The mission of FUJIFILM Cellular Dynamics, Inc. (FCDI)

is to provide access to biologically relevant and predictive

human biology. Toward this end, FCDI has pioneered

the industrial manufacture of induced pluripotent stem

(iPS) cells, which are derived from non-embryonic human

tissue cells (e.g. skin, blood) and have the potential

to differentiate into any cell type in the human body,

including heart, muscle, and brain. Importantly, iPS cells

and the cells differentiated from them can be generated

from any individual or cohort of individuals representing

specific genetic profiles or disease states. These cells

retain the donor’s unique genetic profile, including any

disease-associated mutations or polymorphisms. FCDI’s

human cells are rapidly being adopted for use in disease

research, drug development, and preclinical studies

aimed at developing cell-based therapeutics for human

genetic and degenerative disease.

p True Human Biology in a Dish iPS cell technology provides unprecedented access to personalized human biology, enabling powerful new strategies for disease research, drug development, and cell-based therapeutics.

“Footprint-free” iPS Cells

Differentiated Cells(brain, heart, liver...)

Applications(disease modeling,

drug screening, regenerative medicine...)

Donor Sample(e.g. blood, skin)

General PopulationGenetic diversityDisease phenotypesVariable drug responses

Human Cells. Endless Possibilities from Discovery to Regenerative Medicine.

FCDI: Providing True Biology in a DishHuman^

Human cells: Cells are differentiated from human iPS cells and exhibit expected characteristics and functions.

Homogenous and reproducible: Cells are highly pure, providing biologically relevant and reproducible results.

Acute and long-term testing: Cells remain viable and pure in culture for weeks, enabling assessment of both acute and sub-chronic responses.

Easy to implement: Cells are shipped cryopreserved and usually with cell culture media formulated for optimal cell performance. Simply thaw and use.

Peer reviewed: Pharmaceutical, biotechnology, and academic scientists have published 40+ articles on how FCDI products enable their research. Visit the FCDI website for the most current list of articles.

Advantages

Products

Since its inception in 2004, FCDI has developed and launched a suite of products that

include iPS cell-derived differentiated cells representing “typical” human biology (iCell®

products), as well as individuals representing specific disease states (MyCell® Products).

Our iCell products include human cells of the cardiac (heart), neural (brain), hepatic

(liver), musculoskeletal (muscle, bone), and hematopoietic (blood) lineages. FCDI’s

MyCell Products enable custom iPS cell generation, genetic engineering, and

differentiation from customer-defined donor samples representing specific disease states

or genetic profiles.

FCDI’s iCell and MyCell products overcome many of the limitations of existing cell

models, including the lack of relevant human biology, low reproducibility, and lack of

availability. Because of these limitations, FCDI’s products are rapidly being adopted

by researchers in government and academic research institutes, biopharmaceutical

companies, and non-profit disease foundations. In the last 2 - 3 years, FCDI’s iPS cell-

derived products have been cited in over 40 peer-reviewed publications in which the

cells have been used to accelerate disease research, drug discovery, and safety testing.

In addition, FCDI’s products are being used in preclinical studies toward the design,

development, and manufacture of cell-based therapeutics.

Working with FCDI

FCDI: Your Provider of iPS Cell-derived CellsFCDI’s iCell and MyCell products are shipped worldwide as vials of cryopreserved human cells, which are then

thawed, plated, and assayed in the customer’s laboratory. To ensure success, FCDI provides protocols, “how

to” videos, remote and on-site technical support, and iCertification training courses. FCDI’s differentiated cell

products have been used and published on for basic and clinical research, drug development (including high-

throughput drug screening), and safety testing.

FCDI: Your Colleague in Developing AssaysFCDI has a dedicated team of scientists and a state-of-the-art applications lab, outfitted with cell analysis

platforms commonly used in research and drug screening, for the sole purpose of developing applications and

protocols to support customers’ needs. In addition, FCDI has established relationships with many platform

providers and contract research organizations to facilitate access to the latest technology and services.

Customers are encouraged to engage in conversation with our scientists to discuss specific applications,

review data, and share insight regarding the use of iPS cell technology.

FCDI: Your Partner in Making Disease Models Widely AvailableFCDI is actively engaged in partnerships with funding organizations, disease foundations, and research

institutes to create novel, disease-relevant cell models and make them widely accessible to academic and

pharmaceutical researchers. Specifically, FCDI offers support in identifying and accessing donor samples,

guidance in experimental design, and assistance in making these resources broadly available through FCDI or

various biobanks with whom FCDI has existing relationships.

p FCDI Process for Enabling Disease Research FCDI has an established process to enable funding organizations, disease foundations, and research institutes to develop and distribute novel, disease-relevant cell models to the scientific community.

FCDI helps partners to

identify and accessdonor samples.

Identify Samples

FCDI works with partners to determine theirresearch needs.

Define Project Manufacture Cells

FCDI manufacturesiPS cells and/or differentiated cells.

Supply/Store Cells

Cells can be depositedinto biobanks for accessby the research community or made commercially available by FCDI.

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iCell Products

Provide access to biologically relevant, human iPS cells for disease modeling, drug discovery, toxicity testing, and regenerative medicine. FCDI’s rapidly growing portfolio of iCell products includes human cardiomyocytes, GABAergic, glutamatergic, dopaminergic, and motor neurons, hepatocytes, endothelial cells, astrocytes, hematopoietic progenitor cells, skeletal myoblasts, macrophages, and others.

Visit the FCDI website for the most current list of supported cell types.

DS-FCDI180907 © Copyright 2018 FUJIFILM Cellular Dynamics, Inc.

For More InformationFUJIFILM Cellular Dynamics, Inc. 525 Science Drive Madison, WI 53711 USA

(608) 310-5100 | Toll-free US (877) 310-6688 fcdi-sales@fujifilm.com www.fujifilmcdi.com

Ordering InformationVisit the FCDI website for an up-to-date list of iCell products. Have a unique requirement? Contact us.

Product1, 2 Catalog # (Viable Cells/Vial)iCell Astrocytes Kit, 01434 R1092 (≥1.0 million)

iCell Cardiac Progenitor Cells Kit, 01279 R1093 (≥5.0 million)

iCell Cardiomyocytes Kit, 01434 R1007 (≥4.0 million)

iCell Cardiomyocytes Kit, 11713 R1105 (≥1.0 million)

R1117 (3 x ≥1.0 million)

R1106 (≥4.0 million)

iCell Cardiomyocytes2 Kit, 01434 R1012 (≥4.0 million)

iCell DopaNeurons Kit, 01279 R1088 (≥1.0 million)

R1108 (3 x ≥1.0 million)

R1032 (≥5.0 million)

iCell Endothelial Cells Kit, 11713 R1112 (≥1.0 million)

iCell GABANeurons Kit, 01279 R1011 (≥4.0 million)

iCell GABANeurons Kit, 01434 R1013 (≥4.0 million)

iCell GlutaNeurons Kit, 01279 R1061 (≥1.0 million)

R1116 (3 x ≥1.0 million)

R1034 (≥6.0 million)

iCell Hematopoietic Progenitor Cells Kit, 01279 R1094 (≥1.0 million)

iCell Hepatoblasts Kit, 01434 R1096 (≥5.0 million)

iCell Hepatocytes 2.0 Kit, 01279 R1104 (≥3.0 million)

R1025 (≥10.0 million)

iCell Hepatocytes 2.0 Kit, 01434 R1027 (≥10.0 million)

iCell Macrophages Kit, 01279 R1099 (≥1.0 million)

iCell Mesenchymal Stem Cells Kit, 01279 R1098 (≥1.0 million)

iCell Motor Neurons Kit, 01279 R1051 (≥1.0 million)

R1049 (≥3.0 million)

iCell Retinal Pigment Epithelial Cells Kit, 01279 R1102 (≥1.0 million)

R1113 (3 x ≥1.0 million)

R1101 (≥5.0 million)

iCell Skeletal Myoblasts Kit, 01279 R1100 (≥8.0 million)

1 A User's Guide is provided in all iCell kits.2 Visit www.fujifilmcdi.com for details on any media supplied in a specific kit.