fecal microbiota transplantation

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Fecal Microbiota Transplantation JOHN LITTLE, SPT WHEELING JESUIT UNIVERSITY

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Page 1: Fecal Microbiota Transplantation

Fecal Microbiota Transplantation

JOHN LITTLE, SPTWHEELING JESUIT UNIVERSITY

Page 2: Fecal Microbiota Transplantation

History

▪ First documented in 4th Century China as “Yellow Soup”▪ In some countries, maternal feces is inserted into the

newborn’s mouth to “jumpstart” the colon▪ June 17th, 2013: FDA approved the procedure for

recurrent C. diff.▪ 0 documented serious side effects▪ 92% - 95% success rate

Page 3: Fecal Microbiota Transplantation

Clostridium difficile (C. diff.)

▪ 250,000 hospitalizations and 14,000 deaths per year in the US ▪ A harmful bacteria that replaces the “good”, naturally

occurring bacteria in the digestive tract▪ Can occur from several factors but most commonly from

long term antibiotics and hospital visits▪ The bacteria can live on a surface for months and is

transmitted orally▪ Symptoms include diarrhea (up to 10-15x per day),

dehydration, blood/pus in the stool, kidney failure, bowel rupture, and death▪ 20% reoccurrence

Page 4: Fecal Microbiota Transplantation

The Procedure

▪ Carefully screened donor stool is mixed with a saline solution▪ The solution is introduced into the GI tract via a NG

tube, fecal enema, oral capsules, or during a colonoscopy▪ The “good” bacteria multiply and help flush out the C.

diff. bacteria▪ 92% - 95% success rate

Page 5: Fecal Microbiota Transplantation

Are You a Candidate?

▪ General Requirements:▪ Recurrent C. Diff. (usually 3 cases)▪ 1 failed course of Vancomycin ▪ 2 or more severe cases, resulting in ICU admittance

▪ Where is this procedure performed?▪ Clinicians offering this procedure that are located closest to

Cabell Huntington Hospital include: ▪ Columbus, Ohio▪ Cleveland, Ohio▪ Indianapolis, Illinois

Page 6: Fecal Microbiota Transplantation

Price of the Procedure

▪ Most insurance policies do not cover the procedure▪ There is no fee for the actual procedure, if your

insurance will cover the colonoscopy▪ Out of pocket costs for a colonoscopy are often $3,000▪ Oral capsule administration is usually $500

Page 7: Fecal Microbiota Transplantation

References

Feltman, Rachel. "Good News: You Can Take Your Fecal Transplants Orally." The Washington Post, 11 Oct. 2014. Web. 8 July 2015. <http://www.washingtonpost.com/news/speaking-of-science/wp/2014/10/11/good-news-you-can-take-your-fecal-transplants-orally/>."The Fecal Transplant Foundation." 2015. Web. 8 July 2015. <http://thefecaltransplantfoundation.org/>.