francis a. cucinotta, ph.d. kerry george honglu wu, ph.d.€¦ · francis a. cucinotta, ph.d. kerry...
TRANSCRIPT
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Biodosimetry and Space Radiation Risks
Francis A. Cucinotta, Ph.D.Kerry George
Honglu Wu, Ph.D.
NASA Johnson Space Center, Houston, Texas, USA
48th International Congress of Aviation and Space MedicineRio de Janeiro, Brazil, September 17-21, 2000
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S
GALACTIC COSMIC RADIATION (GCR)(Protons to Iron Nuclei)
SOUTH ATLANTIC ANOMALY(Protons)
INNER RADIATION BELT(Protons)
OUTER RADIATION BELT(Electrons)
The Space Radiation Environment
SOLAR PARTICLE EVENT(Protons to Iron Nuclei)
Representation of the major sources of ionizing radiation of importanceto manned missions in low-Earth orbit. Note the spatial distribution of
the trapped radiation belts.
NOUTER RADIATION BELT
(Electrons)
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Energy spectrum of trapped protons
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Solar particle events
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Galactic cosmic radiation
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Summary of space radiation environment
• Major sources: Trapped protons, GCR, solar particle events
• Radiation type: Protons and heavy ions
• Energy of interest: 100 MeV/u ~10000 MeV/u
• Secondary neutrons
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Chromosome aberrations induced by charged particles in human lymphocytes
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Biodosimetry for space radiation exposure
• Limitation of physical dosimeters
• Lack of understanding of the genetic effects of heavy ions
• Lack of understanding of the synergistic effect of radiation and microgravity
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Biodosimetry procedure
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Simple exchange
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Complex exchange
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Lucas et al. Radiation Research 1997
Comparison of in vitro and in vivo results
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Calibration curve for chromosome aberrations
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Tucker et al. Mutation Research 1994
Background frequency of chromosome aberrations
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Dose response of chromosome aberrations
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Biodosimetry results
Subject TLD reading(cGy)
Biological dose measuredusing values for
translocation (cSv)
AverageRBE*
1 3.06 16 4.22 3.78 18 3.83 5.68 20 2.84 4.16 23 4.45 4.16 14 2.76 4.16 12 2.3
*25% correction for high-LET radiation in TLD measurement isincluded.
Mission duration: 3-5 monthsAltitude: 190 NMInclination: 51.6 degree
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Conclusions
• Space radiation risk assessment– Ground based investigations– Flight experiments
• Countermeasures– Physical– Biomedical