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Dr Aditya B Pant CSIR-IITR, Lucknow-India

Curriculum Vitae

Dr AB PantPhD, FATS, FST, FIAN, FAsAW, FAEB, MNASc, MAMS Principal Scientist System Toxicology & Health Risk Assessment GroupCSIR-Indian Institute of Toxicology ResearchVishvigyan Bhavan, 31, Mahatma Gandhi MargP.O. Box No. 80, Lucknow-226 001Uttar Pradesh, IndiaVoice: +91-522-2627586, 2620107, 2620207, 2614118 Ext: 321 (Office) +91-9935044044 (Personal)FAX: +91-522-2628227 Email: [email protected], [email protected], [email protected] Webpage: http://www.iitrindia.org/Admin%20Panel/Profile.aspx?id=55Pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pant+ABEditorial Member: Scientific Report- (Nature Publishing Group) Academic Editor: PLoS ONE (Largest online Journal)Editorial Advisor: Toxicology Research (Royal Society of Chemistry) Executive Editor: Journal of Clinical ToxicologyNational GLP Inspector: NGCMA, DST, Govt. of IndiaSecretary General: Society of Toxicology, India (2010-2014)

1. Date and Place of Birth : 05.12.1968/ Dehradun-Uttarakhand(Place was in Uttar Pradesh till November 8, 2000)

2. Present Position : Principal Scientist

3. Address (Office) : System Toxicology & Health Risk assessment Group CSIR-Indian Institute of Toxicology ResearchVishvigyan Bhavan, 31, Mahatma Gandhi Marg, P.O. Box No. 80, Lucknow-226 001Uttar Pradesh, India.Phone: 0522- 2627586 Ext: 321 (Office) 09935044044 (Personal)FAX: 0522-2628227 Email: [email protected], [email protected], [email protected]

Address (Residence) : D-3/49, Sushant Golf City, Sultanpur Road, Lucknow-226002, Uttar Pradesh, IndiaVoice: 09935044044

4. Academic qualifications : MSc (Microbiology), PhD (Biotechnology)

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mailto:[email protected]




http://www.iitrindia.org/Admin%20Panel/Profile.aspx?id=55




5. Positions, jobs and assignments held:

0BDurationPosition Held Organization

Nov. 2012- till date Principal Scientist

CSIR-Indian Institute of Toxicology Research, Lucknow (UP)

Nov. 2008- Nov. 2012 Sr. Scientist CSIR-Indian Institute of Toxicology Research, Lucknow (UP)

Nov. 2004- Nov. 2008 Scientist-C Indian Institute of Toxicology Research, Lucknow (UP)

Nov. 2001- Nov. 2004 Scientist-B Indian Institute of Toxicology Research, Lucknow (UP)

Nov.2003- July 2006 Guest Faculty Deptt. of Biochemistry, Lucknow University, Lucknow

6. Current area of research: (Give particulars in not more than 100 words)Applicability of plasticity and pluripotency potential of stem cells derived from human cord blood:

to develop human brain specific high throughput screening tool to assess the neurotoxicity and developmental neurotoxicity potential of drugs/ chemicals

to identify the stage specific early markers of injury and repair for developing human brain

to develop low density genome/proteome array as biomarkers to characterize the stage specific landmarks to assess the chemical/drug induced developmental neurotoxicity

to develop in vitro organ specific universal gene chip as predictive tool to identify the toxic potential of drugs/ chemicals at organ level in one go

7. List of selected publications in indexed journals: (As desired, the reprints of three publications have attached-Annexure-I).

Pubmed Link: http://www.ncbi.nlm.nih.gov/pubmed?term=Pant%20AB

Web page: http://www.iitrindia.org/Admin%20Panel/Profile.aspx?id=55

Total research papers: 143

Paper presented in symposia/ conferences: 190

Invited Lectures delivered: 166

Book Chapters written: 7

Cyber Lectures delivered: 4

Copyright Granted: 1

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http://www.ncbi.nlm.nih.gov/pubmed?term=Pant%20AB


1. S Jahan, S Singh, A Srivastava, V Kumar, D Kumar, A Pandey, CS Rajpurohit, AR Purohit, VK Khanna, AB Pant. (2017). PKA-GSK3β and β-Catenin Signaling Play a Critical Role in Trans-Resveratrol Mediated Neuronal Differentiation in Human Cord Blood Stem Cells. Molecular Neurobiology, doi: 10.1007/s12035-017-0539-x [Impact Factor: 6.19]

2. S Jahan, D Kumar, A Kumar, CS Rajpurohit, S Singh, A Srivastava, A Pandey, AB Pant. (2017). Neurotrophic factor mediated neuronal differentiation of human cord blood mesenchymal stem cells and their applicability to assess the developmental neurotoxicity. Biochemical and Biophysical Research Communications. 2017 Jan 22;482(4):961-967. [Impact Factor = 2.37]

3. AK Gupta, K Varshney, V Kumar, K Srivastava, AB Pant, SK Puri, AK Saxena. (2017). Design, synthesis, and biological evaluation of novel 1,2,4-Trioxanes as potential anti-malarial agents. Archiv der Pharmazie. 2017;350(3-4). [Impact Factor- 2.04]

4. M Kumari, L Ray, MP Purohit, S Patnaik, AB Pant, Y Shukla, P Kumar, KC Gupta. (2017). Curcumin-loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. European Journal of Pharmaceutics and Biopharmaceutics. 2017:S0939-6411(16)30437-4. [Epub ahead of print] [Impact Factor- 4.16]

5. YK Dhuriya, P Srivastava, RK Shukla, R Gupta, D Singh, D Parmar, AB Pant, VK Khanna. (2017). Prenatal exposure to lambda-cyhalothrin alters brain dopaminergic signaling in developing rats. Toxicology. 2017;386:49-59. [Epub ahead of print]. [Impact Factor- 3.82]

6. YK Dhuriya, P Srivastava, RK Shukla, R Gupta, D Singh, D Parmar, AB Pant, VK Khanna. (2017). Prenatal exposure to lambda-cyhalothrin impairs memory in developing rats: Role of NMDA receptor induced post-synaptic signalling in hippocampus. Neurotoxicology. 2017;62:80-91. [Epub ahead of print]. [Impact Factor- 3.10]

7. Srivastava P, Dhuriya YK, Gupta R, Shukla RK, Yadav RS, Dwivedi HN, Pant AB, Khanna VK. (2016). Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum. Molecular Neurobiology. 2016 December 13 [Epub ahead of print] [Impact Factor = 5.471]

8. SK Rajput, AK Sharma, CL Meena, AB Pant, R Jain, SS Sharma. (2016). Effect of L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 against in-vitro and in-vivo models of cerebral ischemia and associated neurological disorders. Biomedicine & Pharmacotherapy. 2016 Dec;84:1256-1265. [Impact Factor = 2.32]

9. A Jauhari, T Singh, A Pandey, P Singh, N Singh, AK Srivastava, AB Pant, D Parmar, S Yadav. (2016). Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence. Molecular Neurobiology. 2016 August 15 [Epub ahead of print] [Impact Factor = 5.471]

10. RK Shukla, YK Dhuriya, LP Chandravanshi, R Gupta, P Srivastava, AB Pant, A Kumar, CM Pandey, MH Siddiqui, VK Khanna. (2016). Influence of immobilization and forced swim stress on the neurotoxicity of lambda-cyhalothrin in rats: Effect on brain biogenic amines and BBB permeability. NeuroToxicology. 2016 Jul 7. pii: S0161-813X(16)30120-6. doi: 10.1016/j.neuro.2016.07.002. [Epub ahead of print] [Impact Factor = 2.73]

11. P Sharma, O Prakash, A Shukla, CS Rajpurohit, PG Vasudev, S Luqman, SK Srivastava, AB Pant, F Khan. (2016). Structure-Activity Relationship Studies on Holy

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https://www.ncbi.nlm.nih.gov/pubmed/27396915






http://www.sciencedirect.com/science/journal/07533322







https://www.journals.elsevier.com/biochemical-and-biophysical-research-communications




Basil (Ocimum sanctum L.) Based Flavonoid Orientin and its Analogue for Cytotoxic Activity in Liver Cancer Cell Line HepG2. Combinatorial Chemistry & High Throughput Screening. 2016;19(8):656-666. [Impact Factor = 1.04]

12. R Gupta, RK Shukla, LP Chandravanshi, P Srivastava, YK Dhuriya, J Shanker, MP Singh, AB Pant , VK Khanna. (2016). Protective Role of Quercetin in Cadmium-Induced Cholinergic Dysfunctions in Rat Brain by Modulating Mitochondrial Integrity and MAP Kinase Signaling. Molecular Neurobiology. 2016 July 7 [Epub ahead of print] [Impact Factor = 5.471]

13. P Bhatnagar, AB Pant, Y Shukla, A Panda, KC Gupta (2016). Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma. European Journal of Pharmaceutics and Biopharmaceutics. 2016: 105:176-192. [Impact Factor = 5.471]

14. V Kumar, A Pandey, S Jahan, RK Shukla, D Kumar, A Srivastava1, S Singh, CS Rajpurohit, S Yadav, VK Khanna, AB Pant. (2016). Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis. Scientific Reports. 2016: 6:28142. DOI:10.1038/srep28142. [Impact Factor = 5.578]

15. A Srivastava, V Kumar, A Pandey, S Jahan, D Kumar, CS Rajpurohit, S Singh, VK Khanna, AB Pant. (2016). Adoptive autophagy activation: a much-needed remedy against chemical induced neurotoxicity/ developmental neurotoxicity. Molecular Neurobiology. 2016 [Epub ahead of print] [Impact Factor = 5.471]

16. D Chopra, L Ray, A Dwivedi, SK Tiwari, J Singh, KP Singh, HN Kushwaha, S Jahan, A Pandey, SK Gupta, RK Chaturvedi, AB Pant, RS Ray, KC Gupta. (2016). Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. Biomaterials. 2016:84;25-41 [Impact Factor = 8.557]

17. RK Shukla, R Gupta, P Srivastava, YK Dhuriya, A Singh, LP Chandravanshi, A Kumar, MH Siddiqui, D Parmar, AB Pant, VK Khanna. (2016). Brain cholinergic alterations in rats subjected to repeated immobilization or forced swim stress on lambda-cyhalothrin exposure. Neurochemistry International. 2016;93:51-63. [Impact Factor = 2.920]

18. S Singh, A Srivastava, V Kumar, A Pandey, D Kumar, CS Rajpurohit, VK Khanna, S Yadav, AB Pant. (2015) Stem Cells in Neurotoxicology/Developmental Neurotoxicology: Current Scenario and Future Prospects. Molecular Neurobiology. 2015. [Epub ahead of print] [Impact Factor = 5.471]

19. V Kumar, AK Gupta, RK Shukla, VK Tripathi, S Jahan, A Pandey, A Srivastava, M Agrawal, S Yadav, VK Khanna, AB Pant. (2015) Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity. Scientific Reports. 2015:15;5:14038. [Impact Factor = 5.578]

20. P Srivastava, A Tiwari, AC Trivedi, V Thakur, AB Pant, S Saxena. (2015). Virtual Screening of Natural and Synthetic Ligands Against Diabetic Retinopathy by Molecular Interaction With Angiopoietin-2. Asia-Pacific Journal of Ophthalmology (Philadelphia) 2014:3(4):257-9.

21. S Yadav, A Jauhari, N Singh, T Singh, AK Srivastav, P Singh, AB Pant, D Parmar. (2015). MicroRNAs are Emerging as Most Potential Molecular Biomarkers. Biochemistry & Analytical Biochemistry. 2015:1;2015. [Impact Factor = 2.22]

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https://www.journals.elsevier.com/european-journal-of-pharmaceutics-and-biopharmaceutics/







http://www.eurekaselect.com/585/journal/combinatorial-chemistry-amp-high-throughput-screening

http://www.eurekaselect.com/585/journal/combinatorial-chemistry-amp-high-throughput-screening




22. AK Singh, S Tiwari, A Gupta, KK Shukla, KG Chhabra, A Pandey, AB Pant. (2015). Association of Resistin with Insulin Resistance and Factors of Metabolic Syndrome in North Indians. Indian Journal of Clinical Biochemistry. 2015;30(3):255-62. [Impact Factor = 2.191]

23. A Pandey, A Jauhari, T Singh, P Singh, N Singh, AK Srivastava, F Khan F, AB Pant, D Parmar, S Yadav. (2015). Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells. Toxicology Research. 2015;4(6):1578-86. [Impact Factor = 3.983]

24. P Bhatnagar, S Patnaik, AK Srivastava, MK Mudiam, Y Shukla, AK Panda, AB Pant, P Kumar, KC Gupta. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of Biomedical Nanotechnology. 2014 Dec;10(12):3558-75. [Impact Factor = 5.34]

25. A Pandey, P Singh, A Jauhari, T Singh, F Khan, AB Pant, D Parmar, S Yadav. (2015) Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. Journal of Neurochemistry. 2015;133(5):640-52 [Impact Factor = 4.244]

26. P Bhatnagar, AB Pant, Y Shukla, B Chaudhari, P Kumar, KC Gupta. (2015). Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model. European Journal of Pharmacology and Biopharmaceutics. 2015;91:35-46. [Impact Factor = 4.74]

27. V Kumar, S Jahan, S Singh, VK Khanna, AB Pant. (2015). Progress toward the development of in vitro model system for chemical-induced developmental neurotoxicity: potential applicability of stem cells. Archives of Toxicology. 2015:89(2):265-7. [Impact Factor = 5.078]

28. MA Siddiqui, Q Saquib, M Ahamed, NM Farshori, J Ahmad, R Wahab, ST Khan, HA Alhadlaq, J Musarrat, AA Al-Khedhairy, AB Pant. (2015). Molybdenum nanoparticles-induced cytotoxicity, oxidative stress, G2/M arrest, and DNA damage in mouse skin fibroblast cells (L929). Colloids and Surfaces B: Biointerfaces. 2015:1;125:73-81. [Impact Factor = 4.287]

29. V Kumar, VK Tripathi, S Jahan, M Agrawal, A Pandey, VK Khanna, AB Pant. (2015). Lead Intoxication Synergies of the Ethanol-Induced Toxic Responses in Neuronal Cells-PC12. Molecular Neurobiology. 2015:;52(3):1504-20. [Impact Factor = 5.286]

30. O Prakash, A Ahmad, VK Tripathi, S Tandon, AB Pant, F Khan. (2014). In silico assay development for screening of tetracyclic triterpenoids as anticancer agents against human breast cancer cell line MCF7. PLoS One. 2014:3;9(11):e111049. [Impact Factor = 3.534]

31. LP Chandravanshi, RK Shukla, S Sultana, AB Pant, VK Khanna. (2014). Early life arsenic exposure and brain dopaminergic alterations in rats. International Journal of Developmental Neuroscience. 2014;38:91-104. [Impact Factor = 2.918]

32. P Srivastava, RS Yadav, LP Chandravanshi, RK Shukla, YK Dhuriya, LK Chauhan, HN Dwivedi, AB Pant, VK Khanna. (2014).Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. Toxicology and Applied Pharmacology. 2014:15;279(3):428-40. [Impact Factor = 3.63]

33. MP Kashyap, V Kumar, AK Singh, VK Tripathi, S Jahan, A Pandey, RK Srivastava, VK Khanna, AB Pant (2014). Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity. Molecular Neurobiology. 2015:51(2):791-807. [Impact Factor = 5.286 ]

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34. VK Tripathi, V Kumar, AK Singh, MP Kashyap, S Jahan, A Pandey, S Alam, F Khan, VK Khanna, S Yadav, M Lohani, AB Pant. (2014). Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells. PLoS One.2014:9(3):e91946. [Impact Factor = 3.534 ]

35. LP Chandravanshi, RS Yadav, RK Shukla, A Singh, S Sultana, AB Pant, D Parmar, VK Khanna. (2014). Reversibility of changes in brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure. International Journal of Developmental Neuroscience. 2014:34:60-75[Impact Factor = 2.918]

36. DK Yadav, K Kalani, AK Singh, F Khan, SK Srivastava, AB Pant (2014). Design, synthesis and in vitro evaluation of 18β-glycyrrhetinic Acid derivatives for anticancer activity against human breast cancer cell line mcf-7. Current Medical Chemistry. 2014:21(9):1160-70. [Impact Factor = 3.715]

37. T Singh, A Jauhari, A Pandey, P Singh, AB Pant, D Parmar, S Yadav (2014). Regulatory triangle of neurodegeneration, adult neurogenesis and microRNAs. CNS & Neurological Disorders - Drug Targets. 2014:13(1):96-103. [Impact Factor = 2.702]

38. AK Singh, MP Kashyap, V Kumar, VK Tripathi, DK Yadav, F Khan, S Jahan, VK Khanna, S Yadav, AB Pant (2013). 3-Methylcholanthrene Induces Neurotoxicity in Developing Neurons Derived from Human CD34+Thy1+ Stem Cells by Activation of Aryl Hydrocarbon Receptor. Neuro-Molecular Medicine. 2013:15(3):570-92 [Impact Factor = 5.00]

39. N Pant, AB Pant, PK Chaturvedi, M Shukla, N Mathur, YK Gupta, DK Saxena (2013). Semen quality of environmentally exposed human population: the toxicological consequence. Environmental Science and Pollution Research. 2013:20(11):8274-81. [Impact Factor = 2.757]

40. SK Gupta, P Saxena, VA Pant, AB Pant (2012). Adhesion and biologic behavior of human periodontal fibroblast cells to resin ionomer Geristore: a comparative analysis. Dental Traumatology. 2013:29(5):389-93. [Impact Factor = 1.204]

41. M Harjai, J Bogra, M Kohli, AB Pant (2013). Suppression of apoptosis a new therapeutic target in sepsis? Anesthesia & Intensive Care Medicine. 2013:41(2):175-83. [Impact Factor = 1.47]

42. SO Abarikwu, EO Farombi, AB Pant (2013). Quercetin decreases steroidogenic enzyme activity, NF-κB expression, and oxidative stress in cultured Leydig cells exposed to atrazine. Molecular and Cellular Biochemistry. 2013;373(1-2):19-28. [Impact Factor = 2.388 ]

43. RK Srivastava, Q Rahman, MP Kashyap, AK Singh, G Jain, S Jahan, M Lohani, M Lantow, AB Pant (2012). Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Human & Experimental Toxicology. 2013;32(2):153-66. [Impact Factor = 1.772]

44. SO Abarikwu, AB Pant, EO Farombi (2012). Effects of quercetin on mRNA expression of steroidogenesis genes in primary cultures of Leydig cells treated with atrazine. Toxicology in Vitro. 2013;700-707. [Impact Factor = 3.207]

45. M Agrawal, V Kumar, MP Kashyap, VK Khanna, MA Siddiqui, AB Pant. (2012). trans-Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes. ACS Chemical Neuroscience. October 28, 2012: 285-294. [Impact Factor = 4.21]

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46. SK Gupta, P Saxena, VA Pant, AB Pant (2012). Release of toxicity of dental resion composites. Toxicology International. 2012; 19(3): 225-234. [Impact Factor = 1.233]

47. SO Abarikwu, AB Pant, EO Farombi (2012). Dietary antioxidant, quercetin, protects sertoli-germ cell coculture from atrazine-induced oxidative damage. Journal of Biochemical and Molecular Toxicology. 2012;26(11):477-85. [Impact Factor = 1.596]

48. MP Kashyap, AK Singh, V Kumar, DK Yadav, F Khan, S Jahan, VK Khanna, S Yadav, AB Pant.(2012). Pkb/Akt1 Mediates Wnt/GSK3β/β-Catenin Signaling-Induced Apoptosis in Human Cord Blood Stem Cells Exposed to Organophosphate Pesticide Monocrotophos. Stem Cells and Development. 2012:22;224-238. [Impact Factor = 4.67]

49. U Prasad, G Singh, AB Pant (2012). A dynamic human health risk assessment system. Toxicology International. 2012;19(2):195-200. [Impact Factor = 1.346]

50. AK Singh, MP Kashyap, S Jahan, V Kumar, VK Tripathi, MA Siddiqui, S Yadav, VK Khanna, V Das, SK Jain, AB Pant (2012). Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD 34 (+) stem cell-derived differentiating neuronal cells. Toxicological Sciences. 2012;129(2):392-410. [Impact Factor = 5.02]

51. SO Abarikwu, EO Farombi, AB Pant (2012). Kolaviron biflavanoids of Garcinia kola seeds protect atrazine-induced cytotoxicity in primary cultures of rat Leydig cells. International Journal of Toxicology. 2012;31(4):407-15. [Impact Factor = 4.328]

52. AK Singh, S Tiwari, A Gupta, SM Natu, B Mittal, AB Pant (2012). Association of resistin with metabolic syndrome in Indian subjects. Metabolic Syndrome and Related Disorders. 2012;10(4):286-91. [Impact Factor = 1.652]

53. SK Tripathi, R Goyal, MP Kashyap, AB Pant, W Haq, P Kumar, KC Gupta (2012). Depolymerized chitosans functionalized with bPEI as carriers of nucleic acids and tuftsin-tethered conjugate for macrophage targeting. Biomaterials. 2012:33(16):4204-19. [Impact Factor = 7.604]

54. SO Abarikwu, AB Pant, EO Farombi (2012). The protective effects of quercetin on the cytotoxicity of atrazine on rat Sertoli-germ cell co-culture. International Journal of Andrology. 2012 Aug; 35 (4):590-600. [Impact Factor = 3.565]

55. RW Ansari, RK Shukla, RS Yadav, K Seth, AB Pant, D Singh, AK Agrawal, F Islam, VK Khanna (2012). Involvement of dopaminergic and serotonergic systems in the neurobehavioral toxicity of lambda-cyhalothrin in developing rats. Toxicology Letters. 2012; 20; 211(1):1-9. [Impact Factor = 3.145]

56. RW Ansari, RK Shukla, RS Yadav, K Seth, AB Pant, D Singh, AK Agrawal, F Islam, VK Khanna (2012). Cholinergic dysfunctions and enhanced oxidative stress in the neurobehavioral toxicity of lambda-cyhalothrin in developing rats. Neurotoxicity Research. 2012;22(4):292-309. [Impact Factor = 3.514]

57. MA Siddiqui, V Kumar, MP Kashyap, M Agarwal, AK Singh, VK Khanna, J Musarrat,J Jahan and AB Pant (2012). Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells. Human & Experimental Toxicology. 2012;31(4):336-45. [Impact Factor = 1.73]

58. SO Abarikwu, AB Pant, EO Farombi (2012). 4-Hydroxynonenal induces mitochondrial-mediated apoptosis and oxidative stress in SH-SY5Y human neuronal cells. Basic and Clinical Pharmacology and Toxicology.2012;110(5):441-810. [Impact Factor = 2.179]

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59. ML Sankhwar, RS Yadav, RK Shukla, AB Pant, D Singh, D Parmar, VK Khanna. (2012). Impaired cholinergic mechanisms following exposure to monocrotophos in young rats. Human Experimental Toxicology. 2012 Jun; 31(6):606-16. [Impact Factor = 1.73]

60. AB Pant (2011). Symposium on Safety and Risk-Assessment Approaches for Materials of Herbal Origin: Managing Editor's Remarks. Toxicology International. 2011:18(1):S1-2. [Impact Factor = 1.346]

61. RK Srivastav, Q Rahman, MP Kashyap, M Lohani and AB Pant (2011). Ameliorative effects of dimetylthiourea and N-acetylcysteine on nanoparticles induced cyto-genotoxicity in human lung cancer cell line-A549. PLoS One. 6(9):e25767 [Impact Factor = 4.092]

62. V Gupta, AK Singh, V Gupta, S Kumar, N Srivastava, T Jafar, AB Pant (2011). Association of circulating resistin with metabolic risk factors in Indian females having metabolic syndrome. Toxicology International. 2011:8(2):168-72. [Impact Factor =1.453]

63. S Saxena, VK Khanna, AB Pant, CH Meyer, VK Singh (2011). Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. Pathobiology.2011: 78(5):261-5. [Impact Factor =1.948]

64. S Yadav, A Pandey, A Shukla, SS Talwelkar, A Kumar, AB Pant, D Parmar (2011). MiR-497 and miR-302b regulate ethanol induced neuronal cell death through BCL2 and cyclin D2. Journal of Biological Chemistry. 286(43):37347-57. [Impact Factor = 5.33 ]

65. RS Yadav, LP Chandravanshi, RK Shukla, ML Sankhwar, RW Ansari, PK Shukla, AB Pant, VK Khanna (2011). Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats. Neurotoxicology. 201;32(6):760-8. [Impact Factor = 3.09]

66. A Gupta, V Gupta, AK Singh, S Tiwari1, S Agrawal, SM Natu, CG Agrawal, MPS Negi and AB Pant (2011). Interleukin-6 G-174C gene polymorphism and serum resistin levels in north Indian women: potential risk of metabolic syndrome. Human and Experimental Toxicology. 30(10):1445-53. [Impact Factor = 1.772]

67. SO Abarikwu, EO Farombi, MP Kashyap, AB Pant (2011). Atrazine induces transcriptional changes in marker genes associated with steroidogenesis in primary cultures of rat Leydig cells. Toxicology In Vitro. 25(8):1588-95. [Impact Factor = 2.78]

68. SO Abarikwu, EO Farombi, MP Kashyap, AB Pant (2011). Kolaviron protects apoptotic cell death in PC12 cells exposed to Atrazine. Free Radical Research. 45(9):1061-73. [Impact Factor = 3.279]

69. MP Kashyap, AK Singh, V Kumar, VK Tripathi, RK Srivastava, M Agrawal, VK Khanna, S Yadav, SK Jain, AB Pant (2011). Monocrotophos induced apoptotic changes in PC12 cells: involvement of xenobiotic metabolizing cytochrome P450s. PLOs One. 6(3):e17757. [Impact Factor = 4.42]

70. SO Abarikwu, EO Farombi, AB Pant (2011). Biflavanone-kolaviron protects human dopaminergic SH-SY5Y cells against atrazine induced toxic insult. Toxicology In Vitro. 25(4):848-858. [Impact Factor = 2.78]

71. M Agrawal, V Kumar, MP Kashyap, VK Khanna, GS Randhawa, AB Pant (2011). Ischemic insult induced apoptotic changes in PC12 cells: Protection by trans resveratrol. European Journal of Pharmacology. 666(1-3):5-11[Impact Factor = 2.516]

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72. A Chandra, RK Srivastava, MP Kashyap, R Kumar, RN Srivastava, AB Pant (2011). The anti-inflammatory and antibacterial basis of human omental defense: selective expression of cytokines and antimicrobial peptides. PLoS One. 6(5):e20446. [Impact Factor = 4.42]

73. P Saxena, KK Wadhwani, MP Kashyap, SK Gupta and AB Pant (2011). Potential of the propolis as storage medium to preserve the viability of cultured human periodontal ligament cells attached to avulsed tooth: an in vitro study. Journal of Dental Traumatology. 27(2):102-128. [Impact Factor = 1.204]

74. SK Rajput, MA Siddiqui, V Kumar, CL Meena, AB Pant, R Jain, and SS Sharma (2011). Effect of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a Thyrotropin-Releasing Hormone Analog on Oxygen Glucose Deprivation, Glutamate and H2O2 induced cellular Injury. Peptides. 32(6):1225-1231. [Impact Factor = 2.654]

75. N Pant, AB Pant, M Shukla, N Mathur, YK Gupta and DK Saxena (2011). Environmental and experimental exposure of phthalate esters: The toxicological consequence on human sperm. Human and Experimental Toxicology. 30(6):507-14. [Impact Factor = 1.772]

76. A Verma, D Ali, M Farooq, AB Pant, RS Ray, RK Hans. (2011). Expression and inducibility of endosulfan metabolizing gene in Rhodococcus strain isolated from earthworm gut microflora for its application in bioremediation. Bio-resource Technology.102 (2011): 2979-2984 [Impact Factor = 4.98]

77. AB Pant (One of the Member of Indian Genome Variation Consortium) (2010). EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proceedings of National academy of Sciences (USA). 2; 107(44):18961-6. [Impact Factor = 9.737]

78. L.K. Dwivedi, P Sharma, R Singh, AB Pant (2010). Human health risk assessment and management of Indian population: an in-silico approach. Recent Research in Science and Technology. 2(6): 17-21 [Impact Factor = 0.619]

79. P Srivastava, AC Trivedi, A Tiwari, A Verma, AB Pant (2010). Phylogenetic analysis of poly and non structural protein in Japanese encephalitis virus with other related viral families. Annals of Neurosciences. 17(2): 74-79. [Impact Factor =4.68]

80. Saxena S, Pant AB, Khanna VK, Singh K, Shukla RK, Meyer CH, Singh VK (2010). Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-α therapy. Journal of Occupational Biology of Diseases Information. 3(1): 35-38. [Impact Factor = 1.136]

81. MP Kashyap, VK Khanna, VK Gupta, V Tripathi, VK Khanna and AB Pant (2010). Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells. Chemical Research in Toxicology. 23(11): 1663-1672. [Impact Factor = 4.19]

82. RK Srivastava, AB Pant, MP Kashyap, V Kumar, M Lohani and Q Rahman (2011). Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549. Nanotoxicology. 5(2):195-207. [Impact Factor = 7.844]

83. MA Siddiqui, G Singh, MP Kashyap, V Kumar, VK Tripathi, VK Khanna, S Yadav and AB Pant (2011). Effect of 4-hydroxynonenal on 6-hydroxydopamine exposed PC12 cells and protective potential of 17β-estradiol. Human and Experimental Toxicology. 30(8):860-869. [Impact Factor = 1.772]

84. MA Siddiqui, MP Kashyap, V Kumar, VK tripathi, VK Khanna, S Yadav and AB Pant (2011). Differential protection of pre-, co- and post-treatment of curcumin against

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hydrogen peroxide in PC12 Cells. Human and Experimental Toxicology. 30(3):192-198. [Impact Factor = 1.772]

85. RS Yadav, RK Shukla, ML Sankhwar, DK Patel, RW Ansari, AB Pant, F Islam and VK Khanna(2010). Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. Neurotoxicology.31(5):533-539. [Impact Factor = 3.09]

86. V Gupta, AK Singh and AB Pant (2010). Could resistin be a noble marker for metabolic syndrome? Journal of Metabolic Syndrome 4(4): 239-244. [Impact Factor =1.526]

87. RK Srivastava, M Lohani, AB Pant and Q Rahman (2010). Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: role of surface iron. Toxicology Industrial Health. 26(9): 575-82. [Impact Factor = 1.772]

88. MA Siddiqui, G Singh, MP Kashyap, VK Khanna, S Yadav and AB Pant (2010). Use of dopamine expressing PC12 cells for rotenone cytotoxicity assessment. Toxicology and Industrial Health 26(8): 533-42. [Impact Factor = 1.555]

89. M Ahamed, MA Siddiqui, MJ Akhtar, I Ahmad and AB Pant (2010). Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. Biochemical and Biophysical Research Communications 396:578–583. [Impact Factor = 2.60]

90. MA Siddiqui, MP Kashyap, VK Khanna, S Yadav and AB Pant (2010). Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells. Toxicology In Vitro 24: 1681-1688. [Impact Factor = 2.78]

91. MA Siddiqui, MP Kashyap, VK Khanna, S Yadav and AB Pant (2010). NGF induced differentiated PC-12 cells as in vitro tool to study the 4-hydroxynonenal induced cellular damages. Toxicology In Vitro 24: 1592–1598. [Impact Factor = 2.78]

92. RK Upreti, A Kannan and AB Pant (2010). Experimental impact of aspirin exposure on rat intestinal bacteria, epithelial cells and cell line. Human and Experimental Toxicology 29(10):833-43. [Impact Factor =1.772]

93. RS Yadav, ML Sankhwar, RK Shukla, AB Pant, R Chandra, F Islam and VK Khanna (2009). Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicology and Applied Pharmacology 240: 367-376. [Impact Factor =4.45]

94. GK Gupta, VK Gupta, P Shukla, AB Pant and PR Mishra (2009). Investigations on cellular interaction of polyelectrolyte based nano-walled reservoir using MCF-7 cell lines: a novel chemotherapeutic approach. Journal of Pharmacy and Pharmacology 61: 1601–1607. [Impact Factor = 2.033]

95. S Saxena, AB Pant, VK Khanna, AK Agarwal, K Singh, D Kumar and VK Singh (2009). Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in eales disease. Ocular Immunology & Inflammation 17(3): 201-206. [Impact Factor = 1.25]

96. V Jain, B Nath, GK Gupta, PP Shah, MA Siddiqui, AB Pant and PR Mishra (2009). Galactose-grafted chylomicron-mimicking emulsion: evaluation of specificity against HepG-2 and MCF-7 cell lines. Journal of Pharmacy and Pharmacology 61(3): 303-310. [Impact Factor = 2.175]

97. MP Kashyap, VK Gupta, V Tripathi, VK Khanna and AB Pant (2009). Human stem cells to assess the developmental neurotoxicity: monocrotophos induced changes in marker genes. Journal of Neurochemistry 109 (S1), 304. [Impact Factor = 4.061]

98. G Singh, MA Siddiqui, VK Khanna, MP Kashyap, S Yadav, YK Gupta, KK Pant and AB Pant (2009). Oxygen Glucose deprivation model of cerebral stroke in PC-12 cells:

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Glucose as a limiting factor. Toxicology Mechanism and Methods 19(1): 1-7. [Impact Factor = 2.175]

99. AB Pant (One of the Member of Indian Genome Variation Consortium) (2008). Genetic landscape of the people of India: a canvas for disease gene exploration. Journal of Genetics 87 (1): 3-20. . [Impact Factor =1.883]

100. MA Siddiqui, MP Kashyap, VK Khanna, VK Gupta, VK Tripathi, S Srivastava, and AB Pant (2008). Metabolism of 4-Hydroxy Trans 2- Nonenal (HNE) in Cultured PC-12 cells. Annals of Neurosciences 15: 60-68. . [Impact Factor = 11.089]

101. RK Upreti, A Kannan and AB Pant (2008). Alterations in rat gut bacteria and intestinal epithelial cells following experimental exposure of antimicrobials. FEMS Immunology and Medical Microbiology 54:60–69. [Impact Factor = 1.972]

102. MA Siddiqui, G Singh, MP Kashyap, S Yadav, VK Khanna, D Chandra and AB Pant (2008). Influence of cytotoxic doses of 4-hydroxynonenal on the expression of neurotransmitter receptors in PC-12 cells. Toxicology In Vitro 22(7): 1681-1688. [Impact Factor = 2.78]

103. N Tiwari, K Shukla, CS Ojha, AB Pant and VP Sharma. (2007). Cell Shocked. Current Science 44(1):10-14. [Impact Factor = 0.774]

104. N Kalra, K Seth, S Prasad, M Singh, AB Pant, Y Shukla (2007). Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life Sciences 80: 2137–2146. [Impact Factor = 2.583]

105. N Agarwal, RS Ray, AB Pant, and RK Hans. (2007). Development of in vitro model for the phototoxicity assessment of antibiotics of floroquinolone group. Photochemistry and Photobiology 83: 1226-1236. [Impact Factor = 5.36]

106. Raj K Upreti, A Kannan and AB Pant (2007). Experimental exposure of arsenic in cultured rat intestinal epithelial cells and cell line: Toxicological consequences. Toxicology In Vitro 21: 32-40. [Impact Factor = 3.321]

107. MA Siddiqui, G Singh, VK Khanna, MP Kashyap, S Yadav, D Chandra and AB Pant (2007). Oxidative stress mediated cellular responses in 4-Hydroxynonenal exposed PC12 cells. Ecophysiology and Occupational Health. (1&2):97-109.

108. MA Siddiqui, VK Khanna, G Singh, MP Kashyap, S Yadav, D Chandra and AB Pant (2007). Cytotoxic effects of 4-hydroxynonenal in PC12 cells: involvement of neurotransmitter receptors. Annals of Neurosciences.14: 85-92. [Impact Factor = 9.935]

109. S Yadav, VK Khanna, MA Siddiqui, M Kashyap and AB Pant (2007). Centromeric dysfunction/genotoxic effects in ethanol and lead co-exposed cultured human blood lymphocytes. Cellular Oncology 29:168. [Impact Factor = 3.175]

110. N Kapoor, AB Pant, A Dhawan, UN Dwivedi, PK Seth and D Parmar (2007). Differences in the expression and inducibility of cytochrome P4502B isoenzymes in cultured rat brain neuronal and glial cells. Molecular and Cellular Biochemistry 305:199-207. [Impact Factor = 1.764]

111. V Vishwanathan, Vinay K Khanna, AB Pant and PK Seth (2006). Structural and functional changes following ether exposure and oxidative stress. Annals of Neurosciences 14(1): 1-3. [Impact Factor = 9.935]

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112. AK Singh, V Gupta and AB Pant (2006). Resistin, is there any role in the mediation of obesity, insulin resistance and type-II diabetes mellitus? Journal of Physiology 7(1):43-46. [Impact Factor = 3.643]

113. S. Yadav, S. Geh, Q. Rahman and AB Pant (2006). Modulatory effects of garlic extract on chrysotile asbestos induced genotoxicity: An in vitro study. Bulletin of Environmental Contamination and Toxicology 77: 477-483. [Impact Factor = 0.609]

114. G Singh, M A Siddiqui, Y K Gupta, A K Saxena and A B Pant (2006). Oxidative stress, antioxidants and neurodegenerative disorders. Journal of Physiology 7 (1): 47-50. [Impact Factor = 3.643]

115. N. Kapoor, AB Pant, A Dhawan, UN Dwivedi, PK Seth and D Parmar (2006). Expression of cytochrome P450 1A1 in cultured rat brain neuronal and glial cells. Life Sciences 79 (25): 2387-2394. [Impact Factor = 2.583]

116. N Kapoor, AB Pant, A Dhawan, UN Dwivedi, YK Gupta, PK Seth and D Parmar (2006) Expression of cytochrome P450 2E1 in cultured rat brain neuronal and glial cells. Life Sciences 79(16): 1514-1522. [Impact Factor = 2.583]

117. Seema Briyal, AB Pant, YK Gupta (2006). Protective effect of endothelin antagonist (TAK-044) on neuronal cell viability in in vitro oxygen-glucose deprivation model of stroke. Journal of Physiology and Pharmacology 50 (2): 157-162. [Impact Factor = 2.631]

118. MK Pandey, AB Pant and Mukul Das (2006). Development of In vitro model system to evaluate the cytotoxic potential of polycyclic aromatic hydrocarbons mixture in RFFO. Toxicology In Vitro 20 (3), 308-316. [Impact Factor = 2.78]

119. VA Pant, VP Sharma and AB Pant (2005). In Vitro modulation in biological behaviour of cultured human periodontally related cells by platelet-rich plasma. Ecophysiology and Occupational Health. 5(2) 175-183.

120. VA Pant, VP Sharma, AK Agarwal and AB Pant (2005). Cell viability evaluation of cultured periodontal ligament fibroblasts in different readily available storage media. Journal of Ecophysiology and Occupational Health. 5(I); 113-121.

121. VA Pant, Jaya Dixit, AK Agarwal, PK Seth and AB Pant (2004). Behaviour of human periodontal ligament cells on CO2 laser irradiated dentinal root surfaces: An In vitro study. Journal of Periodontal Research 39; 373-379. [Impact Factor = 2.038]

122. N. Kapoor, AB Pant, D Parmar, UN Dwivedi, A Dhawan and PK Seth (2004). Evidence for expression of CYP2B in cultured rat brain neuronal and glial cells. Journal of Neurochemistry, p 68: 88 (S-1). [Impact Factor = 4.5]

123. N Kapoor, AB Pant, D Parmar, UN Dwivedi, A Dhawan and PK Seth (2003). Expression of cytochrome P450s in cultured rat brain cells. Journal of Neurochemistry, p 52:87 (S-1). [Impact Factor = 4.45]

124. AB Pant , AK Agrawal, VP Sharma and PK Seth (2001). In vitro cytotoxicity evaluation of plastic biomedical devices. Human & Experimental Toxicology. 20 (8), 412-417. [Impact Factor = 1.456]

125. VP Sharma, AB Pant and PK Seth (1999). In vivo safety evaluation of plastic biomedical devices for biological health hazards. Proceedings of Academy of Environmental Biology. 8:59. [Impact Factor = 0.041]

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126. AB Pant and GD Sharma (1999). Almar blue reduction: In vitro cytotoxicity assay for primary hepatocyte culture. Journal of Basic Applied Biomedicine. 7(3)167-169. [Impact Factor =1.629]

127. AB Pant (1999) Purification of heat stable enterotoxin of Escherichia coli: A toxoid antidiarrheal vaccine. Journal of Nature Conservation. 11(1):83-89. [Impact Factor = 1.629 ]

128. Khan RH and AB Pant (1998). In vitro detection of sporozoite-hepatocyte interaction by monoclonal antibody. Parasitology International, 47 (S-1) 360. [Impact Factor = 2.152]

129. AB Pant , VP Sharma and PK Seth (1998). 21ve sadi and peya jal samasya. In the proceedings of National symposium held at ITRC, Lucknow, from 27-28 February. pp. 98-102.

130. VP Sharma, AB Pant and PK Seth (1998). Plastic: Paryavaran and swasthya. In the proceedings of National symposium held at ITRC, Lucknow, from 27-28 February. pp. 42-45.

131. AB Pant and MA Rizvi (1998). Spontanious loss of R-plasmid among clinical isolates of Escherichia coli at 4oC. Journal of Nature Conservation. 10(2): 187-193. [Impact Factor =0.94]

132. AB Pant , RK Bedi and GS Randhwa (1998). Prevalance and transfer of R-plasmid in Escherichia coli isolates from healthy adults. International Veterinary Medical Journal 22(3):179-183. [Impact Factor = 0.725]

133. AB Pant and MA Rizvi (1998). Elimination of quinolone antibiotics carryover by use of antibiotic removal beads. Journal Basic Applied Biomedicine 6(2):15-18. [Impact Factor =1.629]

134. AB Pant and MA Rizvi (1997). Colonization factor antigen-I and enterotoxin production among somatic antigen group of Escherichia coli strains. Journal of Nature Conservation. 9(2): 121-125.

135. A Mishra, AB Pant, S Ramchandani, AK Rastogi, KK Kamboj and AK Balapure (1995). Plasmodium berghei induced alterations in the activity of adenosine triphosphatase and aryl hydrocarbon hydroxylase enzymes in liver explant culture. Journal of Parasitic Diseases. 19(2) 159-162.

136. A Mishra, AB Pant, S Ramchandani, AK Rastogi, KK Kamboj and AK Balapure (1995). Molecular changes in P.berghei infected mice liver explants and their responsiveness to insulin in culture. Journal of Parasitic Diseases. 19(1) 67.

137. AB Pant and GS Randhwa (1995). High level quinolone resistance in Escherichia coli isolates from healthy adults. Biotech Technology 9(7):512-525. [Impact Factor = 2.75]

138. AB Pant (1995). A new micrbroth dilution method for susceptibility testing of Escherichia coli isolates against routinely used antibiotics. Journal of Antimicrobial Chemotherapy, 34: 571-573. [Impact Factor = 3.95]

139. AB Pant , GS Randhwa, GD Sharma & MK Kapil. (1994). Plasmid elimination from clinical isolates of Escherichia coli by ciprofloxacin and other inhibitors of DNA gyrase. Biotech Technology 8(3): 209-213. [Impact Factor =2.16]

140. AB Pant , MK Kapil and Prachi Joshi (1994). Biological Treatment of Industrial effluents by certain hydrophytes. International Journal of Agriculture and Biological Research. 10(2): 12-21.

13


141. AB Pant , MK Kapil and Ashutosh Pant (1993). In vitro effect of seed, bark and leaf extract of Nyctanthes arbortritis on seed germination and early seedling growth of Parthenium hysterophorous Linn. International Journal of Agriculture and Biological Research. 9(1): 26-32.

142. DK Garg, AB Pant, Manju R Agarwal and RN Goel (1990). Seasonal variation in ground water quality in Roorkee city. International Journal of Environmental Protection. 10(9) 673-676.

143. DK Garg, RN Goel, VP Agarwal and AB Pant (1990). Correlation among water quality parameters of ground water in Roorkee city. International Journal of Environmental Protection. 10(5) 335.

8. List of patents taken: Copyright granted for the development of “Bio-calculators” for the rapid and precise

calculations of biological and statistical endpoints (No. 013/CR/2006/748854). These bio-calculators along with database management system on ‘human health risk assessment and management’ are available on dedicated website (http://www.healthriskindia.in) developed and designed by us and available for public use.

A novel oral formulation of Amphotericin B to treat visceral Leishmaniasis: A US patent is being filed jointly by CSIR-IITR and CSIR-IITR, Lucknow, where I am one of the investigators.

Details of commercialization of technologies developed: Bio-calculators and database management system developed by us are available for public

use free of cost through website (http://www.healthriskindia.in).

9 List of book Chapters written:

S. No.

Title Author’s Name Publisher Publication Year

1 Toxicological consequences of modulation of brain cytochrome P450s by environmental chemicals. Chapter in book entitled “Pharmacological Prospective of Soma Toxic Chemicals and Their Antidotes”.

D Parmar, S Yadav, A Johri, N Kapoor, AB Pant, A Dhawan and PK Seth

Narosa Publishing House, New Delhi

2004

2 Oxidative stress in macular disorder: strategies for management. A chapter in book entitled “Recent developments in ocular disorders”.

VK Khanna, AB Pant and S Saxena

Japyee Press, New Delhi

2007

3 Combinational antifungal therapy and recent trends in drug discovery. Chapter in book entitled “Combating fungal infections: problems and remedies”.

I Ahmad, MSA Khan, M Zahin, M Owais, Z Mehmood and AB Pant

Springer Press 2010

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http://www.healthriskindia.in/


4 In vitro approaches for biosafety of nanoparticles: strategies and points to ponder. Chapter in book entitled “Nanomaterials: Hazards Assessment”.

MP Kashyap, RK Srivastava, AK Singh, VK Khanna, AB Pant

Educational Book Centre, Mumbai

2012

5 Alternatives to the experimental animals in biomedical research and testing. Chapter in book entitled “Use of animals in scientific research and education”.

AB Pant and VK Khanna

Indian National Science Academy, New Delhi

2012

6 Status of toxicology in India. AB Pant Amity University, Lucknow

2012

7 Development of in vitro toxicology: A historic story. Chapter in book entitled “In Vitro Toxicology”.

S Singh, VK Khanna and AB Pant

Published by Elsevier

2017

8 इन वि�ट्रो टॉक्सि�कोलॉजी का वि�का�: एक ऐवि�हासि�क �र्ण�न

पुनी� खरे, वि�नय कुमार खन्ना ए�ं आदि$त्य भूषर्ण पन्�

�ीए�आईआर-भार�ीय वि�षवि�ज्ञान अनु�ंधान

�ंस्थान, लखनऊ(उ.प्र.)

2017

10 Particulars of citation index of published work in national and international journals:

Pubmed Link: http://www.ncbi.nlm.nih.gov/pubmed?term=Pant%20AB

Web page: http://www.iitrindia.org/Admin%20Panel/Profile.aspx?id=55

11. Particulars of memberships in academic societies/ professional bodies: Fellow: Academy of Toxicological Sciences, USA (One among the only two Indians)

Fellow: Society of Toxicology, India

Fellow: Academy of Sciences for Animal Welfare, MoEF, Government of India

Fellow: Academy of Environmental Biology

Fellow: Indian Academy of Neurosciences

Member: National Academy of Sciences, India.

Member: National Academy of Medical Sciences, India

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http://www.ncbi.nlm.nih.gov/pubmed?term=Pant%20AB


Member: International Society for Stem Cell Research (ISSCR), USA

Member: Society of Toxicology, USA

Member: International Neurochemistry Society, USA

Member: European Society of Toxicology In Vitro

Member: Academy of Environmental Biology India

Member: Indian Academy of Neurosciences

Member: Indian Neurochemistry Society

Member: Laboratory Animal Scientist’s Association, India

Member: Environmental Mutagen Society, India

Member: Indian Pharmacology Society

Member: Advisory Board of Research & Executive Council of National Centre for Stem Cell Technology & Research UP, India

Member: Indian Society for Parasitology

Member: UP Association for Science & Technology Advancement, India

Member: Red Cross Society, Indian Chapter

Member: St. John Ambulance Association, Indian Chapter

12. Awards won

S.No. Name of Award Name of the awarding body Year

1. Vigyan Ratna Award-2010 Council of Science & Technology UP, Government of Uttar Pradesh, Lucknow

2010

2. STOX/ASAW Gold Medal Society of Toxicology, India 2011

3. Shakuntala Amir Chand Prize-2007

Indian Council of Medical Research, Government of India, New Delhi, India

2011

4. National Bioscience Award for Career Development-2012

Department of Biotechnology, Ministry of Science & Technology, Government of India

2013

5. AEB Gold Medal-2013 for Meritorious Service-2013

Academy of Environmental Biology, India

2013

6. Prof. KT Shetty Memorial Oration Award-2017

Indian Aacdemy of Neurosciences, India

2017

Research Fellows received awards, based on research work carried out under the supervision of Dr Pant (2008-2017):

Dr. Mahendra Pratap Kashyap received ‘Travel Award’ for poster presentation in the 8th

Biennial Meeting of the Asia-Pacific Society for Neurochemistry, held at Shanghai, PR China from June 23-26, 2008. Journal of Neurochemistry. 106 (S1), 43.

Mr. Rajesh Yadav received ‘Jyotsnamoyee Raghunath Bhattacharya Best Paper Award-2009’ for our paper “Attenuation of arsenic neurotoxicity by curcumin in rats” published in Toxicology and Applied Pharmacology. 2009; 240 (3):367-376, by Indian Academy of

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Neurosciences, India at its annual meeting held at NIMS University, Jaipur, India from December 18-20, 2009.

Mr. Mahendra Pratap Kashyap received ‘Jyotsnamoyee Raghunath Bhattacharya Best Paper Award-2011’ for our paper “Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells” published in Chemical Research in Toxicology. 2010; 23(11). 1663-1672, by Indian Academy of Neurosciences, India at its annual meeting held at DRDO, New Delhi, India from October 30- November 1, 2011.

Mr. Rajesh Yadav received ‘Molecular Chemoprevention and Therapeutics (MCT)-University of Minnesota Research Excellence Award’ for best poster presentation at the Annual Meeting of Society of Toxicology, India (STOX) during December 09 -11, 2010 at Jamia Hamdard, New Delhi, India.

Mr. Abhishek Kumar Singh received ‘Travel Award’ for poster presentation in the 23rd

Biennial Meeting of International Society for Neurochemistry (ISN) jointly with European Society for Neurochemistry (ESN) held at Athens, Greece during August 28 to September 1, 2011. Journal of Neurochemistry. 2011; 118 (S1):119.

Mr. Rajesh Yadav received ‘Travel Award’ for poster presentation in the 34th Annual Meeting of the Japan Neuroscience Society (JNS) held on September 14-17, 2011 at Yokohama, Japan. Neuroscience Research. 2011; 71 (S-1): e320.

Mr. Rajesh Yadav received ‘Professor R. Nath Memorial Travel Award’ for poster presentation in the XXIX Annual Meeting of Indian Academy of Neurosciences held at New Delhi from October 30-November 01, 2011.

Mr. Rajesh Yadav received ‘Congress Travel Award’ for poster presentation in the XIX World Congress on Parkinson’s disease and Related Disorders held at Shanghai, China from December 11-14, 2011. Parkinsonism and Related Disorders. 2012; 18 (S-2):S213–S214.

Mr. Abhishek Kumar Singh received ‘Travel Fellowship’ for excellent presentation at the 35th Annual Meeting of the Japan Neuroscience Society (JNS) held on September 17-21, 2012 at Nagoya, Japan.

Mr. Abhishek Kumar Singh received ‘International Travel Grant’ from Department of Science and Technology, Govt. of India, New Delhi, to presentation the research work in the 11th Biennial Meeting of Asian Pacific Society for Neurochemistry and 55th Annual Meeting of the Japanese Society for Neurochemistry held at Kobe, Japan from September 30-October 02, 2012. Journal of Neurochemistry.2012; 123(S-1):85.

Mr. Rajesh Yadav received ‘ISN-APSN-IBRO Travel Fellowship’ to attend ISN-APSN- IBRO School held at Osaka University School of Medicine and Nara Institute of Science and Technology, Osaka, Japan, from September 25-28, 2012.

Mr. Rajesh Yadav received ‘Best Student Poster Presentation Award’ at the 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and the 55th Annual Meeting of the Japanese Society for Neurochemistry held at Kobe, Japan from September 30-October 02, 2012. Journal of Neurochemistry.2012; 123(S-1):85.

Mr. Abhishek Kumar Singh received ‘ISN-APSN-IBRO Travel Fellowship’ at the 11 th

Biennial Meeting of the Asian Pacific Society for Neurochemistry and the 55 th Annual Meeting of the Japanese Society for Neurochemistry held at Kobe, Japan from September 30-October 02, 2012. Journal of Neurochemistry.2012; 123(S-1):85.

Mr. Rajesh Yadav received ‘Professor R. Nath Memorial Travel Award’ for poster presentation in the XXX Annual Meeting of Indian Academy of Neurosciences and

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International Symposium on Translational neuroscience: Unraveling the Mysteries of Brain in Health and Disease held at Amritsar, India from October 27-30, 2012. Annals of Neurosciences. 2012; 19(S-1):69.

Mr. Pranay Srivastava received ‘Tulsabai Somani Education Trust Award’ for best oral presentation during the XXX Annual conference of Indian Academy of Neurosciences and International Symposium on Translational neuroscience: Unraveling the Mysteries of Brain in Health and Disease held at Amritsar, India from October 27-30, 2012. Annals of Neurosciences. 2012; 19(S-1):32.

Mr. Vivek Kumar received ‘Best Poster Award’ in 32nd Annual Conference of Society of Toxicology (STOX), India and International Symposium on New Paradigms in Toxicology (NPT-2012) organized at CSIR-Indian Institute of Toxicology Research (IITR), Lucknow, India, from December 05-07, 2012.

Mr. Pranay Srivastava received ‘Best Poster Award’ in the XII Annual Meeting of the Society for Free Radical Research-India and International Symposium on Advances in Free Radicals, Redox Singling and Translational Antioxidant Research held at Lucknow, India, from January 30- February 01, 2013.

Mr. Rajendra Kumar Shukla received FAONS Student Travel Award to attend the FAONS Symposium 2013 in association with the 33rd annual meeting of the Australian Neuroscience Society (ANS 2013) held at Melbourne, Australia from February 3-6, 2013.

Mr. Abhishek Kumar Singh received ‘Best Poster Award’ in the 27th Annual Meeting of Society for Neurochemistry, India (SNCI-2013) held at All India Institute of Medical Sciences (AIIMS), New Delhi, India from February 20-23, 2013.

Mr. Abhishek Kumar Singh received ‘International Travel Grant’ from CSIR, Govt. of India, to present the research work in the 24th Biennial Meeting of Society for Neurochemistry being jointly organized with American Society for Neurochemistry (ASN-ISN 2013) at Cancun, Mexico from April 20-24, 2013.

Mr. Vinay Kumar Tripathi received ‘International Travel Fellowship’ to present the research work in the 24th Biennial Meeting of Society for Neurochemistry being jointly organized with American Society for Neurochemistry (ASN-ISN 2013) at Cancun, Mexico from April 20-24, 2013.

Mr. Vivek Kumar received ‘International Travel Fellowship’ to present the research work in the 24th Biennial Meeting of Society for Neurochemistry being jointly organized with American Society for Neurochemistry (ASN-ISN 2013) at Cancun, Mexico from April 20-24, 2013

Ms. Ankita Pandey received ‘International Travel Fellowship’ to present the research work in the 24th Biennial Meeting of Society for Neurochemistry being jointly organized with American Society for Neurochemistry (ASN-ISN 2013) at Cancun, Mexico from April 20-24, 2013.

Ms. Parul Singh received ‘International Travel Fellowship’ to present the research work in the 24th Biennial Meeting of Society for Neurochemistry being jointly organized with American Society for Neurochemistry (ASN-ISN 2013) at Cancun, Mexico from April 20-24, 2013.

Mr. Abhishek Jauhari received ‘ISN Travel Award’ to attend the 6th special conference of International Society of Neurochemistry at Tokyo, Japan from September 20-22, 2014.

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Mr. Pranay Srivastava received ‘Best Poster Presentation award’ at International Pharmaceutical Conference on Nano-formulation and Translational Research: Small getting Bigger at BBA University, Lucknow, India from February 2-3, 2015.

Mr. Rajendra Kumar Shukla received the Travel Award to attend the 38th Annual Meeting of the Japan Neuroscience Society, Kobe, Japan from July 28 – 31, 2015.

Ms. Tanisha Singh received “International Travel Award” for 25th ISN-APSN Joint Biennial Meeting at Cairns, Australia organized in conjunction with Australian Society of Neuroscience (ANS) from August 23-27, 2015.

Ms. Richa Gupta received ‘IBRO APRC Travel Award’ for IBRO/APRC Chandigarh School at Punjab University, Chandigarh, India from October 26-30, 2015.

Mr. Pranay Srivastava received ‘Congress Travel Award’ by the Melvin Yahr International Parkinson’s Disease Foundation and the International Association of Parkinsonism and Related Disorders to attend the XXI World Congress on Parkinson’s Disease and Related Disorders at Milan, Italy from 6-9 December, 2015.

Ms. Richa Gupta received ‘Congress Travel Award’ by the Melvin Yahr International Parkinson’s Disease Foundation and the International Association of Parkinsonism and Related Disorders to attend the XXI World Congress on Parkinson’s Disease and Related Disorders at Milan, Italy from 6-9 December, 2015.

Mr. Pranay Srivastava received ‘IBRO APRC Travel Award’ for IBRO/APRC Colombo School at Colombo, Sri Lanka from December 14-20, 2015.

Mr. Dipak Kumar was amongst the 16 shortlisted candidates from all over the world to attend 3rd AIST International Imaging Workshop organized at Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Science City, Japan from January 18-24, 2016.

Ms. Ankita Pandey received the “IBRO APRC Travel Fellowship” to attend the IBRO APRC School at National Brain Research Centre (NBRC), Manesar, Haryana from March 15-30, 2016.

Ms. Akriti Srivastava received the “Post Graduate Travel Award” to attend the 14th meeting of the Asian- Pacific Society for Neurochemistry (APSN) held at Kuala Lumpur, Malaysia from August 27-30, 2016.

Ms. Shripriya Singh received the first prize for the best oral presentation award at the IBRO/APRC Associate School of Neuroscience: ‘Dawn of the aging world-nipping neurodegeneration in the bud’, held at Selangor, Malaysia from August 8th-14th 2016.

Mr. Akriti Srivastava received Post Graduate Travel Award for attending the 14th Meeting of the Asia-Pacific Society for Neurochemistry (APSN) held from August 27-30, 2016 at Kuala Lumpur, Malaysia.

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Ms. Richa Gupta awarded World Parkinson’s Congress Travel Grant by World Parkinson’s Congress to present the research paper in 4th WPC2016, Portland, Oregon from September 20-24, 2016.

Mr. Chetan Singh Rajpurohit received best Poster Presentation award at XXXIV Annual Conference of the Indian Academy of Neurosciences held at National Brain Research Centre, Gurugram, India, during October 19-21, 2016.

Ms. Richa Gupta received best Poster Presentation award at XXXIV Annual Conference of the Indian Academy of Neurosciences held at National Brain Research Centre, Gurugram, India, during October 19-21, 2016.

Ms. Akriti Srivastava received Best Poster Award (1st runner-up) at 2nd IBRO/APRC Chandigarh School of Neuroscience held from December 14-22, 2016 at Panjab University, Chandigarh, Punjab.

Mr. Pranay Srivastava received Best Oral Presentation Award at 2nd IBRO/APRC Chandigarh School of Neuroscience at Panjab University, Chandigarh, Punjab from December 14-22, 2016.

Ms. Ankita Pandey received Best Poster Presentation Award in Indo-Russian Meet and Second International Conference on Biotechnological Advancements in Free Radical Biology and Medicine (ICBAFM) held at Integral University, Lucknow from January 23-25, 2017.

Mr. Chetan Singh Rajpurohit received the "IBRO/APRC Travel Grant" to attend the IBRO/APRC Associate School 2017 on “Computational approaches in Neuroprotection and Neurorehabilitation” held at Department of Biomedical Engineering, NEHU, Shillong, Meghalaya, India from June 05-10, 2017.

Ms. Richa Gupta received IBRO-APRC Travel Grant by IBRO to attend the IBRO/APRC Singapore associate School of Neuroscience, Singapore from July 03-07, 2017.

Ms. Richa Gupta awarded MDS International Travel Grant by Movement disorder society to attend the 21st International Congress of Parkinson’s Disease and Movement Disorders, June 4-8, 2017 in Vancouver, BC, Canada.

Ms. Shripriya Singh selected for the ISN Advanced School Travel Award to attend the 14th

ISN Advanced School entitled as "The Energetic Brain" to be held from 16-24 August, 2017 at Paris, France.

Mr. Chetan Singh Rajpurohit selected for ISN Travel Award to attend the International Society of Neurochemistry- European Society of Neurochemistry (ISN-ESN) Meeting to be held from 20-24 August, 2017 at Paris, France.

Ms. Richa Gupta selected for the ISN Advanced School Travel Award to attend the 14th

ISN Advanced School entitled as "The Energetic Brain" to be held from 16-24 August, 2017 at Paris, France.

Ms. Ankita Pandey selected for FENS Travel Award to attend FENS regional meeting to be held at Pecs, Hungary from 20-23rd September, 2017.

13. Recent foreign visits: S. No.

Place of visit Purpose Duration

1. Chulabhorn Research Institute To attend international training Nov 23-Dec 14,

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Bangkok, Thailand course on ‘Environmental and Health Risk Assessment and Management of Toxic Chemicals’

2016

14. Significant research contribution of last 10 years (not exceeding 300 words):In the scientific fraternity, I have been known for establishing the cell based in vitro models as alternatives to laboratory animals for neurotoxicity, developmental neurotoxicity, cytotoxicity, pyrogenicity, phototoxicity, hepatotoxicity, genotoxicity, oral-toxicity. I have been instrumental in establishing the laboratory for stem cell research in this part of the country and became renowned for my elegant research on application of human cord blood stem cells (hCBSCs) in developmental neurotoxicity (DNT). We have demonstrated the mapping of cellular and sub-cellular events of differentiation of hCBSCs into morphological and functional neuronal cells. We published our findings in journal “Stem Cells and Development” in 2012 and shared the volume of journal with Prof. Shinya Yamanaka and Prof. John B. Gurdon, the Nobel Laureates of 2012-Medicine and Physiology. The DNT research of mine provides deep insights into the complex processes involved in neuronal development, injury and repair mimicking to the human brain during the gestation and early stage of life. More precisely, my work discovered that how the master regulator signalling molecules/ cascades are critical to convert hCBSCs into functional neurons and what exactly happens when things go wrong during the intricate process of neuronal development. In our much-acclaimed research, we have uncovered novel links between the xenobiotic metabolizing capabilities and their regulators in hCBSCs derived neuronal cells all through the differentiation. Our work on the developing neurons not only offers a much sought after framework for understanding the neurodegenerative disorders and potential therapeutic interventions, but also is a strong base for future studies aimed at interpreting the human brain specific DNT. Besides the laboratory work, I dedicated myself to fostering the science among students through public outreach talks and mentoring pre and post-doctorates. Being GLP Inspector I was instrumental in getting India the status of full adherent OECD member country. Under my guidance, CSIR-IITR, Lucknow got the pride to be the first and only GLP certified laboratory in the entire CSIR. The accreditation agencies-NABL, BIS and DCGI are also utilizing my expertise. Taking my inputs Society of Toxicology, USA has developed a consensus document “Hooka: How dangerous is it?” for wide publicity. I have developed an online human health risk assessment system for Indian population-http://healthriskindia.in. I was a member in the draft committee of “National SOP for Patients’ Consent in India” developed by the Institute of Medicine & Law, Mumbai. As an International Advisor, I have been instrumental in establishing the “Centre of Excellence for Nanotechnology” at Makerere University, Uganda. Recently, I am culminating a task to address the challenges of a neglected neurodegenerative disorder-Amyotrophic Lateral Sclerosis by utilizing an investigator driven federal funding under Indo-Brazilian project. I am also holding editorial positions in several reputed journals such as Scientific Reports (Nature Publishing Group), PLoS-ONE, Toxicology Research (Royal Chemical Society), Journal of Clinical Toxicology, etc.

15. Any other information:(a) Research Impact:

In the year 2012, we published the data on differentiation mechanism(s) of stem cell derived human neurons in the journal “Stem Cells and Development”. We shared the volume of journal with Prof. Shinya Yamanaka and Prof. John B. Gurdon, the Nobel Laureates of 2012 (Medicine and Physiology).

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http://healthriskindia.in/


Our research work published in Chemical Research in Toxicology 23(11): 1663-1672; 2010 has been ranked number one (received 516 votes) in the list of hottest fifty papers published in 2010 in the entire range of journals published by the American Chemical Society (http://www.chemfeeds. com/hot.php?time=year).

The same paper has also been included in the final examination (December 16, 2010) of course designed for graduate and advanced undergraduate students in Environmental Sciences & Toxicology, and related disciplines at The North Carolina University of Chapel Hill, USA.

The paper has also been picked-up by several scientific news agencies to highlight the findings, for instance-http://www.newsrx. com/newsletters/Life-Science-Weekly/2011-01-11/2501112 011649LS.html.

One of our papers published in PLoS ONE:6(3):e17757;2011 has received overwhelming response among the scientists as evidenced by huge viewing and downloading of the article (over 5500).

Our twenty research papers have been included in the “Comparative Toxicogenomics Database” (CTD; http://ctdbase.org/) under “Chemical-Gene Interactions and Diseases". CTD is an NIEHS-funded public database that elucidates molecular mechanisms by which environmental chemicals affect the disease. It contains chemical-gene-disease interactions curated from the scientific literature.

We have been granted a copyright (No. 013/CR/2006/748854) for the development of “Bio-calculators” for the rapid and precise calculations of biological and statistical endpoints. Besides this, a dynamic ‘Online Human Health Risk Assessment System’ has also been developed for Indian population. Using this Online Health Information System, any individual can assess the health status and potential health risk by own. In addition to that, bioscience calculators related to the Statistical, Oxidative stress, Xenobiotic Markers, Food Technology and Statistically Analysis have also been uploaded to this online system to make the biological calculations accurate, easy and rapid. A wide range of information on various research organizations, scientific journals and many more features of this Online Information System may also be obtained through this system. This online system can be operated through our website- http://healthriskindia.in.

Being ‘National GLP Inspector’, I am providing my services to the National GLP Compliance Monitoring Authority, Department of Science & Technology, Ministry of Science & Technology, Government of India, for GLP accreditation and monitoring of the implementation of the OECD Principles of GLP in GLP Certified Laboratories in the country. Under my leadership, my research organization i.e., CSIR-Indian Institute of Toxicology Research, Lucknow-India, got a pride to be the first GLP Certified Laboratory among the 37 Laboratories of CSIR, India.

CSIR Focused Network-EMPOWER (CFN-EMPOWER) Projects under CSIR-WWW: My project proposal “Integrated gene chip to detect organ specific responses against xenobiotics in one go” (CSIR/WWW/IITR/101) was ranked number 1 in average rating i.e., 4.64/5.0; and ranked 6 out of the total 640 projects submitted in terms of ‘Most Discussed and Most Networked Project’. The project was shortlisted in 189 project proposals. The task had been finally short listed for possible funding.

(b) Technologies Developed:

Design and developed an online system to assess and manage the human health risk: A dynamic Online Human Health Risk Assessment System (OHHRAS) has been developed

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for Indian population. Using this Online Health Information System, any individual can assess the health status and potential health risk by own. In addition to that, bioscience calculators related to the Statistical, Oxidative stress, Xenobiotic Markers, Food Technology and Statistically Analysis have also been uploaded on this online system to make the biological calculations accurate, easy and rapid. A wide range of information on various research organizations, scientific journals and many more features of this Online Information System may also be obtained through this system. This online system can be operated through http://healthriskindia.in.

Developed Bio-calculators: Copyright granted for the development of “Bio-calculators” for the rapid and precise calculations of biological and statistical endpoints (No. 013/CR/2006/ 748854). These biocalculators along with database management system on ‘human health risk assessment and management’ are available on dedicated website (www.healthrisk.in) developed and designed by us and available for public use.

(c) Major R&D projects/ programmes implemented:

Research Grants received

Project Title Funding Agency

Amount (In Lacs)

Period

Extramural projects as Principal Investigator

In vitro model for evaluation of medical devices for biological hazards.

ICMR 5.00 Jan. 2000 to Jan. 03

Neuro-genotoxicity assessment of co exposure of lead and ethanol: an in vitro Study

ICMR 6.50 May 05- May 08

Development of in vitro models of cerebral stroke to evaluate neuroprotective effects of herbal drugs

ICMR 18.00 July 06 - July 09

Studies on the expression and regulation of xenobiotic metabolizing cytochrome P450s in human brain cells

CST-UP 5.50 July 07- July 10

Therapeutic interventions in oral sub-mucous fibrosis: an experimental study

ICMR 20.00 May 09- May 12

Development of monoclonal antibody based ELISA/Dip stick kits for GM food and crops

DBT 53.00 Oct. 08 - Oct. 11

Functional neuronal differentiation of human cord blood stem cells: tool to study the chemical induced developmental neurotoxicity

DBT 54.00 Nov. 2010- Oct 13

Functional characterization of brain cytochrome P450s in differentiating neuronal and glial cells - derived from human umbilical cord blood stem cells

DST 65.00 May 2012- May 15

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Dissecting the signaling cascade involved in Trans-Resveratrol induced neuronal differentiation in PC12 cells: implications in neurodegenerative disorders (Project received under National Bioscience Award for Career Developemnt-2012)

DBT 9.00 Aug. 2013-Aug. 16

Human cord blood stem cells derived 3D neuronal network: mechanistic understanding of chemical induced developmental neurotoxicity and neuroprotection (Approved but funds yet to receive)

ICMR 92.00 2017-2020

Application of human iPSCs in deciphering the cellular and molecular mechanisms of amyotrophic lateral sclerosis and disease association with developmental neurotoxicity

Indo-Brazil (DBT)

168.00 June 2016-May2020

Extramural projects as Co-Principal Investigator

Clinical trial with RISUG: genotoxicity and mutagenicity studies

ICMR 8.00 April 05-March 06

Cytokine profile in Eales’ disease: relationship with disease activity

KGMU 1.00 April 05- March 06

Flow Cytometric analysis of DNA ploidy and cell cycle in buccal mucosal cells in smokeless tobacco consumers

ICMR 26.00 March 06- Feb.09

Cytochrome P450s (P450s) in cultured rat brain cells: cell specific inducibility and vulnerability to environmental chemicals

CST-UP 5.40 Oct. 04- Sept. 07

Potential of black tea and its constituents in reversal of multi drug resistance and as bio-enhancer in cancer chemoprevention

DBT 52.00 Nov. 05- Nov. 08

To study the genetic stability of bacterial strain from earthworm gut in situ application in detoxification of endosulfan

CST-UP 5.40 Aug. 06 - Aug. 09

Neurotoxicity of synthetic pyrethroid (Lambda-cyhalothrin) pesticide: behavioral, neurochemical and immunohistochemical studies in developing and young rats

ICMR 20.00 April 07 - March 10

Development of ELISA & PCR based tests for GM Crops & Food

DBT 56.00 August 07- July 10

Role of microRNAs in neuronal differentiation and regulation of their expression by known

DBT 17.00 May 09-May 12

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developmental neurotoxins

Identification and validation of early biomarkers for predicting toxicity including pre-carcinogenic leasons in individuals occupationally exposed to PAHs and through tobacco

Indo-US (ICMR)

60.00 May 12-May 15

Prenatal viral infection: neuroimmunoigical, molecular and cognitive consequences during development, adulthood and senility in mice

ICMR 60.00 May 13-May 16

Intramural projects as Principal Investigator

Establishment and validation of primary cultures of brain cells as in vitro model for neurotoxicity

CSIR (CMM-0018)

50.00 April 02-March 07

Establishment and validation of in vitro model system for cytotoxicity assessment

CSIR (CMM-0018)

22.14 April 02- March 07

Stem cells: in vitro tool to understand the mechanisms of pesticide induced developmental neurotoxicity

CSIR (NWP-34)


Development and validation of in vitro models of developmental neurotoxicity

CSIR (SIP-08)


Stem cell derived skin dendritic cells: an in vitro tool to assess the immune-toxicity of environmental contaminants

CSIR (NWP-17)


Development and validation of in vitro models for cytotoxicity, neurotoxicity and metabolism assessment

CSIR (NWP-34)


Secretome based stage specific markers of developmental neurotoxicity in hematopoietic stem cell derived differentiating neuronal

CSIR (BSC-0111)


Molecular imprinting of genes associated with neural development, injury and repair in differentiating neural cells derived from human umbilical cord blood stem cells

CSIR (BSC-0111)


In vitro model of ischemic cerebral stroke: applicability of human neuronal cells derived from umbilical cord blood stem cells

CSIR (BSC-0103)


Consultancy/sponsored projects

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Besides the R/D work, I am also involved in consultancy/ sponsored projects from the Industries/ Public Sectors/ Non-Government organizations. Since 2001, I have been participated in the consultancy projects of worth more than 300,000.00 lacs.

(d) Participation in “Major Programs” identified at the National level:

Sl. No

Title of the Project Coordinating Agency

Contribution being made by you as representative of your

organization*

1 Good Laboratory Practices NGCMA, DST New Delhi

National GLP Inspector

2 Quality Management System BIS New Delhi

Member, Task force for plastic and polymeric products (PCD-12, PCD-21)

3 National SOP for Patients Consent in India

Institute of Medicine & Law, Mumbai

Member, Drafting Committee

4 Quality Management System CSIR-IITR-NABL Authorized Signatory for Plastic & Polymer Studies

Technical Operation Manager

5 Integrated NextGen approaches in health, disease and environmental toxicity (BSC-0111)

CSIR-IITR Lucknow

PI for two R&D activities

6 New approaches towards understanding of disease dynamics and to accelerate drug discovery (BSC-0103)

CSIR-CDRI Lucknow

PI for one R&D activity

7 Investigative Toxicology: New paradigms (Supra-institutional Project-SIP-08)

CSIR-IITR Lucknow PI for two R&D activities

(e) Participation and contributions made for the strategic sector:

Being GLP Inspector of National GLP Compliance Monitoring Authority, Department of Science & Technology, Ministry of Science & Technology, Government of India, I am providing my inputs to ensure the implementation of OECD principles of GLP in the GLP certified Laboratories in the country. The same job was also done for getting GLP accreditation system in CSIR-Indian Institute of Toxicology Research, Lucknow.

Being ‘Technical Operational Manager’, Biological Sciences, for NABL activities at CSIR-Indian Institute of Toxicology Research, Lucknow, my duties are to ensure that the compliance of ‘Laboratory Quality Management System and Internal Audit’ are as per IS/ISO/IEC 17025:2005 and ISO/IEC 17025:2005, ISO 15189:2007 Standards.

Being a Member of National Review Committee for Plastic and Polymeric products at Bureau of Indian Standards (PCD-12 and 21), I am providing my intellectual inputs in the preparation and revision of National Guidelines of Standards.

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The data generated on neurotoxicity/ developmental neurotoxicity and neuroprotection in human stem cell derived neuronal cells/ PC12 cells (rat pheochromocytoma cells) will lead to rapid in vitro tool to predict the mechanisms involved in chemical induced neurotoxicity and neuroprotection. The model developed will be helpful for regulatory agencies to incorporate new objective in vitro endpoint for the pre-screening of chemicals for neurotoxicity/ developmental neurotoxicity.

(f) Mentorship provided (Students guided, teaching etc.):

M Sc : One hundred and forty six

MDS : Thirty one

M Tech : Eighteen

B Tech : Eighteen

PhD : Fifteen (Awarded) Six (Currently working)

TWAS Fellow : One PhD Awarded (I was Co-Guide)

Co-ordinator (Stem Cells, Regeneration and Aging course-205) in the Academy of Scientific and Innovative Research (AcSIR):

Since the day of inception, I am a part of AcSIR as Member of the committee of curriculum design at CSIR-IITR, Lucknow. I was involved in the designing of course curriculum of the following credits: Research Methodologies, Ethics and Safety; Cell Signaling; Stem cells, Regeneration and Aging; Systemic Toxicology. I am serving as a Course coordinator of ‘Stem cells, Regeneration and Aging’.

In each semester, I am delivering the lectures as per the following schedule:

Sl. No

Subject/Course Credits No. of Students

Lecture/ Hours

Practical Sessions

1 Research Methodologies, Ethics and Safety (104)

One Compulsory Two -

2 Cell Signaling (206) Two Variable batch wise

Four -

3 Stem Cells, Regeneration and Aging (205) One Variable batch wise

Sixteen Two

4 Systemic Toxicology (307) Two Variable batch wise

Four -

5 Neurobiology (363) Two Variable batch wise

Two -

(g) Expert Member in National Regulatory/Scientific Bodies:

National GLP Inspectors, Department of Science & Technology, Ministry of Science &

27


Technology, Government of India, New Delhi.

Secretary General, Society of Toxicology, India, since May 2012-November 2014.

Technical Operational Manager, in a team of NABL for biosafety assessment of plastic and polymeric products at Institute level. The role is to ensure the compliance of ‘Laboratory Quality Management System and Internal Audit’ as per IS/ISO/IEC 17025:2005 and ISO/IEC 17025:2005, ISO 15189:2007 Standards.

Member, National Review Committee for Plastic and Polymeric products at Bureau of Indian Standards (PCD-12 and 21).

Honorary e-consultant for Toxicology and Forensic Sciences through www.indmedica.com

Member, Advisory Board of Research & Executive Council of National Centre for Stem Cell Technology & Research (India), UP (Since January 2008- till date)

Member, Panel of Expert for the assessment of Scientists working at Central Research Institute (Ayurveda), Central Council for Research Ayurveda and Siddha, Ministry of Health & Family Welfare, Govt. of India. (Since 2008- till date)

Member, Biosafety Committee, Aligarh Muslim University, Aligarh. (Since 2009- till date)

Member, Research Council, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow (UP)

Chairman, ‘Ethical Clearance Committee for Stem Cell Research’ at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow (UP)

Member Secretary, Institutional Biosafety Committee, CSIR-Indian Institute of Toxicology Research, Lucknow (UP)

Member, Institutional Animal Ethics Committee, Baba Bhimrao Ambedkar University, Lucknow (UP)

Member, Research Council, Amity University, Lucknow (UP)

Member, Research Council, Integral University, Lucknow (UP)

Member, Research Committee Biotechnology, Gautam Buddha Technical University, Lucknow (Formerly: UP Technical University, Lucknow)

Member, Selection Committees of more than ten Universities in India.

Member, Selection Committee for the appointment of faculty position at Pt. RN Sharma Institute of Ayurveda, Alternate Medical Education and Research, Bundelkhand University, Jhansi, on July 9, 2008.

Chair the Scientific Sessions in more than fifty National and International Symposia/ Conferences held at various parts of the country in last 5-6 years.

Chairman of the selection panel constituted for the interview of aspirants for admission in B.Tech, MSc. and M.Tech. courses in Amity University, Lucknow (2008-2012)

(h) Editorial Assignments:

Editorial Member: Sceintific Report (Stem Cells and Development Section), a Journalof Nature Publishing Group (December 2014- till date)

Academic Editor: PLoS ONE, world’s largest online journal (January 2012- till date)

Advisory Member: Toxicology Research, a journal of Royal Society of Chemistry(January 2012- till date)

28


Executive Editor: Journal of Clinical Toxicology (January 2013- till date)

Managing Editor: Toxicology International, the official journal of the Society ofToxicology, India (January 2010- November 2014)

Editor: Journal of Ecophysiology and Occupational Health, an officialjournal of Academy of Environmental Biology, India (January2006- till date)

Member: International Editorial Board of National Journal of Physiology,Pharmacy and Pharmacology (March 2011 – till date)

Senior Editor: ‘The Age of Biotechnology’ for Microbiology/Pharmacy/Biomedical Section (January 2011- till date)

Editorial Member: News Bulletin of Environmental Mutagenesis Society of India(January 2004 -December 2006)

Member: International Editorial Board, IMTU Medical Journal (April 2012-till date)

Review Editor: Frontiers in Pharmacogenetics and Pharmacogenomics (January2013-till date)

Associate Editor: Annals of Neurosciences, an official journal of Indian Academy ofNeurosciences (January 2015-till date)

(i) Workshops/Symposia organized (Ten Years):

1. Co-Convener in “Training Workshop on Scientific Communication” held at Industrial Toxicology Research Centre, Lucknow during on July 24 and 25, 2004.

2. Joint Organizing Secretary in “National Symposium on Safety Assessment of Cosmetics” held at Industrial Toxicology Research Centre, Lucknow during November 18-19, 2004.

3. Joint Organizing Secretary in “International symposium on Diet in Causation & Prevention of Cancer, along with XXX Annual Conference of Environmental Mutagen Society of India held at Industrial Toxicology Research Center, Lucknow during on March 17-19, 2005.

4. Joint Organizing Secretary in “International Update on Basic and Clinical Neuroscience Advances” and XXII annual meeting of Indian Academy of Neurosciences to be held at Industrial Toxicology Research Center, Lucknow during on December 17-20, 2006.

5. Organizing Secretary in the Symposium on ‘Neurodegeneration and Neuro-regeneration: Current Trends and Future Strategies’ held at Industrial Toxicology Research Centre, Lucknow, on July 30, 2007.

6. Organizing Secretary of International Conference on Recent developments, future prospects and entrepreneurial trends in biotechnology, held at IET Biotechnology Institute, Northern Extension, MIA, Alwar, Rajasthan, during December 19-21, 2009.

7. Joint Organizing Secretary of 5th Federation of Asian and Oceanian Neuroscience Societies (FAONS) Congress-2010 & XXVIII Annual Meeting of Indian Academy of Neurosciences, held at Lucknow, during November 25 - 28, 2010.

8. Organizing Secretary in the 32 Annual Meeting of Academy of Environmental Biology, India, held at Indian Institute of Toxicology Research, Lucknow-India, during September 21-23, 2012.

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9. Organizing Secretary of the Brain Awareness Week held at Regional Science City, Lucknow on March 28, 2012.

10. Organizing Secretary: One day National workshop of GLP held at CSIR-Indian Institute of Toxicology Research, Lucknow-India, on December 4, 2012

11. Jt. Organizing Secretary in the 32 Annual Meeting of Society of Toxicology, India and International Symposium on New Paradigms in Toxicology held at CSIR-Indian Institute of Toxicology Research, Lucknow-India, during December 5-7, 2012.

12. Organizing Secretary in the National Symposium on “Recent Progress in Nanomaterial Toxicity/ Biosafety”, a satellite symposium of Society of Toxicology, India, held at CSIR-Indian Institute of Toxicology Research, Lucknow-India, on July 25, 2014.

Date: September 4, 2017Place: Lucknow-India

AB PantPrincipal Scientist

System Toxicology & Health Risk assessment Group CSIR-Indian Institute of Toxicology Research

Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, P.O. Box No. 80, Lucknow-226 001

Uttar Pradesh, India.

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