Fueling innovation in the premiumdental market

Francisco FaoroHead Product Development BUSurgical

8 October 2012

A pioneer of dental implants

Founded as a family owned researchinstitute in 1954

Headquartered in Basel, Switzerland

Dental solutions available in more than70 countries through 20 fully ownedsales subsidiaries and a broaddistributor network

>2400 employees from 30+ nations

Straumann – a global leader in replacement,restorative and regenerative dentistry

Straumann 2

1954 – 1970Material testing

and research

1970 – 1990Medical devices

Since 1990Dental medical

devices

Half a century of science-based innovation andprecision engineering

1974First StraumannDental implant

Straumann 3

A global business…

Gräfelfing (D):scanner assembly

Leipzig (D):CADCAM milling

Malmö (S):Regenerative productsAndover (USA):

Implant production

Villeret (CH):Implant production

Present in >70 countries through 20 sales subsidiaries and a broad distributor network

Arlington (USA):CADCAM milling

Straumann subsidiaries

Production plants

Distributors

Head Quarter

Straumann 4

…has achieved leadership through organic growthand innovation

Innovation

Geographical

Gro

wth

Straumann

Tooth replacement,restoration and

regeneration

Global GDP

Drivers

Straumann 5

Expandingprovider base

Solution andservice

Straumann

New surface scored highest in the USNew surface and new material ranked top in EuropePrevention of peri-implantitis scored best in Asia

Factors influencing customer choiceof implant company1

What drives the choice to buy premium products?

Proportion of respondents2 willing to pay apremium for indicated product features

0

20

40

60

80

100

New surface New material Prevention ofperi-implantitis

Optimal size

%

28%

18%

6%

48%

Service & practice supportEducationPricingInnovation & product performance

Straumann 61 Perception pulse study: dental implants 2011; 2046 respondents in Americas, Asia, and Europe, MRG2 SAi MedPartners 2011 Sample: 170 respondents in Americas, Asia, and Europe

Innovation leadership based on surface- and materialscience

Inno

vatio

n

1974 TPSBetter osseointegration

1994 SLA®Enhanced osseointegration

2009 Roxolid®Enhanced mechanical properties

1970Blade

implants

1960Invasive

implants inlower jaw

2011 NNC®Small diameter implants

with wider indication

400b.c.metal straps(Etruscan)

600a.c.ivory teeth(Honduras)

2005 SLActive®Superior osseointegration

Straumann 7Straumann

Market

Time

Macro

19741st generation

Micro

19942nd generation

SLActiveMolecular

20053rd generation

SLActive

Straumann leads implant surface innovation

SLATPS

Straumann 8

Development of surfacetopography

Development of surfacechemistry

Hydrophilic surface cuts healing time in half1

Hydrophobic sand blastedand acid etched titanium

surface2

Body can immediately accessthe active surface for

osseointegration

Body has to remove the passivelayer for osseointegration

Straumann 91 Raghavendra, Wood, Taylor, 2005 and Oates et al., 20072 Straumann SLA®3 Straumann SLActive®

Hydrophilic sand blastedand acid etched titanium

surface3

Bone remodelling with SLActive® also in large defects

Straumann 10Histological cross-sections at 12 weeks after implant placement

Results from preclinical studies presented by Becker J, Schwarz F (Heinrich-Heine University,Düsseldorf, Germany) at 15th Ann. Sci. Meeting of the EAO, Zürich, 2006

SLA®Implant

Surroundingbone

Newbone

SLActive®Implant

Surroundingbone

There is an increasing trend towards narrow implantswhich is based on …

Clinical needs:- small bone ridge- small inter-dental gap- bone conservation

Patient requirements:- less invasive treatment- reduced treatment time- less cost intensive- aesthetic solution

Straumann 11With courtesy of Dr Roccuzzo, Italy

Roxolid® designed for more confidence by combiningstrength and excellent osseointegration

Higher strength than pure titanium1,2,3

Higher stability1,2,3

More bone in-growth4

Improved osseointegration4

0

500

1000

1500

Tens

ileS

tregh

t[M

pa]

ASTMTiGr41)

STMNTiGr42) Roxolid3)

Straumann 12

1 ASTM F672 used for all Ti Straumann implants3 used for all Roxolid Straumann implants4 Gottlow, J., et al. "Evaluation of a New Titanium-Zirconium Dental Implant: A Biomechanical andHistological Comparative Study in the Mini Pig." Clin.Implant.Dent.Relat Res. (2010).

RoxolidImplant

Surrounding bone

The usage of narrow implantsis currently limited to frontteeth

Straumann 13

Narrow implants have limited treatment options

Straumann 14

0

50

100

150

200

250

300

350

400

0 1 2 3 4 5 6

Benchmark for anterior region1

Benchmark for pre-molar region1

Benchmark for molar region1

Ø Implant [mm]

Fatig

uest

reng

th[N

]

Strong correlation between implant diameter and its fatigue stregth2

1 2012-09-05 Mech Strength Benchmarking for Dent Impl Syst_V02 (Straumann internal data)2 According to ISO 14801; data on file (Straumann)

Enhanced materialCurrent material

To maintain leadership in innovation – leapfroggingtechnology in materials is needed

ASTMTiGr4

StraumannTiGr4

Roxolid® Enhancedmaterial

0

200

400

600

800

1000

1200

1400

?

Straumann 15

Tens

ileSt

reng

th[M

Pa]

www.straumann.com