fatty liver (steatosis) definition: it is the accumulation of excessive amount of lipids more than...
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Fatty liver (Steatosis)
Definition:
It is the accumulation of excessive amount of lipids more than 4% of the weight of the liver leading to liver cells replacement by fibrous tissues with subsequent liver cirrhosis.
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Causes of Fatty liver
1.Over feeding of fats.
2.Over feeding of carbohydrates.
3.Over mobilization of F.A from depot to liver.
4.Decreased oxidation of F.A. due to:
A. Deficiency of pantothenic acid.
B. Deficiency of carnitine.
C. Increased NADH/NAD ratio as in alcoholism.
5. Decreased mobilization of fats from liver to blood.
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Definition:
These are factors which facilitate transport of TAG
from liver to be utilized by the tissues. These factors
may be either:
1. Substances needed for phospholipid biosynthesis.
2. Substances needed for protein biosynthesis.
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1. Substances needed for phospholipid biosynthesis.
A. Essential F.A.
B. Inositol.
C. Choline
D. Substances needed for choline biosynthesis as
Methionine,Glycine betaine,Folic acid and Vit.B12
2. Substances needed for protein biosynthesis:
A. Protein of high biological value.
B. Essential a.a (e.g Methionine).
C. Non-essential a.a (Serine).
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Antilipotropic Factors
Definition:
These are substances which inhibit mobilization of fats from the liver.
Causes:
1. Substances Which inhibit phospholipid biosynthesis.
2. Substances Which inhibit protein biosynthesis.
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1. Substances Which inhibit phospholipid biosynthesis as in over feeding of cholesterol, niacin and biotine.
2. Substances Which inhibit protein biosynthesis like carbon tetracholoride, choloroform, phosphorus, arsenic and ethionine