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Page 1: Fig. S1

Fig. S1

Supplement

Page 2: Fig. S1

Fig. S2

APOBEC3Z1 10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z1b MEASAAPMARCLMPEDTFTENFNNVVWQKATYLCYEVELPDGDYRVPPGQDKDFLHNQGGHMAG--PPRHAEMRFLDLISSWNLDQDLCYRVTCFISWSPCA--VCAQRLAEFLRENSHV equine A3Z1a ..........Y..D........K..N.PRK.............S.....W..G..R.KVT..P.--...D............K...K.R.............--D......G........ human A3A ....P.SGP.H..DPHI..S....GIGRHK........RL.NGTS.KMD.HRG.....AKNLLCGFYG....L.....VP.LQ..PAQI....W.......FSWG..GEVRA..Q..T.. 130 140 150 160 170 180 190 200 210 220 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|.... equine A3Z1b SLRIFASRIYTKRKYGDYREGLRTLKEAGAQIAIMTSKEFEHCWKTFVDNQGRTFQAWDELDAESRYWSMELQRILQPTAPPSLPPLYFPPSHPVPGPSFRSLRGSSG* equine A3Z1a .........F..---...KA.....QA.E......A.E......E....H...P..P.....PK...L.EQ..H.............C..........Y.....D...* human A3A R.....A...DYDPL--.K.A.QM.RD....VS...YD..K...D....H..CP..P..G..EH.QAL.GR.RA...NQGN*

APOBEC3Z2 10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z2a-Z2b --------MEKLDPETFSFHFLNMEFVYDRNCSYLCYQVEGRLSGSPVLSEQGVFPNEVCGKTRRHAELCFLDWFRGRLSPD-EYYCVTWFISWSPCSNCAREVAEFLKRHRNVELSIFA equine A3Z2c-Z2d --------....................G................................D.GG.......H........H-...R..................K............L. human A3F MKPHFRNTV.RMYRD...YN.Y.RPILSR..TVW...E.KTKGPSR.R.DAK-I.RGQ.YSQPEH...M...S..C.NQL.AYKCFQI...V..T..PD.VAKL....AE.P..T.T.S. 130 140 150 160 170 180 190 200 210 220 230 240 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z2a-Z2b ARLYY--CRDHEQGLQSLCNRGAQLAVMLRKDFTYCWDNFVHNSGREFSPWENIDANSDLLARKLEDLLKNPMEKLHRKTFSFHFRNLKFAKGRKCSYLCYRVEGRLSGPPGLSEQGVFL equine A3Z2c-Z2d .....--........R....S..E..I.VFR..R.......YHH..H.I.......................L....PN......C..E..YD..Y.....Q.......S.......... human A3F .....YWE..YRRA.CR.SQA..RVKI.DDEE.A...E...YSE.QP.M..YKF.D.YAF.H.T.KEI.R....AMYPHI.Y...K..RK.Y..NE.W..FTM.VVKHHS.VSWKR...R 250 260 270 280 290 300 310 320 330 340 350 360 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z2a-Z2b NEVCDENCRHAELCFLHWFRG-RLSPHADYRVTWFISWSPCSNCARQVAEFLKRHRNVELHIFAARLYYWQRN--KPGLRNLRSSGAQLAIMFFWDFRDCWDNFVHNSGRHFIPWKKINV equine A3Z2c-Z2d .....................-....DEY.H...............E.............S............--..D....C..........YQ...Y...........E.S..E.... human A3F .Q.DP.THC...R...S..CDDI...NTN.E...YT.....PE..GE.....A..S..N.T..T.....FWDTDYQE...S.SQE..SVE..GYK..KY..E...Y.DDEP.K...GLKY 370 ....|....|....| equine A3Z2a-Z2b NSRLLATKLEDLLK* equine A3Z2c-Z2d ..........EI..* human A3F .FLF.DS..QEI.E*

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10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z2e --------MEKLDAEVFSFHFLNMEFVYDRNCSYLCYQVEGRLSGSPVLSEQGVFPNEVCGKTRRHAELCFLDWFRG-RLSPDEYYCVTWFISWSPCSNCAREVAEFLKRHRNVELSIFA human A3C MNPQIRNP.KAMYPGT.Y.Q.K.LWEAN...ETW..FT...IKRR.V.SWKT...R.Q.DSE.HC...R...S..CDDI...NTK.Q...YT.....PD..G......A..S..N.T..T 130 140 150 160 170 180 190 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|. equine A3Z2e ARLYYCRD--HEQGLQSLCNRGAQLAVMLRRDFTYCWDNFVHNSGREFSPWENIDANSDLLARKLEDLLK* human A3C .....FQYPCYQE..R..SQE.VAVEI.DYE..K...E...Y.DNEP.K..KGLKT.FR..K.R.RES.Q*

APOBEC3Z3 10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| equine A3Z3 MDPQAPTQRGGLGQAYQGGDYVQAPGNGNTQHLLSEDVFKKQFGNQRRVTKPYYRRKTYVCYQLKLLRGPTIAKGYFRNKKKRHAEIRFIDKINSLGLDQDQSYEITCYVTWSPCATCAC equine A3Z3v1 ........................................................................................................................ human A3H ------------------------------MA..TAET.RL..N.K..LRR...P..ALL....TPQN.S.PTR...E....C....C..NE.K.M...ET.C.QV...L.....SS..W 130 140 150 160 170 180 190 200 210 220 230 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|. equine A3Z3 KLIKFTRKFPNLSLRIFVSRLYYHWFRQNQQGLRQLWASSIPVVVMGYQEFADCWENFADNRG----NPFQSWEKLTEYSKGIKRRLQKILEQPLNLNGLEDAMGNLKLGSVDLG* equine A3Z3v1 ...............................................................----.........................-......................* human A3H E.VD.IKAHDH.N.G..A.......CKPQ.K...L.CG.QV..E...FP.........V.HEKPLSF..YKML.E.DKN.RA.....ER.KQS*

Supplement

Page 3: Fig. S1

Fig. S3

Supplement

10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2a-Z2b MEKLDPETFSFHFLNMEFVYDRNCSYLCYQVEGRLSGSPVLSEQGVFPNEVCGKTRRHAELCFLDWFRGRLSPDEYYCVTWFISWSPCSNCAREVAEFLKRHRNVELSIFAARLYYCRDH EcA3F1 ........................................................................................................................ 130 140 150 160 170 180 190 200 210 220 230 240 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2a-Z2b EQGLQSLCNRGAQLAVMLRKDFTYCWDNFVHNSGREFSPWENIDANSDLLARKLEDLLKNPMEKLHRKTFSFHFRNLKFAKGRKCSYLCYRVEGRLSGPPGLSEQGVFLNEVCDENCRHA EcA3F1 ........................................................................................................................ 250 260 270 280 290 300 310 320 330 340 350 360 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2a-Z2b ELCFLHWFRGRLSPHADYRVTWFISWSPCSNCARQVAEFLKRHRNVELHIFAARLYYWQRNKPGLRNLRSSGAQLAIMFFWDFRDCWDNFVHNSGRHFIPWKKINVNSRLLATKLEDLLK EcA3F1 .....D........................................................L......................................................... 10 20 30 40 50 60 70 80 90 100 110 120 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2c-Z2d MEKLDPETFSFHFLNMEFVYGRNCSYLCYQVEGRLSGSPVLSEQGVFPNEVCGDTGGHAELCFLHWFRGRLSPHEYYRVTWFISWSPCSNCAREVAKFLKRHRNVELSILAARLYYCRDH EcA3F2 .......................................G.......V........................................................................ 130 140 150 160 170 180 190 200 210 220 230 240 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2c-Z2d EQGLRSLCNSGAELAIMVFRDFRYCWDNFVYHHGRHFIPWENIDANSDLLARKLEDLLKNPLEKLHPNTFSFHFCNLEFAYDRKYSYLCYQVEGRLSGSPGLSEQGVFLNEVCDENCRHA EcA3F2 ........................................................................................................................ 250 260 270 280 290 300 310 320 330 340 350 360 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| eqA3Z2c-Z2d ELCFLHWFRGRLSPDEYYHVTWFISWSPCSNCAREVAEFLKRHRNVELSIFAARLYYWQRNKPDLRNLCSSGAQLAIMFYQDFRYCWDNFVHNSGREFSPWEKINVNSRLLATKLEEILK EcA3F2 ..................................................................................................I..............N......


Supplemental Fig. S1. Orange- and yellow-flowered cultivars of calendula used in this study

Fig. S1 Figure S1. Multiple alignment of the selected OSC sequences from Barbarea vulgaris and Arabidopsis thaliana, using the software Muscle; this alignment

Tholen et al ., Sup . Fig. S1

Supplemental Methods Fig. S1. WGCNA gene dendrogram

Fig S1 Figure S1: 5T4 expression in B cell development. Adapted from microarray data published online by van Zelm et al

RESEARCHARTICLE CoordinatingRoleofRXRαinDownregulating ... · Wefirst constructed aprior knowledgenetwork (PKN) comprising IL-6signaltransduction anddownstreamgeneregulation(S1 Fig)

Supplemental Figure S1 - TheranosticsSupplemental Figure Legends Fig. S1: Characterization of the cfDNA cohort and its relationship to public methylation datasets. A) Bar chart depicting

Supplemental Figure Legends Fig. S1 · Supplemental Figure Legends . Fig. S1. A: Representative polyacrylamide gel showing cleavage of 5 µM DPRSFL-ACPP by several enzymes known to

Supporting Information Figs S1–S8, Tables S1–S4 2 3 Fig. S1 · 1 1 Supporting Information Figs S1–S8, Tables S1–S4 2 3 Fig. S1 4 5 Fig. S1 Phenotypes of wild type and wp1

S1 Supporting Information: Search terms for … · Web viewS13 Fig: Funnel Plot of Adjusted Estimates of Depressive Symptom Scales and Incident Type 2 Diabetes21 S1 Supporting Information:

Supplementary Fig. S1: Banana cv. Rasthali somatic embryos

Supplementary Information (ESI): Fig. S1 Table S1 SVEC) L · Fig. S1 (a) The matrix effects of elements. L‐SVEC standard solution doped with Na (diamonds), Mg (squares) and Al (triangles)

Fig. S1 Overview of small RNA sequencing data

PRISMA 2009 Flow Diagramcambridge.org:…  · Web viewAnxiety disorders. Supplementary Fig. S1. PRISMA 2009 Flow Diagram Supplementary Table S1. Anxiety disorder studies. Authors

Figure S1 Enod11 Mtc27 MtGshs cDNA gDNA S. meliloti DPI --++ - + + - Supporting Information Fig. S1. Validation of the selected biological conditions for

SaaS UMG 509-PRO - messungelectricalengineering.com · UMG 509-PRO Device overview and technical data Fig.: Example current measurement S1 S2 L1 L2 L3 N PE 1 S2 S1 S2 S1 S2 Last K2

S1 Fig. Hydrolysis of α2-3-linked sialic by high amounts ...nizetlab.ucsd.edu/Publications/Neu5GC-Cholera-Suppl.pdf · S1 Fig. Hydrolysis of α2-3-linked sialic by high amounts of

SUPPLEMENTAL DATA - FIG S1-3dm5migu4zj3pb.cloudfront.net/manuscripts/63000/63924/JCI63924sd.pdf · SUPPLEMENTAL DATA Figure S1. Characterization of Vhl-/-mice. (A) Left panel shows

Cambridge University Presscambridge... · Web viewS1. Melting curves and standard curves of reference and target genes. Fig. S1 A. Melting curve & standard curve of ALP Fig. S1 B

Supplementary Fig. S1

Fig. S1: Hourly temperature (˚C) and broadband sound

Fig S1:Determination of population sub-structure

Dierks Supplementary Fig. S1 - Cancer Research...Dierks Supplementary Fig. S1 ITK SYK PH K402R E42K R29C TH wt K402R (kinase deficient) E42K R29C (reduced phospholipid binding) E42K

Supporting Information - Royal Society of Chemistry2 / 9 Figure Legends and Video Captios Fig. S1 1H NMR spectra of NLC. Fig. S2 1H NMR spectra of NDC. Table S1 Gelation behaviors,

Supplementary Fig. S1 Supplementary Figure S1. The co-expression profile among ALDH activity, mem Grp78 and Glut3 in SAS Sphere cells and cisplatin-resistant

Control #A A5 2 wk p.i. Brain Spleen A2 12 wk p.i. Sakuma et al., Supplementary Fig. S1 Fig. S1 Immunostaining of brain and spleen sections with goat anti-gp70/gp30

Supplementary Material for - Sciencescience.sciencemag.org/content/suppl/2015/03/04/science... · 2015. 3. 4. · Supplementary Text . Fig. S1 to S14 . Table S1 . Full Reference List

Resistance to PD1 blockade in the absence of ... · Fig. S1 Fig. S1. Validation of the LAG3NC conditional knock-in mouse. (A) LAG3 D4 domain, connecting peptide and transmembrane

Supplemental material Fig. S1. Further glucosinolates Those coded

Suppl. Fig. S1 Suppl. Fig. S1 The nucleotide sequence and its deduced amino acid sequences of CaSAMDC. The full-length of CaSAMDC (GenBank Accession No

Fig. S1. Profiles of Water contact angle (WCA) on smooth ... · Fig. S1. Profiles of Water contact angle (WCA) on smooth PDMS film (a) and smooth PFTS film (b), and diiodomethane

Supplementary Fig. S1

Fig. S1 TGA curves (DTA and weight loss) for blends of PVC

Fig. S1. Heatmap of R^2, a pairwise measure of genetic linkage … · 2017. 7. 3. · Fig. S1. Heatmap of R^2, a pairwise measure of genetic linkage between sites For pairs of biallelic

Fig S1 120414 - CSHL P