flutamide

11
Prepare by The pharmacist Ayia Nazum Kamal

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Page 1: Flutamide

Prepare by

The pharmacist Ayia Nazum Kamal

Page 2: Flutamide

•Capsules:Capsules: 125 mg ,250mg

Page 3: Flutamide

Flutamide is nonsteroidal antiandrogen )anti-Flutamide is nonsteroidal antiandrogen )anti-) testosterone) testosterone inhibits androgen uptake or inhibits nuclear inhibits androgen uptake or inhibits nuclear binding of androgen in target tissues or binding of androgen in target tissues or.both.both

Page 4: Flutamide

The t1/2 is about 6 h )active.)metabolite

drug is excreted primarily in theurine with 4.2% excreted in feces

Elimination

Flutamide is rapidly and extensivelymetabolized to at least 6 metabolites . The active metabolite ishydroxyflutamide.

Metabolism

parent drug:94% to 96%Active metabolite:92% to 94%

proteinbinding

Oral: rapid and complete Absorption

Page 5: Flutamide

-1 Metastatic prostate cancer, combinationtherapy with a luteinizing hormone- releasing hormone )LHRH( analog )eg,.)goserelin, leuprolide-2Treatment of hirsutism in women

-3 Juvenile Nasopharyngeal Angiofibroma flutamide was reported to reduce stage I and.II tumors to 44%

Page 6: Flutamide

Prostate carcinoma:* 250mg 3 times daily )for a total daily dose of 750)mg

Female hirsutism )unlabeled*use(:250mg daily

Page 7: Flutamide

-1-1 hypersensivity to flutamide or any.. component of the formulation

_2_2..severe hepatic function impairment

-3-3pregnancy..

Page 8: Flutamide

GIGI Low potential for nausea and vomiting; diarrhea; hepatocellular necrosis;cholestatic jaundice; elevated LFTsEndocrineEndocrineHot flashes, gynecomastia

GenitourinaryGenitourinary Impotence; reduced sperm countCNSCNSDecreased libido

Page 9: Flutamide

* cardiac disease)oedema reported(. * hepatic impairment, also liver function tests, monthly for first 4 months, periodically thereafter and at the first sign or symptom ofliver disorder )e.g . pruritus, dark urine, persistent anorexia, jaundice, abdominalpain, unexplained influenza-like symptoms)

Page 10: Flutamide

Drug InteractionsDrug Interactions Prothrombin time may increase when flutamide therapy is initiated in patients.stabilized on chronic warfarin therapyLaboratory Test InteractionsLaboratory Test Interactions Elevated AST, ALT, bilirubin, BUN, andserum creatinine

Page 11: Flutamide

The urine was noted to change to an*The urine was noted to change to an*amber or yellowamber or yellow--green appearancegreen appearance Photosensitization may occurPhotosensitization may occur* *

Flutamide and LHRH*Flutamide and LHRH*-- agonists should be agonists should beadministered concomitantlyadministered concomitantly