fuming zhang, phd...fuming zhang, phd research professor department of chemical and biological...
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Fuming Zhang, PhD Research Professor
Department of Chemical and Biological Engineering
Rensselaer Polytechnic Institute (RPI)
110, 8th
St. Troy, NY 12180
Tel. 518-276-6839, email: [email protected]
EDUCATION
Ph. D. Microbiology, The University of Leeds, Leeds City, UK,1997
Thesis title: “The treatment of colored effluents with wood rotting fungi”
Advisers: Dr. Jerry Knapp, and Dr. Kelvin Tapley
MS courses in Biochemical Engineering, Zhejiang University, 1991-1993
B. Eng. Biochemical Engineering, HuaQiao University, China, 1986
Thesis title: “Studies on fermentation and purification of L-lysine”
Adviser: Professor Wenluang Lin
RESEARCH EXPERIENCE
July 2012 to present Research Professor, Rensselaer Polytechnic Institute (RPI)
2008 to 2012 Research Associate Professor, Rensselaer Polytechnic Institute (RPI)
2003 to 2008 Research Assistant Professor, Department of Chemical and Biological Engineering,
Rensselaer Polytechnic Institute (RPI)
2001 to 2003 Assistant Research Scientist in Linhardt’s Lab, The University of Iowa
Study on protein and carbohydrate interaction with SPR (BIAcore) technology
1999-2001 Research Associate, The University of Iowa
Recombinant protein production using insect cell-baculovirus expression system
and the development of glycan analysis of glycoprotein
1998-1999 Research Associate, Hong Kong University of Science and Technology
Bioremediation of industrial pollutants with white rot fungi and biodegradation of
polymer in solid wastes
1994-1997 PhD student, The University of Leeds, UK
The treatment of colored effluents with wood rotting fungi
1986-1994 Research Scientist, Zhejiang University of Technology, China
INDUSTRIAL EXPERIENCE
1993~1994 Consultant Research Scientist, Qianjiang Biochemical Ltd. Zhejiang, China.
Developed biochemical products (Iso-Vitamin C, Alkaline Protease) and
optimized the bioprocesses
1992~1993 Research Scientist, Changzhen Chemical Ltd. Hangzhou, China.
Investigated a pilot project: Alcohol Fermentation Using Immobilized Yeast Cells
TEACHING EXPERIENCE
2010 Glycochemistry, Glycobiology and Glycotechnology (Course #6961 coordinated by
Professor Linhardt)
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2004 to present Genetic Engineering (Course #6310, coordinated by Prof. J. Koretz)
1999-2004 Supervisor of graduate student projects, The University of Iowa, and RPI
1995-1997 Supervisor of final year projects, The University of Leeds, U.K
1992-1994 Lecturer, lecturing courses: Biotechnology Processes and Antibiotics Fermentation
Technology, Zhejiang University of Technology
AWARDS
Research Excellent Award, Rensselaer Polytechnic Institute (RPI), 2012
Scientific Achievement Award, Zhejiang Provincial Government, China, 1993
Certification of Merit (Distinguished graduate), HuaQiao University, China, 1986
AFFILIATIONS Society for General Microbiology (UK)
American Institute of Chemical Engineers (AIChE)
American Chemical Society (ACS)
Society for Glycobiology
EDITORIAL BOARD MEMBER
Journal of Biomedical Technology and Research, since 2013
Journal of Biotechnology and Bioengineering, since 2014
Journal of Bioanalytical techniques, since 2015
PUBLICATIONS
1. L. Fu, K. Li, D. Mori, M. Hirakane, L. Lin, N. Grover, P. Datta, Y. Yu, J. Zhao, F. Zhang, M.
Yalcin, S. Mousa, J.S. Dordick, R.J. Linhardt, Enzymatic generation of highly anticoagulant
bovine intestinal heparin, Journal of Medicinal Chemistry, in press 2017
2. L. Hou, X. Zhang, P.E. Mikael, L. Lin, W. Dong, Y. Zheng, T. J. Simmons, F. Zhang, R. J.
Linhardt, Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering, ACS Omega, 2,
6321−6328, 2017.
3. Z. Liu, F. Zhang, W. He, R. J. Linhardt, Characteristics of global organic matrix in normal and
pimpled chicken eggshells, Poultry Science, 96, 3775–3784, 2017.
4. Y. Yu, N. Zang, F. Zhang, R. J. Linhardt, H. Zhang, Proteome analysis and selenium-binding
peptide identification on proteins sequentially extracted from loach (Misgurnus anguillicaudatus),
Biochemistry and Physiology, 6, 1000214, 2017.
5. G. Li, Lingyun Li, E. J. Joo, J. W. Son, Y. J. Kim, J. K. Kang, K. Bok Lee, F. Zhang, R. J.
Linhardt, Glycosaminoglycans and glycolipids as potential biomarkers in lung cancer,
Glycoconjugate Journal, 34, 661–669, 2017.
6. H. Wang, W. He, P. Jiang, Y. Yu, L. Lin, X. Sun, M. Koffas, F. Zhang, Robert J. Linhardt,
Construction and functional characterization of truncated versions of recombinant keratanase II
from Bacillus circulans, Glycoconjugate Journal, 34, 643–649, 2017.
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7. Z. Liu, L. Song, L. Lu, X. Zhang, F. Zhang, K. Wang, R. J. Linhardt, Comparative proteomics of
matrix fractions between pimpled and normal chicken eggshells, Journal of Proteomics, 167, 1–11,
2017
8. F. Wang, Y. Ma, Y. Liu, X. Zhang, F. Zhang, R. J. Linhardt, Improved octyl glucoside synthesis
using immobilized β-glucosidase on PA-M with reduced glucose surplus inhibition. Biocatalysis
and Biotransformation, 35, 349–362, 2017.
9. Y. Yu, M. Hirakane, D. Mori, L. Lin, F. Zhang, H. Zhang, R. J. Linhardt, Structural and activity
variability of fractions with different charge density and chain length from pharmaceutical
heparins, Glycoconjugate Journal, 34, 545–552, 2017
10. L. Wang, H. Zhang, L. Yang, X. Liang, F. Zhang, R. J. Linhardt, Structural characterization and
bioactivity of exopolysaccharide synthesized by Geobacillus sp. TS3-9 isolated from radioactive
radon hot spring, Advances in Biotechnology and Microbiology, 4, 1-8, 2017
11. Y. G. Fulcher, S. H. Prior, S. Masuko, L. Li, D. Pu, F. Zhang, R. J. Linhardt, S. R. Van Doren,
Glycan Binding that Directs a Sheddase: Electrostatic Recognition between Heparin and the MMP-
7 Zymogen, Structure, 25, 1100–1110, 2017
12. J. Zhao, X. Liu, A. Malnotra, Q. Li, F. Zhang, R. J. Linhardt, Novel Method for Measurement of
Heparin Anticoagulant Activity Using SPR, Analytical Biochemistry, 526, 39-42, 2017.
13. Q. Xie, J. Spear, A. Noble, D. Sousa, N. Meyer, O. Davulcu, F. Zhang, R. Linhardt, S. Stagg, M.
Chapman, The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a
Heparanoid Pentasaccharide. Molecular Therapy - Methods & Clinical Development, 5, 1-12, 2017
14. S. Y. Kim, J. Zhao, X. Liu, K. Fraser, L. Lin, F. Zhang, J. S. Dordick, R. J. Linhardt, Interaction of
Zika Virus with Glycosaminoglycans. Biochemistry, 56, 1151−1162, 2017.
15. J. Zhao, I. Huvent, G. Lippens, D. Eliezer, A. Zhang, Q. Li, P. M. Tessier, R. J. Linhardt, F.
Zhang, and C. Wang, Glycan Determinants of Heparin-Tau Interaction, Biophysical Journal, 112,
921–932, 2017.
16. Y. Yang, S. M. Haeger, M. A. Suflita, F. Zhang, K. L. Dailey, J. F. Colbert, J. A. Ford, M. A.
Picon, R. Stearman, L. Lin, X. Liu, X. Han, R. J. Linhardt, E. P. Schmidt, Fibroblast growth factor
signaling mediates pulmonary endothelial glycocalyx reconstitution, American Journal of
Respiratory Cell and Molecular Biology, 56, 727-737, 2017.
17. J. A. Englaender, Y. Zhu, A.N. Shirke, L. Lin, X. Liu, F. Zhang, R.A. Gross, M.A.G. Koffas, R. J.
Linhardt, Expression and secretion of glycosylated heparin biosynthetic enzymes using
Komagataella pastoris, Applied Microbiology and Biotechnology, 101, 2843–2851, 2017.
18. Y. Chen, L. Lin, I. Agyekum, X. Zhang, K. St.Ange, Y. Yu, F. Zhang, J. Liu, I. J. Amster, R. J.
Linhardt, Structural Analysis of Heparin-Derived 3-O-Sulfated Tetrasaccharides: Antithrombin
Binding Site Variants, Journal of Pharmaceutical Sciences, 106, 973-981, 2017.
19. X. Liu, K. St.Ange, X. Wang, L. Lin, F. Zhang, L. Chi, R. J. Linhardt, Parent heparin and daughter
LMW heparin correlation analysis using LC-MS and NMR, Analytical Chemica Acta, 961, 91-99,
2017.
20. V. Schultz, M. Suflita, X. Liu, X. Zhang, Y. Yu, L. Li, D. E. Green, Y. Xu, F. Zhang, P. L.
DeAngelis, J. Liu, R. J. Linhardt, Heparan Sulfate Domains Required for Fibroblast Growth Factor
1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c, Journal of Biological Chemistry,
292, 2495–2509, 2017.
21. F. Wang, Y. Ma, Y. Liu, Z. Cui, X. Ying, F. Zhang, R. J. Linhardt, A simple strategy for the
separation and purification of water-soluble polysaccharides from the fresh Spirulina platensis,
Separation Science and Technology, 52, 456-466, 2017.
22. L. Lin, X. Liu, F. Zhang, L. Chi, I. J. Amster, F. E. Leach III, Q. Xia, R. J. Linhardt, Analysis of
heparin oligosaccharides by capillary electrophoresis- negative-ion electrospray ionization mass
spectrometry, Analytical and Bioanalytical Chemistry,409, 411–420, 2017.
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23. X. Wang, X. Liu, L. Li, F. Zhang, M. Hu, F. Ren, L. Chi, R. J. Linhardt, GlycCompSoft: Software
for automated comparison of low molecular weight heparins using top-down LC/MS data,
PlosOne, in press, 2016.
24. S.-J. Kwon, D. H. Na, J. H. Kwak, M. Douaisi, F. Zhang, E. J. Park, J.-H. Park, H. Youn, C.-S.
Song, R. S. Kane, J. S. Dordick, K. B. Lee, R. J. Linhardt, Nanostructured glycan architecture is
important in the inhibition of influenza A virus infection, Nature Nanotechnology, in press, 2016.
25. Y. Yu, Y. Chen, P. Mikael, F. Zhang, A. M. Stalcup, R. German, F. Gould, J. Ohlemacher, H.
Zhang, R. J. Linhardt, Surprising absence of heparin in the intestinal mucosa of baby pigs,
Glycobiology, in press, 2016.
26. F. Wang, Y. Ma, Y. Liu, Z. Cui, X. Ying, F. Zhang, R. J. Linhardt, A simple strategy for the
separation and purification of water-soluble polysaccharides from the fresh Spirulina platensis,
Separation Science and Technology, http://dx.doi.org/10.1080/01496395.2016.1244549, 2016.
27. Y. Chen, M. Reddy, Y. Yu, F. Zhang, R. J. Linhardt, Glycosaminoglycans of the chicken muscular
stomach or gizzard, Glycoconjugate Journal, DOI: 10.1007/s10719-016-9737-4, 2016.
28. Y. Zhao, A. Singh, Y. Xu, C. Zong, F. Zhang, G.-J. Boons, J. Liu, R. J. Linhardt, R. J. Woods, I. J.
Amster, Gas-Phase Examination of the Complex of Fibroblast Growth Factor 1 with Heparan
Sulfate: a Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study,
Journal of the American Association of Mass Spectrometry, DOI: 10.1007/s13361-016-1496-8,
2016
29. K. A. Rubinson, Y. Chen, B. F. Cress, F. Zhang, R. J. Linhardt, Heparin's Solution Structure
Determined by Small-Angle Neutron Scattering (SANS), Biopolymers, 2016 Dec;105(12):905-13.
2016.
30. B. Mulloy, N. Wu, F. Gyapon-Quast, L. Lin, F. Zhang, M. C. Pickering, R. J. Linhardt, T. Feizi,
W. Chai, Abnormally high content of free glucosamine residues identified in a preparation of
commercially available porcine intestinal heparan sulfate, Analytical Chemistry, 2016 Jul
5;88(13):6648-52. 2016.
31. P. He, A. Zhang, F. Zhang, R. J. Linhardt, P. Sun, Structure and bioactivity of a polysaccharide
containing uronic acid from Polyporus umbellatus sclerotia, Carbohydrate Polymers, 2016 Nov
5;152:222-30, 2016.
32. H. Huang, X. Liu, S. Lv, W. Zhong, F. Zhang, R.J. Linhardt, Recombinant Escherichia coli K5
strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular
polysaccharide, Applied Microbiology and Biotechnololgy, 2016 Sep;100(18):7877-85, 2016
33. Z. Liu, X. Sun, C. Cai, W. He, F. Zhang, R. J. Linhardt, Characteristics of glycosaminoglycans in
chicken eggshells and the influence of disaccharide composition on eggshell properties, Poultry
Science, doi: 10.3382/ps/pew179, 2016.
34. L. Lin, X. Liu, F. Zhang, L. Chi, I. J. Amster, F. E. Leach III, Q. Xia, R. J. Linhardt, Analysis of
heparin oligosaccharides by capillary electrophoresis- negative-ion electrospray ionization mass
spectrometry, Analytical and Bioanalytical Chemistry, DOI: 10.1007/s00216-016-9662-1, 2016
35. K. St.Ange, A. Onishi, L. Fu, X. Sun, L. Lin, D. Mori, F. Zhang, J. S. Dordick, J. Fareed, D.
Hoppensteadt, Walter Jeske, R. J. Linhardt, Analysis of heparins derived from bovine tissues and
comparison to porcine intestinal heparins, Clinical and Applied Thrombosis and Hemostasis, 2016
Sep;22(6):520-7.
36. E. P. Schmidt, K. H. Overdier, X. Sun, L. Lin, X. Liu, Y. Yang, L. A. Ammons, T. D. Hiller, M. A.
Suflita, Y. Yu, Y. Chen, F. Zhang, C. Cothren Burlew, C. L. Edelstein, I. S. Douglas, R. J.
Linhardt, Urinary glycosaminoglycans predict outcomes in septic shock and ARDS, American
Journal of Respiratory and Critical Care Medicine, 2016 Aug 15;194(4):439-49.
37. L. Fu, X. Sun, W. He, C. Cai, A. Onishi, F. Zhang, R. J. Linhardt, Z. Liu, Keratan sulfate
glycosaminoglycan from chicken egg white, Glycobiology, 2016 Jul;26(7):693-700
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38. J. C. Fox, R. C. Tyler, F. C. Peterson, D. P. Dyer, F. Zhang, R. J. Linhardt, T. M. Handel, B. F.
Volkman, Examination of glycosaminoglycan binding sites on the XCL1 dimer, Biochemistry,
2016 Mar 1;55(8):1214-25
39. Y. Zheng, J. Miao, F. Zhang, C. Cai, A. Koh, T. J. Simmons, S. A. Mousa, R. J. Linhardt, Surface
modification of a polyethylene film for anticoagulant and anti-microbial catheter, Reactive &
Functional Polymers, 2016 Mar 1;100:142-150.
40. X. Sun, L. Lin, F. Zhang, L. Chi, Q. Xia, R. J. Linhardt, Capillary Electrophoresis-Mass
Spectrometry for the Analysis of Heparin Oligosaccharides and Low Molecular Weight Heparin,
Analytical Chemistry, 2016 Feb 2;88(3):1937-43
41. Y. Zheng, C. Cai, F. Zhang, J. Monty, R. J. Linhardt, T. Simmons, Can natural fibers be a silver
bullet? Antibacterial cellulose fibers through covalent bonding of silver nanotparticles to
electrospun fibers, Nanotechnology, 2016 Feb 5;27(5):055102
42. E. Ucakturk, O. Akman, X. Sun, D. E. Baydar, A. Dolgun, F. Zhang, R. J. Linhardt, Changes in
composition and sulfation patterns of glycoaminoglycans in renal cell carcinoma, Glycoconjugate
Journal, 2016 Feb;33(1):103-12. 2016.
43. F. Zhang, J. Zhang, R. J. Linhardt, Interactions between heparin/GAGs and nattokinase
Glycoconjugate Journal, 32, 695–702, 2015.
44. F. Zhang, K. B. Lee and R. J. Linhardt. SPR Biosensor Probing the Interactions between TIMP-3
and Heparin/GAGs. Biosensors, 5, 500-512, 2015.
45. Z.G. Liu, C.D. Wang, J.L. Hu, F. Zhang, R.J. Linhardt, X.C. Lin, Apparent Digestibility of Diet
Dominantly Comprised of Phyllostachys Vivax Bamboo Shoots for Captive Giant Pandas, Journal
of Animal and Plant Sciences 25, 612-617, 2015.
46. J. Y. Baik, H. Dahodwala, E. Oduah, L. Talman, T. R. Gemmill, L. Gasimli, P. Datta, B. Yang, G.
Li, F. Zhang, L. Li, R. J. Linhardt, A. M. Campbell, S.F. Gorfien, S. T. Sharfstein. Optimization of
bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin.
Biotechnology Journal, 10, 1067–1081, 2015.
47. C.P. Wang, V.C. Hascall, F. Zhang, R.J. Linhardt, A. Abbadi, A Wang, The responses of
hyperglycemic dividing mesangial cells to heparin is mediated by the non-reducing terminal
trisaccharide. Journal of Biological Chemistry, 2015 Sep 16. pii: jbc.M115.677401.
48. X. Sun, L. Li, K. H. Overdier, L. A. Ammons, I. S. Douglas, C. C. Burlew, F. Zhang, E.P.
Schmidt, L. Chi, R. J. Linhardt, Analysis of total human urinary glycosaminoglycan disaccharides
by liquid chromatography-tandem mass spectrometry, Analytical Chemistry, 87, 6220−6227, 2015.
49. G. Sua, L. Lia, W. Zhong, F. Zhang, R.J. Linhardt, Production of a low molecular weight heparin
using recombinant unsaturated glycuronidase, Carbohydrate Polymers, 134, 151–157, 2015.
50. S.-J. Kwon, F. Zhang, J. S. Dordick, W. J. Sonstein, R.J. Linhardt. Detection of cerebrospinal
fluid leakage by specific measurement of transferrin glycoforms. Electrophoresis, 36, 2425–2432,
2015.
51. U. Bhaskar, A.M. Hickey, G. Li, C. Cai, L. Fu, Z. Ou, R. V. Mundra, F. Zhang, J. S. Dordick, R. J.
Linhardt. A purification process for heparin and precursor polysaccharides using the pH
responsive behavior of chitosan. Biotechnology Progress, 31, 1348–1359, 2015.
52. Z. Li, H. Moniz, S. Wang, A. Ramiah, F. Zhang, K. W. Moremen, R. J. Linhardt, J. S. Sharp, High
structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin
binding interface, Journal of Biological Chemistry, 015 Apr 24;290(17):10729-40, 2015
53. J. Zhang, M. Suflita,G. Li, W. Zhong, L. Li, J. S. Dordick, R. J. Linhardt, F. Zhang, High cell
density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-
epimerase for the production of bioengineered heparin, Applied Biochemistry and Biotechnology,
175(6):2986-95, 2015
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54. Z. Liu, F. Zhang, L. Li, G. Li, W. He, R. J. Linhardt, Compositional analysis and structural
elucidation of glycosaminoglycans in chicken eggs, Glycoconjugate Journal, 31, 593–602, 2014.
55. F. Zhang, J. Xie, R. J. Linhardt, Isolation and structural characterization of glycosaminoglycans
from heads of red salmon (Oncorhynchus nerka), Journal of Biotechnology and Bioengineering, 1,
1-5, 2014.
56. L. Fu, S.A. McCallum, J. Miao, C. Hart, G. Tudryn, F. Zhang, R. J. Linhardt, Rapid and accurate
determination of the lignin content of lignocellulosic biomass by solid-state NMR, Fuel, 141 39–
45, 2015.
57. J. Zhang, M. Suflita, G. Li, L. Li, F. Zhang, J.S. Dordick, R. J. Linhardt, High cell density
cultivation of a recombinant Escherichia coli strain expressing a 6-O-sulfotransferase for the
production of bioengineered heparin, Applied Microbiology, in press, 2014.
58. John P. Jasper, Fuming Zhang, Russell B. Poe and Robert J. Linhardt, Stable-Isotopic Analysis of
Porcine, Bovine, and Ovine Heparins, Journal of Pharmaceutical Science, in press, 2014
59. L. Fu, L. Li, C. Cai, G. Li, F. Zhang, Robert J. Linhardt, Heparin stability by determining
unsubstituted amino groups using HILIC-MS, Analytical Biochemistry, 461, 46–48, 2014
60. F. Zhang, X. Liang,Y. Lee, and R. J. Linhardt, The effects of metal ions on heparin/heparin
sulfate-protein interactions, Journal of Biomedical Technology and Research, 1, 1-7, 2014,
(corresponding author) 61. Ucakturk, Ebru; Cai, Chao; Li, Lingyun; Li, Guoyun; Zhang, Fuming; Linhardt, Robert J.
Capillary electrophoresis for total glycosaminoglycan analysis. Analytical and Bioanalytical
Chemistry, 406, 4617–4626, 2014.
62. Peng Xu, Lingyun Li, Fuming. Zhang, Gregory Stephanopoulos, Mattheos Koffas, Improving
fatty acids production by engineering dynamic pathway regulation and metabolic control, PNAS,
111(31):11299-304, 2014
63. J. J. Aguilera, J. Beaudet, F. Zhang, R. J. Linhardt, W. Colón Glycosaminoglycan-modulated
divergent aggregation of Serum Amyloid A. Biochimie, 104, 70-80, 2014.
64. G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt, Analysis of 3-O-sulfo group containing
heparin tetrasaccharides in heparin by liquid chromatography-mass spectrometry, Analytical
Biochemistry,455, 3–9, 2014.
65. L. Fu, F. Zhang, G. Li, A. Onishi, U. Bhaskar, P. Sun,1 R. J. Linhardt, Structure and activity of a
novel low molecular weight heparin produced by enzymatic ultrafiltration, Journal of
Pharmaceutical Science, 461, 46–48, 2014.
66. Q. Wang, C. Wang, Y. Li. F. Zhang, Xinle Liang, Genome shuffling and ribosome engineering of
Streptomyces actuosus for high yield nosiheptide production, Journal of Industrial Microbiology &
Biotechnology, submitted. 2014
67. F. Zhang, H. A. Moniz, B. Walcott, K. W. Moremen, L. Wang and R. J. Linhardt, Probing the
impact of GFP tagging on Robo1-heparin interaction, Glycoconjugate Journal, 31, 299–307, 2014,
(corresponding author) 68. R. G. Walker, C. Kattamuri, D. M. Luedeke, F. Zhang, R. J. Linhardt, and T. B. Thompson,
Heparin and heparan sulfate alter follistatin binding to myostatin and activin A, Biochemistry,
submitted. 2014.
69. Fulcher, Yan; Sanganna Gari, Raghavendar; Frey, Nathan; Zhang, Fuming; Linhardt, Robert;
King, Gavin; Van Doren, Steven, Heparin activates a tumor-secreted protease via tethering and V-
type allostery, ACS Chemical Biology, 9: 957−966, 2014,
70. P. Xu, W. Wang, L. Li, N. Bhan, F. Zhang, M. Koffas, Design and kinetic analysis of a hybrid
promoter-regulator system for malonyl-CoA sensing in E. coli. ACS Chemical Biology, 9 (2):451–
458, 2014.
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71. Y.Yu, F. Zhang, D. Lu, H. Zhang, Selenium bioavailability from shrimps (Penaeus vannamei
Boone) and its effect on the metabolism of phospholipid and cholesterol ester, Journal of
functional Foods, Volume 6: 186–195, 2014.
72. G. Li, C. Cai, L. Li, L. Fu, Y. Chang, F. Zhang, T. Toida, C. Xue, R. J. Linhardt, Method to
detect contaminants in heparin using radical depolymerization and liquid chromatography-mass
spectrometry, Analytical Chemistry, 86(1):326-30, 2014
73. B. Zhang, W. Xiao, H. Qiu, F. Zhang, H. Moniz, A. Jaworski, E. Condac, G. Gutierrez-Sanchez,
C. Heiss, R. Clugston, P. Azadi, J. J. Greer, C. Bergmann, K. Moremen, D. Y. Li, R. J. Linhardt, J.
D. Esko, L. Wang, Heparan sulfate deficiency disrupts developmental angiogenesis and causes
congenital diaphragmatic hernia., Journal of Clinical Investigation, 124(1):209-21, 2014.
74. H. Huang，Y. Zhao，S. Lv，W. Zhong，F. Zhang，R. J. Linhardt, Quantitation of heparosan
with heparinase III and spectrophotometry, Analytical Biohemistry, 447:46-8, 2014.
75. J. M. Beaudet, L.Mansur, E. Joo, E. Kamhi, B. Yang, T. M. Clausen, A. Salanti, F. Zhang, R. J.
Linhardt, Characterization of human placental glycosaminoglycans and regional binding to
VAR2CSA in malaria infected erythrocytes, Glycoconjugate Journal, 31(2):109-16, 2014.
76. J. Xiong, U. Bhaskar, G. Li, L. Fu, L. Li, F. Zhang, J. S. Dordick, R. J. Linhardt, Immobilized
enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of
bioengineered heparin, Biotechnology Journal, 167(3):241-7, 2013.
77. L. Qiu, W. Chen, L. Zhong, W. Wu, S. Wu, J. Chen, F. Zhang, W. Zhong, Formaldehyde
biodegradation by immobilized Methylobacterium sp. XJLW cells in a three-phase fluidized bed
reactor, Bioprocess and Biosystems Engineering, DOI 10.1007/s00449-013-1110-4, 2013.
78. G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, C. Xue, J. Liu, P. L. DeAngelis, R. J.
Linhardt, N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its
analysis by oxidative degradation, Biopolymers, 99, 675-685, 2013.
79. F. Zhang, H.A. Moniz, B. Walcott, K. W. Moremen, R. J. Linhardt and L.Wang, Characterization
of the Interaction between Robo1 and Heparin/other Glycosaminoglycans, Biochimie, 95(12):2345-
53, 2013. (corresponding author)
80. F. Zhang, J. Aguilera, J. M. Beaudet, Q. Xie, T. F. Lerch, W. Colón, M. S. Chapman and R. J.
Linhardt. Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-
associated Virus, Biochemistry, 52, 6275–6285, 2013.
81. F. Zhang, B. Wacott, A. Wlodawer, M.L.V. Oliva and R. J. Linhardt, Kinetic and Structural
Studies on Interactions between Heparin/GAGs and a Crataeva tapia Bark Protein Using Surface
Plasmon Resonance, Biochemistry, 52, 2148−2156, 2013
82. F. Zhang, L. Fu, G. Li, B. Yang, A. Onishi, L. Li and R. J. Linhardt, Structural characterization of
heparins from different animal sources, Journal of Pharmaceutical Science, 102(5):1447-57, 2013
83. W. Wang, P. Xu, J. Dordick, F. Zhang, Q. Yuan, M. Koffas, R.J. Linhardt, Expression of low
endotoxin 3-O-sulfotransferase in Bacillus subtilis, Applied Biochemistry and Biotechnology, 171,
954–962, 2013.
84. K. Nolan, C. Kattamuri, D. M. Luedeke, A. Deng, A. Jagpal, F. Zhang, R. J. Linhardt, A. P.
Kenny, A. M. Zorn, T. B. Thompson, Structure of Protein Related to DAN and Cerberus (PRDC):
Insights into the Mechanism of BMP Antagonism, Structure, 21, 1417–1429, 2013.
85. A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J.
Linhardt, Microanalysis of stomach cancer glycosaminoglycans, Glycoconjugate Journal, 30, 701–
707, 2013
86. X. Zhao, B. Yang, L. Li, F. Zhang, R. J. Linhardt, On-line separation and characterization of
hyaluronan oligosaccharides derived from radical depolymerization, Carbohydrate Polymers, 96,
503– 509, 2013.
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87. C. Wang, G. Wu, Y. Li, Y. Huang, F. Zhang, X. Liang, Genome Shuffling of Penicillium citrinum
for Enhanced Production of Nuclease P1. Appl Biochem Biotechnol. (2013) 170:1533–1545
88. L. Wang, H. Zhang, L. Yang, X. Liang, F. Zhang, R. J Linhardt, Structural characterization and
bioactivity of exopolysaccharide synthesized by Geobacillus sp. TS3-9 isolated from radioactive
radon hot spring, Appl Biochem Biotechnol., 2013, in press.
89. J. J. Ziarek, C. T. Veldkamp, F. Zhang, N. J. Murray, G. A. Kartz, X. Liang, J. Su, J. E. Baker1, R.
J. Linhardt, and B. F. Volkman, Heparin oligosaccharides inhibit chemokine (C-X-C motif) ligand
12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting
oligomerization, and competing with the chemokine (C-X-C motif) receptor 4 (CXCR4) amino-
terminus, Journal of Biological Chemistry, 288(1):737-46, 2013.
90. A. Weyers, B.Yang, K. Solakyildirim, V.Yee, F. Zhang, R. Linhardt, Extraction and Protein
Binding Interactions of Keratan Sulfate from Bovine Cornea, FEBS Journal, 280: 2285–2293 ,
2013.
91. X. Zhao, B. Yang, K. Linkens, P. Datta, A. Onishi, F. Zhang, R. J. Linhardt, Microscale separation
of heparosan, heparan sulfate and heparin, Analytical Biochemistry, 434(2):215-7, 2013.
92. L. Li, F. Zhang, J. Zaia, R. J. Linhardt, Top-down approach for the direct characterization of low
molecular weight heparins using LC-FT-MS, Analytical Chemistry, 84, 8822−8829, 2012.
93. S. Kwon, K. Lee, K. Solakyildirim, S. Masuko, M. Ly, F. Zhang, L. Li, J. S. Dordick, R. J.
Linhardt, Ultrasensitive carbohydrate detection by Glyco-qPCR amplification and applications in
glycobiology, Angewandte Chemie, 51(47):11800-4, 2012
94. F. Zhang, J. M. Beaudet, D. M. Luedeke, R. G. Walker, T. B Thompson and R. J. Linhardt,
Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using
Surface Plasmon Resonance, Biochemistry, 51(34):6797-803, 2012.
95. J. Miao, F. Zhang, T. Majde, S. Mousa, R. J. Linhardt, Study of adsorption of doxorubicin using
PMMA-chitosan-heparin coated Ukraine activated carbon beads, Langmuir, 28:4396-403, 2012.
96. X. Zhao,B.Yang, P. Datta, L. Gasmili, F. Zhang and R. J. Linhardt, Cell-Based Microscale
Isolation of Glycoaminoglycans for Glycomics Study, Journal of Carbohydrate Chemistry, Vol. 31
(4-6): 420-435, 2012.
97. J. Baik, L. Gasimli, B. Yang, P. Datta, F. Zhang, C. A. Glass, J. D. Esko, R. J. Linhardt, S.T.
Sharfstein, Metabolic Engineering of CHO to make haparan sulfate. Metabolic Engineering, 14,
81–90, 2012.
98. Bhaskar, E. Sterner, A. M. Hickey, A. Onishi, F. Zhang, J. S. Dordick, R.J. Linhardt, Engineering
of routes to heparin and related polysaccharides, Applied Microbiology and Biotechnology, 93:1–
16, 2012
99. Z. Wang, F. Zhang, J. S. Dordick, R. J. Linhardt, Molecular weight characterization for
glycosaminoglycans with different degrees of sulfation by size exclusion chromatography, Current
Analytical Chemistry, in press, 2012.
100. F. Zhang, X. Liang, D. Pu, S. Walsh and R. J. Linhardt, Biophysical Characterization of
Glycosaminoglycan-IL-7 Interactions using SPR. Biochimie 94, 242-249, 2012. (corresponding
author) 101. A.Weyers, B. Yang, D.Yoon, J. Park, K. Lee, F. Zhang, and R. J. Linhardt. Structural Analysis
of Glycosaminoglycans from Lethal and Non-Lethal Breast Cancer Tissues, Omics, 16, 79-90,
2012.
102. C. Cai, K. Solakyildirim, B. Yang, J.M. Beaudet, A. Weyer, R. J. Linhardt and F. Zhang.
Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A. Carbohydrate Polymers 87,
822– 829, 2012. (corresponding author)
103. W. Zhao, F. Zhang, R. J. Linhardt, Optimal sequence size for heparin binding to vascular
endothelial growth factor (VEGF165), Bioscience Report, 32, 71–81, 2012
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104. F. Zhang, B.Yang, M. Ly, K. Solakyildirim, Z. Xiao, Z. Wang, Y. Chang, J. S. Dordick and
R.J. Linhardt. Chemical structure characterization of commercial heparin from different
commercial sources, Analytical and Bioanalytical Chemistry, 401, 2793-2803, 2011.
(corresponding author) 105. Wang Z, Li J, Cheong S, Bhaskar U, Akihiro O, Zhang F, Dordick JS, Linhardt RJ. Response
surface optimization of the heparosan N-deacetylation for producing bioengineered heparin. J
Biotechnol. 156, 188– 196, 2011.
106. Masuko S, Higashi K, Wang Z, Bhaskar U, Hickey AM, Zhang F, Toida T, Dordick JS,
Linhardt RJ. Ozonolysis of the double bond of the unsaturated uronate residue in low-molecular-
weight heparin and K5 heparosan. Carbohydr Res. 27;346(13):1962-6, 2011
107. H.G.Garg, H. Mrabat1, L. Yu, C.A. Hales, B. Li, C.N. Moore, F. Zhang and R. J. Linhardt.
Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine
pulmonary artery smooth muscle cells. Glycoconjugate Journal, 28(6):419-26, 2011
108. Higashi K, Ly M, Wang Z, Masuko S, Bhaskar U, Sterner E, Zhang F, Toida T, Dordick JS,
Linhardt RJ.Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered
Heparin Precursor. Carbohydr Polym. 1;86(3):1365-1370, 2011
109. B. Yang, A.Weyers, J. Baik, E. Sterner, S. Sharfstein, S. A. Mousa, F. Zhang, J. S. Dordick, R.
J. Linhardt, Ultraperformance ion-pairing liquid chromatography with on-line electrospray ion trap
mass spectrometry for heparin disaccharide analysis, Anal Biochem. Aug 1;415(1):59-66, 2011.
110. J. Beaudet, A. Weyers, K. Solakyildirim, B. Yang, S. Mousa, F. Zhang and R. J. Linhardt,
The Effect of Autoclave on the Activity of Pharmaceutical Heparin, Journal of Pharmaceutical
Science, 2011, Journal of Pharmaceutical Sciences. 100, 3396–3404, 2011 (corresponding
author) 111. G. Anand, F, Zhang, R. J. Linhardt, G. Belfort, Protein-associated water effects the removal of
blood proteins from metallic substrates, Langmuir, Mar 1;27(5):1830-6, 2011
112. W. Zhong, Y. Li, K. Sun, F. Zhang, J. Jing, J. Chen, Aerobic degradation of methyl tert-butyl
ether in a symbiosis system with mixed culture of Chlorella ellipsoidea and Methylibium
petroleiphilum PM1, Journal of Hazard Materials. 185, 1249-1255, 2011.
113. Z. Liu, Z. Xiao, S. Masuko, W. Zhao E. Sterner, F. Zhang and R. J. Linhardt, Mass Balance
Analysis of Contaminated Heparin Product, Analytical Biochemistry, 408, 147–156, 2011.
(corresponding author) 114. W. Zhong, B.Wu, W. Wang, L. Zhong, Y. Li, F. Zhang, Coenzyme Q10 production by
Sphingomonas sp. ZUTE03 with transformation-extraction coupled process, Appl. Microbiol.
Biotechnol. 89(2):293-30, 2011.
115. M. Ly, Z. Wang, T. N. Laremore, F. Zhang, W. Zhong, D. Pu, D. V. Zagorevski, J. S. Dordick,
R. J. Linhardt, Analysis of E. coli K5 capsular polysaccharide heparosan, Analytical and
Bioanalytical Chemistry, Jan;399(2):737-45, 2011.
116. Z. Liu, S. Masuko, K. Solakyildirim, D. Pu , F. Zhang, R. J. Linhardt, Glycosaminoglycans of
the porcine central nervous system, Biochemistry, Vol. 49, No. 45, 2010. (corresponding author)
117. H.G. Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Effect
of Carboxyl-Reduced Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth
Muscle Cells, Carbohydrate Research, 345, 1084–1087, 2010
118. Z. Wang, M. Ly, F. Zhang, W. Zhong, A. Suen, J. S. Dordick, R. J. Linhardt, E. coli K5
fermentation and the preparation of heparosan, a bioengineered heparin precursor, Biotechnology
and Bioengineering, Vol. 107, No. 6, 2010.
119. T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Recent progress and
applications in glycosaminoglycan and heparin research, Current Opinions in Chemical Biology,
13:1-8, 2009.
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120. H. Ra, S. Harju-Baker, F. Zhang, Robert J. Lindardt, C. L. Wilson, W. C. Parks. Activation of
promatrilysin (mmp7) and control of substrate-specific activity by sulfated glycosaminoglycans.
Journal of Biological Chemistry, 284: 27924–27932, 2009.
121. J. Han, F. Zhang, J. Xie, R. J. Linhardt and L. M. Hiebert, Changes in cultured endothelial cell
glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin,"
Cardiovascular Diabetology, 8, 46-58, 2009.
122. F. Zhang, Z. Zhang, X. Lin, A. Beenken, M. Mohammadi and R. J. Linhardt. Structural
analysis on heparin/heparan sulfate interacting with FGF•FGFR complexes, Biochemistry, 48,
8379–8386, 2009. (corresponding author)
123. J. Suwan, Z. Zhang, B. Li, P. Vongchan, P. Meepowpan, F. Zhang, S.A. Mousa, S. Mousa, B.
Premanode, P. Kongtawelert, R. J. Linhardt, Sulfonation of papain treated chitosan and its
mechanism for anticoagulant activity, Carbohydrate Research, 344: 1190–1196, 2009.
124. B. Li, J.Suwan, J.G. Martin, F. Zhang, Z. Zhang, D. Hoppensteadt, M. Clark, J. Fareed, R.J.
Linhardt, Oversulfated chondroitin sulfate interaction with heparin-binding proteins: New insights
into adverse reactions from contaminated heparins, Biochemical Pharmacology, 78: 292–300,
2009.
125. I. G. Sava, F. Zhang, I. Toma, C. Theilacker, B. Li, T. F. Baumert, O. Holst, R. J. Linhardt, J.
Huebner, Novel Interactions of Glycosaminoglycans and Bacterial Glycolipids Mediate Binding of
Enterococci to Human Cells, Journal of Biological Chemistry, 284: 18194–18201, 2009.
126. Z. Zhang, B. Li, J. Suwan, F. Zhang, Z. Wang, H. Liu, B. Mulloy, R. J. Linhardt, Analysis of
pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE, Journal of
Pharmaceutical Science, 98, 4017-4026, 2009.
127. F. Zhang, Z. Zhang, R. Thistle, L. McKeen, S. Hosoyama, T. Toida, R. J. Linhardt, P. Page-
McCaw, Structural Characterization of Glycosaminoglycans from Zebrafish in Different Ages,
Glycoconjugate Journal, 26:211–218, 2009.
128. H. G.Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales,
Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth
Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells, Carbohydrate Research, 343,
2406−2410, 2008.
129. S. Bhattacharyya, R. Gill, M. Chen, F. Zhang, R. J. Linhardt, P. K. Dudeja, J. K. Tobacman,
Toll-like Receptor 4 Mediates Induction of Inflammatory Pathway by Food Additive Carrageenan,
Journal of Biological Chemistry 283, 10550-10558, 2008.
130. M. Warda, F. Zhang, M. Radwan, Z. Zhang, R. J. Linhardt, H. Jin, Is Human Placenta
Proteoglycan Remodeling Involved in Pre-Eclampsia? Glycoconjugate Journal, 25, 441–450,
2008.
131. R. Copeland, A. Balasubramaniam, V. Tiwari, F. Zhang, A. Bridges, R. J. Linhardt, D. Shukla,
J. Liu, Using a 3-O-Sulfated Heparan Sulfate Octasaccharide to Inhibit the Entry of Herpes
Simplex Virus 1, Biochemistry, 47, 5774–5783, 2008.
132. J. Nam, F. Zhang, M. Ermonval, R. J. Linhardt and S. T. Sharfstein, The effects of culture
conditions on the glycosylation of secreted human placental alkaline phosphatase produced in
Chinese hamster ovary cells. Biotechnology and Bioengineering, 100, 1178-1192, 2008.
133. Z. Zhang, J. Xie, F. Zhang and R. J. Linhardt, Thin Layer Chromatography for the Analysis of
Glycosaminoglycan Oligosaccharides. Analytical Biochemistry, 371, 118-120, 2007.
134. S. A. Mousa, F. Zhang, A. Aljada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, E. Arbit,
M. C. Castelli, M.M. Goldberg, R. J. Linhardt, Pharmacokinetic and Pharmacodynamic of Oral
Heparin Solid Dosage Form in Healthy Human Subjects. Clinical Pharmacology, 47, 1508-1520,
2007.
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135. F. Zhang, J. S. McLellan, A. M. A. Jiménez, D. J. Leahy, R. J. Linhardt, Kinetic and Structural
Studies on Interactions between Heparin/Heparan Sulfate and Proteins of the Hedgehog Signaling
Pathway, Biochemistry, 46, 3933-3941, 2007. (corresponding author and Hot Article of the
Month)
136. R. Goetz, A. Beenken, O. A. Ibrahimi1, J. Kalinina1, S. K. Olsen1, A. V. Eliseenkova, C. F.
Xu, T. Neubert, F. Zhang, R. J. Linhardt, X. Yu, K. E. White, T. Inagaki, S. A. Kliewer, M.
Yamamoto, H. Kurosu, Y. Ogawa, M. Kuro-o, B. Lanske, M. S. Razzaque, M. Mohammadi,
Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily
Members, Molecular and Cellular Biology, 27, 3417-3428, 2007.
137. Shaker A. Mousa, Haifeng Zhang, Ahmad Aljada, Fuming Zhang, Ehud Arbit, Lewis Bender,
Michael Goldberg, and Robert Linhardt. Pharmacokinetics and Pharmacodynamics of Oral Heparin
Solid Dosage Form in Healthy Human Subjects. Blood, 110: 4009, 2007.
138. T.N. Laremore, F. Zhang, R. J. Linhardt, New Ionic Liquid Matrix for Direct UV-MALDI-
TOF-MS Analysis of Dermatan Sulfate and Chondroitin Sulfate Oligosaccharides, Analytical
Chemistry, 79, 1604-1610, 2007.
139. C. Shao, F. Zhang, R. J. Linhardt, J. F. Head, B. Seaton, Crystallographic Analysis of
Calcium-Dependent Heparin Binding to Annexin A2, Journal of Biological Chemistry, 281,
31689–31695, 2006.
140. H. Barth, E. K. Schnober, F. Zhang, R. J. Linhardt, E. Depla, B. Boson, F.-L. Cosset, A. Patel,
H. E. Blum, T. F. Baumert, Viral and Cellular Determinants of Hepatitis C Virus Envelope-
Heparan Sulfate Interaction, Journal of Virology, 80, 10579-10590, 2006.
141. M. Warda, T. Toida, F. Zhang, P. Sun, E. Munoz, R. J. Linhardt, Isolation and
Characterization of Heparan Sulfate from Various Murine Tissues, Glycoconjugate Journal, 23,
553-561, 2006.
142. E. Munoz, D. Xu, M. Kemp, F. Zhang, J. Liu, R. J. Linhardt, Affinity, Kinetic, and
Structural Study of the Interaction of 3-O-Sulfotransferase Isoform 1 with Heparan Sulfate,
Biochemistry, 45, 5122-5128, 2006.
143. B. Daniels, R.J. Linhardt, F. Zhang, W. Mao, S. Wice, L. Hiebert, In Vivo Antithrombotic
Synergy of Oral Heparin and Arginine: Endothelial Thromboresistance Without Systemic
Anticoagulation, Thrombosis and Haemostasis, 95, 865-72, 2006.
144. F. Zhang, P. Sun, E. Muñoz, L.Chi, S. Sakai, T. Toida, R. J. Linhardt, Microscale Isolation and
Analysis of Heparin from Plasma using an Anion Exchange Spin Column, Analytical Biochemistry,
353, 284-286, 2006.
145. J. Y. Suk, F. Zhang, W. E. Balch, R. J. Linhardt, J. W. Kelly, Heparin Accelerates Gelsolin
Amyloidogenesis, Biochemistry, 45, 2234-2242, 2006.
146. Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, Garringer HJ, Linhardt RJ, Ornitz DM,
Mohammadi M, White KE, Analysis of the biochemical mechanisms for the endocrine actions of
FGF23., Journal of Bone and Mineral Research 20 (9): S27, Suppl. 1, 2005.
147. S. K. Olsen, J.Y.H. Li, C. Bromleigh, A.V. Eliseenkova, O. A. Ibrahimi, Z. Lao, F. Zhang, R. J.
Linhardt, A. L. Joyner and M. Mohammadi, Structural Basis by Which Alternative Slicing
Modulates the Biological Activity of FGF8, Genes and Development, 20, 185-198, 2006.
148. X. Yu, O. A. Ibrahimi, F. Zhang, S. I. Davis, H. J. Garringer, R. J. Linhardt, D. M. Ornitz, M.
Mohammadi, and K. E. White. Analysis of the Biochemical Mechanisms for the Endocrine
Actions of FGF23. Endocrinology. 146, 4647-56, 2005.
149. O.A. Ibrahimi, B.K. Yeh, A.V. Eliseenkova, F. Zhang, S.K. Olsen, M. Igarashi, S.A.
Aaronson, R.J. Linhardt, M. Mohammadi, Analysis of Mutations in FGF and a Pathogenic
Mutation in FGFR Provide Direct Evidence in Support of the Two-End Model for FGFR
Dimerization. Molecular & Cellular Biology, 25, 671-684, 2005.
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150. Omar A. Ibrahimi, Fuming Zhang, Anna V. Eliseenkova, Nobuyuki Itoh, Robert J. Linhardt,
and Moosa Mohammadi. Biochemical Analysis of Pathogenic Ligand-dependent FGFR2
Mutations Suggests Distinct Pathophysiological Mechanisms for Craniofacial and Limb
Abnormalities in Human Skeletal Disorders. Human Molecular Genetics, 13, 2313 – 2324, 2004.
151. F. Zhang, A. D. Bries, S.C. Lang, Q. Wang, J.M. Weiler, R.J. Linhardt, Metabolic Alteration
of the N-Glycan Structure of a Protein from Patients with a Heterozygous Protein Deficiency.
Biochimica Biophysica Acta, 1739, 43-49, 2004.
152. F. Zhang, Y. Wu, Q. Ma, D. Hoppensteadt, J. Fareed, R. J. Linhardt, Studies on the effect of
calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance.
Clinical and Applied Thrombosis/Hemostasis, 10, 249-257, 2004.
153. O. A. Ibrahimi, F. Zhang, S. C. Lang Hrstka, M. Mohammadi, R. J. Linhardt, A Kinetic Model
for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly, Biochemistry, 43,
4724-4730, 2004.
154. F. Zhang, F. Ronca, R.J. Linhardt, R.U. Margolis, Structural Determinants of Heparan Sulfate
Interactions With Slit Proteins. Biochemical Biophysical Research Communications, 317, 352-
357, 2004.
155. F. C. Peterson, E. S. Elgin, T. J. Nelson, F. Zhang, T. J. Hoeger, R. J. Linhardt, B. F. Volkman,
A Glycosaminoglycan Recognition Element of Lymphotactin Essential for In Vivo Chemokine
Activity. Journal of Biological Chemistry, 279, 12598-12604, 2004.
156. S. K. Olsen, O. A. Ibrahimi, A. Raucci, F. Zhang, A. V. Eliseenkova, A. Yayon, C. Basilico,
R. J. Linhardt, J. Schlessinger, M. Mohammadi, Insights Into the Molecular Basis for FGF
Receptor Autoinhibition and Ligand binding Promiscuity. Proceedings of the National Academy of
Sciences USA, 101, 935-940, 2004.
157. O.A. Ibrahimi, F. Zhang, A. V. Eliseenkova, R. J. Linhardt, M. Mohammadi, Proline to
Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis
Syndromes Through the Enhancement of FGF Binding Affinity. Human Molecular Genetics, 13,
69-78, 2004.
158. H. Barth, C. Schäfer, M.I. Adah, F. Zhang, R.J. Linhardt, H. Toyoda, A. Kinoshita-Toyoda, T.
Toida, T. H. van Kuppevelt, E. Depla, F. von Weizsäcker, H.E. Blum, T.F. Baumert, Cellular
Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate.
Journal of Biological Chemistry, 278, 41003 – 41012, 2003.
159. F. Zhang, A. M. Fath, R. Marks and R. J. Linhardt, A Highly Stable Covalent Conjugated
Heparin Biochip for Heparin-Protein Interaction Studies. Analytical Biochemistry. 304, 271-273,
2002.
160. F. Zhang, D. W. Murhammer and R. J. Linhardt, Kinetic and Glycan Structure
Characterization of Secreted Alkaline Phosphatase from the Baculovirus Expression Vector
System. Applied Biochemistry and Biotechnology, 101, 197-210, 2002.
161. F. Zhang, M. A. Saarinen, D. W. Murhammer and R. J. Linhardt, The Effect of Dissolved
Oxygen (DO) Concentration on the Glycosylation of Recombinant Protein Produced by the Insect
Cell-Baculovirus Expression System. Biotechnology and Bioengineering, 77, 219-224, 2002.
162. W.M. Wolff, F. Zhang, D. W. Murhammer, R. J. Linhardt and J. M. Weiler, Expression of C1
Esterase Inhibitor by the Baculovirus Expression Vector System: Preparation, Purification and
Characterization. Protein Expression and Purification. 22, 414-421, 2001.
163. F. Zhang, Wolff W. M., Murhammer D. W. and Linhardt R. J. Affinity Purification of
Secreted Alkaline Phosphatase Produced by the Baculovirus Expression Vector System. Applied
Biochemistry and Biotechnology, 90, 125-136, 2001.
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164. J. S. Knapp, E. J. Vantoch-Wood, and F. Zhang, Use of Wood-Rotting Fungi for the
Decolourisation of Dyes and Industrial Effluents. Editor: Gadd, G. M. Fungi in Bioremediation.
Cambridge University Press. 2001,
165. J. Choe, F. Zhang, W. M. Wolff, R. J. Linhardt and J. S. Dordick, Separation of AGP
Glycoforms Using Affinity-Based Reverse Micellar Extraction and Separation. Biotechnology and
Bioengineering, 70, 484-490, 2000.
166. F. Zhang and J. Yu, Decolourisation of Acid Violet 7 with Complex pellets of White Rot
Fungus and Activated Carbon. Bioprocess Engineering, 23, 295-301, 2000.
167. F. Zhang, J. S. Knapp and K. N Tapley, Development of Bioreactor Systems for
Decolourisation of Orange II Using Wood Rotting Fungus. Enzyme and Microbial Technology, 24,
48-53, 1999.
168. F. Zhang, J. S. Knapp and K. N. Tapley, The Treatment of Cotton Bleaching Effluent with
Wood Rotting fungus. Water Research, 33, 919-928, 1999.
169. F. Zhang, J. S. Knapp and K. N. Tapley, Development of Bioreactor Systems for
Decolourisation of Cotton Bleaching Effluent by Wood Rotting Fungus. Biotechnology Letters, 20,
717-723, 1998.
170. F. Zhang, The Treatment of Coloured Effluents with Wood Rotting Fungi. PhD thesis. The
University of Leeds, 1997.
171. J. S. Knapp, F. Zhang and K. N. Tapley, Decolourisation of Orange II by a Wood Rotting
Fungus. Journal of Chemical Technology and Biotechnology, 69, 289-296, 1997.
172. B. Yu, F.Zhang, P. Wang and Y. Zhen, Alcohol Fermentation from the Mash of Dried Sweet
Potato with Its Dregs Using Immobilized Yeast. Process Biochemistry, 31, 1-6, 1996.
173. B. Yu, F. Zhang and P. Wang, Study on the Production of L-Malic Acid by Bioconversion:
Screening of Fumarase Producing Strains. Food and Fermentation Industries (Ch), 1, 18-23, 1996.
174. B. Yu, F.Zhang, P. Wang and Y. Zhen, Alcohol Fermentation Using Thin-slice Packed Bed
Bioreactor by Immobilized Yeast Cells. Industrial Microbiology (Ch), 3, 24-28, 1995.
175. B. Yu, F.Zhang, P. Wang and Y. Zhen, Scale-up Research on Alcoholic Fermentation from
Dried Sweet Potato by Immobilized Yeast. Food and Fermentation Industries (Ch), 2, 1-6, 1994.
176. B. Yu, F.Zhang, Production of Ethanol by Fermentation of Dried Sweet Potato with
Immobilized Yeast Cells. Chinese Journal of Biotechnology, 9, 1, 24-29, 1993.
177. B. Yu, F.Zhang, Studies on Inhibitory Factors in Lactic Acid Fermentation. Journal of
Zhejiang University of Technology (Ch), 1, 58-64, 1992.
178. B. Yu, F.Zhang, P. Wang, Study on Production of Ethanol by Fermentation of the Mash of
Dried Sweet Potato Using Immobilized Yeast Cells. Food and Fermentation Industries (Ch), 4, 1-
7, 1991.
179. B. Yu, F.Zhang, and P. Wang, Study on Latic Acid Fermentation Using Immobilized Cells.
Journal of Zhejiang University of Technology (Ch), 3, 9-15, 1991.
180. B. Yu, F.Zhang, P. Wang, Screening and Mutagenic Treatment of D-isoascorbic Acid
Producing Strains. Journal of Zhejiang University of Technology (Ch), 1, 1-7, 1991.
181. B. Yu, F.Zhang, Production of D-isoascorbic Acid (iso-vitamin C) and Its Application in Food
Processes. Hangzhou Food Science (Ch), 1, 1-4, 1991.
182. B. Yu, F.Zhang, Study on Strains, Carriers and Multiplication Processes Used in Ethanolic
Fermentation of Dried Sweet Potato by Immobilized Yeast Cells. Journal of Zhejiang University of
Technology (Ch), 1, 31-39, 1991.
183. B. Yu, F.Zhang, Production of Ethanol by Fermentation of Dried Sweet Potato with Low
Temperature Cooking Process and Immobilized Yeast Cells. Journal of Zhejiang University of
Technology (Ch), 1, 24-29, 1990.
F. ZHANG
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BOOK CHAPTERS
1. Shujuan Zhao, Zhengtao Wang, Mattheos Koffas, Robert J. Linhardt and Fuming Zhang,
Phenylethanoid glycosides, Recent Progress in Medicinal Plantsby Studium Press LLC, USA,
2016.
2. F. Zhang, Z. Zhang, R.J. Linhardt, Handbook of Glycomics, Chapter 2: Glycoconjugate
Structural Analysis, 2d. Glycosaminoglycan. 2009.
3. F. Zhang, P.G. Yoder, R.J. Linhardt, Synthetic and Natural Polysaccharides with
Anticoagulant Properties. in Polysaccharides: Structural Diversity and Functional Versatility,
2nd Edition, S. Dumitriu, Ed., Marcel Dekker, New York, 773-794, 2004.
4. J. S. Knapp, E. J. Vantoch-Wood, and F. Zhang, Use of Wood-Rotting Fungi for the
Decolourisation of Dyes and Industrial Effluents. Editor: Gadd, G. M. Fungi in Bioremediation.
Cambridge University Press. 2001.
PUBLISHED ABSTRACTS
1. Fulcher, Yan G.; Zhang, Fuming; Linhardt, Robert J.; et al. Homogeneous, Sulfated
Oligosaccharides from Glycosaminoglycans Activate Promatrilysin (proMMP-7) Largely by
Co-localization, Conference: Joint Annual Meeting of the ASPET/BPS at Experimental
Biology (EB) Location: Boston, MA Date: APR 20-24, 2013 , Sponsor(s): ASPET; British
Pharmacol Soc (BPS). FASEB JOURNAL Volume: 27 Meeting Abstract: 1015.3 Published:
APR 2013
2. Weyers, Amanda; Yang, Bo; Gasimli, Leyla; Zhang, Fuming; Linhardt, Robert J. et al.
Structure and Expression of Glycosaminoglycans in Cancerous Tissue, Conference: Joint
Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology Location:
San Diego, CA Date: NOV 11-14, 2012, Sponsor(s): Soc Glycobiol; Amer Soc Matrix Biol,
GLYCOBIOLOGY Volume: 22 Issue: 11 Pages: 1646-1646 Published: NOV 2012
3. Aguilera, J. Javier; Srinivasan, Sai; Beaudet, Julie; Zhang, Fuming; Linhardt, Robert J.; et al.
Glycosaminoglycan-dependent oligomerization and fibrillogenesis of serum amyloid A,
Conference: 244th National Fall Meeting of the American-Chemical-Society (ACS) Location:
Philadelphia, PA Date: AUG 19-23, 2012, Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer
Chem Soc. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Volume: 244 Meeting Abstract: 30-CARB Published: AUG 19 2012
4. Beaudet, Julie M.; Lee, Yu Jin; Shastry, Divya; et al.Effects of metal ion concentrations on
fibroblast growth factor binding to heparin, Conference: 244th National Fall Meeting of the
American-Chemical-Society (ACS) Location: Philadelphia, PA Date: AUG 19-23, 2012
Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer Chem Soc, ABSTRACTS OF PAPERS
OF THE AMERICAN CHEMICAL SOCIETY Volume: 244 Meeting Abstract: 26-CARB
Published: AUG 19 2012
5. Bhaskar, Ujjwal J.; Onishi, Akihiro; Sterner, Eric; et al.Controlling sulfation pattern to prepare
a safer bioengineered heparin, Conference: 244th National Fall Meeting of the American-
Chemical-Society (ACS) Location: Philadelphia, PA Date: AUG 19-23, 2012 , Sponsor(s):
Amer Chem Soc, Div Hist Chem; Amer Chem Soc, ABSTRACTS OF PAPERS OF THE
AMERICAN CHEMICAL SOCIETY Volume: 244 Meeting Abstract: 63-CARB Published:
AUG 19 2012
F. ZHANG
15
6. Datta, Payel; Gasimli, Leyla; Zhao, Xue; Zhang, Fuming; Linhardt, Robert J.; et al.Synthesis of
bioengineered heparin in mammalian cell lines, Conference: 244th National Fall Meeting of
the American-Chemical-Society (ACS) Location: Philadelphia, PA Date: AUG 19-23, 2012
Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer Chem Soc, ABSTRACTS OF PAPERS
OF THE AMERICAN CHEMICAL SOCIETY Volume: 244 Meeting Abstract: 18-CARB
Published: AUG 19 2012
7. Weyers, Amanda; Yang, Bo; Yoon, Dae Sung; Zhang, Fuming; Linhardt, Robert J.; et al.
Structural analysis of glycosaminoglycans in breast cancer tissue, Conference: 244th National
Fall Meeting of the American-Chemical-Society (ACS) Location: Philadelphia, PA Date: AUG
19-23, 2012, Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer Chem Soc, ABSTRACTS
OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 244 Meeting Abstract:
59-CARB Published: AUG 19 2012
8. Zhang, Fuming; Linhardt, Robert J.Glycobiology/glycomics research using SPR biosensors
Conference: 244th National Fall Meeting of the American-Chemical-Society (ACS) Location:
Philadelphia, PA Date: AUG 19-23, 2012, Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer
Chem Soc, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Volume: 244 Meeting Abstract: 61-CARB Published: AUG 19 2012
9. Zhao, Xue; Yang, Bo; Zhang, Fuming; et al.Cell based microscale isolation of
glycoaminoglycans for glycomics study. Conference: 244th National Fall Meeting of the
American-Chemical-Society (ACS) Location: Philadelphia, PA Date: AUG 19-23, 2012,
Sponsor(s): Amer Chem Soc, Div Hist Chem; Amer Chem Soc, ABSTRACTS OF PAPERS
OF THE AMERICAN CHEMICAL SOCIETY Volume: 244 Meeting Abstract: 19-CARB
Published: AUG 19 2012
10. Van Doren, Steven R.; Fulcher, Yan; Byrne, Todd; et al. Exosites, Allostery, & Active Site in
MMP Engagement of Elastin, Collagen, and Heparin from the Matrix Conference:
Experimental Biology Meeting Location: San Diego, CA Date: APR 21-25, 2012, FASEB
JOURNAL Volume: 26 Published: APR 2012
11. H. Barth, E. K. Schnober, Zhang F, R. J. Linhardt, E. Depla, B. Boson, F.-L. Cosset, A. Patel,
H. E. Blum, T. F. Baumert, Targeting of hepatitis C virus-heparan sulfate by human anti-viral
antibodies, Journal of Clinical Virology 36: S113-S113 Suppl. 2, 2006.
12. Barth H, Schnober EK, Zhang F, Linhardt RJ, Depla E, Boson B, Cosset F, Patel A, Blum HE
, Baumert TF, Viral and cellular determinants of hepatitis C virus envelope-heparan sulfate
interaction, Journal of Hepatology 44: S152-S152 402 Suppl. 2, 2006.
13. Zhang FM, Hrstka SCL, Yu H, et al. Interaction studies between heparin and proteins of
biological importance using surface plasmon resonance. Abstracts of Papers of the American
Chemical Society 226: U190-U190 235-BIOL Part 1 SEP 2003.
14. Zhang FM, Warda M, Baumert TF, et al. Study on the interaction between heparin and virus
envelope proteins using SPR. Abstracts of Papers of the American Chemical Society 226:
U201-U201 009-CARB Part 1, 2003.
15. Zhang FM, Hrstka SCL, Yu HN, Edens E, Linhardt RJ Studies of the interaction between
heparin and proteins of biological importance using surface plasmon resonance. Abstracts of
Papers of the American Chemical Society 224: 109-BIOT Part 1 2003.
16. Zhang FM, Linhardt RJ Study on the interaction between heparin and proteins with biological
significant using SPR. Abstracts of Papers of the American Chemical Society 224: 109-BIOT
Part 1 AUG 18 2002.
17. Linhardt RJ, Zhang FM, Lang SC, et al. Metabolic alteration of the N-glycan structure of C1
esterase inhibitor in patients with hereditary angioedema. Abstracts of Papers of the American
Chemical Society, 222: 72-CARB Part 1 AUG 2001.
F. ZHANG
16
PATENT
1. “Controlled Photochemical Depolymerization of K5 Heparosan," T. Toida, R. J. Linhardt, J. S.
Dordick, K.Higashi, Z. Wang, U. Bhaskar, M. Ly, F. Zhang, U.S. Patent Pending
2. “Biotransformation of heparan sulfate from chicken egg shells to heparin” R. J. Linhardt, Z.
Liu, F. Zhang, L. Li, W. He, J. S. Dordick, Patent Pending
INTERNATIONAL CONFERENCE PRESENTATIONS
1. 7 LAKES PROTEOGLYCANS CONFERENCE GAGs Based Glycomics/interactome Research
Using SPR. Fuming Zhang, Robert J. Linhardt, Varese, Italy 10-14 September 2017, Oral.
2. 254th ACS National Meeting, Fuming Zhang, So-Young Kim, Jing Zhao, Robert Linhardt: GAGs
glycomics/interactome research using SPR, oral, August 20-24, 2017 - Washington, DC.
3. 254th ACS National Meeting, Lanhong Zheng, Daole Kang, Fuming Zhang, Robert Linhardt:
Cytotoxicity β-glucanase NCBG purified from Bacillus sp. screened from Antarctic Sea, Poster, August
20-24, 2017 - Washington, DC.
4. 254th ACS National Meeting, Peipei wang, Yongxi Pan, Xing Zhang, Fuming Zhang, Robert
Linhardt: Synthesis of multivalent lactose-based dendrimers and their antitumor activity by targeting
galectin-, Poster, August 20-24, 2017 - Washington, DC.
5. 254th ACS National Meeting, Yanlei Yu, Hong Zhang, Fuming Zhang, Robert Linhardt: Sequence
determination of decorin glycosaminoglycan chains, Poster, August 20-24, 2017 - Washington, DC.
6. 254th ACS National Meeting, Guoqiang Xu, Fuming Zhang, Mattheos Koffas, Robert Linhardt:
Improvement of fumaric acid biosynthesis in engineered Saccharomyces cerevisiae by site-directed
mutagenesis and codon optimization, oral, August 20-24, 2017 - Washington, DC.
7. BIAcore International Symposium 2011 (DiPIA 2016), Fuming Zhang and Robert J. Linhardt,
Glycomics research using SPR biosensors, poster, September, 2016, Berlin, Germany.
8. Gordon Research Conference: Proteoglycans, Proctor Academy, Kinetics and Structural Analysis on
the Interaction between Heparin/GAGs and Langerin, July, 2016, Poster.
9. 1st Southeast Glycoscience Symposium April 18th, 2015, Atlanta, GA, GAG based Glycomics
Research using SPR Biosensors, invited speaker.
10. Gordon Research Conference: Proteoglycans, Proctor Academy, July, 2014, Probing the impact of
GFP tagging on Robo1-heparin interaction using SPR, Poster.
11. Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Fulcher, Yan G.; Zhang,
Fuming; Linhardt, Robert J.; et al. Homogeneous, Sulfated Oligosaccharides from
Glycosaminoglycans Activate Promatrilysin (proMMP-7) Largely by Co-localization, Conference:
Location: Boston, MA Date: APR 20-24, 2013 ,
12. Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology Weyers,
Amanda; Yang, Bo; Gasimli, Leyla; Zhang, Fuming; Linhardt, Robert J. et al. Structure and
Expression of Glycosaminoglycans in Cancerous Tissue, Location: San Diego, CA Date: NOV 11-
14, 2012.
13. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Controlling sulfation pattern to prepare a safer bioengineered heparin, U. J. Bhaskar, A.
Onishi, E. Sterner, F. Zhang, J. Liu, J. S. Dordick, R. J. Linhardt , Oral presentation.
F. ZHANG
17
14. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Glycobiology/glycomics research using SPR biosensors, F. Zhang, R. J. Linhardt, Oral
presentation.
15. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Structural analysis of glycosaminoglycans in breast cancer tissue, A. Weyers, B. Yang, D. S.
Yoon, J. Park, F. Zhang, K. B. Lee, R. Linhardt, Oral presentation.
16. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Glycosaminoglycan-dependent oligomerization and fibrillogenesis of serum amyloid A , J.
Javier Aguilera, S. Srinivasan, J. Beaudet, S. Masuko, F. Zhang, R. J. Linhardt, W. Colón, Poster.
17. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Effects of metal ion concentrations on fibroblast growth factor binding to heparin. Julie M.
Beaudet, Yu Jin Lee, Divya Shastry, , F. Zhang, R. J. Linhardt, Poster.
18. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Cell based microscale isolation of glycoaminoglycans for glycomics study , X. Zhao, B. Yang,
F. Zhang, P. Dutta, L. Gasmili, R. J. Linhardt, Poster.
19. The 242nd
American Chemical Society (ACS) Fall National Meeting, Philadelphia, PA, August,
2012, Synthesis of bioengineered heparin in mammalian cell lines , P. Datta, L. Gasimli, X. Zhao, B.
Yang, J. Y. Baik, C. A. Glass, J. D. Esko, F. Zhang, S. T. Sharfstein, R. J. Linhardt, Poster.
20. BIAcore International Symposium 2011 (DiPIA 2011), Surface Plasmon Resonance in Glycomic
Research, Boston, 11/2011, poster
21. Gordon Research Conference: Proteoglycans, Proctor Academy, July, 2012, Analysis of the
Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using SPR, Poster.
22. 7th Midwest Carbohydrate and Glycobiology Symposium, Glycobiology and Glycoengineering
Research on Heparin, 09/2011, East Lansing, MSU, invited speaker.
23. Heparin, Heparin Crisis and Future Perspective, 9th International Conference on Food Science and
Technology, Zhejiang Gongshang University, Hangzhou, P R China , May 27 - 29, 2011, Oral
presentation.
24. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Glycomics of
Glycosaminoglycans of the porcine central nervous system, Oral presentation.
25. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Preventing the
transmission of Plasmodium falciparum through the inhibition of malaria protein binding to placental
chondroitin sulfate A. Poster.
26. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Immobilization
of enzymes relevant to bioengineered heparin synthesis. Poster.
27. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Analysisof the
absorption of low molecular weight heparin in human umbilical cord tissue as a model for the
prevention of cancer metastasis. Poster.
28. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Structural and
quantitative analysis of disaccharides using CE with LIF detection. Poster.
29. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, Purification
strategies for separation of capsular polysaccharide from fermentation broth. Poster.
30. The 240nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2010, E. coli K5
heparosan production for bioengineered heparin. Poster.
31. Gordon Research Conference: Proteoglycans, Proctor Academy, July, 2010, Study of the Interaction
between Heparin and Interleukin 7 (IL-7) Using Surface Plasmon Resonance, Poster.
32. Chemo-saturation: A Novel Approach to Treat Liver Cancer. AAPS 2009 Meeting, Los Angeles,
11/2009, Poster.
F. ZHANG
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33. Current Trends in Microcalorimetry and Biacore Symposium’ 2009, Beltimore, MA. SPR analysis on
OSCS interaction with heparin-binding proteins, Poster.
34. The 238th ACS National Meeting, Washington DC, August 17-21, 2009, Biochemically engineered
heparin, Poster
35. The 238th ACS National Meeting, Washington DC, August 17-21, 2009, Redesigning the biological
activities of heparan sulfate on a microfluidic chip, Oral presentation.
36. The 238th ACS National Meeting, Washington DC, August 17-21, 2009, Analysis of pharmaceutical
heparins and potential contaminants using 1H-NMR and PAGE, Poster
37. The 238th ACS National Meeting, Washington DC, August 17-21, 2009, Application of Surface
Plasmon Resonance (SPR) in glycobiology: characterization of molecular interactions between
GAGs and proteins, Invited oral presentation.
38. Gordon Research Conference: Carbohydrates, June, 2009, Tilton. SPR analysis on OSCS interaction
with heparin-binding proteins, Poster.
39. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Biophysical
characterization on the interactions between heparin/HS and proteins with biological significant
using SPR, Oral presentation.
40. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Structural analysis on
heparin/heparan sulfate interacting with FGF•FGFR complexes, Oral presentation.
41. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Microscale enzymatic
synthesis of heparin using digital microfluidic and microarray technologies. Poster.
42. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Sulfation of Papain treated
chitosan and its anticoagulant activity, Poster.
43. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Ultrafiltration reactor for
oligosaccharide preparation from GAGs enzymatic deploymerization, Poster.
44. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, Interaction between human
Hyaluronidase-1 and glycosaminoglycans, Poster.
45. The 234nd
American Chemical Society (ACS) Fall National Meeting, Boston, 8/2007, Structural and
Kinetics Study on the Interactions between Heparin/HS and Proteins with Biological Significant
Using SPR, Boston, Oral presentation.
46. 234nd
American Chemical Society (ACS) Fall National Meeting, 8/2007, Structure and interaction
studies on follicular fluid heparan sulfate, Boston, Poster.
47. Gordon Research Conference, Carbohydrates, June, 2007, Tilton, Kinetic and Structural Studies on
Interactions between Heparin/Heparan Sulfate and Proteins of the Hedgehog Signaling Pathway,
Poster.
48. BIAcore International Symposium 2007 (DiPIA 2007), 5/2007, Pheonix, Study on the Interactions
between Heparin/HS and Proteins with Biological Significant Using SPR. Poster.
49. 232nd
American Chemical Society (ACS) Fall National Meeting, 9/2006, San Fracisco, Study on the
Interaction between Heparin/HS and Proteins in Hedgehog Signaling Pathway Using Surface
Plasmon Resonance. Oral presentation.
50. BIAcore International Symposium 2005 (DiPIA 2005), 8/2005, Philadelphia, SPR Studies on the
Molecular Interaction between FGF and FGFR. Poster.
51. BIAcore International Symposium 2005 (DiPIA 2005), 8/2005, Philadelphia, Mouse Glycomics:
SPR studies on the interaction between protein and heparan sulfate isolated from various tissues.
Poster.
52. 228nd
American Chemical Society (ACS) Fall National Meeting, 9/2004, Philadelphia, SPR Affords
A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly. Oral
presentation.
F. ZHANG
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53. 226nd
American Chemical Society (ACS) Fall National Meeting, 9/2003, New York, Study on the
Interaction between Heparin and Viral Envelope Proteins Using SPR. Oral presentation.
54. 224nd
American Chemical Society (ACS) Fall National Meeting, 8/2002, Boston, Study on the
Interaction between Heparin and Proteins with Biological Significant Using SPR. Oral presentation.
55. BIAcore International Symposium 2002, 05/2002, Chicago, Development of a Highly Stable
Covalent Conjugated Heparin Biochip for Heparin-Protein Interaction Studies. Poster.
56. American Institute of Chemical Engineers (AIChE) 2001 Annual Meeting, 11/2001, Reno. The
Effect of Dissolved Oxygen (DO) Concentration on the Glycosylation of Recombinant Protein
Produced by the Insect Cell-Baculovirus Expression System. Oral presentation
57. 222nd
American Chemical Society (ACS) Fall National Meeting, 8/2001, Chicago. Metabolic
Alteration of the N-Glycan Structure of C1 Esterase Inhibitor in Patients with Hereditary
Angioedema. Poster.
58. American Institute of Chemical Engineers (AIChE) 99 Annual Meeting, 10/1999, Dallas. Modifying
N-linked protein glycosylation in the Spodoptera frugiperda Sf-9 Insect Cell. Oral presentation.
59. International Color Chemistry Conference, 4/1998, Leeds, UK. Biodegradation of Dyes Using Wood
Rotting Fungi. Poster.
60. Society for General Microbiology, UK, 9/1997, Dublin, Ireland. Decolorization of Azo Dyes with
Wood Rotting Fungi. Poster.
61. Sino-America Bioreaction and Bioseparation Conference, 6/1992, Hangzhou, China. Production of
Ethanol by Fermentation of Dried Sweet Potato Using Immobilized Yeast Cells. Oral presentation.
INVITED PRESENTATIONS
1. Glycobiology and Glycoengineering Research on Heparin, 7th Midwest Carbohydrate and
Glycobiology Symposium, Michigan State University, East Lansing, Sept. 17th, 2011
2. From Environmental Microbiology to Glycobiology, HuaQiao University, Xiamen, China, May
30, 2011.
3. Heparin, Heparin Crisis and Future Perspective, 9th International Conference of Food Science
and Technology, Hangzhou, China, May 29th, 2011
4. Recent Progress in Glycomics. Zhejiang University of Technology, Hangzhou, China, May 27,
2011.
5. Glycobiology/glycomic Research Using Surface Plasmon Resonance, University of North
Carolina, Chapel Hill, October, 2010.
6. Research Progress in Glycobiology and Glycomics, Zhejiang University, Hangzhou, China,
April, 2010.
7. Recent Progress in Glycobiology and Glycoengineering Research. Zhejiang University of
Technology, Hangzhou, China, April, 2010.
8. The Frontier of Molecular Interaction Studies Using Surface Plasmon Resonance (SPR) in
Biotechnical and Medical Research, Chinese National Scientific Academy, Beijing, September,
2008.
9. Molecular Interaction Studies Using Surface Plasmon Resonance (SPR), Zhejiang University
of Technology, Hangzhou, China, September, 2008.
10. Glycobiology Research Using Surface Plasmon Resonance, Short Summer Seminar Series in
Biotechnology, RPI, June, 2007.
11. Studies on Glycobiology and Functional Glycomics, Zimmer Inc. Austin, July, 2006.
12. The Application of Wood Rotting Fungi in the Treatment of Colored Effluents Zhejiang
University of Technology, Hangzhou, China, July, 2005.
13. Decolorization of Azo Dyes with Wood Rotting Fungi, The University of Iowa, May, 2000.
F. ZHANG
20
14. The Treatment of Colored Effluents with Wood Rotting Fungi, National University of Singapore,
Dec.1998.
RESEARCH GRANTS AND CONTRACTS
Proposals Approved and Funded
1. U19FD004994-01 (Liu), 9/1/13-8/31/18, FAD. Probing the heparin structural elements for high
risk of heparin-induced thrombocytopenia (HIT). Role: Co-I.
2. R01HL125371 (Schmidt, Linhardt), 09/15/2014 – 05/31/2019, NIH. Endothelial glycocalyx
reconstitution during sepsis. Role: Co-I.
3. 1R01NS088496-01A1 (Yamaguchi), 07/01/2015–06/30/2020, NIH. Heparan sulfate in
neurophysiology and neurological disorders. Role: Co-I.
4. R21HL13627101 (Amster, Linhardt), 07/01/2016–06/30/2019, NIH. Rapid Sequencing of
Sulfated Glycans By CE-MS/MS. Role: Co-I.
5. 1R01DK111958-01A1 (McCarthy, Linhardt), 09/15/2017 – 06/30/2022, NIH. Role: Co-I.
Completed Grants
1. Co-PI, Development of a Bioengineered Heparin from a Non-Animal Source, NIH, for five years
(2009 to 2014).
2. Co-I, Industrial Sponsored Heparin Consortium Grant, 2011 to 2014
3. Co-I, Exosites in Activity and Inhibition of Matrix Metalloproteinases, National Institutes of
Health; Steven R. Van Doren (PI) University of Missouri, 7/1/11- 6/30/16.
4. Co-I, Synthetic Heparan Sulfate: probing Biosynthesis to Prepare Defined Drugs,
NIH R01, 12/01/12-11/30/17
5. Co-I, Uncovering the Controlling Mechanisms in Heparan Sulfate Biosynthesis, NIH R01
9/01/13-05/31/17.
6. Co-I, Conformational Quality in the Human Chemokine Ltn/XCL1, R01AI063325-01, Volkman
(PI), NIH, 2005 to 2010.
7. Co-PI, In Vitro Study on Extracorporeal Filtration System to Remove Oxaliplatin from Bovine
Blood, Delcath Systems, Inc. New York, 2008.
8. PI, Detection of OSCS in Heparinized Coating Material by Capillary Electrophoresis. Medtronic
Inc. Minnesota, 2008.
9. Co-PI, Heparin Pharmacokinetic Study Following Administration of Oral Heparin/SNAC, Oral
Liquid Heparin, Subcutaneous Heparin and Intravenous Heparin Injection to Healthy Male
Subjects, Emisphere Techologies, Inc. 2006
10. Co-PI, Metabolic Engineering of CHO Cells for high yield heparin production, NSF/NIH, 2009
to 2012.
11. Co-PI, An Artificial Golgi: Controlled GAG Synthesis and Screening, NIH (12/01/2009-
11/30/2013)
12. Co-PI, Characterization of Anticoagulant Heparin and Related Polysaccharides, NIH, GO Grant
with MIT (10/2009-09/2011).
13. Co-PI, In Vitro Study on Extracorporeal Filtration System to Remove Melphalan from Bovine
Blood, Delcath Systems, Inc. New York, 2009-2013.
14. Co-PI, Filtration Removal of Oxaliplatin from Blood, NIH (STTR) with Albany College of
Pharmacy, 2011 to 2012.
OTHER ACTIVITIES
F. ZHANG
21
Faculty searching for BCME Constellation, helping with the selection, scheduling and
interviewing the candidates.
Committee member of RPI Institute Biosafety Committee (IBC).
Daily Management of Linhardt Lab.
Directing the BIAcore Distributed Core Facility in the CBIS (maintenance of the SPR
instrument, training more than 20 new users and interactions with BIAcore company).
Intern Director for Imaging Core Facility in CBIS (2005).
Intern Director for Proteomics Core Facility in CBIS (2006).
Intern Director for Zebrafish Facility in CBIS (2009).
Undergraduate Student Advisor in Dept. of Chemical and Biological Engineering (Class 2014).
Recruiting Chinese graduate students and visiting Scholars.
Hosting prospective undergraduate/ graduate students for Dept. of Chemical and Biological
Engineering.
Reviewer for many scientific journals such as Nature Biotechnology, Journal of Biological
Chemistry, Biochemistry, Applied Microbiology and Biotechnology, Journal of American
Chemical Society, Journal of Chromatography, ChemBioChem, Enzyme and Microbial
Technology, Journal of Biochemistry and Biotechnology, Biotechnology and Bioengineering,
Analytical Biochemistry, Carbohydrate Polymer and Bioconjugate Journal, Journal of
Medicinal Chemistry.
Committee member for PhD defense in University of Binghamton.
Grant reviewer for NIH.
Grant reviewer for U.S. Civilian Research & Development Foundation (CRDF).