel on a Background of Unfractionated Heparin

(from CHAMPION PHOENIX). Vaduganathan M, Harrington RA, Stone GW, Steg

PG, Gibson CM, Hamm CW, Price MJ, Deliargyris EN, Prats J, Mahaffey KW,

White HD, Bhatt DL; CHAMPION PHOENIX Investigators. Am J Cardiol. 2017 Oct

1;120(7):1043-1048.

Value of Strain Imaging and Maximal Oxygen Consumption in Patients With Hy-

pertrophic Cardiomyopathy. Moneghetti KJ, Stolfo D, Christle JW, Kobayashi

Y, Finocchiaro G, Sinagra G, Myers J, Ashley EA, Haddad F, Wheeler MT. Am J

Cardiol. 2017 Oct 1;120(7):1203-1208.

Effect of extended-duration thromboprophylaxis on venous thromboembolism

and major bleeding among acutely ill hospitalized medical patients: a bivariate

analysis. Chi G, Goldhaber SZ, Kittelson JM, Turpie AGG, Hernandez AF, Hull RD,

Gold A, Curnutte JT, Cohen AT, Harrington RA, Gibson CM. J Thromb Haemost.

2017 Oct;15(10):1913-1922.

In Vivo Rescue of the Hematopoietic Niche By Pluripotent Stem Cell Comple-

mentation of Defective Osteoblast Compartments. Chubb R, Oh J, Riley AK,

Kimura T, Wu SM, Wu JY. Stem Cells. 2017 Oct;35(10):2150-2159.

Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human

Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived Cardiomyo-

cytes. Lee WH, Chen WY, Shao NY, Xiao D, Qin X, Baker N, Bae HR, Wei TT, Wang Y,

Shukla P, Wu H, Kodo K, Ong SG, Wu JC. Stem Cells. 2017 Oct;35(10):2138-2149.

Prognostic significance of early aortic remodeling in acute uncomplicated type

B aortic dissection and intramural hematoma. Sailer AM, Nelemans PJ, Hastie

TJ, Chin AS, Huininga M, Chiu P, Fischbein MP, Dake MD, Miller DC, Schurink

GW, Fleischmann D. J Thorac Cardiovasc Surg. 2017 Oct;154(4):1192-1200.

A novel protein-engineered hepatocyte growth factor analog released via a

shear-thinning injectable hydrogel enhances post-infarction ventricular func-

tion. Steele AN, Cai L, Truong VN, Edwards BB, Goldstone AB, Eskandari A, Mitch-

ell AC, Marquardt LM, Foster AA, Cochran JR, Heilshorn SC, Woo YJ. Biotechnol

Bioeng. 2017 Oct;114(10):2379-2389.

Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians

and Whites. Koshizaka M, Lopes RD, Newby LK, Clare RM, Schulte PJ, Tricoci P,

Mahaffey KW, Ogawa H, Moliterno DJ, Giugliano RP, Huber K, James S, Har-rington RA, Alexander JH. Am J Med. 2017 Oct;130(10):1170-1176.

SEPTEMBER

Percutaneous, minimally invasive approach to implantable left ventricular as-

sist device deactivation. Kidambi S, Shudo Y, Dake MD, Woo YJ, Ha RV. J Thorac

Cardiovasc Surg. 2017 Sep 13.

c v i . s ta n fo rd .e d u | 17

Limited root repair in acute type A aortic dissection is safe but results in in-

creased risk of reoperation. Chiu P, Trojan J, Tsou S, Goldstone AB, Woo YJ, Fis-chbein MP. J Thorac Cardiovasc Surg. 2017 Sep 19.

Throwing out the good with the bad: Declining potential donor hearts with

left ventricular dysfunction. Moayedi Y, Khush KK. J Heart Lung Transplant.

2017 Sep 25.

Heart failure management with ambulatory pulmonary artery pressure moni-

toring. Sandhu AT, Heidenreich PA. Trends Cardiovasc Med. 2017 Sep 15.

Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the

PARTNER Trial. Douglas PS, Leon MB, Mack MJ, Svensson LG, Webb JG, Hahn RT,

Pibarot P, Weissman NJ, Miller DC, Kapadia S, Herrmann HC, Kodali SK, Makkar

RR, Thourani VH, Lerakis S, Lowry AM, Rajeswaran J, Finn MT, Alu MC, Smith CR,

Blackstone EH; PARTNER Trial Investigators. JAMA Cardiol. 2017 Sep 27.

Boosting the down-shifting luminescence of rare-earth nanocrystals for biolog-

ical imaging beyond 1500 nm. Zhong Y, Ma Z, Zhu S, Yue J, Zhang M, Antaris AL,

Yuan J, Cui R, Wan H, Zhou Y, Wang W, Huang NF, Luo J, Hu Z, Dai H. Nat Com-

mun. 2017 Sep 29;8(1):737.

Dynamics of the human antibody repertoire after B cell depletion in systemic

sclerosis. de Bourcy CFA, Dekker CL, Davis MM, Nicolls MR, Quake SR. Sci Immu-

nol. 2017 Sep 29;2(15).

Multiplexed genetic engineering of human hematopoietic stem and progenitor

cells using CRISPR/Cas9 and AAV6. Bak RO, Dever DP, Reinisch A, Cruz Hernan-

dez D, Majeti R, Porteus MH. Elife. 2017 Sep 28;6.

Macrophage-released ADAMTS1 promotes muscle stem cell activation. Du H,

Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ.

Nat Commun. 2017 Sep 22;8(1):669.

Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary

Arterial Hypertension. Saito T, Miyagawa K, Chen SY, Tamosiuniene R, Wang L,

Sharp O, Samayoa E, Harada D, Moonen JAJ, Cao A, Chen PI, Hennigs JK, Gu M,

Li CG, Leib RD, Li D, Adams CM, Del Rosario PA, Bill MA, Haddad F, Montoya JG,

Robinson W, Fantl WJ, Nolan GP, Zamanian RT, Nicolls MR, Chiu CY, Ariza ME,

Rabinovitch M. Circulation. 2017 Sep 21.

Load-dependent effects of apelin on murine cardiomyocytes. Peyronnet R, Bol-

lensdorff C, Capel RA, Rog-Zielinska EA, Woods CE, Charo DN, Lookin O, Fajardo

G, Ho M, Quertermous T, Ashley EA, Kohl P. Prog Biophys Mol Biol. 2017 Sep 18.

Features and Outcomes of Methamphetamine Associated Pulmonary Arteri-

al Hypertension. Zamanian RT, Hedlin H, Greuenwald P, Wilson DM, Segal JI,

Jorden M, Kudelko K, Liu J, Hsi A, Rupp A, Sweatt AJ, Tuder R, Berry GJ, Rab-inovitch M, Doyle RL, De Jesus Perez V, Kawut SM. Am J Respir Crit Care Med.

2017 Sep 21.

Chronic antepartum maternal hyperoxygenation in a case of severe fetal Eb-

stein’s anomaly with circular shunt physiology. Arunamata A, Axelrod DM, Bi-

anco K, Balasubramanian S, Quirin A, Tacy TA. Ann Pediatr Cardiol. 2017 Sep-

Dec;10(3):284-287.

Myocardial bridging is associated with exercise-induced ventricular arrhythmia

and increases in QT dispersion. Nishikii-Tachibana M, Pargaonkar VS, Schnittger I, Haddad F, Rogers IS, Tremmel JA, Wang PJ. Ann Noninvasive Electrocardiol.

2017 Sep 18.

A method for determining exercise oscillatory ventilation in heart failure: Prog-

nostic value and practical implications. Vainshelboim B, Amin A, Christle JW,

Hebbal S, Ashley EA, Myers J. Int J Cardiol. 2017 Sep 14.

CRY2 interactions for optical control of intracellular signaling. Duan L, Hope J,

Ong Q, Lou HY, Kim N, McCarthy C, Acero V, Lin MZ, Cui B. Nat Commun. 2017

Sep 15;8(1):547.

Endothelial APLNR regulates tissue fatty acid uptake and is essential for ape-

lin’s glucose-lowering effects. Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma

B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL,

Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Sci Transl

Med. 2017 Sep 13;9(407).

Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific

Mortality: The Women’s Health Initiative Randomized Trials. Manson JE, Aragaki

AK, Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Chlebowski RT, Howard

BV, Thomson CA, Margolis KL, Lewis CE, Stefanick ML, Jackson RD, Johnson KC,

Martin LW, Shumaker SA, Espeland MA, Wactawski-Wende J; WHI Investigators.

JAMA. 2017 Sep 12;318(10):927-938.

Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolim-

us) for pulmonary arterial hypertension. Spiekerkoetter E, Sung YK, Sudheen-

dra D, Scott V, Del Rosario P, Bill M, Haddad F, Long-Boyle J, Hedlin H, Zamanian RT. Eur Respir J. 2017 Sep 11;50(3).

Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Mac-

rophage Development. Phanstiel DH, Van Bortle K, Spacek D, Hess GT, Sham-

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c v i . s ta n fo rd .e d u | 21

Leadership

Joseph C. Wu, MD, PhDDirector, Stanford Cardiovascular Institute Simon H. Stertzer Professor of Medicine (Cardiovascular) and Radiology

Robert A. Harrington, MDArthur L. Bloomfield Professor of Medicine Chair, Dept. of Medicine

Stephen J. Roth, MD, MPHProfessor and Chief, Pediatric CardiologyDirector, Children’s Heart Center

Ronald L. Dalman, MDWalter C. and Elsa R. Chidester Professor of SurgeryChief, Division of Vascular Surgery

Michael Snyder, PhDStanford W. Ascherman Professor and Chair, Dept. of GeneticsDirector, Stanford Center for Genomics and Personalized Medicine

Dominik Fleischmann, MDProfessor, Dept. of RadiologyChief, Cardiovascular Imaging

Y. Joseph Woo, MDNorman E. Shumway Professor in Cardiothoracic SurgeryChair, Dept. of Cardiothoracic Surgery

Kenneth Mahaffey, MDProfessor, Dept. of MedicineVice Chair of Medicinefor Clinical Research

Alan Yeung, MDLi Ka Shing Professor of MedicineCo-Chief (Clinical), Division of Cardiovascular Medicine

Mark Nicolls, MDProfessor of Pulmonary and Critical Care Medicine, Dept. of Medicine, Chief, Pulmonary and Critical Care Medicine

Paul Yock, MDMartha Meier Weiland Professor, Bioengineering and Medicine; and Professor, by courtesy, of Mechanical Engineering,Director, Byers Center for Biodesign

Tom Quertermous, MDWilliam G. Irwin Professor of MedicineCo-Chief (Research), Division of Cardiovascular Medicine

Marlene Rabinovitch, MDDwight and Vera Dunlevie Professor in Pediatric Cardiology

c v i . s ta n fo rd .e d u | 22

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