figure 2: trends in currently prescribed antiretroviral therapy
DESCRIPTION
Trends in ART use, HIV viral load, and CD4 count at death among HIV-infected persons in care in the US, 2000-2008 Althoff KN, et al, for the North American AIDS Cohort Collaboration on Research and Design. Figure 2: Trends in currently prescribed antiretroviral therapy - PowerPoint PPT PresentationTRANSCRIPT
2000
2001
2002
2003
2004
2005
2006
2007
2008
0 10 20 30 40 50 60 70 80 90 100
23
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15
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NNRTI-based PI-based PI & NNRTI NRTI only Any new agent Treatment naïve ART Off ART
Off HAART
Proportion of NA-ACCORD participants
N=23,941
N=20,064
N=17,154
N=24,958
N=23,752
N=23,168
N=23,024
N=21,996
N=20,678
N=18,971
Figure 2: Trends in currently prescribed antiretroviral therapy% prescribed HAART increased from 74% to 83%
Trends in ART use, HIV viral load, and CD4 count at death among HIV-infected persons in care in the US, 2000-2008
Althoff KN, et al, for the North American AIDS Cohort Collaboration on Research and Design
Trends in ART use, HIV viral load, and CD4 count at death among HIV-infected persons in care in the US, 2000-2008
Althoff KN, et al, for the North American AIDS Cohort Collaboration on Research and Design
2000 2001 2002 2003 2004 2005 2006 2007 20082
2.2
2.4
2.6
2.8
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3.2
3.4
3.6
3.8
4
0
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46 46 47 4954
58 6165
72
Overall suppressed HIV RNA Missing HIV RNA measurement Overall median HIV RNA Prescribed HAART median HIV RNA Overall mean HIV RNA Prescribed HAART mean HIV RNA
Log1
0 H
IV R
NA
Per
cent
age
N=17,154N=18,971N=20,678 N=21,996N=23,024 N=23,168 N=23,752 N=24,958N=23,941
Figure 3: Trends in the proportion with suppressed (≤2.7 log10 or ≤500 copies/mL) HIV VL and mid-year HIV VL, by antiretroviral therapy status
% suppressed increased from 46% to 72%, regardless of treatment
Trends in ART use, HIV viral load, and CD4 count at death among HIV-infected persons in care in the US, 2000-2008
Althoff KN, et al, for the North American AIDS Cohort Collaboration on Research and Design
Figure 4: Median CD4 count within 18 months prior to death (N=4,417 decedents)
Median CD4 count tripled to 209 cells/mm3
1999 2000 2001 2002 2003 2004 2005 2006 2007 20080
50
100
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Med
ian
CD
4 co
unt
at d
eath
(c
ells
/mm
3)
All N=320 N=446 N=486 N=577 N=622 N=532 N=520 N=505 N=409<50yo 75% 75% 77% 64% 64% 57% 60% 47% 47%
Trends in ART use, HIV viral load, and CD4 count at death among HIV-infected persons in care in the US, 2000-2008
Althoff KN, et al, for the North American AIDS Cohort Collaboration on Research and Design
Figure 1: Unadjusted percentages of PLWH-US within 50 states and the District of Columbia, that were alive and in care among US clinical cohorts participating in the NA-ACCORD, (N=23,884), by state, year-end 2008
% of NA-ACCORD participants among the unadjusted estimate of PLWH-US in all 50 states and DC at the end of 2008 was 3.1% (26,030/831,578)