Fertilovit® F THY

Indication - specific micronutrients for thyroid autoimmunity

Information for health care professionals

Fertilovit® F THY

Dietetic food for special medical purposes targeting 7 issues of autoimmune thyroiditis:

Exacerbation due to increased iodine supply In patients with thyroid autoimmunity, iodine excess contributes to apoptosis of thyroid tissue

(Xu et al, 2016). Therefore, affected patients benefit from a diet low in iodine (Bürgi, 2010).

Selenium Selenium contributes to normal thyroid function and can improve inflammatory activity in thyroid

autoimmunity (Gärtner et al, 2002; Fan et al, 2014).

Vitamin B12 deficiency Patients suffering from thyroid autoimmunity have an increased risk of vitamin B12 deficiency

(Ness-Abramof, 2006). Vitamin B12 has an important role in healthy function of the immune system and an adequate supply should be ensured.

Vitamin D deficiency As vitamin D has immune-modulatory and anti-inflammatory properties, it doesn’t come as a surprise

that various scientists have observed an association between vitamin D deficiency and autoimmune thyroiditis (Mazokopakis et al, 2014).

Hyperhomocysteinemia Hypothyroidism is often associated with increased homocysteine values (Morris et al, 2001). Folic acid

as well as vitamins B6 and B12 contribute to a normalized homocysteine metabolism.

Increased oxidative stress Oxidative stress seems to be involved in triggering thyroid autoimmunity (Bianchi et al, 1999; Erdamar

et al, 2008). Patients show increased levels of oxidative stress (Taddei et al, 2006) and decreased antioxidant values (Bianchi et al, 1999).

Gluten intolerance Autoimmune thyroiditis is often accompanied by coeliac disease (Freeman, 2016). Even if coeliac

disease can not be established, thyroid patients seem to benefit from a diet low in gluten (Lundin and Wijmenga, 2015).

Comprehensive therapeutic concept for thyroid autoimmunityIn addition to standard hormonal and symptomatical treatments, a comprehensive therapeutic concept also encompasses complementary measures.

Recent scientific studies have shown a significant benefit of micronutrient supplementation. Iodine-free preparations with selenium and antioxidants are recommended.

60

50

40

30

20%

Blastocyst rate

60

50

40

30

20%

Pregnancy rate

60

50

40

30

20%

Ongoing pregnancy rate

Ideal preconceptional combination for thyroid autoimmunity Autoimmune thyroiditis is considered a risk factor for early pregnancy loss (Crawford and Steiner, 2016). TSH adjustment to optimum levels and indication-specific supplementation of micronutrients are obligatory measures.

Fertilovit® F THY contains neither gluten, gelatine nor lactose.

Adequate supply of folic acid Highly dosed folic acid can decrease the risk of early

pregnancy loss (Chavarro et al, 2016) and allows for fast protection: with 800 µg folic acid daily, a protective status can be achieved within 4 weeks (Pietrzik et al, 2005). In addition to that, this dosage ensures an adequate supply for carriers of an MTHFR polymorphism (Thaler, 2014).

Improved response Coenzyme Q10 can improve ovarian response and

mitochondrial function in mature patients (Burstein et al, 2009).

Decreased risk of early pregnancy loss Indication-specific supplementation can significantly

increase blastocyst rate and clinical pregnancy rate following IVF/ICSI (Wogatzky et al, 2013).

Special features • 800 µg folic acid with an indication-adjusted preconceptional

vitamin and mineral supply • Iodine-free • 100 µg selenium • Vitamin C with sustained release • Patent lodged • Free from gluten, lactose and gelatine • Suitable for vegans

Indications • Hashimoto • Grave’s disease • Female fertility patient with thyroid autoimmunity

Dosage1 capsule daily

At a glance:

■ without supplementation■ Fertilovit® F THY

Study proven effectiveness (Wogatzky et al, 2013, n = 106 patients)

• Less L-thyroxine needed during treatment (p < 0.01)

• Improved blastocyst rate (p < 0.01)

• Increase of ongoing pregnancy rate (p < 0.05)

* Nutrient reference values according to regulation 1169/2011/EU

Daily dose (1 capsule) % NRV*

Vitamin C 100 mg 125Vitamin E 15 mg 125Vitamin B1 4 mg 364Vitamin B2 4,5 mg 321Pantothenic acid 18 mg 300Vitamin B6 5,4 mg 386Vitamin B12 9 µg 360Folic acid 800 µg 400Vitamin D 5 µg 100Niacin 17 mg 106Biotin 180 µg 360Zinc 2,25 mg 23Magnesium 100 mg 26Iron 7,5 mg 54Selenium 100 µg 181Coenzyme Q10 20 mg –

Nutrition facts:

References Bentov et al. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril 2010; 93:272–5 | Bianchi et al. Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: effect of treatment. Horm Metab Res. 1999; 31(11):620-4 | Brannon PM. Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc. 2012; 71(2):205-12 | Bürgi H. Iodine excess. Best pract Res Clin Endocrinol Metab 2010; 24(1): 107 - 115 | Burstein et al. Co-enzyme Q10 supplementation improves ovarian response and mitochondrial function in aged mice. Fertil Steril 2009; 92(3):31 | Chavarro et al. Contributions of the Nurses‘ Health Studies to Reproductive Health Research. Am J Public Health. 2016; 106(9):1669-76 | Crawford und Steiner. Thyroid Autoimmunity and Reproductive Function. Semin Reprod Med. 2016; 34(6):343-350 | Dror DK. Vitamin D status during pregnancy: maternal, fetal and postnatal outcomes. Curr Opin Obstet Gynecol 2011; 23(6):422-426 | Ebisch IMW. Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple, Hum. Reprod. 2006; 21(7):1725-1733 | Erdamar et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008; 46(7):1004-10 | Fan et al. Selenium supplementation for autoimmune thyroiditis: a systematic review and meta-analysis. Int J Endocrinol 2014; 2014:904573 | Franchini. Hemostatic changes in thyroid diseases: haemostasis and thrombosis. Hematology. 2006; 11(3):203-8 | Freeman HJ. Endocrine manifestations in celiac disease. World J Gastroenterol 2016; 22:8472-9.91 | Gärtner et al. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab. 2002; 87(4):1687-91 | Goh YI et al. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006; 28(8):680-9 | Lundin KE, Wijmenga C. Coeliac disease and autoimmune disease - genetic overlap and screening. Nat Rev Gastroenterol Hepatol 2015; 12:507-15 | Mazokopakis und Kotsiris. Hashimoto‘s autoimmune thyroiditis and vitamin D deciency. Current aspects. Hell J Nucl Med 2014; 17:37-40 | Morris et al. Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey. Atherosclerosis. 2001; 155:195–200 | Ness- Abramof R, et al. Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease. Am J Med Sci 2006; 332:119-122 | Pietrzik et al.: Randomized, placebo-controlled, double-blind study evaluating the effectiveness of a folic acid containing multivitamin supplement in increasing erythrocyte folate levels in young women of child-bearing age. Ann of Nutr & Metab 2005; 6.7.29:368 | Taddei et al. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto‘s thyroiditis. J Clin Endocrinol Metab. 2006; 91(12):5076-82 | Thaler CJ. Folate Metabolism and Human Reproduction Geburtshilfe Frauenheilkd. 2014; 74(9):845-851 | Wogatzky J et al. Dietary Supplementation Improves Blastocyst Number and Ongoing Pregnancy Rate of IVF Patients with Hashimoto Thyroiditis. J Food Nutr Disor 2013; 2:4 | Xu et al. Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease. J Autoimmun 2016; 75:50-57

Controlled Quality Fertilovit® F THY is manufactured according to ISO 22000 and GMP (good manufacturing practice) standards in the European Union. Quality is regularly tested by independent laboratories. Fertilovit® F THY is free from lactose, gluten, gelatine, and GMOs.

To learn more, please visit:

Gonadosan Distribution GmbHRömerstrasse 2

6900 BregenzAustria

www.fertilovit.com

For free samples for your patients, kindly contact us:

office@fertilovit.com or +43 5574 54195

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