fish frog

chick

Walking the line of cytochrome P450 evolution

David R. Nelson

human

JGI Tree of Life July 18, 2006

(5)

(282)

(99)

(97)

(51)

(177)

(706)

Human Chr 1 vs. mouse

Phylogenetically Inferred Groups synteny viewer

Human Chr 1 vs. mouse and chicken

Phylogenetically Inferred Groups synteny viewer

Human Chr 7 vs. zebrafish

Phylogenetically Inferred Groups synteny viewer

Human Chr 5 vs. Ciona

Phylogenetically Inferred Groups synteny viewer

Human CYP2AC1P

Xenopus CYP2AC gene cluster

Human CYP2J2 and HOOK1

zebrafish CYP2P, CYP2V, CYP2AD and CYP2N gene cluster

chicken CYP2J cluster and HOOK1

Human CYP2ABFGST gene cluster

Xenopus CYP2Q gene cluster

Fugu CYP2Y1 and CYP2Y2 Zebrafish CYP2Y3

Human syntenic region of the Xenopus CYP2AB1 gene

Xenopus CYP2AB1

zebrafish syntenic region of the Xenopus CYP2AB1 gene

Chicken CYP2AB gene cluster

Human CYP2AB1P pseudogene

zebrafish KCNJ2 LILRA2 CYP2K gene cluster ABCA3

fugu centa1 RNPS1 CYP2K gene cluster ABCA3

tetraodon centa1 CYP2K gene cluster ABCA3

Xenopus centa1 CYP2W gene cluster c16orf28

chicken centa1 CYP2W gene cluster gpr146

human centa1 CYP2W1 gpr146

Synteny around the CYP2W and CYP2K gene clusters

Zebrafish Chr25 SETD6 CNOT1 CYP2X6-9 E2F4

Zebrafish Chr7 LEAP2 CYP2X10 zgc:100802 GOT2

Xenopus CNOT1 ---- zgc:100802 GOT2

chicken SETD6 CNOT1 ---- zgc:100802 GOT2

human SETD6 CNOT1 ---- zgc:100802 GOT2

Synteny around the CYP2X gene cluster

zebrafish CYP19 and gliomedin ortholog

human CYP19 and gliomedin

Ciona CYP20 and best BLAST hit to zebrafish gliomedin ortholog

human chr20 with CYP8A1 (2.7 Mb region)

human chr8 with CYP7A1, CYP7B1 (16 Mb region)

71 moss P450s with 48 additional plant sequences

Physcomitrella patens

Some things that seem impossible

may actually be possible

I’ll try anything once,

twice if I like it,

three times to make sure.