funding from wallace h. coulter foundation: bu-coulter translational partnership program
DESCRIPTION
Validating Patient Outcomes Using an iPad -Based Software Platform for Language & Cognitive Rehabilitation. Swathi Kiran , Carrie Des Roches , Isabel Balachandran , *Stephanie Keffer , Elsa Ascenso , *Anna Kasdan Speech and Hearing Sciences, Boston University - PowerPoint PPT PresentationTRANSCRIPT
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VALIDATING PATIENT OUTCOMES USING AN IPAD-BASED SOFTWARE
PLATFORM FOR LANGUAGE & COGNITIVE REHABILITATIONSwathi Kiran, Carrie Des Roches, Isabel Balachandran,
*Stephanie Keffer, Elsa Ascenso, *Anna KasdanSpeech and Hearing Sciences, Boston University
Department of Neurology, Massachusetts General Hospital
Funding from Wallace H. Coulter Foundation: BU-Coulter Translational Partnership Program
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Disclosure-Swathi KiranHas significant financial Interest• Chief Scientist for Constant Therapy• Ownership stock in Constant Therapy
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Other Authors: Carrie Des Roches, Isabel Balachandran, Elsa Ascenso- Nothing to discloseSignificant contributors- Stephanie Keffer, Anna Kasdan- Nothing to disclose
Disclosure
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Introduction• About 795,000 Americans each year suffer a new or
recurrent stroke (NIDCD.gov). Also, about 1.7 million individuals suffer from traumatic brain injury each year (CDC.gov).
• Individuals with language and cognitive deficits following brain damage likely require long-term rehabilitation.
• Consequently, it is a huge practical problem to provide the continued communication therapy that these individuals require.
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Using technology to improve treatment delivery
• Recent studies have examined the efficacy of rehabilitation techniques, such as videoconferencing, for individuals with hearing, stuttering and motor speech issues
• Other studies have provided aphasia therapy over the internet to individual patients
• More recently, there have several computerized brain-training software designed for normal adults.
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What is the evidence behind using technology to deliver treatment?
• CogMed• A software targeted at improving working memory abilities in
individuals with brain injury (Johansson & Tornmalm M, 2012; Lundqvist et al. 2012). These studies found improvements in working memory skills on the trained CogMed software as well as on other working memory tasks and functional settings.
• . Posit Science• Barnes et al (2009) examined the effectiveness of the software
Posit Science in improving auditory processing speed in individuals with mild cognitive impairment (MCI).
• Although differences between the experimental and control group were not statistically significant, verbal learning and memory measures were higher in the experimental group than the control group.
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What is the evidence behind using technology to deliver treatment? • Lumosity
• Finn and McDonald (2011) used Lumosity software to target attention, processing speed, visual memory in experimental and waitlisted controls. Results showed experimental participants improved on the training exercises more than the controls.
• There are other software programs- that function more like AAC- devices.
• Therefore, there an increased awareness and momentum for applying computer technology in the rehabilitation of aphasia
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Rationale• Additionally, there is increased patient demand to transition
from traditional but outdated flashcard based therapy in order to keep up with the evolution of technology.
• Nonetheless, the burden of evidence for technology-based treatment applications is no different than traditional treatment approach for rehabilitation after brain damage
• Q1. Can we provide a technologically based rehabilitation program that meets the same benchmarks for clinical efficacy?
• Q2. How do we individualize treatment for patients with brain damage as no two patients are alike?
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StudyQuestion: Does a structured therapy program that includes homework practice delivered through an IPAD result in significant gains in overall communication?
Goal: Compare patients who receive a structured IPAD delivered therapy program that is practiced up to 7 days a week with patients who receive standard one-on-one individualized therapy that is provided 1 or 2 days per week by a therapist.
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Study• Because of the flexibility that ipads provide to patients and
the accessibility to free/paid apps that provide variable levels of exercises, it is important to standardize the nature and form of treatment that is provided to patients using ipads.
• Since patients have access to ipads at home, it provides a unique opportunity to examine the extent of compliance when patients are provided with a homework regimen
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Participants Experiment (N = 40) Control (N= 9)
Ave Age 63 years (SD = 11) 68 years (SD = 10)Ave Months post Onset 54 months (SD = 47) 98 months (SD = 132)WAB – AQ (western aphasia battery)
68.5 (SD = 26.52) 68.1 (SD = 31.35)
CLQT Composite Severity (cognitive linguistic quick test)
64% (SD = 25) 54% (SD = 28)
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Demographic data
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Experimental Design
Pre-Tx Assessment
Pre-Tx Assessment
Post -TxAssessment
Weeks
Post -TxAssessment
EXPERIMENTAL PATIENTS (N = 40)
CONTROL PATIENTS (N = 10)
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Sample therapies/assessments for language and cognitive processing
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Structure of the tasks- Language
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Structure of the tasks- Cognitive
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Individualized therapy assignment based on initial performance
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Reading Passages (Level 3)
Picture Ordering Tasks (5 items)Map Tasks (10 items, Level 2)
Syllable Identification (10 items)Picture Spelling (Level 3)
Word IdentificationWord Copy (10 items)Category MatchingSound Identification (10 items)Clock Tasks (10 items)
Week1 Week2 Week3 Week4 Week5 Week6 Week 7 Week 8 Week 9 Week 10Picture Spelling (Level 2)
Addition (Level 3)
Addition (Level 4)
Addition (Level 4)
Addition (Level 4)
Addition (Level 5)
Syllable Identification
Syllable Identification
Syllable Identification
Multiplication (Level 4)
Reading Passage (Level 2)
Picture Spelling (Level 3)
Picture Spelling (Level 3)
Picture Spelling (Level 3)
Picture Spelling (Level 4)
Picture Spelling (Level 5)
Multiplication (Level 2)
Multiplication (Level 3)
Multiplication (Level 3)
Picture Ordering Tasks (Level 4, 10 items)
Word Ordering (Level 2)
Subtraction (Level 3, 5 items)
Subtraction (Level 3)
Subtraction (Level 3)
Subtraction (Level 4)
Subtraction (Level 5)
Picture Ordering Tasks
Picture Ordering Tasks (Level 2)
Picture Ordering Tasks (Level 3) Division (Level 3)
Reading Passage (Level 3)
Reading Passage (Level 3)
Reading Passage (Level 3)
Syllable Identification
Syllable Identification Division
Division (Level 2)
Clock Math (Level 2)
Word Ordering (Level 3)
Word Ordering (Level 3)
Word Ordering (Level 3)
Multiplication (10 items)
Multiplication (Level 2, 5 items)
Word Matching (10 items)
Map Tasks (Level 2)
Map Tasks (Level 3)
Map Tasks (Level 3)
Word Ordering Task (Level 4)
Word Ordering Task (Level 5)
# 29 during week 6 homework # 25 during week 4 homework
# 44 for all 10 weeks
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Based on WAB, CLQT
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Low Language profile- Low cognitive profile
High Language profile- low cognitive profile
Low language profile- high cognitive profile
High language profile- high cognitive profile
86 year old male 75 year old male 77 year old male 56 year old male
• category matching• feature matching• picture naming • rhyming• sound
identification• word identification• sound to letter
matching • word copy • picture matching• symbol
cancellation
• picture spelling• naming picture• clock reading • instruction
sequencing• picture ordering • sound matching• symbol matching• voicemail
• category identification
• category matching • feature matching• letter to sound
matching • reading passage• sound
identification• sound to letter
matching • word copy• word spelling• word ordering
• category matching• feature matching• letter to sound
matching • sound to letter
matching • map reading• picture spelling• reading passage• rhyming • Sound• identification• syllable
identification• word spelling• word problems
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Carrie/• Please insert snapshots of the patient dashboard- that
shows start therapy, we will now do…
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Methods• During the weekly clinic sessions, the clinician would
decide to continue the participant on the same task or to modify the treatment plan based on his/her performance.
• If the participant achieved 95% or higher accuracy two times in succession,• The clinician would either progress the next level of difficulty (e.g.,
Addition Level 1 to Addition Level 2) • Would progress to a different task (e.g., assign category
identification after category matching).• If participants performed at low accuracies or no change
over several sessions, that therapy task was replaced with another task from the task list.
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Overview of data analysis1. Total therapy duration in weeks2. Compliance- weekly log in times3. Individual patient level analysis
1. Analyze by week2. Analyze by task3. Analyze by item
4. Overall patient performance over time5. Patient performance over time relative to population mean6. Group level analysis: Analysis of tasks by patients7. Group level analysis: Analysis of task by items, co-factors8. Changes on standardized measures
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The average therapy period for controls was 12.964 weeks Average therapy period for experimental patients was 12.567 weeks
1 2 3 4 5 6 70
2
4
6
8
10
12
14
16
18
Weeks of iPad therapy: experimental vs. control
Controls (n=7)Experimental (n=36)
Patient
Ther
apy
Tim
e (w
eeks
)
1. Total therapy duration in weeks
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2. Compliance- Rates of log in to therapy
1/14/13
1/25/132/5/13
2/16/13
2/27/13
3/10/13
3/21/134/1/13
4/12/13
4/23/135/4/13
5/15/13
5/26/136/6/13
6/17/13
6/28/137/9/13
0
1
2
3
4
5
6
Control patients Experimental patients
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Patient usage by week
Legend:
Control patientsExperimental patients
Ideal
Contro
l90
469
888
2 52
Ideal
Experi
mental 81
395
583
1 25 29 47 527
913 24 68
3 28 81 335 59
1049 55
1 27 334 31 21
287
90
2
4
6
8
10
12
1.00
7.00
Average therapy time per week
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3. Individual patient level analysis: By week
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3. Individual patient level analysis: By task
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3. Individual patient level analysis: By items
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0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
Patient #44
Addition LV3 Addition LV4Addition LV5 Clock Math LV2Division LV1 Division LV2Division LV3 Division LV4Map Reading LV2 Map Reading LV3Multiplication LV1 Multiplication LV2Multiplication LV3 Multiplication LV4Multiplication LV5 Picture Ordering LV1Picture Ordering LV2 Picture Ordering LV3Picture Ordering LV4 Picture Ordering LV5Picture Spelling LV2 Picture Spelling LV3Picture Spelling LV4 Picture Spelling LV5Reading Passage LV2 Reading Passage LV3Subtraction LV3 Subtraction LV4Subtraction LV5 Syllable Identification LV1Voice Mail LV3 Word Matching LV1Word Ordering LV2 Word Ordering LV3Word Ordering LV4 Word Ordering LV5Word Problem LV2 Word Problem LV3
4. Historical individual performance
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Time
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
Patient #913
Addition LV4Clock Math LV2Clock Math LV3Division LV1Division LV2Long Reading Comprehension LV3Map Reading LV1Map Reading LV2Map Reading LV3Multiplication LV1Multiplication LV2Multiplication LV3Multiplication LV4Naming Picture LV1Picture Matching LV2Picture Matching LV3Picture Matching LV4Picture Ordering LV1Picture Ordering LV2Picture Ordering LV3Picture Ordering LV4Picture Ordering LV5Picture Spelling LV4Picture Spelling LV5Reading Passage LV3Rhyming LV1Subtraction LV2Subtraction LV3Subtraction LV4Word Problem LV1Word Problem LV2
4. Historical individual performance
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5. Patient performance over time relative to population mean
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6. Group level analysis: Analysis of tasks by patients- Individual Analysis Quantifying Change
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 210
0.2
0.4
0.6
0.8
1
1.2
0
2
4
6
8
10
12
14
f(x) = 0.00497816883116883 x + 0.778570619047619R² = 0.0466686384257462
f(x) = − 0.236876103896104 x + 8.66886380952381R² = 0.476925453249178
Rhyming
AccuracyLinear (Accuracy)LatencyLinear (Latency)
Individual analysis: Quantifying Change
• With tasks that had an R2 value of above 0.25, the average of the first two sessions was subtracted from the average of the last two sessions
• Then each of those values was determined to be a “good” or a “bad” change• A “good” change in accuracy was any value above 0• A “good” change in latency was any value below 0
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Individual subject analysis by task Low Language profile- Low cognitive profile
High Language profile- low cognitive profile
Low language profile- high cognitive profileHigh language profile- high cognitive profile
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Group analysis of task improvementAverage % Significant (Overall) 19.63%% of 19.63% considered to be "Good" 79.62%
Act
ive
Sen
tenc
e C
ompl
etio
n LV
1A
dditi
on L
V2
Add
ition
LV
5C
lock
Mat
h LV
1C
lock
Rea
ding
LV
1D
ivis
ion
LV2
Div
isio
n LV
5Fe
atur
e M
atch
ing
LV3
Lette
r to
Sou
nd M
atch
ing
LV1
Long
Rea
ding
Com
preh
ensi
on L
V2
Map
Rea
ding
LV
2M
ultip
licat
ion
LV2
Mul
tiplic
atio
n LV
5N
amin
g P
ictu
re L
V3
Pic
ture
Mat
chin
g LV
1P
ictu
re M
atch
ing
LV4
Pic
ture
Ord
erin
g LV
2P
ictu
re O
rder
ing
LV5
Pic
ture
Spe
lling
Com
plet
ion
LV3
Pic
ture
Spe
lling
LV
2P
ictu
re S
pelli
ng L
V5
Rea
ding
Pas
sage
LV
3S
ound
Mat
chin
g LV
1S
ound
Mat
chin
g LV
4S
ubtra
ctio
n LV
1S
ubtra
ctio
n LV
4S
ymbo
l Mat
chin
g LV
1S
ymbo
l Mat
chin
g LV
3S
ymbo
l Mat
chin
g LV
6S
ymbo
l Mat
chin
g LV
9V
oice
mai
l LV
3W
ord
Cop
y C
ompl
etio
n LV
3W
ord
Cop
y LV
1W
ord
Cop
y LV
4W
ord
Mat
chin
g LV
1W
ord
Ord
erin
g LV
1W
ord
Ord
erin
g LV
4W
ord
Pro
blem
LV
2W
ord
Pro
blem
LV
5W
ord
Spe
lling
Com
plet
ion
LV3
Wor
d S
pelli
ng L
V1
Wor
d S
pelli
ng L
V4
0.00%10.00%20.00%30.00%40.00%50.00%60.00%70.00%80.00%90.00%
100.00%
Percent of patients with significant R2 values by task for accuracy and latency
Percent of Significant R2 Percent of Significant considered "Good"
Activ
e Se
nten
ce C
ompl
etio
n LV
1Ad
ditio
n LV
2Ad
ditio
n LV
5Cl
ock
Mat
h LV
1Cl
ock
Rea
ding
LV
1Di
visi
on L
V2Di
visi
on L
V5
Feat
ure
Mat
chin
g LV
3
Lette
r to
Soun
d M
atch
ing
LV1
Long
Rea
ding
Com
preh
ensi
on L
V2M
ap R
eadi
ng L
V2M
ultip
licat
ion
LV2
Mul
tiplic
atio
n LV
5Na
min
g Pi
ctur
e LV
3Pi
ctur
e M
atch
ing
LV1
Pict
ure
Mat
chin
g LV
4Pi
ctur
e O
rder
ing
LV2
Pict
ure
Ord
erin
g LV
5
Pict
ure
Spel
ling
Com
plet
ion
LV3
Pict
ure
Spel
ling
LV2
Pict
ure
Spel
ling
LV5
Read
ing
Pas
sage
LV3
Soun
d M
atch
ing
LV1
Soun
d M
atch
ing
LV4
Subt
ract
ion
LV1
Subt
ract
ion
LV4
Sym
bol M
atch
ing
LV1
Sym
bol M
atch
ing
LV3
Sym
bol M
atch
ing
LV6
Sym
bol M
atch
ing
LV9
Voic
emai
l LV3
Wor
d C
opy
Com
plet
ion
LV3
Wor
d Co
py L
V1W
ord
Copy
LV4
Wor
d M
atch
ing
LV1
Wor
d O
rder
ing
LV1
Wor
d O
rder
ing
LV4
Wor
d Pr
oble
m L
V2W
ord
Pro
blem
LV5
Wor
d Sp
ellin
g Co
mpl
etio
n LV
3W
ord
Spe
lling
LV1
Wor
d Sp
ellin
g LV
4
0.00%10.00%20.00%30.00%40.00%50.00%60.00%70.00%80.00%90.00%
100.00%
ACCURACY
Percent of Significant R2 Percent of Significant considered "Good"
Perc
ent o
f sig
nific
ant R
2 va
lue
Change in GOOD Significant R2 Accuracy (%)Average 14.45%Smallest Change 0.48%Largest Change 74.86%
Group analysis of task improvement
Activ
e Se
nten
ce C
ompl
etio
n LV
1Ad
ditio
n LV
2Ad
ditio
n LV
5Cl
ock
Mat
h LV
1Cl
ock
Rea
ding
LV
1Di
visi
on L
V2Di
visi
on L
V5
Feat
ure
Mat
chin
g LV
3
Lette
r to
Soun
d M
atch
ing
LV1
Long
Rea
ding
Com
preh
ensi
on L
V2M
ap R
eadi
ng L
V2M
ultip
licat
ion
LV2
Mul
tiplic
atio
n LV
5Na
min
g Pi
ctur
e LV
3Pi
ctur
e M
atch
ing
LV1
Pict
ure
Mat
chin
g LV
4Pi
ctur
e O
rder
ing
LV2
Pict
ure
Ord
erin
g LV
5
Pict
ure
Spel
ling
Com
plet
ion
LV3
Pict
ure
Spel
ling
LV2
Pict
ure
Spel
ling
LV5
Read
ing
Pas
sage
LV3
Soun
d M
atch
ing
LV1
Soun
d M
atch
ing
LV4
Subt
ract
ion
LV1
Subt
ract
ion
LV4
Sym
bol M
atch
ing
LV1
Sym
bol M
atch
ing
LV3
Sym
bol M
atch
ing
LV6
Sym
bol M
atch
ing
LV9
Voic
emai
l LV3
Wor
d Co
py C
ompl
etio
n LV
3W
ord
Copy
LV1
Wor
d Co
py L
V4W
ord
Mat
chin
g LV
1W
ord
Ord
erin
g LV
1W
ord
Ord
erin
g LV
4W
ord
Prob
lem
LV2
Wor
d Pr
oble
m L
V5
Wor
d Sp
ellin
g Co
mpl
etio
n LV
3W
ord
Spel
ling
LV1
Wor
d Sp
ellin
g LV
4
0.00%10.00%20.00%30.00%40.00%50.00%60.00%70.00%80.00%90.00%
100.00%
LATENCY
Percent of Significant R2 Percent of Significant considered "Good"
Perc
ent o
f sig
nific
ant R
2 va
lues
Change in GOOD Significant R2 Latency (seconds)Average 0.144538506Largest Change 0.74861Smallest Change 0.004765
Group analysis of task improvement
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7. Group level analysis- co-factors• Mixed regression models
for each treatment task• For e.g., for word
identification
Overall effect of treatment is significant
Estimates for Accuracy Label Estimate SE DF t value Pr > |t|Conditional improvement 0.01961 0.0091 294 2.15 0.0325
Effect of WABAQ on improvement
-0.00066 0.0001 294 -4.88 <.0001
Effect of Composite Severity on improvement
0.01820 0.0137 294 1.32 0.1874
Task Accuracy LatencyEstimate p value Estimate P value
Category Identification -0.00633 0.5397 0.1135 0.569Category Matching -0.00019 0.9641 -0.05835 0.2064Feature Matching 0.02356 0.0034 -0.1878 0.0109Letter to sound matching Level 2 0.01018 0.294 -0.5329 0.0002Rhyming 0.01521 0.0032 -0.0223 0.6982Word spelling completion LV 1 0.01456 0.0187 -0.09176 0.3882Word Identification 0.01961 0.0325 0.1173 0.0183Addition Level 1 0.122 0.3455 -5.9979 0.0847Addition LV2 -0.05748 0.0307 2.8665 0.0093Addition LV3 -0.1141 0.1456 1.6905 0.1655Addition LV4 -0.1361 0.1438 -3.1877 0.0719Addition LV5 0.02881 0.1826 0.1198 0.8927Clock Reading Level 1 0.000816 0.9405 -0.4324 0.0016Clock Math Lv 2 -0.03675 0.9272 33.3335 0.0458Clock Math LV3 0.01032 0.9718Division LV1 0.05175 0.6368 -0.7804 0.7296Division LV4 0.48 0.9587 618.69 0.3172Instruction sequencing 0.03433 0.6964 4.6205 0.0971Map Reading LV1 0.2592 0.0014 0.09436 0.9073Map Reading LV2 -0.1268 0.1432 16.2842<.0001
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7. Can treatment outcome be predicted for each patient?
Solution for Random Effects
PatientId Estimate Std Err Pred DF t Value Pr > |t|23 -0.07216 0.2081 589 -0.35 0.728924 -0.5612 0.1757 589 -3.19 0.0015 903 0.4057 0.2544 589 1.59 0.1113913 0.3272 0.3258 589 1.00 0.3157955 0.08395 0.2471 589 0.34 0.7342978 1.0518 0.2442 589 4.31 <.00011049 -0.9511 0.1953 589 -4.87 <.00011079 -0.02336 0.2463 589 -0.09 0.92451091 -0.3460 0.2881 589 -1.20 0.23031339 0.4617 0.2044 589 2.26 0.0243
This patient show significantly less
improvement than the average improvement
This patient show significantly more improvement than
the average improvement
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8. Mean Changes on standardized test performance
LQ CQ AQ
Attenti
on
Memory
Execu
tive F
uncti
ons
Lang
uage
Visuos
patia
l Skil
ls
Compo
site S
everi
ty
Clock D
rawing BNT
-4
-2
0
2
4
6
8
10
12
14
Changes in standardized testing scores: experiemtnal vs. control
Average Control Change (n=9)Average TX Change (n=40)
Aver
age
Chan
ge in
Sco
re (P
ost-P
re)
WAB CLQT BNT
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8. Change on standardized testsSubtest Experimental Group
(N= 40)Control Group (N = 9)
WAB-LQ 2.13% (t = -2.05, p <.05) 1.42% (t = 1.07, ns)
WAB-CQ 2.60% (t = -2.05, p <.05) 1.32% (t = 1.03, ns)
WAB-AQ 4.14% ( t = 3.11, p <.01) 0.65% (t = .76, ns)
CLQT-composite severity 9.12% (t = 3.28, p < .01) 4.44 % (t = .76, ns)
CLQT-Attention 11.3 % (t = -.4.55, p <.0001)
7.6% (t = -1.19, ns)
CLQT-Memory 1.55% (t = -0.84, ns) 1.140 (t = 0.30, ns)
CLQT-Executive Function 6.41% (t = 3.15, p < .01) 1.66 (t = 0.52, ns)
CLQT- Language 1.42% (t = 1.15, ns) 1.65 (t = 1.26, ns)
CLQT- Visuospatial skills 7.81 (t = 3.43, p < .001) 2.96 (t = 0.61, ns)
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Summary of results• Experimental and control patients completed 11 weeks of
treatment• Patient compliance was high-ranged from 1 time/week to 11
times/week• Patients who logged in more often showed more changes on
tasks assigned• Individual patient analysis by items, task, weekly- gives
insight into how patients perform• Changes in accuracy and latency are across tasks • Changes seen on standardized tests for experimental
patients, less for control patients
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THANK YOU ! Questions?
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References• Barnes D, Yaffe K, Belfor N, Jagust W, DeCarli C, Reed B, Kramer J.
Computer-Based Cognitive Training for Mild Cognitive Impairment: Results from a Pilot Randomized, Controlled Trial. Alzheimer Disease and Associated Disorders 2009; 23(3), 205-210.
• Finn M, McDonald S. Computerised cognitive training for older persons with mild cognitive impairment: A pilot study using a randomised controlled trial design. Brain Impairment 2011; 12(3), 187–199.
• Johansson B, Tornmalm M. Working memory training for patients with acquired brain injury: Effects in daily life. Scandanavian Journal of Occupational Therapy 2012; 19(2), 176-83. doi:10.3109/11038128.2011.603352.
• Lundqvist A, Grundström K, Samuelsson K, Rönnberg J Computerized training of working memory in a group of patients suffering from acquired brain injury. Brain Injury 2010; 24, 1173-1183. doi:10.3109/02699052.2010.498007