final testimony - oversight.house.gov

Testimony of Scott Faber

on

Examining the Public Health Risks of Carcinogens in Consumer Products

Before the

Economic and Consumer Policy Subcommittee

of the

House Committee on Oversight and Government Reform

March 12, 2019 Thank you for the opportunity to testify. My name is Scott Faber, and I am the Senior Vice

President for Government Affairs for the Environmental Working Group, a national

environmental health organization that has been evaluating the safety of consumer products for

more than two decades.

Chemicals and contaminants linked to cancer can be found in food, water and many other

everyday products. However, no category of consumer products is subject to less government

oversight than cosmetics and other personal care products. Although many of the chemicals and

contaminants in cosmetics likely pose little risk, exposure to some chemicals and contaminants

used in cosmetics and other personal care products has been linked to serious health problems,

including cancer. Since 2009, 595 cosmetics manufacturers have reported using 88 chemicals

that have been linked to cancer, birth defects, or reproductive harm in more than 73,000

products.1

Chemicals and contaminants found in cosmetics and other personal care products that have been

1 Cal. Dep’t of Pub. Health, Cal. Safe Cosmetics Program, Current Data Summary, https://www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/SummaryData.aspx (last accessed Mar. 8, 2019). The California Safe Cosmetics Act of 2005 requires cosmetic manufacturers to disclose to the California Department of Public Health all products containing ingredients known or suspected to cause cancer, birth defects or other reproductive toxicity as determined by certain authoritative scientific bodies, including the Environmental Protection Agency, the National Toxicology Program and the International Agency for Research on Cancer.

linked to chronic health problems include phthalates,2 parabens,3 formaldehyde,4 chemicals

designed to release formaldehyde,5 and 1,4-dioxane.6 A full list is attached to my testimony.

Repeated use of everyday products containing these and other chemicals and contaminants

increases the risk of cancer and other serious health problems.

Nevertheless, only two pages of the 829-page Federal Food, Drug and Cosmetics Act govern

cosmetics, and those provisions provide the Food and Drug Administration no financial

resources and sharply limit the FDA’s authority to regulate chemicals and contaminants that pose

chronic risks.7 Although Congress has since given FDA the power to ensure that food additives,8

color additives9 and pesticides10 pose “no harm” from repeat exposures, Congress has not given

FDA the same authority to regulate the chronic risks posed by chemicals and contaminants in

cosmetics.

Instead, FDA largely relies upon self-regulation to address the risks posed by the $86 billion

personal care products industry. As FDA Commissioner Scott Gottlieb and Center for Food

Safety and Applied Nutrition Director Susan Mayne said last week:

“[C]urrent law does not require cosmetics to be reviewed and approved by the FDA prior

to being sold to American consumers . . . [W]hen it comes to cosmetics, companies and

individuals who market these products in the U.S. hold the responsibility for the safety

and labeling of their products. This means that ultimately a cosmetic manufacturer can

2 See Comm. on the Health Risks of Phthalates, Nat’l Research Council of the Nat’l Acad., Phthalates & Cumulative Risk Assessment: The Tasks Ahead (2008), http://www.nap.edu/catalog/12528.html. 3 See European Comm’n Sci. Comm. on Consumer Safety, Opinion on Parabens, Doc. No. SCCS/1348/10 (Dec. 2010, revised Mar. 2011), http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_041.pdf. 4 See Nat’l Toxicology Program, Report on Carcinogens (14th ed. 2016), https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf. 5 See DeGroot, Anton, et al. (2009). Formaldehyde-Releasers in Cosmetics: Relationship to Formaldehyde Contact Allergy. Contact Dermatitis, 61(2), 63-85. http://www.ncbi.nlm.nih.gov/pubmed/19706047 6 See U.S. Envtl. Prot. Agency, IRIS Toxicological Review of 1-4 Dioxane (Final Report) (2010), https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=205170. 7 Section 601(a) of the FDCA (21 U.S.C. § 361(a)) states that a cosmetic is deemed adulterated if it “bears or contains any poisonous or deleterious substance which may render it injurious to users under the conditions of use prescribed in the labeling thereof, or under such conditions of use as are customary or usual.” A cosmetic is also adulterated under the 1938 FDCA if packed in unsanitary conditions that may render it “injurious to health” or its container is composed in whole or part of any poisonous or deleterious substance that may render it “injurious to health.” 8 Food Additives Amendment of 1958, Pub. L. No. 85-929, 72 Stat. 1784. 9 Color Additives Amendment of 1960, Pub. L. No. 86-618, 74 Stat. 397. 10 Food Quality Protection Act of 1996, Pub. L. No. 104-170, 110 Stat. 1489.

decide if they’d like to test their product for safety . . . To be clear, there are currently no

legal requirements for any cosmetic manufacturer marketing products to American

consumers to test their products for safety.”11

However, industry self-regulation lacks the safeguards provided by FDA reviews. Programs like

the Cosmetics Ingredient Review (CIR), which is financed by cosmetics manufacturers and

housed inside the industry’s trade association, focus on short-term effects, such as allergic

reactions, and face significant data gaps about chemical use and toxicity. Many CIR findings are

inconsistent with the findings by other regulatory authorities or experts.12

As a result, cosmetics and other personal care products have fallen into a regulatory black hole.

To date, FDA has regulated only nine ingredients for safety reasons.13 By contrast, more than 40

nations have taken steps to ban or restrict more than 1,400 chemicals or contaminants in

cosmetics and personal care products, including chemicals linked to cancer, reproductive harm

and neurological harm. Other nations have banned long-chain parabens like isopropylparaben

and isobutylparaben, banned phthalates like dibutyl phthalate and diethylhexyl phthalate,14 and

restricted the presence of chemicals like formaldehyde15 and perfluorooctanoic acid (PFOA).16

In addition to the risks posed by intentionally added ingredients, cosmetics can be contaminated

with heavy metals, including arsenic, cadmium, lead, mercury and nickel. Though banned in

11 Statement from FDA Commissioner Scott Gottlieb, M.D., and Susan Mayne, Ph.D., director of the Center for Food Safety and Applied Nutrition, on tests confirming a 2017 finding of asbestos contamination in certain cosmetic products and new steps that FDA is pursuing to improve cosmetics safety (Mar. 5, 2019), https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm632736.htm. 12 For example, methylisothiazolinone,

iodopropynyl butylcarbamate,

and methyldibromo glutaronitrile are

preservatives deemed too risky for certain uses by other authorities but were found safe for use at higher concentrations or without similar restrictions by CIR. For a more detailed discussion, visit https://www.help.senate.gov/imo/media/doc/Faber.pdf. 13 U.S. Food & Drug Admin., Cosmetics, Prohibited & Restricted Ingredients, https://www.fda.gov/Cosmetics/GuidanceRegulation/LawsRegulations/ucm127406.htm (last accessed Mar. 7, 2019). 14 Eur. Comm’n, Annex II: List of Substances Prohibited in Cosmetic Products (last update: 24/04/2018), http://ec.europa.eu/growth/tools-databases/cosing/pdf/COSING_Annex%20II_v2.pdf (last accessed Mar. 8, 2019). 15 Eur. Comm’n, Annex III: List of Substances Which Cosmetic Products Must Not Contain Except Subject to the Restrictions Laid Down (last update: 24/10/2018), http://ec.europa.eu/growth/tools-databases/cosing/pdf/COSING_Annex%20III_v2.pdf (last accessed Mar. 8, 2019); Eur. Comm’n, Annex V: List of Preservatives Allowed in Cosmetic Products (last update: 23/11/2018), http://ec.europa.eu/growth/tools-databases/cosing/pdf/COSING_Annex%20V_v2.pdf (last accessed Mar. 8, 2019). 16 Eur. Chemicals Agency, Annex XVII to REACH – Conditions of Restriction: Entry 68 Perfluorooctanoic Acid (PFOA), https://www.echa.europa.eu/documents/10162/7a04b630-e00a-a9c5-bc85-0de793f6643c (last accessed Mar. 8, 2019).

more than 50 nations, asbestos can also contaminate cosmetics made with talc,17 such as facial

powders. Although there is no formal estimate of the number of cosmetics products that contain

talc,18 EWG found more than 2,100 products that contain talc as an ingredient in our database of

more than 26,000 personal care products. Of these, about 1,200 are loose or pressed powders that

could pose a risk of being inhaled.19

Product Form Products with Talc

Liquids, Soaps and other Solids 927

Loose Powder 123

Pressed Powder 1,051

Aerosol Spray 18

Total with Talc 2,119

Total Products in Skin Deep® 26,143

Source: Environmental Working Group’s Skin Deep® Cosmetics Database

Even small amounts of asbestos in talc can cause mesothelioma and other diseases many years

after exposure. Personal care products which have a detectable amount of asbestos are

considered adulterated by FDA, but cosmetics companies that use talc as an ingredient have no

duty to test for asbestos and detection methods cannot guarantee that talc is “asbestos-free.” FDA

encourages companies to select talc mines to avoid asbestos contamination and to conduct

testing, but companies are not obligated to share test results or safety records.

In general, FDA has very little authority to oversee the personal care products industry. Personal

care products companies do not have to register with FDA, provide FDA ingredient statements,

adopt Good Manufacturing Practices, or GMPs, report adverse events to FDA, or provide FDA

access to safety records. FDA does not have the power to suspend registration or order recalls

17 Geologically, talc and asbestos can be formed from the same parent rock. As a result, mined talc deposits in many parts of the world can be contaminated with asbestos fibers. 18 Cosmetics companies are not required to register and provide ingredient statements to FDA, so FDA is unable to estimate the number products which contain talc. 19 Envtl. Working Grp., EWG’s Skin Deep® Cosmetics Database, https://www.ewg.org/skindeep/.

when products pose the risk of serious adverse health consequences or death. By contrast,

manufacturers of food, drugs and medical devices must register with FDA, maintain and give

FDA access to records, and report adverse events. If food, drugs or devices are unsafe, FDA can

suspend production and product licenses. If unsafe food or devices reach the market, FDA can

order a recall and take legal action against drug makers that do not recall their products.20

Since the early 1950s, efforts by Congress to modernize cosmetics law have been defeated by the

cosmetics industry.21 Since 2015, however, many cosmetics companies have supported giving

FDA the authority and resources to review and regulate chemicals and contaminants of concern

in cosmetics, and have supported requiring manufacturers to register, provide ingredient

statements, adopt GMPs and report adverse events. Companies have also supported giving FDA

the power to suspend production of dangerous of products and order mandatory recalls.22

The cosmetics industry has grown dramatically since Congress enacted current cosmetics law

almost 80 years ago – from $1 billion in sales in 1938 to more than $80 billion in 2016.23 But

20 E.g., 21 U.S.C. § 350(d) (food); 21 C.F.R. § 807 (devices); 21 U.S.C. § 360 (drugs); 21 C.F.R. §§ 607.65, 1271 (biologics). 21 In October 1951, the House of Representatives authorized a Select Committee, led by then-Rep. James Delaney (D-N.Y.) to investigate the use of chemicals, compounds and synthetics in the production of cosmetics and related health effects. See H.R. Rep. No. 82-2182. More than a dozen bills to reform cosmetics have been introduced since then. See, e.g., the Cosmetics Safety Act, S. 683, 93rd Cong. (1st Sess. 1973); H.R. 1527, 93rd Cong. (1st Sess. 1973) (requiring that cosmetics containing mercury or any of its compounds bear labeling stating that fact); H.R. 14805, 93rd Cong. (1st Sess. 1974) (authorizing FDA to halt the sales and distribution of food, drugs, and cosmetics adulterated or misbranded in a manner that presents an imminent hazard to the public health); H.R. 6249, 94th Cong. (1st Sess. 1975) (applying the provisions of the FDCA to hair dyes); the Cosmetics Safety Amendments of 1975, S. 1681, 94th Cong. (2nd Sess. 1976); Cosmetics Act, H.R. 1993, 95th Cong. (1st Sess. 1977); Cosmetics Safety Amendments, S. 2365, 95th Cong. (1st Sess. 1977); Food, Drug, and Cosmetics Amendments of 1980, H.R. 2554, 91st Cong. (1st Sess. 1980) (permitting the inspection of a consulting laboratory in which food, drugs, devices, or cosmetics are being processed, packed, or held); the Safe Cosmetics Act of 2010, H.R. 5786, 111th Cong. (2nd Sess. 2010); the Safe Cosmetics Act of 2011, H.R. 2359, 112th Cong. (1st Sess. 2011); Cosmetics Safety Enhancement Act of 2012, H.R. 4262, 112th Cong. (2nd Sess. 2012); Cosmetics Safety Amendments of 2012, H.R. 4395, 112th Cong. (2nd Sess. 2012); Safe Cosmetics and Personal Care Products Act of 2013, H.R. 1385, 113th Cong. (1st Sess. 2013); Personal Care Products Safety Act, S. 1014, 114th Cong. (1st Sess. 2015); Cosmetics Modernization Amendments of 2015, H.R. 4075, 114th Cong. (1st Sess. 2015); Cosmetics Modernization Amendments of 2017, Personal Care Products Safety Act, S. 1113, 115th Cong. (1st Sess. 2017); Personal Care Products Safety Act, S. 726, 116th Cong. (1st Sess. 2019). 22 The following companies support bipartisan cosmetics reform legislation: Amyris (Biossance), Au Naturale, Babo Botanicals, Beautycounter, California Baby, Coalition of Handcrafted Entrepreneurs, Cote, Earth Mama Organics, Éclair Naturals, Estee Lauder Companies, EO Products, Goddess Garden Organics, Handcrafted Soap & Cosmetic Guild, Handmade Cosmetic Alliance, Herban Lifestyle, the Honest Company, Johnson & Johnson, Juice Beauty, L’Oreal, Made Of, Makes 3 Organics, Milk + Honey, MyChelle Dermaceuticals, OSEA, Peet Rivko, Procter & Gamble, Rahua, Revlon, Seventh Generation, Silk Therapeutics, SkinOwl, S.W. Basics, Tenoverten, Unilever, Vapour Organic Beauty. 23 Statista, Statistics & Facts on the U.S. Cosmetics and Makeup Industry, https://www.statista.com/topics/1008/cosmetics-industry/ (last accessed Mar. 8, 2019).

cosmetics law has not kept pace. Today consumers use a wide variety of personal care products.

Each day American women use an average of 12 personal care products that contain 168 different

chemicals. Men use an average of six personal care products that contain 85 different chemicals.

Most consumers believe that these chemicals are already reviewed by the FDA, and three-fourths

of consumers support strict regulation, regardless of party affiliation.24 Reforms like those

proposed by Chairman Frank Pallone25 and by Sens. Dianne Feinstein and Susan Collins26 will

ensure that these consumer expectations are being met.

Thank you for the opportunity to testify.

24 Mark Mellman & Linda DiVall, Findings From a National Survey of Likely 2016 General Election Voters (Feb. 2016), https://cdn.ewg.org/sites/default/files/u381/cosmetics.pdf?_ga=1.55566627.92668946.1470953450. 25 Press Release, House Comm. on Energy and Commerce, Pallone & Lance Unveil Bipartisan Proposal to Strengthen Cosmetic Product Regulation (Sept. 14, 2016), https://energycommerce.house.gov/newsroom/press-releases/pallone-lance-unveil-bipartisan-proposal-to-strengthen-cosmetic-product (retrieved on Mar. 8, 2019). 26 S. 726, The Personal Care Products Safety Act of 2019, available at https://www.congress.gov/bill/116th-congress/senate-bill/726/text?q=%7B%22search%22%3A%5B%22s.+726%22%5D%7D&r=1&s=1.

Scott E. Faber

Senior Vice President, Environmental Working Group.

Scott Faber is the Senior Vice President of Government Affairs for the Environmental Working Group. Prior to joining EWG in 2012, Faber served as Vice President for Federal Affairs for the Grocery Manufacturers Association, where he led efforts to enact the Food Safety Modernization Act. Previously, Faber was a campaign manager for the Environmental Defense Fund. Faber holds a J.D. from the Georgetown University Law Center, where he is an Adjunct Professor of Law.

CALIFORNIA DEPARTMENT OF PUBLIC HEALTH OCCUPATIONAL HEALTH BRANCH

CALIFORNIA SAFE COSMETICS PROGRAM June 2018

REPORTABLE INGREDIENTS LIST

The California Safe Cosmetics Act of 2005 requires cosmetic manufacturers to disclose to the California Department of Public Health (CDPH) all products containing ingredients known or suspected to cause cancer, birth defects, or other reproductive toxicity as determined by the authoritative scientific bodies cited in California Health and Safety Code Section 111791.5. These bodies are 1) the California Office of Environmental Health Hazard Assessment (Proposition 65 List of Chemicals Known to Cause Cancer or Reproductive Toxicity); 2) U.S. Environmental Protection Agency (U.S. EPA); 3) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) (formerly Center for the Evaluation of Risks to Human Reproduction (CERHR)); 4) NTP’s Report on Carcinogens (RoC); and 5) the International Agency for Research on Cancer (IARC).

To assist companies with reporting, CDPH has compiled this list of reportable ingredients based on lists and reports available from these organizations. Please note that the authoritative bodies are continually updating published information. For the most up-to-date guidance on reportable chemicals, please refer directly to the lists and reports available from these organizations.

Chemical Abstract Service (CAS) Registry Numbers and synonyms are provided for some of the listed chemicals. However, this guidance document is not all-inclusive. Manufacturers may still be required to report a chemical to CDPH even if a specific synonym or CAS number for an ingredient is not listed here.

Note to consumers: Not all of these chemicals are found in cosmetic products. Also, note that the likelihood of a cosmetic product leading to cancer or reproductive harm depends on many factors, including but not limited to the amount and type of exposure to chemicals in the product. The chemicals are listed here because of findings from research on the chemicals and not on cosmetic products.

For more information on the California Safe Cosmetics Program, please visit our webpage at: www.cdph.ca.gov/Cosmetics or call us at (877) 325-3223.

Reportable Ingredients List California Safe Cosmetics Program Introduction

Type of Toxicity Authoritative Body Listing

Chemical Synonyms CAS No.

Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

1 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Semustine 13909-09-6 x x

2 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) 13010-47-4 x x x

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) 13010-47-4 x x

3 1,1,1,2-Tetrachloroethane 630-20-6 x x x x 4 1,1,2,2-Tetrachloroethane 79-34-5 x x x x

5 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) 72-55-9 x x x

6 1,1-Dichloroethane 75-34-3 x x x 7 1,1-Dimethylhydrazine (UDMH) 57-14-7 x x x x 8 1,2,3-Trichloropropane 96-18-4 x x x x 9 1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x x

1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x 10 1,2-Dichloropropane 78-87-5 x x x 11 1,2-Diethylhydrazine 1615-80-1 x x x 12 1,2-Dimethylhydrazine 540-73-8 x x x 13 1,2-Epoxybutane 106-88-7 x x 14 1,3-Butadiene 106-99-0 x x x

1,3-Butadiene 106-99-0 x x x x x x 15 1,3-Dichloro-2-propanol (1,3-DCP) 96-23-1 x x x 16 1,3-Dichloropropene 542-75-6 x x x 17 1,3-Dinitropyrene 75321-20-9 x x x 18 1,3-Propane sultone 1120-71-4 x x x 19 1,4-Butanediol dimethanesulfonate Busulfan 55-98-1 x x x x 20 1,4-Dichloro-2-butene 764-41-0 x x 21 1,4-Dioxane 123-91-1 x x x x 22 1,6-Dinitropyrene 42397-64-8 x x x 23 1,8-Dinitropyrene 42397-65-9 x x x

24 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 555-84-0 x x x

25 1-Amino-2,4-dibromoanthraquinone 81-49-2 x x x x 26 1-Amino-2-methylanthraquinone 82-28-0 x x 27 1-Bromopropane 1-BP 106-94-5 x x x x

1-Bromopropane 1-BP 106-94-5 x x x x

Reportable Ingredients List California Safe Cosmetics Program June 2018



Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

28 1-Chloro-4-nitrobenzene 100-00-5 x x 29 1-Hydroxyanthraquinone 129-43-1 x x x 30 1-Naphthylamine 134-32-7 x x 31 1-Nitropyrene 5522-43-0 x x x 32 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 3570-75-0 x x x

33 2,2-Bis(bromomethyl)-1,3-propanediol 2,2-Bis(bromomethyl)propa ne-1,3-diol

3296-90-0 x x x

34 2,3,4,7,8-Pentachlorodibenzofuran 57117-31-4 x x 35 2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 1746-01-6 x x x

2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 1746-01-6 x x 36 2,3-Diamino-6-chloro-s -triazine (DACT) 3397-62-4 x x x

37 2,3-Dibromo-1-propanol 2,3-Dibromopropan-1-ol 96-13-9 x x x

38 2,4,5-Trimethylaniline and its strong acid salts --- x x 39 2,4,6-Trichlorophenol 88-06-2 x x x x 40 2,4.6-Trinitrotoluene (TNT) 118-96-7 x x 41 2,4-D (2,4-dichlorophenoxyacetic acid) 94-75-7 x x 42 2,4-D butyric acid 94-82-6 x x 43 2,4-Diamino-6-chloro-s-triazine (DACT) 3397-62-4 x x x 44 2,4-Diaminoanisole 615-05-4 x x x 45 2,4-Diaminoanisole sulfate 39156-41-7 x x 46 2,4-Diaminotoluene Toluene-2,4-diamine 95-80-7 x x x 47 2,4-Dinitrotoluene 121-14-2 x x x

2,4-Dinitrotoluene 121-14-2 x x x 48 2,4-Hexadienal Sorbic aldehyde 142-83-6 x x x x 49 2,5-Hexanedione 110-13-4 x x 50 2,6-Dimethyl-N-nitrosomorpholine (DMNM) 1456-28-6 x x 51 2,6-Dinitrotoluene 606-20-2 x x x

2,6-Dinitrotoluene 606-20-2 x x x 52 2,6-Xylidine (2,6-Dimethylaniline) 87-62-7 x x x 53 2-Acetylaminofluorene 53-96-3 x x 54 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 712-68-5 x x x 55 2-Aminoanthraquinone 117-79-3 x x 56 2-Aminofluorene 153-78-6 x x 57 2-Bromopropane (2-BP) 75-26-3 x x x




Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

58 2-Chloropropionic acid 598-78-7 x x 59 2-Mercaptobenzothiazole 149-30-4 x x x

60 2-Methyl-1-nitroanthraquinone (of uncertain purity) 129-15-7 x x x

61 2-Methylaziridine (Propyleneimine) 75-55-8 x x x 62 2-Methylimidazole 693-98-1 x x x 63 2-Naphthylamine 91-59-8 x x x 64 2-Nitrofluorene 607-57-8 x x x 65 2-Nitropropane 79-46-9 x x x 66 3-(N-Nitrosomethylamino) propionitrile 60153-49-3 x x x 67 3,3',4,4'-Tetrachloroazobenzene 14047-09-7 x x x x 68 3,3'-Dichloro-4,4'-diamino-diphenyl ether 28434-86-8 x x x 69 3,3'-Dichlorobenzidine 91-94-1 x x x x 70 3,3'-Dichlorobenzidine dihydrochloride 612-83-9 x x x 71 3,3'-Dimethoxybenzidine (o -Dianisidine) 119-90-4 x x x 72 3,3'-Dimethoxybenzidine dihydrochloride 20325-40-0 x x x

73 3,3'-Dimethoxybenzidine-based dyes metabolized to 3,3'-dimethoxybenzidine --- x x x

74 3,3'-Dimethylbenzidine (ortho-Tolidine) 119-93-7 x x x 75 3,3'-Dimethylbenzidine dihydrochloride 612-82-8 x x x

76 3,3'-Dimethylbenzidine-based dyes metabolized to 3,3'-dimethylbenzidine --- x x x

77 3,4,5,3’,4’-Pentachlorobiphenyl (PCB-126) 57465-28-8 x x 78 3,7-Dinitrofluoranthene 105735-71-5 x x x 79 3,9-Dinitrofluoranthene 22506-53-2 x x x 80 3-Amino-9-ethylcarbazole hydrochloride 6109-97-3 x x 81 3-Chloro-2-methylpropene 563-47-3 x x 82 3-Chloro-2-methylpropene, technical grade 563-47-3 x x 83 3-Methylcholanthrene 56-49-5 x x

84 3-Monochloropropane-1,2-diol (3-MCDP) 3-Monochloro-1,2-propanediol 96-24-2 x x x

85 3-Nitrobenzanthrone 17117-34-9 x x

86 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone 64091-91-4 x x

87 4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) 101-80-4 x x x 88 4,4'-Methylene bis(2-chloroaniline) 101-14-4 x x x x




Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

89 4,4'-Methylene bis(2-methylaniline) 838-88-0 x x x 90 4,4'-Methylene bis(N,N-dimethyl)benzenamine Michler’s base 101-61-1 x x x 91 4,4'-Methylenedianiline 101-77-9 x x x 92 4,4'-Methylenedianiline dihydrochloride 13552-44-8 x x 93 4,4'-Thiodianiline 139-65-1 x x x 94 4-Amino-2-nitrophenol 119-34-6 x x 95 4-Aminobiphenyl (4-aminodiphenyl) 92-67-1 x x x 96 4-Chloro-o -phenylenediamine 95-83-0 x x x

97 4-Dimethylaminoazobenzene para -Dimethylaminoazobenz ene

60-11-7 x x x

98 4-Methylimidazole 822-36-6 x x x 99 4-Nitrobiphenyl 92-93-3 x x 100 4-Nitropyrene 57835-92-4 x x x

101 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) 4-Vinylcyclohexene diepoxide 106-87-6 x x

102 4-Vinylcyclohexene 100-40-3 x x x 4-Vinylcyclohexene 100-40-3 x x

103 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone 139-91-3 x x x

5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone 3795-88-8 x x

104 5-Chloro-o -toluidine and its strong acid salts --- x x 105 5-Methoxypsoralen with ultraviolet A therapy 484-20-8 x x x 106 5-Methylchrysene 3697-24-3 x x x 107 5-Nitroacenaphthene 602-87-9 x x x 108 6-Nitrochrysene 7496-02-8 x x x 109 7,12-Dimethylbenz(a)anthracene 57-97-6 x x 110 7H-Dibenzo[c,g]carbazole 194-59-2 x x x 111 8-Methoxypsoralen with ultraviolet A therapy 298-81-7 x x x 112 A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) 26148-68-5 x x x 113 Acetaldehyde 75-07-0 x x x x 114 Acetamide 60-35-5 x x x 115 Acetazolamide 59-66-5 x x 116 Acetochlor 34256-82-1 x x 117 Acetohydroxamic acid 546-88-3 x x




Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

118 Acheson process, occupational exposure associated with --- x x

119 Acid mists, strong inorganic --- x x 120 Acifluorfen sodium 62476-59-9 x x 121 Acrylamide 79-06-1 x x x x x

Acrylamide 79-06-1 x x x x 122 Acrylonitrile 107-13-1 x x x x x 123 Actinomycin D 50-76-0 x x x 124 AF-2 [2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide] 3688-53-7 x x x 125 Aflatoxins --- x x x 126 Aflatoxins M1 6795-23-9 x x 127 Alachlor 15972-60-8 x x 128 Alcoholic beverages --- x x

129 Alcoholic beverages, when associated with alcohol abuse --- x x x

130 Aldrin 309-00-2 x x 131 All-trans retinoic acid Tretinoin 302-79-4 x x 132 Aloe vera, non-decolorized whole leaf extract --- x x 133 Aloe vera, whole leaf extract --- x x

134 alpha-Chlorinated toluenes (benzal chloride, benzotric chloride, benzyl chloride) and benzoyl chloride (combined exposures)

98-87-3 x x

alpha-Chlorinated toluenes (benzal chloride, benzotric chloride, benzyl chloride) and benzoyl chloride (combined exposures)

98-07-7 x x


100-44-7 x x


98-88-4 x x

135 Alprazolam 28981-97-7 x x 136 Altretamine 645-05-6 x x x 137 Amantadine hydrochloride 665-66-7 x x 138 Amikacin sulfate 39831-55-5 x x 139 Aminoglutethimide 125-84-8 x x




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140 Aminoglycosides --- x x 141 Aminopterin 54-62-6 x x x 142 Amiodarone hydrochloride 19774-82-4 x x x x 143 Amitraz 33089-61-1 x x x 144 Amitrole 61-82-5 x x 145 Amoxapine 14028-44-5 x x 146 Amsacrine 51264-14-3 x x x 147 Anabolic steroids --- x x x 148 Analgesic mixtures containing Phenacetin --- x x 149 Androgenic (anabolic) steriods --- x x 150 Androstenedione 63-05-8 x x x 151 Angiotensin converting enzyme (ACE) inhibitors --- x x 152 Aniline 62-53-3 x x x 153 Aniline hydrochloride 142-04-1 x x x 154 Anisindione 117-37-3 x x 155 Anthraquinone 84-65-1 x x x 156 Antimony oxide (Antimony trioxide) 1309-64-4 x x x 157 Aramite 140-57-8 x x x x 158 Areca nut --- x x x 159 Aristolochic acid, plants containing 313-67-7 x x 160 Aristolochic acids --- x x x x 161 Arsenic (inorganic arsenic compounds) --- x x x 162 Arsenic (inorganic oxides) --- x x 163 Arsenic and Inorganic Arsenic Compounds --- x x x 164 Asbestos 1332-21-4 x x x x

Asbestos 13768-00-8 Asbestos 17068-78-9 Asbestos 14567-73-8 Asbestos Acinolite 77536-66-4 Asbestos Amosite 12172-73-5 Asbestos Anthrophyllite 77536-67-5 Asbestos Chrysotile 12001-29-5 Asbestos Crocidolite 12004-28-4 Asbestos Tremolite 77536-68-6

165 Aspirin Acetylsalicylic acid 50-78-2 x x x 166 Atenolol 29122-68-7 x x




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167 Atrazine 1912-24-9 x x x 168 Auramine 492-80-8 x x x 169 Auranofin 34031-32-8 x x 170 Avermectin B1 (Abamectin) 71751-41-2 x x 171 Azacitidine 320-67-2 x x x 172 Azaserine 115-02-6 x x x 173 Azathioprine 446-86-6 x x x

Azathioprine 446-86-6 x x x 174 Aziridine 151-56-4 x x 175 Azobenzene 103-33-3 x x x 176 Barbiturates --- x x 177 Beclomethasone dipropionate 5534-09-8 x x 178 Benomyl 17804-35-2 x x x 179 Benthiavalicarb-isopropyl 177406-68-7 x x

Benthiavalicarb-isopropyl 177406-68-7 x x 180 Benz[a]anthracene 56-55-3 x x x 181 Benz[j]aceanthrylene 202-33-5 x x 182 Benzene 71-43-2 x x x x

Benzene 71-43-2 x x x 183 Benzidine [and its salts] 92-87-5 x x x x 184 Benzidine-based dyes --- x x x 185 Benzo[a]pyrene 50-32-8 x x x x 186 Benzo[b]fluoranthene 205-99-2 x x x 187 Benzo[c]phenanthrene 195-19-7 x x 188 Benzo[j]fluoranthene 205-82-3 x x x 189 Benzo[k]fluoranthene 207-08-9 x x x 190 Benzodiazepines --- x x 191 Benzofuran 271-89-6 x x x 192 Benzophenone 119-61-9 x x x 193 Benzotrichloride 98-07-7 x x x 194 Benzphetamine hydrochloride 5411-22-3 x x 195 Benzyl chloride 100-44-7 x x x 196 Benzyl violet 4B 1694-09-3 x x x 197 Beryllium and beryllium compounds --- x x x x 198 beta-Butyrolactone 3068-88-0 x x x 199 beta-Myrcene 123-35-3 x x




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200 beta-Propiolactone 57-57-8 x x x 201 Betel quid with tobacco --- x x x 202 Betel quid without tobacco --- x x x

203 Bis(2-chloro-1-methylethyl)ether, technical grade --- x x

204 Bis(2-chloroethyl)ether BCEE 111-44-4 x x 205 Bis(chloromethyl)ether BCME 542-88-1 x x x 206 Bischloroethyl nitrosourea (BCNU) (Carmustine) 154-93-8 x x x

Bischloroethyl nitrosourea (BCNU) (Carmustine) 154-93-8 x x 207 Bisphenol A (BPA) 80-05-7 x x

208 Bitumens, extracts of steam-refined and air refined --- x x

209 Bleomycins 11056-06-7 x x 210 Bracken fern --- x x x 211 Bromacil lithium salt 53404-19-6 x x

Bromacil lithium salt 53404-19-6 x x x 212 Bromate 15541-45-4 x x x 213 Bromochloroacetic acid 5589-96-8 x x x x 214 Bromodichloroacetic acid 7133-14-7 x x 215 Bromodichloromethane 75-27-4 x x x x 216 Bromoethane 74-96-4 x x x 217 Bromoform 75-25-2 x x x 218 Bromoxynil 1689-84-5 x x 219 Bromoxynil octanoate 1689-99-2 x x x 220 Butabarbital sodium 143-81-7 x x 221 Butyl benzyl phthalate (BBP) 85-68-7 x x x 222 Butylated hydroxyanisole (BHA) 25013-16-5 x x x 223 C.I. Acid Red 114 6459-94-5 x x x 224 C.I. Basic Red 9 monohydrochloride CI Basic Red 9 569-61-9 x x x 225 C.I. Direct Blue 15 2429-74-5 x x x 226 C.I. Direct Blue 218 28407-37-6 x x x 227 C.I. Disperse Yellow 3 2832-40-8 x x 228 C.I. Solvent Yellow 14 842-07-9 x x x 229 Cacodylic acid Dimethylarsinic acid 75-60-5 x x x 230 Cadmium --- x x x 231 Cadmium and cadmium compounds --- x x x




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232 Caffeic acid 331-39-5 x x x 233 Captafol 2425-06-1 x x x x 234 Captan 133-06-2 x x 235 Carbamazepine 298-46-4 x x 236 Carbaryl 63-25-2 x x x

Carbaryl 63-25-2 x x x x 237 Carbazole 86-74-8 x x x 238 Carbon black 1333-86-4 x x

239 Carbon black (airborne, unbound particles of respirable size) 1333-86-4 x x

240 Carbon disulfide 75-15-0 x x x x 241 Carbon monoxide 630-08-0 x x 242 Carbon nanotubes, multi-walled MWCNT-7 308068-56-6 x x 243 Carbon tetrachloride 56-23-5 x x x x 244 Carbon-black extracts --- x x 245 Carboplatin 41575-94-4 x x 246 Catechol 120-80-9 x x x

247 Ceramic fibers (airborne particles of respirable size) --- x x

248 Certain combined chemotherapy for lymphomas --- x x 249 Chenodiol 474-25-9 x x 250 Chloral 75-87-6 x x x 251 Chloral hydrate 302-17-0 x x x 252 Chlorambucil 305-03-3 x x x

Chlorambucil 305-03-3 x x 253 Chloramphenicol sodium succinate 982-57-0 x x 254 Chlorcyclizine hydrochloride 1620-21-9 x x 255 Chlordane 57-74-9 x x x 256 Chlordane (technical) 12789-03-6 x x 257 Chlordecone (Kepone) 143-50-0 x x x x x

Chlordecone (Kepone) 143-50-0 x x 258 Chlordiazepoxide 58-25-3 x x 259 Chlordiazepoxide hydrochloride 438-41-5 x x 260 Chlordimeform 6164-98-3 x x 261 Chlorendic acid 115-28-6 x x x




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262 Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) 108171-26-2 x x x

263 Chloroethane (Ethyl chloride) 75-00-3 x x 264 Chloroform 67-66-3 x x x x

Chloroform 67-66-3 x x 265 Chloromethyl methyl ether (technical grade) 107-30-2 x x x 266 Chlorophenoxy herbicides --- x x 267 Chloroprene 126-99-8 x x x x x 268 Chlorothalonil 1897-45-6 x x x 269 Chlorotrianisene 569-57-3 x x 270 Chlorozotocin 54749-90-5 x x x 271 Chlorpyrifos 2921-88-2 x x 272 Chromium (hexavalent compounds) --- x x x x

Chromium (hexavalent compounds) --- x x x x 273 Chrysene 218-01-9 x x x 274 Ciclosporin (Cyclosporin A; Cyclosporine) 59865-13-3 x x x

Ciclosporin (Cyclosporin A; Cyclosporine) 79217-60-0 275 Cidofovir 113852-37-2 x x x x x 276 Cinnamyl anthranilate 87-29-6 x x 277 Cisplatin 15663-27-1 x x x 278 Citrus Red No. 2 6358-53-8 x x 279 Cladribine 4291-63-8 x x 280 Clarithromycin 81103-11-9 x x 281 Clobetasol propionate 25122-46-7 x x x 282 Clofibrate 637-07-0 x x 283 Clomiphene citrate 50-41-9 x x 284 Clorazepate dipotassium 57109-90-7 x x 285 CMNP (pyrazachlor) 6814-58-0 x x 286 Coal gasification x x 287 Coal tar distillation 8007-45-2 x x x

288 Coal, indoor emissions from household combustion of --- x x

289 Coal-tar pitch 65996-93-2 x x x 290 Cobalt [II] oxide 1307-96-6 x x




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291 Cobalt and Cobalt Compounds that release cobalt ions in vivo 7440-48-4 x x

292 Cobalt metal powder 7440-48-4 x x x 293 Cobalt sulfate 10124-43-3 x x 294 Cobalt sulfate and other soluble cobalt (II) salts x x 295 Cobalt sulfate heptahydrate 10026-24-1 x x x 296 Cocaine 50-36-2 x x x

297 Coconut oil diethanolamine condensate (cocamide diethanolamine) 68603-42-9 x x x x

Coconut oil diethanolamine condensate (cocamide diethanolamine) Coconut oil amides 61789-19-3

Coconut oil diethanolamine condensate (cocamide diethanolamine)

Coconut Fatty Acid Diethanolamide 68155-06-6

Coconut oil diethanolamine condensate (cocamide diethanolamine) Cocamide DEA

Coconut oil diethanolamine condensate (cocamide diethanolamine) Coconut diethanolamide

298 Codeine phosphate 52-28-8 x x 299 Coffee --- x x 300 Coke oven emissions --- x x x x 301 Colchicine 64-86-8 x x x 302 Conjugated estrogens --- x x x 303 Creosotes --- x x x 304 Cumene 98-82-8 x x x x 305 Cupferron 135-20-6 x x 306 Cyanazine 21725-46-2 x x 307 Cycasin 14901-08-7 x x x 308 Cycloate 1134-23-2 x x x 309 Cycloheximide 66-81-9 x x 310 Cyclopenta[cd ]pyrene 27208-37-3 x x x 311 Cyclophosphamide (anhydrous) 50-18-0 x x x

Cyclophosphamide (anhydrous) 50-18-0 x x x x 312 Cyclophosphamide (hydrated) 6055-19-2 x x x

Cyclophosphamide (hydrated) 6055-19-2 x x x x 313 Cyhexatin 13121-70-5 x x 314 Cytarabine 147-94-4 x x




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315 Cytembena 21739-91-3 x x x 316 D&C Orange No. 17 3468-63-1 x x 317 D&C Red No. 19 81-88-9 x x 318 D&C Red No. 8 2092-56-0 x x 319 D&C Red No. 9 5160-02-1 x x 320 Dacarbazine 4342-03-4 x x x

Dacarbazine 4342-03-4 x x 321 Daminozide 1596-84-5 x x 322 Danazol 17230-88-5 x x

323 Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) 117-10-2 x x x

324 Daunomycin 20830-81-3 x x x 325 Daunorubicin hydrochloride 23541-50-6 x x 326 DDD (Dichlorodiphenyl-dichloroethane) 72-54-8 x x

327 DDE (Dichlorodiphenyl-dichloroethylene) p,p'-Dichlorodiphenyldichlor oethylene

72-55-9 x x

328 DDT (Dichlorodiphenyl-trichloroethane) 4,4'-Dichlorodipheyltrichloro ethane

50-29-3 x x x

329 DDVP (Dichlorvos) 62-73-7 x x x x 330 Demeclocycline hydrochloride (internal use) 64-73-3 x x 331 Des-ethyl atrazine (DEA) 6190-65-4 x x x 332 Des-isopropyl atrazine (DIA) 1007-28-9 x x x 333 Di(2-ethylhexyl)phthalate 117-81-7 x x x x

Di(2-ethylhexyl)phthalate 117-81-7 x x x 334 Diazepam 439-14-5 x x 335 Diazinon 333-41-5 x x 336 Diazoaminobenzene 136-35-6 x x 337 Diazoxide 364-98-7 x x 338 Dibenz[a,c]anthracene 215-58-7 x x 339 Dibenz[a,h]acridine 226-36-8 x x x 340 Dibenz[a,h]anthracene 53-70-3 x x 341 Dibenz[a,j]acridine 224-42-0 x x x 342 Dibenz[a,j]anthracene 224-41-9 x x 343 Dibenz[c,h]acridine 224-53-3 x x




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344 Dibenzanthracenes --- x x 345 Dibenzo[a,e]pyrene 192-65-4 x x 346 Dibenzo[a,h]pyrene 189-64-0 x x x 347 Dibenzo[a,i]pyrene 189-55-9 x x x 348 Dibenzo[a,l]pyrene 191-30-0 x x x 349 Dibromoacetic acid 631-64-1 x x x 350 Dibromoacetonitrile 3252-43-5 x x x x 351 Dichloroacetic acid 79-43-6 x x x x

Dichloroacetic acid 79-43-6 x x x x 352 Dichloromethane (Methylene chloride) 75-09-2 x x x x 353 Dichlorophene 97-23-4 x x x 354 Dichlorphenamide 120-97-8 x x 355 Diclofop methyl 51338-27-3 x x x

Diclofop-methyl 51338-27-3 x x 356 Dicumarol 66-76-2 x x 357 Dieldrin 60-57-1 x x x x 358 Dieldrin, and aldrin metabolized to dieldrin 309-00-2 x x 359 Diepoxybutane 1464-53-5 x x 360 Diesel engine exhaust --- x x x 361 Diesel fuel, marine --- x x 362 Diethanolamine (DEA) 111-42-2 x x x 363 Diethyl sulfate 64-67-5 x x x 364 Diethylstilbestrol (DES) 56-53-1 x x x

Diethylstilbestrol (DES) 56-53-1 x x x 365 Diflunisal 22494-42-4 x x x 366 Diglycidyl resorcinol ether (DGRE) 101-90-6 x x x 367 Digoxin 20830-75-5 x x 368 Dihydroergotamine mesylate 6190-39-2 x x 369 Dihydrosafrole 94-58-6 x x x

370 Di-isodecyl phthalate (DIDP) 68515-49-1 26761-40-0 x x

371 Diisononyl phthalate (DINP) --- x x 372 Diisopropyl sulfate 2973-10-6 x x x 373 Diltiazem hydrochloride 33286-22-5 x x 374 Dimethyl sulfate 77-78-1 x x x 375 Dimethylcarbamoyl chloride 79-44-7 x x x




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376 Dimethylformamide N ,N -Dimethylformamide 68-12-2 x x x

377 Dimethylvinylchloride 1-Chloro-2-methylpropene 513-37-1 x x x

378 Di-n -butyl phthalate (DBP) 84-74-2 x x x x x 379 Di-n -hexyl phthalate (DnHP) 84-75-3 x x x 380 Dinitrotoluene (technical grade) --- x x x 381 Dinitrotoluene mixture, 2,4-/2,6- --- x x x 382 Dinocap 39300-45-3 x x 383 Dinoseb 88-85-7 x x x

384 Di-n -propyl isocinchomeronate (MGK Repellent 326) 136-45-8 x x

385 Diphenylhydantoin (Phenytoin) 57-41-0 x x x Diphenylhydantoin (Phenytoin) 57-41-0 x x

386 Diphenylhydantoin (Phenytoin), sodium salt 630-93-3 x x 387 Direct Black 38 (technical grade) 1937-37-7 x x 388 Direct Blue 6 (technical grade) 2602-46-2 x x 389 Direct Brown 95 (technical grade) 16071-86-6 x x 390 Disodium cyanodithioimidocarbonate 138-93-2 x x x 391 Disperse Blue 1 2475-45-8 x x x 392 Diuron 330-54-1 x x x 393 Doxorubicin hydrochloride (Adriamycin) 25316-40-9 x x x x 394 Doxycycline (internal use) 564-25-0 x x 395 Doxycycline calcium (internal use) 94088-85-4 x x 396 Doxycycline hyclate (internal use) 24390-14-5 x x 397 Doxycycline monohydrate (internal use) 17086-28-1 x x 398 Endrin 72-20-8 x x x 399 Environmental tobacco smoke (ETS) --- x x 400 Epichlorohydrin 106-89-8 x x x x

Epichlorohydrin 106-89-8 x x x 401 Epoxiconazole 135319-73-2 x x 402 Ergotamine tartrate 379-79-3 x x

403 Erionite 12510-42-8 66733-21-9 x x x

404 Estradiol 17B 50-28-2 x x 405 Estragole 140-67-0 x x




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406 Estrogen therapy, postmenopausal --- x x

407 Estrogen-progestogen (combined) used as menopausal therapy --- x x x x

408 Estrogens, nonsteroidal, e.g. diethylstilbestrol --- x x x 409 Estrogens, steroidal --- x x 410 Estrone 53-16-7 x x 411 Estropipate 7280-37-7 x x x 412 Ethanol in alcoholic beverages 64-17-5 x x x 413 Ethinylestradiol 57-63-6 x x 414 Ethionamide 536-33-4 x x 415 Ethoprop 13194-48-4 x x 416 Ethyl acrylate 140-88-5 x x x 417 Ethyl alcohol in alcoholic beverages --- x x 418 Ethyl dipropylthiocarbamate 759-94-4 x x x 419 Ethyl methanesulfonate 62-50-0 x x x 420 Ethyl-4,4'-dichlorobenzilate 510-15-6 x x 421 Ethylbenzene 100-41-4 x x x 422 Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x x

Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x 423 Ethylene dichloride (1,2-Dichloroethane) 107-06-2 x x x x 424 Ethylene glycol (ingested) 107-21-1 x x 425 Ethylene glycol monoethyl ether 110-80-5 x x x 426 Ethylene glycol monoethyl ether acetate 111-15-9 x x x 427 Ethylene glycol monomethyl ether 109-86-4 x x x 428 Ethylene glycol monomethyl ether acetate 110-49-6 x x x 429 Ethylene oxide 75-21-8 x x x x x

Ethylene oxide 75-21-8 x x x x 430 Ethylene thiourea 96-45-7 x x x

Ethylene thiourea 96-45-7 x x 431 Ethyleneimine 151-56-4 x x 432 Etodolac 41340-25-4 x x x 433 Etoposide 33419-42-0 x x x

Etoposide 33419-42-0 x x

434 Etoposide in combination with cisplatin and bleomycin 33419-42-0 x x x




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Etoposide in combination with cisplatin and bleomycin 15663-27-1

Etoposide in combination with cisplatin and bleomycin 11056-06-7

435 Etretinate 54350-48-0 x x 436 Fenoxaprop ethyl 66441-23-4 x x x 437 Fenoxycarb 72490-01-8 x x x 438 Filgrastim 121181-53-1 x x 439 Fluazifop butyl 69806-50-4 x x x 440 Flunisolide 3385-03-3 x x x 441 Fluoro-edenite fibrous amphibole --- x x 442 Fluorouracil 51-21-8 x x 443 Fluoxetine 54910-89-3 x x x x 444 Fluoxetine hydrochloride (Prozac) 59333-67-4 x x x x

Fluoxetine hydrochloride (Prozac) 56296-78-7 x x x x 445 Fluoxymesterone 76-43-7 x x 446 Flurazepam hydrochloride 1172-18-5 x x 447 Flurbiprofen 5104-49-4 x x x 448 Flutamide 13311-84-7 x x 449 Fluticasone propionate 80474-14-2 x x 450 Fluvalinate 69409-94-5 x x x 451 Folpet 133-07-3 x x x 452 Formaldehyde 50-00-0 x x x x

Formaldehyde Methylene glycol 463-57-0 x Formaldehyde Methanediol Formaldehyde Formalin 30525-89-4 x

453 Formaldehyde (gas) 50-00-0 x x 454 Fuel oils, residual (heavy) --- x x 455 Fumonisin B1 116355-83-0 x x x x 456 Furan 110-00-9 x x x 457 Furazole (Mon 13900) 121776-33-8 x x 458 Furazolidone 67-45-8 x x x 459 Furfuryl alcohol 98-00-0 x x x 460 Furmecyclox 60568-05-0 x x x 461 Fusarin C 79748-81-5 x x




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462 Fusarium moniliforme, toxins derived from (fumonisin B1, fumonisin B2, and fusarin C 116355-83-0 x x

463 Gallium arsenide 1303-00-0 x x Gallium arsenide 1303-00-0 x x

464 Ganciclovir 82410-32-0 x x x x 465 Ganciclovir sodium 107910-75-8 x x x 466 Gasoline --- x x 467 Gasoline engine exhaust (condensates/extracts) --- x x x 468 Gemfibrozil 25812-30-0 x x x x 469 Ginkgo biloba extract 90045-36-6 x x 470 Glass wool fibers (inhalable and biopersistent) --- x x 471 Glass Wool Fibers (Inhalable) --- x

472 Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole) 67730-11-4 x x x

473 Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) 67730-10-3 x x x

474 Glycidaldehyde 765-34-4 x x x 475 Glycidol 556-52-5 x x x 476 Glyphosate 1071-83-6 x x x 477 Goldenseal root powder --- x x x 478 Goserelin acetate 65807-02-5 x x x x 479 Griseofulvin 126-07-8 x x x

480 Gyromitrin (Acetaldehyde methylformylhydrazone) 16568-02-8 x x

481 Hairdresser or barber (occupational exposure as a) --- x x

482 Halazepam 23092-17-3 x x 483 Halobetasol propionate 66852-54-8 x x 484 Haloperidol 52-86-8 x x x 485 Halothane 151-67-7 x x 486 Haloxyfop-methyl (Verdict) 69806-40-2 x x 487 HC Blue 1 2784-94-3 x x x 488 Heptachlor 76-44-8 x x x x

Heptachlor 76-44-8 x x x 489 Heptachlor epoxide 1024-57-3 x x x




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490 Herbal remedies containing plant species of the genus Aristolochia --- x x

491 Hexachlorobenzene 118-74-1 x x x x Hexachlorobenzene 118-74-1 x x

492 Hexachlorobutadiene 87-68-3 x x x 493 Hexachlorocyclohexane (alpha isomer) alpha-HCH 319-84-6 x x x 494 Hexachlorocyclohexane (beta isomer) --- x x x 495 Hexachlorocyclohexane (gamma isomer) --- x x x 496 Hexachlorocyclohexane (technical grade) t-HCH 608-73-1 x x x 497 Hexachlorodibenzodioxin 34465-46- 8 x x

498 Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 x x

499 Hexachloroethane 67-72-1 x x x x 500 Hexafluoroacetone 684-16-2 x x x 501 Hexamethylphosphoramide 680-31-9 x x x

Hexamethylphosphoramide 680-31-9 x x 502 Histrelin acetate --- x x 503 Hydramethylnon 67485-29-4 x x x x 504 Hydrazine 302-01-2 x x x x 505 Hydrazine sulfate 10034-93-2 x x 506 Hydrazobenzene (1,2-Diphenylhydrazine) 122-66-7 x x x 507 Hydrochlorothiazide 58-93-5 x x

508 Hydrogen cyanide (HCN) & cyanide salts (CN salts) --- x x

509 Hydroxyurea 127-07-1 x x 510 Idarubicin hydrochloride 57852-57-0 x x x 511 Ifosfamide 3778-73-2 x x 512 Imazalil 35554-44-0 x x

Imazalil 35554-44-0 x x 513 Indeno [1,2,3-cd]pyrene 193-39-5 x x x 514 Indium phosphide 22398-80-7 x x x x 515 Indium tin oxide 50926-11-9 x x 516 Iodine-131 10043-66-0 x x 517 Iprodione 36734-19-7 x x 518 Iprovalicarb 140923-25-7 x x

Iprovalicarb 140923-17-7 x x




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NTP - RoC

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519 IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) 76180-96-6 x x x 520 Iron dextran complex 9004-66-4 x x x 521 Isobutyl nitrite 542-56-3 x x 522 Isoprene 78-79-5 x x x 523 Isopropyl alcohol manufacture using strong acids --- x x 524 Isopyrazam 881685-58-1 x x x 525 Isotretinoin 4759-48-2 x x 526 Isoxaflutole 141112-29-0 x x x 527 Kava extract 9000-38-8 x x 528 Kresoxim-methyl 143390-89-0 x x x 529 Lactofen 77501-63-4 x x 530 Lasiocarpine 303-34-4 x x x 531 Lead --- x x x x 532 Lead acetate 301-04-2 x x 533 Lead and lead compounds --- x x x 534 Lead phosphate 7446-27-7 x x 535 Lead subacetate 1335-32-6 x x 536 Leather dust --- x x x 537 Leuprolide acetate 74381-53-6 x x x x 538 Levodopa 59-92-7 x x 539 Levonorgestrel implants 797-63-7 x x 540 Libby Amphibole asbestos (inhalation route) --- x x

541 Lindane and other hexachlorocyclohexane isomers 58-89-9 x x x

542 Linuron 330-55-2 x x x 543 Lithium carbonate 554-13-2 x x 544 Lithium citrate 919-16-4 x x 545 Lorazepam 846-49-1 x x 546 Lovastatin 75330-75-5 x x 547 Lynestrenol 52-76-6 x x x 548 Magenta 632-99-5 x x 549 Magenta production --- x x

550 Malaria (caused by infection with Plasmodium falciparum in holoendemic areas) --- x x

551 Malathion 121-75-5 x x x 552 Malonaldehyde, sodium salt 24382-04-5 x x x




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553 Mancozeb 8018-01-7 x x 554 Maneb 12427-38-2 x x 555 Marijuana smoke --- x x 556 Mate, hot --- x x 557 m -Dinitrobenzene 99-65-0 x x x

558 Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) 68006-83-7 x x x

559 Mebendazole 31431-39-7 x x 560 Medroxyprogesterone acetate 71-58-9 x x x

Medroxyprogesterone acetate 71-58-9 x x 561 Megestrol acetate 595-33-5 x x x 562 Melamine 108-78-1 x x

563 MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) 77094-11-2 x x x

564 MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) 77500-04-0 x x x

565 Melphalan 148-82-3 x x x Melphalan 148-82-3 x x x

566 Menotropins 9002-68-0 x x 567 Mepanipyrim 110235-47-7 x x

Mepanipyrim 110235-47-7 x x 568 Meprobamate 57-53-4 x x 569 Mercaptopurine 6112-76-1 x x 570 Mercury and mercury compounds --- x x 571 Merphalan 531-76-0 x x x 572 Mestranol 72-33-3 x x 573 Metam potassium 137-41-7 x x 574 Methacycline hydrochloride 3963-95-9 x x 575 Metham sodium 137-42-8 x x x

Metham sodium 137-42-8 x x x 576 Methanol 67-56-1 x x x 577 Methazole 20354-26-1 x x 578 Methimazole 60-56-0 x x x 579 Methotrexate 59-05-2 x x 580 Methotrexate sodium 15475-56-6 x x 581 Methyl bromide, as a structural fumigant 74-83-9 x x




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582 Methyl carbamate 598-55-0 x x x 583 Methyl chloride 74-87-3 x x x 584 Methyl iodide 74-88-4 x x 585 Methyl isobutyl ketone 108-10-1 x x x

Methyl isobutyl ketone 108-10-1 x x x 586 Methyl isocyanate (MIC) 624-83-9 x x x 587 Methyl isothiocyanate 556-61-6 x x 588 Methyl mercury --- x x 589 Methyl methanesulfonate 66-27-3 x x x 590 Methyl n-butyl ketone 591-78-6 x x x 591 Methylazoxymethanol 590-96-5 x x 592 Methylazoxymethanol acetate 592-62-1 x x x 593 Methylene bis (thiocyanate) 6317-18-6 x x 594 Methyleugenol 93-15-2 x x x x 595 Methylhydrazine and its salts --- x 596 Methylmercury compounds --- x x x 597 Methyltestosterone 58-18-4 x x 598 Methylthiouracil 56-04-2 x x x 599 Metiram 9006-42-2 x x x x 600 Metronidazole 443-48-1 x x x

601 Michler's ketone ( [4,4'-Bis(dimethylamoni)benzophenone) 90-94-8 x x x

602 Microcystin-LR 101043-37-2 x x 603 Midazolam hydrochloride 59467-96-8 x x 604 Mineral oils, untreated and mildly treated --- x x x 605 Minocycline hydrochloride (internal use) 13614-98-7 x x 606 Mirex 2385-85-5 x x x 607 Misoprostol 59122-46-2 x x 608 Mitomycin C 50-07-7 x x x 609 Mitoxantrone hydrochloride 70476-82-3 x x x 610 Molinate 2212-67-1 x x x x x 611 Molybdenum trioxide 1313-27-5 x x 612 MON 13900 (furilazole) 121776-33-8 x x

613 MON 4660 (4-(dichloroacetyl)-1-oxa-4-azaspiro[4,5]decane) 71526-07-3 x x




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614 MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4,5)-decane 71526-07-3 x x

615 Monocrotaline 315-22-0 x x x 616 Monomethylarsonic acid Methylarsonic acid 124-58-3 x x

617 MOPP (vincristine-prednisone-nitrogen mustard-procarbazine combination chemotherapy regimen) 113803-47-7 x x x

618 Mustard Gas Sulfur mustard 505-60-2 x x

619 MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) 77439-76-0 x x x

620 Myclobutanil 88671-89-0 x x x x

621 N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) 494-03-1 x x x

622 N,N'-Diacetylbenzidine 613-35-4 x x x 623 N,N-Dimethylacetamide 127-19-5 x x x 624 N,N -Dimethyl-p -toluidine Dimethyl-p -toluidine 99-97-8 x x x x 625 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 531-82-8 x x x 626 Nabam 142-59-6 x x x 627 Nafarelin acetate 86220-42-0 x x 628 Nafenopin 3771-19-5 x x x 629 Nalidixic acid 389-08-2 x x x 630 Naphthalene 91-20-3 x x x x 631 N-Carboxymethyl-N-nitrosourea 60391-92-6 x x 632 Neomycin sulfate (internal use) 1405-10-3 x x 633 Netilmicin sulfate 56391-57-2 x x 634 Neutron radiation --- x x 635 n-Hexane 110-54-3 x x 636 Nickel (Metallic) 7440-02-0 x x 637 Nickel acetate 373-02-4 x x 638 Nickel carbonate 3333-67-3 x x 639 Nickel carbonyl 13463-39-3 x x x 640 Nickel compounds --- x x x

641 Nickel hydroxide 12054-48-7 12125-56-3 x x

642 Nickel oxide 1313-99-1 x x




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643 Nickel refinery dust from the pyrometallurgical process --- x x

644 Nickel subsulfide 12035-72-2 x x x 645 Nickel, metallic and alloys x x 646 Nickelocene 1271-28-9 x x 647 Nicotine 54-11-5 x x 648 Nifedipine 21829-25-4 x x x x 649 Nimodipine 66085-59-4 x x 650 Niridazole 61-57-4 x x x 651 Nitrapyrin 1929-82-4 x x x x

652 Nitrate or nitrite, ingested under conditions that result in endogenous nitrosation --- x x

653 Nitrilotriacetic acid and its salts 139-13-9 x x x 654 Nitrilotriacetic acid, trisodium salt monohydrate 18662-53-8 x x 655 Nitrobenzene 98-95-3 x x x x

Nitrobenzene 98-95-3 x x x 656 Nitrofen (technical grade) 1836-75-5 x x x 657 Nitrofurantoin 67-20-9 x x 658 Nitrofurazone 59-87-0 x x 659 Nitrogen mustard (Mechlorethamine) 51-75-2 x x x

Nitrogen mustard (Mechlorethamine) 51-75-2 x x

660 Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) 55-86-7 x x

Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) 55-86-7 x x

661 Nitrogen mustard N-oxide 126-85-2 x x x 662 Nitrogen mustard N-oxide hydrochloride 302-70-5 x x 663 Nitromethane 75-52-5 x x x x 664 Nitrous oxide 10024-97-2 x x x 665 N-Methyl-N'-nitro-N-nitrosoguanidine 70-25-7 x x x 666 N-Methylolacrylamide 924-42-5 x x 667 N-Methylpyrrolidone 872-50-4 x x x 668 N-Nitrosodiethanolamine 1116-54-7 x x x x 669 N-Nitrosodiethylamine 55-18-5 x x x x 670 N-Nitrosodimethylamine 62-75-9 x x x x 671 N-Nitrosodi-n -butylamine 924-16-3 x x x x




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672 N-Nitrosodi-n -propylamine 621-64-7 x x x x 673 N-Nitrosodiphenylamine 86-30-6 x x x 674 N-Nitrosomethylethylamine 10595-95-6 x x x 675 N-Nitrosomethyl-n -butylamine 7068-83-9 x x 676 N-Nitrosomethyl-n -decylamine 75881-22-0 x x 677 N-Nitrosomethyl-n -dodecylamine 55090-44-3 x x 678 N-Nitrosomethyl-n -heptylamine 16338-99-1 x x 679 N-Nitrosomethyl-n -hexylamine 28538-70-7 x x 680 N-Nitrosomethyl-n -nonylamine 75881-19-5 x x 681 N-Nitrosomethyl-n -octylamine 34423-54-6 x x 682 N-Nitrosomethyl-n -pentylamine 13256-07-0 x x 683 N-Nitrosomethyl-n -propylamine 924-46-9 x x 684 N-Nitrosomethyl-n -tetradecylamine 75881-20-8 x x 685 N-Nitrosomethyl-n -undecylamine 68107-26-6 x x 686 N-Nitrosomethylvinylamine 4549-40-0 x x x 687 N-Nitrosomorpholine 59-89-2 x x x 688 N-Nitroso-N-ethylurea 759-73-9 x x x 689 N-Nitroso-N-methylurea 684-93-5 x x x 690 N-Nitroso-N-methylurethane 615-53-2 x x x 691 N-Nitrosonornicotine 16543-55-8 x x x 692 N-Nitrosopiperidine 100-75-4 x x x 693 N-Nitrosopyrrolidine 930-55-2 x x x x 694 N-Nitrososarcosine 13256-22-9 x x x 695 Norethisterone (Norethindrone) 68-22-4 x x x

696 Norethisterone (Norethindrone)/Ethinyl estradiol 68-22-4 57-63-6 x x

697 Norethisterone (Norethindrone)/Mestranol 68-22-4 72-33-3 x x x

698 Norethisterone acetate (Norethindrone acetate) 51-98-9 x x 699 Norethynodrel 68-23-5 x x x 700 Norgestrel 6533-00-2 x x 701 o,p'-DDT 789-02-6 x x x x x x 702 o -Aminoazotoluene 97-56-3 x x x 703 o -Anisidine 90-04-0 x x x 704 o -Anisidine hydrochloride 134-29-2 x x 705 Ochratoxin A 303-47-9 x x x




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706 o -Dinitrobenzene 528-29-0 x x 707 Oil Orange SS 2646-17-5 x x x 708 o -Nitroanisole 2-Nitroanisole 91-23-6 x x x 709 o -Nitrotoluene 88-72-2 x x x x 710 o -Phenylenediamine --- x x 711 o -Phenylenediamine and its salts 95-54-5 x x 712 o -Phenylenediamine dihydochloride --- x 713 o -Phenylphenate, sodium 132-27-4 x x x 714 o -Phenylphenol 90-43-7 x x x 715 Oral contraceptives, combined --- x x x 716 Oral contraceptives, sequential --- x x 717 Oryzalin 19044-88-3 x x x 718 o -Toluidine 2-methylbenzenamine 95-53-4 x x x x 719 o -Toluidine hydrochloride 636-21-5 x x 720 Oxadiazon 19666-30-9 x x

Oxadiazon 19666-30-9 x x x 721 Oxazepam 604-75-1 x x x

Oxazepam 604-75-1 x x 722 Oxydemeton methyl 301-12-2 x x x x 723 Oxymetholone 434-07-1 x x x 724 Oxytetracycline (internal use) 79-57-2 x x 725 Oxytetracycline hydrochloride (internal use) 2058-46-0 x x 726 Oxythioquinox (Chinomethionat) 2439-01-2 x x x x 727 p,p'-DDT 50-29-3 x x x x x x 728 p-a,a,a-Tetrachlorotoluene 5216-25-1 x x 729 Paclitaxel 33069-62-4 x x x x 730 Palygorskite fibers (> 5 micrometers in length) Attapulgite 12174-11-7 x x x 731 p -Aminoazobenzene 60-09-3 x x x 732 Panfuran S 794-93-4 x x x 733 Paramethadione 115-67-3 x x 734 Parathion 56-38-2 x x x 735 p -Chloroaniline 106-47-8 x x x 736 p -Chloroaniline hydrochloride 20265-96-7 x x x 737 p -Chloro-o -toluidine 95-69-2 x x x 738 p-Chloro-o -toluidine, hydrochloride --- x 739 p-Chloro-o -toluidine, strong acid salts of --- x x x




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740 p -Cresidine 120-71-8 x x x 741 p -Dichlorobenzene 106-46-7 x x x 742 p -Dinitrobenzene 100-25-4 x x 743 Penicillamine 52-67-5 x x

744 Pentabromodiphenyl ether mixture [DE-71 (technical grade)] --- x x

745 Pentachlorophenol Pentachlorophenol and by-products of its synthesis

87-86-5 x x x x

746 Pentachlorophenol, sodium salt Pentachlorophenol and by-products of its synthesis

131-52-2 x x

747 Pentobarbital sodium 57-33-0 x x 748 Pentosan polysulfate sodium 37319-17-8 x x

Pentosan polysulfate sodium --- x 749 Pentostatin 53910-25-1 x x 750 Perfluorooctane sulfonate PFOS 1763-23-1 x x 751 Perfluorooctanoic acid PFOA 335-67-1 x x

Perfluorooctanoic acid PFOA 335-67-1 x x 752 Permethrin 52645-53-1 x x 753 Phenacemide 63-98-9 x x 754 Phenacetin 62-44-2 x x x 755 Phenacetin, analgesic mixtures containing --- x x 756 Phenazopyridine 94-78-0 x x 757 Phenazopyridine hydrochloride 136-40-3 x x x 758 Phenesterin 3546-10-9 x x 759 Phenobarbital 50-06-6 x x x x 760 Phenolphthalein 77-09-8 x x x 761 Phenoxybenzamine 59-96-1 x x 762 Phenoxybenzamine hydrochloride 63-92-3 x x x 763 Phenprocoumon 435-97-2 x x 764 Phenyl glycidyl ether 122-60-1 x x x 765 Phenylhydrazine --- x 766 Phenylhydrazine and its salts --- x x 767 Phenylhydrazine hydrochloride --- x 768 Phenylphosphine 638-21-1 x x




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769 PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) 105650-23-5 x x x

770 Phosphorus-32, as phosphate 14596-37-3 x x 771 Pickled vegetables (traditional in Asia) --- x x 772 Pimozide 2062-78-4 x x x 773 Pioglitazone 111025-46-8 x x x 774 Pipobroman 54-91-1 x x 775 Pirimicarb 23103-98-2 x x x 776 Plicamycin 18378-89-7 x x 777 p -Nitrosodiphenylamine 156-10-5 x x 778 Polybrominated biphenyls 59536-65-1 x x

Polybrominated biphenyls --- x x x 779 Polychlorinated biphenyls 1336-36-3 x x x

Polychlorinated biphenyls --- x x x

780 Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) --- x x

781

Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalent Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)

--- x x

782 Polychlorinated dibenzofurans --- x x 783 Polychlorinated dibenzo-p -dioxins --- x x

784 Polychlorophenols and their sodium salts (mixed exposures) --- x x

785 Polygeenan Carrageenan, degraded 53973-98-1 x x x

786 Ponceau 3R 3564-09-8 x x x 787 Ponceau MX 3761-53-3 x x x 788 Potassium bromate 7758-01-2 x x x x 789 Potassium dimethyldithiocarbamate 128-03-0 x x x 790 Pravastatin sodium 81131-70-6 x x 791 Prednisolone sodium phosphate 125-02-0 x x 792 Primidone 125-33-7 x x x x 793 Procarbazine 671-16-9 x x 794 Procarbazine hydrochloride 366-70-1 x x x x

Procarbazine hydrochloride 366-70-1 x x




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795 Procymidone 32809-16-8 x x 796 Progesterone 57-83-0 x x 797 Progestins --- x x 798 Pronamide 23950-58-5 x x 799 Propachlor 1918-16-7 x x x 800 Propargite 2312-35-8 x x x x 801 Propazine 139-40-2 x x x 802 Propoxur 114-26-1 x x x

803 Propylene glycol mono-t -butyl ether 1-tert -Butoxypropan-2-ol 57018-52-7 x x x x

804 Propylene oxide 75-56-9 x x x x 805 Propylthiouracil 51-52-5 x x x

Propylthiouracil 51-52-5 x x 806 Pulegone 89-82-7 x x x 807 Pymetrozine 123312-89-0 x x x 808 Pyraflufen-ethyl 129630-19-9 x x 809 Pyridine 110-86-1 x x x 810 Pyrimethamine 58-14-0 x x 811 Quazepam 36735-22-5 x x 812 Quinoline 91-22-5 x x 813 Quinoline and its strong acid salts --- x x x 814 Quizalofop-ethyl 76578-14-8 x x 815 Radionuclides --- x x x 816 Reserpine 50-55-5 x x 817 Residual (heavy) fuel oils --- x x x 818 Resmethrin 10453-86-8 x x x x

819

Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.)

x x




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Acetic acid, retinyl ester


all-trans-Retinol acetate 127-47-9


Reginol/retinyl palmitate


Retinyl hexadecamoate 79-81-2


Vitamin A 11103-57-4


Vitamin A palmitate 79-81-2




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820 Ribavirin 36791-04-5 x x x 821 Riddelliine 23246-96-0 x x x x 822 Rifampin 13292-46-1 x x x

823 S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF) 78-48-8 x x x

824 Safrole 94-59-7 x x x 825 Salted fish, Chinese-style --- x x x 826 Secobarbital sodium 309-43-3 x x 827 Sedaxane 874967-67-6 x x 828 Selenium sulfide 7446-34-6 x x 829 Sermorelin acetate --- x x 830 Shale-oils 68308-34-9 x x x

831 Silica dust, crystalline, in the form of quartz or cristoballite 14808-60-7 x x

832 Silica, crystalline (airborne particles of respirable size) x x

Silica, crystalline (airborne particles of respirable size) Tripoli 1317-95-9

Silica, crystalline (airborne particles of respirable size) Cristobalite 14464-46-1

Silica, crystalline (airborne particles of respirable size) Quartz 14808-60-7

Silica, crystalline (airborne particles of respirable size) Tridymite 15468-32-3

833 Silicon carbide whiskers 409-21-2 x x 834 Silicon carbide, fibrous 308076-74-6 x x 835 Simazine 122-34-9 x x x 836 Sodium dimethyldithiocarbamate 128-04-1 x x x 837 Sodium fluoroacetate 62-74-8 x x x

838 Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) --- x x x

839 Special-purpose fibres such as E-glass and '475' glass fibres --- x x

840 Spirodiclofen 148477-71-8 x x 841 Spironolactone 52-01-7 x x 842 Stanozolol 10418-03-8 x x




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843 Sterigmatocystin 10048-13-2 x x x 844 Streptomycin sulfate 3810-74-0 x x 845 Streptozocin (streptozotocin) 18883-66-4 x x x x 846 Streptozotocin (streptozocin) 18883-66-4 x x x

847 Strong inorganic acid mists containing sulfuric acid --- x x x

848 Styrene 100-42-5 x x x 849 Styrene oxide Styrene-7,8-oxide 96-09-3 x x x 850 Sulfallate 95-06-7 x x x 851 Sulfasalazine (salicylazosulfapyridine) 599-79-1 x x x x

Sulfasalazine (salicylazosulfapyridine) 599-79-1 x x x 852 Sulfosulfuron 141776-32-1 x x 853 Sulfur dioxide 7446-09-5 x x 854 Sulindac 38194-50-2 x x x 855 Talc containing asbestiform fibers --- x x x 856 Talc-based body powder (perineal use of) 14807-96-6 x x 857 Tamoxifen and its salts 10540-29-1 x x x 858 Tamoxifen citrate 54965-24-1 x x 859 Temazepam 846-50-4 x x 860 Teniposide 29767-20-2 x x

Teniposide 29767-20-2 x x 861 Terbacil 5902-51-2 x x x 862 Teriparatide 52232-67-4 x x 863 Terrazole 2593-15-9 x x 864 Testosterone and its esters 58-22-0 x x 865 Testosterone cypionate 58-20-8 x x 866 Testosterone enanthate 315-37-7 x x 867 Tetrabromobisphenol A 79-94-7 x x x 868 Tetrachloroethylene (Perchloroethylene) 127-18-4 x x x x 869 Tetrachlorvinphos 961-11-5 x x 870 Tetrachlorvinphos 22248-79-9 x x x 871 Tetracycline (internal use) 60-54-8 x x 872 Tetracycline hydrochloride (internal use) 64-75-5 x x 873 Tetracyclines (internal use) --- x x 874 Tetrafluoroethylene 116-14-3 x x x x 875 Tetrahydrofuran 109-99-9 x x




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876 Tetranitromethane 509-14-8 x x x 877 Thalidomide 50-35-1 x x 878 Thiabendazole 148-79-8 x x 879 Thialcorprid 111988-49-9 x x 880 Thioacetamide 62-55-5 x x x 881 Thiodicarb 59669-26-0 x x x 882 Thioguanine 154-42-7 x x 883 Thiophanate methyl 23564-05-8 x x x x 884 Thiouracil 141-90-2 x x x 885 Thiourea 62-56-6 x x 886 Thorium dioxide 1314-20-1 x x 887 Titanium dioxide 13463-67-7 x x

Titanium dioxide 1317-70-0 x x Titanium dioxide 1317-80-2 x x Titanium dioxide 98084-96-9

888 Titanium dioxide (airborne, unbound particles of respirable size) --- x x

889 Tobacco smoke --- x x x 890 Tobacco smoke (primary) --- x x x x 891 Tobacco, oral use of smokeless products --- x x x 892 Tobramycin sulfate 49842-07-1 x x 893 Toluene 108-88-3 x x 894 Toluene diisocyanate 26471-62-5 x x x 895 Tolyfluanid 731-27-1 x x 896 Topiramate 97240-79-4 x x 897 Toxaphene (Polychlorinated camphenes) 8001-35-2 x x x x

898 Toxins derived from Fusarium moniliforme (Fusarium verticillioides) --- x x

899 trans -2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole 55738-54-0 x x

trans -2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole 25962-77-0 x x

900 Treosulfan 299-75-2 x x x 901 Triadimefon 43121-43-3 x x x x x 902 Triamterene 396-01-0 x x x 903 Triazolam 28911-01-5 x x




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NTP - OHAT

904 Tribufos 78-48-8 x x 905 Tributyltin methacrylate 2155-70-6 x x x 906 Trichlorfon 52-68-6 x x 907 Trichlormethine (Trimustine hydrochloride) 817-09-4 x x x 908 Trichloroacetic acid 76-03-9 x x x x 909 Trichloroethylene 79-01-6 x x x x x

Trichloroethylene 79-01-6 x x x 910 Trientine hydrochloride 38260-01-4 x x 911 Triforine 26644-46-2 x x x 912 Trilostane 13647-35-3 x x 913 TRIM® VX --- x x 914 Trimethadione 127-48-0 x x 915 Trimethyl phosphate 512-56-1 x x 916 Trimetrexate glucuronate 82952-64-5 x x 917 Triphenyltin hydroxide 76-87-9 x x x x 918 Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) 13674-87-8 x x 919 Tris(1-aziridinyl)phosphine sulfide (Thiotepa) 52-24-4 x x x 920 Tris(2,3-dibromopropyl)phosphate 126-72-7 x x x 921 Tris(2-chloroethyl) phosphate 115-96-8 x x 922 Trp-P-1 (Tryptophan-P-1) 62450-06-0 x x x 923 Trp-P-2 (Tryptophan-P-2) 62450-07-1 x x x 924 Trypan blue 72-57-1 x x x 925 Tungsten carbide 12070-12-1 x x

926 Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC) --- x x

927 Ultraviolet-emitting tanning devices --- x x 928 Unleaded gasoline (wholly vaporized) --- x x 929 Uracil mustard 66-75-1 x x x

Uracil mustard 66-75-1 x x x x 930 Urethane (Ethyl carbamate) 51-79-6 x x x

Urethane (Ethyl carbamate) 51-79-6 x x 931 Urofollitropin 97048-13-0 x x 932 Valproate (Valproic acid) 99-66-1 x x

933 Vanadium pentoxide (orthorhombic crystalline form) 1314-62-1 x x x x

934 Vinblastine sulfate 143-67-9 x x




Cancer

Developmental

Female

Reproductive

Male

Reproductive

CalEPA -

Prop 65

IARC

EPA - IRIS

NTP - RoC

NTP - OHAT

935 Vinclozolin 50471-44-8 x x x x 936 Vincristine sulfate 2068-78-2 x x 937 Vinyl acetate 108-05-4 x x 938 Vinyl bromide 593-60-2 x x x 939 Vinyl chloride 75-01-4 x x x x

940 Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide) 106-87-6 x x

Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide) 106-87-6 x x

941 Vinyl fluoride 75-02-5 x x x 942 Vinyl trichloride (1,1,2-Trichloroethane) 79-00-5 x x x 943 Vinylidene chloride 75-35-4 x x x 944 Warfarin 81-81-2 x x 945 Welding fumes --- x x 946 Wood dust --- x x x 947 Zalcitabine 7481-89-2 x x x 948 Zalcitabine (ddC) 7481-89-2 x x 949 Zidovudine (AZT) 30516-87-1 x x x 950 Zileuton 111406-87-2 x x x x 951 α-Methyl styrene (alpha-Methylstyrene) 98-83-9 x x x


final testimony - oversight.house.gov

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