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Stanford Radiology LPCH
Fast Pediatric MRI
Shreyas Vasanawala, MD/PhD
Stanford University
Lucile Packard Children’s Hospital
2013 Par Lab Celebration
How fast computation is changing our clinical practice
Stanford Radiology LPCH
Stanford Radiology LPCH
Current Solution
INVASIVE
LIMITS
ACCESS
Stanford Radiology LPCH
Stanford Radiology LPCH
Why is MRI lengthy?
• Complex protocols with multiple sets of
images in multiple planes
• Encoding spatial information takes time
Stanford Radiology LPCH
MRI Sampling Concept
Fourier
transform
Fourier (k)-space Image space
Stanford Radiology LPCH
Stanford Radiology LPCH
Ringl et. al.,
Radiology
Nov. 2007
8:1 compression ratio
visually indistinguishable
Stanford Radiology LPCH
Opportunity: Images are compressible.
Why spend time trying to collect information that is not there?
Compressed Sensing
Stanford Radiology LPCH
Concept
Fourier
transform
k-space Image space
Stanford Radiology LPCH
Teleradiology approach: First collect, then compress
Compression
101000110100 1101011 Compression
Stanford Radiology LPCH
Compressed Sensing
Instead: Sample less, then reconstruct.
Donoho
IEEE TIF ‘06
Candes et al.
IEEE TIF ’06
101000110100 1101011 Compression
Courtesy M. Lustig
Stanford Radiology LPCH
No CS CS
Miki
Lustig
2 fold
speedup, i.e.
15 second
breath-hold vs
usual 30 seconds
Stanford Radiology LPCH
Barrier to clinical use
Image reconstruction time
Stanford Radiology LPCH
Use enabled by Fast Image
Reconstruction ( < 1 minute)
Mark Murphy Kurt Keutzer
Stanford Radiology LPCH
No CS CS
Stanford Radiology LPCH
5 year old male No CS CS
7.2 x
speed
Stanford Radiology LPCH
Since
Last
Year:
Free-
breathing
MRI
Stanford Radiology LPCH
Stanford Radiology LPCH
Resolve cardiac motion
Joseph
Cheng
Michael
Lustig
Tao
Zhang
Stanford Radiology LPCH
Exam goals:
Heart anatomy
Heart Chamber volumes
Chamber wall motion
Quantification of blood flow
Stanford Radiology LPCH
Single 4D scan
Real-time stereoscopic
rendering/navigation of data
8 minute scan gives
same information as
conventional 90 minute
scan
Stanford Radiology LPCH
L1-SPIRIT ARC/GRAPPA
MP
R
Vo
lum
e-r
en
deri
ng
> 1 day reconstruction time
reduced to under 20 minutes as a
result of ParLab innovation
Stanford Radiology LPCH
Stanford Radiology LPCH
Stanford Radiology LPCH
Could go even faster
Stanford Radiology LPCH
Thank you Par Lab
Briefer, lighter, safer anesthesia
for pediatric MRI