fp7 fmtxct project umce-hgugm first year activity report partner fihgm
DESCRIPTION
FP7 FMTXCT Project UMCE-HGUGM first year activity report Partner FIHGM. Laboratorio de Imagen M é dica. Medicina Experimental Hospital Universitario Gregorio Mara ñó n, Madrid. Workpackage 2: XCT development Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT. - PowerPoint PPT PresentationTRANSCRIPT
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FP7 FMTXCT ProjectUMCE-HGUGM first year activity report
Partner FIHGM
Laboratorio de Imagen Médica. Medicina ExperimentalHospital Universitario Gregorio Marañón, Madrid
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Workpackage 2: XCT development
Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT
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Workpackage 2: XCT development
Use of X-ray contrast agents
Double exposure techniques
Dual energy X-ray source
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CT System OutlineMechanical Design
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Multi-Energy data acquisition/processingNew Tube Features
Voltage setting range 40 to 110 kV
Current setting range 10 to 800 μA
Output window Beryllium (thickness 500 μm)
Focal spot size 15 μm (6 W) – 80 μm (50 W)
Emission angle 62 deg (max)
Power 50 W
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Detector Dynamic Range Expansion
Dual-Exposure technique
Main features
• Two datasets acquired
• First
• Low SNR for dense materials
• Detector not saturated for soft materials
• Second
• High SNR for dense materials
• Detector saturated for soft materials
• Same X-ray beam spectral properties
• Different photon flux
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Detector Dynamic Range Expansion
Dual-Exposure technique
Dataset #1 Dataset #2
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Detector Dynamic Range Expansion
Dual-Exposure technique (work in progress)
Dual exposure
CNR (PTFE/Air) = 22.11
Single exposure
CNR (PTFE/Air) = 13.91
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0 50 100 1500
1
2
3
4
5
6
7x 10
4
keV
Pho
ton
Out
put
Predicted Spectrum with and without added filtration
100kVp with 0.5mm Be Inherent filtration
Added Filtration: 2mm Al, 0.75mmCu
0 50 100 1500
1
2
3
4
5
6
7x 10
4
keV
Pho
ton
Out
put
Predicted Spectrum with and without added filtration
100kVp with 0.5mm Be Inherent filtration
Added Filtration: 2mm Al, 0.1mmCu
Mean Energy = 55.6 kV Mean Energy = 66.1 kV
Multi-Energy data acquisition/processingSimulated Spectra for the new tube
• Changing filter setting
Spectral simulations carried out using SPEKTR software librariesSiewerdsen, et.al., “Spektr: A computational tool for x-ray spectral analysis and imaging system optimization”, Med. Phys.31(9), 2004
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0 50 100 1500
1
2
3
4
5
6
7x 10
4
keV
Pho
ton
Out
put
Predicted Spectrum with and without added filtration
100kVp with 0.5mm Be Inherent filtration
Added Filtration: 2mm Al, 0.1mmCu
Mean Energy = 34.9 kV Mean Energy = 66.1 kV
Multi-Energy data acquisition/processingSimulated Spectra for the new tube
• Changing X-ray tube setting
0 50 100 1500
0.5
1
1.5
2
2.5
3x 10
4
keV
Pho
ton
Out
put
Predicted Spectrum with and without added filtration
60kVp with 0.5mm Be Inherent filtration
Added Filtration: 2mm Al, 0.1mmCu
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Fenestra Iopamiro
Use of X-ray contrast agents
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Mouse
200 µA, voltage 50 kV
200 µm
Fenestra LC
Mouse
200 µA, voltage 50 kV
200 µm
Iopamiro
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Mouse
200 µA, voltage 50 kV
200 µm
Iopamiro
Dynamic study
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Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT
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Materials selection for the optical phantom construction
Water
Gelatin
Silicon Ti02 Pro Jet
Polyester resin India ink
Lipid emulsions
(Intralipid)
Polymer microspheres
Bulk materials Scatterers Absorbers
+ +
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Things to have in mind when designing a FMT phantom.
Resolution is depth dependent
Diffusion approximation: One photon mean free path ≈ 1mm
SourceDetector
Source
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Things to have in mind when designing a FMT phantom.
Heterogeneities, surface
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Phantom design
Heterogeneities
4 mm
Fluorescent spheres, 2 mm
(Should their size vary?)
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FMT-XCT
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How to insert the fluorophore in the phantom?
Resin vs Silicon
- Mix the fluorophore with the bulk material*
- Capillaries (diffusive-non diffusive interfaces)
- Pellets
* John Baeten et al “Development of fluorescent materials for Diffuse Fluorescence Tomography standars and phantoms” Optics express vol 15 2007
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What to measure
Resolution. FWHM of point-like source?
Quantification accuracy
Sensitivity: In-vivo specific application
PET phantom remarks
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Will the imaging performance hold in the “many body imaging situation”?
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PET phantom
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PET phantom
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PET phantom
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Detector Dynamic Range Expansion
Dual-Exposure techniqueMain features
• X-ray tube current calculation for the second scan
• Based on Histogran processing
• Shift the histogram to place 75% of the total value into the High-Gain region
• Dataset combination
• Detector Model
• Image combination based on a Maximum-Likelihood calculation assuming Independent Gaussian distribution.
( ) j
iij ijx
AY N
e
- i : Acquisition number
- j : Pixel number
- A: Current value
- N: Noise value
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FMT system
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Resultados preliminares, maniquíes:
Agar based, TiO2 (scatter), Blank ink (absorption)
coronal Z=0.25 cm
Planar imaging