figure 1. mechanism of migration of leucocytes from peripheral blood into inflamed tissues
DESCRIPTION
Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues. Rolling. Activation. Adhesion. CD11a/CD18. Transmigration. CD11b/CD18. Selectins. Chemokines:. ICAM-1. Chemotaxins:. MCP-1. C5a. chemokines. Figure 2. - PowerPoint PPT PresentationTRANSCRIPT
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Figure 1. Mechanism of migration of leucocytes from
peripheral blood into inflamed tissues.
SelectinsICAM-1
CD11a/CD18 CD11b/CD18
Chemokines:
MCP-1 Chemotaxins: C5a
chemokines
RollingActivation
Adhesion
Transmigration
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Figure 2.Northern blot showing glomerular expression of MCP-1 mRNA correlated with monocyte infiltration
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Figure 3. Schematic diagram showing regulation of the
effects of IL‑1.
IL-1 Rt I
IL-1 Rt II
Soluble IL-1 Rt II
signal transduction
IL-1ra
IL-1ra
IL-1
IL-1
IL-1
IL-1 IL-1
Biological effects of IL‑1 are tightly regulated, in part by its endogenous receptor antagonist (IL‑1ra), as well as by expression of IL‑1 type II receptor (IL‑1RtII). IL‑1RtII (68 kD) binds to IL‑1 with high affinity (lower affinity for IL‑1 and IL‑1ra) without signal transduction. The extracellular domain of IL‑1RtII can also be released as a soluble receptor selective for IL‑1b. Hence, IL‑1RtII is also know as a decoy receptor that may reduce the effect of IL‑1.
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Figure 4.Northern blot showing synthesis of IL-1 decoy receptor in the glomeruli of IL-4 treated rats
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Figure 5. Effect of IL-4 on glomerular macrophages (M)
all M activated M
0
2
4
6
8
Control
IL-4
Cel
ls/ g
lom
eru
lar
sect
ion
(gs
) p=0.02
p=0.002
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Figure 6. Blocking TNF- prevented crescentic glomerulonephritis
Control sTNFR0
10
20
30
40
50C
resc
ents
(%
)
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Figure 7. Delayed treatment with rolipramreduces urinary TNF-
vehicle rolipram0
100
200
300
400
500U
rin
ary
TN
F-
(p
g/1
7h)
p = 0.05
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Figure 8. Delayed treatment with rolipram reduces glomerular crescents
vehicle rolipram0
10
20
30
40
Cre
scen
ts(q
uad
ran
ts/5
0 g
s)
p < 0.05
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Figure 9. Short term treatment (day 0-7) with IL-4reduction of renal injury at day 28
Control IL-40
25
50
75
100
Cre
scen
ts (
%)
p<0.01
Control IL-40
1
2
3
4
Tu
bu
lar
dam
age
sco
re
p<0.01
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Figure 10. IL-11 inactivated glomerular macrophages
Activated M
Control IL-110.0
0.5
1.0
1.5
2.0 *P<0.05
ED
-3+
M/
gcs
All M
Control IL-110
10
20
30
40
50 NS
ED
-1+
M/
gs